 |
- Condition: Healthy Volunteers
Interventions: Drug: AZD4635 50 mg nano-suspension (reference); Drug: AZD4635 solid oral formulation - fasted; Drug: AZD4635 solid oral formulation - fed; Drug: Lansoprazole and AZD4635 50 mg solid oral formulation; Drug: AZD4635 solid oral formulation variant 1 - fasted; Drug: AZD4635 solid oral formulation variant 2 - fasted; Drug: [14C] AZD4635 IV microtracer - fasted
Sponsors: AstraZeneca; Quotient Sciences
Not yet recruiting - Condition: Cerebrovascular Circulation
Interventions: Drug: Darolutamide (BAY1841788); Drug: Enzalutamide; Other: Placebo
Sponsor: Bayer
Not yet recruiting - Condition: Cardiac Sarcoidosis
Interventions: Other: 18F-FDG; Drug: Prednisolone
Sponsor: University of Edinburgh
Recruiting - Conditions: Cardiovascular Disease+Pulmonary Disease; Pulmonary Arterial Hypertension
Interventions: Drug: BIA 5-1058; Drug: Placebo
Sponsor: Bial - Portela C S.A.
Recruiting - Condition: Endometriosis
Interventions: Drug: Placebo; Drug: FOR-6219
Sponsors: Forendo Pharma Ltd; Richmond Pharmacology Limited
Recruiting - Condition: Healthy
Interventions: Dietary Supplement: Beta-alanine; Dietary Supplement: Placebo
Sponsor: University of Exeter
Recruiting - Condition: Malaria
Intervention: Biological: ChAd63 ME-TRAP and MVA ME-TRAP vaccination
Sponsor: University of Oxford
Not yet recruiting - Condition: Obesity
Interventions: Dietary Supplement: Natural high potency sweetener from leaf extract; Dietary Supplement: Glucose; Dietary Supplement: Sucrose; Dietary Supplement: Maltodextrin; Dietary Supplement: Water
Sponsors: University of Manchester; Cargill
Active, not recruiting - Conditions: Cognitive Change; Mood Change
Interventions: Dietary Supplement: Cognivia; Dietary Supplement: Placebo
Sponsor: Northumbria University
Recruiting - Conditions: Healthy; Atopic Dermatitis
Interventions: Drug: MOR106; Drug: Placebo
Sponsor: Galapagos NV
Recruiting - Condition: Hepatitis C
Interventions: Biological: ChAd3-hliNSmut; Biological: MVA-hliNSmut
Sponsors: University of Oxford; Oxford University Hospitals NHS Trust; ReiThera Srl; European Commission; GlaxoSmithKline
Recruiting - Conditions: Deglutition; Physiology
Intervention: Device: rTMS
Sponsor: University of Manchester
Not yet recruiting - Condition: High Intensity Interval Training
Interventions: Other: High intensity interval training; Other: Moderate intensity continuous training
Sponsors: University of Central Lancashire; University of Hull
Completed - Conditions: Frailty; Sarcopenia; Aging
Interventions: Behavioral: Consultation; Behavioral: Online Support; Behavioral: Empowered
Sponsors: Aberystwyth University; EIT Health
Active, not recruiting - Conditions: Risk Factor, Cardiovascular; Physical Activity; Pre-diabetes
Intervention: Behavioral: Exercise
Sponsor: Kingston University
Recruiting - Condition: Healthy Subjects
Intervention: Drug: Cefepime 2 gram
Sponsor: Allecra
Recruiting - The Effect of Pain Education on Multidisciplinary Healthcare Students' Understanding of Chronic PainCondition: Knowledge, Attitudes, Practice
Interventions: Other: Pain neuroscience education; Other: Red flag education
Sponsor: Teesside University
Recruiting - Condition: Muscle Damage
Interventions: Device: Compression garments; Other: Sham recovery drink
Sponsors: St Mary's University College; Modern Pentathlon GB
Recruiting - Condition: Muscle Damage
Interventions: Device: Custom fitted compression garments (CF); Device: Standard-sized compression garments (SSG); Procedure: Sham ultrasound (CON)
Sponsor: St Mary's University College
Completed - Conditions: Emotional Processing; Mental Exercise
Interventions: Behavioral: Three good things exercise; Behavioral: Placebo exercise
Sponsor: University of Oxford
Recruiting - Conditions: Aging; Cognitive Decline
Interventions: Dietary Supplement: Freeze-Dried Cranberry Powder; Dietary Supplement: Placebo
Sponsors: University of East Anglia; Clinical Research and Trials Unit (Norfolk & Norwich University Hospital, UK)
Recruiting - Conditions: Pramipexole; Emotions; Motivation; Reward; Dopamine
Interventions: Drug: Pramipexole; Drug: Placebo
Sponsor: University of Oxford
Recruiting - Condition: Healthy
Interventions: Drug: Lu AF35700; Drug: Lu AF35700 iv
Sponsor: H. Lundbeck A/S
Recruiting - Condition: RSV Infection
Interventions: Drug: EDP-938 Dose 1; Drug: EDP-938 Dose 2; Drug: Placebo
Sponsors: Enanta Pharmaceuticals; hVIVO Services Limited
Recruiting - Condition: Cognitive Change
Interventions: Dietary Supplement: Zanthozylum armatum; Dietary Supplement: Placebo
Sponsors: Northumbria University; Mibelle AG
Active, not recruiting - Condition: Healthy Volunteers
Interventions: Drug: Cortexolone 17α-propionate solution; Drug: Placebo
Sponsor: Cassiopea SpA
Recruiting - Condition: Pre Diabetes
Interventions: Other: DNA-based dietary intervention; Other: DNA-based dietary intervention using an app; Other: Control arm
Sponsors: Imperial College London; DnaNudge Ltd
Recruiting - Conditions: Bright Light Treatment; Emotion; Facial Expression Recognition
Interventions: Device: Bright light treatment lamp; Device: Sham negative ion generator
Sponsors: University of Oxford; Medical Research Council; P1vital Products Limited
Completed - Conditions: Kidney Transplant; Complications; Obesity; Physical Activity; Weight Gain; Health Behavior
Intervention: Other: ExeRTiOn
Sponsors: King's College Hospital NHS Trust; Kidney Cancer UK
Recruiting - Condition: Optokinetic Nystagmus
Intervention: Device: CAVA
Sponsors: Emily Woodhouse; University of East Anglia; Medical Research Council
Recruiting - Condition: Hepatitis C
Intervention: Behavioral: Respondent Driven Sampling
Sponsors: NHS Tayside; University of Dundee
Enrolling by invitation - Condition: Aerobic Capacity
Interventions: Dietary Supplement: 500mg of Aronox® >40% polyphenol aronia extract; Other: Placebo
Sponsors: Northumbria University; Naturex
Recruiting - Condition: Auditory Processing Disorder
Intervention: Device: Bone-conduction headset
Sponsor: Children's Hearing Evaluation and Amplification Resource, Ltd.
Not yet recruiting - Condition: Muscle Damage
Interventions: Dietary Supplement: 500mg of Aronox® >40% polyphenol aronia extract; Other: Placebo
Sponsors: Northumbria University; Naturex SA
Recruiting - Condition: Crohn Disease
Interventions: Diagnostic Test: Muscle strength and fatigue assessment; Diagnostic Test: Dual-energy X-ray absorptiometry (DEXA scan); Diagnostic Test: Supine cardiorespiratory fitness assessment; Diagnostic Test: fMRI Exercise assessment; Diagnostic Test: Muscle deconditioning assessment
Sponsor: University of Nottingham
Recruiting - Conditions: Respiratory Syncytial Virus Infections; RSV Infection
Interventions: Procedure: venepuncture; Procedure: nasopharyngeal swab
Sponsor: University of Oxford
Recruiting - Conditions: Aggression; Anger
Intervention: Behavioral: Volitional Help Sheet (VHS)
Sponsors: University of Sheffield; University of Manchester
Enrolling by invitation - Condition: Healthy
Intervention: Drug: 200 mg Ibuprofen acid orodispersible tablet
Sponsors: Reckitt Benckiser Healthcare (UK) Limited; Simbec Research
Terminated - Condition: Pertussis
Intervention: Biological: Boostrix®-IPV combination vaccine
Sponsors: University of Oxford; National Institute for Public Health and the Environment (RIVM); University of Turku
Recruiting - Condition: Subacromial Impingement Syndrome
Intervention: Procedure: Subacromial Injection
Sponsor: Aneurin Bevan University Health Board
Recruiting - Conditions: Asthma; COPD; Heart Failure; Community-acquired Pneumonia; Healthy; Breathlessness
Intervention:
Sponsors: University of Leicester; Medical Research Council; Engineering and Physical Sciences Research Council, UK; Loughborough University; University Hospitals, Leicester; Owlstone Ltd; B & S ANALYTIK GmbH; Advion Biosciences Ltd
Recruiting - Condition: Healthy Aging
Interventions: Other: Grammatical Reasoning; Other: Card Pairs
Sponsors: University of Exeter; South London and Maudsley NHS Foundation Trust; King's College London; Wesnes Cognition Ltd
Active, not recruiting - Conditions: Safety; Immunogenicity
Interventions: Biological: ChAdOx185A; Biological: MVA85A; Biological: BCG
Sponsors: University of Oxford; MRC/UVRI and LSHTM Uganda Research Unit
Not yet recruiting - Conditions: Heart Failure; Diffuse Fibrosis; Focal Fibrosis; Arrythmia
Intervention:
Sponsor: University Hospital Southampton NHS Foundation Trust
Recruiting - Condition: Closed Fracture of Shaft of Humerus
Interventions: Procedure: Operative; Device: Humeral brace
Sponsors: Royal Infirmary of Edinburgh; NHS Lothian; University of Edinburgh
Recruiting - Conditions: Cognitive Change; Stress, Psychological; Mood
Interventions: Dietary Supplement: Avena sativa; Dietary Supplement: Placebo
Sponsors: Northumbria University; Anklam Extrakt
Recruiting - Condition: Dementia
Interventions: Other: Foods consistent with a MDP; Other: Physical Activity; Other: Control
Sponsor: University of East Anglia
Not yet recruiting - Condition: Exercise Performance
Interventions: Other: Active Nitrate Bar; Other: Placebo Bar
Sponsor: PepsiCo Global R&D
Completed - Condition: Healthy
Interventions: Dietary Supplement: Low nucleotide; Dietary Supplement: High nucleotide; Dietary Supplement: High nucletide + Ribose
Sponsor: University of Exeter
Recruiting - Condition: Staff Attitude
Intervention: Other: No Intervention
Sponsors: Bournemouth University; Royal Bournemouth Hospital
Recruiting - Condition: Healthy Subjects
Interventions: Drug: IONIS-ENaCRx; Drug: Placebo
Sponsor: Ionis Pharmaceuticals, Inc.
Not yet recruiting - Condition: Oocyte Competence
Intervention: Other: Image acquisition and analysis
Sponsors: Center for Reproductive an Genetic Health; University College, London
Not yet recruiting - Condition: Eccentric Hip Adduction Strength
Intervention: Other: Copenhagen adductor exercise
Sponsors: University of Bath; Copenhagen University Hospital, Hvidovre
Active, not recruiting - Condition: Asthma
Interventions: Drug: TD-8236 (for SAD); Drug: TD-8236 (for MAD); Drug: Placebo (for SAD); Drug: Placebo (for MAD)
Sponsor: Theravance Biopharma
Not yet recruiting - Condition: Autism Spectrum Disorder
Interventions: Drug: AZD7325_10; Drug: AZD7325_20; Drug: Placebo
Sponsor: King's College London
Recruiting - Condition: Physical Activity
Intervention: Behavioral: Mindfulness for Physical Activity
Sponsor: Liverpool John Moores University
Active, not recruiting - Condition: Diabetes Mellitus, Type 2
Intervention: Behavioral: Best Possible Self
Sponsor: Liverpool John Moores University
Recruiting - Condition: Autoimmune Diseases
Interventions: Drug: GSK2982772 MR1 formulation; Drug: GSK2982772 MR2 formulation; Drug: GSK2982772 IR formulation; Drug: GSK2982772 MR3 formulation; Drug: GSK2982772 MR4 formulation; Drug: GSK2982772 MRX-1; Drug: GSK2982772 MRX-2
Sponsors: GlaxoSmithKline; Quotient Sciences
Recruiting - Condition: Mood Disorders
Interventions: Dietary Supplement: Proprietary, standardized botanical extract; Dietary Supplement: Placebo (maltodextrin)
Sponsors: Activ'inside; Northumbria University
Recruiting - Conditions: Diabetes Mellitus; Obesity
Interventions: Drug: Y14; Drug: Placebo
Sponsors: Imperial College London; Medical Research Council; Covance
Recruiting - Condition: Healthy
Intervention: Drug: BDM-2 in Bottle (50 mg - 3600 mg); oral suspension
Sponsors: Hivih; Venn Life Sciences
Completed - Condition: Bioequivalence
Interventions: Drug: Imeglimin Reference product; Drug: Imeglimin
Sponsor: Poxel SA
Not yet recruiting - Conditions: Blood Biomarkers; Vasodilation; Blood Clotting; Lung Function; Healthy Volunteers
Interventions: Other: diesel exhaust particulate; Other: carbon nanoparticles; Other: small graphene oxide; Other: ultrasmall graphene oxide; Other: filtered air
Sponsors: University of Edinburgh; NHS Lothian
Recruiting - Conditions: Dementia; Alzheimer Disease; Mild Cognitive Impairment; Aging; Cognitive Impairment
Intervention: Behavioral: Cognitive Training
Sponsors: University of Leicester; The Dunhill Medical Trust; University Hospitals, Leicester; Leicestershire Partnership Trust; University of Nottingham; Lumosity
Not yet recruiting - Conditions: Osteoarthritis, Knee; Pain, Joint
Interventions: Behavioral: Exercise; Other: analgesic optimisation
Sponsor: University of Nottingham
Not yet recruiting - Condition: Healthy Volunteers
Interventions: Drug: Tolcapone; Drug: Tolcapone Modified Release Prototype; Drug: Tolcapone Divided Dose
Sponsors: Corino Therapeutics, Inc.; Quotient Sciences
Active, not recruiting - Condition: Family Caregivers
Intervention:
Sponsor: University of Manchester
Recruiting - Conditions: Leg Length Discrepancy; Leg Length Difference
Intervention: Device: LIV 30 Hz
Sponsor: University College, London
Recruiting - Conditions: Optic Neuritis; Optic; Neuritis, With Demyelination
Intervention: Drug: Comparison of BN201 treatment with Placebo
Sponsors: Bionure Farma SL; Simbec Research
Recruiting - Conditions: Obesity; Taste Sensitivity
Intervention: Other: No Intervention
Sponsor: St Mary's University College
Recruiting - Condition: Bipolar Depression
Intervention: Other: Behavioural Activation (BA)
Sponsors: University of Exeter; Devon Partnership NHS Trust
Recruiting - Condition: Infections, Upper Respiratory Tract
Interventions: Dietary Supplement: Probiotic strain; Dietary Supplement: Placebo
Sponsors: Chr Hansen; Onorach Clinical; CPS Research
Not yet recruiting - Conditions: Stillbirth; Fetal Death; Fetal Growth Retardation; Small for Gestational Age; Fetal Growth Restriction; Perinatal Death; Intrauterine Growth Restriction
Intervention:
Sponsor: Oxford University Hospitals NHS Trust
Recruiting - Condition: Frail Elderly Syndrome
Intervention: Other: resistance training
Sponsors: University of Glasgow; NHS Greater Glasgow and Clyde
Recruiting - Condition: Chronic Low Back Pain
Intervention: Behavioral: Psychodynamic Interpersonal Therapy (PIT)
Sponsor: Charlotte Morgan
Active, not recruiting - Condition: Topical Anaesthesia
Interventions: Device: Microneedle Patch; Device: Patch with no microneedles
Sponsor: Innoture Ltd
Completed - Condition: Healthy
Interventions: Drug: Imeglimin; Drug: Cimetidine
Sponsor: Poxel SA
Completed - Condition: Parkinson Disease Psychosis
Interventions: Drug: Saracatinib; Drug: Placebo Oral Tablet
Sponsors: King's College London; AstraZeneca; King's College Hospital NHS Trust
Not yet recruiting - Condition: Airway Obstruction
Intervention: Other: Airway Assessment
Sponsor: University Hospitals Coventry and Warwickshire NHS Trust
Recruiting - Condition: Healthy
Intervention: Dietary Supplement: Molkosan
Sponsors: University of Aberdeen; A. Vogel
Completed - Condition: Ocular Surface Disease
Intervention: Other: Autologous blood applied to dry eye
Sponsors: NHS Lanarkshire; Chief Scientist Office of the Scottish Government; NHS Research Scotland
Recruiting - Safety, Tolerability and Long-term Immunogenicity of Different Formulations of a Chikungunya VaccineCondition: Chikungunya Virus Infection
Interventions: Biological: MV-CHIK lyophilised formulation, low dose; Biological: MV-CHIK liquid frozen formulation, low dose; Biological: MV-CHIK SPS® formulation, low dose; Biological: MV-CHIK liquid frozen formulation, high dose; Biological: MV-CHIK liquid frozen formulation, high dose and placebo
Sponsor: Themis Bioscience GmbH
Not yet recruiting - Condition: Prostate Cancer
Intervention: Device: MR LINAC
Sponsor: Royal Marsden NHS Foundation Trust
Recruiting - Condition: Ischemia, Myocardial
Intervention: Diagnostic Test: Deformation imaging
Sponsors: University Hospital of Wales; Leuven University; Universitat Pompeu Fabra; Hull and East Yorkshire Hospitals NHS Trust; Danderyd Hospital
Recruiting - Condition: Cardiac Amyloidosis
Intervention: Other: 18F-NaF PET
Sponsor: University of Edinburgh
Recruiting - Condition: Ultrasound Imaging of Anatomical Structures
Intervention:
Sponsor: Medaphor Limited
Recruiting - Condition: Healthy Japanese Volunteers
Interventions: Drug: UCB0107; Other: Placebo
Sponsor: UCB Biopharma S.P.R.L.
Recruiting - Conditions: Overweight and Obesity; Diet Modification; Body Weight
Interventions: Other: isomaltulose (Palatinose(TM); Other: Sucrose
Sponsor: Beneo-Institute
Completed - Condition: Bipolar Disorder
Interventions: Drug: JNJ-18038683; Drug: Placebo
Sponsor: King's College London
Recruiting - Condition: Healthy Subjects
Intervention: Drug: Uproleselan
Sponsors: GlycoMimetics Incorporated; Quotient Sciences
Not yet recruiting - Conditions: Acute Aortic Syndrome; Aortic Dissection; Penetrating Aortic Ulcer; Intramural Hematoma
Interventions: Diagnostic Test: 18F Sodium Fluoride Positron Emission Tomography / Computed Tomography; Diagnostic Test: CT Aortic Angiogram; Diagnostic Test: Aortic MRI
Sponsors: University of Edinburgh; NHS Lothian; British Heart Foundation
Not yet recruiting - Condition: Obesity
Interventions: Drug: Intranasal Insulin; Drug: Intranasal Placebo
Sponsors: University of Birmingham; Queen Elizabeth Hospital NHS Foundation Trust
Recruiting - Conditions: Healthy; Overweight and Obesity
Interventions: Dietary Supplement: Blood orange juice; Dietary Supplement: Control drink
Sponsor: University of Leeds
Active, not recruiting - Condition: Adrenal Insufficiency
Intervention:
Sponsors: Imperial College London; National Institute for Health Research, United Kingdom
Recruiting - Condition: Cystic Fibrosis
Interventions: Other: Oral Glucose Tolerance Test (OGTT) assessment arm; Other: Mixed meal test evaluation test arm
Sponsor: Liverpool Heart and Chest Hospital NHS Foundation Trust
Withdrawn - Conditions: Ischemic Cardiomyopathy; Dilated Cardiomyopathy; Hypertrophic Cardiomyopathy
Intervention: Other: Mangafodipir trisodium
Sponsor: University of Edinburgh
Recruiting - Condition: Acceptance, Social
Intervention: Dietary Supplement: Biscuit acceptance
Sponsors: Newcastle University; University of Aberdeen; University of Bristol; University of Liverpool
Not yet recruiting - Condition: Healthy
Interventions: Dietary Supplement: Wild Blueberry Powder; Dietary Supplement: Placebo
Sponsors: King's College London; University of Reading
Recruiting - Condition: Influenza Vaccination
Intervention: Other: Communication intervention
Sponsors: University of Warwick; University Hospital Birmingham
Recruiting - Condition: Cognitive Change
Interventions: Dietary Supplement: Lactobacillus paracasei Lpc-37; Dietary Supplement: Placebo
Sponsors: Northumbria University; DuPont Nutrition and Health
Recruiting - Condition: Diet Modification
Interventions: Behavioral: Mindful eating; Behavioral: Eating without distractions
Sponsor: City, University of London
Recruiting - Condition: Obesity
Intervention: Device: VeSTAL
Sponsors: Neurovalens Ltd.; University of California, San Diego; University of Ulster; Exploristics
Not yet recruiting - Condition: Corneal Astigmatism
Interventions: Device: Toric intraocular MX60T lens; Other: Standard MX60 plus corneal incisions
Sponsors: Ashford and St. Peter's Hospitals NHS Trust; Bausch & Lomb Incorporated
Recruiting - Condition: Meningococcal Infection
Interventions: Biological: Meningococcal polysaccharide (serogroups A,C,Y and W) tetanus toxoid conjugate vaccine MenACYW conjugate vaccine; Biological: Meningococcal group B vaccine; Biological: Diphtheria, tetanus, pertussis (acellular component), hepatitis B, poliomyelitis (inactivated) vaccine; Biological: Human rotavirus RIX4414 strain vaccine; Biological: Pneumococcal 13-valent polysaccharide conjugate vaccine
Sponsor: Sanofi Pasteur, a Sanofi Company
Recruiting - Conditions: Dementia Alzheimers; Dementia; Dementia, Vascular; Dementia Senile
Intervention:
Sponsor: Moorfields Eye Hospital NHS Foundation Trust
Not yet recruiting - Condition: Chikungunya Fever
Intervention: Biological: ChAdOx1 Chik
Sponsor: University of Oxford
Recruiting - Conditions: Healthy; Frontotemporal Dementia
Interventions: Biological: AL001; Other: Placebo
Sponsor: Alector Inc.
Recruiting - Conditions: Retinal Disease; Retinal Degeneration; Retinal Dystrophies
Intervention: Device: Long-wavelength autofluorescence imaging
Sponsor: Oxford University Hospitals NHS Trust
Not yet recruiting - Condition: Memory Consolidation
Interventions: Dietary Supplement: Olive Oil Placebo; Dietary Supplement: EPA-rich; Dietary Supplement: DHA-rich
Sponsors: Northumbria University; BASF
Active, not recruiting - Condition: Cardiovascular Diseases
Intervention: Device: High-Flow Humidified Nasal Oxygen
Sponsor: Torbay and South Devon NHS Foundation Trust
Recruiting - Condition: Exercise Performance
Interventions: Other: Test Beet Shot; Other: Placebo Beverage
Sponsor: PepsiCo Global R&D
Completed - Condition: Postoperative Nausea and Vomiting
Interventions: Drug: APD421; Drug: Placebo; Drug: Ondansetron
Sponsor: Acacia Pharma Ltd
Completed - Condition: Autism Spectrum Disorder
Interventions: Drug: Arbaclofen_15; Drug: Arbaclofen_30; Drug: Placebo
Sponsor: King's College London
Recruiting - Condition: Allergy
Intervention: Drug: Amoxicillin
Sponsor: The Leeds Teaching Hospitals NHS Trust
Completed - Condition: Dementia Alzheimers
Intervention: Other: Standard Diet
Sponsors: University of Aberdeen; NHS Grampian; Tenovus Scotland
Recruiting - Condition: Pregnancy
Intervention: Other: Melatonin analysis
Sponsors: University of Aberdeen; NHS Grampian
Recruiting - Condition: Healthy
Interventions: Other: Oral Placebo; Other: Oral Protein; Other: Enteral Protein
Sponsor: University of Exeter
Recruiting - Condition: Healthy Adults
Interventions: Dietary Supplement: Tomato, onion & lovage soup with inulin; Dietary Supplement: Tomato, onion & lovage soup; Dietary Supplement: Inulin
Sponsors: University of Glasgow; Scottish Universities Environmental Research Centre
Recruiting - Condition: Overweight and Obesity
Interventions: Behavioral: Attentive eating smartphone application.; Behavioral: Standard dietary advice and text tips.
Sponsors: University of Liverpool; University of Birmingham; University of Oxford
Completed - Conditions: Molecular Mechanisms of Pharmacological Action; Depression; Depressive Disorder; Mood Disorders; Mental Disorders; Antidepressive Agents; Cognition
Interventions: Drug: Prucalopride; Other: Placebo
Sponsor: University of Oxford
Not yet recruiting - Condition: Dyslipidemias
Interventions: Drug: NST-4016 600mg; Drug: Placebo oral capsule; Drug: Moxifloxacin 400mg; Drug: NST-4016 2000mg
Sponsor: NorthSea Therapeutics B.V.
Recruiting - Condition: HIV Infections
Interventions: Drug: GSK3640254 bis-hydrochloride salt capsule; Drug: GSK3640254 Mesylate Salt Capsule
Sponsor: ViiV Healthcare
Completed - Condition: Type1diabetes
Interventions: Behavioral: high intensity interval training; Behavioral: moderate intensity continous training
Sponsors: Liverpool John Moores University; Society for Endocrinology; Royal Liverpool University Hospital; University of Birmingham; University of Exeter
Not yet recruiting - Conditions: Sloughing Skin; Mucosal Inflammation
Intervention: Other: Treatment
Sponsors: Unilever R&D; University of Birmingham
Completed - Condition: Cicatrix, Hypertrophic
Interventions: Drug: OLX10010; Drug: Placebo
Sponsor: Olix Pharmaceuticals, Inc.
