 |
- Condition: Healthy Volunteer
Intervention: Drug: [14C] MT-7117
Sponsor: Mitsubishi Tanabe Pharma Development America, Inc.
Completed - A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of JNJ-48816274Condition: Healthy
Interventions: Drug: JNJ-48816274; Drug: Placebo
Sponsor: Janssen-Cilag International NV
Completed - Conditions: Brugada Syndrome; Sudden Death
Intervention: Drug: Ajmaline
Sponsor: St George's, University of London
Recruiting - Conditions: Sepsis; Septic Shock; Sepsis Syndrome; Severe Sepsis
Intervention: Diagnostic Test: Septic
Sponsors: University of Leicester; The Royal College of Anaesthetists; University Hospitals, Leicester
Recruiting - Condition: Healthy-volunteers
Interventions: Drug: Rozanolixizumab; Drug: Placebo
Sponsor: UCB Biopharma S.P.R.L.
Recruiting - Condition: Healthy
Interventions: Drug: LEO 32731 modified release tablet; Drug: LEO 32731 blend, hard capsule; Drug: LEO 32731 API, hard capsule; Drug: LEO 32731 soft capsule; Drug: LEO 32731 gastro-resistant capsule; Drug: LEO 32731; Other: Placebo
Sponsor: LEO Pharma
Recruiting - Condition: Healthy
Intervention: Diagnostic Test: MRI and concomitant perfused manometry of bowel motility
Sponsors: University of Nottingham; Food and Drug Administration (FDA); University of Michigan
Completed - Condition: Healthy
Interventions: Drug: AL-794; Drug: Placebo
Sponsor: Alios Biopharma Inc.
Terminated - Condition: Idiopathic Pulmonary Arterial Hypertension
Interventions: Drug: (Pyr1)apelin-13; Drug: Saline
Sponsor: Imperial College London
Completed - Condition: Healthy Volunteer
Interventions: Drug: BIIB095; Drug: Placebo
Sponsor: Biogen
Completed - Condition: Healthy
Interventions: Drug: LY3002815; Drug: Placebo
Sponsor: Eli Lilly and Company
Terminated - Condition: Healthy Volunteer
Interventions: Drug: CC-99677; Other: Placebo
Sponsor: Celgene
Recruiting - Condition: Inner Ear Disease
Interventions: Drug: SENS-401; Drug: Placebo
Sponsors: Simbec Research; Sensorion
Completed - Condition: Healthy
Intervention: Drug: BDM-2 in Bottle (50 mg - 3600 mg); oral suspension
Sponsors: Hivih; Venn Life Sciences
Completed - Condition: Healthy
Interventions: Drug: JNJ-64417184; Drug: Placebo
Sponsor: Janssen BioPharma, Inc.
Recruiting - Conditions: Healthy Volunteers; Osteoarthritis
Interventions: Drug: LEVI-04; Drug: Placebo
Sponsors: Levicept; Hammersmith Medicines Research
Recruiting - Condition: Healthy Volunteers
Interventions: Drug: SPR720 for SAD; Drug: Placebo for SAD; Drug: SPR720 for MAD; Drug: Placebo for MAD
Sponsors: Spero Therapeutics; Simbec Research
Recruiting - Condition: Healthy Volunteer
Interventions: Biological: MEDI4920 3 mg; Biological: MEDI4920 10 mg; Biological: MEDI4920 30 mg; Biological: MEDI4920 100 mg; Biological: MEDI4920 300 mg; Biological: MEDI4920 1000 mg; Biological: MEDI4920 3000 mg; Other: Placebo
Sponsor: MedImmune LLC
Completed - Conditions: Healthy; Type2 Diabetes
Intervention: Other: Dietary Intervention
Sponsors: University of Aberdeen; NHS Grampian
Recruiting - Condition: Healthy
Interventions: Drug: Fluticasone propionate; Device: Accuhaler
Sponsors: University Hospitals, Leicester; Genentech, Inc.
Active, not recruiting - Condition: Healthy Volunteers
Interventions: Drug: MB02; Drug: US licenced Avastin®; Drug: EU approved Avastin®
Sponsor: mAbxience S.A
Active, not recruiting - Condition: Healthy
Intervention: Drug: Aprepitant 125 mg
Sponsor: Nuformix Technologies Limited
Active, not recruiting - Condition: Healthy Subjects
Interventions: Drug: AC-084; Drug: Placebo
Sponsor: Idorsia Pharmaceuticals Ltd.
Terminated - Condition: Healthy
Interventions: Drug: HTL0030310; Drug: Pasireotide; Drug: Placebo
Sponsor: Heptares Therapeutics Limited
Active, not recruiting - Condition: Healthy
Intervention: Dietary Supplement: Molkosan
Sponsors: University of Aberdeen; A. Vogel
Completed - Condition: Healthy
Intervention: Drug: 14C-CORT125281
Sponsor: Corcept Therapeutics
Completed - Condition: Healthy
Interventions: Drug: MT-6345; Drug: MT-6345 Placebo
Sponsor: Mitsubishi Tanabe Pharma Development America, Inc.
Recruiting - Condition: Healthy
Interventions: Drug: Lu AF35700; Drug: Lu AF35700 iv
Sponsor: H. Lundbeck A/S
Completed - Condition: Healthy
Intervention: Drug: Evenamide
Sponsor: Newron Pharmaceuticals SPA
Recruiting - Condition: Healthy
Interventions: Other: Oral Placebo; Other: Oral Protein; Other: Enteral Protein
Sponsor: University of Exeter
Completed - Condition: Healthy
Interventions: Drug: Placebo; Drug: Lu AF76432
Sponsor: H. Lundbeck A/S
Completed - Condition: Healthy
Interventions: Drug: CORT118335, 25 mg; Drug: Prednisone Oral Tablet; Drug: Glucose; Drug: Placebo oral suspension; Drug: CORT118335, 75mg; Drug: CORT118335, 225mg; Drug: CORT118335, 675mg; Drug: CORT118335, 600mg; Drug: CORT118335, 630mg; Drug: CORT118335, 375mg; Drug: CORT118335, 100mg; Drug: CORT118335, 300mg; Drug: CORT118335, 900mg; Drug: CORT118335, 150mg; Drug: CORT118335, 1500mg; Drug: Placebo oral capsule; Drug: CORT118335, dose to be determined
Sponsor: Corcept Therapeutics
Completed - Condition: Healthy
Interventions: Drug: Reboxetine; Drug: Rivastigmine; Drug: Placebo oral tablet
Sponsor: University of Oxford
Not yet recruiting - Condition: Healthy
Interventions: Drug: Midazolam; Drug: ID-082
Sponsor: Idorsia Pharmaceuticals Ltd.
Completed - Condition: Healthy
Interventions: Drug: CORT118335 Oral; Drug: 14C-CORT118335 intravenous; Drug: 14C-CORT118335 oral
Sponsor: Corcept Therapeutics
Recruiting - Condition: Healthy Subjects
Interventions: Drug: TP-6076; Procedure: Bronchoalveolar lavage
Sponsors: Tetraphase Pharmaceuticals, Inc.; PRA Health Sciences
Recruiting - Condition: Healthy
Interventions: Dietary Supplement: Wild Blueberry Powder; Dietary Supplement: Placebo
Sponsors: King's College London; University of Reading
Recruiting - Condition: Healthy
Interventions: Drug: HTL0014242; Drug: Placebo oral capsule
Sponsors: Heptares Therapeutics Limited; Covance
Recruiting - Condition: Healthy Participants
Intervention: Drug: BMS-986165
Sponsor: Bristol-Myers Squibb
Recruiting - Condition: Healthy
Intervention: Drug: teverelix TFA
Sponsor: Antev Ltd.
Active, not recruiting - Condition: Healthy Subjects
Intervention: Drug: pracinostat
Sponsors: Helsinn Healthcare SA; Quotient Sciences
Enrolling by invitation - Condition: Healthy Volunteers
Intervention: Dietary Supplement: SPM Active
Sponsors: Queen Mary University of London; Metagenics, Inc.
Active, not recruiting - Condition: Healthy Volunteers
Intervention: Drug: Tenofovir exalidex (TXL)
Sponsor: ContraVir Pharmaceuticals, Inc.
Completed - Condition: Healthy
Interventions: Drug: LY3305677; Drug: Placebo
Sponsor: Eli Lilly and Company
Completed - Condition: Healthy Subjects
Interventions: Drug: nangibotide; Drug: Placebo
Sponsors: Inotrem; Richmond Pharmacology Limited
Completed - Condition: Healthy Volunteer Study
Intervention: Drug: AST-008
Sponsor: Exicure, Inc.
Completed - Condition: Healthy Subjects
Interventions: Drug: BOS172767 tablets; Drug: BOS172767 liquid capsules; Drug: BOS172767 micronized capsules; Drug: BOS172767 immediate release capsules; Drug: BOS172767 matching placebo capsules; Drug: BOS172767 matching placebo tablets; Drug: Rabeprazole
Sponsor: Boston Pharmaceuticals
Completed - Condition: Healthy
Interventions: Dietary Supplement: B-GOS; Dietary Supplement: Maltodextrin
Sponsors: Clasado Limited; General Hospital, States of Jersey
Completed - Condition: Healthy Subjects
Interventions: Drug: ID-085; Drug: Placebo oral capsule
Sponsor: Idorsia Pharmaceuticals Ltd.
Completed - Condition: Healthy Volunteers
Interventions: Drug: AZD9977; Other: Placebo
Sponsors: AstraZeneca; Parexel
Completed - Condition: Healthy
Intervention: Drug: PF-06427878
Sponsor: Pfizer
Completed - Condition: Healthy Participants
Interventions: Drug: AJM347; Drug: Placebo
Sponsor: EA Pharma Co., Ltd.
Completed - Condition: Complement Mediated Bacterial Killing in Healthy Adults
Intervention:
Sponsors: University of Oxford; Wellcome Trust
Recruiting - Condition: Healthy
Interventions: Drug: GLPG1690; Drug: Itraconazole; Drug: Voriconazole
Sponsor: Galapagos NV
Completed - Condition: Healthy Japanese Volunteers
Interventions: Drug: UCB0107; Other: Placebo
Sponsor: UCB Biopharma S.P.R.L.
Completed - Condition: Healthy Male Participants
Intervention: Drug: [14C]-E6007
Sponsor: EA Pharma Co., Ltd.
Completed - Condition: Healthy Volunteers
Interventions: Drug: Cortexolone 17α-propionate solution; Drug: Placebo
Sponsor: Cassiopea SpA
Completed - Condition: Healthy Men and Women
Interventions: Dietary Supplement: Placebo; Dietary Supplement: Concord Grape extract 1; Dietary Supplement: Concord Grape extract 2
Sponsors: King's College London; Naturex-Dbs
Recruiting - Condition: Healthy Volunteer
Interventions: Drug: Folic Acid; Drug: GDC-0853; Drug: Methotrexate; Drug: Rabeprazole
Sponsor: Genentech, Inc.
Completed - Condition: Healthy Volunteers
Interventions: Drug: GDC-0334; Drug: Placebo
Sponsor: Genentech, Inc.
Recruiting - Condition: Healthy Volunteers
Interventions: Drug: GDC-0853; Drug: Rabeprazole
Sponsor: Genentech, Inc.
Completed - Condition: Healthy Volunteers
Interventions: Drug: MEDI7219; Drug: Placebo; Drug: Formulation without Active Drug
Sponsor: MedImmune LLC
Recruiting - Condition: Hepatitis C
Interventions: Biological: ChAd3-hliNSmut; Biological: MVA-hliNSmut
Sponsors: University of Oxford; Oxford University Hospitals NHS Trust; ReiThera Srl; European Commission; GlaxoSmithKline
Recruiting - Condition: Healthy
Intervention: Drug: 14C labeled PXL770
Sponsor: Poxel SA
Completed - Condition: Healthy Subjects
Interventions: Drug: ACT-389949 40 mg; Drug: ACT-389949 200 mg; Drug: ACT-389949 800 mg; Drug: ACT-389949 (Group C1 dose to be selected); Drug: ACT-389949 (Group C2 dose to be selected); Drug: Placebo
Sponsor: Idorsia Pharmaceuticals Ltd.
Completed - Condition: Burns
Interventions: Other: Lactulose and Mannitol solution; Other: Sucralose
Sponsor: GlaxoSmithKline
Terminated - Condition: Pharmacokinetic Study in Healthy Male Volunteers
Interventions: Drug: Orvepitant; Drug: Itraconazole
Sponsor: Nerre Therapeutics Ltd.
Completed - Condition: Gastroesophageal Reflux
Intervention: Device: Bravo
Sponsor: Guy's and St Thomas' NHS Foundation Trust
Recruiting - Conditions: Hyperglycemia, Postprandial; Healthy
Interventions: Dietary Supplement: Enriched pomegranate juice; Dietary Supplement: Placebo beverage
Sponsor: University of Leeds
Recruiting - Condition: Overweight/Obesity
Interventions: Behavioral: Website and pedometer intervention; Other: Control
Sponsor: University of Bath
Completed - Condition: Healthy
Interventions: Drug: DS-1971a; Drug: placebo
Sponsor: Daiichi Sankyo, Inc.
Completed - Conditions: Healthy Male Subjects; Cardiovascular Disease
Interventions: Drug: AZD5718 oral suspension crystalline form (1 to 100 mg/mL) (Part A); Drug: AZD5718 oral suspension amorphous (1 to 100 mg/mL) (Part A); Drug: AZD5718 placebo oral suspension; Drug: AZD5718 oral suspension amorphous (1 to 100 mg/mL) (Part B)
Sponsor: AstraZeneca
Completed - Condition: Healthy
Interventions: Drug: LY3314814; Drug: [13C415N3] LY3314814
Sponsors: Eli Lilly and Company; AstraZeneca
Completed - Condition: Healthy
Interventions: Other: Postabsorptive; Other: Postprandial; Procedure: Immobilisation
Sponsor: University of Exeter
Recruiting - Condition: Healthy
Interventions: Drug: Aramchol; Drug: Midazolam; Drug: Atorvastatin
Sponsors: Galmed Pharmaceuticals Ltd; Hammersmith Medicines Research; Analyst Research Laboratories; Alderley Analytical; Diamond Pharma Services Regulatory Affairs Consultancy
Completed - Condition: Pulmonary Disease, Chronic Obstructive
Interventions: Drug: CCI15106; Drug: Placebo
Sponsor: GlaxoSmithKline
Completed - Condition: Healthy
Interventions: Drug: Vortioxetine IV; Drug: Vortioxetine SLA; Drug: Vortioxetine SLB; Drug: Vortioxetine SLC
Sponsor: H. Lundbeck A/S
Recruiting - Condition: Safety, Pharmacokinetics, Pharmacodynamics, Food Effect
Interventions: Drug: AZD7986, oral solution, 1 to 50 mg/mL; Drug: Placebo, oral solution
Sponsor: AstraZeneca
Completed - Condition: Oedema, Pulmonary
Interventions: Drug: GSK2798745 solution; Drug: GSK2798745 suspension; Drug: GSK2798745 capsule; Drug: Placebo solution; Drug: Placebo suspension; Drug: Placebo capsule
Sponsor: GlaxoSmithKline
Completed - Condition: Healthy
Interventions: Drug: GLPG1690 film-coated tablets; Drug: [14C]-GLPG1690 solution for infusion; Drug: [14C]-GLPG1690 capsules
Sponsor: Galapagos NV
Completed - Condition: Optokinetic Nystagmus
Intervention: Device: CAVA
Sponsors: Emily Woodhouse; University of East Anglia; Medical Research Council
Recruiting - Condition: Healthy Volunteers
Intervention: Drug: ORIC-101
Sponsor: Oric Pharmaceuticals
Completed - Condition: Healthy
Interventions: Drug: PCS499; Drug: Trental
Sponsors: Processa Pharmaceuticals; Quotient Sciences
Completed - Condition: Pulmonary Disease, Chronic Obstructive
Interventions: Drug: GSK2269557 500 µg; Drug: GSK2269557 750 µg
Sponsor: GlaxoSmithKline
Completed - Condition: Healthy
Interventions: Drug: LY3143753 (Part A); Drug: LY3185643 (Part B); Drug: Placebo (Part A and Part B); Drug: rGlucagon (Part B)
Sponsor: Eli Lilly and Company
Completed - Condition: Healthy Volunteers
Interventions: Biological: YQ23; Biological: Matching Placebo
Sponsor: New B Innovation Limited
Recruiting - Condition: Healthy
Interventions: Biological: Ad26.RSV.preF; Drug: Placebo
Sponsor: Janssen Vaccines & Prevention B.V.
Completed - Condition: Healthy Volunteers
Interventions: Drug: LY2835219; Drug: ¹³C₈-LY2835219
Sponsor: Eli Lilly and Company
Completed - Condition: Healthy Subjects
Intervention: Drug: Uproleselan
Sponsors: GlycoMimetics Incorporated; Quotient Sciences
Completed - Condition: Healthy Volunteers
Interventions: Drug: AZD9977 Oral suspension (reference); Drug: AZD9977 capsule; Drug: AZD9977 ER capsule (fastvrate); Drug: AZD9977 ER capsule (Int. rate)
Sponsors: AstraZeneca; Parexel
Completed - Condition: Healthy Volunteers
Interventions: Drug: REGN3918; Drug: Placebo
Sponsor: Regeneron Pharmaceuticals
Completed - Condition: Healthy Volunteers
Interventions: Drug: Evacetrapib Tablet; Drug: Evacetrapib Intravenous
Sponsor: Eli Lilly and Company
Completed - Condition: Healthy Subjects
Interventions: Drug: IONIS-ENaCRx; Drug: Placebo
Sponsor: Ionis Pharmaceuticals, Inc.
Recruiting - Condition: Healthy Volunteers
Interventions: Biological: BGB149; Biological: Placebo
Sponsor: BerGenBio ASA
Recruiting - Condition: Healthy Volunteers
Interventions: Drug: LY3016859 intravenous; Drug: Placebo intravenous; Drug: LY3016859 subcutaneous; Drug: Placebo subcutaneous
Sponsor: Eli Lilly and Company
Completed - Condition: Study is Being Conducted in Healthy Volunteers
Interventions: Drug: Symbicort pMDI with spacer device; Drug: Symbicort pMDI without spacer device
Sponsors: AstraZeneca; Parexel
Completed - Condition: Healthy Volunteers
Interventions: Drug: AZD4635 50 mg nano-suspension (reference); Drug: AZD4635 solid oral formulation - fasted; Drug: AZD4635 solid oral formulation - fed; Drug: Lansoprazole and AZD4635 50 mg solid oral formulation; Drug: AZD4635 solid oral formulation variant 1 - fasted; Drug: AZD4635 solid oral formulation variant 2 - fasted; Drug: [14C] AZD4635 IV microtracer - fasted
Sponsors: AstraZeneca; Quotient Sciences
Completed - Condition: Healthy
Intervention: Drug: Zinc carnosine
Sponsors: Imperial College London; Wexham GI Trust
Recruiting - Conditions: Diabetes; Diabetes Mellitus, Type 2; Healthy
Interventions: Drug: NN9924 (oral); Drug: placebo; Drug: NN9924 (s.c.); Drug: NN9924 (i.v.)
Sponsor: Novo Nordisk A/S
Completed - Conditions: Ebola; Ebola Zaire
Interventions: Biological: cAd3-EBO Z at 1 x 10^10 vp; Biological: cAd3-EBO Z at 2.5 x 10^10 vp; Biological: cAd3-EBO Z at 5 x 10^10 vp; Biological: 4.4x10^8 TCID50s MVA-BN® Filo; Biological: 2.2x10^8 TCID50s MVA-BN® Filo; Biological: 4.4 x 10^7 TCID50s MVA-BN® Filo
Sponsors: University of Oxford; Wellcome Trust; National Institute of Allergy and Infectious Diseases (NIAID)
Completed - Condition: Cerebrovascular Circulation
Interventions: Drug: Darolutamide (BAY1841788); Drug: Enzalutamide; Other: Placebo
Sponsor: Bayer
Active, not recruiting - Condition: Healthy
Interventions: Drug: HTL0016878; Drug: Placebo - Concentrate
Sponsors: Heptares Therapeutics Limited; Allergan
Recruiting - Condition: Influenza, Human
Intervention: Biological: CSL Influenza Vaccine
Sponsor: Seqirus
Completed - Condition: Atopic Dermatitis
Interventions: Drug: LEO 138559; Drug: LEO 138559 placebo
Sponsor: LEO Pharma
Recruiting - Conditions: Type 2 Diabetes Mellitus; Healthy Subjects
Interventions: Drug: Sotagliflozin (SAR439954); Drug: 14C-microtracer; Drug: Charcoal
Sponsor: Sanofi
Completed - Conditions: Part I (SAD) - Healthy Subjects; Part II (MAD) - Chronic Obstructive Pulmonary Disease; Part III (J-SD) - Healthy Japanese Subjects
Interventions: Drug: MEDI3506; Drug: placebo
Sponsor: MedImmune LLC
Active, not recruiting - Conditions: Healthy Volunteers; Idiopathic Pulmonary Fibrosis
Interventions: Drug: IDL-2965 Oral Capsule; Drug: Placebos
Sponsor: Indalo Therapeutics, Inc.
Recruiting - Condition: Safety and Tolerability
Interventions: Drug: GB1211; Drug: Placebo
Sponsor: Galecto Biotech AB
Recruiting - Conditions: Healthy Smokers; Healthy Non-smokers; Patients With Mild Asthma; Patints With COPD (GOLD II)
Interventions: Procedure: Induced Sputum; Procedure: Exhaled Nitric Oxide; Procedure: Nasal Nitric Oxide; Procedure: Blood Tests; Procedure: 24hr Urine Samples; Procedure: Exhaled Breath Condensate; Procedure: Spirometry
Sponsors: Imperial College London; GlaxoSmithKline
Completed - Condition: Hypertension, Pulmonary
Intervention: Drug: [11C]-GSK2256098 500 MBq
Sponsor: GlaxoSmithKline
Completed - Conditions: Crohn Disease; Mycobacterium Avium Subspecies Paratuberculosis
Interventions: Biological: ChAdOx2 HAV; Biological: MVA HAV
Sponsor: University of Oxford
Recruiting - Conditions: Psoriasis; Atopic Dermatitis
Interventions: Other: EDP1066; Drug: Placebo oral capsule
Sponsor: Evelo Biosciences, Inc.
Recruiting - Condition: Autoimmune Diseases
Interventions: Drug: GSK2982772 capsule; Drug: Placebo capsule
Sponsor: GlaxoSmithKline
Completed - Condition: Viral Upper Respiratory Tract Infection
Interventions: Drug: PrEP-001; Other: Placebo
Sponsors: Prep Biopharm Limited; Hvivo
Completed - Condition: Cognition
Intervention: Behavioral: Participants self-administered questionnaire and assessment
Sponsor: GlaxoSmithKline
Terminated - Condition: Healthy
Interventions: Dietary Supplement: Strawberry juice with Inulin; Dietary Supplement: Strawberry Juice; Dietary Supplement: Inulin
Sponsors: University of Glasgow; Scottish Universities Environmental Research Centre
Completed - Conditions: Molecular Mechanisms of Pharmacological Action; Depression; Depressive Disorder; Mood Disorders; Mental Disorder; Antidepressive Agents; Cognition
Interventions: Drug: Prucalopride; Other: Placebo
Sponsor: University of Oxford
Completed - Condition: Arthritis, Rheumatoid
Interventions: Biological: Cantharidin; Biological: Lipopolysaccharide; Biological: Granulocyte-Macrophage Colony-Stimulating Factor; Drug: Saline Solution
Sponsor: GlaxoSmithKline
Completed - Condition: Malaria
Interventions: Drug: GSK369796; Drug: Placebo
Sponsors: GlaxoSmithKline; Medicines for Malaria Venture
Completed - Condition: Healthy
Intervention: Drug: AK0529
Sponsor: Ark Biosciences Inc.
Completed - Condition: Healthy Volunteers
Interventions: Drug: XPF-008; Drug: Microcrystalline Cellulose
Sponsor: Xenon Pharmaceuticals Inc.
Recruiting - Condition: Breast Cancer
Interventions: Other: MRI; Other: PET/MRI
Sponsor: Cambridge University Hospitals NHS Foundation Trust
Not yet recruiting - Condition: Healthy
Interventions: Drug: ODM-203 (Period 1); Drug: ODM-203 (Period 2); Drug: ODM-203 (Periods 3-6)
Sponsors: Orion Corporation, Orion Pharma; Quotient Clinical
Completed - Condition: Healthy
Intervention: Drug: tiotropium pMDI
Sponsor: 3M
Completed - Condition: Healthy
Intervention: Drug: Tiotropium
Sponsors: 3M; Simbec Research
Completed - Condition: Healthy
Interventions: Drug: CORT125281, 40mg, fasted; Drug: Prednisone 25mg, fasted; Drug: Placebo oral capsule, fasted; Drug: Pioglitazone 15mg Tablet; Drug: Placebo oral capsule, fed; Drug: Prednisone 25mg, fed; Drug: CORT125281, 120mg, fasted; Drug: CORT125281, 360mg, fasted; Drug: CORT125281, 720mg, fasted; Drug: CORT125281, 360mg, fed; Drug: CORT125281, 360mg; Drug: CORT125281, 120mg; Drug: CORT125281, 180mg; Drug: CORT125281, 240mg; Drug: Placebo oral capsule
Sponsor: Corcept Therapeutics
Completed - Condition: Healthy
Intervention: Drug: Tiotropium
Sponsors: 3M; Quotient Clinical
Completed - Condition: Healthy Volunteers
Intervention: Drug: Varlitinib
Sponsor: Aslan Pharmaceuticals
Completed - Condition: Healthy
Interventions: Drug: Imeglimin; Drug: Cimetidine
Sponsor: Poxel SA
Completed - Condition: Infection, Human Immunodeficiency Virus
Interventions: Drug: GSK3640254; Drug: Placebo
Sponsors: ViiV Healthcare; GlaxoSmithKline
Completed - Condition: Healthy Subjects
Intervention: Drug: Cefepime 2 gram
Sponsor: Allecra
Recruiting - Condition: Healthy Volunteers
Interventions: Biological: ABY-039; Biological: Placebo
Sponsors: Affibody; Parexel
Recruiting - Conditions: Molecular Mechanisms of Pharmacological Action; Depression; Depressive Disorder; Mood Disorders; Mental Disorders; Antidepressive Agents; Cognition
Interventions: Drug: Prucalopride; Other: Placebo
Sponsor: University of Oxford
Recruiting - Condition: Hepatitis B
Interventions: Drug: GSK3389404; Drug: Matching Placebo
Sponsor: GlaxoSmithKline
Completed - Condition: Healthy Volunteer
Interventions: Drug: MT-8554 Low dose; Drug: MT-8554 High dose; Drug: Placebo
Sponsor: Mitsubishi Tanabe Pharma Development America, Inc.
