Find Research Studies for Healthy Volunteers in Alberta

Development of a Youth Healthy Living Program With Underserved Adolescents at Rochester Alternative Learning Center

Condition: Childhood Obesity
Intervention: Behavioral: Healthy Youth Living Program
Sponsors: Mayo Clinic; Rochester Alternative Learning Center
Active, not recruiting
OSS-IRM: Optimization of MRI Sequences in Healthy Volunteers

Condition: Healthy
Intervention: Device: MRI data acquiring in healthy volunteers
Sponsor: Rennes University Hospital
Recruiting
Impact of Healthy Diet on Metabolic Health in Men and Women

Conditions: Healthy Aging; Metabolic Syndrome; Diet, Healthy
Interventions: Behavioral: Healthy Diet + Physical Activity; Behavioral: Healthy Diet
Sponsor: Örebro University, Sweden
Recruiting
Blood Sampling of Healthy Volunteers for Immunological Research

Condition: Healthy Volunteers
Intervention: Other: Blood sample
Sponsor: The Netherlands Cancer Institute
Recruiting
Turn up the HEAT - Healthy Eating and Activity Time in Summer Day Camps

Condition: Childhood Obesity
Intervention: Behavioral: Healthy Eating and Physical Activity
Sponsor: University of South Carolina
Completed
Molecular Mechanisms of Senescence Predisposing to Cancer : Exploratory Analysis on Healthy Tissues (SkinAge).

Condition: Sarcoma
Intervention: Procedure: Collection of healthy skin tissue
Sponsors: Centre Oscar Lambret; Institut de Biologie de Lille
Active, not recruiting
Whole Blood Specimen Collection From Healthy Subjects

Condition: Healthy Volunteers
Intervention: Other: Whole blood
Sponsor: Progenity, Inc.
Recruiting
Trial of IW-1701 (A Stimulator of Soluble Guanylate Cyclase (sGC)) in Healthy Volunteers

Condition: Healthy
Interventions: Drug: IW-1701; Drug: Matching Placebo
Sponsor: Cyclerion Therapeutics
Completed
Healthy Start to Feeding Intervention

Conditions: Weight, Body; Diet Habit
Intervention: Behavioral: Healthy Start to Feeding
Sponsors: University of Cincinnati; Children's Hospital Medical Center, Cincinnati
Recruiting
The Healthy Cookie Study: Understanding How Healthy Cookies Affect Fat in the Blood,

Condition: Healthy Adults
Interventions: Other: High Linoleic Acid Healthy Cookies; Other: High Oleic Acid Healthy Cookies
Sponsor: Ohio State University
Active, not recruiting
The Weaving Healthy Families Program to Promote Wellness and Resilience and Prevent Alcohol and Other Drug Abuse and Violence

Conditions: Alcohol Abuse; Drug Use; Violence, Domestic; Child Abuse; Diet Modification; Health Behavior; Health Knowledge, Attitudes, Practice; Relationship, Family; Relation, Parent-Child; Emotional Stress
Intervention: Behavioral: Weaving Healthy Families Program
Sponsors: Tulane University; National Institutes of Health (NIH)
Recruiting
Family Healthy Living Early Intervention Program

Conditions: Obesity; Health Behavior; Child Behavior; Child Obesity; Nutrition Disorders; Body Weight
Intervention: Behavioral: Family Healthy Living
Sponsors: University of Victoria; Childhood Obesity Foundation
Recruiting
Increasing Heart Healthy Behaviors in Youth With Type 1 Diabetes

Conditions: Type1diabetes; Cardiovascular Risk Factor
Intervention: Behavioral: Heart healthy intervention
Sponsor: Joslin Diabetes Center
Completed
Developing and Validating Food-based Dietary Guidelines and a Healthy Eating Index

Condition: Healthy
Intervention: Behavioral: Food-based dietary guidelines for healthier diet
Sponsors: Ethiopian Public Health Institute; Wageningen University; Food and Agriculture Organization (FAO); International Food Policy Research Institute
Not yet recruiting
Healthy Relationships and Economic Pathways

Conditions: Adolescent Relationship Abuse; Sexually Transmitted Infections; Pregnancy (Unwanted); Violence; Intentional Injury
Interventions: Behavioral: Healthy Relationships Education (HRE); Behavioral: HRE+Technology Bootcamp
Sponsors: Public Health Institute, California; American Institutes for Research
Terminated
Threonine Requirement in IBD Adults and Healthy Adult Controls

Conditions: Ulcerative Colitis; Crohn's Disease; Healthy
Intervention: Other: Threonine
Sponsors: Nestlé; The Hospital for Sick Children; Mount Sinai Hospital, Canada
Completed
Barriers and Facilitators to the Uptake of Healthy Eating Messages

Conditions: Healthy Eating; Pregnancy Related
Interventions: Other: Pregnant Women qualitative interviewing; Other: Midwives qualitative interviewing
Sponsor: Bournemouth University
Not yet recruiting
Suction Based Characterization of Healthy and Diseased Skin

Condition: Systemic Sclerosis
Interventions: Device: Measurment with Aspirational Medical Device; Device: Measurment with Cutometer MPA 580
Sponsors: Oliver Distler; Swiss Federal Institute of Technology
Completed
Healthy Body Healthy Souls: A Weight Loss Intervention Using Diabetes Prevention Program Lifestyle Intervention (DPP-LI) With Church Level Systems Change in the Marshallese Population

Condition: Weight Loss
Intervention: Behavioral: Diabetes Prevention Program Lifestyle Intervention (DPP-LI) with Healthy Bodies Healthy Souls (HBHS)
Sponsor: University of Arkansas
Enrolling by invitation
A Study To Determine The Effect Of Single-dose PF-04965842 On QTc Interval In Healthy Volunteers Compared With Placebo and Moxifloxacin

Condition: Healthy Volunteers
Interventions: Drug: PF-04965842; Drug: Moxifloxacin; Drug: Placebo
Sponsor: Pfizer
Completed
Program of Healthy Lifestyle Promotion in Yaqui Indigenous in Sonora

Conditions: Overweight; Obesity
Intervention: Behavioral: Healthy lifestyle promotion program
Sponsor: Centro de Investigación en Alimentación y Desarrollo A.C.
Active, not recruiting
Breath Analysis in Healthy Controls

Conditions: Exhaled Breath; Mass Spectrometry; Healthy Subjects
Intervention: Other: No intervention
Sponsors: University of Zurich; Swiss Federal Institute of Technology
Active, not recruiting
HEart fAiluRe evaluaTion Questionnaire

Conditions: Heart Failure; Heart Failure NYHA Class III; Heart Failure NYHA Class II; Heart Failure NYHA Class I; Heart Failure NYHA Class IV
Intervention: Other: healthy volunteers
Sponsor: John Parissis
Completed
Xenon-129 Lung Magnetic Resonance Imaging: Study of Healthy Volunteers and Participants With Pulmonary Disease

Conditions: Cystic Fibrosis; Asthma
Interventions: Drug: Xenon-129; Device: Magnetic Resonance Imaging; Device: Lung Clearance Index
Sponsor: The Hospital for Sick Children
Recruiting
[Tc-99m]-RPI-087 as an Imaging Marker in Osteoarthritis of the Knee Compared to Healthy Volunteers

Conditions: Healthy; Osteo Arthritis Knee
Intervention: Drug: [Tc-99m]-RPI-T-087 Injection
Sponsor: Reiley Pharmaceuticals Inc.
Recruiting
Impact of Consuming Plant Sterols on Endothelial Function and Blood Pressure

Conditions: Cardiovascular Diseases; Endothelial Dysfunction; Metabolic Syndrome; Diet Modification
Interventions: Dietary Supplement: plant sterols; Other: healthy diet
Sponsor: National University, Singapore
Not yet recruiting
The Healthy Cantonese Diet on Cardiometabolic Syndrome

Conditions: Cardiovascular Diseases; Cardiovascular Risk Factor; High Blood Pressure; Hypertension; Hyperlipidemias; Hyperglycemia
Interventions: Other: the healthy Cantonese diet; Other: the typical Cantonese diet
Sponsor: Sun Yat-sen University
Not yet recruiting
Community Partnering to Encourage Healthy Beverage Intake Through Child Care

Condition: Obesity
Intervention: Behavioral: Healthy Beverages in Child Care
Sponsor: University of California, San Francisco
Completed
Study to Evaluate Whether BLI-489 Can be Safely Tolerated by Healthy Subjects Given Multiple Doses

Condition: Healthy
Interventions: Drug: BLI-489; Drug: placebo
Sponsor: Wyeth is now a wholly owned subsidiary of Pfizer
Completed
Screening of Healthy Volunteers for Investigational Antimalarial Drugs, Malaria Vaccines, and Controlled Human Malaria Challenge

Condition: Malaria
Intervention:
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting
Assessment of the Biodistribution and Safety of [18F]MNI-958 in Healthy Subjects

Condition: Healthy Volunteers
Intervention: Drug: [18F]MNI-958
Sponsor: Invicro
Completed
DAS181 Single Dose Escalation Study in Healthy Adults

Condition: Healthy
Interventions: Drug: DAS181; Drug: Lactose
Sponsors: Ansun Biopharma, Inc.; National Institute of Allergy and Infectious Diseases (NIAID)
Completed
Evaluation of the Healthy Relationships Plus Program for Youth