Recruiting - Condition: Amyloidosis
Interventions: Drug: GSK3039294; Drug: Placebo
Sponsor: GlaxoSmithKline
Withdrawn - Condition: Physical Activity
Intervention: Behavioral: Physical Education (PE) programme
Sponsors: University of Oxford; Oxford Brookes University
Enrolling by invitation - Condition: Healthy Overweight
Intervention: Other: raspberry powder, milled flaxseed and soy milk
Sponsors: King's College London; The National Processed Raspberry Council
Recruiting - Condition: Stress, Psychological
Interventions: Other: Guided Imagery Relaxation Tape; Other: Music Listening; Other: Relaxation Lighting; Other: Meditation and Relaxation Light; Other: Music and Relaxation Light; Other: Control/Silence
Sponsor: University College, London
Completed - Condition: Healed Ulcer
Intervention: Other: Intellin smart phone application
Sponsors: Natalie Garratt; Innovate UK; Gendius Limited
Enrolling by invitation - Condition: Pregnancy Testing
Intervention: Diagnostic Test: home pregnancy test
Sponsor: SPD Development Company Limited
Active, not recruiting - Conditions: Cognitive Change; Effects of Ginseng on Cognitive Function
Interventions: Dietary Supplement: Cereboost; Dietary Supplement: Placebo
Sponsors: University of Reading; Naturex
Recruiting - Condition: Fatty Acid Oxidation
Intervention: Other: Dietary fatty acid partitioning
Sponsor: University of Oxford
Recruiting - Condition: Healthy
Interventions: Other: Low nucleotide meal; Other: High nucleotide meal
Sponsor: University of Exeter
Completed - Condition: Healthy Volunteer
Interventions: Drug: CC-99677; Other: Placebo
Sponsor: Celgene
Recruiting - Conditions: Appetitive Behavior; Individual Difference; Food Sensitivity; Food Preferences
Intervention: Behavioral: Expanded Corn Snack
Sponsors: University of Reading; University of Sussex; Quadram Institute; Unilever R&D; PepsiCo Global R&D; Mondelēz International, Inc.; Arla Foods; Mars, Inc.
Not yet recruiting - Condition: Sleep
Interventions: Dietary Supplement: EPA-rich; Dietary Supplement: DHA-rich; Dietary Supplement: Olive oil Placebo
Sponsors: Northumbria University; BASF
Completed - Condition: Healthy Men and Women
Interventions: Dietary Supplement: Placebo; Dietary Supplement: Concord Grape extract 1; Dietary Supplement: Concord Grape extract 2
Sponsors: King's College London; Naturex-Dbs
Recruiting - Condition: Constipation
Intervention: Device: MiniCap
Sponsors: Nottingham University Hospitals NHS Trust; University of Nottingham
Recruiting - Condition: Renal Disease
Interventions: Other: 3 Tesla multiparametric MR; Other: renal histopathology scoring; Biological: Blood and urine sampling; Biological: Iohexol clearance test
Sponsor: University of Nottingham
Recruiting - Condition: Menopause
Intervention: Drug: Estrogel
Sponsors: Viramal Limited; Simbec Research
Recruiting - Conditions: Human Microbiome; Eating Behavior
Interventions: Dietary Supplement: Intervention snack 1; Dietary Supplement: Intervention snack 2; Dietary Supplement: Control snack
Sponsors: King's College London; Queen Mary University of London; University of Liverpool
Recruiting - Condition: Muscle Disuse Atrophy
Intervention: Procedure: Eccentric exercise
Sponsor: University of Exeter
Recruiting - Condition: Myeloma
Intervention: Other: Machine Learning (ML)
Sponsors: Royal Marsden NHS Foundation Trust; Institute of Cancer Research, United Kingdom; Imperial College London
Recruiting - Condition: Exposure to Medical Diagnostic Radiation
Interventions: Other: 18-F FDG PET/CT dosimetry scans and measurements; Other: Ga-68 PSMA PET/CT dosimetry scans and measurements; Other: 68-Ga Dotatate PET/CT dosimetry scans and measurements; Other: 99mTc Pertechnetate Thyroid dosimetry scans and measurements; Other: 99mTc DMSA(III) Renal dosimetry scans and measurements; Other: 99mTc MAG3 Renal dosimetry scans and measurements; Other: 99mTc MDP Bone dosimetry scans and measurements
Sponsor: Royal Marsden NHS Foundation Trust
Recruiting - Conditions: Male Infertility; Obesity; Weight Loss
Interventions: Dietary Supplement: Low Energy Diet; Other: NHS advice on healthy eating
Sponsor: Imperial College London
Recruiting - Condition: Cystic Fibrosis
Intervention: Diagnostic Test: MRI scans
Sponsor: Nottingham University Hospitals NHS Trust
Recruiting - Condition: Breast Milk Collection
Intervention: Other: Laboratory analysis
Sponsor: Bournemouth University
Not yet recruiting - Condition: Physical Activity and Wellbeing
Intervention: Behavioral: Urban street greening
Sponsor: University of Manchester
Active, not recruiting - Conditions: Physical Activity; Diet Modification
Intervention: Other: Diet
Sponsor: University of Bath
Not yet recruiting - Condition: Asthma
Interventions: Diagnostic Test: Indirect bronchial challenge; Other: Sham bronchial challenge
Sponsors: University of East Anglia; University of Manchester; Asthma UK Centre for Applied Research
Enrolling by invitation - Conditions: Whooping Cough; Maternal Vaccine Exposure; Immunization; Infection
Intervention: Biological: Pre-school booster vaccine
Sponsors: St George's, University of London; University of Oxford; University Hospitals Bristol NHS Foundation Trust
Recruiting - Condition: Eating Disorders in Adolescence
Intervention: Other: Cognitive Bias Modification
Sponsors: King's College London; South London and Maudsley NHS Foundation Trust; South West London and St George's Mental Health NHS Trust; Ellern Mede Ridgeway
Recruiting - Conditions: Psoriasis; Atopic Dermatitis
Interventions: Other: EDP1066; Drug: Placebo oral capsule
Sponsor: Evelo Biosciences, Inc.
Recruiting - Condition: Diet Modification
Interventions: Other: Improved product placement of fresh fruit and vegetables; Other: Sham comparator
Sponsors: University Hospital Southampton NHS Foundation Trust; University of Southampton; Medical Research Council
Recruiting - Effect of Drinks Containing Fruit Polyphenol Extracts and Fibre on Postprandial Glycaemia. (Glu-MIX)Condition: Postprandial Period
Interventions: Dietary Supplement: Placebo; Dietary Supplement: Polyphenol and fibre; Dietary Supplement: Fibre
Sponsors: Lucozade Ribena Suntory; King's College London
Recruiting - Condition: Hypertrophy
Intervention: Other: Diet
Sponsors: University of Exeter; Quorn Foods
Recruiting - Conditions: Hyperprolactinemia; Subfertility; Subclinical hypothyroïdism
Intervention: Diagnostic Test: MRI Pituitary
Sponsor: University Hospitals Coventry and Warwickshire NHS Trust
Completed - Conditions: Inflammation; Obesity; Inflammatory Response; Cardiovascular Diseases
Intervention: Other: High Fat Diet
Sponsor: Loughborough University
Recruiting - Condition: Acute Cough
Interventions: Drug: Gefapixant; Drug: Placebo
Sponsor: Merck Sharp & Dohme Corp.
Recruiting - Conditions: Prebiotics; Anxiety; Humans; Magnetic Resonance Imaging; Decision Making; Emotion; Cortisol
Interventions: Dietary Supplement: Prebiotics; Dietary Supplement: Maltodextrin (placebo)
Sponsors: University of Oxford; National Health and Medical Research Council, Australia; Oxford Health Biomedical Research Centre (OH BRC) support scheme; Wellcome Centre for Integrative Neuroimaging; Monash University
Recruiting - Condition: Cardiovascular Diseases
Intervention:
Sponsors: NHS Greater Glasgow and Clyde; University of Glasgow
Recruiting - Condition: Pharmacokinetic Study in Healthy Male Volunteers
Interventions: Drug: Orvepitant; Drug: Itraconazole
Sponsor: Nerre Therapeutics Ltd.
Completed - Conditions: Inflammatory Bowel Diseases; Crohn Disease; Ulcerative Colitis
Intervention: Other: No intervention
Sponsors: PIBD-Net; European Commission
Recruiting - Condition: Cough
Interventions: Drug: BAY1902607; Drug: Matching placebo; Drug: Midazolam
Sponsor: Bayer
Recruiting - Condition: PHYSICAL FITNESS
Interventions: Device: Exercise app: 7 Minute Workout Challenge; Device: Running app: One You Couch to 5K
Sponsors: University College, London; Medical Research Council
Active, not recruiting - Condition: Healthy
Interventions: Drug: Placebo; Drug: Lu AF76432
Sponsor: H. Lundbeck A/S
Recruiting - Condition: Type 2 Diabetes Mellitus
Intervention: Behavioral: Physical activity
Sponsors: University of Leicester; University Hospitals, Leicester
Not yet recruiting - Conditions: Adolescent Behavior; Child Behavior; Parents
Intervention:
Sponsor: Institute of Child Health
Not yet recruiting - Conditions: Pollution; Exposure; Health Behavior
Intervention: Behavioral: Alternative health advice
Sponsors: King's College London; National Institute for Health Research, United Kingdom; Public Health England
Completed - Condition: Menopause
Intervention: Dietary Supplement: Alpro soya drinks
Sponsors: University of Ulster; Alpro Foundation
Completed - Condition: Sedentary Lifestyle
Intervention: Behavioral: Breaking up sitting
Sponsor: University of Bedfordshire
Active, not recruiting - Condition: Meningitis, Meningococcal
Intervention: Biological: Neisseria lactamica
Sponsors: University Hospital Southampton NHS Foundation Trust; University of Southampton
Recruiting - Conditions: Physical Activity; Health Behavior
Intervention: Behavioral: HealthyKidz physical activity programme
Sponsor: Queen's University, Belfast
Active, not recruiting - Condition: Autism Spectrum Disorder
Interventions: Drug: PLC; Drug: CBD; Drug: CBDV
Sponsor: King's College London
Active, not recruiting - Condition: Type2 Diabetes
Interventions: Behavioral: HEAL-D; Behavioral: Control
Sponsors: King's College London; University College, London
Recruiting - Conditions: Drug Drug Interaction; Autoimmune Diseases; Fibrotic Disease
Interventions: Drug: KD025; Drug: Itraconazole; Drug: Rabeprazole; Drug: Rifampicin; Drug: Omeprazole
Sponsors: Kadmon Corporation, LLC; Quotient Sciences
Recruiting - A Study to Compare the Pharmacokinetics of Different Oral Formulations of FDL169 in Healthy SubjectsCondition: Cystic Fibrosis
Intervention: Drug: FDL169
Sponsor: Flatley Discovery Lab LLC
Recruiting - Condition: Anesthesia
Intervention: Drug: Oxygen
Sponsor: University Hospital Southampton NHS Foundation Trust
Recruiting - Conditions: Child; Child Development; Health Behavior; Physical Activity
Interventions: Behavioral: Linear; Behavioral: Nonlinear
Sponsors: Liverpool John Moores University; University of Münster; University of Strathclyde; University of Otago; Victoria University; Newcastle University; University of Rome Foro Italico
Active, not recruiting - Condition: Gestational Diabetes
Interventions: Dietary Supplement: Guar gum; Dietary Supplement: Cellulose
Sponsor: Imperial College London
Recruiting - Condition: Hepatitis B
Interventions: Biological: Hepatitis B; Biological: Tetanus Toxoid
Sponsor: Imperial College London
Completed - Conditions: Food Preferences; Hunger
Intervention: Behavioral: Food labelling versus no food labelling
Sponsor: St Mary's University College
Recruiting - Condition: Type1diabetes
Intervention: Behavioral: Effects of the type of exercise on blood glucose concentrations
Sponsor: Liverpool John Moores University
Completed - Condition: Healthy
Interventions: Drug: GLPG1690; Drug: Itraconazole; Drug: Voriconazole
Sponsor: Galapagos NV
Completed - Conditions: COPD With Hyperinflation; Diaphragmatic Weakness
Intervention: Diagnostic Test: Upright MRI
Sponsor: University of Nottingham
Recruiting - Condition: Atopic Dermatitis
Interventions: Drug: LEO 138559; Drug: LEO 138559 placebo
Sponsor: LEO Pharma
Recruiting - Condition: Healthy Volunteer
Intervention: Drug: [14C] MT-7117
Sponsor: Mitsubishi Tanabe Pharma Development America, Inc.
Completed - Condition: Cystic Fibrosis
Intervention: Drug: FDL176 & FDL169 coadministration
Sponsor: Flatley Discovery Lab LLC
Recruiting - Condition: Effect of Food on Postprandial Hyperglycemia
Interventions: Other: control; Other: test meal 1; Other: test meal 2; Other: test meal 3
Sponsor: University of Leeds
Completed - Conditions: Cognitive Function; Mood
Interventions: Dietary Supplement: CP9700; Dietary Supplement: Matched Placebo
Sponsors: University of Reading; Polyphenolics, Inc.
Active, not recruiting - Condition: Pelvic Girdle Pain
Intervention: Device: GreenBone implant
Sponsors: PeterGiannoudis; University of Leeds
Not yet recruiting - Condition: Scarring
Interventions: Procedure: Incision; Drug: Active gel; Drug: Placebo gel
Sponsors: University Hospitals, Leicester; Leicester Clinical Trials Unit; University of Leicester; Medical Research Council
Recruiting - Condition: Healthy
Interventions: Drug: CORT125134; Drug: Matching Placebo of CORT125134; Drug: Mifegyne®; Drug: Prednisone; Drug: Glucose
Sponsor: Corcept Therapeutics
Completed - Conditions: Paroxysmal Atrial Fibrillation; Atrial Fibrillation
Intervention: Procedure: Radiofrequency ablation
Sponsor: Imperial College London
Recruiting - Condition: Asthma
Intervention: Behavioral: My Asthma in School
Sponsor: Queen Mary University of London
Recruiting - Condition: Stroke, Acute
Intervention:
Sponsor: Royal Devon and Exeter NHS Foundation Trust
Recruiting - Conditions: Osteoarthritis, Knee; Rheumatoid Arthritis; Spondyloarthritis; Psoriatic Arthritis
Intervention: Procedure: Intra-articular corticosteroid injection
Sponsors: St George's, University of London; Wellcome Trust; Rosetrees Trust
Recruiting - Condition: Postoperative Pain
Interventions: Drug: TAP Block; Drug: Control
Sponsor: Royal Devon and Exeter NHS Foundation Trust
Recruiting - Condition: Smoking Cessation
Intervention: Drug: cytisine
Sponsor: Achieve Life Sciences
Completed - Condition: Nutrition
Intervention: Other: Metabolic test meal challenge
Sponsor: King's College London
Recruiting - Condition: Healthy Volunteers
Interventions: Biological: TDV; Biological: Placebo; Biological: HAV Vaccine
Sponsor: Takeda
Recruiting - Condition: The Well Being of Parents of Children With Food Allergies
Intervention: Other: Online self-help
Sponsors: Canterbury Christ Church University; Brighton & Sussex Medical School
Enrolling by invitation - Condition: Contraception
Interventions: Drug: E4/DRSP; Drug: VAL
Sponsors: Estetra; Quotient Sciences
Recruiting - Condition: Obesity
Interventions: Other: MRI; Other: Written Consent
Sponsor: University College, London
Recruiting - Condition: Healthy Volunteers
Interventions: Biological: ABY-039; Biological: Placebo
Sponsors: Affibody; Parexel
Recruiting - Condition: Autism Spectrum Disorder
Interventions: Drug: RO7017773; Other: [11C] Ro15-4513
Sponsor: Hoffmann-La Roche
Completed - Conditions: Hepatitis C; Infectious Disease
Intervention:
Sponsor: University College, London
Recruiting - Condition: Healthy Subjects
Intervention: Drug: pracinostat
Sponsors: Helsinn Healthcare SA; Quotient Sciences
Enrolling by invitation - Conditions: Smoking Cessation; Diabetes Mellitus, Type 2
Intervention: Behavioral: Financial incentives
Sponsors: University of Oklahoma; Cancer Research UK; University of Strathclyde; University College, London
Recruiting - Condition: Cardiovascular Diseases
Interventions: Other: risk-framed leaflet; Other: benefits-framed leaflet; Other: current national leaflet
Sponsor: Public Health England
Enrolling by invitation - Conditions: Diabetes Mellitus; Healthy Volunteers
Interventions: Device: Frazier 3 Verio; Device: Frazier 3 UltraPlus
Sponsors: LifeScan; Institute for Diabetes-Technology GmbH
Recruiting - Conditions: Cardiovascular Diseases; Coronary Heart Disease
Intervention: Other: There is no intervention
Sponsors: Imperial College London; European Society of Cardiology
Recruiting - Condition: Lower Urinary Tract Symptoms
Intervention: Diagnostic Test: Urodynamics
Sponsors: Cardiff University; Newcastle-upon-Tyne Hospitals NHS Trust; University of Birmingham
Recruiting - Conditions: Cholestasis of Pregnancy; Intrahepatic Cholestasis of Pregnancy; Obstetric Cholestasis
Intervention: Device: Monica AN24
Sponsors: Guy's and St Thomas' NHS Foundation Trust; King's College London
Recruiting - Condition: Pneumonia
Interventions: Procedure: Venepuncture; Procedure: Bronchoscopy
Sponsors: Royal Liverpool and Broadgreen University Hospitals NHS Trust; Aintree University Hospitals NHS Foundation Trust; Liverpool School of Tropical Medicine
Completed - Condition: Injury;Sports
Intervention:
Sponsor: Heriot-Watt University
Recruiting - Condition: Erectile Dysfunction
Interventions: Drug: Sublingual sildenafil; Drug: Oral sildenafil
Sponsors: N4 Pharma UK Ltd.; BDD Pharma Ltd
Completed - Condition: Physical Activity
Intervention: Other: Diet
Sponsor: University of Bath
Completed - Condition: Adrenal Suppression
Interventions: Drug: nasal Tetracosactide; Drug: IV tetracosactide
Sponsor: Sheffield Children's NHS Foundation Trust
Suspended - Condition: Postoperative Sensitivity of Existing Dental Filling Materials
Intervention: Device: Fill-Up composite resin
Sponsor: University of Leeds
Recruiting - Condition: Cystic Fibrosis
Interventions: Drug: VX-440; Drug: TEZ; Drug: IVA; Drug: Matched Placebos
Sponsor: Vertex Pharmaceuticals Incorporated
Completed - Condition: Redox Status
Intervention:
Sponsor: University of Southampton
Recruiting - Condition: Pain, Inflammatory
Interventions: Drug: GSK3858279 IV; Drug: GSK3858279 SC; Drug: Placebo matching GSK3858279 IV; Drug: Placebo matching GSK3858279 SC
Sponsor: GlaxoSmithKline
Recruiting - Conditions: Pneumonia; Influenza, Human
Interventions: Biological: Study one: LAIV + Inoculation; Biological: Study one: Placebo + Inoculation; Biological: Study two: Inoculation + LAIV; Biological: Study two: Inoculation + placebo
Sponsors: Royal Liverpool and Broadgreen University Hospitals NHS Trust; Sponsor GmbH; Liverpool School of Tropical Medicine
Completed - Conditions: SVT; Vagal Bradycardia; Emergencies
Interventions: Other: Standard Care; Device: Valsalva Assist Device (VAD)
Sponsors: South Western Ambulance Service NHS Foundation Trust; Royal Devon and Exeter NHS Foundation Trust; Academic Health Science Centres
Recruiting - Condition: Cytomegalovirus Congenital
Intervention: Behavioral: Hygiene based educational film
Sponsors: St George's, University of London; University College, London; Kingston University; University of Cambridge; CMV Action
Recruiting - Condition: Asthma
Interventions: Drug: Itraconazole Powder; Drug: Itraconazole 200 mg
Sponsor: Pulmatrix Inc.
Completed - Condition: Behavior, Consumer
Interventions: Other: Population Sample; Other: Purposive sample
Sponsor: ThinkWell
Enrolling by invitation - Conditions: Muscle Atrophy; Insulin Sensitivity
Interventions: Other: Bed Rest; Other: Reconditioning
Sponsor: University of Nottingham
Recruiting - Conditions: Cardiovascular Disease; Pulmonary Arterial Hypertension; Heart Failure
Interventions: Drug: BIA 5-1058; Drug: Placebo Oral Tablet; Drug: Moxifloxacin 400 mg
Sponsors: Bial - Portela C S.A.; Covance
Active, not recruiting - Condition: Pharmacokinetics
Interventions: Drug: Padsevonil (UCB0942); Drug: Erythromycin
Sponsor: UCB Biopharma S.P.R.L.
Completed - Conditions: Fever; Infection; Inflammation
Interventions: Diagnostic Test: Validation of biomarker; Other: Antibiotic prescription; Other: re-attendance at ED; Other: Hospitalisation
Sponsors: Imperial College London; Servizo Galego de Saúde; London School of Hygiene and Tropical Medicine; University of Liverpool; University of Newcastle Upon-Tyne; ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM; Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA); National and Kapodistrian University of Athens; Stichting Katholieke Universiteit; University of Graz; University of Ljubljana; Riga Stradiņs University; Medical Research Council Unit, The Gambia; Ludwig-Maximilians - University of Munich; University of Bern; University of Oxford; University Hospital, Paris
Recruiting - Condition: Healthy
Interventions: Dietary Supplement: Single dose fish oil; Dietary Supplement: Repeated dose fish oil; Dietary Supplement: single dose Camelina seed oil; Dietary Supplement: repeated dose camelina seed oil
Sponsor: University of Southampton
Recruiting - Condition: Intestinal Transit
Interventions: Drug: Loperamide; Drug: Senna
Sponsor: University Hospital Plymouth NHS Trust
Not yet recruiting - Conditions: Atrial Fibrillation; Heart Murmurs
Intervention: Device: Rapid Rhythm Handheld 8-lead ECG Device
Sponsors: Manchester University NHS Foundation Trust; Rapid Rhythm Ltd
Recruiting - Conditions: Behavior, Adaptive; Decision Analysis
Interventions: Behavioral: presentation order; Behavioral: alternative presentation order
Sponsor: ThinkWell
Enrolling by invitation - Condition: Periodontal Diseases
Interventions: Device: Hand Instrumentation Treatment; Device: Ultrasonic Instrumentation Treatment
Sponsor: University of Glasgow
Recruiting - Conditions: Cognitive Function; Urinary Metabolites; Intestinal Microbiota
Interventions: Other: Nut components; Other: Placebo
Sponsors: Northumbria University; International Nut and Dried Fruit Council
Recruiting - Condition: Healthy Volunteer
Interventions: Drug: MT-8554 Low dose; Drug: MT-8554 High dose; Drug: Placebo
Sponsor: Mitsubishi Tanabe Pharma Development America, Inc.
Recruiting - Conditions: Blood Pressure; Cognitive Change; Functional Capacity; Brain Metabolism
Interventions: Dietary Supplement: Nitrate-rich beetroot juice; Dietary Supplement: Nitrate-depleted beetroot juice
Sponsor: University of Exeter
Completed - Condition: Healthy Subjects
Intervention: Drug: CP1050 or Placebo
Sponsor: Curadim Pharma Co., Ltd.
Enrolling by invitation - Condition: Osteoarthritis, Knee
Interventions: Other: Ice Pack and Cooling Device; Drug: CNTX-4975-05 (trans-capsaicin); Drug: Capsaicin
Sponsor: Centrexion Therapeutics
Recruiting - Conditions: Cancer; Cardiovascular Diseases
Intervention: Other: Photoacoustic tomography
Sponsor: University College, London
Recruiting - Condition: Breast Neoplasm Malignant Breast Tissue
Interventions: Other: Magnetic Resonance Imaging; Other: Histopathological Analysis; Other: Health Questionnaire
Sponsors: University of Aberdeen; NHS Grampian
Recruiting - Conditions: Gastric Retention; Healthy
Interventions: Drug: Memantine Hydrochloride MR Prototype Capsule Formulation A; Drug: Memantine Hydrochloride MR Prototype Capsule Formulation B; Drug: Memantine Hydrochloride MR Prototype Capsule Formulation C; Drug: Memantine Hydrochloride MR Prototype Capsule Formulation D; Drug: Memantine Hydrochloride MR Prototype Capsule Formulation E; Procedure: Magnetic Resonance Imaging
Sponsor: Lyndra Inc.
Terminated - Conditions: Cognitive Change; Affect; Blood Pressure; Neuroimaging
Interventions: Dietary Supplement: Sideritis Scardica; Dietary Supplement: Ginkgo biloba; Dietary Supplement: Placebo control
Sponsors: Northumbria University; Finzelberg
Completed - Conditions: Skin Cancer; Dermatology/Skin - Other
Interventions: Device: Barco NV Digital Dermatoscope device images; Device: Standard medical photographs including dermoscopy images; Other: Clinic proforma completion
Sponsor: Barco NV
Recruiting - Condition: Healthy Subjects
Interventions: Drug: nangibotide; Drug: Placebo
Sponsors: Inotrem; Richmond Pharmacology Limited
Completed - Condition: Healthy Subjects
Interventions: Drug: BOS172767 tablets; Drug: BOS172767 liquid capsules; Drug: BOS172767 micronized capsules; Drug: BOS172767 immediate release capsules; Drug: BOS172767 matching placebo capsules; Drug: BOS172767 matching placebo tablets; Drug: Rabeprazole
Sponsor: Boston Pharmaceuticals
Recruiting - Condition: Healthy Male Volunteers
Interventions: Drug: XPF-008; Drug: Microcrystalline Cellulose
Sponsor: Xenon Pharmaceuticals Inc.
Completed - Condition: Healthy Volunteers
Interventions: Drug: XEN901; Drug: Inert Ingredients Oral Product
Sponsor: Xenon Pharmaceuticals Inc.