Completed - Condition: Healthy Volunteers
Interventions: Drug: Tolcapone; Drug: Tolcapone Modified Release Prototype; Drug: Tolcapone Divided Dose
Sponsors: Corino Therapeutics, Inc.; Quotient Sciences
Completed - Condition: Tuberculosis
Interventions: Biological: BCG Danish; Other: Saline placebo
Sponsors: University of Oxford; Wellcome Trust; National Institute for Health Research, United Kingdom
Recruiting - Condition: Healthy Males
Intervention: Drug: Firibastat
Sponsors: Quantum Genomics SA; Quotient Sciences
Recruiting - Condition: Pancreatitis, Acute Necrotizing
Interventions: Drug: GSK3335065; Drug: Placebo
Sponsor: GlaxoSmithKline
Terminated - Conditions: Psoriasis; Atopic Dermatitis
Interventions: Drug: EDP1815; Drug: Placebo oral capsule
Sponsor: Evelo Biosciences, Inc.
Recruiting - Condition: Chikungunya Fever
Intervention: Biological: ChAdOx1 Chik
Sponsor: University of Oxford
Recruiting - Condition: Asthma
Interventions: Drug: Itraconazole Powder; Drug: Itraconazole 200 mg
Sponsor: Pulmatrix Inc.
Completed - Condition: Tuberculosis
Interventions: Drug: GSK3036656; Drug: Placebo
Sponsor: GlaxoSmithKline
Completed - Condition: Healthy
Intervention: Drug: 200 mg Ibuprofen acid orodispersible tablet
Sponsors: Reckitt Benckiser Healthcare (UK) Limited; Simbec Research
Terminated - Condition: Chronic Obstructive Pulmonary Disease
Interventions: Drug: CHF6297 (Part 1 - SAD); Drug: Placebo (Part 1 - SAD); Drug: CHF6297 (Part 2 - MAD); Drug: Placebo (Part 2 - MAD); Drug: CHF6297 (Part 3); Drug: Placebo (Part 3); Drug: CHF6297 (Part 4); Drug: Placebo (Part 4)
Sponsor: Chiesi Farmaceutici S.p.A.
Terminated - Condition: Idiopathic Pulmonary Fibrosis
Intervention: Other: GSK2634673F
Sponsor: GlaxoSmithKline
Terminated - Condition: Healthy Male Volunteers
Interventions: Drug: XPF-008; Drug: Microcrystalline Cellulose
Sponsor: Xenon Pharmaceuticals Inc.
Completed - Condition: Bronchiectasis
Interventions: Drug: GSK2793660 solution; Drug: GSK2793660 capsule; Drug: Placebo solution; Drug: Placebo capsule
Sponsor: GlaxoSmithKline
Terminated - Conditions: Visceral Leishmaniasis; Cutaneous Leishmaniases
Interventions: Drug: DNDI-0690; Drug: Placebo of DNDI-0690
Sponsor: Drugs for Neglected Diseases
Recruiting - Conditions: Optic Neuritis; Optic; Neuritis, With Demyelination
Intervention: Drug: Comparison of BN201 treatment with Placebo
Sponsors: Bionure Farma SL; Simbec Research
Completed - Condition: Dehydration Hypertonic
Interventions: Device: Patient controlled fluid device administering high volume thirst guided fluid bolus; Device: Patient controlled fluid device administering low volume thirst guided fluid bolus
Sponsors: University College, London; University of Portsmouth; University of Wollongong
Active, not recruiting - Condition: Heart Failure
Interventions: Drug: Treatment A; Drug: Treatment B; Drug: Treatment C; Drug: Treatment D
Sponsor: AstraZeneca
Completed - Condition: Human Immunodeficiency Virus
Intervention: Drug: Doravirine
Sponsors: Chelsea and Westminster NHS Foundation Trust; Merck Sharp & Dohme Corp.; Imperial College London; University of Liverpool
Not yet recruiting - Condition: Healthy, Peripheral Neuropathic Pain
Interventions: Drug: TRK-750; Drug: Placebo
Sponsor: Toray Industries, Inc
Completed - Condition: Mood and Cognitive Performance
Intervention: Dietary Supplement: Acute effect of two Saudi cultivars of date fruit on mood and cognitive performance
Sponsor: Newcastle University
Completed - Conditions: Cognitive Change; Mood Change
Interventions: Dietary Supplement: Cognivia; Dietary Supplement: Placebo
Sponsor: Northumbria University
Recruiting - Condition: IgA Nephropathy
Interventions: Drug: BION-1301 Single Dose; Drug: Placebo Single Dose; Drug: BION-1301 Multiple Doses; Drug: Placebo Multiple Doses
Sponsor: Aduro Biotech, Inc.
Recruiting - Condition: Ulcerative Colitis
Interventions: Drug: TOP1288; Drug: Placebo to TOP1288
Sponsor: Topivert Pharma Ltd
Completed - Conditions: Chronic Obstructive Pulmonary Disease; Asthma
Intervention: Drug: Beclometasone dipropionate Formoterol Fumarate Glycopyrronium Bromide
Sponsor: Chiesi Farmaceutici S.p.A.
Recruiting - Condition: Infection, Human Immunodeficiency Virus
Interventions: Drug: Cabotegravir; Drug: Rifabutin
Sponsors: ViiV Healthcare; GlaxoSmithKline
Completed - Condition: Obesity
Intervention:
Sponsor: University of Nottingham
Recruiting - Condition: Papillomavirus Infections
Interventions: Biological: AAVLP-HPV; Drug: Placebo
Sponsors: 2A Pharma AB; Celerion
Recruiting - Condition: Drug Interaction
Interventions: Drug: DS-1040b; Drug: Clopidogrel
Sponsor: Daiichi Sankyo, Inc.
Completed - A Study to Compare the Pharmacokinetics of Different Oral Formulations of FDL169 in Healthy SubjectsCondition: Cystic Fibrosis
Intervention: Drug: FDL169
Sponsor: Flatley Discovery Lab LLC
Completed - Condition: Mood Disorders
Interventions: Dietary Supplement: Proprietary, standardized botanical extract; Dietary Supplement: Placebo (maltodextrin)
Sponsors: Activ'inside; Northumbria University
Completed - Condition: Invasive Aspergillosis
Intervention: Drug: F901318
Sponsors: F2G Ltd.; Covance
Completed - Condition: Depressive Disorder
Interventions: Drug: TAK-653 Placebo; Drug: TAK-653
Sponsor: Takeda
Completed - Condition: Transthyretin-mediated Amyloidosis (ATTR Amyloidosis)
Interventions: Drug: ALN-TTRSC02; Drug: Sterile Normal Saline (0.9% NaCl)
Sponsor: Alnylam Pharmaceuticals
Completed - Condition: Smoking Cessation
Intervention: Drug: Cytisine
Sponsor: Achieve Life Sciences
Completed - Condition: Pain, Inflammatory
Interventions: Drug: GSK3858279 IV; Drug: GSK3858279 SC; Drug: Placebo matching GSK3858279 IV; Drug: Placebo matching GSK3858279 SC
Sponsor: GlaxoSmithKline
Recruiting - Condition: Venous Thromboembolism
Interventions: Drug: ONO-7684; Drug: ONO-7684 Placebo
Sponsor: Ono Pharmaceutical Co. Ltd
Recruiting - Condition: Solid Tumor
Interventions: Drug: Entrectinib 600 mg (T1); Drug: Entrectinib 600 mg (T2); Drug: Entrectinib 200 mg (R); Drug: Entrectinib 200 mg (T)
Sponsor: Genentech, Inc.
Not yet recruiting - Condition: Amyloidosis
Intervention: Drug: GSK3039294
Sponsor: GlaxoSmithKline
Terminated - Conditions: GI Glycaemic Index Healthy Volunteers; GL Glycaemic Load Healthy Volunteers
Interventions: Dietary Supplement: Birhi; Dietary Supplement: Khassab; Dietary Supplement: placebo
Sponsor: Newcastle University
Completed - Conditions: Mitochondrial Diseases; Mitochondrial Respiratory Chain Deficiencies; MELAS Syndrome; Mitochondrial Myopathies
Interventions: Drug: KL1333; Drug: Placebo Oral Tablet
Sponsor: NeuroVive Pharmaceutical AB
Recruiting - Condition: Healthy
Interventions: Drug: LY3074828; Drug: Placebo; Drug: LY900021
Sponsor: Eli Lilly and Company
Active, not recruiting - Condition: Amyloidosis
Interventions: Drug: GSK3039294; Drug: Placebo
Sponsor: GlaxoSmithKline
Withdrawn - Condition: Anaemia
Interventions: Drug: DS-1093; Drug: placebo
Sponsor: Daiichi Sankyo, Inc.
Completed - Condition: ZZ Type Alpha-1 Antitrypsin Deficiency Liver Disease
Interventions: Drug: ALN-AAT02; Drug: Placebo
Sponsor: Alnylam Pharmaceuticals
Recruiting - Condition: Adrenal Insufficiency
Interventions: Drug: Infacort®; Drug: Cortef®
Sponsors: Diurnal Limited; Simbec Research; Brush Clinical Research Ltd.; Voet Consulting; EMAS Pharma; Medical Matters International Ltd.; Nichol Pharma Services Ltd.
Completed - Condition: Malaria, Falciparum
Intervention: Drug: [14C]-GSK3191607
Sponsors: GlaxoSmithKline; Hammersmith Medicines Research
Completed - Condition: Antitrypsin Deficiency Liver Disease
Interventions: Drug: ALN-AAT; Drug: Sterile Normal Saline (0.9% NaCl)
Sponsor: Alnylam Pharmaceuticals
Terminated - Condition: Leishmaniasis
Interventions: Drug: GSK3186899; Drug: Placebo
Sponsor: GlaxoSmithKline
Recruiting - Condition: Respiratory Synctial Virus Infections
Interventions: Biological: GSK3389245A_LD GROUP; Biological: GSK3389245A_HD GROUP; Biological: Bexsero; Drug: Placebo
Sponsor: GlaxoSmithKline
Completed - Condition: Cardiovascular Diseases
Interventions: Drug: Saline 0.9%; Drug: GLP-1 7-36 amide (0.6pmol/kg/min); Drug: GLP-1 7-36 amide (1.2pmol/kg/min); Drug: Glucagon (25ng/kg/min); Drug: Glucagon (50ng/kg/min)
Sponsor: Cambridge University Hospitals NHS Foundation Trust
Recruiting - Condition: Influenza, Human
Intervention: Biological: Enzira® vaccine
Sponsor: Seqirus
Completed - Condition: Cicatrix, Hypertrophic
Interventions: Drug: OLX10010; Drug: Placebo
Sponsor: Olix Pharmaceuticals, Inc.
Recruiting - Conditions: Safety; Tolerability; Pharmacokinetics
Interventions: Drug: DS-1971; Drug: placebo
Sponsor: Daiichi Sankyo, Inc.
Completed - Condition: Menopause
Intervention: Drug: Estrogel
Sponsors: Viramal Limited; Simbec Research
Recruiting - Condition: Influenza, Human
Intervention: Biological: Trivalent Influenza Vaccine
Sponsor: Seqirus
Completed - Condition: Influenza
Intervention: Biological: Inactivated Influenza Vaccine (2009 / 2010 formulation)
Sponsor: Seqirus
Completed - Condition: Asthma
Interventions: Drug: AZD0449; Drug: Placebo
Sponsor: AstraZeneca
Recruiting - Condition: Asthma
Interventions: Drug: GSK2292767 50 μg; Drug: GSK2292767 500 μg; Drug: Placebo
Sponsor: GlaxoSmithKline
Completed - Safety, Tolerability and Pharmacokinetics of Multiple Ascending Doses of AZD8871 in Healthy SubjectsCondition: Chronic Obstructive Pulmonary Disease
Interventions: Drug: AZD8871; Drug: Placebo
Sponsors: AstraZeneca; Parexel
Completed - Condition: Hypertension, Pulmonary
Interventions: Drug: FDC (ambrisentan 10 mg-tadalafil 40 mg) single dose; Drug: Reference (ambrisentan 10 mg + tadalafil 40 mg given concurrently)
Sponsors: GlaxoSmithKline; Covance Harrogate; Hammersmith Medicines Research
Completed - Conditions: Asthma; Chronic Obstructive Pulmonary Disease
Interventions: Drug: CHF6366; Drug: Placebo CHF6366; Drug: umeclidinium bromide and vilanterol trifenatate
Sponsor: Chiesi Farmaceutici S.p.A.
Completed - Conditions: Meningococcal Meningitis, Serogroup A; Meningococcal Meningitis, Serogroup B; Meningococcal Meningitis, Serogroup C; Meningococcal Meningitis, Serogroup Y; Meningococcal Meningitis, Serogroup W
Intervention: Drug: meningococcal B vaccine & meningococcal ACYW conjugate vaccine
Sponsors: Prof. Elizabeth Miller; Novartis Vaccines
Completed - Condition: Malaria
Interventions: Biological: ChAdOx1 LS2; Biological: MVA LS2
Sponsor: University of Oxford
Completed - Condition: Healthy
Interventions: Biological: CSL730; Other: Placebo
Sponsor: CSL Behring
Recruiting - Conditions: Inflammatory Bowel Disease (IBD); Crohn's Disease (CD); Ulcerative Colitis (UC); Pregnancy
Intervention:
Sponsor: The Royal Wolverhampton Hospitals NHS Trust
Recruiting - Condition: Heart Failure
Interventions: Drug: AZD9977; Drug: Placebo
Sponsors: AstraZeneca; Parexel
Completed - Condition: Healthy Participants
Interventions: Drug: BMS-986278; Other: Placebo
Sponsor: Bristol-Myers Squibb
Active, not recruiting - Condition: Healthy
Intervention: Drug: Aramchol
Sponsors: Galmed Pharmaceuticals Ltd; Hammersmith Medicines Research; Analyst Research Laboratories; Diamond Pharma Services Regulatory Affairs Consultancy
Completed - Condition: Healthy
Interventions: Drug: Lu AF35700 5 mg clinical formulation; Drug: Lu AF35700 5 mg commercial formulation; Drug: Lu AF35700 10 mg clinical formulation; Drug: Lu AF35700 10 mg commercial formulation; Drug: Lu AF35700 20 mg clinical formulation; Drug: Lu AF35700 20 mg commercial formulation
Sponsor: H. Lundbeck A/S
Completed - Condition: Healthy
Interventions: Drug: Bupropion; Drug: ASP2151
Sponsor: Maruho Europe Limited
Completed - Condition: Healthy
Intervention: Drug: DS-1040b
Sponsors: Daiichi Sankyo, Inc.; Hammersmith Medicines Research
Completed - Condition: Healthy
Intervention:
Sponsors: University of Oxford; ReiThera Srl
Completed - Condition: Healthy
Interventions: Drug: Midazolam; Drug: ASP2151
Sponsor: Maruho Europe Limited
Completed - Condition: Crohn's Disease
Intervention: Other: Dodecanoate acid and saline
Sponsor: University of Nottingham
Completed - Condition: Healthy
Interventions: Drug: Montelukast; Drug: ASP2151
Sponsor: Maruho Europe Limited
Completed - Condition: Cardiovascular Diseases
Interventions: Other: Eligibility and lifestyle restrictions check.; Other: Medical history, demographic and lifestyle factors; Other: Anthropometric measurements: height, weight, and body fat; Other: Blood pressure and heart rate; Other: Forearm blood flow: Visit 1 (EDNRA); Other: Forearm blood flow: Visit 2 (EDNRA); Other: Blood biochemistry (PNPLA3); Other: Blood EPCR function (PROCR); Other: Blood platelet coagulation and function (PROCR); Other: Blood endothelial permeability (PROCR); Other: Blood leukocyte-endothelium adhesion (PROCR); Other: Baseline Venepuncture (PNPLA3, Visit 1); Other: Deuterium water - Loading dose 1 (PNPLA3, Visit 1); Other: Deuterium water - Loading dose 2 (PNPLA3, Visit 1); Other: Energy-balanced dinner (PNPLA3, Visit 1); Other: Fasting venepuncture (PNPLA3, Visit 2); Other: Deuterium water - Maintenance dose (PNPLA3, Visit 2); Other: Consumption of high carbohydrate meal (PNPLA3, Visit 2); Other: Postprandial Venepuncture (PNPLA3, Visit 2); Other: Venepuncture (PROCR)
Sponsors: Cambridge University Hospitals NHS Foundation Trust; University of Cambridge
Recruiting - Condition: Healthy
Interventions: Drug: ASP2151 400mg + 100mg ciclosporin; Drug: ASP2151 1200mg + 100mg ciclosporin
Sponsor: Maruho Europe Limited
Completed - Condition: Healthy
Interventions: Drug: ASP2151; Drug: ritonavir
Sponsor: Maruho Europe Limited
Completed - Condition: Healthy Male Subjects
Intervention: Drug: [14C]-Benznidazole
Sponsors: Exeltis France; Insud Pharma
Completed - Condition: Healthy Volunteers
Interventions: Drug: Evacetrapib; Drug: Pravastatin
Sponsor: Eli Lilly and Company
Completed - Condition: Heart Failure, Congestive
Interventions: Procedure: DCE-MRI scans; Other: Gadobutrol
Sponsor: GlaxoSmithKline
Completed - Condition: Malaria
Intervention: Biological: Blood-stage controlled human P. falciparum malaria infection
Sponsor: University of Oxford
Completed - Condition: Healthy Volunteers
Interventions: Drug: ivermectin T1; Drug: ivermectin T2; Drug: ivermectin T3
Sponsor: Pierre Fabre Dermatology
Withdrawn - Condition: Healthy Volunteers
Interventions: Drug: Phenoxymethyl Penicillin; Device: Microneedle array
Sponsor: Imperial College London
Active, not recruiting - Conditions: Safety; Healthy Subjects
Interventions: Drug: MEDI9314; Drug: placebo
Sponsor: MedImmune LLC
Completed - Condition: Cystic Fibrosis
Interventions: Drug: FDL169; Drug: FDL176
Sponsor: Flatley Discovery Lab LLC
Recruiting - Conditions: Cardiovascular Diseases; Chronic Kidney Disease
Interventions: Drug: Darbepoetin Alfa; Drug: Acetylcholine; Drug: Noradrenaline; Drug: BQ 123
Sponsors: Cambridge University Hospitals NHS Foundation Trust; GlaxoSmithKline
Completed - Condition: Cystic Fibrosis
Intervention: Drug: FDL176 & FDL169 coadministration
Sponsor: Flatley Discovery Lab LLC
Completed - Conditions: Retinal Disease; Retinal Degeneration; Retinal Dystrophies
Intervention: Device: Long-wavelength autofluorescence imaging
Sponsor: Oxford University Hospitals NHS Trust
Not yet recruiting - Conditions: Healthy; Nutrition Poor
Interventions: Dietary Supplement: Placebo; Dietary Supplement: Lutein
Sponsors: Kemin Foods LC; DSM Nutritional Products, Inc.
Terminated - Conditions: Aging; Cognitive Decline
Interventions: Dietary Supplement: Freeze-Dried Cranberry Powder; Dietary Supplement: Placebo
Sponsors: University of East Anglia; Clinical Research and Trials Unit (Norfolk & Norwich University Hospital, UK)
Recruiting - Condition: Group B Strep Infection
Interventions: Biological: GBS-NN/NN2 with Alhydrogel® 25; Biological: Placebo GBS-NN/NN2 with Alhydrogel® 25; Biological: Placebo GBS-NN/NN2 with Alhydrogel® 50; Biological: GBS-NN/NN2 with Alhydrogel® 50
Sponsors: Minervax ApS; Simbec Research
Active, not recruiting - Condition: Acute Ischemic Stroke
Interventions: Drug: DS-1040b; Drug: Aspirin
Sponsor: Daiichi Sankyo, Inc.
Completed - Condition: Cardiac Sarcoidosis
Interventions: Other: 18F-FDG; Drug: Prednisolone
Sponsor: University of Edinburgh
Recruiting - Condition: Respiratory Syncytial Virus Infections
Interventions: Drug: Itraconazole; Drug: Verapamil; Drug: Rifampicin; Drug: Midazolam; Drug: Placebo for RV521; Drug: RV521
Sponsor: ReViral Ltd
Completed - Conditions: Mood; Cognitive Change
Interventions: Drug: Minocycline; Other: placebo
Sponsor: University of Oxford
Completed - Condition: Smoking Cessation
Intervention: Drug: cytisine
Sponsor: Achieve Life Sciences
Completed - Condition: Frail Elderly Syndrome
Intervention: Other: resistance training
Sponsors: University of Glasgow; NHS Greater Glasgow and Clyde
Recruiting - Condition: Sleep
Interventions: Dietary Supplement: EPA-rich; Dietary Supplement: DHA-rich; Dietary Supplement: Olive oil Placebo
Sponsors: Northumbria University; BASF
Completed - Condition: Memory Consolidation
Interventions: Dietary Supplement: Olive Oil Placebo; Dietary Supplement: EPA-rich; Dietary Supplement: DHA-rich
Sponsors: Northumbria University; BASF
Completed - Condition: Diabetes Mellitus, Type 1
Interventions: Procedure: Inguinal lymph node fine needle aspirate biopsy; Procedure: Inguinal lymph node core biopsy; Procedure: Peripheral blood collection; Other: Pre- and post-biopsy questionnaire
Sponsor: GlaxoSmithKline
Completed - Condition: Cognitive Function and Mood
Intervention: Other: Herbal Beverage
Sponsors: PepsiCo Global R&D; Northumbria University
Completed - Condition: Healthy
Interventions: Drug: JNJ-64179375 0.3 mg/kg; Drug: JNJ-64179375 1.0 mg/kg; Drug: JNJ-64179375 2.5 mg/kg; Other: Placebo; Drug: JNJ-64179375 (Dose to be Determined)
Sponsor: Janssen Research & Development, LLC
Completed - Condition: Metabolic Disease
Interventions: Drug: PXL770; Drug: Placebo; Drug: Rosuvastatin
Sponsor: Poxel SA
Completed - Condition: Cystic Fibrosis
Intervention: Drug: FDL169
Sponsor: Flatley Discovery Lab LLC
Completed - Conditions: Pleasant Touch; Cortical Response
Intervention:
Sponsors: University College Cork; University College London - Institute of Child Health (UCL-ICH); Science Foundation Ireland; Johnson & Johnson Ltd.
Recruiting - Condition: Cognitive Change
Interventions: Dietary Supplement: Zanthozylum armatum; Dietary Supplement: Placebo
Sponsors: Northumbria University; Mibelle AG
Completed - Condition: Scarring
Interventions: Procedure: Incision; Drug: Active gel; Drug: Placebo gel
Sponsors: University Hospitals, Leicester; Leicester Clinical Trials Unit; University of Leicester; Medical Research Council
Active, not recruiting - Condition: Cognitive Function
Intervention: Other: Phenolic Beverage
Sponsors: PepsiCo Global R&D; Northumbria University
Completed - Condition: Epilepsy
Intervention: Drug: sodium valproate
Sponsor: Sanofi
Completed - Condition: Cystic Fibrosis
Intervention: Other: Hyperpolarized Xenon MRI
Sponsors: Papworth Hospital NHS Foundation Trust; University of Sheffield
Suspended - Condition: Asthma
Interventions: Drug: Seretide 250(8puffs) via Evohaler actuator; Drug: Seretide 250 (8 puffs)/placebo via Volumatic spacer; Drug: Seretide 250/placebo 8 puffs via Aerochamber Plus spacer; Drug: Seretide 250/placebo via Synchro-Breathe
Sponsor: Brian J Lipworth
Completed - Conditions: Healthy; Overweight and Obesity
Interventions: Dietary Supplement: Blood orange juice; Dietary Supplement: Control drink
Sponsor: University of Leeds
Active, not recruiting - Condition: Malaria, Vivax
Interventions: Other: Plasmodium vivax infection; Procedure: Collection of 250mL blood from each volunteer (N=2)
Sponsor: University of Oxford
Active, not recruiting - Condition: Healthy
Interventions: Other: Tomato, onion and lovage soup (TOL); Other: TOL soup with inulin
Sponsors: University of Glasgow; Scottish Universities Environmental Research Centre
Recruiting - Condition: Stroke
Intervention:
Sponsors: University of Nottingham; The Dunhill Medical Trust
Recruiting - Condition: Healthy
Intervention: Dietary Supplement: Cherry versus placebo concentrate
Sponsor: University of Exeter
Completed - Condition: Healthy
Intervention: Other: Saliva Sample Collection
Sponsors: Quadram Institute Bioscience; GlaxoSmithKline
Completed - Conditions: Anorexia Nervosa in Remission; Eating Disorder
Intervention: Other: Volatility task
Sponsor: University of Oxford
Completed - Conditions: Cycloserine; Healthy Volunteer
Interventions: Drug: d-cycloserine; Drug: Placebo
Sponsor: University of Oxford
Completed - Condition: Osteoarthritis, Knee
Interventions: Other: Ice Pack and Cooling Device; Drug: CNTX-4975-05 (trans-capsaicin); Drug: Capsaicin
Sponsor: Centrexion Therapeutics
Completed - Condition: Tuberculosis
Interventions: Biological: BCG; Other: Saline placebo
Sponsors: University of Oxford; University of Birmingham
Unknown status - Condition: Healthy
Intervention: Drug: DS-1971a
Sponsor: Daiichi Sankyo, Inc.