Condition: Mental Health Wellness 1
Interventions: Behavioral: Healthy Relationships Plus Program (HRPP); Behavioral: Control Condition (Classroom Activities)
Sponsors: Centre for Addiction and Mental Health; CAMH Foundation
Completed
The Response To Ajmaline Provocation in Healthy Subjects

Conditions: Brugada Syndrome; Sudden Death
Intervention: Drug: Ajmaline
Sponsor: St George's, University of London
Recruiting
An Evaluation Of Healthy Ankle Motion And Morphology

Condition: Healthy Ankle
Interventions: Radiation: Cone Beam Computed Tomography; Radiation: Radiographs
Sponsors: Paragon 28; Focus Medical Design and Development
Active, not recruiting
Living Green and Healthy for Teens

Conditions: Healthy Lifestyle; Adolescent Behavior
Interventions: Behavioral: Aim2Be smartphone app system; Behavioral: BnLt smartphone app
Sponsors: Population Health Research Institute; Childhood Obesity Foundation; University of British Columbia; Ayogo Health Inc.; Canadian Institutes of Health Research (CIHR)
Not yet recruiting
Sample Collection From Healthy Volunteers for Assay Optimization

Condition: Healthy Volunteers
Intervention:
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting
Feasibility of Healthy Dads Healthy Kids Latino

Condition: Feasibility
Interventions: Behavioral: The Papás Saludables, Niños Saludables Program; Behavioral: The Papás Saludables, Niños Saludables Wait-list Control
Sponsors: Baylor College of Medicine; National Heart, Lung, and Blood Institute (NHLBI)
Active, not recruiting
Healthy Juntos Pilot Study

Conditions: Obesity; Activity, Motor; Diet, Healthy; Sedentary Behavior
Intervention: Behavioral: Healthy Juntos
Sponsors: University of Miami; National Heart, Lung, and Blood Institute (NHLBI)
Not yet recruiting
Recruitment and Characterization of Healthy Research Volunteers for NIMH Intramural Studies

Condition: Healthy Volunteer
Intervention:
Sponsor: National Institute of Mental Health (NIMH)
Recruiting
The Effects of Single-Pulse Transcranial Magnetic Stimulation on the Autonomic Nervous System in Healthy Adults

Condition: Healthy
Intervention: Device: Single-Pulse Transcranial Magnetic Stimulation
Sponsor: University of Minnesota - Clinical and Translational Science Institute
Completed
A Multiple Dose Study of TD-1211 in Healthy Volunteers and Patients With Opioid-Induced Constipation

Conditions: Healthy; Opioid-induced Constipation
Interventions: Drug: TD-1211; Drug: Placebo
Sponsor: Theravance Biopharma
Completed
The Effects of Antipsychotic Drugs on Brain Metabolism in Healthy Individuals

Condition: Healthy
Intervention: Drug: Olanzapine
Sponsor: Mclean Hospital
Recruiting
Collection of Peripheral Blood Mononuclear Cells (PBMCs) From Healthy People for the Expansion of T Cells for Adoptive Cell Therapy

Condition: Healthy Volunteer
Intervention:
Sponsor: National Cancer Institute (NCI)
Recruiting
The Healthy Elementary School of the Future

Conditions: Overweight; Physical Activity; Malnutrition; Child Development; Lifestyle-related Condition; Socioeconomic Difficulty
Interventions: Other: The Healthy Primary School of the Future; Behavioral: The Physical Activity School
Sponsor: Maastricht University
Enrolling by invitation
SET-Recovery/Healthy Home

Conditions: Substance-Related Disorders; Mental Health
Intervention: Behavioral: SET-R/Healthy Home
Sponsors: University of Miami; National Institute on Minority Health and Health Disparities (NIMHD)
Completed
Study of CVN424 in Healthy Subjects

Condition: Healthy
Interventions: Drug: CVN424; Drug: Placebo
Sponsor: Cerevance Beta, Inc.
Completed
Normal Breathing and Swallowing in Healthy Volunteers

Condition: Healthy
Interventions: Drug: Capsaicin; Device: Videofluoroscopic swallow study
Sponsors: University of Florida; National Institute on Deafness and Other Communication Disorders (NIDCD)
Completed
Normative Metrics of High-Resolution Anorectal Manometry With the Use of Solid-State Catheter in a Healthy Russian Cohort

Condition: Healthy Subjects
Intervention: Diagnostic Test: High-Resolution anorectal manometry with the use of solid-state catheter
Sponsors: Russian Academy of Medical Sciences; State Scientific Centre of Coloproctology, Russian Federation; Federal Research Centre of Nutrition and Biotechnology
Recruiting
A SAD/MAD to Assess the Safety, Pharmacokinetics and Pharmacodynamics of FT-4202 in Healthy Volunteers and Sickle Cell Disease Patients

Conditions: Healthy Volunteers; Sickle Cell Disease
Interventions: Drug: FT-4202/Placebo; Drug: FT-4202
Sponsors: Forma Therapeutics, Inc.; Medpace, Inc.
Recruiting
Healthy Parent Carers Feasibility Study

Condition: Health Behavior
Interventions: Behavioral: Healthy Parent Carers group programme; Behavioral: Healthy Parent Carers online resources
Sponsors: University of Exeter; University of Oxford
Active, not recruiting
A Trial to Investigate the Safety, Tolerability, and Drug Levels in Blood After Single and Multiple Doses of LEO 32731 in Healthy People

Condition: Healthy
Interventions: Drug: LEO 32731 modified release tablet; Drug: LEO 32731 blend, hard capsule; Drug: LEO 32731 API, hard capsule; Drug: LEO 32731 soft capsule; Drug: LEO 32731 gastro-resistant capsule; Drug: LEO 32731; Other: Placebo
Sponsor: LEO Pharma
Completed
Psychometric Validation of the Competitive Attention Test

Condition: Attention Deficit Hyperactivity Disorder
Interventions: Other: experience 1 : Competitive attention test in healthy participants; Other: experience 2 : Competitive attention test in patients with ADHD with no treatment; Other: experience 3 :Competitive attention test in patients with ADHD with psychostimulant treatment
Sponsor: Hospices Civils de Lyon
Not yet recruiting
Hyperpolarized Xenon-129 Lung Magnetic Resonance Imaging: Healthy Adult Volunteer Pilot Study

Condition: Healthy
Intervention:
Sponsor: The Hospital for Sick Children
Recruiting
Study of NaQuinate in Healthy Volunteers

Condition: Osteoporosis
Interventions: Drug: NaQuinate; Drug: Placebo
Sponsors: Haoma Medica Limited; Parexel
Recruiting
Chickasaw Healthy Eating Environments Research Study

Conditions: Blood Pressure; Body Weight
Intervention: Behavioral: Packed Promise for a Healthy Heart
Sponsors: Oklahoma State University Center for Health Sciences; The Chickasaw Nation; Washington State University
Recruiting
Effects of Rosuvastatin on the Immune System in Healthy Volunteers With Normal Cholesterol

Conditions: Healthy Volunteers; Statins; Immune Modulation
Intervention:
Sponsor: National Heart, Lung, and Blood Institute (NHLBI)
Completed
Pharmacokinetic Study of Benralizumab in Healthy Chinese Subjects

Condition: Healthy Subjects
Intervention: Biological: Benralizumab
Sponsor: AstraZeneca
Completed
A Study to Assess Pharmacokinetics of PF-04965842 and Its Metabolites and Effect of Probenecid in Healthy Participants

Condition: Healthy
Interventions: Drug: PF-04965842; Drug: Probenecid
Sponsor: Pfizer
Completed
A Study on the Collection of Peripheral Blood Mononuclear Cells From Healthy Volunteers for the Development of Allogeneic Cellular Immunotherapy Products

Condition: Collection of Peripheral Blood Mononuclear Cells by Means of Apheresis
Intervention: Procedure: collection of peripheral blood mononuclear cells from healthy volunteers
Sponsor: The First Affiliated Hospital with Nanjing Medical University
Recruiting
Assessment of the Biodistribution and Safety of [18F]MNI-1054

Condition: Healthy Volunteers
Intervention: Drug: [18F]MNI-1054
Sponsor: Invicro
Completed
GI-Challenge Study for Gastroparesis Patients and Healthy Controls

Condition: Gastroparesis
Intervention: Other: Observational
Sponsor: Stanford University
Recruiting
Efficacy of Fish Oil or Olive Oil Supplementation on the Health Effects of Ozone Exposure in Healthy Young Subjects

Conditions: Healthy; Dietary Supplement
Interventions: Drug: Ozone; Dietary Supplement: Fish Oil; Dietary Supplement: Olive Oil
Sponsors: University of North Carolina, Chapel Hill; Environmental Protection Agency (EPA)
Recruiting
A Study Using Healthy Volunteers Comparing Belatacept Which Has Been Manufactured By 2 Different Processes

Condition: Healthy Volunteers
Intervention: Drug: belatacept
Sponsor: Bristol-Myers Squibb
Completed
A Study to Evaluate the Effects of a Single and Multiple Oral Doses of GLPG3121 in Adult, Healthy, Male Subjects

Condition: Healthy
Interventions: Drug: GLPG3121 SAD; Drug: Placebo SAD; Drug: GLPG3121 MAD; Drug: Placebo MAD
Sponsor: Galapagos NV
Completed
Release of Nociceptin From Granulocytes in Sepsis