Recruiting - Condition: Pre-Diabetes
Intervention: Behavioral: Consultation
Sponsors: Aberystwyth University; Hywel Dda Health Board
Active, not recruiting - Condition: IBD
Intervention: Drug: Alicaforsen
Sponsor: Atlantic Pharmaceuticals Ltd
Active, not recruiting - Conditions: Cerebellar Mutism; Posterior Fossa Syndrome
Intervention: Diagnostic Test: Advanced MRI sequences
Sponsor: Great Ormond Street Hospital for Children NHS Foundation Trust
Recruiting - Conditions: Diabetes; Heart Diseases; Diet Habit; Diet Modification; Microbial Colonization; Healthy; Healthy Obesity, Metabolically
Intervention: Other: Dietary intervention
Sponsors: Guy's and St Thomas' NHS Foundation Trust; King's College London
Recruiting - Condition: Chronic Pain Including Neuropathic Pain
Interventions: Drug: BIIB095; Drug: Placebo
Sponsor: Biogen
Recruiting - Condition: High-Intensity Interval Training
Intervention: Other: High-intensity interval training
Sponsor: University of Nottingham
Recruiting - Condition: Healthy Volunteers
Interventions: Drug: AZD9977 Oral suspension (reference); Drug: AZD9977 capsule; Drug: AZD9977 ER capsule (fastvrate); Drug: AZD9977 ER capsule (Int. rate)
Sponsors: AstraZeneca; Parexel
Completed - Condition: Type 2 Diabetes Mellitus
Intervention: Behavioral: Reducing/breaking prolonged sitting
Sponsors: University of Leicester; University Hospitals, Leicester; Loughborough University; Baker IDI Heart and Diabetes Institute
Recruiting - Condition: Healthy
Intervention: Drug: Evenamide
Sponsor: Newron Pharmaceuticals SPA
Recruiting - Condition: Hypothermia
Intervention: Device: Geratherm non Contact thermometer
Sponsor: Brighton and Sussex University Hospitals NHS Trust
Not yet recruiting - Condition: Training Group, Sensitivity
Intervention: Device: Microcurrent
Sponsors: University of Greenwich; Arc Family
Recruiting - Condition: Cardiac Arrest
Intervention: Device: Pad positioning according to a manufacturer's diagram
Sponsor: University Hospital Southampton NHS Foundation Trust
Not yet recruiting - Condition: Metabolic Syndrome
Intervention: Other: High-intensity exergaming
Sponsors: Sheffield Hallam University; Teesside University; Northumbria University; Newcastle University
Completed - Condition: Healthy Male Participants
Intervention: Drug: [14C]-E6007
Sponsor: EA Pharma Co., Ltd.
Completed - Condition: Major Injury
Interventions: Behavioral: Face-to-face neurocognitive tests; Behavioral: Psychological screening; Other: fMRI; Behavioral: Quality of Life Self-Assessment data
Sponsors: Chelsea and Westminster NHS Foundation Trust; Imperial College Healthcare NHS Trust; University of Westminster
Completed - Condition: Respiratory Physiology
Intervention: Other: High G acceleration on a long-arm human centrifuge
Sponsors: King's College London; University of Oxford; QinetiQ Ltd; UK Space Agency
Completed - Conditions: Anorexia Nervosa in Remission; Eating Disorder
Intervention: Other: Volatility task
Sponsor: University of Oxford
Completed - Condition: Stroke, Ischemic
Intervention:
Sponsor: Cambridge University Hospitals NHS Foundation Trust
Not yet recruiting - Condition: Orthodontic Appliance Complication
Interventions: Device: 3M Unitek Victory Series™ Superior Fit Buccal Tube with APC™ Flash-Free Adhesive. 4069-6103 / 4069-6114 / 4069-6203 / 4069-6214; Device: 3M Unitek Victory Series™ Superior Fit Buccal Tube with APC™ II Adhesive. 3069-6103 / 3069-6114 / 3069-6203 / 3069-6214
Sponsor: Guy's and St Thomas' NHS Foundation Trust
Completed - Conditions: Cardiovascular Diseases; Type 2 Diabetes Mellitus
Interventions: Drug: Apelin; Drug: Relaxin; Drug: Normal saline; Diagnostic Test: Verapamil; Diagnostic Test: LN Monomethyl arginine
Sponsors: Cambridge University Hospitals NHS Foundation Trust; University of Cambridge; AstraZeneca; MedImmune LLC
Recruiting - Conditions: Stroke; Cerebrovascular Accident; Stress; Anxiety; Depression
Intervention: Other: Web-based Mindfulness Course
Sponsor: Glasgow Caledonian University
Not yet recruiting - Conditions: Corneal Thickness Measurement; Epithelial Thickness Measurement; LASIK Flap Thickness Measurement; SMILE Cap Thickness Measurement
Interventions: Device: ArcScan Insight 100 very high-frequency digital ultrasound; Device: Carl Zeiss Meditec Cirrus HD OCT 5000; Device: Optovue RTVue OCT; Device: CSO MS-39 OCT
Sponsors: London Vision Clinic; Carl Zeiss Meditec AG
Not yet recruiting - Conditions: Eating Behavior; Hunger; Inhibition; Functional Magnetic Resonance Imaging
Intervention: Other: Break-Lunch time
Sponsor: University of Birmingham
Completed - Conditions: Loneliness; Ageing; Physical Activity
Intervention: Behavioral: Group walking and group educational workshops
Sponsor: University of Birmingham
Recruiting - Conditions: Cognitive Function and Mood; Cerebral Blood Flow; Systemic Inflammation; Gut Microbiota; Overweight and Obesity
Interventions: Dietary Supplement: Resveratrol; Dietary Supplement: Placebo
Sponsors: Northumbria University; Evolva SA
Recruiting - Conditions: Anorexia Nervosa in Remission (Disorder); Compulsive Behavior
Intervention: Other: MRI
Sponsor: University of Oxford
Completed - Condition: Healthy Volunteers
Interventions: Drug: AZD9977; Other: Placebo
Sponsors: AstraZeneca; Parexel
Completed - Condition: Coronary Artery Disease
Interventions: Diagnostic Test: PET/MRI; Diagnostic Test: MRI
Sponsor: University of Edinburgh
Recruiting - Conditions: Mood; Salt Intake
Interventions: Dietary Supplement: Sodium Chloride; Other: Placebo capsule; Dietary Supplement: Water; Biological: No water consumed
Sponsor: Swansea University
Recruiting - Condition: High-intensity Interval Training
Intervention: Behavioral: High-intensity interval training
Sponsor: Teesside University
Active, not recruiting - Condition: Visual Acuity
Interventions: Device: Test Eye Drops; Device: Control Eye Drops
Sponsor: Johnson & Johnson Vision Care, Inc.
Completed - Conditions: Cardiovascular Health; Identify Oral Bacteria Responsible for Nitrate Reduction
Interventions: Dietary Supplement: Nitrate-rich beetroot juice; Dietary Supplement: Nitrate-depleted beetroot juice; Other: Mouthwash
Sponsor: University of Exeter
Recruiting - Condition: Frozen Shoulder
Interventions: Procedure: arthroscopic capsular release; Procedure: Hydro-dilatation
Sponsor: Royal Devon and Exeter NHS Foundation Trust
Completed - Condition: Vitamin D Deficiency
Interventions: Dietary Supplement: vitamin D3; Dietary Supplement: Pill; Dietary Supplement: orange syrup; Other: mineral oil; Dietary Supplement: Penetrator
Sponsors: University of Wolverhampton; Royal National Orthopaedic Hospital NHS Trust; University of Worcester
Completed - Conditions: Prehypertension; Healthy
Interventions: Dietary Supplement: Placebo; Dietary Supplement: Aronia extract
Sponsors: King's College London; Naturex-Dbs
Recruiting - Condition: Cognitive Flexibility
Interventions: Combination Product: Sham tDCS and tyrosine depleted drink; Combination Product: Anodal tDCS and tyrosine depleted drink; Combination Product: Sham tDCS and balanced drink; Combination Product: Anodal tDCS and balanced drink
Sponsor: Sheffield Hallam University
Completed - Condition: Healthy Adults
Interventions: Dietary Supplement: Interesterified fat; Dietary Supplement: Non- interesterified fat; Dietary Supplement: Rapeseed oil
Sponsor: King's College London
Not yet recruiting - Condition: Healthy Participants
Interventions: Drug: BMS-986278; Other: Placebo
Sponsor: Bristol-Myers Squibb
Recruiting - Condition: Sarcopenia
Interventions: Dietary Supplement: Phosphatidic Acid; Dietary Supplement: Rice flour
Sponsors: University of Birmingham; University of Nottingham
Completed - Condition: Pruritus
Intervention: Device: Seirin Pyonex press needle acupuncture
Sponsors: Sheffield Teaching Hospitals NHS Foundation Trust; Obstetric Anaesthetist's Association
Recruiting - Conditions: Aging; Cognitive Decline
Interventions: Behavioral: Intermittent Energy Restriction; Behavioral: Chewing; Behavioral: Chewing + Intermittent Energy Restriction
Sponsors: King's College London; Medical Research Council; Mars, Incorporated
Recruiting - Conditions: Skeletal Scintigraphy; FDG PET/CT
Intervention: Other: Self-administered questionnaire
Sponsors: Royal Marsden NHS Foundation Trust; City, University of London
Active, not recruiting - Conditions: Infant Formula; Growth
Interventions: Other: Modified infant formula; Other: Standard infant formula
Sponsors: Nestlé; University College, London
Recruiting - Condition: Cystic Fibrosis
Intervention: Drug: FDL169
Sponsor: Flatley Discovery Lab LLC
Completed - Condition: Gastroesophageal Reflux
Intervention: Device: Bravo
Sponsor: Guy's and St Thomas' NHS Foundation Trust
Not yet recruiting - Condition: Arthritis, Rheumatoid
Interventions: Drug: Placebo; Drug: GSK3358699; Biological: GM-CSF; Biological: LPS; Other: Cantharidin
Sponsor: GlaxoSmithKline
Recruiting - Condition: Healthy
Interventions: Drug: AL-794; Drug: Placebo
Sponsor: Alios Biopharma Inc.
Terminated - Condition: Overweight and Obesity
Interventions: Behavioral: Alternate Day Fasting; Behavioral: Continuous dietary restriction
Sponsors: University of Leeds; University of Illinois at Chicago
Recruiting - Condition: Coronary Artery Disease
Interventions: Drug: Form 1 of AZD5718 tablets; Drug: Form 2 of AZD5718 tablets; Drug: Form 3 of AZD5718 tablets; Drug: Form 4 of AZD5718 tablets; Drug: Form 5 of AZD5718 tablets; Drug: Selected form (Form 2 - 5) of AZD5718 tablets
Sponsors: AstraZeneca; Parexel
Completed - Conditions: Metabolic Disease; Immune Function; Cardiovascular Diseases; Systemic Inflammation
Interventions: Dietary Supplement: Omega 3 fatty acid; Dietary Supplement: Inulin fibre
Sponsor: Guy's and St Thomas' NHS Foundation Trust
Active, not recruiting - Condition: Repeated Sweet Food Consumption
Interventions: Behavioral: Sweet food consumption; Behavioral: Non-sweet food consumption
Sponsors: Bournemouth University; University of Bristol, UK
Recruiting - Conditions: Parkinson Disease; Parkinsonism
Intervention:
Sponsors: University College, London; European Commission; University of Luxembourg; University of Luebeck; Leiden University Medical Center
Recruiting - Condition: Atopic Dermatitis
Intervention: Device: BAY987534
Sponsor: Bayer
Not yet recruiting - Conditions: Cardiovascular Risk Factor; Lipemia
Interventions: Dietary Supplement: Galactose; Dietary Supplement: Glucose
Sponsor: University of Bath
Completed - Condition: Healthy
Interventions: Drug: JNJ-64417184; Drug: Placebo
Sponsor: Alios Biopharma Inc.
Recruiting - Conditions: Atherosclerosis; Diabetes; Coronary Artery Disease
Intervention: Device: diffuse optical tomography
Sponsors: Sheffield Teaching Hospitals NHS Foundation Trust; University of Sheffield
Recruiting - Condition: Healthy
Intervention: Drug: AK0529
Sponsor: Ark Biosciences Inc.
Completed - Conditions: Diet Records; Diet Surveys
Intervention: Other: no intervention - recoding of food recall only
Sponsors: University of Leeds; British Medical Research Council
Completed - Condition: Dementia
Intervention: Other: DRT Intervention
Sponsor: University of Nottingham
Completed - Condition: Human Immunodeficiency Virus
Interventions: Biological: Ad4-EnvCN54; Biological: MVA-CN54; Biological: CN54gp140/MPLA
Sponsor: Imperial College London
Recruiting - Condition: Repeated Sweet Food Consumption
Intervention: Behavioral: Sweet food consumption
Sponsors: Bournemouth University; University of Bristol, UK
Recruiting - Condition: Hypercholesterolemia
Interventions: Drug: CiVi007; Other: Placebo
Sponsor: Civi Biopharma, Inc.
Recruiting - Condition: Pregnancy
Intervention: Device: Clearblue Connected Ovulation Test System
Sponsor: SPD Development Company Limited
Active, not recruiting - Condition: MERS (Middle East Respiratory Syndrome)
Intervention: Biological: ChAdOx1 MERS
Sponsor: University of Oxford
Recruiting - Condition: Healthy
Interventions: Drug: Lu AF35700 5 mg clinical formulation; Drug: Lu AF35700 5 mg commercial formulation; Drug: Lu AF35700 10 mg clinical formulation; Drug: Lu AF35700 10 mg commercial formulation; Drug: Lu AF35700 20 mg clinical formulation; Drug: Lu AF35700 20 mg commercial formulation
Sponsor: H. Lundbeck A/S
Recruiting - Condition: Metabolic Disease
Interventions: Drug: PXL770; Drug: Placebo; Drug: Rosuvastatin
Sponsor: Poxel SA
Completed - Conditions: Respiratory Distress Syndrome, Adult; Critical Illness; Mechanical Ventilation Complication; Haemodynamic Instability; Gas Exchange Impairment
Intervention: Device: Inspiwave
Sponsor: University of Oxford
Recruiting - Condition: Immunization; Infection
Intervention: Other: nasal swab
Sponsor: Public Health England
Completed - Condition: Stroke
Intervention: Behavioral: Heel raise intervention
Sponsor: University of Winchester
Recruiting - Conditions: Post-Dural Puncture Headache; Low Pressure Headache
Intervention: Diagnostic Test: Thromboelastography
Sponsor: University Hospitals, Leicester
Completed - Condition: Carcinoma, Basal Cell
Intervention: Other: OCT Mapped
Sponsors: Michelson Diagnostics Ltd.; Skin Care Network Ltd.
Recruiting - Condition: Anterior Cruciate Ligament Injury
Interventions: Device: Light load BFR resistance training; Procedure: Heavy load resistance training
Sponsors: University College London Hospitals; St. Mary's University
Recruiting - Condition: Antimicrobial Effect
Interventions: Drug: HEXI-PREP By Clinell Wipes; Drug: Chloraprep; Drug: Placebos
Sponsor: Gama Healthcare Ltd.
Recruiting - Condition: Cough
Intervention: Drug: Ambroxol Hydrochloride
Sponsors: Hull and East Yorkshire Hospitals NHS Trust; Sanofi
Not yet recruiting - Conditions: Head and Neck Cancer; Radiotherapy Side Effect
Intervention:
Sponsor: King's College London
Recruiting - Condition: Dietary Modification
Interventions: Other: Coconut oil; Other: Butter; Other: Olive oil
Sponsor: University of Reading
Not yet recruiting - Conditions: Dietary Modification; Dietary Habits
Interventions: Behavioral: Non-personalised advice; Behavioral: Online personalised advice; Behavioral: Face-to-face personalised advice
Sponsor: University of Reading
Recruiting - Condition: Healthy Volunteers
Interventions: Drug: ACH-0144471 Modified Release Prototype 1; Drug: ACH-0144471 Modified Release Prototype 2; Drug: ACH-0144471 Modified Release Prototype 3; Drug: ACH-0144471 Modified Release Prototype 4; Drug: ACH-0144471 Modified Release Prototype 5
Sponsors: Achillion Pharmaceuticals; Quotient Sciences
Completed - Condition: Multiple Sclerosis
Intervention: Other: Incremental shuttle walk test
Sponsor: Queen Margaret University
Not yet recruiting - Condition: Laparoscopic Training
Interventions: Device: Computerized Laparoscopic Trainer; Device: Box trainer with eye patch
Sponsor: University of Nottingham
Completed - Condition: Healthy
Interventions: Dietary Supplement: Strawberry juice with Inulin; Dietary Supplement: Strawberry Juice; Dietary Supplement: Inulin
Sponsors: University of Glasgow; Scottish Universities Environmental Research Centre
Recruiting - Conditions: Diet Pattern Analysis; Environmental Impact; Nutrient Intakes; Cardio-metabolic Health; Dietary Cost
Intervention:
Sponsors: University of Reading; Dairy Council, United Kingdom
Completed - Condition: Atrial Fibrillation
Interventions: Drug: HBI-3000; Other: Placebo
Sponsors: HUYA Bioscience International; Quotient Clinical
Completed - Condition: Healthy Volunteers
Interventions: Drug: GDC-0334; Drug: Placebo
Sponsor: Genentech, Inc.
Recruiting - Condition: Exercise Metabolism Following Ethanol Ingestion
Intervention: Dietary Supplement: Ethanol
Sponsor: University of Bath
Recruiting - Condition: Healthy Volunteer
Intervention: Drug: [14C] MT-8554
Sponsor: Mitsubishi Tanabe Pharma Development America, Inc.
Completed - Condition: Dysphoria
Intervention: Device: Transcranial direct current stimulation (tDCS)
Sponsors: University of Oxford; Medical Research Council
Recruiting - Conditions: Food Habits; Food Preferences; Health Behavior; Diet Habit; Child Behavior
Interventions: Behavioral: Narrative; Behavioral: Experiential
Sponsors: University of Leeds; Economic and Social Research Council, United Kingdom; Purely Nutrition Ltd
Completed - Condition: Filariasis
Intervention: Drug: LSF emodepside (BAY 44-4400) oral solution (1mg/mL)
Sponsors: Drugs for Neglected Diseases; Bayer; Bill and Melinda Gates Foundation
Recruiting - Conditions: Asthma; Chronic Obstructive Pulmonary Disease
Interventions: Drug: CHF6366; Drug: Placebo CHF6366; Drug: umeclidinium bromide and vilanterol trifenatate
Sponsor: Chiesi Farmaceutici S.p.A.
Recruiting - Condition: Healthy Volunteers
Interventions: Drug: SPR741; Drug: Ceftazidime; Drug: Piperacillin/tazobactam; Drug: Aztreonam
Sponsors: Spero Therapeutics; Simbec Research; QPS
Completed - Condition: Healthy
Interventions: Biological: CSL730; Other: Placebo
Sponsor: CSL Behring
Active, not recruiting - Condition: Healthy Subjects
Interventions: Drug: ID-085; Drug: Placebo oral capsule
Sponsor: Idorsia Pharmaceuticals Ltd.
Recruiting - Condition: Malaria, Vivax
Interventions: Other: Plasmodium vivax infection; Procedure: Collection of 250mL blood from each volunteer (N=2)
Sponsor: University of Oxford
Recruiting - Condition: Respiratory Syncytial Virus Infections
Interventions: Drug: PC786; Drug: Placebo/vehicle
Sponsor: Pulmocide Ltd
Completed - Condition: Filariasis
Intervention: Drug: Emodepside (BAY 44-4400)
Sponsors: Drugs for Neglected Diseases; Bayer; Bill and Melinda Gates Foundation
Completed - Condition: Dysmenorrhea
Interventions: Device: Allay; Device: Placebo
Sponsors: Birmingham Women's NHS Foundation Trust; BioElectronics Corporation
Recruiting - Condition: Healthy Volunteers
Intervention: Drug: Varlitinib
Sponsor: Aslan Pharmaceuticals
Completed - Condition: Healthy Participants
Intervention: Drug: BMS-986205
Sponsor: Bristol-Myers Squibb
Completed - Condition: Primary Hyperoxaluria
Interventions: Drug: DCR-PHXC; Drug: Placebo
Sponsor: Dicerna Pharmaceuticals, Inc.
Recruiting - Condition: Healthy
Interventions: Drug: Midazolam; Drug: ID-082
Sponsor: Idorsia Pharmaceuticals Ltd.
Completed - Condition: Healthy Volunteers
Interventions: Drug: MEDI7219; Drug: Placebo; Drug: Formulation without Active Drug
Sponsor: MedImmune LLC
Recruiting - Condition: Healthy
Interventions: Other: Apple; Other: Oats; Dietary Supplement: Lactobacillus reuteri NCIMB 30242; Other: Cornflakes
Sponsors: University of Reading; University College Cork; Fondazione Edmund Mach; Università degli Studi dell'Insubria
Recruiting - Condition: Thrombosis
Intervention: Drug: BMS-986177
Sponsor: Bristol-Myers Squibb
Completed - Condition: Myopia
Interventions: Device: First pair Senofilcon A contact lens; Device: Second pair Senofilcon A contact lens; Device: Third pair Senofilcon A contact lens
Sponsors: Graeme Young; Visioncare Research Ltd.
Completed - Condition: Inflammatory Bowel Diseases
Interventions: Drug: GSK2983559; Drug: Placebo
Sponsor: GlaxoSmithKline
Recruiting - Conditions: Biliary Colic; Cholecystitis
Interventions: Device: Senhance Assisted Cholecystectomy; Procedure: Laparoscopic Cholecystectomy
Sponsor: Imperial College London
Completed - Condition: Healthy Volunteers
Intervention: Dietary Supplement: SPM Active
Sponsors: Queen Mary University of London; Metagenics, Inc.
Active, not recruiting - Conditions: Meniscus Injury; Osteoarthritis, Knee; Footwear
Interventions: Device: Footwear; Procedure: Gait analysis
Sponsor: University of Salford
Recruiting - Condition: Mood and Cognitive Performance
Intervention: Dietary Supplement: Acute effect of two Saudi cultivars of date fruit on mood and cognitive performance
Sponsor: Newcastle University
Completed - Conditions: Insulin Resistance; Diabetes Mellitus, Type 2; Inflammation; Gastrointestinal Microbiome
Intervention: Behavioral: Controlled diet and exercise.
Sponsors: University of Bath; Teagasc Food Research Centre
Recruiting - Condition: Healthy, Peripheral Neuropathic Pain
Interventions: Drug: TRK-750; Drug: Placebo
Sponsor: Toray Industries, Inc
Recruiting - Condition: Adrenal Insufficiency
Interventions: Drug: Chronocort®; Drug: Cortef®
Sponsors: Diurnal Limited; Simbec Research; Brush Clinical Research Ltd.; Voet Consulting; EMAS Pharma; Medical Matters International Ltd.
Completed - Condition: Autism Spectrum Disorder
Interventions: Other: Social Story; Other: Standard Information
Sponsor: University of Sheffield
Recruiting - Conditions: Obesity; Diabetes
Interventions: Dietary Supplement: Milk Mineral Supplement; Dietary Supplement: Whey Protein Hydrolysate
Sponsor: University of Bath
Completed - Conditions: Obesity; Diabetes
Interventions: Dietary Supplement: Control; Dietary Supplement: Milk mineral supplement
Sponsor: University of Bath
Completed - Conditions: Insulin Resistance; Type2 Diabetes Mellitus; Non-Alcoholic Fatty Liver Disease; Obesity
Intervention: Dietary Supplement: High-fat diet
Sponsors: Loughborough University; Nottingham Trent University; Nottingham University Hospitals NHS Trust
Recruiting - Condition: Healthy Volunteers
Interventions: Drug: XPF-008; Drug: Microcrystalline Cellulose
Sponsor: Xenon Pharmaceuticals Inc.
Recruiting - Condition: Stroke
Intervention: Other: Online Mindfulness Course
Sponsors: University of Surrey; First Community Health and Care; Surrey and Borders Partnership NHS Foundation Trust
Active, not recruiting - Condition: Invasive Aspergillosis
Intervention: Drug: F901318
Sponsors: F2G Ltd.; Covance
Completed - Condition: Viral Upper Respiratory Tract Infection
Interventions: Drug: PrEP-001; Other: Placebo
Sponsors: Prep Biopharm Limited; Hvivo
Completed - Conditions: Aortic Stenosis; Transthyretin Amyloidosis
Intervention:
Sponsor: University of Edinburgh
Recruiting - Conditions: Cataract Extraction; Phacoemulsification; Glistenings; Intraocular Lens Implant; Hydrophobic Acrylic; Cataract Surgery; Light Scatter; Patient Satisfaction; Patient Related Outcome Measures
Intervention: Device: Cataract surgery
Sponsors: Guy's and St Thomas' NHS Foundation Trust; City, University of London; King's College London
Recruiting - Condition: AAA - Abdominal Aortic Aneurysm
Intervention: Other: No Intervention Given
Sponsor: University of Leicester
Not yet recruiting - Condition: Healthy
Interventions: Biological: Ad26.RSV.preF; Drug: Placebo
Sponsor: Janssen Vaccines & Prevention B.V.