Completed - Condition: Meningococcal Disease
Interventions: Biological: Meningococcal (group B) multicomponent recombinant adsorbed vaccine.; Biological: Meningococcal (group B) multicomponent recombinant adsorbed vaccine, without Outer Membrane Vesicles (OMV)
Sponsor: Novartis Vaccines
Completed - Condition: Chronic Obstructive Pulmonary Disease (COPD)
Intervention:
Sponsors: Pneumacare Ltd; Cambridge University Hospitals NHS Foundation Trust
Recruiting - Condition: Atopic Dermatitis
Interventions: Drug: ZPL-5212372 1% w/w Ointment BID; Drug: Placebo Ointment BID
Sponsor: Ziarco Pharma Ltd
Completed - Conditions: Male Infertility; Obesity; Weight Loss
Interventions: Dietary Supplement: Low Energy Diet; Other: NHS advice on healthy eating
Sponsor: Imperial College London
Recruiting - Conditions: Meningitis, Bacterial; Neisseria Infection
Intervention: Biological: N. lactamica
Sponsors: University of Southampton; University Hospital Southampton NHS Foundation Trust
Recruiting - Condition: Healthy Participants
Intervention: Drug: BMS-986205
Sponsor: Bristol-Myers Squibb
Completed - Conditions: Hepatitis C Infection; HIV Infection
Interventions: Biological: AdCh3NSmut1; Biological: MVA-NSmut; Biological: ChAdV63.HIVconsv; Biological: MVA.HIVconsv
Sponsors: University of Oxford; ReiThera Srl; GlaxoSmithKline
Completed - Condition: Healthy Volunteers
Interventions: Dietary Supplement: Palm olein; Dietary Supplement: Interesterified palm olein; Dietary Supplement: soybean oil
Sponsors: Imperial College London; Malaysia Palm Oil Board
Completed - Condition: Smoking Cessation
Intervention: Drug: Cytisine
Sponsor: Achieve Life Sciences
Terminated - Condition: Healthy
Interventions: Other: Treatment; Other: Comparator
Sponsors: Unilever R&D; University of Bristol Dental Hospital
Completed - Condition: Healthy Volunteer
Intervention: Drug: lomitapide
Sponsors: Aegerion Pharmaceuticals, Inc.; Richmond Pharmacology Limited
Completed - Condition: Healthy Adults
Interventions: Dietary Supplement: Tomato, onion & lovage soup with inulin; Dietary Supplement: Tomato, onion & lovage soup; Dietary Supplement: Inulin
Sponsors: University of Glasgow; Scottish Universities Environmental Research Centre
Completed - Condition: Urologic Diseases
Interventions: Drug: Commercially available combination of dutasteride 0.5 mg and tamsulosin HCL 0.4 mg; Drug: Second generation dutasteride 0.5 mg and tamsulosin HCL 0.4 mg combination capsule
Sponsor: GlaxoSmithKline
Completed - Condition: Healthy Aging
Interventions: Other: Grammatical Reasoning; Other: Card Pairs
Sponsors: University of Exeter; South London and Maudsley NHS Foundation Trust; King's College London; Wesnes Cognition Ltd
Completed - Condition: Healthy
Interventions: Dietary Supplement: Single dose fish oil; Dietary Supplement: Repeated dose fish oil; Dietary Supplement: single dose Camelina seed oil; Dietary Supplement: repeated dose camelina seed oil
Sponsor: University of Southampton
Recruiting - Condition: Respiratory Syncytial Virus (RSV)
Intervention: Diagnostic Test: RSV point of care testing
Sponsors: University of Oxford; Innovative Medicines Initiative; Respiratory syncytial virus consortium in Europe
Recruiting - Condition: Healthy Volunteers
Intervention: Other: Hyperpolarised Xenon
Sponsor: Sheffield Teaching Hospitals NHS Foundation Trust
Recruiting - Condition: Healthy Volunteers
Intervention: Other: polarised 3 helium
Sponsors: Sheffield Teaching Hospitals NHS Foundation Trust; University of Sheffield
Recruiting - Condition: Pulmonary Disease, Chronic Obstructive
Interventions: Drug: [14C]-GSK2269557 IV infusion; Drug: GSK2269557 via DPI; Drug: [14C]-GSK2269557 oral solution
Sponsor: GlaxoSmithKline
Completed - Conditions: Drug Drug Interaction; Autoimmune Diseases; Fibrotic Disease
Interventions: Drug: KD025; Drug: Itraconazole; Drug: Rabeprazole; Drug: Rifampicin; Drug: Omeprazole
Sponsors: Kadmon Corporation, LLC; Quotient Sciences
Recruiting - Condition: Diabetes Mellitus, Type 1
Intervention: Procedure: two step hyperinsulinaemic glucose clamp study.
Sponsor: The Royal Bournemouth Hospital
Terminated - Conditions: Lung Inflammation; Sarcoidosis
Interventions: Radiation: PET/CT scan; Other: LPS Challenge; Other: Saline Challenge; Diagnostic Test: Blood and urine sampling
Sponsors: Cambridge University Hospitals NHS Foundation Trust; GlaxoSmithKline
Recruiting - Condition: Urologic Diseases
Interventions: Drug: Commercially available combination of dutasteride 0.5 mg and tamsulosin HCL 0.4 mg; Drug: Second generation dutasteride 0.5 mg and tamsulosin HCL 0.4 mg combination capsule
Sponsor: GlaxoSmithKline
Completed - Conditions: Eating Behavior; Obesity
Interventions: Drug: mCPP; Drug: Placebo oral tablet
Sponsors: University of Birmingham; University Hospital Birmingham
Recruiting - Conditions: Eating Disorder; Healthy
Interventions: Behavioral: Food specific Inhibitory control training; Behavioral: Implementation intentions; Behavioral: General inhibitory control training
Sponsors: King's College London; University of Exeter
Recruiting - Condition: Inflammatory Bowel Diseases
Interventions: Drug: GSK2983559; Drug: Placebo
Sponsor: GlaxoSmithKline
Recruiting - Condition: Asthma
Interventions: Device: VENTOLIN Mini-Spacer; Device: Aerochamber Plus spacer
Sponsor: GlaxoSmithKline
Completed - Condition: HIV Infections
Interventions: Drug: GSK3640254 bis-hydrochloride salt capsule; Drug: GSK3640254 Mesylate Salt Capsule
Sponsor: ViiV Healthcare
Completed - Conditions: Ischemic Cardiomyopathy; Dilated Cardiomyopathy; Hypertrophic Cardiomyopathy
Intervention: Other: Mangafodipir trisodium
Sponsor: University of Edinburgh
Recruiting - Condition: Cytochrome P450 Interaction
Interventions: Drug: Lu AF35700; Drug: Itraconazole (200 mg); Drug: Itraconazole (300 mg)
Sponsor: H. Lundbeck A/S
Recruiting - Condition: Asthma
Intervention: Drug: AZD1402
Sponsor: AstraZeneca
Recruiting - Condition: Constipation
Intervention: Device: MiniCap
Sponsors: Nottingham University Hospitals NHS Trust; University of Nottingham
Recruiting - Condition: Therapeutic Equivalency
Intervention: Drug: Azathioprine
Sponsors: Nova Laboratories Limited; Medicines Evaluation Unit Ltd; Syne Qua Non Limited; Alderley Analytical Ltd; Black County Pathology Services; Diamond Pharma Services Regulatory Affairs Consultancy; Boyd Consultants
Recruiting - Conditions: Memory; Learning
Interventions: Drug: Losartan Potassium; Other: placebo
Sponsor: University of Oxford
Completed - Condition: Autoimmune Diseases
Interventions: Drug: GSK2982772 Modified Release (MR); Drug: GSK2982772 Immediate Release (IR)
Sponsors: GlaxoSmithKline; Quotient Clinical
Completed - Condition: Asthma
Interventions: Drug: TD-8236 (for SAD); Drug: TD-8236 (for MAD); Drug: Placebo (for SAD); Drug: Placebo (for MAD)
Sponsor: Theravance Biopharma
Recruiting - Conditions: Streptococcus Pneumoniae Infection; Streptococcus Pneumoniae, Invasive Disease; Streptococcal Pneumonia
Interventions: Diagnostic Test: Nasopharyngeal swab; Diagnostic Test: blood sampling
Sponsors: University of Oxford; Pfizer
Recruiting - Condition: Rumination
Interventions: Behavioral: Diaphragmatic breathing; Behavioral: Deep Slow Breathing; Behavioral: Normal breathing
Sponsor: Queen Mary University of London
Not yet recruiting - Condition: Topical Anaesthesia
Interventions: Device: Microneedle Patch; Device: Patch with no microneedles
Sponsor: Innoture Ltd
Completed - Condition: Cognitive Change
Interventions: Dietary Supplement: Lactobacillus paracasei Lpc-37; Dietary Supplement: Placebo
Sponsors: Northumbria University; DuPont Nutrition and Health
Recruiting - Condition: Postoperative Nausea and Vomiting
Interventions: Drug: APD421; Drug: Placebo; Drug: Ondansetron
Sponsor: Acacia Pharma Ltd
Completed - Condition: Pain
Interventions: Drug: OLP-1002; Other: Placebo
Sponsor: OliPass Corporation
Recruiting - Condition: Bioequivalence
Interventions: Drug: Imeglimin Reference product; Drug: Imeglimin
Sponsor: Poxel SA
Completed - Condition: Pharmacokinetics
Interventions: Drug: Padsevonil (UCB0942); Drug: Erythromycin
Sponsor: UCB Biopharma S.P.R.L.
Completed - Condition: Dyslipidemias
Interventions: Drug: NST-4016 600mg; Drug: Placebo oral capsule; Drug: Moxifloxacin 400mg; Drug: NST-4016 2000mg
Sponsor: NorthSea Therapeutics B.V.
Completed - Condition: Filariasis
Intervention: Drug: LSF emodepside (BAY 44-4400) oral solution (1mg/mL)
Sponsors: Drugs for Neglected Diseases; Bayer; Bill and Melinda Gates Foundation
Completed - Conditions: Dietary Modification; Dietary Habits
Interventions: Behavioral: Personalised advice; Behavioral: Non-personalised advice
Sponsor: University of Reading
Completed - Condition: Autism Spectrum Disorder
Interventions: Drug: RO7017773; Other: [11C] Ro15-4513
Sponsor: Hoffmann-La Roche
Completed - Condition: Diabetes Mellitus
Intervention: Device: Microprobe glucose sensor
Sponsor: Imperial College London
Completed - Condition: Parkinson Disease
Interventions: Drug: Ongentys; Drug: BIA 9-1067 (test)
Sponsor: Bial - Portela C S.A.
Not yet recruiting - Condition: Influenza in Humans
Interventions: Drug: AL-794; Drug: Oseltamivir; Drug: Digoxin; Drug: Midazolam; Drug: Pitavastatin; Drug: JNJ-63623872
Sponsor: Alios Biopharma Inc.
Completed - Condition: MERS (Middle East Respiratory Syndrome)
Intervention: Biological: ChAdOx1 MERS
Sponsor: University of Oxford
Recruiting - Effects of a Single Day of Mixed Macronutrient Overfeeding on Energy Balance and Metabolic ResponsesConditions: Metabolic Disease; Appetitive Behavior
Interventions: Other: Overfeed; Other: Energy Balance
Sponsor: Leeds Beckett University
Completed - Conditions: Asthma; Chronic Obstructive Pulmonary Disease
Interventions: Drug: Therapeutic Dose 1; Drug: Therapeutic Dose 2; Drug: Supra-therapeutic Dose; Drug: Placebo
Sponsor: Chiesi Farmaceutici S.p.A.
Recruiting - Condition: Acceptance, Social
Intervention: Dietary Supplement: Biscuit acceptance
Sponsors: Newcastle University; University of Aberdeen; University of Bristol; University of Liverpool
Not yet recruiting - Condition: Infections, Upper Respiratory Tract
Interventions: Dietary Supplement: Probiotic strain; Dietary Supplement: Placebo
Sponsors: Chr Hansen; Onorach Clinical; CPS Research
Active, not recruiting - Condition: Diet Modification
Interventions: Behavioral: Mindful eating; Behavioral: Eating without distractions
Sponsor: City, University of London
Recruiting - Condition: Common Cold
Interventions: Device: ColdZyme® mouth spray; Device: Placebo
Sponsor: Enzymatica AB
Completed - Condition: Meningitis, Bacterial
Interventions: Biological: N. lactamica; Other: PBS only
Sponsors: University of Southampton; University Hospital Southampton NHS Foundation Trust
Recruiting - Condition: Respiratory Syncytial Virus Infections
Interventions: Drug: Placebo; Drug: JNJ-53718678
Sponsor: Janssen Sciences Ireland UC
Completed - Condition: Anaemia
Interventions: Drug: [14C]-GSK1278863 solution for IV infusion; Drug: [14C]-GSK1278863 oral solution; Drug: Daprodustat 6 mg oral tablet
Sponsor: GlaxoSmithKline
Completed - Conditions: Cigarette Smoking; Coronary Heart Disease; Cardiovascular Risk Factor; Insulin Resistance; Oxidative Stress; Inflammation
Intervention: Behavioral: Exercise
Sponsors: Loughborough University; University of Leicester; University Hospitals, Leicester
Completed - Condition: Opioid-use Disorder
Interventions: Drug: INDV-6200; Drug: Placebo; Drug: SL Buprenorphine; Drug: Nalorex
Sponsor: Indivior Inc.
Completed - Condition: Non-alcoholic Fatty Liver Disease
Intervention: Device: Breath analysis - electronic signature "Breath-print"
Sponsors: University of Edinburgh; University of Strathclyde; University of Amsterdam
Completed - Condition: Malaria
Interventions: Biological: ChAd63-METRAP; Biological: MVA ME-TRAP
Sponsor: University of Oxford
Recruiting - Conditions: Blood Pressure; Sports Physical Therapy
Intervention: Other: Exercise
Sponsor: University of Plymouth
Completed - Condition: Muscle Disuse Atrophy
Intervention: Procedure: Eccentric exercise
Sponsor: University of Exeter
Recruiting - Condition: Influenza
Interventions: Biological: adjuvanted FLU-v; Biological: adjuvanted placebo; Other: Influenza challenge
Sponsors: PepTcell Limited; National Institute of Allergy and Infectious Diseases (NIAID)
Completed - Condition: Cough
Interventions: Other: Induction of cough with inhaled citric acid; Procedure: Peptest™ analysis of saliva pepsin; Diagnostic Test: Peptest™
Sponsor: Hull and East Yorkshire Hospitals NHS Trust
Completed - Condition: Cardiovascular Disease
Intervention: Drug: [14C]AZD5718 Oral Suspension
Sponsors: AstraZeneca; Quotient Sciences
Recruiting - Condition: Invasive Aspergillosis
Interventions: Drug: IV F901318; Drug: Oral F901318
Sponsors: F2G Ltd.; Quotient Clinical
Not yet recruiting - Conditions: Cardiovascular Disease+Pulmonary Disease; Pulmonary Arterial Hypertension
Interventions: Drug: BIA 5-1058; Drug: Placebo
Sponsor: Bial - Portela C S.A.
Recruiting - Condition: Hearing Loss
Interventions: Other: Ultrasonic noise exposure; Diagnostic Test: Pure Tone Audiometry
Sponsors: Ultrahaptics Ltd; Avon Partnership NHS
Completed - Condition: HIV Infections
Interventions: Drug: Dolutegravir dispersible tablet; Drug: Dolutegravir oral suspension; Drug: Dolutegravir oral solution
Sponsor: ViiV Healthcare
Not yet recruiting - Conditions: Typhoid Fever; Enteric Fever; Typhoid
Interventions: Biological: Vaccine placebo (excipients only); Biological: Ty21a; Biological: M10ZH09 vaccine
Sponsors: University of Oxford; Wellcome Trust; Imperial College London; University of Maryland
Active, not recruiting - Conditions: Emotions; Motivation; Reward; Dopamine
Interventions: Drug: Pramipexole; Drug: Placebo
Sponsor: University of Oxford
Recruiting - Condition: Endometriosis
Interventions: Drug: Placebo; Drug: FOR-6219
Sponsors: Forendo Pharma Ltd; Richmond Pharmacology Limited
Recruiting - Conditions: Cardiovascular Diseases; Inflammation; Inflammation; Skin; Inflammatory Response; Nitric Oxide
Interventions: Dietary Supplement: Nitrate-rich Beetroot Juice; Dietary Supplement: Nitrate-deplete Beetroot Juice
Sponsor: Queen Mary University of London
Recruiting - Conditions: Atherosclerosis; Diabetes; Coronary Artery Disease
Intervention: Device: diffuse optical tomography
Sponsors: Sheffield Teaching Hospitals NHS Foundation Trust; University of Sheffield
Recruiting - Condition: Malaria
Interventions: Biological: R21 with Matrix-M1; Biological: ChAd63 ME-TRAP; Biological: MVA ME-TRAP
Sponsor: University of Oxford
Completed - Conditions: Cognitive Function and Mood; Cerebral Blood Flow; Systemic Inflammation; Gut Microbiota; Overweight and Obesity
Interventions: Dietary Supplement: Resveratrol; Dietary Supplement: Placebo
Sponsors: Northumbria University; Evolva SA
Recruiting - Condition: Anesthesia
Intervention: Device: shear wave elastography
Sponsor: University of Dundee
Completed - Conditions: Obstructive Sleep Apnoea; Inflammation
Intervention:
Sponsors: King's College London; Guy's and St Thomas' NHS Foundation Trust
Recruiting - Condition: Arthritis, Rheumatoid
Interventions: Drug: Placebo; Drug: GSK3358699; Biological: GM-CSF; Biological: LPS; Other: Cantharidin
Sponsor: GlaxoSmithKline
Recruiting - Condition: Pulmonary Disease, Chronic Obstructive
Interventions: Drug: BGF MDI (budesonide, glycopyrronium and formoterol fumarate) with 10 s breath hold; Drug: BGF MDI ((budesonide, glycopyrronium and formoterol fumarate) with 3 s breath hold
Sponsor: AstraZeneca
Completed - Condition: Healthy
Interventions: Other: Freeze dried blueberry powder; Other: Anthocyanin free, sugar-matched placebo
Sponsor: University of East Anglia
Not yet recruiting - Condition: Healthy
Interventions: Dietary Supplement: Prebiotic (Synergy-1) + Iron supplement; Dietary Supplement: Placebo (Maltodextrin) + Iron Supplement
Sponsors: Gemma Walton; Biotechnology and Biological Sciences Research Council
Recruiting - Condition: Asthma
Intervention:
Sponsors: Pneumacare Ltd; Cambridge University Hospitals NHS Foundation Trust; University Hospitals of North Midlands NHS Trust; Keele University
Completed - Conditions: Feeding Behavior; Gastrointestinal Microbiome; Diet; Meal Time
Interventions: Other: Large Lunch Intervention; Other: Large Dinner Intervention
Sponsor: University of Glasgow
Completed - Condition: Healthy
Interventions: Dietary Supplement: Beta-alanine; Dietary Supplement: Placebo
Sponsor: University of Exeter
Recruiting - Condition: Healthy
Interventions: Dietary Supplement: Low nucleotide; Dietary Supplement: High nucleotide; Dietary Supplement: High nucletide + Ribose
Sponsor: University of Exeter
Recruiting - Conditions: Health, Subjective; Healthy; Microbial Colonization
Intervention: Dietary Supplement: Fermented whey concentrate
Sponsors: University of Aberdeen; A. Vogel
Recruiting - Condition: Healthy
Interventions: Other: Low nucleotide meal; Other: High nucleotide meal
Sponsor: University of Exeter
Completed - Condition: Influenza
Intervention: Biological: MF59 - ATIV
Sponsors: University of Oxford; Emory University; VisMederi srl
Active, not recruiting - Conditions: Bioavailability; Cardiovascular Health Status
Intervention: Other: Coffee
Sponsor: University of Leeds
Completed - Condition: Healthy
Interventions: Dietary Supplement: Hypotonic; Dietary Supplement: Isotonic; Dietary Supplement: Placebo; Other: Dehydrated
Sponsor: University of Exeter
Completed - Condition: Shigella Infection
Intervention: Biological: SC599
Sponsor: Institut Pasteur
Completed - Condition: Healthy
Interventions: Other: Caffeine powder -60; Other: Caffeine powder -30; Other: Caffeine powder 0; Other: Placebo powder -60; Other: Placebo powder -30; Other: Placebo powder 0
Sponsor: University of Exeter
Completed - Condition: Healthy
Interventions: Other: Mycoprotein beverage; Other: Milk protein beverage
Sponsor: University of Exeter
Active, not recruiting - Condition: Healthy
Interventions: Dietary Supplement: Post exercise protein-polyphenol supplement; Dietary Supplement: Post exercise placebo supplement; Dietary Supplement: Pre bed protein-polyphenol supplement; Dietary Supplement: Pre bed placebo supplement
Sponsor: University of Exeter
Completed - Condition: Autoimmune Diseases
Interventions: Drug: GSK2982772 MR1 formulation; Drug: GSK2982772 MR2 formulation; Drug: GSK2982772 IR formulation; Drug: GSK2982772 MR3 formulation; Drug: GSK2982772 MR4 formulation; Drug: GSK2982772 MRX-1; Drug: GSK2982772 MRX-2
Sponsors: GlaxoSmithKline; Quotient Sciences
Recruiting - Conditions: BCG Infection; Reaction - Vaccine; Immune Response
Interventions: Biological: BCG, NeisVac‐C®, Pediacel®, Infanrix™, Prevenar‐13®, Menitorix®, Priorix®, Rotarix®; Biological: NeisVac‐C®, Pediacel®, Infanrix™, Prevenar‐13®, Menitorix®, Priorix®, Rotarix®
Sponsor: University of Oxford
Completed - Condition: Enteric Fever Caused by Salmonella Enterica Serovar Paratyphi A
Intervention: Biological: Salmonella enterica serovar Paratyphi A (strain NVGH308)
Sponsor: University of Oxford
Active, not recruiting - Condition: Healthy
Interventions: Drug: DS-1971a suspension; Drug: DS-1971a tablet
Sponsor: Daiichi Sankyo, Inc.