Conditions: Sepsis; Septic Shock; Sepsis Syndrome; Severe Sepsis
Intervention: Diagnostic Test: Septic
Sponsors: University of Leicester; The Royal College of Anaesthetists; University Hospitals, Leicester
Recruiting
A Pharmacokinetic Study of Omaveloxolone in Healthy Volunteers

Condition: Healthy
Intervention: Drug: omaveloxolone
Sponsor: Reata Pharmaceuticals, Inc.
Completed
Action Observation Based Rehabilitation of Children With Unilateral Cerebral Palsy

Conditions: Hemiplegic Cerebral Palsy; Motor Activity
Interventions: Other: AOT Pathological Model Experimental Group; Other: AOT Healthy Model Control Group
Sponsor: University of Parma
Not yet recruiting
Healthy Kids & Families: Overcoming Social, Environmental and Family Barriers to Childhood Obesity Prevention

Condition: Obesity
Interventions: Behavioral: Healthy Lifestyle; Behavioral: Positive Parenting
Sponsors: University of Massachusetts, Worcester; Oak Hill Community Development Corporation; Worcester Public Schools
Completed
In Vivo Predictive Dissolution 1

Condition: Healthy
Intervention: Diagnostic Test: MRI and concomitant perfused manometry of bowel motility
Sponsors: University of Nottingham; Food and Drug Administration (FDA); University of Michigan
Completed
Prolonged Hypoxic Breathing in Healthy Volunteers: a Safety Study

Condition: Healthy Volunteers
Intervention: Other: Inhaled Nitrogen
Sponsors: Massachusetts General Hospital; Rezoagli, Emanuele, M.D., Massachusetts General Hospital, Harvard Medical School; Ferrari, Michele, M.D., Massachusetts General Hospital, Harvard Medical School; Patel, Sarvagna, B.A., Massachusetts General Hospital, Harvard Medical School; Zapol, Warren M., M.D., Massachusetts General Hospital, Harvard Medical School; Fisher, Daniel, R.R.T., Massachusetts General Hospital, Harvard Medical School; Jain, Isha, B.A., Massachusetts General Hospital, Harvard Medical School; Mootha, Vamsi, M.D., Massachusetts General Hospital, Harvard Medical School; Harris, Stuart N., M.D., Massachusetts General Hospital, Harvard Medical School; Karaa, Amel, M.D., Massachusetts General Hospital, Harvard Medical School
Recruiting
Healthy Meals: A Restaurant-based Study to Promote Healthy and Allergy Adapted Diet

Conditions: Intervention; Food Allergy; Food Preferences; Food Intolerance; Diet Habit; Diet Modification
Intervention: Behavioral: Multicomponent intervention
Sponsors: University Rovira i Virgili; Diputació de Tarragona
Recruiting
Effect of Food on Pharmacokinetics of Salvianolic Acid A in Healthy Subjects

Condition: Healthy
Intervention: Drug: salvianolic acid A
Sponsor: Peking University First Hospital
Recruiting
The Effects of Flow Settings During High Flow Nasal Cannula for Healthy Volunteers and Adult Hypoxemia Patients

Condition: Hypoxemia
Intervention: Other: HFNC flow
Sponsors: Rush University Medical Center; Shanghai Zhongshan Hospital
Recruiting
Fatigue in Healthy Individuals

Conditions: Healthy Volunteer; Fatigue; Depression
Intervention:
Sponsor: National Institute of Nursing Research (NINR)
Completed
Safety and Immunogenicity of MSB11455 in Healthy Participants

Condition: Healthy
Interventions: Drug: MSB11455; Drug: US-Neulasta
Sponsor: Fresenius Kabi SwissBioSim GmbH
Completed
An Ascending Multiple Dose Study With VTP-43742 in Healthy Volunteers

Condition: Psoriasis
Interventions: Drug: Placebo; Drug: VTP-43742
Sponsor: Vitae Pharmaceuticals Inc., an Allergan affiliate
Completed
Semi-manual Vessel Density Analysis on Optical Coherence Tomography Angiography Images of Healthy Adults

Condition: Healthy
Intervention: Device: Optical coherence tomography angiography (Zeiss Cirrus HD OCT 5000 AngioPlex)
Sponsor: Semmelweis University
Active, not recruiting
Study to Evaluate the Respiratory Safety of Lemborexant in Adult and Elderly Healthy Subjects and Adult and Elderly Subjects With Mild Obstructive Sleep Apnea

Conditions: Obstructive Sleep Apnea; Healthy Subjects
Interventions: Drug: Placebo; Drug: Lemborexant 10 mg; Drug: Lemborexant 25 mg
Sponsors: Eisai Inc.; Purdue Pharma LP
Completed
Healthy Foods and Education to Treat Diabetes

Condition: Diabetes Mellitus
Intervention: Behavioral: Healthy food and Education/Cooking Classes
Sponsor: Johns Hopkins University
Active, not recruiting
Normal Values of Brain Natriuretic Peptide in Healthy Newborn

Condition: Reference Values of BNP in Healthy Newborn
Intervention: Procedure: Blood sample and BNP measurement
Sponsor: Instituto de Cardiología y Medicina Vascular Hospital Zambrano-Hellion Tec Salud
Completed
Pharmacokinetic/Pharmacodynamic Equivalence of MSB11455 in Healthy Subjects

Condition: Healthy
Interventions: Drug: MSB11455; Drug: Neulasta
Sponsor: Fresenius Kabi SwissBioSim GmbH
Completed
Definition and Validation of Normative Data of EndoFLIP™ Measurements in Healthy Subjects

Condition: Healthy Subjects
Intervention: Device: EndoFLIP™ System with FLIP Topography Module
Sponsor: Medtronic - MITG
Not yet recruiting
Relative Bioavailability of MN-166 (Ibudilast) in Extended Release Tablet vs. Intermediate-release Capsule in Healthy Volunteers

Condition: Healthy Volunteers
Intervention: Drug: MN-166
Sponsor: MediciNova
Active, not recruiting
Impact of Weekly Administration of Rifapentine and Isoniazid on Steady State Pharmacokinetics of Tenofovir Alafenamide in Healthy Volunteers (YODA)

Condition: Healthy Volunteers
Interventions: Drug: Vemlidy (tenofivir alafenamide); Drug: Priftin (rifapentine); Drug: Isoniazid; Dietary Supplement: Pyridoxine
Sponsor: National Institutes of Health Clinical Center (CC)
Recruiting
A Study of HNC042 in Healthy Subjects to Evaluate the Safety, Tolerability, and Pharmacokinetics.

Condition: Healthy
Interventions: Drug: HNC042 single dose; Drug: Placebo single dose; Drug: HNC042 multiple ascending doses; Drug: Placebo multiple ascending doses
Sponsor: Guangzhou Henovcom Bioscience Co. Ltd.
Completed
Prevalence of Nasal Hyperreactivity in Chronic Upper Airway Inflammation

Conditions: Hyperactivity; Chronic Rhinosinusitis (Diagnosis); Chronic Rhinitis; Upper Respiratory Disease
Intervention: Other: Questionnaire
Sponsor: Universitaire Ziekenhuizen Leuven
Recruiting
Safety and Pharmacokinetics of VNRX-5133 in the Epithelial Lining Fluid of Healthy Adult Subjects

Condition: Healthy Subjects
Intervention: Drug: VNRX-5133 + cefepime
Sponsors: VenatoRx Pharmaceuticals, Inc.; National Institutes of Health (NIH)
Completed
A Study to Evaluate Safety and Tolerability of Single Ascending Doses of Rozanolixizumab Administered by Subcutaneous Infusion in Healthy Japanese, Chinese and Caucasian Study Participants

Condition: Healthy-volunteers
Interventions: Drug: Rozanolixizumab; Drug: Placebo
Sponsor: UCB Biopharma S.P.R.L.
Recruiting
Relative Bioavailability Study of a Modified-Release Formulation of PF-06865571 in Healthy Adult Participants

Condition: Healthy Participants
Interventions: Drug: PF-06865571 400 mg Immediate Release (IR) in Fed State; Drug: PF-06865571 50 mg Modified Release (MR) in Fed State; Drug: PF-06865571 400 mg MR in Fed State; Drug: PF-06865571 400 mg MR in Fasted State
Sponsor: Pfizer
Recruiting
Linezolid in Healthy Volunteers

Condition: Healthy
Intervention: Drug: Linezolid oral tablet 300 mg/day for 5 day
Sponsor: Prince of Songkla University
Active, not recruiting
SP16 SERPIN-like Peptide Administration in Healthy Individuals

Condition: Healthy Participants
Interventions: Drug: SP16; Drug: Placebos
Sponsors: Serpin Pharma, LLC; George Mason University; Virginia Commonwealth University
Active, not recruiting
Study Evaluating Single Doses of BLI-489 in Healthy Japanese Male Subjects

Condition: Healthy
Interventions: Drug: BLI-489; Drug: Placebo
Sponsor: Wyeth is now a wholly owned subsidiary of Pfizer
Completed
Tedizolid Tissue Penetration in Diabetic Patients With Wound Infections and Healthy Volunteers Via In Vivo Microdialysis

Conditions: Diabetes; Wound Infection; Healthy Volunteers
Interventions: Drug: Tedizolid; Procedure: Microdialysis Catheter Insertion
Sponsors: Hartford Hospital; Merck Sharp & Dohme Corp.
Completed
Healthy Life Centers - Municipal Health Care Service for Lifestyle Changes - a Multicenter Intervention Study