Active, not recruiting - Condition: Healthy
Interventions: Drug: CORT125281, 40mg, fasted; Drug: Prednisone 25mg, fasted; Drug: Placebo oral capsule, fasted; Drug: Pioglitazone 15mg Tablet; Drug: Placebo oral capsule, fed; Drug: Prednisone 25mg, fed; Drug: CORT125281, 120mg, fasted; Drug: CORT125281, 360mg, fasted; Drug: CORT125281, 720mg, fasted; Drug: CORT125281, 360mg, fed; Drug: CORT125281, 360mg; Drug: CORT125281, 120mg; Drug: CORT125281, 180mg; Drug: CORT125281, 240mg; Drug: Placebo oral capsule
Sponsor: Corcept Therapeutics
Completed - Conditions: Meniscus Injury; Meniscectomy; Osteoarthritis, Knee
Interventions: Procedure: Meniscectomy; Other: Helathy control comparison
Sponsor: University of Salford
Recruiting - Condition: Ankle Fracture - Medial Malleolus
Interventions: Procedure: Fixation; Procedure: Non-fixation
Sponsor: Royal Infirmary of Edinburgh
Recruiting - Conditions: Asthma; Heart Failure; Pneumonia; Motor Neuron Disease; Vocal Cord Dysfunction; Breathlessness
Intervention:
Sponsors: Cambridge Respiratory Innovations Limited; Innovate UK
Completed - Conditions: Cognitive Performance; Glucose, Low Blood; Glucose, High Blood; Mood
Interventions: Dietary Supplement: Low Glycaemic Diet; Dietary Supplement: High Glycaemic Diet
Sponsor: Matthew Grout
Completed - Conditions: Weight Management; Diabetes Mellitus, Type 2
Interventions: Behavioral: Small Talk Big Difference Immediate access training; Behavioral: Small Talk Big Difference delayed access training
Sponsors: NHS Greater Glasgow and Clyde; University of Glasgow
Recruiting - Condition: Smoking, Tobacco
Interventions: Device: Electron Cigarette; Device: Nicotine Replacement Patch
Sponsor: NHS Greater Glasgow and Clyde
Completed - Conditions: High-intensity Interval Exercise; Heart Rate; Rating of Perceived Exertion; Blood Pressure; Acute Mood; Physical Activity Enjoyment
Interventions: Behavioral: Boxing; Behavioral: Stair stepping; Behavioral: Stair climbing
Sponsor: Teesside University
Completed - Condition: Healthy
Interventions: Drug: LY3305677; Drug: Placebo
Sponsor: Eli Lilly and Company
Completed - Condition: Myocardial Infarction
Intervention: Device: Vitalscan
Sponsor: Creavo Medical Technologies Ltd
Active, not recruiting - Conditions: COPD; Asthma
Interventions: Procedure: Case finding Clinic; Procedure: At Risk Case Clinics; Other: Usual Care
Sponsors: University of Southampton; National Institute for Health Research, United Kingdom; University Hospital Southampton NHS Foundation Trust; University of Birmingham
Recruiting - Condition: Overweight and Obesity
Intervention: Behavioral: Exercise
Sponsor: University of Glasgow
Recruiting - Conditions: Sarcoidosis; Sarcoidosis, Pulmonary; ILD; Interstitial Lung Disease
Intervention: Diagnostic Test: Exercise
Sponsor: Kingston University
Completed - Condition: Cardiorespiratory Fitness
Intervention: Behavioral: HIIT
Sponsor: University of Nottingham
Recruiting - Conditions: Cholestasis; Primary Sclerosing Cholangitis; Primary Biliary Cirrhosis
Interventions: Other: Questionnaire, semen sample, fasting blood sample; Other: Questionnaire; Other: Questionnaire, fasting blood sample
Sponsors: Guy's and St Thomas' NHS Foundation Trust; King's College Hospital NHS Trust
Recruiting - Conditions: Obesity; Childhood Obesity
Intervention: Behavioral: HENRY
Sponsors: University of Leeds; NatCen Social Research
Recruiting - Condition: Healthy
Interventions: Drug: CORT118335, 25 mg; Drug: Prednisone Oral Tablet; Drug: Glucose; Drug: Placebo oral suspension; Drug: CORT118335, 75mg; Drug: CORT118335, 225mg; Drug: CORT118335, 675mg; Drug: CORT118335, 600mg; Drug: CORT118335, 630mg; Drug: CORT118335, 375mg; Drug: CORT118335, 100mg; Drug: CORT118335, 300mg; Drug: CORT118335, 900mg; Drug: CORT118335, 150mg; Drug: CORT118335, 1500mg; Drug: Placebo oral capsule; Drug: CORT118335, dose to be determined
Sponsor: Corcept Therapeutics
Recruiting - Condition: Dental Caries
Intervention: Other: Referred to a specific hospital for treatment
Sponsors: King's College London; King Saud University
Recruiting - Condition: High Altitude Cerebral Edema
Interventions: Drug: Dexamethasone; Drug: Placebo
Sponsor: University Hospitals Coventry and Warwickshire NHS Trust
Not yet recruiting - Condition: Chronic Heart Failure
Intervention: Device: Blood flow restriction
Sponsor: University of Leeds
Recruiting - Condition: Adrenal Insufficiency
Interventions: Drug: Infacort®; Drug: Cortef®
Sponsors: Diurnal Limited; Simbec Research; Brush Clinical Research Ltd.; Voet Consulting; EMAS Pharma; Medical Matters International Ltd.; Nichol Pharma Services Ltd.
Completed - Condition: Acute Lung Injury
Interventions: Drug: Imatinib; Drug: Placebo oral capsule
Sponsors: Exvastat Ltd.; Parexel
Completed - Conditions: Healthy Obesity, Metabolically; Appetite Regulation
Interventions: Dietary Supplement: Inulin-Propionate Esters; Dietary Supplement: Inulin
Sponsors: Imperial College London; University of Glasgow
Recruiting - Conditions: Lung Diseases; Pulmonary Disease; Cystic Fibrosis; Cystic Fibrosis Lung; Cystic Fibrosis Pulmonary Exacerbation; Cystic Fibrosis With Exacerbation; Respiratory Tract Disease; Pulmonary Inflammation; Multi-antibiotic Resistance; Antibiotic Resistant Infection; Lung Infection; Lung Infection Pseudomonal; Lung; Infection, Atypical Mycobacterium; Burkholderia Infections; Burkholderia Cepacia Infection; Lung Inflammation
Interventions: Drug: Inhaled SNSP113; Drug: Inhaled Placebo
Sponsor: Synspira, Inc.
Terminated - Condition: Pulmonary Disease, Chronic Obstructive
Interventions: Drug: [14C]-GSK2269557 IV infusion; Drug: GSK2269557 via DPI; Drug: [14C]-GSK2269557 oral solution
Sponsor: GlaxoSmithKline
Completed - Conditions: Lung Inflammation; Sarcoidosis
Interventions: Radiation: PET/CT scan; Other: LPS Challenge; Other: Saline Challenge; Diagnostic Test: Blood and urine sampling
Sponsors: Cambridge University Hospitals NHS Foundation Trust; GlaxoSmithKline
Recruiting - Conditions: Cognitive Impairment; Dementia; Affective Disorders
Intervention:
Sponsors: University of Oxford; University College, London
Completed - Condition: Stuttering, Developmental
Interventions: Behavioral: Metronome-timed speech; Device: Active tDCS; Device: Sham tDCS
Sponsor: University of Oxford
Recruiting - Condition: Arthritis, Rheumatoid
Interventions: Biological: Cantharidin; Biological: Lipopolysaccharide; Biological: Granulocyte-Macrophage Colony-Stimulating Factor; Drug: Saline Solution
Sponsor: GlaxoSmithKline
Completed - Condition: Autoimmune Diseases
Interventions: Drug: GSK2982772 capsule; Drug: Placebo capsule
Sponsor: GlaxoSmithKline
Recruiting - Conditions: Inappropriate Sinus Tachycardia; Pregnancy Related
Interventions: Diagnostic Test: ECG; Diagnostic Test: heart rate monitor; Diagnostic Test: Autonomic Nervous System (ANS) Activity; Diagnostic Test: Haemodynamic variables; Other: Echocardiogram
Sponsor: Cambridge University Hospitals NHS Foundation Trust
Active, not recruiting - Conditions: SVT; Vagal Bradycardia
Interventions: Device: Supine VM VAD; Device: Supine VAD manometer; Other: Modified VM VAD; Other: Modified VM Manonmeter
Sponsors: University of Exeter; Royal Devon and Exeter NHS Foundation Trust
Completed - Conditions: Cystic Fibrosis; Primary Ciliary Dyskinesia; Bronchiectasis; Asthma; Bronchitis; Sleep Disorder
Intervention: Device: Multiple breath washout testing
Sponsor: Imperial College London
Recruiting - Conditions: Constipation; Diet Modification
Interventions: Diagnostic Test: MRI Scan; Other: Kiwifruit; Other: calorie-matched sugar drink
Sponsors: University of Nottingham; Zespri International Limited
Active, not recruiting - Condition: Impaired Mitochondrial Function, Muscle Performance
Interventions: Dietary Supplement: Acipimox; Dietary Supplement: Placebo
Sponsors: University of Exeter; Royal Devon and Exeter NHS Foundation Trust
Recruiting - Condition: Smoking Cessation
Intervention: Drug: Cytisine
Sponsor: Achieve Life Sciences
Recruiting - Condition: Healthy Volunteers
Interventions: Drug: MB02; Drug: US licenced Avastin®; Drug: EU approved Avastin®
Sponsor: mAbxience S.A
Recruiting - Conditions: Lipid Metabolism; Diabetes
Interventions: Dietary Supplement: Placebo; Dietary Supplement: Tea beverage; Dietary Supplement: Tea extract (medium concentration); Dietary Supplement: Tea extract (high concentration); Dietary Supplement: High fat liquid meal challenge
Sponsors: University of Bath; Lucozade Ribena Suntory
Active, not recruiting - Condition: Healthy
Interventions: Dietary Supplement: Hypotonic; Dietary Supplement: Isotonic; Dietary Supplement: Placebo; Other: Dehydrated
Sponsor: University of Exeter
Completed - Condition: Cognitive Function
Intervention: Other: Exposure is maternal iodine
Sponsor: University Hospital Southampton NHS Foundation Trust
Completed - Condition: Healthy Volunteers
Interventions: Drug: GDC-0853; Drug: Rabeprazole
Sponsor: Genentech, Inc.
Completed - Condition: Appetitive Behavior
Intervention: Behavioral: Dietary energy restriction
Sponsor: University of Leeds
Completed - Condition: Brain Injuries
Interventions: Behavioral: Neurofeedback training; Behavioral: Video game
Sponsors: University of Glasgow; Brain Injury Rehabilitation Trust
Recruiting - Condition: Cough
Interventions: Drug: BAY1817080; Drug: Matching Placebo
Sponsor: Bayer
Recruiting - Conditions: Cachexia; Cancer; Diet Modification; Physical Activity; Advanced Cancer
Interventions: Dietary Supplement: ProSure; Behavioral: Physical Exercise
Sponsors: University of Edinburgh; Marie Curie; ACCORD; NHS Lothian
Recruiting - Condition: Hearing Loss
Interventions: Device: Hearing aid; Device: Mobile phone; Device: Sensor
Sponsor: University College, London
Recruiting - Conditions: Sarcopenia; Muscle Atrophy
Interventions: Dietary Supplement: Whey Protein; Dietary Supplement: Placebo; Other: Resistance Exercise
Sponsors: Coventry University; University Hospitals Coventry and Warwickshire NHS Trust
Recruiting - Condition: Sarcopenia
Intervention: Diagnostic Test: DEXA scan
Sponsor: University of Bedfordshire
Recruiting - Condition: Healthy Volunteers
Intervention: Drug: Tenofovir exalidex (TXL)
Sponsor: ContraVir Pharmaceuticals, Inc.
Completed - Conditions: Obesity; Weight Loss
Interventions: Other: Big Breakfast; Other: Big Dinner
Sponsors: University of Aberdeen; University of Surrey; Centre intégré de l'obésité du CHU de Toulouse (Center of Integrated Obesity); Maastricht University (Nutrim)
Recruiting - Conditions: Interstitial Lung Disease; Idiopathic Pulmonary Fibrosis; Connective Tissue Related ILD; Chronic Hypersensitivity Pneumonitis; Fibrotic Lung Disease
Interventions: Behavioral: Focus groups; Behavioral: Semi-structured interviews
Sponsors: Kingston University; St. George's Hospital, London; University College London Hospitals
Recruiting - Condition: Human Volunteers
Intervention: Biological: MVA-NP+M1
Sponsors: Vaccitech Limited; University of Oxford
Completed - Condition: Neuroendocrine Tumors
Intervention: Other: ongoing fasted state, intake of caffeine containing beverages or 5-item English breakfast
Sponsor: University Hospitals Coventry and Warwickshire NHS Trust
Active, not recruiting - Conditions: Ventral Hernia; Abdominal Wall Defect
Intervention: Procedure: Abdominal Wall Closure Force (N).
Sponsors: University College, London; University College London Hospitals
Enrolling by invitation - Condition: Smoking Cessation
Intervention: Drug: Cytisine
Sponsor: Achieve Life Sciences
Completed - Conditions: Chylothorax; Esophageal Cancer; Thoracic Duct Intra-Operative Injury
Intervention: Drug: Indocyanine Green
Sponsor: Oxford University Hospitals NHS Trust
Recruiting - Conditions: Lipids; Lipid Metabolism; Healthy
Interventions: Other: High SFA diet (Diet 1); Other: Low SFA diet (Diet 2)
Sponsors: University of Surrey; University of Reading; Imperial College London
Recruiting - Condition: Healthy Diet
Intervention: Behavioral: Availability of healthier vs. less healthy foods
Sponsors: University of Cambridge; Oxford University Hospitals NHS Foundations Trust
Completed - Condition: Autoimmune Diseases
Interventions: Drug: GSK2982772 Modified Release (MR); Drug: GSK2982772 Immediate Release (IR)
Sponsors: GlaxoSmithKline; Quotient Clinical
Recruiting - Condition: Depression
Intervention: Behavioral: Google Hangout (VC) group
Sponsors: Queen's University, Belfast; AWARE NI; Northern Ireland Public Health Research Network
Completed - Condition: Genitourinary Syndrome of Menopause
Interventions: Device: Photothermal Non-ablative Erbium:YAG-laser; Device: Fractional Microablative CO2-laser
Sponsor: King's College Hospital NHS Trust
Recruiting - Conditions: Hyperglycemia, Postprandial; Healthy
Interventions: Dietary Supplement: Enriched pomegranate juice; Dietary Supplement: Placebo beverage
Sponsor: University of Leeds
Recruiting - Condition: Heart Failure
Interventions: Drug: Placebo; Drug: BMS-986224
Sponsor: Bristol-Myers Squibb
Recruiting - Conditions: Pregnancy Related; Vaccination
Intervention: Biological: Vaccination with a pertussis containing vaccine
Sponsors: St George's, University of London; Innovative Medicine Initiative; Max Planck Institute for Infection Biology
Recruiting - Conditions: Physical Activity; Sedentary Lifestyle
Intervention: Other: Multicomponent physical activity intervention
Sponsors: Edge Hill University; West Lancashire Sport Partnership; West Lancashire Leisure Trust
Enrolling by invitation - Condition: Influenza, Human
Intervention: Other: Enhanced vaccine safety surveillance
Sponsors: GlaxoSmithKline; University of Surrey
Completed - Condition: Healthy
Intervention: Drug: Tiotropium
Sponsors: 3M; Simbec Research
Completed - Condition: Burns
Interventions: Other: Lactulose and Mannitol solution; Other: Sucralose
Sponsor: GlaxoSmithKline
Completed - Condition: Pancreatitis, Acute Necrotizing
Interventions: Drug: GSK3335065; Drug: Placebo
Sponsor: GlaxoSmithKline
Terminated - Condition: Hamstring Injury
Intervention: Other: Lumbar Mobilisations
Sponsor: Teesside University
Completed - Condition: Respiratory Syncytial Virus Infections
Interventions: Drug: RV521; Drug: Placebo
Sponsor: ReViral Ltd
Completed - Condition: Healthy
Interventions: Drug: ODM-203 (Period 1); Drug: ODM-203 (Period 2); Drug: ODM-203 (Periods 3-6)
Sponsors: Orion Corporation, Orion Pharma; Quotient Clinical
Completed - Condition: Vitamin D Deficiency
Interventions: Radiation: DEXA; Radiation: pQCT; Other: Lifestyle Questionnaire; Other: Aerobic Fitness; Other: Muscular Strength; Biological: Blood draw and finger prick test; Other: Muscular Power
Sponsor: University of Surrey
Active, not recruiting - Condition: Atopic Eczema
Intervention: Device: Domestic ion-exchange water softener
Sponsors: King's College London; Guy's and St Thomas' NHS Foundation Trust; University of Nottingham; University of Sheffield; Imperial College London; University of Amsterdam; University of Dundee
Recruiting - Condition: Language Development
Interventions: Behavioral: Story Starters Intervention; Behavioral: Wait-list Control
Sponsor: Julian Pine
Enrolling by invitation - Condition: Pulmonary Disease, Chronic Obstructive
Interventions: Drug: CCI15106; Drug: Placebo
Sponsor: GlaxoSmithKline
Completed - Condition: Condylar Process of Mandible Open Fracture
Intervention: Procedure: Open Reduction and Internal Fixation
Sponsor: Oxford University Hospitals NHS Trust
Recruiting - Condition: Amyotrophic Lateral Sclerosis
Interventions: Drug: Reference capsule GDC-0134; Drug: Prototype capsule GDC-0134; Drug: rabeprazole
Sponsors: Genentech, Inc.; Quotient Clinical
Completed - Condition: Autism Spectrum Disorder
Intervention: Device: Transcranial direct current stimulation (tDCS)
Sponsors: NHS Greater Glasgow and Clyde; University of Glasgow
Recruiting - Conditions: Constipation; Diet Modification
Interventions: Dietary Supplement: Bran; Dietary Supplement: Nopal; Dietary Supplement: Psyllium
Sponsor: University of Nottingham
Recruiting - Condition: Cancer
Intervention: Other: Hypoxia marker
Sponsor: Institute of Cancer Research, United Kingdom
Recruiting - Conditions: Congenital Disorder; Heart Diseases
Intervention: Other: Exercise Programme
Sponsor: Golden Jubilee National Hospital
Recruiting - Conditions: Stress; Anxiety
Interventions: Dietary Supplement: Minerals + Vitamins; Dietary Supplement: Botanical A; Dietary Supplement: Botanical B; Other: Placebo
Sponsor: University of Leeds
Recruiting - Condition: Anaemia
Interventions: Drug: [14C]-GSK1278863 solution for IV infusion; Drug: [14C]-GSK1278863 oral solution; Drug: Daprodustat 6 mg oral tablet
Sponsor: GlaxoSmithKline
Completed - Conditions: Healthy Volunteers; Osteoarthritis
Interventions: Drug: LEVI-04; Drug: Placebo
Sponsors: Levicept; Hammersmith Medicines Research
Recruiting - Condition: Major Trauma
Intervention: Other: Qualitative interviews and questionnaire survey
Sponsor: Kingston University
Completed - Condition: Infection, Human Immunodeficiency Virus
Interventions: Drug: GSK3640254; Drug: Placebo
Sponsors: ViiV Healthcare; GlaxoSmithKline
Completed - Condition: Exercise-induced Inflammation
Interventions: Dietary Supplement: Fish Oil; Dietary Supplement: Placebo
Sponsor: Loughborough University
Completed - Condition: Respiratory Syncytial Virus (RSV)
Interventions: Drug: PC786 - Single doses; Drug: Placebo - Single doses; Drug: PC786 - Repeat doses; Drug: Placebo - Repeat doses
Sponsor: Pulmocide Ltd
Completed - Condition: Spinal Cord Injuries
Intervention: Procedure: BCI-FES hand therapy
Sponsors: NHS Greater Glasgow and Clyde; University of Glasgow
Recruiting - Condition: Cardiometabolic Risk
Interventions: Other: Low-carbohydrate, high-fat; Other: High-carbohydrate, moderate-fat
Sponsors: Liverpool John Moores University; Liverpool Hope University
Completed - Conditions: Crossing Infections; Drug Resistance, Microbial
Intervention: Other: Exposure
Sponsors: Glasgow Caledonian University; University of Strathclyde; Nick Graves Independent Consultant; NHS Lothian; NHS Lanarkshire
Recruiting - Condition: Healthy
Interventions: Drug: LY3314814; Drug: [13C415N3] LY3314814
Sponsors: Eli Lilly and Company; AstraZeneca
Completed - Condition: Cervical Cancer
Intervention: Other: Self-sampling
Sponsor: Western Health and Social Care Trust
Recruiting - Condition: Healthy
Interventions: Biological: LY3074828; Biological: LY900021
Sponsor: Eli Lilly and Company
Completed - Conditions: Diagnostic Equipment; Oximetry; Pulse Rate
Intervention: Device: Application of prototype sensor to a standard endotracheal tube
Sponsors: City, University of London; Barts & The London NHS Trust
Completed - Conditions: Aphasia; Stroke
Intervention: Behavioral: Adapted Solution Focused Brief Therapy
Sponsor: City, University of London
Recruiting - Condition: Dentin Sensitivity
Interventions: Device: CSSP Toothpaste; Device: Fluoride Toothpaste
Sponsors: Unilever R&D; University of Bristol
Completed - Condition: Hyperglycemia, Postprandial
Interventions: Other: Control; Other: Test
Sponsor: University of Leeds
Completed - Condition: Moderate Pain
Interventions: Drug: 500 mg acetylsalicylic acid (Aspirin, BAYE4465); Drug: 1000 mg acetylsalicylic acid (Aspirin, BAYE4465); Drug: 400 mg ibuprofen(Nurofen); Drug: 400 mg ibuprofen (Dolormin Extra)
Sponsor: Bayer
Completed - Conditions: Constipation - Functional; Irritable Bowel Syndrome Characterized by Constipation
Interventions: Procedure: MRI Motility; Procedure: High Resolution Manometry; Drug: Bisacodyl; Drug: Hyoscine butylbromide
Sponsors: University of Nottingham; University College, London; Queen Mary University of London
Recruiting - Condition: Mitochondrial Diseases
Intervention:
Sponsors: Newcastle University; Newcastle-upon-Tyne Hospitals NHS Trust
Recruiting - Conditions: Obesity; Diabetes
Interventions: Dietary Supplement: Calcium Citrate; Dietary Supplement: Milk Mineral Supplement; Dietary Supplement: Whey Protein Hydrolysate
Sponsor: University of Bath
Completed - Condition: Healthy
Interventions: Dietary Supplement: Red cherry tomato; Dietary Supplement: Yellow cherry tomato
Sponsor: Northumbria University
Completed - Condition: Malaria
Interventions: Biological: ChAdOx1 LS2; Biological: MVA LS2
Sponsor: University of Oxford
Completed - Condition: Healthy
Intervention: Diagnostic Test: MRI and concomitant perfused manometry of bowel motility
Sponsors: University of Nottingham; Food and Drug Administration U.S. Award #HHSF223201510157C; University of Michigan
Active, not recruiting - Conditions: Retention; Compliance; Orthodontic; Periodontal Health
Intervention: Other: Electronic reminder
Sponsor: Queen Mary University of London
Recruiting - Condition: Obesity
Intervention: Behavioral: Lifestyle intervention
Sponsor: University College, London
Recruiting - Conditions: Food Sensory Perception; Selenium Status
Interventions: Dietary Supplement: selenium enriched parsnips; Dietary Supplement: Conventional parsnips
Sponsors: Newcastle University; Fera Science; Institute For Agri-food Research and Innovation
Recruiting - Condition: Type2 Diabetes
Intervention: Dietary Supplement: Orange juice
Sponsors: University Hospitals Coventry and Warwickshire NHS Trust; University of Warwick
Recruiting - Condition: Hereditary Angioedema
Intervention: Drug: BCX7353
Sponsor: BioCryst Pharmaceuticals
Completed - Condition: Pulmonary Disease, Chronic Obstructive
Interventions: Drug: GSK2269557 500 µg; Drug: GSK2269557 750 µg
Sponsor: GlaxoSmithKline
Completed - Condition: Biological Aging
Interventions: Other: Catechin Cohort 1; Other: Curcuminoid Cohort 2; Other: Flavonoid Cohort 3
Sponsor: Abbott Nutrition
Recruiting - Condition: Hyperlipidemia
Interventions: Dietary Supplement: Delphinidin type anthocyanins; Dietary Supplement: Cyanidin type anthocyanins; Dietary Supplement: Placebo
Sponsor: Quadram Institute
Active, not recruiting - Condition: Drug Reactions
Interventions: Drug: Lu AF35700; Drug: Midazolam; Drug: Cocktail of CYP450 substrates
Sponsor: H. Lundbeck A/S
Completed - Condition: Dementia
Intervention: Other: Improving Wellbeing and Health for People with Dementia (WHELD) e-learning training programme
Sponsor: King's College London
Completed - Conditions: Cardiovascular Diseases; Inflammation; Inflammation; Skin; Inflammatory Response; Nitric Oxide
Interventions: Dietary Supplement: Nitrate-rich Beetroot Juice; Dietary Supplement: Nitrate-deplete Beetroot Juice
Sponsor: Queen Mary University of London
Recruiting - Condition: Bacterial Vaginosis
Interventions: Other: Metronidazole; Other: Control: no treatment
Sponsors: Danisco; Community Pharmacology Services Ltd
Completed - Condition: Influenza A
Intervention: Biological: Influenza A/California/04/09
Sponsors: Duke University; United States Department of Defense; Imperial College of London
Enrolling by invitation - Conditions: Visible Difference; Acceptance and Commitment Therapy; ACT; Skin Condition; Hair Condition; Craniofacial; Burns
Intervention: Behavioral: Acceptance-based self-help intervention
Sponsor: University of Sheffield
Completed - Condition: Extracellular Vesicles; Generation and Function
Interventions: Dietary Supplement: Fish oil capsules; Dietary Supplement: High-oleic safflower oil capsules
Sponsors: University of Reading; Biotechnology and Biological Sciences Research Council
Recruiting - Conditions: Childbirth Problems; Labor Complication
Interventions: Device: Cook cervical balloon; Drug: Prostin E2 Vaginal Suppository
Sponsors: St George's, University of London; City, University of London
Recruiting - Condition: Adrenal Insufficiency
Intervention: Drug: Infacort
Sponsors: Diurnal Limited; Simbec Research; EMAS Pharma; Voet Consulting; Brush Clinical Research Ltd.; Medical Matters International Ltd.