Completed - Condition: Crohn Disease
Interventions: Diagnostic Test: Muscle strength and fatigue assessment; Diagnostic Test: Dual-energy X-ray absorptiometry (DEXA scan); Diagnostic Test: Supine cardiorespiratory fitness assessment; Diagnostic Test: fMRI Exercise assessment; Diagnostic Test: Muscle deconditioning assessment
Sponsor: University of Nottingham
Recruiting - Condition: Influenza
Interventions: Drug: CS-8958 formulated as dry powder; Other: Placebo
Sponsors: Biota Scientific Management Pty Ltd; National Institute of Allergy and Infectious Diseases (NIAID)
Completed - Conditions: Gastric Cancer; Esophageal Cancer; Renal Cancer; Prostate Cancer; Bladder Cancer; Pancreatic Cancer
Interventions: Device: ReCIVA; Device: CASPER
Sponsors: Owlstone Ltd; Cambridge University Hospitals NHS Foundation Trust; Cancer Research UK
Recruiting - Condition: Malaria, Vivax
Intervention: Biological: P. vivax infected inoculum (parasitised red blood cells)
Sponsor: University of Oxford
Recruiting - Condition: Healthy Volunteers
Interventions: Drug: Treatment A (Budesonide/Albuterol Sulfate metered dose inhaler); Drug: Treatment B (Budesonide metered dose inhaler); Drug: Treatment C (Albuterol Sulfate metered dose inhaler)
Sponsor: AstraZeneca
Completed - Condition: Healthy Ageing
Interventions: Dietary Supplement: polyphenol rich chocolate bar; Dietary Supplement: polyphenol rich cocoa powder; Dietary Supplement: low polyphenol content chocolate bar; Dietary Supplement: low polyphenol content cocoa powder
Sponsor: Queen Margaret University
Active, not recruiting - Condition: Healthy Overweight
Intervention: Other: raspberry powder, milled flaxseed and soy milk
Sponsors: King's College London; The National Processed Raspberry Council
Recruiting - Condition: Healthy
Interventions: Dietary Supplement: 50ug selenium enriched yeast; Dietary Supplement: 100ug selenium enriched yeast; Dietary Supplement: 200ug selenium enriched yeast; Dietary Supplement: Control onion; Dietary Supplement: Enriched onion; Other: Placebo
Sponsors: Quadram Institute Bioscience; Food Standards Agency, United Kingdom
Completed - Condition: Healthy Volunteers
Interventions: Drug: Afolia; Drug: US Gonal-f®
Sponsor: Fertility Biotech AG
Completed - Condition: Functional Neurological Disorders
Intervention: Other: Behavioural study
Sponsor: University College, London
Recruiting - Conditions: Lipids; Lipid Metabolism; Healthy
Interventions: Other: High SFA diet (Diet 1); Other: Low SFA diet (Diet 2)
Sponsors: University of Surrey; University of Reading; Imperial College London
Recruiting - Condition: Psoriasis
Interventions: Biological: GSK2831781; Biological: Placebo
Sponsors: GlaxoSmithKline; Parexel
Completed - Condition: Malaria
Intervention: Biological: RH5.1/ ASO1
Sponsor: University of Oxford
Recruiting - Condition: Mitochondrial Diseases
Intervention:
Sponsors: Newcastle University; Newcastle-upon-Tyne Hospitals NHS Trust
Recruiting - Condition: Chronic Kidney Disease Mineral and Bone Disorder
Intervention: Diagnostic Test: Collection of blood, urine and stool samples
Sponsors: Great Ormond Street Hospital for Children NHS Foundation Trust; University of Kiel; Athens General Children's Hospital "Pan. & Aglaia Kyriakou"; Hannover Medical School; University Hospital Heidelberg; Cukurova University
Recruiting - Condition: Haemophilia
Interventions: Diagnostic Test: Thrombophilia screen; Diagnostic Test: Initiation pathway analysis
Sponsor: Royal Free Hospital NHS Foundation Trust
Recruiting - Condition: Cardiorespiratory Fitness
Intervention: Behavioral: HIIT
Sponsor: University of Nottingham
Completed - Condition: Stroke
Intervention: Diagnostic Test: Transcranial Doppler Ultrasound
Sponsor: University of Edinburgh
Completed - Condition: Cardiac Amyloidosis
Intervention: Other: 18F-NaF PET
Sponsor: University of Edinburgh
Recruiting - Condition: Multiple Sclerosis
Interventions: Device: Magnetic Resonance Imaging; Drug: Prohance (Gadoteridol)
Sponsor: University of Nottingham
Recruiting - Conditions: Celiac Disease; Coeliac Disease; Celiac Sprue; Gluten Enteropathy
Intervention: Other: Gluten free diet
Sponsors: University of Nottingham; Nottingham University Hospitals NHS Trust; University of Salerno
Active, not recruiting - Condition: Streptococcus Pneumoniae
Intervention:
Sponsor: Prof. Elizabeth Miller
Completed - Condition: Atherosclerosis
Interventions: Dietary Supplement: Mixed High Fat Diet; Dietary Supplement: Saturated fat diet; Dietary Supplement: Monounsaturated fat diet; Dietary Supplement: Polyunsaturated fat diet; Dietary Supplement: Triolein 13C; Dietary Supplement: Low fat
Sponsor: Imperial College London
Terminated - Conditions: Metabolic Syndrome; Insulin Sensitivity
Interventions: Dietary Supplement: Seaweed extract; Dietary Supplement: Placebo
Sponsors: BioAtlantis Ltd.; University of Roehampton
Active, not recruiting - Conditions: Healthy Volunteers; Biotin Excretion
Intervention: Dietary Supplement: Biotin
Sponsor: SPD Development Company Limited
Completed - Condition: Vitamin D Deficiency
Interventions: Radiation: DEXA; Radiation: pQCT; Other: Lifestyle Questionnaire; Other: Aerobic Fitness; Other: Muscular Strength; Biological: Blood draw and finger prick test; Other: Muscular Power
Sponsor: University of Surrey
Completed - Conditions: Bronchomalacia; Asthma; Lung Neoplasms; Lung Diseases, Interstitial; Pulmonary Disease, Chronic Obstructive
Interventions: Other: Lung sound transmission measurement; Other: Lung sound recording
Sponsors: Maximilian Nussbaumer; Cambridge University Hospitals NHS Foundation Trust
Recruiting - Conditions: Primary Sclerosing Cholangitis; Primary Biliary Cirrhosis; Gallstones; Liver Diseases
Intervention: Device: MRCP+
Sponsor: Perspectum Diagnostics Ltd
Active, not recruiting - Conditions: Mindfulness; Healthy Population
Interventions: Behavioral: 20 minutes of mindfulness practice; Behavioral: 5 minutes of mindfulness practice; Other: 5 minute audio book; Other: 20 minute audio book; Other: 25 minute audio book
Sponsor: Canterbury Christ Church University
Not yet recruiting - Conditions: Head and Neck Cancer; Radiotherapy Side Effect
Intervention:
Sponsor: King's College London
Recruiting - Condition: Peripheral Arterial Disease
Interventions: Device: Active Intermittent Negative Pressure (INP); Device: Placebo Intermittent Negative Pressure (INP)
Sponsor: University of Dundee
Recruiting - Conditions: Cardiovascular Diseases; Vascular Diseases; Hypertension
Interventions: Other: Brief lifestyle/medical history questionnaire; Other: Anthropometric measures; Other: Blood pressure and arterial stiffness; Other: Cardiac output and lung function; Other: Heart rate variability; Other: Blood sample & spot urine sample; Other: 24 hour ambulatory blood pressure monitor; Other: 24 hour urine collection; Other: Echocardiograph: Left ventricular mass; Other: Large artery structure: Carotid intima-media thickness; Other: Small artery structure: Minimum forearm vascular resistance; Other: Large artery endothelial function; Other: Small artery endothelial function: Forearm blood flow; Other: Dundee step test; Other: Detailed haemodynamic response to submaximal exercise; Other: Cardiopulmonary fitness: Maximum oxygen consumption; Other: Haemodynamic response to mental stress
Sponsors: Cambridge University Hospitals NHS Foundation Trust; University of Cambridge
Recruiting - Condition: Effect of Food on Postprandial Hyperglycemia
Interventions: Other: control; Other: test meal 1; Other: test meal 2; Other: test meal 3
Sponsor: University of Leeds
Completed - Condition: Adrenal Insufficiency
Intervention:
Sponsors: Imperial College London; National Institute for Health Research, United Kingdom
Recruiting - Condition: Hyperglycemia
Interventions: Dietary Supplement: Study nutritional drink; Dietary Supplement: Standard nutritional drink
Sponsors: University of Southampton; National University Hospital, Singapore; Auckland UniServices Ltd.; Singapore Institute for Clinical Sciences; National University, Singapore; Nestec Ltd.
Active, not recruiting - Condition: High Intensity Interval Training
Interventions: Other: High intensity interval training; Other: Moderate intensity continuous training
Sponsors: University of Central Lancashire; University of Hull
Completed - Condition: Patient Specific Computational Modeling
Interventions: Other: Motion capture; Diagnostic Test: MR scan; Diagnostic Test: CT scan
Sponsor: University of Southampton
Completed - Condition: Antipsychotic-induced Weight Gain
Interventions: Drug: Olanzapine; Drug: CORT118335; Drug: Placebo
Sponsor: Corcept Therapeutics
Not yet recruiting - Condition: Osteoporosis
Interventions: Device: Strain Gauge; Other: Vibration therapy
Sponsors: Sheffield Teaching Hospitals NHS Foundation Trust; University of Sheffield
Completed - Conditions: Sarcoidosis; Sarcoidosis, Pulmonary; ILD; Interstitial Lung Disease
Intervention: Diagnostic Test: Exercise
Sponsor: Kingston University
Completed - Condition: Obesity
Intervention: Dietary Supplement: Cellodextrin
Sponsors: University of Nottingham; Biotechnology and Biological Sciences Research Council
Active, not recruiting - Condition: Hypertrophy
Interventions: Dietary Supplement: Placebo beverage; Dietary Supplement: Protein-polyphenol beverage
Sponsor: University of Exeter
Recruiting - Safety, Tolerability and Long-term Immunogenicity of Different Formulations of a Chikungunya VaccineCondition: Chikungunya Virus Infection
Interventions: Biological: MV-CHIK lyophilised formulation, low dose; Biological: MV-CHIK liquid frozen formulation, low dose; Biological: MV-CHIK SPS® formulation, low dose; Biological: MV-CHIK liquid frozen formulation, high dose; Biological: MV-CHIK liquid frozen formulation, high dose and placebo
Sponsor: Themis Bioscience GmbH
Recruiting - Condition: Cognitive Function
Interventions: Dietary Supplement: 3 g PronovaPure 150:500 EE EU; Dietary Supplement: 3 g PronovaPure 500:200 EE EU; Dietary Supplement: 3 g Placebo
Sponsors: Northumbria University; Pronova BioPharma
Completed - Conditions: Dietary Modification; Dietary Habits
Interventions: Behavioral: Non-personalised advice; Behavioral: Online personalised advice; Behavioral: Face-to-face personalised advice
Sponsor: University of Reading
Completed - Condition: IBD
Intervention: Drug: Alicaforsen
Sponsor: Atlantic Pharmaceuticals Ltd
Completed - Condition: Obesity
Interventions: Dietary Supplement: Natural high potency sweetener from leaf extract; Dietary Supplement: Glucose; Dietary Supplement: Sucrose; Dietary Supplement: Maltodextrin; Dietary Supplement: Water
Sponsors: University of Manchester; Cargill
Completed - Condition: Cardiovascular Diseases
Interventions: Biological: Typhoid vaccine; Dietary Supplement: Concentrate beetroot Juice; Dietary Supplement: Concentrate beetroot Juice (Placebo)
Sponsor: Queen Mary University of London
Recruiting - Condition: Contraception
Interventions: Drug: E4/DRSP; Drug: VAL
Sponsors: Estetra; Quotient Sciences
Completed - Conditions: Autoimmune Diseases; Fibrosis
Interventions: Drug: KD025; Drug: [14C]-KD025 solution for infusion, 20 μg/mL; Drug: [14C]-KD025 capsule, 200mg
Sponsors: Kadmon Corporation, LLC; Quotient Sciences
Not yet recruiting - Conditions: Parkinson Disease, PARK8; Parkinson Disease; Idiopathic Parkinson Disease
Intervention:
Sponsors: King's College London; GlaxoSmithKline
Recruiting - Conditions: Allergic Rhinitis; Tachyphylaxis; Rhinitis Medicamentosa
Interventions: Drug: Oxymetazoline 0.05% w/v; Drug: Fluticasone propionate 50 micrograms per actuation; Drug: Prazosin hydrochloride; Drug: Placebo to Prazosin
Sponsor: Brian J Lipworth
Completed - Condition: Major Depressive Disorder
Interventions: Drug: LY2216684; Drug: Placebo; Drug: Lorazepam
Sponsor: Eli Lilly and Company
Completed - Conditions: Cardiovascular Disease; Pulmonary Arterial Hypertension; Heart Failure
Interventions: Drug: BIA 5-1058; Drug: Placebo Oral Tablet; Drug: Moxifloxacin 400 mg
Sponsors: Bial - Portela C S.A.; Covance
Active, not recruiting - Condition: Anemia, Iron-Deficiency
Interventions: Other: Test meal I (given with water); Other: Test meal II (simultaneously with tea); Other: Test meal III (1 hour after test meal); Other: Reference iron dose
Sponsor: University of Chester
Completed - Condition: Hyperlipidemia
Intervention: Drug: [14C-ETC-1002]
Sponsor: Esperion Therapeutics
Completed - Condition: Influenza
Interventions: Biological: CR8020; Biological: Placebo
Sponsors: Crucell Holland BV; Retroscreen Virology Ltd.
Completed - Condition: Filariasis
Intervention: Drug: Emodepside (BAY 44-4400)
Sponsors: Drugs for Neglected Diseases; Bayer; Bill and Melinda Gates Foundation
Completed - Condition: Moderate Pain
Interventions: Drug: 500 mg acetylsalicylic acid (Aspirin, BAYE4465); Drug: 1000 mg acetylsalicylic acid (Aspirin, BAYE4465); Drug: 400 mg ibuprofen(Nurofen); Drug: 400 mg ibuprofen (Dolormin Extra)
Sponsor: Bayer
Completed - Conditions: Parkinson Disease; Parkinsonism
Intervention:
Sponsors: University College, London; European Commission; University of Luxembourg; University of Luebeck; Leiden University Medical Center
Recruiting - Condition: Influenza
Interventions: Drug: CS-8958; Other: Placebo
Sponsors: Biota Scientific Management Pty Ltd; National Institute of Allergy and Infectious Diseases (NIAID)
Completed - Condition: Colitis, Ulcerative
Interventions: Drug: GSK3050002; Drug: Placebo
Sponsors: GlaxoSmithKline; Eisai/Morphotek
Completed - Conditions: Health; Hypertension; Chronic Kidney Disease
Intervention:
Sponsor: University of Edinburgh
Recruiting - Condition: Healthy
Intervention: Device: P200TE
Sponsor: Optos, PLC
Not yet recruiting - Condition: Neisseria Meningitidis Serogroup B
Intervention: Biological: Meningococcal B Vaccine NZ
Sponsor: Public Health England
Completed - Condition: Postpartum Hemorrhage
Interventions: Drug: IH Oxytocin; Drug: IM Oxytocin; Drug: IV Oxytocin; Device: ROTAHALER
Sponsors: GlaxoSmithKline; InVentiv Clinique; Monash University
Terminated - Conditions: Cholestasis; Primary Sclerosing Cholangitis; Primary Biliary Cirrhosis
Interventions: Other: Questionnaire, semen sample, fasting blood sample; Other: Questionnaire; Other: Questionnaire, fasting blood sample
Sponsors: Guy's and St Thomas' NHS Foundation Trust; King's College Hospital NHS Trust
Recruiting - Conditions: Constipation - Functional; Irritable Bowel Syndrome Characterized by Constipation
Interventions: Procedure: MRI Motility; Procedure: High Resolution Manometry; Drug: Bisacodyl; Drug: Hyoscine butylbromide
Sponsors: University of Nottingham; University College, London; Queen Mary University of London
Recruiting - Conditions: Cerebellar Mutism; Posterior Fossa Syndrome
Intervention: Diagnostic Test: Advanced MRI sequences
Sponsor: Great Ormond Street Hospital for Children NHS Foundation Trust
Recruiting - Conditions: Community Acquired Pneumonia; Respiration Failure; Pneumonia
Intervention:
Sponsors: Imperial College London; NIHR HPRU in Respiratory Infections
Completed - Condition: Idiopathic Intracranial Hypertension
Interventions: Procedure: Bariatric surgery; Behavioral: Dietetic intervention
Sponsors: University of Birmingham; National Institute for Health Research, United Kingdom
Active, not recruiting - Condition: Anxiety
Interventions: Other: Cognitive Behavioural Therapy Guided Self Help; Other: Cognitive Analytic Therapy Guided Self Help
Sponsor: University of Sheffield
Recruiting - Condition: Stroke
Intervention:
Sponsor: University Hospitals Coventry and Warwickshire NHS Trust
Recruiting - Conditions: Asthma; COPD; Heart Failure; Community-acquired Pneumonia; Healthy; Breathlessness
Intervention:
Sponsors: University of Leicester; Medical Research Council; Engineering and Physical Sciences Research Council, UK; Loughborough University; University Hospitals, Leicester; Owlstone Ltd; B & S ANALYTIK GmbH; Advion Biosciences Ltd
Recruiting - Condition: Stroke, Acute
Intervention:
Sponsor: Royal Devon and Exeter NHS Foundation Trust
Recruiting - Condition: Osteoarthritis
Intervention:
Sponsor: Cambridge University Hospitals NHS Foundation Trust
Completed - Conditions: Inappropriate Sinus Tachycardia; Pregnancy Related
Interventions: Diagnostic Test: ECG; Diagnostic Test: heart rate monitor; Diagnostic Test: Autonomic Nervous System (ANS) Activity; Diagnostic Test: Haemodynamic variables; Other: Echocardiogram
Sponsor: Cambridge University Hospitals NHS Foundation Trust
Recruiting - Condition: Health Behavior
Interventions: Behavioral: Healthy Parent Carers group programme; Behavioral: Healthy Parent Carers online resources
Sponsors: University of Exeter; University of Oxford
Recruiting - Conditions: Diabetes Mellitus, Type 2; Diabetic Cardiomyopathies
Interventions: Diagnostic Test: Cardiovascular magnetic resonance (CMR) imaging and magnetic resonance spectroscopy; Diagnostic Test: Transthoracic echocardiography; Diagnostic Test: Computed tomography coronary artery calcium scoring; Diagnostic Test: Cardiopulmonary exercise testing
Sponsor: University of Leicester
Recruiting - Condition: Hearing Loss
Intervention: Device: cochlear implants
Sponsor: Manchester University NHS Foundation Trust
Withdrawn - Condition: COPD
Intervention:
Sponsor: North Bristol NHS Trust
Completed - Condition: Cystic Fibrosis
Interventions: Drug: BI 443651; Drug: Placebo
Sponsor: Boehringer Ingelheim
Completed - Condition: Diabetes Mellitus, Type 2
Intervention:
Sponsors: University of Nottingham; University of Adelaide
Recruiting - Condition: Myositis
Intervention: Procedure: Venepuncture
Sponsor: Salford Royal NHS Foundation Trust
Recruiting - Condition: Stroke
Intervention: Behavioral: Reading Training
Sponsor: University College London Hospitals
Active, not recruiting - Condition: Blood Pressure
Interventions: Other: Placebo mouthwash; Other: Chlorhexidine mouthwash
Sponsors: University of Plymouth; University of the West of Scotland
Completed - Condition: Cough
Intervention: Drug: cyclodextrin
Sponsor: Imperial College London
Withdrawn - Condition: Hepatitis B
Interventions: Biological: Hepatitis B; Biological: Tetanus Toxoid
Sponsor: Imperial College London
Completed - Conditions: Insulin Resistance; Age Problems
Interventions: Dietary Supplement: Beta-Hydroxy-Beta-Methylbutyrate; Other: Placebo
Sponsor: University of Nottingham
Completed - Condition: Malaria
Intervention: Biological: ChAd63 ME-TRAP and MVA ME-TRAP vaccination
Sponsor: University of Oxford
Active, not recruiting - Condition: Bipolar Disorder
Interventions: Drug: JNJ-18038683; Drug: Placebo
Sponsor: King's College London
Recruiting - Conditions: Bright Light Treatment; Emotion; Facial Expression Recognition
Interventions: Device: Bright light treatment lamp; Device: Sham negative ion generator
Sponsors: University of Oxford; Medical Research Council; P1vital Products Limited
Completed - Condition: Endometrial Cancer
Intervention: Diagnostic Test: Urinary miRNA
Sponsor: Royal Cornwall Hospitals Trust
Active, not recruiting - Condition: Respiratory Physiology
Intervention: Other: High G acceleration on a long-arm human centrifuge
Sponsors: King's College London; University of Oxford; QinetiQ Ltd; UK Space Agency
Completed - Conditions: Deglutition; Physiology
Intervention: Device: rTMS
Sponsor: University of Manchester
Recruiting - Condition: Autism Spectrum Disorder
Interventions: Drug: Arbaclofen_15; Drug: Arbaclofen_30; Drug: Placebo
Sponsor: King's College London
Recruiting - Condition: Pain
Interventions: Drug: Paracetamol and caffeine; Drug: Paracetamol; Other: Placebo
Sponsor: GlaxoSmithKline
Terminated - Condition: HIV Infection
Interventions: Drug: P2G12 Dose Cohort 1; Drug: P2G12 Dose Cohort 2; Drug: P2G12 Dose Cohort 3
Sponsor: St George's, University of London
Not yet recruiting - Condition: Respiratory Syncytial Virus (RSV) Infection
Interventions: Drug: BTA-C585 oral capsule; Drug: Matching placebo capsules
Sponsor: Biota Pharma Europe Limited
Completed - Condition: Impulsive Behavior
Interventions: Device: Anodal tDCS; Device: Sham tDCS
Sponsors: Najat Khalifa; Medical Research Council; University of Nottingham
Recruiting - Condition: Multiple Sclerosis
Interventions: Drug: XBD173; Drug: Etifoxine
Sponsor: Imperial College London
Recruiting - Conditions: Cerebrovascular Circulation; Affect
Interventions: Other: Tea; Other: Water
Sponsors: Unilever R&D; Liverpool John Moores University
Recruiting - Condition: Acute Lung Injury
Interventions: Drug: Aspirin 75mg; Drug: Lactose powder; Drug: Aspirin 1200mg
Sponsors: Belfast Health and Social Care Trust; The Intensive Care Society United Kingdom; Northern Ireland Clinical Trials Unit; Queen's University, Belfast
Recruiting - Condition: Type 2 Diabetes Mellitus
Intervention: Behavioral: Physical activity
Sponsors: University of Leicester; University Hospitals, Leicester
Recruiting - Condition: Pregnancy Related
Intervention:
Sponsor: University of Nottingham
Completed - Conditions: Study Focus 1:Glycaemic Index; Study Focus 2:Glycaemic Response; Study Focus 3:Insulinemic Response
Intervention: Other: Dietary Intervention
Sponsors: Mondelēz International, Inc.; Reading Scientific Services Ltd.
Withdrawn - Conditions: Cognitive Change; Effects of Ginseng on Cognitive Function
Interventions: Dietary Supplement: Cereboost; Dietary Supplement: Placebo
Sponsors: University of Reading; Naturex
Recruiting - Conditions: Loneliness; Ageing; Physical Activity
Intervention: Behavioral: Group walking and group educational workshops
Sponsor: University of Birmingham
Completed - Conditions: Prebiotics; Anxiety; Humans; Magnetic Resonance Imaging; Decision Making; Emotion; Cortisol
Interventions: Dietary Supplement: Prebiotics; Dietary Supplement: Maltodextrin (placebo)
Sponsors: University of Oxford; National Health and Medical Research Council, Australia; Oxford Health Biomedical Research Centre (OH BRC) support scheme; Wellcome Centre for Integrative Neuroimaging; Monash University
Recruiting - Condition: Amblyopia
Intervention: Diagnostic Test: Visual acuity tests
Sponsor: Anglia Ruskin University
Recruiting - Condition: Obesity
Interventions: Drug: Intranasal Insulin; Drug: Intranasal Placebo
Sponsors: University of Birmingham; Queen Elizabeth Hospital NHS Foundation Trust
Completed - Condition: Drug Intolerance
Interventions: Drug: Atorvastatin; Drug: Placebo
Sponsors: University of Dundee; NHS Tayside
Completed - Conditions: Gut Health; Metabolic Health
Intervention: Dietary Supplement: Soya lecithin
Sponsors: University of Aberdeen; Medical Research Council; University of Liverpool
Recruiting - Condition: Cardiovascular Risk Factor
Interventions: Dietary Supplement: White Bread; Dietary Supplement: Wholegrain bread; Dietary Supplement: Wholegrain Enzyme
Sponsors: University of Reading; Biotechnology and Biological Sciences Research Council
Completed - Condition: RSV Infection
Interventions: Drug: EDP-938 Dose 1; Drug: EDP-938 Dose 2; Drug: Placebo
Sponsors: Enanta Pharmaceuticals; hVIVO Services Limited
Recruiting - Conditions: Oropharyngeal Dysphagia; Stroke
Interventions: Device: Cerebellar TMS; Device: Sham cerebellar TMS
Sponsors: University of Manchester; Medical Research Council; University of Nottingham
Recruiting - Condition: Eustachian Tube Dysfunction
Interventions: Other: Different objective clinical tests of Eustachian tube function; Other: Different patient-completed questionnaires relating to Eustachian tube dysfunction
Sponsor: Cambridge University Hospitals NHS Foundation Trust
Completed - Conditions: Food Preferences; Hunger
Intervention: Behavioral: Food labelling versus no food labelling
Sponsor: St Mary's University College
Recruiting - Condition: RSV Infection
Intervention: Other: Challenge virus RSV-A Memphis 37b
Sponsors: Hvivo; GlaxoSmithKline
Recruiting - Condition: Dentin Sensitivity
Interventions: Device: Stannous fluoride; Other: Sodium monofluorophosphate; Other: Mineral water
Sponsor: GlaxoSmithKline
Completed - Conditions: Postprandial Metabolism; Appetite
Interventions: Other: Carbohydrate rich breakfast; Dietary Supplement: Whey protein enriched breakfast
Sponsor: University of Bath
Recruiting - Condition: Skin Care
Interventions: Other: Test shampoo; Other: Test bath foam; Other: Test head to toe wash
Sponsors: GlaxoSmithKline; TKL Research, Inc.
Completed - Condition: Asthma
Intervention: Procedure: Biofluid sampling
Sponsor: Boehringer Ingelheim
Completed - Conditions: Risk Factor, Cardiovascular; Physical Activity; Pre-diabetes
Intervention: Behavioral: Exercise
Sponsor: Kingston University
Completed - Condition: Immunization; Infection
Intervention: Other: nasal swab
Sponsor: Public Health England
Completed - Conditions: Sarcopenia; Muscle Atrophy
Interventions: Dietary Supplement: Whey Protein; Dietary Supplement: Control; Other: Resistance Exercise
Sponsors: Coventry University; University Hospitals Coventry and Warwickshire NHS Trust
Recruiting - Conditions: Cognitive Function; Mood
Interventions: Dietary Supplement: CP9700; Dietary Supplement: Matched Placebo
Sponsors: University of Reading; Polyphenolics, Inc.