Conditions: Musculoskeletal Disease; Obesity; Psychological Disorder
Intervention: Behavioral: Healthy Life Center
Sponsors: Norwegian University of Science and Technology; Western Norway University of Applied Sciences
Recruiting
Study of MN-166 (Ibudilast) Extended Release Tablet Formulations Compared With Capsules in Healthy Volunteers

Condition: Healthy Volunteers
Intervention: Drug: MN-166
Sponsor: MediciNova
Completed
A Pharmacokinetic Study to Assess Drug-drug Interaction Between Zanubrutinib and a Cocktail of Substrates in Healthy Subjects

Condition: Healthy Subjects
Intervention: Drug: BGB-3111 and Drug Cocktail
Sponsor: BeiGene
Completed
A Study to Evaluate the Safety and Tolerability of Raxibacumab in Healthy Subjects

Condition: Healthy
Interventions: Drug: placebo; Drug: raxibacumab
Sponsors: Human Genome Sciences Inc.; GlaxoSmithKline; Emergent BioSolutions
Completed
A 6-Week Study to Evaluate Photoallergic Skin Reaction of CCP-020 (Diacerein 1%) in Healthy Subjects

Condition: Healthy
Intervention: Drug: CCP-020 Diacerein 1% topical ointment and vehicle ointment
Sponsor: Castle Creek Pharmaceuticals, LLC
Completed
Study of the Way the Body Takes up, Distributes, and Gets Rid of ACT-541468 in Subjects With Abnormal Kidney Function Compared to Healthy Subjects

Conditions: Renal Insufficiency; Healthy
Intervention: Drug: ACT-541468
Sponsor: Idorsia Pharmaceuticals Ltd.
Not yet recruiting
Healthy Aging Resources to Thrive (HART)

Condition: Sedentary Lifestyle
Interventions: Behavioral: i-STAND; Other: Healthy Living control
Sponsors: Kaiser Permanente; National Heart, Lung, and Blood Institute (NHLBI)
Recruiting
Comparison of Serum C Type Natriuretic Peptide Levels Between Polycystic Ovary Syndrome Patients and Healthy Women

Conditions: Polycystic Ovary Syndrome; c Type Natriuretic Peptide; Menstrual Irregularity; Hyperandrogenism
Intervention: Diagnostic Test: C type natriuretic peptide
Sponsor: Near East University, Turkey
Not yet recruiting
A Study To Evaluate The Difference In iPad-Based Cognitive Video Game (Akili Interactive's Project: EVO) Performance In Amyloid-Positive Versus Amyloid-Negative Healthy Elderly Volunteers

Condition: Healthy
Interventions: Drug: Ritalin; Drug: Placebo
Sponsor: Pfizer
Completed
A Study of TG103 in Chinese Healthy Adult Subjects

Condition: Healthy
Interventions: Drug: TG103; Drug: Placebo
Sponsor: CSPC ZhongQi Pharmaceutical Technology Co., Ltd.
Not yet recruiting
Collection of Blood, Bone Marrow, and Buccal Mucosa Samples From Healthy Volunteers

Condition: Healthy Volunteers
Intervention:
Sponsor: National Heart, Lung, and Blood Institute (NHLBI)
Recruiting
DELPhI Software for the Analysis of TMS-EEG Data of Brain Functionality - a Healthy Population Norm Collection Study

Condition: Healthy
Intervention: Device: DELPhI (software as a medical device)
Sponsor: QuantalX Neuroscience
Not yet recruiting
Neurophysiological Study of Sensory and Cognitive Processes in Healthy Children and Adults

Condition: Healthy Volunteer
Interventions: Behavioral: Neurophysiological assessment; Behavioral: Neuropsychological assessment
Sponsor: University Hospital, Tours
Recruiting
A Safety Study of CC-92252 in Healthy Adult Subjects and Adult Subjects With Psoriasis

Conditions: Healthy Volunteers; Psoriasis
Interventions: Drug: CC-92252; Other: Placebo
Sponsor: Celgene
Recruiting
A Family-Based Approach To Reduce Smoking in Vietnamese Men

Conditions: Tobacco Use Cessation; Healthy Eating
Interventions: Behavioral: Tobacco LHW; Behavioral: Healthy Eating
Sponsor: University of California, San Francisco
Completed
Yeego! Healthy Eating & Gardening

Conditions: Dietary Habits; Health Behavior; Eating Behavior
Interventions: Behavioral: Behavioral Gardening Exposure; Behavioral: Healthy Eating and Gardening Curriculum; Behavioral: Family Workshops
Sponsor: Fred Hutchinson Cancer Research Center
Recruiting
Biology of the Oral Epithelium of E-Cigarette Smokers

Condition: Healthy
Intervention:
Sponsor: Weill Medical College of Cornell University
Active, not recruiting
A Clinical Pharmacology Study of Bardoxolone Methyl in Healthy Adults

Condition: Healthy Subject
Intervention: Drug: Bardoxolone methyl
Sponsor: Kyowa Kirin Co., Ltd.
Active, not recruiting
Healthy Summer Learners

Conditions: Overweight and Obesity; Academic Acheivement
Interventions: Behavioral: Healthy Summer Learners; Behavioral: 21st Century Summer Learning Center
Sponsor: University of South Carolina
Active, not recruiting
Study of PF 04965842 Effect on MATE1/2K Activity in Healthy Participants

Condition: Healthy
Interventions: Drug: Metformin; Drug: PF-04965842
Sponsor: Pfizer
Completed
Analysis of 18F-AV-1451 PET Imaging in Cognitively Healthy, MCI and AD Subjects

Condition: Alzheimer's Disease
Interventions: Drug: florbetapir F 18; Drug: 18F-AV-1451
Sponsor: Avid Radiopharmaceuticals
Completed
Compare Pharmacokinetic, Safety, Tolerability and Immunogenicity of HLX12 and Ramucirumab in Healthy Male Adult Subjects

Condition: Healthy Male Volunteers
Interventions: Biological: HLX12; Biological: Cyramza (Ramucirumab)
Sponsor: Shanghai Henlius Biotech
Not yet recruiting
Chicago Classification Normative Metrics in a Healthy Russian Cohort According to High-resolution Esophageal Manometry

Condition: Healthy
Intervention: Diagnostic Test: High resolution esophageal manometry
Sponsor: Russian Academy of Medical Sciences
Recruiting
Study to Evaluate the Effect of IW-3718 on the Pharmacokinetics of Oral Contraceptive, Levothyroxine, Glyburide, and Digoxin in Healthy Adult Volunteers

Condition: Healthy Volunteers
Interventions: Drug: Microgestin®; Drug: Levothyroxine; Drug: Glyburide; Drug: Digoxin; Drug: IW-3718
Sponsor: Ironwood Pharmaceuticals, Inc.
Completed
Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Food Effect of Single Ascending Doses of CC-92480 in Healthy Subjects

Condition: Healthy Volunteer
Intervention: Drug: CC-92480
Sponsor: Celgene
Recruiting
Adult Healthy Volunteers Study to Evaluate ALPN-101 Safety

Condition: Healthy Volunteers
Interventions: Drug: ALPN-101; Drug: Placebo
Sponsors: Alpine Immune Sciences, Inc.; Clinical Network Services (CNS) Pty Ltd
Recruiting
Placebo-Controlled Single Dose Study to Evaluate Safety and Pharmacokinetics of GMI-1359 in Healthy Volunteers

Condition: Healthy
Interventions: Drug: GMI-1359; Drug: Placebo
Sponsors: GlycoMimetics Incorporated; Celerion
Completed
Evaluation of the Healthy Lifestyle Program on Cognitive Outcomes

Condition: Obesity
Intervention: Behavioral: Evaluate Healthy Lifestyle Program on cognitive outcomes
Sponsor: Dartmouth-Hitchcock Medical Center
Recruiting
Multicultural Healthy Diet to Reduce Cognitive Decline

Conditions: Diet Modification; Cognitive Decline; Cognitive Change
Interventions: Other: Multicultural Healthy Diet; Other: Usual Diet plus Self-Care
Sponsors: Albert Einstein College of Medicine; Penn State University; University of Pennsylvania; University of Minnesota - Clinical and Translational Science Institute; National Institute on Aging (NIA)
Recruiting
A Safety Study of LY3437943 Given as a Single Injection in Healthy Participants

Condition: Healthy
Interventions: Drug: LY3437943; Drug: Placebo
Sponsor: Eli Lilly and Company
Completed
A Study of INO-A002 in Healthy Dengue Virus-naive Adults

Condition: Healthy Volunteers
Interventions: Biological: INO-A002; Device: CELLECTRA® 2000; Device: Dengue Fever Antibodies (IgG)
Sponsors: University of Pennsylvania; Inovio Pharmaceuticals
Recruiting
A Study to Assess the Safety, Tolerability, and Pharmacokinetics of E2730 in Healthy Participants

Condition: Healthy Participants
Interventions: Drug: E2730; Drug: Placebo
Sponsor: Eisai Inc.
Completed
Serum Insulin Response After Acute and Chronic Sucralose Ingestion in Healthy Volunteers With Variable Body Mass Index

Condition: Healthy
Intervention: Dietary Supplement: sucralose 48 mg (splenda)/day for ten weeks
Sponsor: Hospital General de México Dr. Eduardo Liceaga
Completed
To Evaluate the Safety and Tolerability, Pharmacokinetics, Food-effect and Pharmacodynamics of EHP-101 in Healthy Volunteers