Completed - Conditions: Impulsive Behavior; Empathy
Intervention: Device: repetitive transcranial magnetic stimulation
Sponsor: University of Nottingham
Completed - Conditions: Down Syndrome; Patau Syndrome; Edward's Syndrome
Intervention: Procedure: Blood sample
Sponsor: Premaitha Health
Recruiting - Condition: HIV
Interventions: Drug: Descovy® (TAF/FTC); Drug: Viread® (TDF); Drug: Rifadin® (Rifampicin)
Sponsor: St. Stephens Clinical Research
Completed - Conditions: Muscle Atrophy; Weightlessness; Sleep Disturbance; Astronaut-Bone Demineralisation Syndrome
Intervention: Other: HBF Bed Rest
Sponsors: King's College London; Guy's and St Thomas' NHS Foundation Trust
Completed - Conditions: Subjective Cognitive Complaints; Mindfulness
Interventions: Other: Mindfulness-based intervention; Other: Age Well psycho-education
Sponsors: Chelsea and Westminster NHS Foundation Trust; University of Westminster; Imperial College London
Completed - Condition: Chronic Obstructive Pulmonary Disease - COPD
Interventions: Drug: AZD8871; Drug: Placebo
Sponsors: AstraZeneca; Parexel; Industrias Farmacéuticas Almirall S.A.; The Doctors Laboratory; Covance
Completed - Condition: Healthy
Intervention: Drug: tiotropium pMDI
Sponsor: 3M
Completed - Condition: Postprandial Period
Interventions: Dietary Supplement: Blackcurrant extract (low dose); Dietary Supplement: Placebo; Dietary Supplement: Citrus extract (low dose); Dietary Supplement: Blackcurrant extract (high dose); Dietary Supplement: Blackcurrant and citrus extracts (low dose / low dose)
Sponsors: Lucozade Ribena Suntory; King's College London
Completed - Condition: Healthy
Interventions: Drug: LY3002815; Drug: Placebo
Sponsor: Eli Lilly and Company
Active, not recruiting - Conditions: Food Effect; Healthy
Intervention: Drug: BTD-001
Sponsor: Balance Therapeutics
Completed - Condition: Infection, Human Immunodeficiency Virus
Interventions: Drug: Cabotegravir; Drug: Rifabutin
Sponsors: ViiV Healthcare; GlaxoSmithKline
Completed - Conditions: Neonatal Encephalopathy; Asphyxia Neonatorum; Hypoxic-Ischemic Encephalopathy
Intervention:
Sponsor: Thayyil, Sudhin
Recruiting - Condition: Difficult Intubation
Intervention: Procedure: ultrasound
Sponsor: Northampton General Hospital NHS Trust
Completed - Condition: Type 2 Diabetes Mellitus
Interventions: Drug: 2.5 mg saxagliptin / 5 mg dapagliflozin / 850 mg metformin XR FDC tablet; Drug: 2.5 mg saxagliptin / 5 mg dapagliflozin / 1000 mg metformin XR FDC tablet; Drug: 5 mg dapagliflozin / 850 mg metformin XR FDC; Drug: 5 mg dapagliflozin / 1000 mg metformin XR FDC; Drug: 2.5 mg ONGLYZA® (saxagliptin) tablet; Drug: 5 mg Forxiga® (dapagliflozin) tablet; Drug: 500 mg Glucophage XR®
Sponsor: AstraZeneca
Completed - Condition: COPD
Intervention: Other: capacity of primary phagocytes
Sponsor: Sheffield Teaching Hospitals NHS Foundation Trust
Active, not recruiting - Condition: Bioequivalence
Intervention: Drug: RGB-02 or Neulasta® (pegfilgrastim)
Sponsor: Gedeon Richter Plc.
Completed - Conditions: Physical Activity; Health Behavior
Intervention: Behavioral: Fitbit and Bupa Boost app
Sponsors: University of Exeter; Devon and Cornwall Police; Dorset Police
Completed - Condition: Asthma
Interventions: Drug: AZD9898; Drug: Matching Placebo
Sponsors: AstraZeneca; Parexel
Terminated - Condition: Healthy Participants
Interventions: Drug: AJM347; Drug: Placebo
Sponsor: EA Pharma Co., Ltd.
Completed - Condition: Crohn Disease
Intervention: Dietary Supplement: Solid food-based intervention
Sponsors: NHS Greater Glasgow and Clyde; University of Glasgow
Recruiting - Conditions: Basal Cell Carcinoma; Bowen's Disease
Intervention: Device: Fluorescence and thermal imaging
Sponsor: Paul O'Mahoney
Enrolling by invitation - Conditions: Mild Cognitive Impairment; Alzheimer Disease; Vascular Dementia; Healthy Controls
Interventions: Other: Transcranial doppler ultrasonography; Other: Blood pressure monitoring; Other: Heart rate monitoring; Other: End tidal CO2 monitoring; Other: Addenbrooke's cognitive examination
Sponsor: University of Leicester
Completed - Condition: Healthy
Intervention: Drug: BC-3781
Sponsors: Nabriva Therapeutics AG; Quotient Clinical
Completed - Condition: Newborns
Intervention: Other: Cosmetic Products
Sponsors: Johnson & Johnson Consumer Inc. (J&JCI); University of Sheffield
Active, not recruiting - Conditions: Eating Disorder; Healthy
Interventions: Behavioral: Food specific Inhibitory control training; Behavioral: Implementation intentions; Behavioral: General inhibitory control training
Sponsors: King's College London; University of Exeter
Recruiting - Condition: Prostate Cancer
Interventions: Genetic: Genetic SNP profiling; Other: Prostate cancer screening; Procedure: Prostate biopsy
Sponsor: Institute of Cancer Research, United Kingdom
Recruiting - Condition: Premature Obstetric Labor
Interventions: Drug: Progesterone; Drug: Aminophylline
Sponsors: St Stephens Aids Trust; Action Medical Research
Recruiting - Condition: Healthy Volunteers
Interventions: Drug: REGN3918; Drug: Placebo
Sponsor: Regeneron Pharmaceuticals
Completed - Condition: Healthy Volunteers
Interventions: Drug: ASP7713; Drug: Placebo
Sponsor: Astellas Pharma Europe B.V.
Completed - Condition: Multiple Sclerosis
Interventions: Other: Ischemic Preconditioning; Other: Sham Intervention
Sponsor: Sheffield Teaching Hospitals NHS Foundation Trust
Recruiting - Conditions: Diabetes Mellitus, Type 2; Diabetic Cardiomyopathies
Interventions: Diagnostic Test: Cardiovascular magnetic resonance (CMR) imaging and magnetic resonance spectroscopy; Diagnostic Test: Transthoracic echocardiography; Diagnostic Test: Computed tomography coronary artery calcium scoring; Diagnostic Test: Cardiopulmonary exercise testing
Sponsor: University of Leicester
Recruiting - Conditions: Healthy; Nutrition Poor
Interventions: Dietary Supplement: Placebo; Dietary Supplement: Lutein
Sponsors: Kemin Foods LC; DSM Nutritional Products, Inc.
Recruiting - Conditions: Fat; Liver; NAFLD
Interventions: Other: High-fat, low-carbohydrate; Other: Low-fat, high-carbohydrate
Sponsor: University of Oxford
Recruiting - Condition: Vaccination; Infection
Interventions: Other: Positive Affect Intervention; Other: Neutral Control Intervention; Biological: Northern Hemisphere Influenza Vaccine 2017/18 (Delivered as part of Standard Care)
Sponsors: University of Nottingham; Northumbria University
Completed - Condition: Atopic Eczema
Intervention: Diagnostic Test: Skin Testing for Atopic eczema
Sponsors: Sheffield Teaching Hospitals NHS Foundation Trust; University of Sheffield
Recruiting - Condition: Cardiovascular Risk Factor
Interventions: Other: Coconut oil; Other: Butter; Other: Olive oil
Sponsors: University of Cambridge; British Broadcasting Corporation
Completed - Condition: Visual Acuity
Interventions: Device: Investigational Contact Lens; Device: Marketed Contact Lens
Sponsor: Johnson & Johnson Vision Care, Inc.
Completed - Condition: Ebola Virus Disease
Intervention: Biological: Previously exposed to Ebola vaccine
Sponsors: University of Oxford; University of Glasgow
Enrolling by invitation - Conditions: Monitoring, Physiologic; Vital Signs; Sepsis; Altered Level of Consciousness
Intervention: Device: Bodytrak
Sponsors: Inova Design Solutions Ltd; Chelsea and Westminster NHS Foundation Trust; Innovate UK
Not yet recruiting - Condition: Cytochrome P450 Interaction
Interventions: Drug: Lu AF35700; Drug: Itraconazole (200 mg); Drug: Itraconazole (300 mg)
Sponsor: H. Lundbeck A/S
Recruiting - Conditions: Sarcopenia; Aged; Exercise; Preoperative Care
Intervention: Behavioral: HIIT Device: ergometer
Sponsor: University of Nottingham
Completed - Condition: Molecular Mechanisms of Pharmacological Action
Intervention: Drug: [14C]-BTD-001
Sponsor: Balance Therapeutics
Completed - Condition: Hereditary Angioedema
Interventions: Drug: BCX7353; Drug: Digoxin; Drug: BCX7353 + digoxin; Drug: Rosuvastatin; Drug: rosuvastatin + BCX7353; Drug: Cyclosporine + BCX7353
Sponsor: BioCryst Pharmaceuticals
Completed - Conditions: Drug-Related Side Effects and Adverse Reactions; Cardiovascular System Disease
Interventions: Drug: Albuterol Sulfate; Drug: Nicardipine Hydrochloride; Drug: Dobutamine Hydrochloride; Drug: Phenylephrine Hydrochloride; Drug: Verapamil Hydrochloride; Drug: Phentolamine Mesylate; Drug: Placebo
Sponsors: Cambridge University Hospitals NHS Foundation Trust; University of Cambridge; AstraZeneca
Recruiting - Conditions: Streptococcus Pneumoniae Infection; Streptococcus Pneumoniae, Invasive Disease; Streptococcal Pneumonia
Interventions: Diagnostic Test: Nasopharyngeal swab; Diagnostic Test: blood sampling
Sponsors: University of Oxford; Pfizer
Recruiting - Conditions: Part I (SAD) - Healthy Subjects; Part II (MAD) - Chronic Obstructive Pulmonary Disease; Part III (J-SD) - Healthy Japanese Subjects
Interventions: Drug: MEDI3506; Drug: placebo
Sponsor: MedImmune LLC
Recruiting - Condition: HIV
Interventions: Drug: Tivicay; Drug: Rezolsta
Sponsors: St Stephens Aids Trust; ViiV Healthcare
Completed - Conditions: Obstructive Sleep Apnoea; Primary Open Angle Glaucoma
Intervention: Other: Application of continuous positive airway pressure (CPAP)
Sponsors: Papworth Hospital NHS Foundation Trust; Hinchingbrooke Hospital NHS Trust
Terminated - Conditions: Wrist Fracture; Distal Radius Fracture
Intervention:
Sponsor: University of Leicester
Completed - Condition: Healthy Volunteer Study
Intervention: Drug: AST-008
Sponsor: Exicure, Inc.
Completed - Condition: Depression
Interventions: Dietary Supplement: Wild Blueberry Powder-13g; Dietary Supplement: Placebo
Sponsors: University of Reading; Wild Blueberry Association of North America (WBANA)
Active, not recruiting - Conditions: Parkinson Disease; Accidental Fall
Intervention: Other: Self-management guide for people with Parkinson's who fall and their informal caregivers
Sponsors: University of Southampton; National Institute for Health Research, United Kingdom
Active, not recruiting - Condition: Malaria
Interventions: Biological: ChAd63-METRAP; Biological: MVA ME-TRAP
Sponsor: University of Oxford
Recruiting - Condition: Healthy
Interventions: Drug: JNJ-64179375 0.3 mg/kg; Drug: JNJ-64179375 1.0 mg/kg; Drug: JNJ-64179375 2.5 mg/kg; Other: Placebo; Drug: JNJ-64179375 (Dose to be Determined)
Sponsor: Janssen Research & Development, LLC
Completed - Conditions: Healthy Volunteers; Relative Afferent Pupil Defect; Pupil Anomaly
Interventions: Device: Binocular OCT prototype; Device: Konan RAPDx
Sponsor: University College, London
Completed - Condition: Diabetes Mellitus, Type 2
Intervention: Behavioral: Combined resistance exercise and walking
Sponsors: University of Portsmouth; Portsmouth Hospitals NHS Trust
Not yet recruiting - Condition: Tuberculosis
Interventions: Drug: GSK3036656; Drug: Placebo
Sponsor: GlaxoSmithKline
Completed - Condition: Ulcerative Colitis
Interventions: Drug: TOP1288; Drug: Placebo to TOP1288
Sponsor: Topivert Pharma Ltd
Completed - Conditions: Healthy Volunteers; Asthma
Interventions: Drug: PIN201104; Drug: Placebo
Sponsor: Peptinnovate
Completed - Conditions: NAFLD; Nutrient; Excess
Intervention: Other: Overconsumption of specific dietary nutrient
Sponsor: University of Oxford
Recruiting - Condition: Safety
Interventions: Drug: MOR107; Drug: Placebo; Other: Low sodium diet
Sponsors: Alan Richardson; Quotient Clinical
Terminated - Condition: Healthy Volunteers
Interventions: Drug: Arbaclofen Placarbil SR; Drug: Arbaclofen Placarbil MR Prototype A; Drug: Arbaclofen Placarbil MR Prototype B; Drug: Arbaclofen Placarbil IR
Sponsor: Indivior Inc.
Completed - Condition: Depressive Symptoms
Intervention: Behavioral: eMotion
Sponsors: University of Exeter; University of Glasgow
Completed - Condition: Healthy
Interventions: Biological: Mirikizumab Test; Biological: Mirikizumab Reference
Sponsor: Eli Lilly and Company
Completed - Condition: Diabetes
Intervention: Other: Training or detraining
Sponsors: University of Aberdeen; NHS Grampian
Recruiting - Condition: Cognitive Change
Interventions: Device: Cathodal Transcranial direct current stimulation; Dietary Supplement: L-Tyrosine; Device: Transcranial direct current stimulation (sham); Dietary Supplement: Cellulose (placebo)
Sponsor: Sheffield Hallam University
Completed - Condition: Carer Stress Syndrome
Interventions: Behavioral: ACT Self-Help; Behavioral: ACT Self-Help with Telephone Support
Sponsor: University of Nottingham
Active, not recruiting - Conditions: Obesity; Weight Loss
Interventions: Other: High Fibre; Other: High Protein
Sponsor: University of Aberdeen
Recruiting - Condition: Obesity, Acceptance and Commitment Therapy, Weight Management Service
Interventions: Behavioral: Acceptance and commitment therapy; Behavioral: Treatment as usual (dietetic intervention)
Sponsors: University of Sheffield; Mid Yorkshire Hospitals NHS Trust
Withdrawn - Condition: Safety and Tolerability
Interventions: Drug: DP13; Drug: placebo
Sponsors: Damian Pharma AG; Covance; Foundation for Therapeutic Research, Lausanne; University Hospital Inselspital, Berne
Completed - Condition: Asthma
Interventions: Drug: GSK2292767 50 μg; Drug: GSK2292767 500 μg; Drug: Placebo
Sponsor: GlaxoSmithKline
Completed - Condition: Type 1 Diabetes
Interventions: Device: Accelerometer; Other: Anthropomentry; Procedure: Blood tests; Device: BODPOD; Procedure: MRI (Magnetic Resonance Imaging); Other: Food Diary; Device: CGMS (Continuous Glucose Monitoring System); Other: Questionnaire and Hypo Score; Procedure: Mixed Meal Tolerance Test (MMTT); Procedure: Indirect Calorimetry; Drug: Doubly Labelled Water; Drug: Hepatic Mitochondrial Oxidation breath test
Sponsors: University of Edinburgh; NHS Lothian
Active, not recruiting - Conditions: Sepsis; Septic Shock; Sepsis Syndrome; Severe Sepsis
Intervention: Diagnostic Test: Septic
Sponsors: University of Leicester; The Royal College of Anaesthetists; University Hospitals, Leicester
Recruiting - Condition: Stroke
Intervention: Diagnostic Test: Transcranial Doppler Ultrasound
Sponsor: University of Edinburgh
Completed - Condition: Salmonella Typhi Infection
Intervention: Other: Salmonella Typhi (S. Typhi)
Sponsors: University of Oxford; Bill and Melinda Gates Foundation; Yale University
Active, not recruiting - Condition: Airway Management
Interventions: Device: VBM Intubating Laryngeal Tube; Device: I-Gel
Sponsor: Guy's and St Thomas' NHS Foundation Trust
Recruiting - Condition: Cardiovascular Diseases
Interventions: Other: Eligibility and lifestyle restrictions check.; Other: Medical history, demographic and lifestyle factors; Other: Anthropometric measurements: height, weight, and body fat; Other: Blood pressure and heart rate; Other: Forearm blood flow: Visit 1 (EDNRA); Other: Forearm blood flow: Visit 2 (EDNRA); Other: Blood biochemistry (PNPLA3); Other: Blood EPCR function (PROCR); Other: Blood platelet coagulation and function (PROCR); Other: Blood endothelial permeability (PROCR); Other: Blood leukocyte-endothelium adhesion (PROCR); Other: Baseline Venepuncture (PNPLA3, Visit 1); Other: Deuterium water - Loading dose 1 (PNPLA3, Visit 1); Other: Deuterium water - Loading dose 2 (PNPLA3, Visit 1); Other: Energy-balanced dinner (PNPLA3, Visit 1); Other: Fasting venepuncture (PNPLA3, Visit 2); Other: Deuterium water - Maintenance dose (PNPLA3, Visit 2); Other: Consumption of high carbohydrate meal (PNPLA3, Visit 2); Other: Postprandial Venepuncture (PNPLA3, Visit 2); Other: Venepuncture (PROCR)
Sponsors: Cambridge University Hospitals NHS Foundation Trust; University of Cambridge
Recruiting - Conditions: Bronchomalacia; Asthma; Lung Neoplasms; Lung Diseases, Interstitial; Pulmonary Disease, Chronic Obstructive
Interventions: Other: Lung sound transmission measurement; Other: Lung sound recording
Sponsors: Maximilian Nussbaumer; Cambridge University Hospitals NHS Foundation Trust
Recruiting - Condition: Overweight/Obesity
Interventions: Behavioral: Website and pedometer intervention; Other: Control
Sponsor: University of Bath
Completed - Condition: Microcirculation
Intervention: Other: Measurement of sublingual microcirculatory parameters
Sponsor: University Hospitals, Leicester
Active, not recruiting - Condition: Cognitive Development
Interventions: Other: Executive Function Intervention; Other: Active Control Group
Sponsors: University of Sheffield; University of Nottingham
Active, not recruiting - Conditions: Smoking Cessation; Cardiovascular Diseases; Microcirculation; Macrocirculation
Interventions: Other: Electronic Cigarette and behavioural change support.; Other: Nicotine-Free Electronic Cigarette and behavioural change support.; Other: Nicotine Replacement Therapy and behavioural change support.
Sponsors: Sheffield Hallam University; King's College London; Heart Research U.K.; Help2Change
Recruiting - Condition: Inflammatory Bowel Diseases
Intervention: Behavioral: Gratitude diary
Sponsor: University of Sheffield
Completed - Condition: Milk Intolerance
Interventions: Dietary Supplement: A2 milk 100; Dietary Supplement: A2 milk 150; Dietary Supplement: A2 milk 200; Dietary Supplement: A2 milk 250; Dietary Supplement: A1/A2 milk 100; Dietary Supplement: A1/A2 milk 150; Dietary Supplement: A1/A2 milk 200; Dietary Supplement: A1/A2 milk 250
Sponsor: University of Reading
Active, not recruiting - Condition: Child Development
Intervention:
Sponsor: University of Aberdeen
Completed - Condition: Sleep Problem
Intervention: Procedure: Online CBT for insomnia
Sponsors: King's College London; Goldsmiths, University of London; Queen Mary University of London; University of Oxford
Completed - Conditions: Crohn Disease; Mycobacterium Avium Subspecies Paratuberculosis
Interventions: Biological: ChAdOx2 HAV; Biological: MVA HAV
Sponsor: University of Oxford
Recruiting - Condition: Myocardial Infarction
Intervention:
Sponsor: University Hospital Southampton NHS Foundation Trust
Completed - Condition: Atrophic Acne Scar
Interventions: Device: ELAPR002f; Device: Saline
Sponsor: Elastagen Pty Ltd
Completed - Condition: Metabolism Disorder, Glucose
Interventions: Dietary Supplement: Control; Dietary Supplement: Normal Whey protein; Dietary Supplement: Modified whey protein
Sponsor: University of Aberdeen
Active, not recruiting - Condition: Mental Processes
Interventions: Dietary Supplement: Cocoa-Flavanol Supplements; Dietary Supplement: Control Supplements
Sponsors: University of Reading; Mars, Inc.; Biotechnology and Biological Sciences Research Council
Active, not recruiting - Conditions: Epiretinal Membrane; Retinal Hemorrhage
Intervention: Device: Robot assisted surgery
Sponsor: University of Oxford
Recruiting - Condition: Crohn Disease
Intervention: Other: Test soup meal feeding intervention
Sponsors: University of Nottingham; University College, London
Completed - Condition: Coronary Artery Disease
Intervention:
Sponsors: McGill University Health Center; University Hospital Heidelberg; Groote Schuur Hospital; King's College London; University of Wisconsin, Madison; Jewish General Hospital
Suspended - Conditions: Diabetes; Healthy
Interventions: Drug: Furosemide; Drug: Rosuvastatin; Drug: SNAC; Drug: Semaglutide
Sponsor: Novo Nordisk A/S
Completed - Conditions: Lipid Metabolism; Substrate Metabolism; Exercise
Intervention: Behavioral: Study Protocol
Sponsor: University of Bath
Recruiting - Condition: Health Knowledge, Attitudes, Practice
Intervention: Behavioral: Technology-based nutrition education
Sponsors: Kingston University; St George's, University of London; King's College London
Completed - Conditions: Insulin Sensitivity; Insulin Resistance; Type 2 Diabetes Mellitus
Intervention: Dietary Supplement: Yakult light
Sponsors: Loughborough University; Yakult Honsha Co., LTD
Recruiting - Conditions: Bone Loss, Age Realted; Post Menopausal
Interventions: Other: Flaxseed; Other: Placebo control porridge
Sponsor: University of Reading
Recruiting - Condition: Sarcopenia
Intervention: Dietary Supplement: Essential amino acids
Sponsor: University of Birmingham
Recruiting - Condition: Dupuytren Contracture
Intervention: Device: Thermoplastic Hand Splint
Sponsor: Royal Liverpool and Broadgreen University Hospitals NHS Trust
Active, not recruiting - Condition: Psychological Stress
Intervention: Behavioral: The self-help book: Williams, M. & Penman, D. (2011). Mindfulness: A practical guide to finding peace in a frantic world. London: Piatkus.
Sponsors: Canterbury Christ Church University; Sussex Partnership NHS Foundation Trust; University of Sussex
Active, not recruiting - Condition: Healthy Volunteers
Interventions: Drug: Single Ascending Doses of EB8018; Drug: Single Ascending Doses of placebo; Drug: Multiple Ascending Doses of EB8018; Drug: Multiple Ascending Doses of placebo
Sponsors: Enterome; Quotient Clinical
Completed - Condition: Asthma
Interventions: Biological: Lyophilized mepolizumab; Biological: Liquid mepolizumab; Device: Prefilled autoinjector; Device: Prefilled Safety Syringe
Sponsor: GlaxoSmithKline
Completed - Condition: Prostate Cancer
Intervention: Other: PEARL
Sponsor: Hull and East Yorkshire Hospitals NHS Trust
Completed - Condition: Healthy
Interventions: Dietary Supplement: Supradyn® Energy 3RDA; Dietary Supplement: Placebo
Sponsors: Northumbria University; Bayer
Completed - Condition: Dietary Supplementation During Exercise
Interventions: Dietary Supplement: Placebo; Dietary Supplement: Intervention
Sponsor: University of Aberdeen
Active, not recruiting - Condition: Motivation
Interventions: Behavioral: Group A Reminder; Behavioral: Group B Reminder; Behavioral: Group C Reminder; Behavioral: Group D Reminder; Behavioral: Group E Reminder; Behavioral: Group F Reminder; Behavioral: Group G Reminder; Behavioral: Group H Reminder; Behavioral: Group I Reminder
Sponsors: ThinkWell; University of Oxford; The BMJ; Queen's University, Belfast
Enrolling by invitation - Condition: Postpartum Hemorrhage
Interventions: Drug: IH Oxytocin; Drug: IM Oxytocin; Drug: IV Oxytocin; Device: ROTAHALER
Sponsors: GlaxoSmithKline; InVentiv Clinique; Monash University
Recruiting - Conditions: Food Habits; Food Preferences; Behavior; Health Behavior
Interventions: Behavioral: Taste exposure; Behavioral: Nutritional education
Sponsors: University of Leeds; Purely Nutrition Ltd; Economic and Social Research Council, United Kingdom
Completed - Conditions: Cardiovascular Diseases; Chronic Kidney Disease
Interventions: Drug: Darbepoetin Alfa; Drug: Acetylcholine; Drug: Noradrenaline; Drug: BQ 123
Sponsors: Cambridge University Hospitals NHS Foundation Trust; GlaxoSmithKline
Completed - Conditions: Sleep; Intrusive Memories; Posttraumatic Stress Disorder
Intervention:
Sponsors: University of Oxford; Karolinska Institutet; Medical Research Council Cognition and Brain Sciences Unit
Active, not recruiting - Condition: Healthy
Interventions: Other: Caffeine powder -60; Other: Caffeine powder -30; Other: Caffeine powder 0; Other: Placebo powder -60; Other: Placebo powder -30; Other: Placebo powder 0
Sponsor: University of Exeter
Completed - Condition: Healthy
Interventions: Other: Mycoprotein beverage; Other: Milk protein beverage
Sponsor: University of Exeter
Active, not recruiting - Condition: Dental Implant
Intervention: Procedure: Dental implants
Sponsor: The Campbell Clinic, UK
Recruiting - Condition: Induction of Labor Affected Fetus / Newborn
Interventions: Device: Dilapan-S; Drug: Dinoprostone
Sponsors: Birmingham Women's NHS Foundation Trust; University of Birmingham; Medicem International CR s.r.o.