Active, not recruiting - Conditions: Appetitive Behavior; Obesity; Genetic Predisposition to Disease
Intervention: Behavioral: Standardised meal
Sponsors: Loughborough University; Teesside University
Completed - Condition: Glucose Metabolism Disorders
Interventions: Behavioral: Exercise; Behavioral: Breakfast; Behavioral: Maintain habitual habits
Sponsor: University of Bath
Active, not recruiting - Conditions: Dementia; Alzheimer Disease; Mild Cognitive Impairment; Aging; Cognitive Impairment
Intervention: Behavioral: Cognitive Training
Sponsors: University of Leicester; The Dunhill Medical Trust; University Hospitals, Leicester; Leicestershire Partnership Trust; University of Nottingham; Lumosity
Recruiting - Conditions: COPD With Hyperinflation; Diaphragmatic Weakness
Intervention: Diagnostic Test: Upright MRI
Sponsor: University of Nottingham
Recruiting - Condition: Dementia
Interventions: Other: Foods consistent with a MDP; Other: Physical Activity; Other: Control
Sponsor: University of East Anglia
Recruiting - Condition: Acute Lung Injury
Interventions: Drug: Imatinib; Drug: Placebo oral capsule
Sponsors: Exvastat Ltd.; Parexel
Completed - Conditions: Diabetes Mellitus, Type 2; Cardiovascular Diseases; Endothelial Dysfunction; Insulin Resistance; Oxidative Stress
Intervention: Behavioral: Exercise
Sponsors: Loughborough University; University Hospitals, Leicester
Completed - Condition: Tooth Erosion
Interventions: Other: RS01; Other: Water
Sponsors: Unilever R&D; University of Bristol Dental Hospital
Completed - Condition: Newborns
Intervention: Other: Cosmetic Products
Sponsors: Johnson & Johnson Consumer Inc. (J&JCI); University of Sheffield
Active, not recruiting - Conditions: Typhoid Fever; Enteric Fever
Interventions: Biological: Vi-TCV; Biological: Vi-PS Vaccine; Biological: Control (Men ACWY)
Sponsor: University of Oxford
Active, not recruiting - Condition: Cystic Fibrosis
Intervention: Diagnostic Test: MRI scans
Sponsor: Nottingham University Hospitals NHS Trust
Recruiting - Condition: Health Knowledge, Attitudes, Practice
Intervention: Behavioral: Technology-based nutrition education
Sponsors: Kingston University; St George's, University of London; King's College London
Completed - Conditions: Emotional Processing; Mental Exercise
Interventions: Behavioral: Three good things exercise; Behavioral: Placebo exercise
Sponsor: University of Oxford
Completed - Conditions: Diabetes Mellitus, Type 2; Obesity
Intervention: Procedure: Roux-en-Y gastric bypass (RYGB)
Sponsors: Imperial College London; National Institute for Health Research, United Kingdom
Recruiting - Conditions: Haloperidol; Placebo; L-DOPA
Interventions: Drug: Placebo - Cap; Drug: L-dopa; Drug: Haloperidol
Sponsors: King's College London; Medical Research Council
Recruiting - Conditions: Inflammation; Aging
Intervention: Other: Maintaining a normal daily living lifestyle
Sponsor: University of Bath
Active, not recruiting - Conditions: Meningococcal Vaccines; Meningococcal Infections; Neisseria Meningitidis; Factor H-binding Protein, Neisseria Meningitidi
Intervention: Biological: 4CMenB (Bexsero®) - Novartis Vaccines and Diagnostics
Sponsor: University of Oxford
Active, not recruiting - Condition: Atrial Fibrillation
Interventions: Drug: HBI-3000; Other: Placebo
Sponsors: HUYA Bioscience International; Quotient Clinical
Completed - Condition: Erectile Dysfunction
Interventions: Drug: Sublingual sildenafil; Drug: Oral sildenafil
Sponsors: N4 Pharma UK Ltd.; BDD Pharma Ltd
Completed - Conditions: Bulimia Nervosa; Emotions; Emotional Impulsivity
Intervention: Other: No intervention
Sponsors: Bournemouth University; University College, London
Not yet recruiting - Conditions: Muscle Atrophy; Insulin Sensitivity
Interventions: Other: Bed Rest; Other: Reconditioning
Sponsor: University of Nottingham
Active, not recruiting - Condition: Eating Disorders in Adolescence
Intervention: Other: Cognitive Bias Modification
Sponsors: King's College London; South London and Maudsley NHS Foundation Trust; South West London and St George's Mental Health NHS Trust; Ellern Mede Ridgeway
Recruiting - Conditions: Weight; Appetite
Interventions: Other: Active Diet Products; Other: Placebo Diet Products
Sponsors: Professor Jason Halford; University of Copenhagen; University Rovira i Virgili
Completed - Condition: Asthma
Interventions: Biological: Lyophilized mepolizumab; Biological: Liquid mepolizumab; Device: Prefilled autoinjector; Device: Prefilled Safety Syringe
Sponsor: GlaxoSmithKline
Completed - Conditions: Chronic Kidney Disease; Hypertrophy, Left Ventricular; Hypertension
Intervention: Procedure: Nephrectomy
Sponsor: University Hospital Birmingham NHS Foundation Trust
Recruiting - Condition: Gastrointestinal Symptoms
Interventions: Other: Whole apples; Other: Apple puree; Other: Apple Juice
Sponsors: University of Nottingham; King's College London
Completed - Condition: Cardiovascular Diseases
Intervention:
Sponsors: NHS Greater Glasgow and Clyde; University of Glasgow
Recruiting - Condition: Acute Coronary Syndrome
Interventions: Drug: Aspirin; Drug: Ticagrelor
Sponsor: Sheffield Teaching Hospitals NHS Foundation Trust
Not yet recruiting - Condition: Meningitis
Intervention: Biological: 4CMenB
Sponsors: University of Oxford; Public Health England; Imperial College London; Novartis Vaccines; European Commission
Completed - Condition: Pre-Diabetes
Intervention: Behavioral: Consultation
Sponsors: Aberystwyth University; Hywel Dda Health Board
Active, not recruiting - Condition: Muscle Disuse Atrophy
Interventions: Dietary Supplement: Leucine; Dietary Supplement: Placebo
Sponsor: University of Birmingham
Active, not recruiting - Condition: Retina; Change
Intervention:
Sponsor: University of Oxford
Completed - Condition: Nutrition and Energy Balance
Intervention: Other: Diet
Sponsor: University of Bath
Completed - Condition: Type2 Diabetes
Intervention: Dietary Supplement: Orange juice
Sponsors: University Hospitals Coventry and Warwickshire NHS Trust; University of Warwick
Recruiting - Conditions: Huntington's Disease; Tourette Syndrome
Intervention: Other: Transcranial direct current stimulation
Sponsors: Birmingham and Solihull Mental Health NHS Foundation Trust; University of Birmingham
Active, not recruiting - Condition: Dementia Alzheimers
Intervention: Other: Standard Diet
Sponsors: University of Aberdeen; NHS Grampian; Tenovus Scotland
Recruiting - Conditions: Exercise Training; Biomarkers
Intervention: Biological: Cardiometabolic biomarkers
Sponsors: University of Hertfordshire; Medichecks; Watford FC Community Sports and Education Trust
Enrolling by invitation - Conditions: Lipid Metabolism; Substrate Metabolism; Exercise
Intervention: Behavioral: Study Protocol
Sponsor: University of Bath
Recruiting - Condition: Body Composition, Beneficial
Intervention:
Sponsor: University of Reading
Recruiting - Condition: COPD
Intervention: Other: capacity of primary phagocytes
Sponsor: Sheffield Teaching Hospitals NHS Foundation Trust
Completed - Condition: Alpha-1 Antitrypsin Deficiency
Interventions: Drug: ARC-AAT Injection; Other: Placebo; Drug: Diphenhydramine
Sponsor: Arrowhead Pharmaceuticals
Terminated - Condition: Adenocarcinoma
Intervention: Procedure: Imaging
Sponsor: Institute of Cancer Research, United Kingdom
Recruiting - Conditions: Congestive Heart Failure; Heart Failure
Intervention:
Sponsor: University of Dundee
Completed - Condition: Meningitis, Meningococcal
Intervention: Biological: Neisseria lactamica
Sponsors: University Hospital Southampton NHS Foundation Trust; University of Southampton
Recruiting - Condition: Tolerance
Interventions: Drug: Metformin; Drug: Omeprazole; Drug: Placebo
Sponsors: NHS Tayside; University of Dundee
Completed - Conditions: Myeloma; Monoclonal Gammopathy of Undetermined Significance (MGUS); Smouldering Myeloma
Interventions: Other: Diffusion Weighted Magnetic Resonance Imaging (DWMRI); Other: DXA scan; Other: Bloods and urine
Sponsors: Oxford University Hospitals NHS Trust; Amgen
Recruiting - Conditions: Concussion, Brain; Motor Vehicle Accident
Interventions: Diagnostic Test: Clinical assessment (SCAT5); Diagnostic Test: ImPACT; Behavioral: CANTAB; Diagnostic Test: I-PAS; Biological: Saliva sample; Other: fMRI
Sponsors: University of Cambridge; Global Institute for Motorsport Safety (GIMSS); Neuro Kinetics Incorporated; Cambridge University Hospitals NHS (National Health Service) Foundation Trust; Federation Internacionale de l'Automobile
Recruiting - Condition: Childhood Obesity
Interventions: Behavioral: Optimisation + HENRY; Behavioral: HENRY as standard
Sponsor: University of Leeds
Completed - Condition: Cystic Fibrosis
Intervention: Other: None. Not applicable
Sponsor: Queen Mary University of London
Recruiting - Conditions: Cardiovascular Disease; Diabetes; Bone Disease
Interventions: Dietary Supplement: Vitamin D3; Other: Placebo
Sponsor: University of Chester
Completed - Condition: Patellar Dislocation
Interventions: Other: Gait analysis; Other: Electromyography; Procedure: Intra-operative tracking and pressure measurements
Sponsors: St George's, University of London; Imperial College London
Recruiting - Condition: Chronic Obstructive Pulmonary Disease
Interventions: Drug: d-cycloserine; Drug: placebo
Sponsors: University of Oxford; National Health Service, United Kingdom
Recruiting - Conditions: Frailty; Sarcopenia; Aging
Interventions: Behavioral: Consultation; Behavioral: Online Support; Behavioral: Empowered
Sponsors: Aberystwyth University; EIT Health
Active, not recruiting - Condition: Cirrhosis of the Liver
Interventions: Biological: Faecal microbiota transplantation; Biological: Placebo
Sponsors: King's College London; King's College Hospital NHS Trust
Recruiting - Conditions: AMD; Diabetic Retinopathy; Retinal Degeneration; Retinal Dystrophies
Intervention: Device: Combined Coaxial Optical Coherence Tomography
Sponsor: Moorfields Eye Hospital NHS Foundation Trust
Recruiting - Conditions: Contraception; Menopause
Intervention: Drug: Estetrol
Sponsors: Estetra; Quotient Clinical
Completed - Conditions: Physical Activity; Health Behavior
Intervention: Behavioral: HealthyKidz physical activity programme
Sponsor: Queen's University, Belfast
Completed - Condition: Cerebral Blood Flow and Neonates During Acute Respiratory Failure
Intervention: Other: TCD
Sponsors: Liverpool John Moores University; Alder Hey Children's NHS Foundation Trust
Recruiting - Conditions: Blood Biomarkers; Vasodilation; Blood Clotting; Lung Function; Healthy Volunteers
Interventions: Other: diesel exhaust particulate; Other: carbon nanoparticles; Other: small graphene oxide; Other: ultrasmall graphene oxide; Other: filtered air
Sponsors: University of Edinburgh; NHS Lothian
Recruiting - Conditions: Kidney Failure, Chronic; Renal Insufficiency, Chronic
Intervention: Drug: LY2409021
Sponsor: Eli Lilly and Company
Completed - Conditions: Primary Open Angle Glaucoma; Normal Tension Glaucoma; Ocular Hypertension
Intervention:
Sponsor: University of Plymouth
Completed - Conditions: Diabetes Mellitus; Healthy Volunteers
Interventions: Device: Frazier 3 Verio; Device: Frazier 3 UltraPlus
Sponsors: LifeScan; Institute for Diabetes-Technology GmbH
Completed - Conditions: Pollution; Exposure; Health Behavior
Intervention: Behavioral: Alternative health advice
Sponsors: King's College London; National Institute for Health Research, United Kingdom; Public Health England
Completed - Conditions: Obesity; Smoking Cessation; Alcoholism
Interventions: Drug: Exenatide; Biological: Desacyl ghrelin; Biological: Saline
Sponsor: Imperial College London
Recruiting - Condition: Tuberculosis
Interventions: Biological: Aerosol inhaled MVA85A; Biological: Intramuscular MVA85A; Biological: Intramuscular Saline placebo; Biological: Aerosol inhaled Saline placebo
Sponsors: University of Oxford; University of Birmingham
Terminated - Condition: Cystic Fibrosis
Interventions: Drug: Placebo; Drug: QBW251
Sponsor: Novartis Pharmaceuticals
Terminated - Condition: Autism Spectrum Disorder
Intervention: Device: Transcranial direct current stimulation (tDCS)
Sponsors: NHS Greater Glasgow and Clyde; University of Glasgow
Completed - Conditions: Neisseria Meningitidis; Haemophilus Influenzae Type b
Interventions: Biological: GSK2197870A; Biological: Prevenar™; Biological: Menitorix™; Biological: Pediacel™; Biological: Menjugate™
Sponsor: GlaxoSmithKline
Completed - Condition: Breast Milk Collection
Intervention: Other: Laboratory analysis
Sponsor: Bournemouth University
Completed - Conditions: Healthy Volunteer - Complete; Cystic Fibrosis
Interventions: Drug: PTI-808; Drug: Placebo; Drug: PTI-428; Drug: PTI-801
Sponsor: Proteostasis Therapeutics, Inc.
Recruiting - Conditions: Type 2 Diabetes; Chronic Disease; Obesity
Intervention: Behavioral: Interactive Lifestyle programme workshop
Sponsors: University Hospitals, Leicester; University of Leicester; Associacao Protectora dos Diabeticos de Portugal; The Algarve Regional Health Administration; University of Leipzig; Technische Universität Dresden; Alexander Technological Educational Institute, Thessaloniki, Greece; Diabetes Centre of Paediatrics P&A; Primary Care Centre Egia, San Sebastian, Spain; Basque Government Department of Public Health; Health Department of the Alto/Bajo Deba
Completed - Conditions: Cystic Fibrosis; Primary Ciliary Dyskinesia; Bronchiectasis; Asthma; Bronchitis; Sleep Disorder
Intervention: Device: Multiple breath washout testing
Sponsor: Imperial College London
Recruiting - Condition: Myeloma
Intervention: Other: Machine Learning (ML)
Sponsors: Royal Marsden NHS Foundation Trust; Institute of Cancer Research, United Kingdom; Imperial College London
Recruiting - Condition: Renal Disease
Interventions: Other: 3 Tesla multiparametric MR; Other: renal histopathology scoring; Biological: Blood and urine sampling; Biological: Iohexol clearance test
Sponsor: University of Nottingham
Recruiting - Conditions: Sarcopenia; Muscular Atrophy
Interventions: Dietary Supplement: Protein Supplementation; Other: Aerobic Exercise; Other: Resistance Exercise
Sponsor: Liverpool Hope University
Recruiting - Condition: Obesity in Pregnancy
Intervention: Behavioral: Foodwise in Pregnancy
Sponsors: Cwm Taf University Health Board (NHS); Burdett Trust for Nursing; Public Health Wales NHS Trust; Swansea University; Cardiff Metropolitan University; Cardiff University
Active, not recruiting - Conditions: Safety; Immunogenicity
Interventions: Biological: ChAdOx185A; Biological: MVA85A; Biological: BCG
Sponsors: University of Oxford; MRC/UVRI and LSHTM Uganda Research Unit
Not yet recruiting - Condition: Urticaria
Interventions: Drug: GSK2646264 0.5% topical cream; Drug: GSK2646264 1% topical cream; Drug: Placebo
Sponsor: GlaxoSmithKline
Completed - Condition: Cough
Interventions: Drug: BAY1902607; Drug: Matching placebo; Drug: Midazolam
Sponsor: Bayer
Recruiting - Condition: Cough
Interventions: Drug: BAY1817080; Drug: Matching Placebo
Sponsor: Bayer
Active, not recruiting - Condition: Preeclampsia
Intervention: Device: TheraSorb sFlt-1 adsorber
Sponsors: Miltenyi Biotec GmbH; Cromsource
Recruiting - Condition: Healthy
Interventions: Biological: MVA-BN-Filo; Biological: Ad26.ZEBOV; Biological: Placebo
Sponsor: Janssen Vaccines & Prevention B.V.
Completed - Conditions: Asthma; Heart Failure; Pneumonia; Motor Neuron Disease; Vocal Cord Dysfunction; Breathlessness
Intervention:
Sponsors: Cambridge Respiratory Innovations Limited; Innovate UK
Completed - Condition: Healthy Volunteers
Interventions: Biological: TDV; Biological: Placebo; Biological: HAV Vaccine
Sponsor: Takeda
Active, not recruiting - Conditions: Liver Diseases; Primary Biliary Cirrhosis; Non-Alcoholic Fatty Liver Disease; Non-Alcoholic Steatohepatitis; Cirrhosis; Hemochromatosis; Viral Hepatitis; Autoimmune Hepatitis; Primary Sclerosing Cholangitis
Intervention: Device: LiverMultiScan
Sponsor: Perspectum Diagnostics Ltd
Active, not recruiting - Conditions: Heart Failure; Pulmonary Hypertension; Myocardial Infarction; Coronary Artery Disease
Intervention: Other: intravenous fluid challenge
Sponsor: Sheffield Teaching Hospitals NHS Foundation Trust
Suspended - Conditions: Mesothelioma; Lung Neoplasms; Surgery; Cystic Fibrosis; Pectus Carinatum; Pectus Excavatum; Empyema, Pleural; Pulmonary Disease, Chronic Obstructive
Intervention: Other: Chest wall motion analysis
Sponsors: Heart of England NHS Trust; University of Birmingham; University of Warwick
Completed - Condition: Pulmonary Disease, Chronic Obstructive
Intervention: Procedure: sputum, blood, condensate
Sponsor: Imperial College London
Completed - Conditions: Ulcerative Colitis; Crohn's Disease
Interventions: Drug: Placebo; Drug: UTTR1147A
Sponsor: Genentech, Inc.
Recruiting - Condition: Chronic Hepatitis B
Interventions: Drug: ABI-H2158; Drug: Placebo for ABI-H2158
Sponsor: Assembly Biosciences
Recruiting - Condition: Respiratory Syncytial Virus Infections
Interventions: Drug: MEDI8897; Drug: Placebo
Sponsor: MedImmune LLC
Completed - Conditions: Hemophilia A; Hemophilia B
Interventions: Drug: ALN-AT3SC; Drug: Sterile Normal Saline (0.9% NaCl)
Sponsor: Alnylam Pharmaceuticals
Completed - Condition: Bipolar Depression
Intervention: Other: Behavioural Activation (BA)
Sponsors: University of Exeter; Devon Partnership NHS Trust
Recruiting - Condition: Hepatitis B, Chronic
Interventions: Other: Placebo; Drug: RO7020531
Sponsor: Hoffmann-La Roche
Recruiting - Conditions: Congenital Bleeding Disorder; Haemophilia A; Haemophilia B; Healthy
Interventions: Drug: NNC 0172-0000-2021; Drug: placebo
Sponsor: Novo Nordisk A/S
Completed - Condition: Heart Failure
Interventions: Drug: Placebo; Drug: BMS-986224
Sponsor: Bristol-Myers Squibb
Active, not recruiting - Condition: Cystic Fibrosis
Interventions: Drug: VX-121; Drug: TEZ/IVA; Drug: IVA; Drug: Matched Placebo
Sponsor: Vertex Pharmaceuticals Incorporated
Active, not recruiting - Conditions: Diabetes; Heart Diseases; Diet Habit; Diet Modification; Microbial Colonization; Healthy; Obesity; Metabolism
Intervention: Other: Dietary intervention
Sponsors: Guy's and St Thomas' NHS Foundation Trust; King's College London; Massachusetts General Hospital
Recruiting - Condition: Diabetes
Interventions: Drug: Moxifloxacin; Other: hyper-glycaemic clamp
Sponsor: Richmond Pharmacology Limited
Recruiting - Condition: Non-Alcoholic Fatty Liver Disease
Interventions: Dietary Supplement: Synbiotic; Dietary Supplement: Maltodextrin
Sponsors: University Hospital Southampton NHS Foundation Trust; National Institute for Health Research, United Kingdom
Recruiting - Condition: Cervical Spine
Intervention: Device: spinal collar
Sponsors: Imperial College Healthcare NHS Trust; The Wellington Hospital, London; Imperial College London
Recruiting - Conditions: Mood; Cognitive Change
Intervention: Biological: Salt with / without water
Sponsor: Swansea University
Recruiting - Condition: Diet Modification
Interventions: Dietary Supplement: Phytin, rice extract; Other: MCC, placebo
Sponsors: Quadram Institute Bioscience; Norfolk and Norwich University Hospitals NHS Foundation Trust
Not yet recruiting - Conditions: Alopecia Areata; Social Anxiety
Intervention: Behavioral: Mindfulness Based Cognitive Therapy
Sponsors: University of Sheffield; Alopecia UK
Recruiting - Conditions: Lamin A/C Gene Mutation; Dilated Cardiomyopathy, Familial
Intervention:
Sponsors: University College, London; NIHR Rare Diseases Translational Research Collaboration; Barts Cardiovascular registry
Not yet recruiting - Condition: Effect of Training
Intervention: Behavioral: ACTr (Acceptance and Commitment Training)
Sponsors: Bournemouth University; Royal Bournemouth and Christchurch Hospitals NHS Foundation Trust
Recruiting - Condition: Muscle Damage
Interventions: Device: Compression garments; Other: Sham recovery drink
Sponsors: St Mary's University College; Modern Pentathlon GB
Recruiting - Condition: Sedentary Lifestyle
Intervention: Behavioral: Breaking up sitting
Sponsor: University of Bedfordshire
Active, not recruiting - Condition: Overweight
Interventions: Behavioral: Single self-incentivising implementation intention; Behavioral: Multiple self-incentivising implementation intentions; Behavioral: Self-generated self-incentivising implementation intentions
Sponsor: University of Manchester
Completed - Conditions: Cholestasis of Pregnancy; Intrahepatic Cholestasis of Pregnancy; Obstetric Cholestasis
Intervention: Device: Monica AN24
Sponsors: Guy's and St Thomas' NHS Foundation Trust; King's College London
Recruiting - Condition: Laparoscopic Training
Interventions: Device: Computerized Laparoscopic Trainer; Device: Box trainer with eye patch
Sponsor: University of Nottingham
Completed - Condition: Myopia
Interventions: Device: First pair Senofilcon A contact lens; Device: Second pair Senofilcon A contact lens; Device: Third pair Senofilcon A contact lens
Sponsors: Graeme Young; Visioncare Research Ltd.
Completed - Conditions: Insulin Resistance; Type2 Diabetes Mellitus; Non-Alcoholic Fatty Liver Disease; Obesity
Intervention: Dietary Supplement: High-fat diet
Sponsors: Loughborough University; Nottingham Trent University; Nottingham University Hospitals NHS Trust
Completed - Conditions: Congenital Bleeding Disorder; Haemophilia A; Healthy
Intervention: Drug: NNC172-2021
Sponsor: Novo Nordisk A/S
Terminated - Conditions: Interstitial Lung Disease; Idiopathic Pulmonary Fibrosis; Connective Tissue Related ILD; Chronic Hypersensitivity Pneumonitis; Fibrotic Lung Disease
Interventions: Behavioral: Focus groups; Behavioral: Semi-structured interviews
Sponsors: Kingston University; St. George's Hospital, London; University College London Hospitals
Recruiting - Conditions: Crossing Infections; Drug Resistance, Microbial
Intervention: Other: Exposure
Sponsors: Glasgow Caledonian University; University of Strathclyde; Nick Graves Independent Consultant; NHS Lothian; NHS Lanarkshire
Recruiting - Conditions: Childbirth Problems; Labor Complication
Interventions: Device: Cook cervical balloon; Drug: Prostin E2 Vaginal Suppository
Sponsors: St George's, University of London; City, University of London
Active, not recruiting - Condition: Ebola Virus Disease
Intervention: Biological: Previously exposed to Ebola vaccine
Sponsors: University of Oxford; University of Glasgow
Enrolling by invitation - Condition: Visual Acuity
Interventions: Device: Test 8.5BC; Device: Test 9.0BC; Device: Control 8.5BC; Device: Control 9.0BC
Sponsor: Johnson & Johnson Vision Care, Inc.
Completed - Condition: Psychological Stress
Intervention: Behavioral: The self-help book: Williams, M. & Penman, D. (2011). Mindfulness: A practical guide to finding peace in a frantic world. London: Piatkus.