Condition: Healthy
Interventions: Drug: EHP-101 Liquid single dose; Drug: EHP-101 Liquid multiple doses; Drug: Matching placebo
Sponsor: Emerald Health Pharmaceuticals Inc.
Active, not recruiting
Phase I Study of Pyrimethamine in Healthy Japanese and Caucasian Subjects

Condition: Toxoplasmosis
Interventions: Drug: Pyrimethamine; Drug: Calcium folinate
Sponsor: GlaxoSmithKline
Completed
Crossover Study to Evaluate the Relative Bioavailability and Palatability of a Lenvatinib Suspension Compared to the Capsule Formulation in Adult Healthy Volunteers

Condition: Healthy Volunteers
Intervention: Drug: Lenvatinib
Sponsor: Eisai Inc.
Completed
Healthy Eating ASD

Condition: Food Selectivity
Interventions: Behavioral: Pre Meal Presentation; Behavioral: Pre Meal Presentation + Modeling; Behavioral: Pre Meal Presentation + Token Economy
Sponsor: Penn State University
Recruiting
Study to Compare Pharmacokinetic Property of SYO-1644 Tab. and Nexavar Tab. in Healthy Male Volunteers

Condition: Healthy, Male
Interventions: Drug: SYO-1644; Drug: Nexavar tab
Sponsors: Samyang Biopharmaceuticals Corporation; Seoul National University Hospital
Completed
To Compare the PK and Safety of Omalizumab(CT-P39, EU-approved Xolair, and US-licensed Xolair) in Healthy Subjects

Condition: Healthy
Interventions: Biological: CT-P39; Biological: EU-approved Xolair; Biological: US-licensed Xolair
Sponsor: Celltrion
Not yet recruiting
The Study of PK, PD, Safety of Multiple Intravenous Injections of BCD-066 and Aranesp in Healthy Volunteers

Condition: Healthy
Interventions: Biological: BCD-066; Biological: Aranesp
Sponsor: Biocad
Completed
Healthy Adolescent Transitions (HAT)

Conditions: Pregnancy Prevention; Life Skill Development
Intervention: Behavioral: Healthy Adolescent Transitions (HAT) program
Sponsors: Jack Stevens; OhioHealth Research and Innovation Institute
Recruiting
A Study to Investigate the Safety of AB680 in Healthy Volunteers

Condition: Healthy Volunteers
Interventions: Drug: AB680; Other: Placebo
Sponsor: Arcus Biosciences, Inc.
Completed
A Mass Balance Study of LCB01-0371 After a Single Oral LCB01-0371 Dose With a [14C]LCB01-0371-microtrace

Condition: Healthy
Intervention: Drug: LCB01-0371 dose with a [14C]-LCB01-0371-tracer dose
Sponsor: LegoChem Biosciences, Inc
Not yet recruiting
The Study of Apelin-APJ System on Pulmonary Hypertension Patients and Healthy Subjects

Condition: Idiopathic Pulmonary Arterial Hypertension
Interventions: Drug: (Pyr1)apelin-13; Drug: Saline
Sponsor: Imperial College London
Completed
A Study of LY3002815 in Healthy Participants

Condition: Healthy
Interventions: Drug: LY3002815; Drug: Placebo
Sponsor: Eli Lilly and Company
Terminated
A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of JNJ-54767414 (Daratumumab) in Healthy Participants

Condition: Healthy
Interventions: Drug: Daratumumab; Drug: Placebo; Drug: rHuPH20
Sponsor: Janssen Research & Development, LLC
Completed
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single and Multiple Doses of CC-99677 in Healthy Adult Subjects

Condition: Healthy Volunteer
Interventions: Drug: CC-99677; Other: Placebo
Sponsor: Celgene
Recruiting
Study of Lanadelumab in Healthy Japanese and Matched Caucasian Adult Subjects

Condition: Healthy Volunteers
Intervention: Drug: Lanadelumab
Sponsor: Shire
Completed
Study of ASLAN004 in Healthy Subjects

Condition: Allergic Disorder
Intervention: Biological: ASLAN004
Sponsors: Aslan Pharmaceuticals; Iqvia Pty Ltd
Active, not recruiting
A Study to Assess the Relative Bioavailability of Gilteritinib Following a Single Dose of Gilteritinib Mini-tablet Oral Suspension and Gilteritinib Mini-tablets Compared to a Single Dose of Gilteritinib Tablet in Healthy Subjects

Condition: Healthy Volunteer
Interventions: Drug: gilteritinib; Drug: gilteritinib mini tablet
Sponsor: Astellas Pharma Global Development, Inc.
Completed
An Exploratory Evaluation of Biomarkers in Blister Fluid in Healthy Volunteers and Irradiated Skin

Conditions: Breast Cancer; Healthy Volunteer; Prostate Cancer
Intervention:
Sponsor: National Cancer Institute (NCI)
Completed
Supporting Healthy Aging by Peer Education and Support

Conditions: Health Behavior; Ageing
Intervention: Behavioral: Peer-led Health Education
Sponsors: University of Alberta; Covenant Health
Recruiting
A Study of SENS 401 in Healthy Subjects

Condition: Inner Ear Disease
Interventions: Drug: SENS-401; Drug: Placebo
Sponsors: Simbec Research; Sensorion
Completed
Safety, Tolerability and Pharmacokinetics of BI 1026706 in Healthy Chinese and Japanese Male Volunteers

Condition: Healthy
Interventions: Drug: BI 1026706; Drug: Placebo
Sponsor: Boehringer Ingelheim
Completed
Pharmacokinetics of Triferic (Ferric Pyrophosphate Citrate) Administered Intravenously to Healthy Adult Volunteers

Condition: End Stage Renal Disease
Intervention: Drug: Triferic
Sponsor: Rockwell Medical Technologies, Inc.
Completed
A Study in Healthy Adult Volunteers to Assess the Safety and Pharmacokinetics of an Investigational Imaging Product

Condition: Healthy Subjects
Interventions: Drug: ASP5354; Drug: Placebo
Sponsor: Astellas Pharma Global Development, Inc.
Completed
Cellular and Molecular Characterization of the Immune Response in Healthy NIH Employees atBaseline, and After Immunization With the H1N1 or Seasonal Influenza Vaccines

Conditions: Healthy Volunteers; Influenza
Intervention:
Sponsor: National Heart, Lung, and Blood Institute (NHLBI)
Completed
A Study to Evaluate the Effect of Saroglitazar Magnesium on the QTc Interval in Healthy Volunteers

Condition: Healthy
Interventions: Drug: Saroglitazar magnesium 4mg; Drug: Placebos; Drug: Moxifloxacin 400mg; Drug: Saroglitazar magnesium 20 mg
Sponsor: Zydus Discovery DMCC
Recruiting
VRC 610: Phase I Safety and Pharmacokinetics Study to Evaluate a Human Monoclonal Antibody (MAB) VRC-HIVMAB095-00-AB (10E8VLS) Administered Alone or Concurrently With MAB VRC- HIVMAB075-00-AB (VRC07-523LS) Via Subcutaneous Injection in Healthy Adults

Condition: Healthy Adult Immune Response
Interventions: Biological: VRC-HIVMAB95-00-AB (10E8VLS); Biological: VRC-MAB075-00-AB (VRC07-523LS)
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Suspended
Study Assessing Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of MGTA-145 in Healthy Volunteers as a Single Agent or in Combination With Plerixafor

Condition: Healthy Volunteers
Interventions: Biological: MGTA-145; Biological: plerixafor; Biological: Placebo
Sponsor: Magenta Therapeutics, Inc.
Recruiting
Healthy Eating and Active Living Taught at Home (HEALTH) Dissemination & Implementation (D&I)

Condition: Obesity
Interventions: Behavioral: Healthy Eating & Active Living Taught at Home; Behavioral: Usual Care
Sponsor: Washington University School of Medicine
Recruiting
Impact of Steady State Cobicistat and Darunavir/Cobicistat on the Pharmacokinetics and Pharmacodynamic of Oral Anticoagulants (Rivaroxaban, Apixaban) in Health Volunteers

Condition: Healthy Volunteers
Interventions: Drug: Tybost (Cobicistat); Drug: Prezcobix (Darunavir/Cobicistat); Drug: Xarelto (Rivaroxaban); Drug: Eliquis (Apixaban)
Sponsor: National Institutes of Health Clinical Center (CC)
Recruiting
Tu Salud Si Cuenta Intervention in Increasing Physical Activity and Healthy Eating Among Latino Families

Condition: Healthy Subject
Interventions: Behavioral: Behavioral Dietary Intervention; Behavioral: Behavioral Intervention
Sponsors: M.D. Anderson Cancer Center; National Cancer Institute (NCI)
Active, not recruiting
A Phase I Study of an HIV Vaccine in Healthy, HIV Uninfected Adults

Condition: Healthy
Interventions: Biological: MVA Mosaic; Biological: Placebo
Sponsors: Crucell Holland BV; US Military HIV Research Program; National Institute of Allergy and Infectious Diseases (NIAID); Beth Israel Deaconess Medical Center
Completed
Pharmacokinetic Study of Stiripentol and Its Metabolites After Multiple Dose Oral Administration in Healthy Male Volunteers

Condition: Healthy Volunteers
Intervention: Drug: Stiripentol
Sponsor: Biocodex
Recruiting
Technical Development of Interventional Cardiovascular Magnetic Resonance Imaging in Normal Volunteers