Recruiting - Condition: Healthy
Interventions: Dietary Supplement: Post exercise protein-polyphenol supplement; Dietary Supplement: Post exercise placebo supplement; Dietary Supplement: Pre bed protein-polyphenol supplement; Dietary Supplement: Pre bed placebo supplement
Sponsor: University of Exeter
Completed - Condition: COPD
Intervention: Other: Pulmonary rehabilitation
Sponsor: University College, London
Active, not recruiting - Condition: Mental Health Impairment
Intervention: Other: Completing the Goals Form
Sponsor: University of Roehampton
Recruiting - Conditions: Heart Failure, Diastolic; Edema Brain; Decompensated Heartfailure
Interventions: Device: Heartfelt-1; Device: Weighing scales; Other: Medical grading of oedema; Other: Baseline assessements; Device: Water displacement method; Device: Callipers measurements; Device: Measuring tape
Sponsors: Heartfelt Technologies; Royal Brompton & Harefield NHS Foundation Trust
Completed - Conditions: Breast Feeding; Body Temperature Changes
Intervention: Device: skin-to-skin facilitating garment
Sponsor: Birmingham City University
Recruiting - Condition: Drug Intolerance
Interventions: Drug: Atorvastatin; Drug: Placebo
Sponsors: University of Dundee; NHS Tayside
Active, not recruiting - Condition: Cardiovascular Disease
Interventions: Dietary Supplement: No Mussels; Dietary Supplement: One mussel portion; Dietary Supplement: Two mussel portions; Dietary Supplement: Three mussel portions
Sponsor: University of Aberdeen
Active, not recruiting - Condition: Muscle Function
Interventions: Behavioral: Exercise Snacking; Dietary Supplement: Yogurt
Sponsor: University of Bath
Completed - Condition: Cartilage Disease
Intervention: Device: BioPoly RS Partial Resurfacing Patella Implant
Sponsor: BioPoly LLC
Recruiting - Condition: Cystic Fibrosis
Interventions: Drug: BI 443651; Drug: Placebo
Sponsor: Boehringer Ingelheim
Completed - Condition: Pain
Interventions: Drug: Paracetamol and caffeine; Drug: Paracetamol; Other: Placebo
Sponsor: GlaxoSmithKline
Terminated - Conditions: Chronic Kidney Disease; Hypertrophy, Left Ventricular; Hypertension
Intervention: Procedure: Nephrectomy
Sponsor: University Hospital Birmingham NHS Foundation Trust
Recruiting - Condition: Adenocarcinoma
Intervention: Procedure: Imaging
Sponsor: Institute of Cancer Research, United Kingdom
Recruiting - Condition: Metabolic Responses to Inactivity
Intervention: Other: Physical inactivity
Sponsor: University of Exeter
Completed - Condition: Charcot-Marie-Tooth Disease, Type IA
Interventions: Behavioral: Falls management plus exercise training; Behavioral: Falls management only
Sponsors: University College London Hospitals; Charcot Marie Tooth United Kingdom; Kingston University
Completed - Condition: Healthy Volunteers
Interventions: Drug: Amphetamine; Drug: TAK -041
Sponsor: Takeda
Completed - Conditions: Community Acquired Pneumonia; Respiration Failure; Pneumonia
Intervention:
Sponsors: Imperial College London; NIHR HPRU in Respiratory Infections
Recruiting - Condition: Non-alcoholic Fatty Liver Disease
Intervention: Device: Breath analysis - electronic signature "Breath-print"
Sponsors: University of Edinburgh; University of Strathclyde; University of Amsterdam
Completed - Conditions: Brugada Syndrome; Sudden Death
Intervention: Drug: Ajmaline
Sponsor: St George's, University of London
Recruiting - Condition: Study is Being Conducted in Healthy Volunteers
Interventions: Drug: Symbicort pMDI with spacer device; Drug: Symbicort pMDI without spacer device
Sponsors: AstraZeneca; Parexel
Completed - Condition: Schizophrenia
Interventions: Drug: Low dose AUT00206 800mg; Drug: High dose AUT00206 2000 mg; Drug: Placebo; Drug: Ketamine; Other: Saline
Sponsors: Autifony Therapeutics Limited; University of Manchester
Completed - Conditions: Mesothelioma; Lung Neoplasms; Surgery; Cystic Fibrosis; Pectus Carinatum; Pectus Excavatum; Empyema, Pleural; Pulmonary Disease, Chronic Obstructive
Intervention: Other: Chest wall motion analysis
Sponsors: Heart of England NHS Trust; University of Birmingham; University of Warwick
Recruiting - Condition: Incentive
Interventions: Other: Group 1 information; Other: Group 2 information; Other: Group 3 information; Other: Group 4 information; Other: Group 5 no information; Other: Group A Reminder; Other: Group B Reminders
Sponsors: ThinkWell; The BMJ; University of Oxford; Queen's University, Belfast
Enrolling by invitation - Condition: Hepatitis B, Chronic
Interventions: Other: Placebo; Drug: RO7020531
Sponsor: Hoffmann-La Roche
Recruiting - Condition: Pain
Interventions: Drug: ABX-1431; Drug: Placebo
Sponsors: Abide Therapeutics; University of Oxford
Completed - Condition: Healthy Volunteers
Interventions: Biological: M834; Biological: US-Sourced Orencia®; Biological: EU-Sourced Orencia®
Sponsors: Momenta Pharmaceuticals, Inc.; Mylan Inc.
Completed - Condition: Hepatocellular Carcinoma
Intervention: Other: Analysis of microRNA expression
Sponsors: University of Aberdeen; Robert Gordon University
Recruiting - Condition: Multiple Sclerosis, Progressive
Interventions: Other: High intensity interval training; Other: Continuous moderate exercise
Sponsors: University of Glasgow; NHS Ayrshire & Arran; AKM Stats
Completed - Condition: Malaria
Intervention: Biological: RH5.1/ ASO1
Sponsor: University of Oxford
Recruiting - Condition: Healthy Subjects
Interventions: Drug: AC-084; Drug: Placebo
Sponsor: Idorsia Pharmaceuticals Ltd.
Terminated - Condition: Prevention of Hyperglycaemia
Interventions: Dietary Supplement: Apple polyphenols; Dietary Supplement: Placebo
Sponsors: King's College London; DIANA Food
Completed - Conditions: Diet Induced Thermogenesis; Obesity Control
Interventions: Dietary Supplement: Control Meal; Dietary Supplement: Berry Treatment; Dietary Supplement: Sea Buckthorn Treatment; Dietary Supplement: Wild Garlic Treatment
Sponsor: University of Aberdeen
Completed - Condition: HIV Infection
Interventions: Drug: P2G12 Dose Cohort 1; Drug: P2G12 Dose Cohort 2; Drug: P2G12 Dose Cohort 3
Sponsor: St George's, University of London
Not yet recruiting - Conditions: Patellofemoral Pain; Anterior Knee Pain
Intervention: Other: PowersTM strap
Sponsor: University of Salford
Completed - Condition: Behaviour
Interventions: Dietary Supplement: Bimuno (BGOS); Other: Maltodextrin
Sponsors: University of Oxford; Clasado Biosciences Ltd
Enrolling by invitation - Condition: Lipidaemia
Interventions: Dietary Supplement: Palm olein; Dietary Supplement: Interesterified palm olein; Dietary Supplement: Soybean oil
Sponsors: Imperial College London; Malaysia Palm Oil Board
Completed - Condition: Lipidemia
Intervention: Behavioral: Meat reduction
Sponsors: University of Nottingham; Biotechnology and Biological Sciences Research Council
Completed - Conditions: Adrenal Insufficiency; Congenital Adrenal Hyperplasia; Cushing Syndrome; Growth Hormone Deficiency; Acromegaly; Primary Hyperaldosteronism
Intervention: Other: 27 hour subcutaneous fluid sampling
Sponsors: Haukeland University Hospital; Karolinska Institutet; University Hospitals Bristol NHS Foundation Trust; Evaggelismos Hospital, Greece
Recruiting - Condition: Invasive Aspergillosis
Interventions: Drug: IV F901318; Drug: Oral F901318
Sponsors: F2G Ltd.; Quotient Clinical
Not yet recruiting - Condition: Bone Health
Intervention: Other: No intervention
Sponsors: Dr Tina Smith; London South Bank University
Completed - Condition: Malaria
Interventions: Biological: R21 with Matrix-M1; Biological: ChAd63 ME-TRAP; Biological: MVA ME-TRAP
Sponsor: University of Oxford
Completed - Condition: Preeclampsia
Intervention: Device: TheraSorb sFlt-1 adsorber
Sponsors: Miltenyi Biotec GmbH; Cromsource
Recruiting - Condition: Functional Neurological Disorders
Intervention: Other: Behavioural study and functional MRI
Sponsor: University College, London
Recruiting - Condition: Dentin Sensitivity
Interventions: Other: Stannous fluoride; Other: Sodium monofluorophosphate
Sponsor: GlaxoSmithKline
Completed - Condition: Increased Overbite
Intervention: Device: Bite turbo
Sponsors: NHS Tayside; University of Dundee
Recruiting - Condition: Pulmonary Disease, Chronic Obstructive
Intervention: Other: Influenza Vaccination
Sponsors: University of Lincoln; University of Kent; NHS Lincolnshire West Clinical Commissioning Group; NHS South Lincolnshire Clinical Commissioning Group
Completed - Conditions: Vaccination; Immunization
Interventions: Biological: Synflorix; Biological: Prevenar13
Sponsors: Public Health England; Imperial College London; Institute of Child Health
Withdrawn - Conditions: Sarcopenia; Muscular Atrophy
Interventions: Dietary Supplement: Protein Supplementation; Other: Aerobic Exercise; Other: Resistance Exercise
Sponsor: Liverpool Hope University
Recruiting - Conditions: Chronic Pain; Pain Measurement; Mastectomy; Postoperative Pain
Intervention: Other: Questionnaire
Sponsor: Royal Infirmary of Edinburgh
Completed - Condition: Orthodontics
Interventions: Procedure: Appointment intervals; Device: fixed orthodontic braces
Sponsor: King's College London
Recruiting - Condition: Neuroblastoma
Interventions: Drug: Nivolumab; Drug: Ch14.18/CHO
Sponsors: University Hospital Southampton NHS Foundation Trust; University College London Hospitals NHS Foundation Trust; University of Wisconsin, Madison; University Hospital Greifswald; Solving Kids' Cancer US/EU; Joining Against Cancer in Kids; The Band of Parents
Recruiting - Condition: Influenza in Humans
Interventions: Drug: AL-794; Drug: Oseltamivir; Drug: Digoxin; Drug: Midazolam; Drug: Pitavastatin; Drug: JNJ-63623872
Sponsor: Alios Biopharma Inc.
Completed - Condition: Depression
Interventions: Behavioral: IBLT; Behavioral: IBLT control
Sponsor: University of Oxford
Recruiting - Condition: Atopic Eczema
Intervention: Radiation: combined ultraviolet phototherapy (NB-UVB + UVA1) vs. NB-UVB monotherapy
Sponsors: University of Dundee; NHS Tayside
Recruiting - Condition: Healthy Volunteers
Interventions: Drug: UCB7858; Drug: Placebo
Sponsor: UCB Biopharma S.P.R.L.
Completed - Conditions: Autism; Attention Deficit Hyperactivity Disorder; Autism Spectrum Disorder
Interventions: Dietary Supplement: a2 milk; Dietary Supplement: a1 containing milk
Sponsors: Northumbria University; ESPA Research; a2 Milk Company Ltd.
Completed - Condition: Malaria
Interventions: Drug: Oral administration of P218 capsules; Drug: Oral administration of P218 matching placebo.
Sponsors: Medicines for Malaria Venture; Richmond Pharmacology Limited
Completed - Conditions: Learning; Quality Improvement; eLearning
Interventions: Other: QI4U learning; Other: Facilitated learning; Other: QI4U and Facilitated learning
Sponsors: Chelsea and Westminster NHS Foundation Trust; National Institute for Health Research, United Kingdom; OCB Media
Recruiting - Conditions: Constipation; Risk Factors
Intervention:
Sponsor: Queen Mary University of London
Completed - Condition: Autoimmune Diseases
Interventions: Radiation: 18F-FDG PET/CT Imaging; Radiation: 11C-MET PET/CT Imaging; Procedure: MRI Imaging with intravenous contrast with gadoterate meglumine; Procedure: Minor Salivary gland (labial) biopsy
Sponsors: GlaxoSmithKline; Quintiles, Inc.
Completed - Condition: Tako-tsubo Cardiomyopathy
Interventions: Procedure: Magnetic resonance imaging; Biological: Acute Inflammatory Activation study; Radiation: PET CT; Behavioral: Psychological assessment
Sponsors: University of Aberdeen; NHS Grampian
Recruiting - Condition: Osteoarthritis
Intervention:
Sponsor: Cambridge University Hospitals NHS Foundation Trust
Recruiting - Conditions: Colonic Neoplasms; Colorectal Neoplasms
Intervention: Other: Training with feedback
Sponsors: London North West Healthcare NHS Trust; University College London Hospitals
Recruiting - Condition: Healthy Volunteer
Interventions: Drug: GDC-0276 capsule; Drug: GDC-0276 tablets
Sponsor: Genentech, Inc.
Withdrawn - A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of JNJ-48816274Condition: Healthy
Interventions: Drug: JNJ-48816274; Drug: Placebo
Sponsor: Janssen-Cilag International NV
Completed - Conditions: Asthma; Pulmonary Disease, Chronic Obstructive
Intervention:
Sponsors: University of Leicester; University Hospitals, Leicester
Recruiting - Condition: Respiratory Syncytial Virus Infections
Interventions: Drug: MEDI8897; Drug: Placebo
Sponsor: MedImmune LLC
Active, not recruiting - Condition: Parkinson's Disease
Intervention:
Sponsor: South Glasgow University Hospitals NHS Trust
Active, not recruiting - Condition: Vascular Diseases
Interventions: Device: electronic cigarette + 16mg nicotine & flavor; Other: electronic cigarette + 0mg nicotine & flavor; Other: Tobacco cigarette
Sponsors: University of Dundee; NHS Tayside; British Heart Foundation
Completed - Condition: Liver Diseases
Interventions: Device: MRI; Device: Transient Elastography
Sponsor: Perspectum Diagnostics Ltd
Completed - Condition: Sepsis
Intervention: Device: Infrared thermal imaging
Sponsors: University Hospitals, Leicester; Association of Anaesthetists of Great Britain and Ireland
Recruiting - Condition: Cirrhosis of the Liver
Interventions: Biological: Faecal microbiota transplantation; Biological: Placebo
Sponsors: King's College London; King's College Hospital NHS Trust
Recruiting - Conditions: Primary Open Angle Glaucoma; Normal Tension Glaucoma; Ocular Hypertension
Intervention:
Sponsor: University of Plymouth
Recruiting - Condition: Alzheimer Disease
Interventions: Radiation: [11C]BU99008; Drug: Idazoxan
Sponsors: Imperial College London; GlaxoSmithKline
Completed - Conditions: Exercised Induced Asthma; Asthma
Interventions: Dietary Supplement: HOST-DM059; Dietary Supplement: Maltodextrin
Sponsors: Nottingham Trent University; University of Reading; Clasado Biosciences; Imperial College London; HOST Therabiomics; The John van Geest Cancer Research Centre
Recruiting - Conditions: Transplantation, Heart-Lung; Chronic Lung Allograft Dysfunction; Bronchiolitis Obliterans Syndrome
Interventions: Other: EIT; Other: Salbutamol nebulisation and with CPAP
Sponsors: Guy's and St Thomas' NHS Foundation Trust; ADIR Association
Completed - Conditions: Dementia; Accidental Falls
Intervention: Other: Tai Chi
Sponsors: Bournemouth University; Southern Health NHS Foundation Trust; Dorset HealthCare University NHS Foundation Trust; Peninsula Clinical Trials Unit; National Institute for Health Research, United Kingdom; University of Southampton; Elemental Tai Chi; Alzheimer's Society; Solent NHS Trust
Active, not recruiting - Condition: Healthy
Interventions: Drug: Odalasvir (ODV); Drug: AL-335; Drug: Placebo
Sponsor: Janssen Research & Development, LLC
Completed - Condition: Language Development
Interventions: Behavioral: Language comprehension intervention; Behavioral: Counting intervention
Sponsors: University of Sheffield; University of Leeds
Completed - Condition: Psoriatic Arthritis
Intervention: Drug: Secukinumab
Sponsors: University of Liverpool; Novartis
Active, not recruiting - Condition: Overweight and Obesity
Interventions: Other: inulin; Other: arabinoxylan
Sponsor: University of Reading
Recruiting - Condition: Chronic Obstructive Pulmonary Disease
Interventions: Drug: CHF6297 (Part 1 - SAD); Drug: Placebo (Part 1 - SAD); Drug: CHF6297 (Part 2 - MAD); Drug: Placebo (Part 2 - MAD); Drug: CHF6297 (Part 3); Drug: Placebo (Part 3); Drug: CHF6297 (Part 4); Drug: Placebo (Part 4)
Sponsor: Chiesi Farmaceutici S.p.A.
Recruiting - Condition: Gut Microbiota
Interventions: Dietary Supplement: Synergy1; Dietary Supplement: Maltodextrin
Sponsor: University of Reading
Completed - Condition: Diabetes Mellitus, Type 2
Intervention: Other: Tinned mackerel fish
Sponsor: University of Aberdeen
Recruiting - Conditions: Gastrectomy; Oesophagectomy; Dumping Syndrome; Hypoglycaemia
Interventions: Drug: Somatostatin; Drug: Rifaximin
Sponsor: Cambridge University Hospitals NHS Foundation Trust
Recruiting - Condition: Gastrointestinal Haemorrhage
Interventions: Device: PuraStat®; Procedure: Electrocautery
Sponsor: Portsmouth Hospitals NHS Trust
Completed - Condition: Osteoporosis
Intervention: Dietary Supplement: selenase (selenium)
Sponsors: Sheffield Teaching Hospitals NHS Foundation Trust; National Institute for Health Research, United Kingdom; University of Sheffield
Active, not recruiting - Condition: Breast Cancer
Intervention:
Sponsors: University of Dundee; NHS Tayside; University of St Andrews
Completed - Condition: Diabetes Mellitus, Type 1
Interventions: Procedure: Inguinal lymph node fine needle aspirate biopsy; Procedure: Inguinal lymph node core biopsy; Procedure: Peripheral blood collection; Other: Pre- and post-biopsy questionnaire
Sponsor: GlaxoSmithKline
Completed - Condition: Transthyretin-mediated Amyloidosis (ATTR Amyloidosis)
Interventions: Drug: ALN-TTRSC02; Drug: Sterile Normal Saline (0.9% NaCl)
Sponsor: Alnylam Pharmaceuticals
Completed - Condition: Retinal Degeneration
Interventions: Other: Questionnaire; Other: Computerised contrast sensitivity function test
Sponsor: University of Oxford
Completed - Condition: Stroke
Intervention:
Sponsor: University Hospitals Coventry and Warwickshire NHS Trust
Recruiting - Condition: Human Papillomavirus Virus
Intervention: Other: venepuncture
Sponsor: Public Health England
Completed - Condition: Meningococcal Disease
Intervention: Other: venepuncture only
Sponsor: Public Health England
Completed - Conditions: Anorexia Nervosa; Compulsive Behavior
Interventions: Drug: N-acetyl cysteine; Drug: Placebo
Sponsor: University of Oxford
Completed - Condition: Impaired Mitochondrial Function, Muscle Performance
Interventions: Dietary Supplement: Acipimox; Dietary Supplement: placebo
Sponsors: Royal Devon and Exeter NHS Foundation Trust; University of Exeter
Recruiting - Condition: Sleep
Intervention: Behavioral: Sleep Lengthening
Sponsor: King's College London
Completed - Condition: Neonatal Neuroimaging
Intervention: Device: 3.0 T Neonatal MRI scanner
Sponsors: GE Healthcare; Wellcome Trust
Completed - Conditions: Inflammation; Aging
Intervention: Other: Maintaining a normal daily living lifestyle
Sponsor: University of Bath
Active, not recruiting - Condition: Denture Cleansers
Interventions: Device: Denture Cleanser Daily Use Period; Device: Denture Cleanser Weekly Use Period; Other: Water
Sponsor: GlaxoSmithKline
Completed - Condition: Language Development
Interventions: Behavioral: Contingent Reading Intervention; Behavioral: Book Provision Control
Sponsor: University of Sheffield
Completed - Condition: Dentin Sensitivity
Interventions: Device: Stannous fluoride; Other: Sodium monofluorophosphate; Other: Mineral water
Sponsor: GlaxoSmithKline
Completed - Condition: Cognitive Function
Interventions: Dietary Supplement: 3 g PronovaPure 150:500 EE EU; Dietary Supplement: 3 g PronovaPure 500:200 EE EU; Dietary Supplement: 3 g Placebo
Sponsors: Northumbria University; Pronova BioPharma
Active, not recruiting - Condition: Endothelial Function and Arterial Stiffness
Interventions: Other: flow mediated dilation (endothelial function); Other: ABPI; Other: Pulse wave velocity and augmentation index; Other: blood pressure; Other: ramp test
Sponsor: St George's, University of London
Recruiting - Condition: Tinnitus
Intervention: Other: Visual Stimulus Condition Set
Sponsors: University of Leicester; Leicester Royal Infirmary NHS Trust
Recruiting - Condition: Malaria, Falciparum
Intervention: Drug: [14C]-GSK3191607
Sponsors: GlaxoSmithKline; Hammersmith Medicines Research
Completed - Condition: Healthy Volunteers
Intervention: Other: Hyperpolarised Xenon
Sponsor: Sheffield Teaching Hospitals NHS Foundation Trust
Recruiting - Condition: Ataxia-Telangiectasia
Interventions: Drug: Metformin; Drug: Pioglitazone
Sponsors: NHS Tayside; University of Dundee
Completed - Condition: Glucose Metabolism Disorders
Interventions: Behavioral: Exercise; Behavioral: Breakfast; Behavioral: Maintain habitual habits
Sponsor: University of Bath
Active, not recruiting - Condition: Tennis Elbow
Interventions: Procedure: Platelet Rich Plasma Injection; Procedure: Open Surgical Release
Sponsor: Royal Devon and Exeter NHS Foundation Trust
Completed - Conditions: Respiratory Syncytial Virus Infections; Influenza, Human
Interventions: Biological: RSV A Memphis 37; Biological: Influenza A/California/04/2009
Sponsors: Imperial College London; Medical Research Council; Wellcome Trust; National Institute for Health Research, United Kingdom
Recruiting - Condition: Perfectionism
Intervention: Other: online guided self-help intervention for perfectionism
Sponsor: Institute of Child Health
Completed - Condition: Healthy
Interventions: Drug: TAK-020 Captisol Oral Solution; Drug: TAK-020 CCT; Drug: TAK-020 SDT; Drug: TAK-020 IRT; Drug: TAK-020 Solid Formulation
Sponsor: Takeda
Completed - Conditions: Ulcerative Colitis; Crohn's Disease
Interventions: Drug: Placebo; Drug: UTTR1147A
Sponsor: Genentech, Inc.
Recruiting - Condition: Dentin Sensitivity
Intervention: Drug: stannous fluoride
Sponsor: GlaxoSmithKline
Completed - Condition: Depressive Disorder, Major
Interventions: Other: MA; Other: DEP
Sponsors: University of Cambridge; University of Oxford; University of Glasgow; University of Sussex; King's College London; Janssen, LP; H. Lundbeck A/S; GlaxoSmithKline
Completed - Condition: Smoking
Intervention:
Sponsor: St George's, University of London
Active, not recruiting - Condition: Healthy
Interventions: Dietary Supplement: 100% Florida OJ; Dietary Supplement: Placebo Equicaloric Orange Drink
Sponsors: University of Leeds; Department of Citrus, State of Florida USA; University of East Anglia
Completed - Condition: Retina; Change
Intervention:
Sponsor: University of Oxford
Completed - Changes in Inflammatory Markers During Pulmonary Rehabilitation Based on Exacerbation States in COPDCondition: Chronic Obstructive Pulmonary Disease
Intervention: Other: Sample collection
Sponsors: University of Lincoln; National Health Service, United Kingdom
Active, not recruiting - Condition: Aspergillosis
Interventions: Drug: PC945 - single doses; Drug: Placebo - single doses; Drug: PC945 - repeat doses; Drug: Placebo - repeat doses
Sponsor: Pulmocide Ltd
Completed - Condition: Dental Caries
Intervention: Other: Impression intervention
Sponsors: Sheffield Teaching Hospitals NHS Foundation Trust; 3M ESPE
Active, not recruiting - Condition: Respiratory Syncytial Virus (RSV) Infection
Interventions: Drug: BTA-C585 oral capsule; Drug: Matching placebo capsules
Sponsor: Biota Pharma Europe Limited
Completed - Condition: Healthy Volunteer
Interventions: Drug: Folic Acid; Drug: GDC-0853; Drug: Methotrexate; Drug: Rabeprazole
Sponsor: Genentech, Inc.