Sponsors: Canterbury Christ Church University; Sussex Partnership NHS Foundation Trust; University of Sussex
Completed - Conditions: Breast Feeding; Body Temperature Changes
Intervention: Device: skin-to-skin facilitating garment
Sponsor: Birmingham City University
Recruiting - Conditions: Vaccination; Immunization
Interventions: Biological: Synflorix; Biological: Prevenar13
Sponsors: Public Health England; Imperial College London; Institute of Child Health
Withdrawn - Condition: Neuroblastoma
Interventions: Drug: Nivolumab; Drug: Ch14.18/CHO
Sponsors: University Hospital Southampton NHS Foundation Trust; University College London Hospitals NHS Foundation Trust; University of Wisconsin, Madison; University Hospital Greifswald; Solving Kids' Cancer US/EU; Joining Against Cancer in Kids; The Band of Parents
Recruiting - Condition: Meningococcal Disease
Intervention: Other: venepuncture only
Sponsor: Public Health England
Completed - Condition: Human Papillomavirus Virus
Intervention: Other: venepuncture
Sponsor: Public Health England
Completed - Condition: Dentin Sensitivity
Intervention: Drug: stannous fluoride
Sponsor: GlaxoSmithKline
Completed - Conditions: Hyperopia; Amblyopia; Anisohyperopia
Interventions: Device: Multifocal contact lenses; Device: Single vision contact lenses
Sponsors: Aston University; College of Optometrists
Recruiting - Condition: Infections, Papillomavirus
Interventions: Biological: Cervarix; Biological: Placebo control
Sponsor: GlaxoSmithKline
Completed - Condition: Lower Limb Amputation
Intervention: Other: Home-based Games Console Balance Training
Sponsors: Nottingham Trent University; Nottingham University Hospitals NHS Trust; University of Hull; Bournemouth University; Jonkoping University
Terminated - Conditions: Pertussis; Meningitis; Preventive Immunization; Meningitis; Immunization
Interventions: Biological: Meningococcal vaccine; Drug: Pertussis containing vaccine
Sponsor: Public Health England
Completed - Condition: Nasal Carriage of Pneumococci
Intervention: Other: nasopharyngeal swab
Sponsor: Public Health England
Completed - Condition: Diabetes Mellitus
Intervention: Other: Glucose-Potentiated Arginine-Induced Insulin Secretion
Sponsors: Royal Devon and Exeter NHS Foundation Trust; University of Exeter; University of Oxford; Oxford University Hospitals NHS Trust
Recruiting - Conditions: ICP; GDM
Intervention:
Sponsor: Imperial College London
Recruiting - Condition: Arthritis
Interventions: Other: Prospective - Factors affecting sexual function pre-THR; Other: Retrospective- Factors affecting sexual function post-THR
Sponsor: University Hospital Southampton NHS Foundation Trust
Withdrawn - Conditions: Type 2 Diabetes; Ageing
Interventions: Dietary Supplement: Beetroot juice; Dietary Supplement: Placebo
Sponsors: University of Exeter; Royal Devon and Exeter NHS Foundation Trust
Completed - Conditions: Alzheimer's Disease; Plaque, Amyloid
Intervention:
Sponsor: Janssen Research & Development, LLC
Active, not recruiting - Condition: Vasculitis
Interventions: Drug: BQ123; Drug: BQ123/788; Drug: Placebo
Sponsors: University of Edinburgh; British Heart Foundation
Recruiting - Condition: Primary Hyperoxaluria Type 1 (PH1)
Interventions: Drug: Lumasiran; Drug: Sterile Normal Saline (0.9% NaCl)
Sponsor: Alnylam Pharmaceuticals
Completed - Condition: Retinitis Pigmentosa
Intervention: Device: Transcorneal electrical stimulation
Sponsors: University of Oxford; Oxford University Hospitals NHS Trust; Moorfields Eye Hospital NHS Foundation Trust
Completed - Conditions: Intrahepatic Cholestasis of Pregnancy; Gestational Diabetes Mellitus
Intervention:
Sponsor: Imperial College London
Recruiting - Condition: Pregnancy
Intervention:
Sponsor: SPD Development Company Limited
Completed - Conditions: Stress Fracture; Injury
Interventions: Dietary Supplement: Supplementation Vitamin D3; Dietary Supplement: Placebo
Sponsors: University of Surrey; Institute of Naval Medicine; CTRM Lympstone; Navy Command Headquarters
Recruiting - Conditions: Attitude; Risk-Taking
Intervention: Other: Attitudinal measures
Sponsor: University of Birmingham
Recruiting - Condition: Pain
Intervention: Other: Live Music
Sponsor: Alder Hey Children's NHS Foundation Trust
Recruiting - Condition: Metabolic Syndrome
Interventions: Dietary Supplement: Ready-made pancakes enriched with docosahexaenoic acid (DHA); Dietary Supplement: Ready-made pancakes enriched with beta-glucan (BG); Dietary Supplement: Ready-made pancakes enriched with anthocyanins (AC); Dietary Supplement: Ready-made pancakes enriched with docosahexaenoic acid and beta-glucan (DHA+BG); Dietary Supplement: Ready-made pancakes enriched with docosahexaenoic acid and anthocyanins (DHA+AC)
Sponsors: University of Leeds; The Leeds Teaching Hospitals NHS Trust; AdWare Research Ltd.; University of Bologna; European Union
Completed - Conditions: Vaccination; Infection
Interventions: Other: Standardised Digital Intervention; Other: Individualised Digital Intervention
Sponsors: University of Nottingham; Public Health England
Not yet recruiting - Condition: Chronic Pain
Intervention: Device: Transcranial direct current stimulation
Sponsor: University of Oxford
Recruiting - Conditions: Diabetes Mellitus, Type 2; Cardiovascular Diseases; Endothelial Dysfunction; Insulin Resistance; Oxidative Stress
Intervention: Behavioral: Exercise
Sponsors: Loughborough University; University Hospitals, Leicester
Recruiting - Conditions: Breast Pain; Mastalgia
Interventions: Behavioral: Breast Pain video; Behavioral: Semi-structure interviews
Sponsor: Royal Marsden NHS Foundation Trust
Not yet recruiting - Conditions: Shock; Sepsis; Surgery
Intervention: Device: WellBeing catheter
Sponsors: University College London Hospitals; Wellcome Trust; Department of Health, United Kingdom
Recruiting - Conditions: Cancer; Lung Cancer
Intervention: Radiation: Low Dose CT scan
Sponsors: University College, London; GRAIL, Inc.; University College London Hospitals
Enrolling by invitation - Condition: Familial Hypercholesterolemia
Intervention: Other: FAMCAT
Sponsors: University of Nottingham; Newcastle University; University College, London; University of Manchester
Enrolling by invitation - Condition: Pilonidal Sinus
Interventions: Procedure: EPSiT; Procedure: Excision
Sponsor: St Helens & Knowsley Teaching Hospitals NHS Trust
Completed - Condition: Physical Activity
Intervention: Other: Diet
Sponsor: University of Bath
Recruiting - Condition: Parent-Child Relations
Intervention: Behavioral: The Open Door Approach to Parenting Teenagers (APT)
Sponsor: Open Door Young People's Service
Recruiting - Condition: Obstetric Anal Sphincter Injury
Intervention: Diagnostic Test: three dimensional Transperineal Ultrasound Scan
Sponsor: Lewisham and Greenwich NHS Trust
Recruiting - Conditions: Arrhythmia; Sudden Cardiac Death; Cardiomyopathy, Dilated; Obesity; Inflammation
Intervention: Other: Electrocardiographic imaging
Sponsors: Imperial College London; University College, London
Not yet recruiting - Conditions: Pregnancy Related; Immunization; Infection; Pertussis
Intervention: Biological: Pertussis containing vaccine
Sponsors: St George's, University of London; Thrasher Research Fund; Department of Health, United Kingdom
Not yet recruiting - Conditions: Circadian Rhythms; Feeding Patterns
Interventions: Other: Constant; Other: Bolus
Sponsors: University of Bath; Nestlé
Recruiting - Condition: Exercise
Interventions: Other: Glucose alone; Other: Galactose alone; Other: Glucose and galactose
Sponsors: University of Birmingham; Dairy Management Inc.
Not yet recruiting - Condition: Aging
Intervention: Other: Anticipatory Care Plan group
Sponsors: Queen's University, Belfast; Royal College of Surgeons, Ireland; National University of Ireland, Galway, Ireland
Recruiting - Condition: Aphakia
Intervention: Device: Softec HP1 Intraocular Lens
Sponsor: Lenstec Incorporated
Not yet recruiting - Conditions: Cardiovascular Risk Factor; Cardiovascular Diseases; Diabetes; Physical Activity; Sedentary Lifestyle
Interventions: Other: Breaking up sitting with walking breaks; Other: Prolonged sitting
Sponsor: University of Bedfordshire
Recruiting - Conditions: Dietary Modification; Dietary Habits
Interventions: Behavioral: Non-personalised diet advice (control); Behavioral: Personalised diet advice (intervention)
Sponsor: University of Reading
Not yet recruiting - Condition: Very Premature Baby
Interventions: Behavioral: ACT; Behavioral: Control
Sponsors: Queen's University, Belfast; Public Health Agency, Health and Social Care Research and Development; TinyLife
Recruiting - Condition: Arthroplasty, Replacement, Knee
Interventions: Procedure: Revision TKR surgery; Other: No intervention.
Sponsors: University of Bath; North Bristol NHS Trust
Not yet recruiting - Condition: Impression Cytology
Intervention:
Sponsor: Johnson & Johnson Vision Care, Inc.
Recruiting - Condition: Salmonella Typhi Infection
Intervention: Biological: Salmonella Typhi challenge
Sponsor: University of Oxford
Not yet recruiting - Conditions: Complex Regional Pain Syndromes; Fibromyalgia; Stroke; Traumatic Brain Injury; Osteoarthritis; Back Pain; Sciatica
Intervention: Device: Virtual Environment Biofeedback
Sponsor: Cambridge University Hospitals NHS Foundation Trust
Enrolling by invitation - Conditions: Stroke; Silent Cerebral Infarction; Neurocognitive Dysfunction; Vascular Brain Injury
Interventions: Other: CO2 flushing; Other: Saline flushing
Sponsors: Imperial College London; Imperial College Healthcare NHS Trust; Guy's and St Thomas' NHS Foundation Trust; St George's University Hospitals NHS Foundation Trust; Cambridge University Hospitals NHS Foundation Trust
Not yet recruiting - Conditions: Overweight; Obesity; Infertility, Female
Interventions: Drug: Saxenda; Other: Lifestyle modification; Diagnostic Test: Metabolomics; Diagnostic Test: miRNA
Sponsors: University Hospitals Coventry and Warwickshire NHS Trust; Kingston University; University of Warwick; University of Birmingham
Recruiting - Condition: Old Age; Debility
Intervention: Other: Infra red thermal imaging
Sponsors: Sheffield Teaching Hospitals NHS Foundation Trust; Sheffield Hallam University
Completed - Condition: Hearing Loss
Intervention:
Sponsors: Emily Woodhouse; University of East Anglia; GN Otometrics
Completed - Condition: Diabetes Mellitus
Intervention: Device: FreeStyle Libre Pro
Sponsor: The Leeds Teaching Hospitals NHS Trust
Recruiting - Condition: Visual Acuity
Interventions: Device: AquaComfort Plus; Device: Acuvue Oasys 1-Day
Sponsor: Johnson & Johnson Vision Care, Inc.
Recruiting - Condition: Salt Intake
Intervention:
Sponsor: St Mary's University College
Not yet recruiting - Condition: Critical Illness
Intervention: Other: Mobilization
Sponsor: Imperial College London
Recruiting - CMO Letter to Reduce Unnecessary Antibiotic Prescribing and Broad Spectrum Prescribing Winter 2018-9Condition: Prescribing, Off-Label
Interventions: Behavioral: new social norm feedback letter with bar chart; Behavioral: standard social norm feedback letter
Sponsor: Public Health England
Recruiting - Conditions: Screening; Aortic Aneurysm and Dissection; Genetic Disease
Interventions: Genetic: WES; Diagnostic Test: MRI; Diagnostic Test: TTE; Other: Questionnaire
Sponsor: University of Leicester
Recruiting - Condition: Infertility, Subfertility
Interventions: Diagnostic Test: Endometrial Pattern on Ultrasound at ET; Diagnostic Test: Endometrial Pattern on Ultrasound at HCG; Diagnostic Test: Endometrial Pattern on Ultrasound at TVOR; Diagnostic Test: Endometrial Pattern on Ultrasound at co-ordination scan; Diagnostic Test: Endometrial thickness at HCG; Diagnostic Test: Endometrial thickness at TVOR; Diagnostic Test: Endometrial thickness at ET; Diagnostic Test: Endometrial thickness at coordination scan; Diagnostic Test: Endometrial volume at HCG; Diagnostic Test: Endometrial volume at TVOR; Diagnostic Test: Endometrial volume at ET; Diagnostic Test: Endometrial volume at coordination scan; Diagnostic Test: Blood test for progesterone at HCG; Diagnostic Test: Blood test for progesterone at TVOR; Diagnostic Test: Blood test for progesterone at ET; Diagnostic Test: Blood test for progesterone at coordination scan; Diagnostic Test: Change in endometrial pattern between TVOR and ET; Diagnostic Test: Blood test for estradiol at HCG; Diagnostic Test: Blood test for estradiol at TVOR; Diagnostic Test: Blood test for estradiol at ET; Diagnostic Test: Blood test for estradiol at coordination scan; Diagnostic Test: Endometrial blood flow (doppler) at HCG; Diagnostic Test: Endometrial blood flow (doppler) at TVOR; Diagnostic Test: Endometrial blood flow (doppler) at ET; Diagnostic Test: Endometrial blood flow (doppler) at coordination scan; Diagnostic Test: Contractility at embryo transfer on a subgroup of participants; Diagnostic Test: Change in endometrial pattern between coordination scan and ET; Diagnostic Test: Change in endometrial pattern between HCG and ET
Sponsor: University of Nottingham
Recruiting - Conditions: Positive Communication (Primary); Negative Communication; Control Condition
Intervention: Behavioral: communication type
Sponsor: Swansea University
Completed - Conditions: Mental Health Wellness 1; Anxiety; Self Esteem
Intervention: Behavioral: Self-affirmation
Sponsor: University of Manchester
Completed - Condition: Hearing Loss, Cochlear
Intervention: Procedure: Electrocochleography
Sponsor: Guy's and St Thomas' NHS Foundation Trust
Recruiting - Condition: Modulation of Cognitive Flexibility by Transcranial Direct Current Stimulation, Tyrosine Administration and Polymorphisms in the COMT Gene
Intervention: Combination Product: tdcs (sham/anodal) + drug (placebo/tyrosine)
Sponsor: Sheffield Hallam University
Recruiting - Condition: Cannabis Use
Intervention: Behavioral: Volitional help sheet
Sponsor: University of Manchester
Recruiting - Condition: Dental Trauma
Intervention: Other: Root canal treatment.
Sponsors: University of Edinburgh; NHS Lothian
Recruiting - Condition: Corneal Astigmatism
Interventions: Procedure: Trans-epithelial PTK; Device: EpiMaster Application Software
Sponsors: London Vision Clinic; Carl Zeiss Meditec AG; Optana GmbH
Not yet recruiting - Conditions: Inflammatory Bowel Diseases; Ulcerative Colitis; Crohn Disease
Intervention: Other: No intervention
Sponsors: Momentum Data; Pfizer; University of Surrey
Active, not recruiting - Conditions: Venous Thromboses; Venous Thromboembolism; Deep Vein Thrombosis; Pulmonary Embolism; Rheumatoid Arthritis; Inflammatory Bowel Diseases; Ulcerative Colitis; Crohn Disease; Psoriatic Arthritis
Intervention: Other: No intervention
Sponsors: Momentum Data; Pfizer; University of Surrey
Active, not recruiting - Conditions: Gamma-Aminobutyric Acid; Anxiety; Glutamate; Emotion Regulation Abilities
Interventions: Dietary Supplement: Galacto-oligosaccharides; Dietary Supplement: Maltodextrin
Sponsors: University of Surrey; FrieslandCampina
Recruiting - Conditions: Anemia; Iron Deficiency Anemia
Intervention: Device: Blood measurement
Sponsor: Entia Ltd
Recruiting - Conditions: Motility Disorder of Intestine; Ondansetron; Small Bowel Water
Interventions: Drug: Ondansetron 8mg; Diagnostic Test: abdominal MRI; Drug: Lactulose; Drug: Placebo oral capsule
Sponsor: University of Nottingham
Recruiting - Condition: Computer Vision Syndrome
Interventions: Device: SYNC III; Device: single vision lenses
Sponsor: The Institute of Optometry, London
Recruiting - Conditions: Dysphagia; Swallowing Disorder
Intervention: Device: Cerebellar targeted rTMS
Sponsor: University of Manchester
Recruiting - Condition: Pusher Syndrome
Interventions: Device: Galvanic Vestibular Stimulation; Other: Standard Physiotherapy
Sponsors: Imperial College London; Homerton University Hospital NHS Foundation Trust
Recruiting - Condition: Allergy
Intervention: Other: Nurse Led Allergy Clinic
Sponsors: University of Edinburgh; Allergy UK
Recruiting - Condition: Caring
Intervention: Other: App
Sponsor: East and North Hertfordshire NHS Trust
Recruiting - Conditions: Atopic Dermatitis Eczema; Atopic Dermatitis; Eczema
Intervention: Other: No intervention
Sponsors: Momentum Data; Pfizer; Royal College of General Practitioners Research and Surveillance Centre
Active, not recruiting - Conditions: Cataract; Age Related Macular Degeneration; Pseudophakia; Macular Disease; Diabetic Retinopathy; Retinal Disease
Intervention: Diagnostic Test: polarization sensitivity
Sponsors: South Warwickshire NHS Foundation Trust; Aston University
Recruiting - Condition: Obesity
Intervention: Behavioral: Mindful Construal Diary
Sponsor: Birmingham City University
Completed - Condition: GLP-1 Concentration
Intervention: Dietary Supplement: Dose response of Capolac®
Sponsors: University of Bath; Arla Foods
Recruiting - Conditions: Axial Spondyloarthritis; Crohn Disease
Intervention: Diagnostic Test: MRE review for axSpA
Sponsors: Cambridge University Hospitals NHS Foundation Trust; Merck Sharp & Dohme Corp.
Not yet recruiting - Condition: HIV-1-infection
Interventions: Biological: ConM SOSIP; Biological: EDC ConM SOSIP; Biological: ConS UFO; Biological: EDC ConS UFO; Biological: Mosaic SOSIPs
Sponsor: Imperial College London
Not yet recruiting - Condition: Primary Raynaud Phenomenon
Interventions: Dietary Supplement: High Flavanol Cocoa extract; Dietary Supplement: Alkalised cocoa
Sponsor: University of Nottingham
Recruiting - Condition: Atrial Fibrillation
Intervention: Device: Device: RhythmPadBP
Sponsor: Cardiocity Limited
Recruiting - Condition: Portion Size
Intervention: Behavioral: portion size
Sponsors: University of Liverpool; Medical Research Council
Completed - Conditions: Cochlear Implants; Hearing Preservation
Intervention: Procedure: Electrocochlography
Sponsors: Cambridge University Hospitals NHS Foundation Trust; University of Cambridge
Recruiting - Condition: Endothelial Dysfunction
Interventions: Other: Water; Other: Red Wine; Other: Green Tea; Other: Orange Juice
Sponsor: University of the Highlands and Islands
Completed - Conditions: Mood; Cognitive Change
Interventions: Dietary Supplement: Bio-Kult; Other: Placebo
Sponsor: University of Oxford
Recruiting - Condition: Primary Care
Intervention:
Sponsor: Keele University
Recruiting - Conditions: Individual Difference; Food Sensitivity; Food Preferences
Interventions: Behavioral: Solid Model; Behavioral: Liquid Model
Sponsor: University of Reading
Recruiting - Condition: Periodontitis
Interventions: Procedure: MINST; Procedure: MIST; Diagnostic Test: GTI subgroup (Geometrical/Thermal Imaging)
Sponsor: Queen Mary University of London
Recruiting - Condition: Muscle Atrophy
Intervention: Other: Lower limb immobilisation (leg brace) with varying levels of protein intake
Sponsor: University of Exeter
Recruiting - Conditions: Breastfeeding; Postnatal Depression; Stress, Psychological; Preterm Infant
Intervention: Other: Breastfeeding Support
Sponsor: University College, London
Recruiting - Condition: Lower Back Pain Chronic
Interventions: Behavioral: The Pain Toolkit; Behavioral: the Back Book
Sponsor: Teesside University
Recruiting - Condition: Pre Diabetes
Interventions: Dietary Supplement: Whey Protein Isolate; Dietary Supplement: Wheat Protein; Dietary Supplement: Wheat Protein with Leucine
Sponsors: University of Reading; Barnham Benevolent Foundation; Jason and Daphne Mermikides Charitable Trust
Not yet recruiting - Conditions: No Dental Disease; Non-smoking
Interventions: Other: Nitrate rich beetroot juice; Other: Placebo beetroot juice
Sponsors: University of Reading; Saudi Cultural Bureau
Not yet recruiting - Condition: Visual Acuity
Interventions: Device: etafilcon a Test 1; Device: etafilcon A Test 2; Device: etafilcon A Test 3; Other: Control
Sponsor: Johnson & Johnson Vision Care, Inc.
Completed - Condition: Malocclusion, Angle Class II
Interventions: Device: Button and Bead appliance; Device: Twin Block appliance
Sponsor: University of Birmingham
Recruiting - Condition: Selenium Status
Intervention: Dietary Supplement: Selenium-fortified biscuits
Sponsors: Newcastle University; Fera Science Ltd.
Recruiting - Conditions: Neonatal Death; Prematurity
Intervention: Other: Parenteral nutrition
Sponsor: Imperial College London
Active, not recruiting - Condition: Unrecognized Condition
Intervention: Device: Optiflow
Sponsor: University Hospital Southampton NHS Foundation Trust
Completed - Condition: Ileostomy - Stoma
Interventions: Dietary Supplement: Cocoa Flavanol beverage mix; Dietary Supplement: De-xanthinated Cocoa Flavanol beverage mix
Sponsors: University of Ulster; University of California, Davis
Completed - Condition: Polyunsaturated Fatty Acid (PUFA) Status
Interventions: Dietary Supplement: Fish; Other: Control
Sponsors: University of Ulster; University of Rochester; Lund University; Ministry of Health, Republic of Seychelles
Completed - Conditions: Peer Review, Publishing; Completeness of Reporting
Interventions: Behavioral: Evaluation of reporting inconsistencies; Behavioral: Standard Peer Review.
Sponsors: Universitat Politècnica de Catalunya; University of Liverpool; The BMJ
Completed - Condition: Whooping Cough
Interventions: Biological: Bordetella Pertussis B1917; Drug: Azithromycin 500 mg; Other: Sterile Saline
Sponsors: University of Southampton; Public Health England; University Hospital Southampton NHS Foundation Trust
Recruiting - Condition: Overweight and Obesity
Interventions: Behavioral: Satisfying rehearsal task; Behavioral: Dissatisfying rehearsal task; Behavioral: Neutral rehearsal
Sponsor: University of Liverpool
Completed - Condition: Exercise
Interventions: Other: Regular carbohydrate feeding; Other: Single carbohydrate bolus
Sponsor: University of Bath
Recruiting - Conditions: Pregnancy Related; Pregnant Women; Maternal-Fetal Relations
Intervention: Behavioral: Exercise group
Sponsors: Swansea University; European Union
Recruiting - Conditions: Lung; Disease, Interstitial, With Fibrosis; Alveolitis, Extrinsic Allergic; Bird Fancier's Lung; Idiopathic Interstitial Pneumonias; Lung Diseases, Interstitial; Idiopathic Pulmonary Fibrosis
Intervention: Diagnostic Test: Genetic profiling
Sponsors: NHS Forth Valley; University of Leicester; University of Glasgow; Newcastle University; British Lung Foundation; British Pigeon Fanciers Medical Research
Recruiting - Conditions: Spirituality; Palliative Care
Intervention: Behavioral: Chaplain visit
Sponsors: Edinburgh Napier University; Leuven University
Recruiting - Condition: Hamstring Injury
Intervention: Other: Lumbar Mobilisations
Sponsor: Teesside University
Recruiting - Conditions: Written Information; Written Info and Hearing Aid Reminder; Written Info and Planning on Hearing Aid Use; All Materials
Interventions: Other: i) provision of written information; Other: ii) the reminder; Other: ii) written behavioural plan; Other: iv) all materials
Sponsor: University of Manchester
Recruiting - Condition: Mouth, Edentulous
Intervention: Other: Augmented Reality Video
Sponsor: University of Leeds
Recruiting - Condition: Influenza Vaccines
Intervention: Biological: Live attenuated influenza vaccine (LAIV)
Sponsors: Imperial College London; Public Health England
Completed - Condition: Visual Acuity
Interventions: Diagnostic Test: Local Anesthesia; Diagnostic Test: Placebo
Sponsor: Johnson & Johnson Vision Care, Inc.
Completed - Conditions: Sedentary Lifestyle; Physical Activity
Interventions: Behavioral: Education and training sessions; Behavioral: Support emails; Behavioral: Team leader training; Device: Height-adjustable workstation
Sponsors: Liverpool John Moores University; University of Liverpool; University of Leicester; The University of Queensland
Active, not recruiting - Condition: Emotion Regulation
Interventions: Device: Interactive toy prototype; Device: Non-interactive toy prototype
Sponsors: University College, London; Anna Freud National Centre for Children and Families; University of California, Santa Cruz; Committee for Children (USA)
Recruiting - Condition: Portion Size
Intervention: Behavioral: portion size
Sponsors: University of Liverpool; Medical Research Council
Completed - Condition: Exercise
Interventions: Dietary Supplement: Glucose-maltodextrin; Dietary Supplement: Fructose-maltodextrin; Dietary Supplement: Fructose-maltodextrin hydrogel
Sponsors: University of Bath; University of Birmingham
Recruiting - Conditions: Meningococcal Infections; Pneumococcal Infections
Interventions: Biological: NeisVacC (Meningococcal C conjugate vaccine); Biological: Menjugate (Meningococcal C conjugate vaccine)
Sponsors: Public Health England; Institute of Child Health; National Institute of Biological Standards and Control
Completed - Condition: Haemophilus Infections
Intervention:
Sponsor: Public Health England
Completed - Conditions: Diabetes Mellitus, Type 2; Hyperglycemia, Postprandial; Physical Activity; Glucose Intolerance
Interventions: Behavioral: Physical activity; Dietary Supplement: Meal
Sponsor: University of Birmingham
Completed - Condition: RSV Infection
Intervention: Biological: RSV A Memphis 37
Sponsor: Imperial College London
Recruiting - Conditions: Overactive Bladder; Detrusor, Overactive
Intervention: Other: TPTNS
Sponsors: NHS Greater Glasgow and Clyde; University of Glasgow; Glasgow Caledonian University
Recruiting - Conditions: Metabolic Ketosis; Cognitive Impairments, Mild
Interventions: Other: Coconut oil; Other: Sunflower oil
Sponsors: Bournemouth University; Dorset HealthCare University NHS Foundation Trust
Not yet recruiting - Condition: Inflammatory Bowel Diseases
Intervention: Other: Interview
Sponsor: The Royal Wolverhampton Hospitals NHS Trust
Recruiting - Condition: Cervical Cancer
Intervention: Diagnostic Test: CINtec PLUS
Sponsors: Western Health and Social Care Trust; Roche Pharma AG
Not yet recruiting - Condition: Pregnancy
Intervention:
Sponsor: SPD Development Company Limited
Recruiting - Condition: Education, Medical
Intervention: Other: ARCP Process
Sponsors: University College Hospital Galway; The Association of Surgeons in Training
Completed - Conditions: Chronic Pain; Cesarean Section Complications
Intervention: Procedure: Caesarean Section
Sponsor: Royal Infirmary of Edinburgh
Recruiting - Conditions: Inflammation; Obesity; Inflammatory Response; Cardiovascular Diseases; Overweight
Interventions: Dietary Supplement: SFA-Rich Meal; Dietary Supplement: MUFA-Rich Meal
Sponsor: Loughborough University
Recruiting - Conditions: Anesthesia; Rib Fractures
Interventions: Procedure: Serratus Anterior Plane Catheter; Procedure: Thoracic Epidural Catheter
Sponsor: Imperial College London
Recruiting - The Effect of Pain Education on Multidisciplinary Healthcare Students' Understanding of Chronic PainCondition: Knowledge, Attitudes, Practice
Interventions: Other: Pain neuroscience education; Other: Red flag education
Sponsors: Teesside University; Northumbria University; Glasgow Caledonian University; University of Nottingham; Leeds Beckett University; University of Limerick; Robert Gordon University; University College Dublin; University of Ulster; University College Cork; University of Notre Dame Australia
Recruiting - Condition: Tick Bites
Intervention: Other: Citrepel (Insect Repellent) EPA Reg. No. 84878-2
Sponsor: ARCTEC
Recruiting - Condition: Muscle Damage
Interventions: Device: Custom fitted compression garments (CF); Device: Standard-sized compression garments (SSG); Procedure: Sham ultrasound (CON)
Sponsor: St Mary's University College
Completed - Conditions: Gingivitis; Dental Plaque
Interventions: Other: Sodium bicarbonate; Other: Control Dentifrice
Sponsor: GlaxoSmithKline
Active, not recruiting - Condition: Pre Diabetes
Interventions: Other: DNA-based dietary intervention; Other: DNA-based dietary intervention using an app; Other: Control arm
Sponsors: Imperial College London; DnaNudge Ltd
Recruiting - Condition: Prostate Neoplasm
Intervention:
Sponsors: Imperial College London; Imperial College Healthcare NHS Trust
Recruiting - Conditions: Kidney Transplant; Complications; Obesity; Physical Activity; Weight Gain; Health Behavior
Intervention: Other: ExeRTiOn
Sponsors: King's College Hospital NHS Trust; Kidney Research U.K.