Condition: Healthy
Intervention:
Sponsor: National Heart, Lung, and Blood Institute (NHLBI)
Terminated
A Human Phase I Absolute Bioavailability Study of PRT054021 in Healthy Male Volunteers

Condition: Healthy Subjects
Intervention: Drug: Betrixaban
Sponsor: Portola Pharmaceuticals
Completed
Pharmacokinetics and Absolute Bioavailability of Fer-In-Sol and Triferic Administered Orally With Shohl's Solution in Healthy Volunteers

Condition: Iron-refractory, Iron-deficiency Anemia (IRIDA)
Interventions: Drug: Triferic; Drug: Fer-In-Sol; Drug: Shohl's solution
Sponsor: Rockwell Medical Technologies, Inc.
Completed
The Effects of Castration on the Pharmacokinetics of Zolpidem After Single Dose Administration In Men With Prostate Cancer Undergoing Androgen Deprivation Therapy Compared to Normal Healthy Females

Condition: Prostatic Neoplasms
Intervention: Drug: Zolpidem
Sponsor: National Cancer Institute (NCI)
Recruiting
Normative Metrics of High-Resolution Anorectal Manometry With the Use of Water-perfused System in a Healthy Russian Cohort

Condition: Healthy Subjects
Intervention: Diagnostic Test: High resolution anorectal manometry, water perfused catheter
Sponsors: Russian Academy of Medical Sciences; State Scientific Centre of Coloproctology, Russian Federation; Federal Research Centre of Nutrition and Biotechnology
Recruiting
Dating Matters: Strategies to Promote Healthy Teen Relationships

Conditions: Teen Dating Violence; Healthy Dating Relationship Behaviors
Interventions: Behavioral: Dating Matters Comprehensive Approach; Behavioral: Standard of Care Safe Dates Approach
Sponsors: Centers for Disease Control and Prevention; NORC at the University of Chicago; Ogilvy Public Relations; Alameda County Public Health Department; Baltimore City Health Department; Broward County Health Department; Chicago Department of Public Health
Completed
Strong Hearts: Rural CVD Prevention

Conditions: Heart Disease; Cardiovascular Disease; Sedentary Lifestyle; Overweight; Obesity
Interventions: Behavioral: Strong Hearts, Healthy Communities; Behavioral: Strong Hearts, Healthy Women
Sponsors: Cornell University; Montana State University; Tufts University; Bassett Healthcare
Active, not recruiting
Safety, Tolerability and Pharmacokinetics of 14-day Multiple Dose Titrations of TS-134 in Healthy Volunteers

Condition: Healthy Volunteers
Interventions: Drug: TS-134; Drug: Placebo
Sponsor: Taisho Pharmaceutical R&D Inc.
Completed
Hematopoietic Stem Cell Mobilization in Idiopathic CD4 Lymphocytopenia Patients and Healthy Controls for the Study of T Cell Maturation and Trafficking in Murine Models

Conditions: Idiopathic CD4 Positive; T-Lymphocytopenia
Intervention:
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting
B-Fit Intervention to Improve Brain Health

Conditions: Health Behavior; Aging
Interventions: Behavioral: Problem-solving; Behavioral: Education
Sponsor: Washington State University
Recruiting
This Study in Healthy Men Tests How Different Doses of BI 1358894 Are Taken up in the Body and How Well They Are Tolerated. The Study Also Looks at How Food Influences the Amount of BI 1358894 in the Blood

Condition: Healthy
Interventions: Drug: Placebo; Drug: BI 1358894; Drug: BI 1358894 (Test); Drug: BI 1358894 (Reference)
Sponsor: Boehringer Ingelheim
Completed
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of MRG-110 Following Intradermal Injection in Healthy Volunteers

Condition: Healthy Volunteer
Interventions: Drug: MRG-110; Drug: Placebo
Sponsor: miRagen Therapeutics, Inc.
Completed
Quantification of Myocardial Blood Flow by Positron Emission Tomography in Healthy Volunteers

Condition: Normal Healthy Volunteers Without Chronic Medical Conditions
Intervention: Procedure: cardiac PET stress test
Sponsor: Ochsner Health System
Not yet recruiting
Safety, Tolerability and Pharmacokinetics of Single Doses of TS-134 in Healthy Volunteers

Condition: Healthy Volunteers
Interventions: Drug: TS-134; Drug: Placebo
Sponsor: Taisho Pharmaceutical R&D Inc.
Completed
Your Health Matters! (Tu Salud ¡Si Cuenta!): Promoting Healthy Lifestyles in Latino Families

Conditions: Family Member; Health Status Unknown
Interventions: Other: Behavioral, Psychological or Informational Intervention; Behavioral: Patient Visit; Other: Questionnaire Administration; Other: Text Message
Sponsors: M.D. Anderson Cancer Center; National Cancer Institute (NCI); National Heart, Lung, and Blood Institute (NHLBI)
Recruiting
Health in the Right Measure: Promoting Healthy Food and Regular Physical Activity Practice for UFRJ Servers

Condition: Human
Intervention: Behavioral: Health in the right measure
Sponsor: Universidade Federal do Rio de Janeiro
Active, not recruiting
Effect of Acute and Sub-acute Administration of Gluten on Extra-intestinal and Gastrointestinal Symptoms in Healthy Subjects

Condition: Healthy Volunteers, Gluten
Interventions: Other: Gluten; Other: Placebo
Sponsor: Universitaire Ziekenhuizen Leuven
Completed
Probiotic Detection and Persistence Study

Condition: Healthy
Intervention: Biological: Probiotic Strains
Sponsors: University of Florida; Lallemand Health Solutions, Inc.
Not yet recruiting
Evaluating the Safety, Tolerability, and Pharmacokinetics of BIIB095 in Healthy Participants

Condition: Healthy Volunteer
Interventions: Drug: BIIB095; Drug: Placebo
Sponsor: Biogen
Completed
A Study To Evaluate The Effect Of Food On The Behavior Of Tofacitinib Modified Release 11 Milligram Tablets In Healthy Western And Japanese Volunteers

Condition: Healthy
Intervention: Drug: tofacitinib modified-release (MR) formulation
Sponsor: Pfizer
Completed
Evaluation of the Pharmacokinetics, Safety and Effects of NutriterraTM in Healthy Adults

Condition: Healthy
Interventions: Dietary Supplement: NutriterraTM; Dietary Supplement: Placebo
Sponsors: Nuseed Americas Inc.; Nutrasource Diagnostics Inc.
Active, not recruiting
Church, Extension and Academic Partners Empowering Healthy Families

Condition: Obesity
Interventions: Behavioral: Healthy Children, Healthy Families+ (HCHF+); Behavioral: Money Smart
Sponsors: Virginia Polytechnic Institute and State University; Virginia State University; Baptist General Convention of Virginia; Virginia Cooperative Extension; Virginia Family Nutrition Program; Virginia Tech Center for Public Health Practice and Research
Recruiting
Study to Evaluate Safety and Tolerability of ACT-709478 in Healthy Subjects

Condition: Healthy Subjects
Interventions: Drug: ACT-709478; Drug: Placebo
Sponsor: Idorsia Pharmaceuticals Ltd.
Completed
First-in-Human Trial of Single Ascending Dose, Multiple Ascending Dose and Malaria Challenge Model in Healthy Subjects

Condition: Healthy
Interventions: Drug: M5717; Drug: Placebo
Sponsor: Merck KGaA, Darmstadt, Germany
Completed
Safety and Pharmacokinetics of a Single ZMappTM Administration in Healthy Adult Volunteers

Condition: Healthy
Intervention: Drug: ZMAPP
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Withdrawn
A Study to Assess the Safety, Tolerability and Pharmacokinetics of Subcutaneous (SC) Injections of JNJ-64565111 in Healthy Male Japanese Participants and to Assess Pharmacokinetics Following Subcutaneous Injections of JNJ-64565111 in Healthy Male Caucasian Participants

Condition: Healthy
Interventions: Drug: JNJ-64565111; Drug: Placebo
Sponsor: Janssen Pharmaceutical K.K.
Terminated
Ghrelin in Healthy and Frail Older Women

Condition: Frailty
Interventions: Drug: Ghrelin Infusion - Healthy; Drug: Ghrelin Infusion - Frail; Other: Placebo Infusion -Healthy; Other: Placebo Infusion - Frail
Sponsor: University of Pennsylvania
Completed
Safety of Prasaprohyai 95%Ethanolic Extract Capsules in Healthy Volunteer

Condition: Healthy Volunteers
Intervention: Drug: Prasaprohyai
Sponsors: Thammasat University; Thai Traditional Medical Knowledge Fund
Completed
An Open Label Study to Evaluate the Pharmacokinetic Exposure of Apremilast in Healthy Subjects

Condition: Healthy Volunteers
Intervention: Drug: Apremilast
Sponsor: Celgene
Completed
Development of a New Immunotherapy Using Intramuscular Administration of Autologous Total IgG

Condition: Immunotherapy
Interventions: Biological: Part A) Healthy subjects; Biological: Part B) Advanced solid tumor
Sponsor: Ajou University School of Medicine
Recruiting
A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of JNJ-64264681 in Healthy Male and Female Participants

Condition: Healthy
Interventions: Drug: JNJ-64264681; Drug: Placebo
Sponsor: Janssen Research & Development, LLC
Completed
Feasibility and Dose Tolerability of HD-tDCS in Healthy Adults and Children With Down Syndrome