Completed - Condition: Retinitis Pigmentosa
Intervention: Device: Implant 'on' vs implant 'off'
Sponsor: University of Oxford
Completed - Condition: HIV
Interventions: Drug: Microgynon 30®; Drug: Evotaz®
Sponsors: St Stephens Aids Trust; Bristol-Myers Squibb
Terminated - Conditions: Pulmonary Disease, Chronic Obstructive; Pulmonary Emphysema
Intervention:
Sponsor: Boehringer Ingelheim
Active, not recruiting - Condition: Hypertension, Pulmonary
Interventions: Drug: FDC (ambrisentan 10 mg-tadalafil 40 mg) single dose; Drug: Reference (ambrisentan 10 mg + tadalafil 40 mg given concurrently)
Sponsors: GlaxoSmithKline; Covance Harrogate; Hammersmith Medicines Research
Completed - Conditions: Obstructive Sleep Apnoea; Open Angle Glaucoma
Intervention:
Sponsors: Papworth Hospital NHS Foundation Trust; Anglia Ruskin University; Hinchingbrooke Healthcare NHS Trust
Completed - Condition: Postpartum Haemorrhage (PPH)
Intervention: Device: The PPH Butterfly
Sponsors: Andrew Weeks MD MRCOG; National Institute for Health Research, United Kingdom; Liverpool Women's NHS Foundation Trust
Completed - Conditions: Psoriasis; Healthy Subjects
Interventions: Drug: Placebo; Drug: ABY-035 i.v.; Drug: ABY-035 s.c.
Sponsors: Affibody; Covance
Completed - Condition: Primary Hyperoxaluria Type 1 (PH1)
Interventions: Drug: Lumasiran; Drug: Sterile Normal Saline (0.9% NaCl)
Sponsor: Alnylam Pharmaceuticals
Active, not recruiting - Condition: Healthy
Interventions: Other: Treatment; Other: Comparator
Sponsors: Unilever R&D; Bristol Dental School and Hospital
Completed - Conditions: Obesity; Smoking Cessation; Alcoholism
Interventions: Drug: Exenatide; Biological: Desacyl ghrelin; Biological: Saline
Sponsor: Imperial College London
Recruiting - Conditions: DNA Damage; Inflammation
Interventions: Dietary Supplement: White carrots; Dietary Supplement: Oat biscuits
Sponsor: Newcastle University
Completed - Conditions: Erythromelalgia; Pain Insensitivity, Congenital; Hereditary Sensory and Autonomic Neuropathies; Chronic Pain
Intervention: Other: Observation
Sponsors: King's College London; University of Oxford; Neuroscience Technologies S.L.P
Recruiting - Condition: Cognitive Function and Mood
Intervention: Other: Herbal Beverage
Sponsors: PepsiCo Global R&D; Northumbria University
Completed - Condition: Cognitive Function
Intervention: Other: Phenolic Beverage
Sponsors: PepsiCo Global R&D; Northumbria University
Completed - Condition: Nutritional and Metabolic Diseases
Intervention:
Sponsor: Mebo Research, Inc.
Completed - Condition: Breast Cancer
Interventions: Other: MRI; Other: Ultrasound
Sponsors: Institute of Cancer Research, United Kingdom; Cancer Research UK
Completed - Condition: Tooth Erosion
Interventions: Other: RS01; Other: Water
Sponsors: Unilever R&D; Bristol Dental School and Hospital
Completed - Conditions: Arthritis, Juvenile Idiopathic; Enthesitis-Related Arthritis, Juvenile
Interventions: Other: MRI scan (adolescent spine protocol); Other: MRI scan (whole body protocol)
Sponsor: University College London Hospitals
Recruiting - Condition: Childhood Obesity
Interventions: Behavioral: Optimisation + HENRY; Behavioral: HENRY as standard
Sponsor: University of Leeds
Completed - Condition: Healthy Subjects
Interventions: Drug: AZD7986; Drug: Verapamil; Drug: Itraconazole; Drug: Diltiazem
Sponsor: AstraZeneca
Completed - Conditions: Vision Disorders; Reading Disabilities
Interventions: Device: Precision tinted lenses; Device: Non-beneficial tinted lenses
Sponsor: City, University of London
Recruiting - Condition: Coeliac Disease
Intervention: Device: Simtomax
Sponsor: Sheffield Teaching Hospitals NHS Foundation Trust
Completed - Conditions: Diabetic Neuropathy; Neuropathic Pain; Chronic Pain; Carpal Tunnel Syndrome; Peripheral Neuropathies
Intervention: Other: Observation
Sponsors: King's College London; University of Oxford; Imperial College London; Sheffield Teaching Hospital NHS Foundation Trust
Recruiting - Condition: Hepatitis B
Interventions: Drug: GSK3389404; Drug: Matching Placebo
Sponsor: GlaxoSmithKline
Completed - Condition: Depression
Intervention:
Sponsors: University College, London; British Heart Foundation
Active, not recruiting - Condition: Menopausal Flushing
Interventions: Drug: NK3R antagonist - AZD4901; Drug: Placebo
Sponsors: Imperial College London; Medical Research Council; AstraZeneca; National Institute for Health Research, United Kingdom
Completed - Condition: Widespread Chronic Pain
Intervention: Behavioral: Cognitive Behavioural Therapy
Sponsor: University of Aberdeen
Recruiting - Condition: Type 2 Diabetes
Intervention:
Sponsors: Natasha Duke; University of Southampton
Completed - Condition: Human Gut Microbiota
Intervention: Other: Stool sample collection
Sponsor: Quadram Institute
Enrolling by invitation - Condition: Healthy
Intervention: Drug: Tiotropium
Sponsors: 3M; Quotient Clinical
Completed - Conditions: Pelvic Girdle Pain; Symphysis Pubis Dysfunction
Intervention: Device: Customised Dynamic Elastomeric Fabric Orthosis (DEFO)
Sponsor: University of Plymouth
Completed - Condition: Chronic Obstructive Pulmonary Disease (COPD)
Intervention:
Sponsors: Pneumacare Ltd; Cambridge University Hospitals NHS Foundation Trust
Recruiting - Conditions: Vascular Disease; Intermittent Claudication
Intervention: Other: Supervised exercise programme
Sponsor: University of Hull
Completed - Condition: Obesity
Intervention: Dietary Supplement: Cellodextrin
Sponsors: University of Nottingham; Biotechnology and Biological Sciences Research Council
Recruiting - Condition: Accidental Falls
Intervention: Device: Exergame plus usual treatment
Sponsor: University of Manchester
Completed - Condition: Language Development
Interventions: Behavioral: Reading Together - Pausing for Reading; Behavioral: Reading Together - Dialogic Reading; Behavioral: Reading Together - Shared Reading Control
Sponsor: Caroline Rowland
Completed - Condition: Amyloidosis
Intervention: Drug: GSK3039294
Sponsor: GlaxoSmithKline
Terminated - Condition: Sedentary Lifestyle
Intervention: Behavioral: 7 days of habitual physical activity followed by 7 days of reduced physical activity
Sponsors: University of Birmingham; Maastricht University
Completed - Condition: Dental Caries
Intervention: Other: No intervention given
Sponsor: NHS Tayside
Active, not recruiting - Condition: Influenza A
Interventions: Drug: MHAA4549A; Drug: Placebo
Sponsor: Genentech, Inc.
Completed - Condition: Ageing
Intervention: Behavioral: Sedentary time
Sponsors: University of Birmingham; The Dunhill Medical Trust; Glasgow Caledonian University
Recruiting - Condition: HIV
Interventions: Biological: DNA-C CN54ENV; Biological: CN54gp140; Device: Trigrid Delivery System - Intramuscular; Device: Trigrid Delivery System - Intradermal
Sponsors: Imperial College London; Medical Research Council
Completed - Condition: Parkinson's Disease
Intervention:
Sponsors: Newcastle-upon-Tyne Hospitals NHS Trust; Newcastle University
Completed - Condition: Dietary Manipulation
Interventions: Other: Diet with a different macronutrient content A; Other: Diet with a different macronutrient content B; Other: Diet with a different macronutrient content C; Other: Interval treadmill running exercise; Other: Steady state treadmill running exercise
Sponsors: University of Birmingham; Lucozade Ribena Suntory
Completed - Conditions: Osteoarthritis; Pain
Intervention: Procedure: Joint replacement surgery
Sponsor: St George's, University of London
Recruiting - Condition: Tolerance
Interventions: Drug: Metformin; Drug: Omeprazole; Drug: Placebo
Sponsors: NHS Tayside; University of Dundee
Completed - Conditions: Delirium; Dementia
Intervention: Other: No intervention given to participants
Sponsors: University of Edinburgh; Medical Research Council; NHS Lothian; University of Glasgow; NHS Greater Glasgow and Clyde; Cambridge Cognition Ltd
Completed - Condition: Pulmonary Disease
Interventions: Device: Structured Light Plethysmography; Device: Pneumotachograph Spirometry
Sponsors: Pneumacare Ltd; Cambridge University Hospitals NHS Foundation Trust; University of Cambridge
Completed - Condition: Activated PI3K-delta Syndrome
Intervention: Drug: GSK2269557 DPI 500 mcg
Sponsor: GlaxoSmithKline
Recruiting - Condition: Malaria
Interventions: Biological: R21; Biological: Matrix-M1
Sponsor: University of Oxford
Completed - Condition: Schizophrenia, Cerebellar Ataxia
Interventions: Drug: TAK-831 Oral Suspension; Drug: TAK-831 Placebo; Drug: TAK-831 Tablet
Sponsor: Takeda
Terminated - Condition: Weight
Interventions: Other: Non Nutritive Sweetened Beverages; Other: Control
Sponsors: Professor Jason Halford; American Beverage Association
Recruiting - Condition: Diabetes
Interventions: Dietary Supplement: Cambridge Weight Plan; Other: Supervised Exercise Sessions
Sponsors: University of Leicester; University Hospitals, Leicester; National Institute for Health Research, United Kingdom
Recruiting - Condition: Depressive Disorder
Interventions: Drug: TAK-653 Placebo; Drug: TAK-653
Sponsor: Takeda
Completed - Conditions: Surgery; Enhanced Recovery; Technology
Intervention: Device: Activity sensor (3 axis accelerometer)
Sponsor: Imperial College London
Completed - Condition: Insulin Resistance
Interventions: Other: Regular meal pattern; Other: Irregular meal pattern
Sponsor: University of Nottingham
Completed - Condition: Hypertension, Pulmonary
Intervention: Drug: [11C]-GSK2256098 500 MBq
Sponsor: GlaxoSmithKline
Completed - Condition: Lower Limb Amputation
Intervention: Other: Home-based Games Console Balance Training
Sponsors: Nottingham Trent University; Nottingham University Hospitals NHS Trust; University of Hull; Bournemouth University; Jonkoping University
Suspended - Conditions: Celiac Disease; Coeliac Disease; Celiac Sprue; Gluten Enteropathy
Intervention: Other: Gluten free diet
Sponsors: University of Nottingham; Nottingham University Hospitals NHS Trust; University of Salerno
Recruiting - Condition: Chicken-pox Illness (Varicella Virus Disease)
Interventions: Biological: Varilrix HSA-free; Biological: Varilrix™
Sponsor: GlaxoSmithKline
Completed - Condition: Health Behaviour
Intervention: Behavioral: Self-Incentive
Sponsor: University of Manchester
Completed - Condition: Asthma
Intervention:
Sponsors: Pneumacare Ltd; Cambridge University Hospitals NHS Foundation Trust; University Hospitals of North Midlands NHS Trust; Keele University
Completed - Conditions: Colorectal Cancer; Colorectal Adenoma
Interventions: Procedure: Flexible Sigmoidoscopy; Other: Fecal occult blood test
Sponsor: University of Dundee
Completed - Conditions: Vitamin D Deficiency; Osteoporosis
Intervention: Dietary Supplement: Cholecalciferol (Vitamin D3)
Sponsors: Sheffield Teaching Hospitals NHS Foundation Trust; National Osteoporosis Society
Active, not recruiting - Condition: Influenza
Intervention: Biological: MF59 - ATIV
Sponsors: University of Oxford; Emory University; VisMederi srl
Active, not recruiting - Conditions: Prostate Cancer; Prostate Biopsy; Genetic Counselling; Genetic Markers
Intervention: Procedure: Prostate MRI and Biopsy
Sponsors: Institute of Cancer Research, United Kingdom; Royal Marsden NHS Foundation Trust; University of Cambridge; University of Oxford; Queen Mary University of London
Recruiting - Conditions: Ulcer; Skin Ulcer; Wounds and Injuries
Interventions: Device: Epidermal grafting; Procedure: Split thickness skin grafting
Sponsor: University College, London
Completed - Conditions: Immature Newborn; Premature Birth
Intervention: Other: Image acquisition
Sponsors: University of Nottingham; Bill and Melinda Gates Foundation
Completed - Conditions: Myopia; Refractive Errors
Interventions: Procedure: Small incision lenticule extraction; Drug: Tobramycin and dexamethasone; Drug: Ofloxacin; Drug: Proxymetacaine 0.5%; Drug: Oxybuprocaine 0.4%
Sponsor: London Vision Clinic
Recruiting - Condition: Antitrypsin Deficiency Liver Disease
Interventions: Drug: ALN-AAT; Drug: Sterile Normal Saline (0.9% NaCl)
Sponsor: Alnylam Pharmaceuticals
Terminated - Condition: Hyperglycemia
Interventions: Dietary Supplement: Study nutritional drink; Dietary Supplement: Standard nutritional drink
Sponsors: University of Southampton; National University Hospital, Singapore; Auckland UniServices Ltd.; Singapore Institute for Clinical Sciences; National University, Singapore; Nestec Ltd.
Active, not recruiting - Condition: Nasal Carriage of Pneumococci
Intervention: Other: nasopharyngeal swab
Sponsor: Public Health England
Completed - Conditions: Corneal Thickness Measurement; Epithelial Thickness Measurement; Anterior Eye Segment Measurements
Intervention: Device: ArcScan Insight 100 very high-frequency digital ultrasound
Sponsors: London Vision Clinic; Arcscan, Inc.
Recruiting - Condition: Healthy Volunteer Study
Interventions: Drug: Nurofen for Children®; Drug: Algifor Dolo Junior®
Sponsor: Reckitt Benckiser Healthcare (UK) Limited
Completed - Condition: Respiratory Synctial Virus Infections
Interventions: Biological: GSK3389245A_LD GROUP; Biological: GSK3389245A_HD GROUP; Biological: Bexsero; Drug: Placebo
Sponsor: GlaxoSmithKline
Completed - Condition: Muscular Atrophy
Interventions: Behavioral: Step-reduction; Behavioral: Pre-training; Behavioral: Exercise snacking
Sponsor: University of Bath
Completed - Condition: Ebola Virus Disease
Interventions: Biological: ChAd3-EBO-Z; Biological: Ad26.ZEBOV
Sponsor: University of Oxford
Completed - Condition: Striae Distensae
Interventions: Device: ELAPR002f; Device: ELAPR002g; Device: Saline
Sponsor: Elastagen Pty Ltd
Completed - Condition: Diabetes Mellitus
Intervention: Other: Glucose-Potentiated Arginine-Induced Insulin Secretion
Sponsors: Royal Devon and Exeter NHS Foundation Trust; University of Exeter; University of Oxford; Oxford University Hospitals NHS Trust
Recruiting - Condition: Diabetes Mellitus
Interventions: Other: Oral Triglyceride Tolerance Test (OTTT); Procedure: Abdominal fat biopsy (optional)
Sponsors: Royal Devon and Exeter NHS Foundation Trust; University of Exeter
Completed - Conditions: Obesity; Type 2 Diabetes
Interventions: Device: Physical Activity Monitoring (Actiheart); Other: Energy Intake Monitoring; Other: Body Weight Monitoring; Procedure: Intravenous Cannulation; Procedure: Adipose Tissue Biopsy; Drug: Lidocaine Hydrochloride; Other: Post-Prandial Meal Tests; Radiation: DEXA Scan; Other: Actiheart Calibration; Other: Daily Calorie Restriction; Other: Intermittent Fasting with Weight Loss; Other: Intermittent Fasting without Weight Loss
Sponsor: University of Bath
Completed - Condition: Multiple Sclerosis
Interventions: Device: Magnetic Resonance Imaging; Drug: Prohance (Gadoteridol)
Sponsor: University of Nottingham
Recruiting - Conditions: Weight; Appetite
Interventions: Other: Active Diet Products; Other: Placebo Diet Products
Sponsors: Professor Jason Halford; University of Copenhagen; University Rovira i Virgili
Completed - Condition: Stroke
Intervention: Behavioral: Reading Training
Sponsor: University College London Hospitals
Active, not recruiting - Conditions: Qt Interval, Variation in; Adverse Effect of Selective Serotonin Reuptake Inhibitors
Intervention: Procedure: Electrocardiogram
Sponsor: University of Southampton
Completed - Condition: Infectious Diseases
Interventions: Biological: DTaP/IPV/Hib vaccine; Biological: 13 valent Pneumococcal Conjugate Vaccine; Biological: Rotavirus vaccine; Biological: 4-component Meningococcal B vaccine; Biological: Meningococcal C/Hib vaccine (MenC/Hib vaccine); Biological: Measles/Mumps/Rubella Vaccine (MMR vaccine)
Sponsors: University of Oxford; University College, London; Public Health England
Active, not recruiting - Condition: Healthy Volunteers
Interventions: Drug: Afolia; Drug: US Gonal-f®
Sponsor: Fertility Biotech AG
Completed - Condition: Infection by Streptococcus Group B
Intervention: Biological: GBS-NN vaccine
Sponsor: Minervax ApS
Completed - Conditions: Sarcopenia; Muscle Atrophy; Osteoporosis
Interventions: Other: RET; Dietary Supplement: Placebo; Dietary Supplement: Vitamin D3
Sponsors: University of Birmingham; University Hospital Birmingham; University of Surrey
Recruiting - Condition: Healthy
Interventions: Drug: Formulation A; Drug: Formulation B; Drug: Formulation C; Drug: Formulation D; Drug: Formulation E; Drug: Formulation F; Drug: Formulation M1; Drug: Formulation M2; Drug: Formulation M3; Drug: Formulation N1; Drug: Formulation N2; Drug: Formulation N3
Sponsor: Janssen Sciences Ireland UC
Completed - Condition: Dementia
Intervention:
Sponsor: Sheffield Teaching Hospitals NHS Foundation Trust
Recruiting - Condition: Persistent Physical Symptoms
Intervention: Behavioral: Integrated GP Care
Sponsors: King's College London; South London and Maudsley NHS Foundation Trust
Active, not recruiting - Condition: Urticaria
Interventions: Drug: GSK2646264 0.5% topical cream; Drug: GSK2646264 1% topical cream; Drug: Placebo
Sponsor: GlaxoSmithKline
Completed - Condition: Growth and Development
Interventions: Other: Emulsified cod liver oil product; Other: Non-emulsified cod liver oil product
Sponsors: GlaxoSmithKline; Hammersmith Medicines Research
Completed - Condition: Healthy
Interventions: Biological: MVA-BN-Filo; Biological: Ad26.ZEBOV; Biological: Placebo
Sponsor: Janssen Vaccines & Prevention B.V.
Completed - Conditions: Pregnancy; Pre-eclampsia; Gestational Diabetes; Depression; Metabolic Disorders; Pregnancy Induced Hypertension; Cardiovascular Disorders
Intervention:
Sponsors: Oxford University Hospitals NHS Trust; University of Oxford
Recruiting - Conditions: Meningococcal Vaccines; Meningococcal Infections; Neisseria Meningitidis; Factor H-binding Protein, Neisseria Meningitidi
Intervention: Biological: 4CMenB (Bexsero®) - Novartis Vaccines and Diagnostics
Sponsor: University of Oxford
Active, not recruiting - Condition: Asthma
Intervention: Procedure: Biofluid sampling
Sponsor: Boehringer Ingelheim
Completed - Condition: Metabolic Processes
Interventions: Dietary Supplement: Supradyn® (1RDA+CoQ10); Dietary Supplement: Supradyn® (3RDA); Dietary Supplement: Placebo
Sponsors: Northumbria University; Bayer
Completed - Condition: Crohn's Disease
Intervention:
Sponsor: University of Nottingham
Completed - Condition: Streptococcus Pneumoniae
Intervention: Biological: 10-valent pneumococcal conjugate vaccine
Sponsors: University of Oxford; Patan Academy of Health Sciences; University of Otago; Johns Hopkins Bloomberg School of Public Health
Completed - Condition: Eustachian Tube Dysfunction
Interventions: Other: Different objective clinical tests of Eustachian tube function; Other: Different patient-completed questionnaires relating to Eustachian tube dysfunction
Sponsor: Cambridge University Hospitals NHS Foundation Trust
Completed - Conditions: Dyspepsia; Irritable Bowel Syndrome
Intervention: Device: gammaCore®-G
Sponsor: ElectroCore INC
Completed - Conditions: Inflammatory Bowel Disease; Crohn's Disease; Ulcerative Colitis
Intervention:
Sponsor: St Stephens Aids Trust
Active, not recruiting - Conditions: Hepatitis C Infection; HIV Infection
Interventions: Biological: AdCh3NSmut1; Biological: MVA-NSmut; Biological: ChAdV63.HIVconsv; Biological: MVA.HIVconsv
Sponsors: University of Oxford; ReiThera Srl; GlaxoSmithKline
Completed - Conditions: Alcohol Addiction; Mouth Diseases
Interventions: Device: Drinksmeter; Behavioral: Brief Advice of Alcohol Use
Sponsors: King's College Hospital NHS Trust; South London and Maudsley NHS Foundation Trust
Terminated - Condition: Alpha-1 Antitrypsin Deficiency
Interventions: Drug: ARC-AAT Injection; Other: Placebo; Drug: Diphenhydramine
Sponsor: Arrowhead Pharmaceuticals
Terminated - Condition: Sarcopenia
Interventions: Drug: GLP-1; Drug: Insulin Actrapid; Dietary Supplement: Oral amino acids; Drug: GIP; Drug: Intravenous amino acids
Sponsor: University of Nottingham
Completed - Condition: Dentine Sensitivity
Interventions: Device: Calcium sodium phosphosilicate; Other: Sodium fluoride; Other: Sodium monofluorophosphate
Sponsor: GlaxoSmithKline
Completed - Condition: Healthy Volunteers
Interventions: Drug: LY2835219; Drug: ¹³C₈-LY2835219
Sponsor: Eli Lilly and Company
Completed - Condition: Visual Acuity
Intervention: Device: etafilcon - PVP (multi-focal)
Sponsor: Johnson & Johnson Vision Care, Inc.
Completed - Condition: Obesity
Intervention: Dietary Supplement: Counterweight Plus
Sponsors: NHS Greater Glasgow and Clyde; University of Glasgow
Completed - Conditions: Obesity; Dietary Modification
Intervention: Other: Daily extra water intake
Sponsor: ThinkWell
Not yet recruiting - Conditions: Typhoid Fever; Enteric Fever
Interventions: Biological: Vi-TCV; Biological: Vi-PS Vaccine; Biological: Control (Men ACWY)
Sponsor: University of Oxford
Active, not recruiting - Condition: Cardiovascular Diseases
Intervention:
Sponsors: Manchester University NHS Foundation Trust; University of Pittsburgh
Recruiting - Conditions: Healthy Subjects; Sickle Cell Disease
Interventions: Drug: GBT440; Drug: Placebo
Sponsor: Global Blood Therapeutics
Completed - Condition: Non Coeliac Gluten Sensitivity
Interventions: Other: Normal gluten containing bread; Other: Bread with reduced gliadins content; Other: Bread with reduced ATIs content; Other: Bread with reduced overall protein content
Sponsor: University of Aberdeen
Recruiting - Condition: Respiratory Syncytial Virus Infection
Interventions: Biological: ALX-0171; Other: Placebo
Sponsor: Ablynx
Completed - Condition: Delirium
Intervention:
Sponsor: Belfast Health and Social Care Trust
Active, not recruiting - Condition: Anemia
Intervention: Dietary Supplement: oral iron
Sponsors: dora pereira; University of Cambridge; Bangor University; University of Oxford
Completed - Condition: Arthritis
Interventions: Other: Prospective - Factors affecting sexual function pre-THR; Other: Retrospective- Factors affecting sexual function post-THR
Sponsor: University Hospital Southampton NHS Foundation Trust
Withdrawn - Condition: Type 2 Diabetes
Interventions: Dietary Supplement: Blackcurrants with polycal OGTT; Dietary Supplement: Greencurrants with polycal OGTT; Dietary Supplement: Blackcurrants with glucose OGTT; Dietary Supplement: Sugar matched water with polycal OGTT
Sponsor: University of Aberdeen
Recruiting - Condition: Infection
Intervention: Other: antivirals, antimicrobials, oral contraceptive, erectile dysfunction agents
Sponsor: Helen Reynolds
Recruiting - Conditions: Rectocele; Pelvic Organ Prolapse
Intervention: Device: Femmeze®
Sponsors: Royal Cornwall Hospitals Trust; Peninsula Health
Recruiting - Condition: Healthy
Interventions: Biological: D-Gam® (human anti-D immunoglobulin); Biological: Rhophylac® (human anti-D immunoglobulin)
Sponsor: Bio Products Laboratory
Completed - Condition: Healthy
Intervention: Biological: Gammaplex® (Human Normal Immunoglobulin)
Sponsor: Bio Products Laboratory
Completed - Conditions: Ebola; Ebola Zaire
Interventions: Biological: cAd3-EBO Z at 1 x 10^10 vp; Biological: cAd3-EBO Z at 2.5 x 10^10 vp; Biological: cAd3-EBO Z at 5 x 10^10 vp; Biological: 4.4x10^8 TCID50s MVA-BN® Filo; Biological: 2.2x10^8 TCID50s MVA-BN® Filo; Biological: 4.4 x 10^7 TCID50s MVA-BN® Filo
Sponsors: University of Oxford; Wellcome Trust; National Institute of Allergy and Infectious Diseases (NIAID)
Completed - Conditions: Energy Balance; Blood Glucose
Interventions: Behavioral: Exercise; Dietary Supplement: Breakfast
Sponsors: University of Bath; University of Stirling; University of Birmingham
Completed - Condition: Respiratory Syncytial Virus Infections
Interventions: Drug: ALS-008176; Drug: ALS-008112
Sponsor: Alios Biopharma Inc.