Recruiting - Condition: Aerobic Capacity
Interventions: Dietary Supplement: 500mg of Aronox® >40% polyphenol aronia extract; Other: Placebo
Sponsors: Northumbria University; Naturex
Recruiting - Condition: Hepatitis C
Intervention: Behavioral: Respondent Driven Sampling
Sponsors: NHS Tayside; University of Dundee
Enrolling by invitation - Condition: Muscle Damage
Interventions: Dietary Supplement: 500mg of Aronox® >40% polyphenol aronia extract; Other: Placebo
Sponsors: Northumbria University; Naturex SA
Recruiting - Condition: Auditory Processing Disorder
Intervention: Device: Bone-conduction headset
Sponsor: Children's Hearing Evaluation and Amplification Resource, Ltd.
Not yet recruiting - Condition: Subacromial Impingement Syndrome
Intervention: Procedure: Subacromial Injection
Sponsor: Aneurin Bevan University Health Board
Recruiting - Conditions: Heart Failure; Diffuse Fibrosis; Focal Fibrosis; Arrythmia
Intervention:
Sponsor: University Hospital Southampton NHS Foundation Trust
Recruiting - Conditions: Cognitive Change; Stress, Psychological; Mood
Interventions: Dietary Supplement: Avena sativa; Dietary Supplement: Placebo
Sponsors: Northumbria University; Anklam Extrakt
Recruiting - Condition: Closed Fracture of Shaft of Humerus
Interventions: Procedure: Operative; Device: Humeral brace
Sponsors: Royal Infirmary of Edinburgh; NHS Lothian; University of Edinburgh
Recruiting - Condition: Exercise Performance
Interventions: Other: Active Nitrate Bar; Other: Placebo Bar
Sponsor: PepsiCo Global R&D
Completed - Condition: Staff Attitude
Intervention: Other: No Intervention
Sponsors: Bournemouth University; Royal Bournemouth Hospital
Recruiting - Condition: Eccentric Hip Adduction Strength
Intervention: Other: Copenhagen adductor exercise
Sponsors: University of Bath; Copenhagen University Hospital, Hvidovre
Completed - Condition: Oocyte Competence
Intervention: Other: Image acquisition and analysis
Sponsors: Center for Reproductive an Genetic Health; University College, London
Not yet recruiting - Condition: Autism Spectrum Disorder
Interventions: Drug: AZD7325_10; Drug: AZD7325_20; Drug: Placebo
Sponsor: King's College London
Recruiting - Condition: Physical Activity
Intervention: Behavioral: Mindfulness for Physical Activity
Sponsor: Liverpool John Moores University
Completed - Condition: Diabetes Mellitus, Type 2
Intervention: Behavioral: Best Possible Self
Sponsor: Liverpool John Moores University
Recruiting - Conditions: Diabetes Mellitus; Obesity
Interventions: Drug: Y14; Drug: Placebo
Sponsors: Imperial College London; Medical Research Council; Covance
Completed - Conditions: Osteoarthritis, Knee; Pain, Joint
Interventions: Behavioral: Exercise; Other: analgesic optimisation
Sponsor: University of Nottingham
Recruiting - Conditions: Leg Length Discrepancy; Leg Length Difference
Intervention: Device: LIV 30 Hz
Sponsor: University College, London
Recruiting - Condition: Family Caregivers
Intervention:
Sponsor: University of Manchester
Recruiting - Conditions: Obesity; Taste Sensitivity
Intervention: Other: No Intervention
Sponsor: St Mary's University College
Recruiting - Conditions: Stillbirth; Fetal Death; Fetal Growth Retardation; Small for Gestational Age; Fetal Growth Restriction; Perinatal Death; Intrauterine Growth Restriction
Intervention:
Sponsor: Oxford University Hospitals NHS Trust
Recruiting - Condition: Chronic Low Back Pain
Intervention: Behavioral: Psychodynamic Interpersonal Therapy (PIT)
Sponsor: Charlotte Morgan
Active, not recruiting - Condition: Airway Obstruction
Intervention: Other: Airway Assessment
Sponsor: University Hospitals Coventry and Warwickshire NHS Trust
Recruiting - Condition: Ultrasound Imaging of Anatomical Structures
Intervention:
Sponsor: Medaphor Limited
Recruiting - Conditions: Overweight and Obesity; Diet Modification; Body Weight
Interventions: Other: isomaltulose (Palatinose(TM); Other: Sucrose
Sponsor: Beneo-Institute
Completed - Condition: Interpersonal Trauma
Intervention: Other: Semi-structured interviews
Sponsor: NHS Tayside
Completed - Conditions: Acute Aortic Syndrome; Aortic Dissection; Penetrating Aortic Ulcer; Intramural Hematoma
Interventions: Diagnostic Test: 18F Sodium Fluoride Positron Emission Tomography / Computed Tomography; Diagnostic Test: CT Aortic Angiogram; Diagnostic Test: Aortic MRI
Sponsors: University of Edinburgh; NHS Lothian; British Heart Foundation
Recruiting - Condition: Cystic Fibrosis
Interventions: Other: Oral Glucose Tolerance Test (OGTT) assessment arm; Other: Mixed meal test evaluation test arm
Sponsor: Liverpool Heart and Chest Hospital NHS Foundation Trust
Withdrawn - Condition: Influenza Vaccination
Intervention: Other: Communication intervention
Sponsors: University of Warwick; University Hospital Birmingham
Completed - Condition: Corneal Astigmatism
Interventions: Device: Toric intraocular MX60T lens; Other: Standard MX60 plus corneal incisions
Sponsors: Ashford and St. Peter's Hospitals NHS Trust; Bausch & Lomb Incorporated
Recruiting - Conditions: Dementia Alzheimers; Dementia; Dementia, Vascular; Dementia Senile
Intervention:
Sponsor: Moorfields Eye Hospital NHS Foundation Trust
Not yet recruiting - Condition: Cardiovascular Diseases
Intervention: Device: High-Flow Humidified Nasal Oxygen
Sponsor: Torbay and South Devon NHS Foundation Trust
Recruiting - Condition: Exercise Performance
Interventions: Other: Test Beet Shot; Other: Placebo Beverage
Sponsor: PepsiCo Global R&D
Completed - Condition: Asthma
Interventions: Drug: Prednisolone; Drug: Placebo oral capsule
Sponsors: NHS Greater Glasgow and Clyde; Queen's University, Belfast
Recruiting - Condition: Allergy
Intervention: Drug: Amoxicillin
Sponsor: The Leeds Teaching Hospitals NHS Trust
Completed - Condition: Overweight and Obesity
Interventions: Behavioral: Attentive eating smartphone application.; Behavioral: Standard dietary advice and text tips.
Sponsors: University of Liverpool; University of Birmingham; University of Oxford
Completed - Conditions: Sloughing Skin; Mucosal Inflammation
Intervention: Other: Treatment
Sponsors: Unilever R&D; University of Birmingham
Completed - Condition: Type1diabetes
Interventions: Behavioral: high intensity interval training; Behavioral: moderate intensity continous training
Sponsors: Liverpool John Moores University; Society for Endocrinology; Royal Liverpool University Hospital; University of Birmingham; University of Exeter
Not yet recruiting - Condition: Physical Activity
Intervention: Behavioral: Physical Education (PE) programme
Sponsors: University of Oxford; Oxford Brookes University
Active, not recruiting - Condition: Stress, Psychological
Interventions: Other: Guided Imagery Relaxation Tape; Other: Music Listening; Other: Relaxation Lighting; Other: Meditation and Relaxation Light; Other: Music and Relaxation Light; Other: Control/Silence
Sponsor: University College, London
Completed - Condition: Healed Ulcer
Intervention: Other: Intellin smart phone application
Sponsors: Natalie Garratt; Innovate UK; Gendius Limited
Enrolling by invitation - Condition: Pregnancy Testing
Intervention: Diagnostic Test: home pregnancy test
Sponsor: SPD Development Company Limited
Completed - Condition: Phantom Limb Pain
Intervention: Other: Two Point Discrimination
Sponsor: Teesside University
Recruiting - Condition: Fatty Acid Oxidation
Intervention: Other: Dietary fatty acid partitioning
Sponsor: University of Oxford
Recruiting - Conditions: Appetitive Behavior; Individual Difference; Food Sensitivity; Food Preferences
Intervention: Behavioral: Expanded Corn Snack
Sponsors: University of Reading; University of Sussex; Quadram Institute Bioscience; Unilever R&D; PepsiCo Global R&D; Mondelēz International, Inc.; Arla Foods; Mars, Inc.
Recruiting - Conditions: Human Microbiome; Eating Behavior
Interventions: Dietary Supplement: Intervention snack 1; Dietary Supplement: Intervention snack 2; Dietary Supplement: Control snack
Sponsors: King's College London; Queen Mary University of London; University of Liverpool
Recruiting - Condition: Knee Osteoarthritis
Interventions: Device: Persona TKR; Device: Attune TKR
Sponsors: University of Leeds; Zimmer Biomet
Recruiting - Condition: Physical Activity and Wellbeing
Intervention: Behavioral: Urban street greening
Sponsor: University of Manchester
Active, not recruiting - Condition: Asthma
Interventions: Diagnostic Test: Indirect bronchial challenge; Other: Sham bronchial challenge
Sponsors: University of East Anglia; University of Manchester; Asthma UK Centre for Applied Research
Completed - Conditions: Physical Activity; Diet Modification
Intervention: Other: Diet
Sponsor: University of Bath
Recruiting - Condition: Diet Modification
Interventions: Other: Improved product placement of fresh fruit and vegetables; Other: Sham comparator
Sponsors: University Hospital Southampton NHS Foundation Trust; National Institute for Health Research, United Kingdom; Medical Research Council; University of Southampton
Recruiting - Effect of Drinks Containing Fruit Polyphenol Extracts and Fibre on Postprandial Glycaemia. (Glu-MIX)Condition: Postprandial Period
Interventions: Dietary Supplement: Placebo; Dietary Supplement: Polyphenol and fibre; Dietary Supplement: Fibre
Sponsors: Lucozade Ribena Suntory; King's College London
Completed - Condition: Hypertrophy
Intervention: Other: Diet
Sponsors: University of Exeter; Quorn Foods
Recruiting - Conditions: Hyperprolactinemia; Subfertility; Subclinical hypothyroïdism
Intervention: Diagnostic Test: MRI Pituitary
Sponsor: University Hospitals Coventry and Warwickshire NHS Trust
Completed - Conditions: Inflammation; Obesity; Inflammatory Response; Cardiovascular Diseases
Intervention: Other: High Fat Diet
Sponsor: Loughborough University
Completed - Condition: Acute Cough
Interventions: Drug: Gefapixant; Drug: Placebo
Sponsor: Merck Sharp & Dohme Corp.
Terminated - Condition: PHYSICAL FITNESS
Interventions: Device: Exercise app: 7 Minute Workout Challenge; Device: Running app: One You Couch to 5K
Sponsors: University College, London; Medical Research Council
Completed - Conditions: Adolescent Behavior; Child Behavior; Parents
Intervention:
Sponsor: Institute of Child Health
Not yet recruiting - Condition: Menopause
Intervention: Dietary Supplement: Alpro soya drinks
Sponsors: University of Ulster; Alpro Foundation
Completed - Condition: Anesthesia
Intervention: Drug: Oxygen
Sponsor: University Hospital Southampton NHS Foundation Trust
Recruiting - Conditions: Child; Child Development; Health Behavior; Physical Activity
Interventions: Behavioral: Linear; Behavioral: Nonlinear
Sponsors: Liverpool John Moores University; University of Münster; University of Strathclyde; University of Otago; Victoria University; Newcastle University; University of Rome Foro Italico
Active, not recruiting - Condition: Gestational Diabetes
Interventions: Dietary Supplement: Guar gum; Dietary Supplement: Cellulose
Sponsor: Imperial College London
Recruiting - Condition: Obesity
Intervention:
Sponsor: University College, London
Recruiting - Condition: Type1diabetes
Intervention: Behavioral: Effects of the type of exercise on blood glucose concentrations
Sponsor: Liverpool John Moores University
Completed - Condition: Asthma
Intervention: Behavioral: My Asthma in School
Sponsor: Queen Mary University of London
Recruiting - Condition: Postoperative Pain
Interventions: Drug: TAP Block; Drug: Control
Sponsor: Royal Devon and Exeter NHS Foundation Trust
Recruiting - Condition: The Well Being of Parents of Children With Food Allergies
Intervention: Other: Online self-help
Sponsors: Canterbury Christ Church University; Brighton & Sussex Medical School
Enrolling by invitation - Condition: Obesity
Interventions: Other: MRI; Other: Written Consent
Sponsor: University College, London
Recruiting - Condition: Injury;Sports
Intervention:
Sponsor: Heriot-Watt University
Recruiting - Condition: Postoperative Sensitivity of Existing Dental Filling Materials
Intervention: Device: Fill-Up composite resin
Sponsor: University of Leeds
Recruiting - Condition: Behavior, Consumer
Interventions: Other: Population Sample; Other: Purposive sample
Sponsor: ThinkWell
Enrolling by invitation - Conditions: Diabetes Mellitus, Type 1; Epilepsy; Asthma; Shame; Self-Compassion; Stress; Perfectionistic Cognitions
Intervention: Other: Online self-compassion intervention
Sponsors: University of Sheffield; Sheffield Children's NHS Foundation Trust; Alder Hey Children's Hospital NHS Foundation Trust; Chesterfield Royal NHS Foundation Trust
Active, not recruiting - Conditions: Atrial Fibrillation; Heart Murmurs
Intervention: Device: Rapid Rhythm Handheld 8-lead ECG Device
Sponsors: Manchester University NHS Foundation Trust; Rapid Rhythm Ltd
Recruiting - Condition: Periodontal Diseases
Interventions: Device: Hand Instrumentation Treatment; Device: Ultrasonic Instrumentation Treatment
Sponsor: University of Glasgow
Recruiting - Conditions: Cognitive Function; Urinary Metabolites; Intestinal Microbiota
Interventions: Other: Nut components; Other: Placebo
Sponsors: Northumbria University; International Nut and Dried Fruit Council
Completed - Conditions: Behavior, Adaptive; Decision Analysis
Interventions: Behavioral: presentation order; Behavioral: alternative presentation order
Sponsor: ThinkWell
Enrolling by invitation - Condition: Behavioral Changes
Interventions: Behavioral: MCDA; Behavioral: Delphi
Sponsors: ThinkWell; London School of Hygiene and Tropical Medicine
Enrolling by invitation - Conditions: Skin Cancer; Dermatology/Skin - Other
Interventions: Device: Barco NV Digital Dermatoscope device images; Device: Standard medical photographs including dermoscopy images; Other: Clinic proforma completion
Sponsor: Barco NV
Active, not recruiting - Condition: Heart Failure
Intervention: Device: WiSE-CRT
Sponsors: Guy's and St Thomas' NHS Foundation Trust; National Institute for Health Research, United Kingdom
Recruiting - Condition: Type 2 Diabetes Mellitus
Intervention: Behavioral: Reducing/breaking prolonged sitting
Sponsors: University of Leicester; University Hospitals, Leicester; Loughborough University; Baker IDI Heart and Diabetes Institute
Recruiting - Conditions: Eating Behavior; Stress; Mood
Interventions: Dietary Supplement: Prebiotic; Dietary Supplement: Maltodextrin
Sponsors: University of Roehampton; FrieslandCampina
Recruiting - Condition: Training Group, Sensitivity
Intervention: Device: Microcurrent
Sponsors: University of Greenwich; Arc Family
Completed - Condition: Cardiac Arrest
Intervention: Device: Pad positioning according to a manufacturer's diagram
Sponsor: University Hospital Southampton NHS Foundation Trust
Completed - Condition: Orthodontic Appliance Complication
Interventions: Device: 3M Unitek Victory Series™ Superior Fit Buccal Tube with APC™ Flash-Free Adhesive. 4069-6103 / 4069-6114 / 4069-6203 / 4069-6214; Device: 3M Unitek Victory Series™ Superior Fit Buccal Tube with APC™ II Adhesive. 3069-6103 / 3069-6114 / 3069-6203 / 3069-6214
Sponsor: Guy's and St Thomas' NHS Foundation Trust
Completed - Conditions: Corneal Thickness Measurement; Epithelial Thickness Measurement; LASIK Flap Thickness Measurement; SMILE Cap Thickness Measurement
Interventions: Device: ArcScan Insight 100 very high-frequency digital ultrasound; Device: Carl Zeiss Meditec Cirrus HD OCT 5000; Device: Optovue RTVue OCT; Device: CSO MS-39 OCT
Sponsors: London Vision Clinic; Carl Zeiss Meditec AG
Not yet recruiting - Conditions: Stroke; Cerebrovascular Accident; Stress; Anxiety; Depression
Intervention: Other: Web-based Mindfulness Course
Sponsor: Glasgow Caledonian University
Recruiting - Condition: High-intensity Interval Training
Intervention: Behavioral: High-intensity interval training
Sponsor: Teesside University
Completed - Condition: Visual Acuity
Interventions: Device: Test Eye Drops; Device: Control Eye Drops
Sponsor: Johnson & Johnson Vision Care, Inc.
Completed - Conditions: Upper Respiratory Tract Infections; Virus; Virus Shedding; Pediatric ALL
Intervention: Other: Na Cl solution
Sponsor: University of Edinburgh
Recruiting - Condition: Cognitive Flexibility
Interventions: Combination Product: Sham tDCS and tyrosine depleted drink; Combination Product: Anodal tDCS and tyrosine depleted drink; Combination Product: Sham tDCS and balanced drink; Combination Product: Anodal tDCS and balanced drink
Sponsor: Sheffield Hallam University
Completed - Conditions: Skeletal Scintigraphy; FDG PET/CT
Intervention: Other: Self-administered questionnaire
Sponsors: Royal Marsden NHS Foundation Trust; City, University of London
Active, not recruiting - Conditions: Aging; Cognitive Decline
Interventions: Behavioral: Intermittent Energy Restriction; Behavioral: Chewing; Behavioral: Chewing + Intermittent Energy Restriction
Sponsors: King's College London; Medical Research Council; Mars, Incorporated
Recruiting - Conditions: Infant Formula; Growth
Interventions: Other: Modified infant formula; Other: Standard infant formula
Sponsors: Nestlé; University College, London
Recruiting - Condition: Overweight and Obesity
Interventions: Behavioral: Alternate Day Fasting; Behavioral: Continuous dietary restriction
Sponsors: University of Leeds; University of Illinois at Chicago
Completed - Condition: Repeated Sweet Food Consumption
Interventions: Behavioral: Sweet food consumption; Behavioral: Non-sweet food consumption
Sponsors: Bournemouth University; University of Bristol, UK
Recruiting - Conditions: Metabolic Disease; Immune Function; Cardiovascular Diseases; Systemic Inflammation
Interventions: Dietary Supplement: Omega 3 fatty acid; Dietary Supplement: Inulin fibre
Sponsor: Guy's and St Thomas' NHS Foundation Trust
Active, not recruiting - Condition: Atopic Dermatitis
Intervention: Device: BAY987534
Sponsor: Bayer
Recruiting - Conditions: Obesity; Anesthesia; Bariatric Surgery Candidate
Interventions: Device: Optiflow and THRIVE technique; Device: Standard anaesthetic face mask
Sponsor: Imperial College London
Recruiting - Condition: Repeated Sweet Food Consumption
Intervention: Behavioral: Sweet food consumption
Sponsors: Bournemouth University; University of Bristol, UK
Recruiting - Condition: Pregnancy
Intervention: Device: Clearblue Connected Ovulation Test System
Sponsor: SPD Development Company Limited
Completed - Condition: Carcinoma, Basal Cell
Intervention: Other: OCT Mapped
Sponsors: Michelson Diagnostics Ltd.; Skin Care Network Ltd.
Recruiting - Condition: Antimicrobial Effect
Interventions: Drug: HEXI-PREP By Clinell Wipes; Drug: Chloraprep; Drug: Placebos
Sponsor: Gama Healthcare Ltd.
Recruiting - Condition: Malocclusion
Intervention: Device: Carestream 3600 intra oral scan
Sponsors: King's College London; Kingston Hospital NHS Trust
Completed - Condition: Exercise Metabolism Following Ethanol Ingestion
Intervention: Dietary Supplement: Ethanol
Sponsor: University of Bath
Completed - Condition: Dysmenorrhea
Interventions: Device: Allay; Device: Placebo
Sponsors: Birmingham Women's NHS Foundation Trust; BioElectronics Corporation
Recruiting - Conditions: Biliary Colic; Cholecystitis
Interventions: Device: Senhance Assisted Cholecystectomy; Procedure: Laparoscopic Cholecystectomy
Sponsor: Imperial College London
Completed - Condition: Autism Spectrum Disorder
Interventions: Other: Social Story; Other: Standard Information
Sponsor: University of Sheffield
Recruiting - Conditions: Obesity; Diabetes
Interventions: Dietary Supplement: Milk Mineral Supplement; Dietary Supplement: Whey Protein Hydrolysate
Sponsor: University of Bath
Completed - Conditions: Obesity; Diabetes
Interventions: Dietary Supplement: Control; Dietary Supplement: Milk mineral supplement
Sponsor: University of Bath
Completed - Condition: Ankle Fracture - Medial Malleolus
Interventions: Procedure: Fixation; Procedure: Non-fixation
Sponsor: Royal Infirmary of Edinburgh
Recruiting - Conditions: Weight Management; Diabetes Mellitus, Type 2
Interventions: Behavioral: Small Talk Big Difference Immediate access training; Behavioral: Small Talk Big Difference delayed access training
Sponsors: NHS Greater Glasgow and Clyde; University of Glasgow
Completed - Conditions: High-intensity Interval Exercise; Heart Rate; Rating of Perceived Exertion; Blood Pressure; Acute Mood; Physical Activity Enjoyment
Interventions: Behavioral: Boxing; Behavioral: Stair stepping; Behavioral: Stair climbing
Sponsor: Teesside University
Completed - Condition: Smoking, Tobacco
Interventions: Device: Electron Cigarette; Device: Nicotine Replacement Patch
Sponsor: NHS Greater Glasgow and Clyde
Completed - Condition: High Altitude Cerebral Edema
Interventions: Drug: Dexamethasone; Drug: Placebo
Sponsor: University Hospitals Coventry and Warwickshire NHS Trust
Recruiting - Condition: Stuttering, Developmental
Interventions: Behavioral: Metronome-timed speech; Device: Active tDCS; Device: Sham tDCS
Sponsor: University of Oxford
Recruiting - Condition: Impaired Mitochondrial Function, Muscle Performance
Interventions: Dietary Supplement: Acipimox; Dietary Supplement: Placebo
Sponsors: University of Exeter; Royal Devon and Exeter NHS Foundation Trust
Recruiting - Conditions: Lipid Metabolism; Diabetes
Interventions: Dietary Supplement: Placebo; Dietary Supplement: Tea beverage; Dietary Supplement: Tea extract (medium concentration); Dietary Supplement: Tea extract (high concentration); Dietary Supplement: High fat liquid meal challenge
Sponsors: University of Bath; Lucozade Ribena Suntory
Completed - Condition: Influenza A
Interventions: Drug: MHAA4549A; Drug: Placebo
Sponsor: Genentech, Inc.
Completed - Condition: Depressive Disorder, Major
Interventions: Other: MA; Other: DEP
Sponsors: University of Cambridge; University of Oxford; University of Glasgow; University of Sussex; King's College London; Janssen, LP; H. Lundbeck A/S; GlaxoSmithKline
Completed - Conditions: Cachexia; Cancer; Diet Modification; Physical Activity; Advanced Cancer
Interventions: Dietary Supplement: ProSure; Behavioral: Physical Exercise
Sponsors: University of Edinburgh; Marie Curie; Accord Clinical Research; NHS Lothian
Recruiting - Condition: Sarcopenia
Intervention: Diagnostic Test: DEXA scan
Sponsor: University of Bedfordshire
Recruiting - Conditions: Ventral Hernia; Abdominal Wall Defect
Intervention: Procedure: Abdominal Wall Closure Force (N).