Condition: Down Syndrome
Intervention: Device: High definition transcranial direct current stimulation
Sponsor: University of Wisconsin, Madison
Recruiting
A Food-Effect Study of E7386 in Healthy Participants

Condition: Food Effect in Healthy Participants
Intervention: Drug: E7386
Sponsor: Eisai Inc.
Recruiting
Relative Bioavailability of Two Tepotinib Film-Coated Tablet Formulations in Healthy Volunteers

Condition: Healthy
Interventions: Drug: Tepotinib test (Treatment Period 1); Drug: Tepotinib reference (Treatment Period 2); Drug: Tepotinib reference (Treatment Period 1); Drug: Tepotinib test (Treatment Period 2)
Sponsor: Merck KGaA, Darmstadt, Germany
Completed
A Study of the Safety, Tolerability, and Pharmacokinetics of SPR720 in Healthy Volunteers

Condition: Healthy Volunteers
Interventions: Drug: SPR720 for SAD; Drug: Placebo for SAD; Drug: SPR720 for MAD; Drug: Placebo for MAD
Sponsors: Spero Therapeutics; Simbec Research
Recruiting
Phase 1 Single-ascending Dose Study to Evaluate Safety and Tolerability of MEDI4920 in Healthy Adults

Condition: Healthy Volunteer
Interventions: Biological: MEDI4920 3 mg; Biological: MEDI4920 10 mg; Biological: MEDI4920 30 mg; Biological: MEDI4920 100 mg; Biological: MEDI4920 300 mg; Biological: MEDI4920 1000 mg; Biological: MEDI4920 3000 mg; Other: Placebo
Sponsor: MedImmune LLC
Completed
Study Evaluating the Mass Balance And Biotransformation of Single Dose[14C] AST2818 in Chinese Healthy Male Volunteers

Condition: Healthy Male Volunteers
Intervention: Drug: [14]-AST2818
Sponsor: Allist Pharmaceuticals, Inc.
Enrolling by invitation
Evaluate the Absorption, Metabolism, And Excretion Of Orally Administered [14C] TR 701 In Healthy Adult Male Subjects

Condition: Healthy
Intervention: Drug: Human ADME
Sponsor: Trius Therapeutics LLC
Completed
A Study to Test the Safety, and Tolerability of Padsevonil in Healthy Male Japanese Study Participants

Condition: Healthy Papanese Participants
Intervention: Drug: Padsevonil
Sponsor: UCB Biopharma S.P.R.L.
Not yet recruiting
A Study to Compare the Blood Level of Bimekizumab Injected Subcutaneously Either by a Prefilled Syringe or by an Auto-injector in Adult Healthy Volunteer Participants

Condition: Healthy Volunteers
Intervention: Drug: Bimekizumab
Sponsor: UCB Biopharma S.P.R.L.
Completed
A Study of AZD4205 in Healthy Adult Subjects

Condition: Healthy Volunteers
Interventions: Drug: AZD4205; Drug: Placebo
Sponsor: Dizal (Jiangsu) Pharmaceutical Co., Ltd.
Recruiting
Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ASP1617 in Healthy Adult Non-Asian and Japanese Subjects Including Assessment of a Food Effect

Condition: Healthy Volunteers
Interventions: Drug: ASP1617; Drug: Placebo
Sponsor: Astellas Pharma Global Development, Inc.
Not yet recruiting
Pulsed Current Versus Russian Current Effects in Healthy Young Subjects.

Conditions: Healthy Young; Electric Stimulation Therapy
Interventions: Device: Pulsed current; Device: Russian Current
Sponsor: Federal University of Rio Grande do Sul
Recruiting
Staccato Loxapine Pulmonary Safety in Healthy Volunteers

Condition: Healthy
Interventions: Drug: Inhaled Placebo; Drug: Inhaled Loxapine
Sponsor: Alexza Pharmaceuticals, Inc.
Completed
Detection of miRNAs in HPA Axis Function in Healthy Subjects

Condition: Dexamethasone Effect on miRNA Profile in Healthy Humans
Intervention: Drug: Dexamethasone 4mg
Sponsor: Cedars-Sinai Medical Center
Terminated
Phase 1 Study in Healthy Subjects to Evaluate the Effect of IPI-145 on the Pharmacokinetics of Midazolam

Condition: Healthy
Interventions: Drug: IPI-145; Drug: Midazolam
Sponsor: Verastem, Inc.
Completed
Phase 2 Healthy Volunteer Study to Evaluate the Ability of PRT064445 to Reverse the Effects of Several Blood Thinner Drugs on Laboratory Tests (Module 1 of 4)

Condition: Healthy Volunteers
Interventions: Combination Product: PRT064445/Apixaban; Combination Product: Placebo/Apixaban; Drug: Placebo
Sponsor: Portola Pharmaceuticals
Completed
Effects of Multiple Doses of CS-8080 in Healthy Volunteers

Condition: Healthy
Interventions: Drug: CS-8080; Drug: placebo tablets
Sponsor: Daiichi Sankyo, Inc.
Terminated
Cadet Healthy Personal Skills Intervention Trial

Conditions: Sexual Behavior; Skills, Social; Skills, Coping
Interventions: Behavioral: Cadet Healthy Personal Skills; Behavioral: Standard Health Education
Sponsors: National Health Promotion Associates, Inc.; United States Air Force
Completed
Multiple Dose Study Of PF-05251749 In Healthy Volunteers

Conditions: Healthy Adult Subjects; Healthy Elderly Subjects
Interventions: Drug: PF-05251749; Drug: Melatonin
Sponsor: Pfizer
Completed
A Study to Investigate the Efficacy of Pain Bloc-R in Healthy Participants With Non-pathological Aches and Discomfort

Condition: Healthy
Interventions: Dietary Supplement: Pain Bloc-R; Other: Active Comparator - Acetaminophen; Other: Placebo
Sponsors: LifeSeasons Inc.; KGK Science Inc.
Completed
Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of GSK2831781 After an Intravenous (IV) Dose in Healthy Japanese and Caucasian Subjects, and a Subcutaneous (SC) Dose in Healthy Caucasian Subjects

Condition: Healthy Volunteers
Interventions: Drug: GSK2831781; Drug: Placebo
Sponsor: GlaxoSmithKline
Recruiting
IGF-1, IGFBP3, ALS Normative Ranges in Healthy Pediatric Spanish Population

Condition: IGF-1 Deficiency
Intervention:
Sponsor: Ipsen
Terminated
Assessing the Effects of a Buckwheat Beverage on Postprandial Glucose Metabolism on Healthy and T2D Individuals

Conditions: Healthy; Type2 Diabetes
Intervention: Other: Dietary Intervention
Sponsors: University of Aberdeen; NHS Grampian
Recruiting
A Trial to Evaluate the Effect of Itraconazole (ITZ), a CYP3A4 Inhibitor, on the Pharmacokinetics of the Soluble Guanylate Cyclase Stimulator, Olinciguat (IW-1701), in Healthy Volunteers

Condition: Healthy
Interventions: Drug: Olinciguat; Drug: Itraconazole
Sponsor: Cyclerion Therapeutics
Completed
Study In Healthy Subjects To Evaluate The Changes In The Protein sAPP-Alpha In Cerebrospinal Fluid Following A Single Oral Dose Of PF-04995274

Condition: Healthy
Intervention: Drug: PF-04995274
Sponsor: Pfizer
Completed
A Trial to Evaluate the Effect of Itraconazole (ITZ), a CYP3A4 Inhibitor, on the Pharmacokinetics of Praliciguat (IW-1973) in Healthy Volunteers

Condition: Healthy
Interventions: Drug: IW-1973; Drug: Itraconazole
Sponsor: Cyclerion Therapeutics
Completed
Mind Over Matter: Electronic Bladder and Bowel Continence Self-management Program

Conditions: Incontinence, Urinary; Incontinence Bowel
Intervention: Other: eMOM
Sponsor: University of Wisconsin, Madison
Recruiting
28-Day Repeat-Dose, Dose Escalation Study of 11-β Methyl Nortestosterone Dodecylcarbonate (11β-MNTDC) in Healthy Men

Conditions: Healthy Men; Male Contraception
Interventions: Drug: Placebo; Drug: 11β-methyl-nortestosterone-dodecylcarbonate
Sponsors: Health Decisions; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD); Los Angeles Biomedical Research Institute; University of Washington
Active, not recruiting
A Bronchoscopy Study to Assess the Effects of Inhaled Corticosteroids on Adult Healthy Volunteers

Condition: Healthy
Interventions: Drug: Fluticasone propionate; Device: Accuhaler
Sponsors: University Hospitals, Leicester; Genentech, Inc.
Active, not recruiting
Safety, Tolerability and Preliminary Pharmacokinetics (PK) and Pharmacodynamics (PD) of Single and Repeat Oral Doses of GSK3008356 in Healthy and Obese Subjects

Condition: Healthy Volunteers
Interventions: Drug: GSK3008356; Drug: Placebo
Sponsors: GlaxoSmithKline; Nucleus Network Ltd
Completed
Effects of Alternative Healthy Eating Index-Based Diet on Inflammatory Markers and Breast Density in Healthy Participants