Completed - Condition: Major Depression (in Remission)
Intervention: Behavioral: Mindfulness-based Cognitive Therapy
Sponsor: University of Manchester
Completed - Conditions: Pre-eclampsia; Obesity; Raised Lipids; High Blood Pressure; Insulin Resistance; Gestational Diabetes; Small for Gestational Age; Stillbirth
Interventions: Behavioral: Targeted ESTEEM diet; Other: Non-randomised cohort
Sponsor: Queen Mary University of London
Completed - Condition: Psoriasis
Interventions: Biological: GSK2831781; Biological: Placebo
Sponsors: GlaxoSmithKline; Parexel
Completed - Conditions: Osteoarthritis; Chronic Pain
Interventions: Drug: Duloxetine; Drug: Remifentanil; Drug: Placebo (for Remifentanil); Drug: Placebo (for Duloxetine)
Sponsors: University of Nottingham; Arthritis Research UK
Completed - Condition: Melanoma
Intervention:
Sponsors: Moletest Scotland Ltd; Digital Health & Care Institute; NHS Lanarkshire
Completed - Conditions: Typhoid Fever; Paratyphoid Fever
Interventions: Biological: Salmonella Typhi; Biological: Salmonella Paratyphi
Sponsors: University of Oxford; University of Liverpool; Brigham and Women's Hospital
Active, not recruiting - Condition: Physical Activity
Intervention: Behavioral: Sit-stand workstation provision
Sponsors: Brunel University; Macmillan Canceer Support; Ergotron; Public Health England
Completed - Condition: Pain Relief in Labour
Interventions: Drug: Pethidine; Drug: Remifentanil
Sponsors: University of Birmingham; Heartlands Hospital; Good Hope Hospital; Birmingham Women's NHS Foundation Trust; York Hospital; University Hospital of North Midlands; Frimley Park Hospital; Bradford Royal Infirmary; Stoke Mandeville Hospital; Clinical Research and Trials Unit (Norfolk & Norwich University Hospital, UK); Medway Maritime Hospital; Northwick Park Hospital; Homerton University Hospital; City Hospital Birmingham; Warwick Hospital; University Hospital Coventry
Completed - Conditions: Glaucoma; Diagnostic Self-evaluation
Intervention:
Sponsor: University of Manchester
Completed - Condition: Healthy
Interventions: Behavioral: Concentric Exercise Training; Behavioral: Eccentric Exercise Training
Sponsors: University of Nottingham; Biotechnology and Biological Sciences Research Council
Completed - Condition: Critical Illness
Intervention:
Sponsors: University of Oxford; National Institute for Health Research, United Kingdom
Recruiting - Condition: Presbyopia Correction
Interventions: Device: Test (multi-focal); Device: Control (Sphere)
Sponsor: Johnson & Johnson Vision Care, Inc.
Completed - Conditions: Health; Hypertension; Chronic Kidney Disease
Intervention:
Sponsor: University of Edinburgh
Recruiting - Condition: Live Attenuated Influenza Vaccine
Intervention: Drug: Fluenz
Sponsors: Public Health England; Institute of Child Health
Completed - Condition: Oedema, Pulmonary
Interventions: Drug: GSK2798745 solution; Drug: GSK2798745 suspension; Drug: GSK2798745 capsule; Drug: Placebo solution; Drug: Placebo suspension; Drug: Placebo capsule
Sponsor: GlaxoSmithKline
Completed - Condition: Responses to Infant Immunisations
Interventions: Drug: Repevax; Drug: Boostrix-IPV
Sponsors: Public Health England; Institute of Child Health; St George's, University of London
Completed - Condition: Idiopathic Intracranial Hypertension
Interventions: Procedure: Bariatric surgery; Behavioral: Dietetic intervention
Sponsors: University of Birmingham; National Institute for Health Research, United Kingdom
Active, not recruiting - Conditions: Pneumococcal Infections; Pneumonia, Pneumococcal
Interventions: Biological: GEN-004 with Aluminum Hydroxide Adjuvant; Biological: Placebo; Biological: Streptococcus pneumoniae inoculation
Sponsor: Genocea Biosciences, Inc.
Completed - Condition: Healthy Subjects
Interventions: Drug: ACT-389949 40 mg; Drug: ACT-389949 200 mg; Drug: ACT-389949 800 mg; Drug: ACT-389949 (Group C1 dose to be selected); Drug: ACT-389949 (Group C2 dose to be selected); Drug: Placebo
Sponsor: Idorsia Pharmaceuticals Ltd.
Completed - Condition: Liver Disease
Intervention: Drug: Caffeine citrate
Sponsor: University of Birmingham
Withdrawn - Conditions: Alzheimer's Disease; Plaque, Amyloid
Intervention:
Sponsor: Janssen Research & Development, LLC
Recruiting - Condition: Healthy Cohort
Intervention: Behavioral: If I Were Jack
Sponsors: Queen's University, Belfast; University of Glasgow; Glasgow Caledonian University
Completed - Conditions: Preterm Birth; Hypertension
Intervention:
Sponsors: University of Oxford; British Heart Foundation
Completed - Condition: Osteoarthritis of the Knee
Intervention:
Sponsors: University of Nottingham; Arthritis Research UK; Federation Internationale de Football Association (FIFA); SPIRE Hospitals; Football Association (UK); Professional Football Association (UK)
Active, not recruiting - Condition: Meningitis
Intervention: Biological: 4CMenB
Sponsors: University of Oxford; Public Health England; Imperial College London; Novartis Vaccines; European Commission
Active, not recruiting - Condition: Bronchiectasis
Interventions: Drug: GSK2793660 solution; Drug: GSK2793660 capsule; Drug: Placebo solution; Drug: Placebo capsule
Sponsor: GlaxoSmithKline
Terminated - Condition: Nutritional Status
Interventions: Drug: Creatine; Drug: Placebo
Sponsor: GlaxoSmithKline
Completed - Conditions: Diabetes; Metabolism and Nutrition Disorder; Obesity
Interventions: Drug: semaglutide; Drug: placebo
Sponsor: Novo Nordisk A/S
Completed - Condition: Urologic Diseases
Interventions: Drug: Commercially available combination of dutasteride 0.5 mg and tamsulosin HCL 0.4 mg; Drug: Second generation dutasteride 0.5 mg and tamsulosin HCL 0.4 mg combination capsule
Sponsor: GlaxoSmithKline
Completed - Condition: Idiopathic Pulmonary Fibrosis
Intervention: Other: GSK2634673F
Sponsor: GlaxoSmithKline
Terminated - Condition: Urologic Diseases
Interventions: Drug: Commercially available combination of dutasteride 0.5 mg and tamsulosin HCL 0.4 mg; Drug: Second generation dutasteride 0.5 mg and tamsulosin HCL 0.4 mg combination capsule
Sponsor: GlaxoSmithKline
Completed - Condition: COPD
Intervention:
Sponsor: North Bristol NHS Trust
Completed - Conditions: Obesity; Metabolic Syndrome
Intervention: Behavioral: Meal pattern
Sponsor: University of Nottingham
Completed - Condition: Healthy
Intervention: Drug: lomitapide
Sponsor: Aegerion Pharmaceuticals, Inc.
Completed - Condition: Lung Cancer
Intervention: Device: CMPE Optical Sensor Device
Sponsor: Sally Falk
Completed - Condition: Asthma
Interventions: Device: VENTOLIN Mini-Spacer; Device: Aerochamber Plus spacer
Sponsor: GlaxoSmithKline
Completed - Condition: Vasculitis
Interventions: Drug: BQ123; Drug: BQ123/788; Drug: Placebo
Sponsors: University of Edinburgh; British Heart Foundation
Recruiting - Conditions: Hemophilia A; Hemophilia B
Interventions: Drug: ALN-AT3SC; Drug: Sterile Normal Saline (0.9% NaCl)
Sponsor: Alnylam Pharmaceuticals
Completed - Conditions: BCG Infection; Reaction - Vaccine; Immune Response
Interventions: Biological: BCG, NeisVac‐C®, Pediacel®, Infanrix™, Prevenar‐13®, Menitorix®, Priorix®, Rotarix®; Biological: NeisVac‐C®, Pediacel®, Infanrix™, Prevenar‐13®, Menitorix®, Priorix®, Rotarix®
Sponsor: University of Oxford
Completed - Condition: Colitis, Ulcerative
Interventions: Drug: GSK3050002; Drug: Placebo
Sponsors: GlaxoSmithKline; Eisai/Morphotek
Completed - Condition: Healthy Cohort
Intervention: Other: Randomisation of questionnaire receipt.
Sponsor: Queen's University, Belfast
Completed - Condition: Chronic Obstructive Pulmonary Disease
Interventions: Drug: d-cycloserine; Drug: placebo
Sponsors: University of Oxford; National Health Service, United Kingdom
Recruiting - Condition: Healthy Volunteers
Interventions: Drug: Evacetrapib; Drug: Pravastatin
Sponsor: Eli Lilly and Company
Completed - Condition: Hysteroscopy Technique
Interventions: Procedure: Vaginoscopy; Procedure: Standard Hysteroscopy
Sponsor: Birmingham Women's NHS Foundation Trust
Completed - Condition: HIV Infections
Intervention: Biological: rAAV1-PG9DP
Sponsors: International AIDS Vaccine Initiative; National Institute of Allergy and Infectious Diseases (NIAID); Children's Hospital of Philadelphia
Active, not recruiting - Conditions: Missing Teeth; Partial Edentulism
Intervention: Device: Dentures
Sponsors: Sheffield Teaching Hospitals NHS Foundation Trust; University of Sheffield; Juvora Dental Solutions
Completed - Condition: Healthy Cohort
Intervention: Other: Invitation letter randomisation
Sponsor: Queen's University, Belfast
Completed - Conditions: Bioavailability; Cardiovascular Health Status
Intervention: Other: Coffee
Sponsor: University of Leeds
Completed - Condition: Lung Cancer
Intervention: Biological: Early CDT Lung blood test
Sponsor: Stuart Schembri
Completed - Condition: Diabetes Mellitus
Intervention: Device: Microprobe glucose sensor
Sponsor: Imperial College London
Completed - Condition: Respiratory Syncytial Virus Infections
Intervention: Procedure: Blood sample
Sponsor: University of Oxford
Completed - Conditions: Invasive Streptococcal Infection; Invasive Group A Streptococcal Disease; Invasive Group B Streptococcal Disease; Necrotising Fasciitis
Intervention:
Sponsors: University of Oxford; Public Health England; Imperial College London
Active, not recruiting - Condition: Hypogonadotropism
Intervention: Drug: Testosterone
Sponsors: Transdermal Delivery Solutions Corp; Advanced Therapies Centre, The London Clinic
Enrolling by invitation - Condition: Influenza, Human
Intervention: Biological: Trivalent Influenza Vaccine
Sponsor: Seqirus
Completed - Condition: Influenza, Human
Intervention: Biological: Enzira® vaccine
Sponsor: Seqirus
Completed - Condition: Eletrophysiology of iPS-derived Cardiomyocytes
Intervention:
Sponsor: University of Dundee
Active, not recruiting - Conditions: Muscle Weakness; Pulmonary Arterial Hypertension
Intervention:
Sponsors: Imperial College London; Medical Research Council; Royal Brompton & Harefield NHS Foundation Trust
Terminated - Condition: Post-menopausal Osteoporosis
Interventions: Procedure: tooth extraction; Radiation: CBCT scan; Radiation: DXA scan; Radiation: Panoramic radiograph
Sponsor: University College, London
Withdrawn - Condition: ADV Infection Post Allo-HSCT
Intervention: Biological: Cytovir-ADV
Sponsors: Cell Medica Ltd; Technology Strategy Board, United Kingdom
Completed - Conditions: Pacemaker Complication; Congestive Heart Failure
Interventions: Other: Enhanced standard management; Other: Optimised heart failure management; Other: Standard management
Sponsors: University of Leeds; National Institute for Health Research, United Kingdom
Active, not recruiting - Condition: Prediabetes
Intervention: Other: Short text messages
Sponsors: Imperial College London; Barts & The London NHS Trust; Basildon and Thurrock University Hospitals NHS Foundation Trust; Lister Hospital; Torbay Hospital; Queen Alexandra Hospital; East Surrey Hospital; Pennine Acute Hospitals NHS Trust; West Suffolk Hospital; Derriford Hospital; Exeter Hospital; Milton Keynes University Hospital NHS Foundation Trust; Royal Cornwall Hospitals Trust; Queen Margaret Hospital, Dunfermline; Harrogate & District NHS Foundation Trust; Royal Berkshire NHS Foundation Trust; Rotherham NHS Trust
Completed - Condition: Chronic Kidney Disease
Intervention:
Sponsor: University of Edinburgh
Completed - Condition: Living Kidney Donors
Intervention: Other: Nephrectomy
Sponsors: Cambridge University Hospitals NHS Foundation Trust; British Heart Foundation; University Hospital Birmingham NHS Foundation Trust; North Bristol NHS Trust; University Hospitals Coventry and Warwickshire NHS Trust; St. George's Hospital, London; Glasgow Western Infirmary; Sheffield Teaching Hospitals NHS Foundation Trust; Manchester University NHS Foundation Trust
Active, not recruiting - Conditions: Type 1 Diabetes; Type 2 Diabetes
Interventions: Behavioral: Exercise; Procedure: Hyperglycemia
Sponsor: Rigshospitalet, Denmark
Withdrawn - Condition: Chronic Back Pain
Intervention:
Sponsor: University of Cambridge
Completed - Condition: Aortic Stenosis
Interventions: Other: Cardiac Magnetic Resonance Imaging; Other: Echocardiography; Other: 72 hour Holter Monitor
Sponsors: University of Edinburgh; British Heart Foundation
Completed - Conditions: Muscle Injury; Nerve Injury; Poliomyelitis; Leprosy; Cerebral Palsy
Interventions: Procedure: Interosseous route of TPTT; Procedure: Extra membranous route of TPTT
Sponsor: Iva Hauptmannova
Active, not recruiting - Condition: Li-Fraumeni Syndrome
Interventions: Other: Whole body MRI; Other: Psychological questionnaires
Sponsors: Institute of Cancer Research, United Kingdom; Cancer Research UK; National Institute for Health Research, United Kingdom
Completed - Condition: Prostate Cancer
Intervention:
Sponsors: Institute of Cancer Research, United Kingdom; Cancer Research UK; Royal Marsden NHS Foundation Trust
Recruiting - Condition: Tick-Borne Encephalitis
Intervention: Drug: TicoVac
Sponsor: University of Surrey
Completed - Conditions: Obesity; Psychological Disorders
Intervention: Behavioral: Psychological preparation
Sponsor: Sheffield Teaching Hospitals NHS Foundation Trust
Completed - Condition: Serogroup B Meningococcal Disease
Intervention: Biological: MenPF-1.
Sponsors: University of Oxford; Wellcome Trust; Norwegian Institute of Public Health
Active, not recruiting - Condition: Chronic Periodontitis
Interventions: Procedure: Non-surgical Subgingival Debridement (SD); Procedure: Simplified Papilla Preservation Flap; Procedure: Resective Periodontal Flap with Osseous Recontouring (RPFO)
Sponsor: Queen Mary University of London
Recruiting - Condition: Influenza, Human
Intervention: Biological: CSL Influenza Vaccine
Sponsor: Seqirus
Completed - Condition: Cardiovascular Disease
Intervention: Dietary Supplement: High/ Low Epicatechin Apples/ Apple Extract/ Granules
Sponsor: Queen's University, Belfast
Completed - Conditions: Adenocarcinoma of the Gastroesophageal Junction; Cervical Cancer; Endometrial Cancer; Esophageal Cancer; Fallopian Tube Cancer; Gastric Cancer; Ovarian Cancer; Sarcoma; Vaginal Cancer; Vulvar Cancer
Intervention:
Sponsors: Royal Marsden NHS Foundation Trust; University of Surrey
Completed - Condition: Healthy
Intervention:
Sponsors: University of Oxford; ReiThera Srl
Completed - Condition: Pregnancy
Intervention: Other: Ovulation predictions products
Sponsor: SPD Development Company Limited
Completed - Condition: Healthy Volunteers
Interventions: Drug: LY3016859 intravenous; Drug: Placebo intravenous; Drug: LY3016859 subcutaneous; Drug: Placebo subcutaneous
Sponsor: Eli Lilly and Company
Completed - Conditions: Intrahepatic Cholestasis of Pregnancy; Gestational Diabetes Mellitus
Intervention:
Sponsor: Imperial College London
Recruiting - Condition: Streptococcus Pneumoniae
Intervention:
Sponsor: Prof. Elizabeth Miller
Completed - Condition: Sepsis
Interventions: Biological: Lipopolysaccharide infusion; Other: saline
Sponsor: University of Nottingham
Completed - Conditions: Typhoid Fever; Enteric Fever; Typhoid
Interventions: Biological: Vaccine placebo (excipients only); Biological: Ty21a; Biological: M10ZH09 vaccine
Sponsors: University of Oxford; Wellcome Trust; Imperial College London; University of Maryland
Active, not recruiting - Conditions: Migraine; Cluster Headache; Control; Menstrual Migraine
Intervention:
Sponsor: Tim Young
Terminated - Condition: Healthy Volunteers
Intervention: Drug: Ketorolac tromethamine
Sponsor: Egalet Ltd
Completed - Condition: Infertility
Intervention:
Sponsors: Joanne Outtrim; Cambridge Temperature Concepts
Completed - Condition: Diabetes Mellitus, Type 2
Interventions: Drug: SRT3025; Drug: Placebo
Sponsor: Sirtris, a GSK Company
Completed - Condition: Aortic Stenosis
Intervention:
Sponsors: University of Edinburgh; NHS Lothian; British Heart Foundation
Completed - Conditions: Insulin Resistance; Obesity; Dyslipidemia
Intervention: Dietary Supplement: Orange Juice
Sponsors: University of Nottingham; Florida Department of Citrus
Completed - Condition: Knee Osteoarthritis
Interventions: Procedure: Unicompartmental Knee Replacement; Procedure: Total Knee Replacement
Sponsors: University of Oxford; University of Aberdeen
Active, not recruiting - Condition: Neonatal Encephalopathy
Intervention:
Sponsor: Thayyil, Sudhin
Completed - Conditions: Acellular Pertussis; Poliomyelitis; Tetanus; Diphtheria
Interventions: Biological: Boostrix PolioTM; Biological: RepevaxTM; Biological: PriorixTM
Sponsor: GlaxoSmithKline
Completed - Condition: Diabetes Mellitus, Type 1
Intervention: Procedure: two step hyperinsulinaemic glucose clamp study.
Sponsor: The Royal Bournemouth Hospital
Terminated - Condition: Insulin Resistance
Interventions: Dietary Supplement: High Flavanol Cocoa; Dietary Supplement: Low Flavanol Cocoa
Sponsors: University of Nottingham; Mars, Inc.
Completed - Conditions: Insulin Resistance; Obesity
Intervention: Dietary Supplement: orange juice
Sponsors: University of Nottingham; Florida Department of Citrus
Completed - Condition: Mild Cognitive Impairment
Interventions: Other: High Fat Low Carbohydrate Diet; Other: Low fat High Carbohydrate Diet
Sponsors: University of Nottingham; Mars, Inc.
Completed - Condition: Meningococcal Meningitis
Interventions: Biological: Menveo; Biological: MenACWY-TT
Sponsor: Public Health England
Completed - Condition: Influenza
Intervention: Biological: CSL's 2010/2011 Formulation of Enzira® Vaccine
Sponsor: Seqirus
Completed - Condition: Prostate Cancer
Interventions: Behavioral: Green tea drink; Dietary Supplement: green tea capsules; Other: Green tea placebo capsules; Dietary Supplement: Lycopene capsules; Other: Lycopene placebo capsules; Other: Tomato rich diet
Sponsor: University of Bristol
Completed - Condition: Breast Cancer Mortality
Intervention: Other: Invitation for breast screening
Sponsors: University of Oxford; Department of Health UK via Public Health England; Cancer Research UK via quinquennial core support; Medical Research Council via core support
Enrolling by invitation - Condition: Colorectal Cancer
Intervention:
Sponsors: Newcastle University; Northumbria Healthcare NHS Foundation Trust
Completed - Condition: Type 2 Diabetes
Interventions: Drug: Exenatide; Drug: Saline
Sponsor: University of Nottingham
Completed - Condition: Meningococcal Disease
Interventions: Biological: Meningococcal (group B) multicomponent recombinant adsorbed vaccine.; Biological: Meningococcal (group B) multicomponent recombinant adsorbed vaccine, without Outer Membrane Vesicles (OMV)
Sponsor: Novartis Vaccines
Completed - Condition: Pneumococcal Disease
Intervention:
Sponsor: Public Health England
Completed - Condition: Influenza
Interventions: Drug: CS-8958; Other: Placebo
Sponsors: Biota Scientific Management Pty Ltd; National Institute of Allergy and Infectious Diseases (NIAID)
Completed - Condition: Smoking
Interventions: Behavioral: EFT (Emotional Freedom Techniques); Behavioral: CBT (Cognitive Behavioral Therapy)
Sponsor: Soul Medicine Institute
Recruiting - Conditions: Meningococcal Meningitis, Serogroup A; Meningococcal Meningitis, Serogroup B; Meningococcal Meningitis, Serogroup C; Meningococcal Meningitis, Serogroup Y; Meningococcal Meningitis, Serogroup W
Intervention: Drug: meningococcal B vaccine & meningococcal ACYW conjugate vaccine
Sponsors: Prof. Elizabeth Miller; Novartis Vaccines
Completed - Condition: HPV Infections
Interventions: Biological: Cervarix; Biological: Gardasil
Sponsor: Prof. Elizabeth Miller
Completed - Conditions: Bipolar Depression; Bipolar Disorder
Interventions: Drug: Placebo; Drug: GSK1014802
Sponsor: Biogen
Completed - Condition: Influenza
Intervention: Biological: Inactivated Influenza Vaccine (2009 / 2010 formulation)
Sponsor: Seqirus
Completed - Condition: Healthy
Intervention: Biological: Engerix B®, a recombinant hepatitis B vaccine
Sponsor: University of Oxford
Completed - Conditions: Neisseria Meningitidis; Haemophilus Influenzae Type b
Interventions: Biological: GSK2197870A; Biological: Prevenar™; Biological: Menitorix™; Biological: Pediacel™; Biological: Menjugate™
Sponsor: GlaxoSmithKline
Completed - Conditions: Healthy; Adrenal Insufficiency; Hypopituitarism
Intervention: Drug: Synacthen (Tetracosactrin)
Sponsor: Cardiff University
Completed - Condition: Purpura, Thrombocytopaenic, Idiopathic
Interventions: Drug: Ciprofloxacin; Drug: Eltrombopag; Drug: Placebo
Sponsor: GlaxoSmithKline
Completed - Condition: Malaria
Interventions: Drug: GSK369796; Drug: Placebo
Sponsors: GlaxoSmithKline; Medicines for Malaria Venture
Completed - Condition: Post-menopausal Osteoporosis
Interventions: Drug: Ibandronate; Drug: Risedronate; Drug: Alendronate
Sponsors: Sheffield Teaching Hospitals NHS Foundation Trust; Procter and Gamble; University of Sheffield
Completed - Condition: Influenza
Interventions: Drug: CS-8958 formulated as dry powder; Other: Placebo
Sponsors: Biota Scientific Management Pty Ltd; National Institute of Allergy and Infectious Diseases (NIAID)
Completed - Conditions: Meningococcal Infections; Pneumococcal Infections
Interventions: Biological: NeisVacC (Meningococcal C conjugate vaccine); Biological: Menjugate (Meningococcal C conjugate vaccine)
Sponsors: Public Health England; Institute of Child Health; National Institute of Biological Standards and Control
Completed - Condition: Haemophilus Infections
Intervention:
Sponsor: Public Health England
Completed - Condition: Vaccination
Intervention: Biological: Menitorix (MenC and Hib conjugate)
Sponsor: Public Health England
Completed - Condition: Bipolar Disorder
Interventions: Drug: GSK drug; Other: Placebo; Other: Lamictal
Sponsor: Biogen
Completed - Condition: Common Cold/Flu
Intervention: Other: A commercially produced cordial drink
Sponsor: Cardiff University
Completed - Condition: Neisseria Meningitidis Serogroup B
Intervention: Biological: Meningococcal B Vaccine NZ
Sponsor: Public Health England
Completed - Condition: Influenza
Intervention: Biological: Fluarix
Sponsors: Public Health England; Royal Free and University College Medical School
Completed - Condition: Influenza
Interventions: Drug: CS-8958 formulated as dry powder; Other: Placebo
Sponsors: Biota Scientific Management Pty Ltd; National Institute of Allergy and Infectious Diseases (NIAID)
Completed - Condition: Infections, Papillomavirus
Interventions: Biological: Cervarix; Biological: Placebo control
Sponsor: GlaxoSmithKline
Completed - Condition: Healthy
Interventions: Dietary Supplement: 50ug selenium enriched yeast; Dietary Supplement: 100ug selenium enriched yeast; Dietary Supplement: 200ug selenium enriched yeast; Dietary Supplement: Control onion; Dietary Supplement: Enriched onion; Other: Placebo
Sponsors: Quadram Institute; Food Standards Agency, United Kingdom
Completed - Condition: Prostate Cancer in BRCA1 and BRCA2 Carriers
Interventions: Behavioral: PSA test; Procedure: Prostate Biopsy
Sponsors: Institute of Cancer Research, United Kingdom; Cancer Research UK; Royal Marsden NHS Foundation Trust; Ronald and Rita McAulay Foundation
Recruiting - Condition: Shigella Infection
Intervention: Biological: SC599
Sponsor: Institut Pasteur
Completed - Conditions: Pneumococcal Infections; Meningococcal Infections
Interventions: Biological: menjugate; Biological: Men C conjugate vaccine; Biological: Men C conjugate; Biological: Men C Conjugate
Sponsor: Public Health England
Completed - Conditions: Frailty; Sarcopenia
Interventions: Drug: Transdermal testosterone gel (Testogel 1% ); Drug: Matched transdermal placebo gel
Sponsors: Manchester University NHS Foundation Trust; University of Manchester; Bayer
Completed
Clinical Trial Locations