Sponsors: University College, London; University College London Hospitals
Enrolling by invitation - Conditions: Chylothorax; Esophageal Cancer; Thoracic Duct Intra-Operative Injury
Intervention: Drug: Indocyanine Green
Sponsor: Oxford University Hospitals NHS Trust
Completed - Condition: Genitourinary Syndrome of Menopause
Interventions: Device: Photothermal Non-ablative Erbium:YAG-laser; Device: Fractional Microablative CO2-laser
Sponsors: King's College Hospital NHS Trust; Alexandra Hospital, Athens, Greece
Recruiting - Condition: Depression
Intervention: Behavioral: Google Hangout (VC) group
Sponsors: Queen's University, Belfast; AWARE NI; Northern Ireland Public Health Research Network
Completed - Conditions: Hearing Loss, Bilateral; Hearing Loss, Sensorineural
Intervention: Other: No intervention
Sponsors: Nottingham University Hospitals NHS Trust; National Institute for Health Research, United Kingdom; University of Nottingham; University of Liverpool; University of Southampton; University of East Anglia; National Cochlear Implant Users Association, United Kingdom
Recruiting - Conditions: Aerobic Exercise; Hyperglycemia; Glucose Metabolism Disorders (Including Diabetes Mellitus)
Interventions: Procedure: Steady-state hyperglycemia; Procedure: Fluctuating hyperglycemia; Behavioral: Exercise
Sponsor: University of Birmingham
Completed - Condition: Language Development
Interventions: Behavioral: Story Starters Intervention; Behavioral: Wait-list Control
Sponsor: Julian Pine
Completed - Condition: Condylar Process of Mandible Open Fracture
Intervention: Procedure: Open Reduction and Internal Fixation
Sponsor: Oxford University Hospitals NHS Trust
Recruiting - Conditions: Constipation; Diet Modification
Interventions: Dietary Supplement: Bran; Dietary Supplement: Nopal; Dietary Supplement: Psyllium
Sponsor: University of Nottingham
Completed - Conditions: Stress; Anxiety
Interventions: Dietary Supplement: Minerals + Vitamins; Dietary Supplement: Botanical A; Dietary Supplement: Botanical B; Other: Placebo
Sponsor: University of Leeds
Completed - Condition: Cancer
Intervention: Other: Hypoxia marker
Sponsor: Institute of Cancer Research, United Kingdom
Recruiting - Conditions: Congenital Disorder; Heart Diseases
Intervention: Other: Exercise Programme
Sponsor: Golden Jubilee National Hospital
Recruiting - Condition: Major Trauma
Intervention: Other: Qualitative interviews and questionnaire survey
Sponsor: Kingston University
Completed - Conditions: Neonatal Encephalopathy; Asphyxia Neonatorum; Hypoxic-Ischemic Encephalopathy
Intervention:
Sponsor: Thayyil, Sudhin
Recruiting - Condition: Spinal Cord Injuries
Intervention: Procedure: BCI-FES hand therapy
Sponsors: NHS Greater Glasgow and Clyde; University of Glasgow
Terminated - Condition: Cervical Cancer
Intervention: Other: Self-sampling
Sponsor: Western Health and Social Care Trust
Recruiting - Conditions: Aphasia; Stroke
Intervention: Behavioral: Adapted Solution Focused Brief Therapy
Sponsor: City, University of London
Recruiting - Condition: Dentin Sensitivity
Interventions: Device: CSSP Toothpaste; Device: Fluoride Toothpaste
Sponsors: Unilever R&D; University of Bristol
Completed - Condition: Medication Adherence
Intervention: Other: Medicines optimisation
Sponsors: Queen's University, Belfast; Medicines Optimisation Innovations Centre (MOIC); Association of the British Pharmacetical Industry (ABPI)
Active, not recruiting - Condition: Airway Obstruction
Interventions: Other: Porcine model; Other: Synthetic model
Sponsor: The Royal Wolverhampton Hospitals NHS Trust
Not yet recruiting - Condition: Myopia
Interventions: Device: Methafilcon A IV; Device: Ocufilcon B; Device: Omafilcon A
Sponsor: Coopervision, Inc.
Completed - Conditions: Obesity; Diabetes
Interventions: Dietary Supplement: Calcium Citrate; Dietary Supplement: Milk Mineral Supplement; Dietary Supplement: Whey Protein Hydrolysate
Sponsor: University of Bath
Completed - Conditions: Aging; Cognitive Decline
Interventions: Dietary Supplement: Efamol Active 50+; Behavioral: Aerobic exercise; Dietary Supplement: Placebo multinutrient
Sponsors: Bournemouth University; Efamol Ltd; Sylvia Waddilove Foundation
Completed - Conditions: Retention; Compliance; Orthodontic; Periodontal Health
Intervention: Other: Electronic reminder
Sponsor: Queen Mary University of London
Active, not recruiting - Condition: Biological Aging
Interventions: Other: Catechin Cohort 1; Other: Curcuminoid Cohort 2; Other: Flavonoid Cohort 3
Sponsor: Abbott Nutrition
Recruiting - Condition: Hyperlipidemia
Interventions: Dietary Supplement: Delphinidin type anthocyanins; Dietary Supplement: Cyanidin type anthocyanins; Dietary Supplement: Placebo
Sponsor: Quadram Institute Bioscience
Active, not recruiting - Condition: Dementia
Intervention: Other: Improving Wellbeing and Health for People with Dementia (WHELD) e-learning training programme
Sponsor: King's College London
Completed - Condition: Influenza A
Intervention: Biological: Influenza A/California/04/09
Sponsors: Duke University; United States Department of Defense; Imperial College of London
Enrolling by invitation - Conditions: Visible Difference; Acceptance and Commitment Therapy; ACT; Skin Condition; Hair Condition; Craniofacial; Burns
Intervention: Behavioral: Acceptance-based self-help intervention
Sponsor: University of Sheffield
Completed - Condition: Extracellular Vesicles; Generation and Function
Interventions: Dietary Supplement: Fish oil capsules; Dietary Supplement: High-oleic safflower oil capsules
Sponsors: University of Reading; Biotechnology and Biological Sciences Research Council
Recruiting - Conditions: Down Syndrome; Patau Syndrome; Edward's Syndrome
Intervention: Procedure: Blood sample
Sponsor: Premaitha Health
Active, not recruiting - Condition: Osteo Arthritis Knee
Interventions: Other: TKR with mechanical alignment method; Other: TKR with alternative alignment method
Sponsors: Royal Devon and Exeter NHS Foundation Trust; Stryker Nordic
Recruiting - Condition: Postprandial Period
Interventions: Dietary Supplement: Blackcurrant extract (low dose); Dietary Supplement: Placebo; Dietary Supplement: Citrus extract (low dose); Dietary Supplement: Blackcurrant extract (high dose); Dietary Supplement: Blackcurrant and citrus extracts (low dose / low dose)
Sponsors: Lucozade Ribena Suntory; King's College London
Completed - Condition: Kidney Diseases
Intervention: Device: Microdialysis sampling
Sponsors: Accunea Ltd.; Hammersmith Hospitals NHS Trust; Imperial College Healthcare NHS Trust; Innovate UK
Withdrawn - Condition: Prostate Cancer
Interventions: Genetic: Genetic SNP profiling; Other: Prostate cancer screening; Procedure: Prostate biopsy
Sponsor: Institute of Cancer Research, United Kingdom
Active, not recruiting - Condition: Vaccination; Infection
Interventions: Other: Positive Affect Intervention; Other: Neutral Control Intervention; Biological: Northern Hemisphere Influenza Vaccine 2017/18 (Delivered as part of Standard Care)
Sponsors: University of Nottingham; Northumbria University
Completed - Condition: Atopic Eczema
Intervention: Diagnostic Test: Skin Testing for Atopic eczema
Sponsors: Sheffield Teaching Hospitals NHS Foundation Trust; University of Sheffield
Recruiting - Conditions: Monitoring, Physiologic; Vital Signs; Sepsis; Altered Level of Consciousness
Intervention: Device: Bodytrak
Sponsors: Inova Design Solutions Ltd; Chelsea and Westminster NHS Foundation Trust; Innovate UK
Not yet recruiting - Conditions: Colonic Polyp; Colonic Diseases; Colonic Neoplasms; Colonic Adenoma; Colonic Adenocarcinoma; Colonic Dysplasia; Colonic Carcinoma; Colonic Cancer; Colon Hyperplastic Polyp
Intervention: Device: Optical spectral reflectance and autofluorescence imaging
Sponsor: Imperial College London
Completed - Conditions: Sarcopenia; Aged; Exercise; Preoperative Care
Intervention: Behavioral: HIIT Device: ergometer
Sponsor: University of Nottingham
Completed - Conditions: Obstructive Sleep Apnoea; Primary Open Angle Glaucoma
Intervention: Other: Application of continuous positive airway pressure (CPAP)
Sponsors: Papworth Hospital NHS Foundation Trust; Hinchingbrooke Hospital NHS Trust
Terminated - Condition: Trying to Conceive Population
Intervention: Diagnostic Test: ovulation test use
Sponsor: SPD Development Company Limited
Completed - Condition: Depression
Interventions: Dietary Supplement: Wild Blueberry Powder-13g; Dietary Supplement: Placebo
Sponsors: University of Reading; Wild Blueberry Association of North America (WBANA)
Active, not recruiting - Condition: Overweight and Obesity
Interventions: Dietary Supplement: Very low calorie diet (VLCD); Other: High intensity interval training (HIIT); Other: Resistance exercise training (RET)
Sponsors: University of Nottingham; University of Birmingham
Recruiting - Condition: Diabetes Mellitus, Type 2
Intervention: Behavioral: Combined resistance exercise and walking
Sponsors: University of Portsmouth; Portsmouth Hospitals NHS Trust
Not yet recruiting - Condition: Type 2 Diabetes Mellitus With Hypoglycemia
Intervention: Drug: Humulin S
Sponsor: University of Hull
Completed - Condition: Death
Intervention: Other: Questionnaire
Sponsor: The Royal Wolverhampton Hospitals NHS Trust
Completed - Conditions: Pregnant; Sedentary Lifestyle
Intervention: Other: Exercise
Sponsors: Liverpool John Moores University; Liverpool Women's NHS Foundation Trust
Active, not recruiting - Conditions: Obesity; Weight Loss
Interventions: Other: High Fibre; Other: High Protein
Sponsor: University of Aberdeen
Recruiting - Condition: Obesity, Acceptance and Commitment Therapy, Weight Management Service
Interventions: Behavioral: Acceptance and commitment therapy; Behavioral: Treatment as usual (dietetic intervention)
Sponsors: University of Sheffield; Mid Yorkshire Hospitals NHS Trust
Withdrawn - Condition: Salmonella Typhi Infection
Intervention: Other: Salmonella Typhi (S. Typhi)
Sponsors: University of Oxford; Bill and Melinda Gates Foundation; Yale University
Active, not recruiting - Condition: Airway Management
Interventions: Device: VBM Intubating Laryngeal Tube; Device: I-Gel
Sponsor: Guy's and St Thomas' NHS Foundation Trust
Recruiting - Condition: Cognitive Development
Interventions: Other: Executive Function Intervention; Other: Active Control Group
Sponsors: University of Sheffield; University of Nottingham
Completed - Condition: Milk Intolerance
Interventions: Dietary Supplement: A2 milk 100; Dietary Supplement: A2 milk 150; Dietary Supplement: A2 milk 200; Dietary Supplement: A2 milk 250; Dietary Supplement: A1/A2 milk 100; Dietary Supplement: A1/A2 milk 150; Dietary Supplement: A1/A2 milk 200; Dietary Supplement: A1/A2 milk 250
Sponsor: University of Reading
Active, not recruiting - Condition: Inflammatory Bowel Diseases
Intervention: Behavioral: Gratitude diary
Sponsor: University of Sheffield
Completed - Condition: Child Development
Intervention:
Sponsor: University of Aberdeen
Completed - Condition: Metabolism Disorder, Glucose
Interventions: Dietary Supplement: Control; Dietary Supplement: Normal Whey protein; Dietary Supplement: Modified whey protein
Sponsor: University of Aberdeen
Completed - Condition: Atrophic Acne Scar
Interventions: Device: ELAPR002f; Device: Saline
Sponsor: Elastagen Pty Ltd
Completed - Conditions: Sarcopenia; Muscle Hypotrophy; Muscle Atrophy
Interventions: Drug: Sustanon 250; Drug: Zoladex; Other: Placebo
Sponsor: University of Nottingham
Active, not recruiting - Conditions: Epiretinal Membrane; Retinal Hemorrhage
Intervention: Device: Robot assisted surgery
Sponsor: University of Oxford
Recruiting - Conditions: Insulin Sensitivity; Insulin Resistance; Type 2 Diabetes Mellitus
Intervention: Dietary Supplement: Yakult light
Sponsors: Loughborough University; Yakult Honsha Co., LTD
Completed - Condition: Appetitive Behavior
Interventions: Other: Control; Other: Exercise
Sponsors: Loughborough University; University College, London; Rosetrees Trust; National Institute for Health Research, United Kingdom
Completed - Condition: Dietary Supplementation During Exercise
Interventions: Dietary Supplement: Placebo; Dietary Supplement: Intervention
Sponsor: University of Aberdeen
Completed - Condition: Motivation
Interventions: Behavioral: Group A Reminder; Behavioral: Group B Reminder; Behavioral: Group C Reminder; Behavioral: Group D Reminder; Behavioral: Group E Reminder; Behavioral: Group F Reminder; Behavioral: Group G Reminder; Behavioral: Group H Reminder; Behavioral: Group I Reminder
Sponsors: ThinkWell; University of Oxford; The BMJ; Queen's University, Belfast
Active, not recruiting - Conditions: Perioperative Hypertension; Hypertension
Interventions: Other: HIIT; Other: HOLD; Other: HUG
Sponsors: University of Nottingham; The Royal College of Surgeons of England; The Dunhill Medical Trust
Active, not recruiting - Condition: Speech Sound Disorder
Interventions: Behavioral: Phonological awareness training; Behavioral: Reading enjoyment training
Sponsors: University of Manchester; Economic and Social Research Council, United Kingdom; University of Liverpool
Withdrawn - Condition: Dental Implant
Intervention: Procedure: Dental implants
Sponsor: The Campbell Clinic, UK
Recruiting - Condition: Cartilage Disease
Intervention: Device: BioPoly RS Partial Resurfacing Patella Implant
Sponsor: BioPoly LLC
Recruiting - Condition: Muscular Atrophy
Intervention: Other: Lower limb immobilisation (leg brace)
Sponsor: University of Exeter
Active, not recruiting - Conditions: Pediculoses; Head Lice
Interventions: Device: Neem-based lotion plus louse comb; Device: Neem-based lotion plus grooming comb
Sponsors: Medical Entomology Centre; Leeds Health Protection Unit; PN Lee Statistics and Computing Ltd; Nelsons
Completed - Condition: Incentive
Interventions: Other: Group 1 information; Other: Group 2 information; Other: Group 3 information; Other: Group 4 information; Other: Group 5 no information; Other: Group A Reminder; Other: Group B Reminders
Sponsors: ThinkWell; The BMJ; University of Oxford; Queen's University, Belfast
Enrolling by invitation - Condition: Apparent Mineralocorticoid Excess
Intervention: Dietary Supplement: Liquorice
Sponsor: The Royal Wolverhampton Hospitals NHS Trust
Completed - Condition: Increased Overbite
Intervention: Device: Bite turbo
Sponsors: NHS Tayside; University of Dundee
Recruiting - Condition: Dentin Sensitivity
Interventions: Other: Stannous fluoride; Other: Sodium monofluorophosphate
Sponsor: GlaxoSmithKline
Completed - Condition: Myopia
Interventions: Device: narafilcon A; Device: stenfilcon A
Sponsor: Coopervision, Inc.
Completed - Condition: Orthodontics
Interventions: Procedure: Appointment intervals; Device: fixed orthodontic braces
Sponsor: King's College London
Unknown status - Condition: Atopic Eczema
Intervention: Radiation: combined ultraviolet phototherapy (NB-UVB + UVA1) vs. NB-UVB monotherapy
Sponsors: University of Dundee; NHS Tayside
Recruiting - Condition: Depression
Interventions: Behavioral: IBLT; Behavioral: IBLT control
Sponsor: University of Oxford
Active, not recruiting - Conditions: Autism; Attention Deficit Hyperactivity Disorder; Autism Spectrum Disorder
Interventions: Dietary Supplement: a2 milk; Dietary Supplement: a1 containing milk
Sponsors: Northumbria University; ESPA Research; a2 Milk Company Ltd.
Completed - Condition: Cardiovascular Disease
Interventions: Dietary Supplement: Almonds; Dietary Supplement: Muffins/Crackers
Sponsors: King's College London; Almond Board of California
Active, not recruiting - Conditions: Learning; Quality Improvement; eLearning
Interventions: Other: QI4U learning; Other: Facilitated learning; Other: QI4U and Facilitated learning
Sponsors: Chelsea and Westminster NHS Foundation Trust; National Institute for Health Research, United Kingdom; OCB Media
Completed - Condition: Tako-tsubo Cardiomyopathy
Interventions: Procedure: Magnetic resonance imaging; Biological: Acute Inflammatory Activation study; Radiation: PET CT; Behavioral: Psychological assessment
Sponsors: University of Aberdeen; NHS Grampian
Completed - Condition: Influenza, Human
Intervention: Other: Vaccine safety surveillance
Sponsors: GlaxoSmithKline; University of Surrey
Completed - Conditions: Colonic Neoplasms; Colorectal Neoplasms
Intervention: Other: Training with feedback
Sponsors: London North West Healthcare NHS Trust; University College London Hospitals
Recruiting - Condition: Vascular Diseases
Interventions: Device: electronic cigarette + 16mg nicotine & flavor; Other: electronic cigarette + 0mg nicotine & flavor; Other: Tobacco cigarette
Sponsors: University of Dundee; NHS Tayside; British Heart Foundation
Completed - Conditions: Diabetes Mellitus; Diabetic Retinopathy; Diabetic Macular Edema
Intervention:
Sponsor: Queen's University, Belfast
Completed - Conditions: Exercised Induced Asthma; Asthma
Interventions: Dietary Supplement: HOST-DM059; Dietary Supplement: Maltodextrin
Sponsors: Nottingham Trent University; University of Reading; Clasado Biosciences; Imperial College London; HOST Therabiomics; The John van Geest Cancer Research Centre
Recruiting - Conditions: Breast Cancer; Breast Disease
Interventions: Other: Intervention A - Behavioural Regulation; Other: Intervention B - Priority
Sponsors: Imperial College Healthcare NHS Trust; Imperial College London
Terminated - Condition: Psoriatic Arthritis
Intervention: Drug: Secukinumab
Sponsors: University of Liverpool; Novartis
Active, not recruiting - Condition: Diabetes Mellitus, Type 2
Intervention: Other: Tinned mackerel fish
Sponsor: University of Aberdeen
Recruiting - Conditions: Gastrectomy; Oesophagectomy; Dumping Syndrome; Hypoglycaemia
Interventions: Drug: Somatostatin; Drug: Rifaximin
Sponsor: Cambridge University Hospitals NHS Foundation Trust
Terminated - Condition: Gastrointestinal Haemorrhage
Interventions: Device: PuraStat®; Procedure: Electrocautery
Sponsor: Portsmouth Hospitals NHS Trust
Completed - Condition: Osteoporosis
Intervention: Dietary Supplement: selenase (selenium)
Sponsors: Sheffield Teaching Hospitals NHS Foundation Trust; National Institute for Health Research, United Kingdom; University of Sheffield
Active, not recruiting - Condition: Breast Cancer
Intervention:
Sponsors: University of Dundee; NHS Tayside; University of St Andrews
Completed - Conditions: Ulcerative Colitis; Crohn's Colitis
Intervention: Other: Chromoendoscopy
Sponsor: Portsmouth Hospitals NHS Trust
Completed - Condition: Anterior Cruciate Ligament Rupture
Interventions: Procedure: Flexible reamers; Procedure: 70-degree arthroscope
Sponsor: Royal Devon and Exeter NHS Foundation Trust
Active, not recruiting - Condition: Retinal Degeneration
Interventions: Other: Questionnaire; Other: Computerised contrast sensitivity function test
Sponsor: University of Oxford
Completed - Conditions: Anorexia Nervosa; Compulsive Behavior
Interventions: Drug: N-acetyl cysteine; Drug: Placebo
Sponsor: University of Oxford
Completed - Condition: Sleep
Intervention: Behavioral: Sleep Lengthening
Sponsor: King's College London
Completed - Condition: Denture Cleansers
Interventions: Device: Denture Cleanser Daily Use Period; Device: Denture Cleanser Weekly Use Period; Other: Water
Sponsor: GlaxoSmithKline
Completed - Conditions: Pneumococcal Infections; Meningococcal Infections
Interventions: Biological: menjugate; Biological: Men C conjugate vaccine; Biological: Men C conjugate; Biological: Men C Conjugate
Sponsor: Public Health England
Completed - Conditions: Respiratory Syncytial Virus Infections; Influenza, Human
Interventions: Biological: RSV A Memphis 37; Biological: Influenza A/California/04/2009
Sponsors: Imperial College London; Medical Research Council; Wellcome Trust; National Institute for Health Research, United Kingdom
Recruiting - Condition: Smoking
Intervention:
Sponsor: St George's, University of London
Active, not recruiting - Condition: Dental Caries
Intervention: Other: Impression intervention
Sponsors: Sheffield Teaching Hospitals NHS Foundation Trust; 3M ESPE
Active, not recruiting - Conditions: Iron Deficiency; Anemia; Deficiency, Nutritional, With Poor Iron Absorption; Vitamin D Deficiency
Interventions: Dietary Supplement: Vitamin D3 supplement; Other: Placebo
Sponsors: University of Chester; Medical Research Council
Completed - Conditions: Erythromelalgia; Pain Insensitivity, Congenital; Hereditary Sensory and Autonomic Neuropathies; Chronic Pain
Intervention: Other: Observation
Sponsors: King's College London; University of Oxford; Neuroscience Technologies S.L.P
Recruiting - Conditions: Diabetes Mellitus; Obesity
Interventions: Drug: G3215; Drug: Placebo
Sponsors: Imperial College London; Medical Research Council; Covance
Completed - Conditions: Vision Disorders; Reading Disabilities
Interventions: Device: Precision tinted lenses; Device: Non-beneficial tinted lenses
Sponsor: City, University of London
Recruiting - Conditions: Diabetic Neuropathy; Neuropathic Pain; Chronic Pain; Carpal Tunnel Syndrome; Peripheral Neuropathies
Intervention: Other: Observation
Sponsors: King's College London; University of Oxford; Imperial College London; Sheffield Teaching Hospital NHS Foundation Trust
Recruiting - Condition: Menopausal Flushing
Interventions: Drug: NK3R antagonist - AZD4901; Drug: Placebo
Sponsors: Imperial College London; Medical Research Council; AstraZeneca; National Institute for Health Research, United Kingdom
Completed - Condition: Type 2 Diabetes
Intervention:
Sponsors: Natasha Duke; University of Southampton
Completed - Condition: Language Development
Interventions: Behavioral: The Reader Organisation's Shared Reading Programme; Behavioral: Shared Reading control
Sponsor: Caroline Rowland
Completed - Condition: Human Gut Microbiota
Intervention: Other: Stool sample collection
Sponsor: Quadram Institute Bioscience
Enrolling by invitation - Condition: Language Development
Interventions: Behavioral: Reading Together - Pausing for Reading; Behavioral: Reading Together - Dialogic Reading; Behavioral: Reading Together - Shared Reading Control
Sponsor: Caroline Rowland
Completed - Condition: Sedentary Lifestyle
Intervention: Behavioral: 7 days of habitual physical activity followed by 7 days of reduced physical activity
Sponsors: University of Birmingham; Maastricht University
Completed - Condition: Dental Caries
Intervention: Other: No intervention given
Sponsor: NHS Tayside
Completed - Condition: Pre-eclampsia
Intervention:
Sponsors: Oxford University Hospitals NHS Trust; University of Cambridge
Recruiting - Condition: Dietary Manipulation
Interventions: Other: Diet with a different macronutrient content A; Other: Diet with a different macronutrient content B; Other: Diet with a different macronutrient content C; Other: Interval treadmill running exercise; Other: Steady state treadmill running exercise
Sponsors: University of Birmingham; Lucozade Ribena Suntory
Completed - Condition: Pulmonary Disease
Interventions: Device: Structured Light Plethysmography; Device: Pneumotachograph Spirometry
Sponsors: Pneumacare Ltd; Cambridge University Hospitals NHS Foundation Trust; University of Cambridge
Completed - Condition: Weight
Interventions: Other: Non Nutritive Sweetened Beverages; Other: Control
Sponsors: Professor Jason Halford; American Beverage Association
Recruiting - Condition: Diabetes
Interventions: Dietary Supplement: Cambridge Weight Plan; Other: Supervised Exercise Sessions
Sponsors: University of Leicester; University Hospitals, Leicester; National Institute for Health Research, United Kingdom
Active, not recruiting - Condition: Lung Cancer
Interventions: Behavioral: Control invitation materials; Behavioral: Intervention invitation materials
Sponsors: University College, London; University College London Hospitals; Homerton University Hospital NHS Foundation Trust
Active, not recruiting - Conditions: Vitamin D Deficiency; Osteoporosis
Intervention: Dietary Supplement: Cholecalciferol (Vitamin D3)
Sponsors: Sheffield Teaching Hospitals NHS Foundation Trust; National Osteoporosis Society
Completed - Conditions: Type 2 Diabetes; Chronic Disease
Intervention: Other: No intervention
Sponsors: University Hospitals, Leicester; University of Leicester; Associacao Protectora dos Diabeticos de Portugal; The Algarve Regional Health Administration; University of Leipzig; Technische Universität Dresden; Alexander Technological Educational Institute, Thessaloniki, Greece; Diabetes Centre of Paediatrics P&A; Athens General Children's Hospital "Pan. & Aglaia Kyriakou"; Primary Care Centre Egia, San Sebastian, Spain; Basque Government Department of Public Health; Health Department of the Alto/Bajo Deba
Completed - Conditions: Prostate Cancer; Prostate Biopsy; Genetic Counselling; Genetic Markers
Intervention: Procedure: Prostate MRI and Biopsy
Sponsors: Institute of Cancer Research, United Kingdom; Royal Marsden NHS Foundation Trust; University of Cambridge; University of Oxford; Queen Mary University of London
Recruiting - Conditions: Obstructive Sleep Apnoea; Pregnancy
Interventions: Other: STOPBANG Questionnaire; Diagnostic Test: Overnight pulse oximetry; Other: Epworth Sleepiness Scale
Sponsor: City Hospitals Sunderland NHS Foundation Trust
Completed - Condition: Pregnancy
Intervention:
Sponsor: SPD Development Company Limited
Withdrawn - Conditions: Myopia; Refractive Errors
Interventions: Procedure: Small incision lenticule extraction; Drug: Tobramycin and dexamethasone; Drug: Ofloxacin; Drug: Proxymetacaine 0.5%; Drug: Oxybuprocaine 0.4%
Sponsor: London Vision Clinic
Recruiting - Conditions: Corneal Thickness Measurement; Epithelial Thickness Measurement; Anterior Eye Segment Measurements
Intervention: Device: ArcScan Insight 100 very high-frequency digital ultrasound
Sponsors: London Vision Clinic; Arcscan, Inc.
Recruiting - Condition: Rotator Cuff Tear Arthropathy
Intervention: Drug: Botulinum Toxin Type A
Sponsor: Royal Devon and Exeter NHS Foundation Trust
Completed
Clinical Trial Locations