Conditions: Healthy Subject; Nulliparous
Interventions: Dietary Supplement: Dietary Intervention; Procedure: Dual X-ray Absorptiometry
Sponsors: Fred Hutchinson Cancer Research Center; Breast Cancer Research Foundation; National Cancer Institute (NCI)
Not yet recruiting
The Impact of 8 Weeks of Digital Meditation Application and Healthy Eating Program on Work Stress and Health Outcomes

Conditions: Stress; Psychological; Behavioral Symptoms; Sleep; Health Behavior; Weight, Body
Interventions: Behavioral: Meditation; Behavioral: Healthy Eating; Behavioral: Meditation + healthy eating
Sponsors: University of California, San Francisco; UCSF Healthy Campus Network; Headspace, Inc
Recruiting
Study to Evaluate the Effect of Rifampin and Rifabutin With Fedratinib in Healthy Adult Subjects

Condition: Healthy Volunteers
Interventions: Drug: Fedratinib; Drug: Rifampin; Drug: Rifabutin
Sponsors: Celgene; Impact Biomedicines, Inc., a wholly owned subsidiary of Celgene Corporation
Not yet recruiting
PK of Pacritinib in Patients With Mild, Moderate, Severe Renal Impairment and ESRD Compared to Healthy Subjects

Condition: Myelofibrosis
Intervention: Drug: Pacritinib
Sponsors: CTI BioPharma; SGS S.A.
Completed
Stool Transplantation for Treatment of Insulin Resistance in Morbidly Obese Patients

Conditions: Obesity, Morbid; Insulin Resistance
Interventions: Biological: Fecal filtrate from 150 g stool from healthy lean donors; Biological: Fecal filtrate from 150 g of the recipient's own stool
Sponsors: Johane Allard; Canadian Institutes of Health Research (CIHR); MOUNT SINAI HOSPITAL; University of Toronto
Recruiting
The Safety, Tolerability, Pharmacokinetics(PK) of SR419 in Healthy Volunteers

Condition: Healthy Volunteers
Interventions: Drug: SR419; Drug: Placebo
Sponsors: SIMR (Australia) Biotech Pty Ltd; Syneos Health
Recruiting
Feasibility and Implementation of a Healthy Lifestyles Program

Conditions: Health Behavior; Quality of Life; Chronic Disease; Health Promotion; Stress; Mental Health Wellness 1
Interventions: Behavioral: Health and wellness learning sessions; Behavioral: Brainstorming group sessions; Behavioral: Individual sessions with a multidisciplinary health team; Behavioral: Health goal development; Behavioral: Physical activity and nutrition journals
Sponsor: McMaster University
Active, not recruiting
A Trial to Study the Absorption, Metabolism, and Excretion of [14C]-Praliciguat in Healthy Male Volunteers

Condition: Healthy Volunteers
Intervention: Drug: [14C]-praliciguat
Sponsor: Cyclerion Therapeutics
Completed
A Trial to Study the Absorption, Metabolism, and Excretion of [14C]-Olinciguat in Healthy Male Volunteers

Condition: Healthy Volunteers
Intervention: Drug: [14C]-olinciguat
Sponsor: Cyclerion Therapeutics
Completed
Effect of Low-Fat Food on Pexidartinib Pharmacokinetics in Healthy Volunteers

Condition: Healthy Volunteers
Interventions: Drug: Treatment A - 400 mg Fasting; Drug: Treatment B - 400 mg Fed; Drug: Treatment C - 200 mg Fed
Sponsor: Daiichi Sankyo, Inc.
Completed
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK), and Pharmacodynamics (PD) of TAK-988 in Healthy Participants

Condition: Healthy Volunteers
Interventions: Drug: TAK-988; Drug: TAK-988 Placebo
Sponsor: Takeda
Not yet recruiting
Viscosity of Fibre Predicts Cholesterol-lowering in Healthy Individuals

Conditions: Lipidemia; Healthy
Interventions: Dietary Supplement: Viscous Fibre Blend; Dietary Supplement: Psyllium; Dietary Supplement: Wheat Bran
Sponsors: St. Michael's Hospital, Toronto; Kellogg Company; University of Toronto
Completed
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of TAK-994 in Healthy Participants

Condition: Healthy Participants
Interventions: Drug: TAK-994; Drug: TAK-994 Placebo
Sponsor: Takeda
Recruiting
A 4-Day Study to Evaluate Phototoxicity of CCP-020 (Diacerein 1%) in Healthy Subjects

Condition: Healthy
Interventions: Drug: CCP-020 Diacerein 1% topical ointment; Drug: Vehicle
Sponsor: Castle Creek Pharmaceuticals, LLC
Completed
A Study of Dulaglutide in Healthy Participants

Condition: Healthy
Interventions: Drug: Dulaglutide (Reference); Drug: Dulaglutide (Test)
Sponsor: Eli Lilly and Company
Completed
Interhemispheric Interaction of Parieto-Motor Cortico-Cortical Plasticity

Condition: Healthy Volunteers
Intervention:
Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)
Withdrawn
A Single Ascending Dose Study to Evaluate the Safety and Pharmacokinetics of PU-AD in Healthy Subjects

Condition: Alzheimer's Disease
Interventions: Drug: PU-AD; Drug: Placebo
Sponsor: Samus Therapeutics, Inc.
Recruiting
School-Based Intervention Program to Promote Healthy Eating and Physical Activity

Conditions: Obesity, Childhood; Health Behavior; Physical Activity; Dietary Habits
Intervention: Behavioral: Intervention Program to Promote Healthy Eating and Physical Activity among Palestinian Female Schoolchildren
Sponsor: Hadassah Medical Organization
Active, not recruiting
Characterization of Altered Waking States of Consciousness in Healthy Humans

Condition: Altered Waking States of Consciousness in Healthy Humans
Intervention: Other: TMS/EEG
Sponsor: University of Zurich
Recruiting
The Healthy Eating With APP technologY Study

Conditions: Type 2 Diabetes Mellitus; Dietary Habits
Intervention: Behavioral: App-technology for healthy eating habits
Sponsor: Karolinska Institutet
Recruiting
Physiological Changes Exploration During the Hypnotic State

Condition: Healthy Volunteers
Intervention: Behavioral: Hypnosis
Sponsors: University Hospital, Grenoble; Commissariat à l'énergie atomique et aux énergies alternatives (CEA)
Not yet recruiting
Screening of Healthy Adults for Genetic Variations That Control Fatty Acid Processing

Condition: Healthy
Intervention:
Sponsors: Wake Forest University Health Sciences; National Center for Complementary and Integrative Health (NCCIH); Office of Dietary Supplements (ODS); University of Arizona
Recruiting
A Study To Look At Safety And Blood Concentrations After Multiple Doses Of PF-03382792 In Healthy Elderly Individuals

Condition: Healthy
Interventions: Drug: PF-03382792 0.5mg; Drug: PF-03382792 1.5 mg; Drug: PF-03382792 5 mg; Drug: PF-03382792 15 mg
Sponsor: Pfizer
Withdrawn
Lu AF82422 in Healthy Non-Japanese and Japanese Subjects and in Patients With Parkinson's Disease

Conditions: Healthy; Parkinson Disease
Interventions: Drug: Lu AF82422; Drug: Placebo
Sponsor: H. Lundbeck A/S
Recruiting
Safety, Pharmacokinetics, and Pharmacodynamics of SD-101 in Healthy Normal Males

Condition: Healthy
Interventions: Drug: SD-101; Drug: placebo
Sponsor: Dynavax Technologies Corporation
Completed
Methionine Tolerance in Healthy Human Adults

Condition: Healthy
Intervention: Dietary Supplement: methionine
Sponsors: Texas A&M University; International Council on Amino Acid Science
Completed
Safety Study of Mibefradil When Given Four Times a Day in Healthy Volunteers

Condition: Healthy
Interventions: Drug: mibefradil; Other: Placebo
Sponsors: Jazz Pharmaceuticals; Celerion; Dana-Farber Cancer Institute; LifeWatch Services, Inc.
Completed
Study to Investigate the Safety and Immunogenicity of a Tetravalent Chimeric Dengue Vaccine in Healthy Volunteers Between the Ages of 1.5 - 45 Years

Condition: Healthy
Interventions: Biological: TDV; Biological: Placebo
Sponsor: Takeda
Completed
PK and Safety Study of AG-221 in Healthy Male Japanese Subjects and Healthy Male Caucasian Subjects

Condition: Healthy
Intervention: Drug: AG-221
Sponsor: Celgene
Completed
An Evaluation of Virtual Student Health Center Among Incarcerated Juvenile Offenders

Conditions: Lack of Knowledge About Condoms and Birth Control; Adolescent Sexual Intercourse; Sexual Intercourse Without a Condom or Birth Control; Unplanned Pregnancies
Intervention: Other: "Healthy U" tablet application
Sponsors: WestEd; Oregon Youth Authority; Efficacity; The Office of Adolescent Health, HHS
Recruiting
Study to Assess the Pharmacokinetics, Pharmacodynamics, and Safety of Canagliflozin (JNJ-28431754) in Otherwise Healthy Obese Volunteers

Condition: Healthy
Interventions: Drug: Canagliflozin (JNJ-28431754); Drug: Placebo
Sponsor: Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Completed
A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of MA-0211 in Healthy Adult Subjects Including a Food Effect Cohort

Condition: Healthy Volunteers
Interventions: Drug: MA-0211; Drug: Placebo
Sponsor: Astellas Pharma Global Development, Inc.
Completed
A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ESN364 in Healthy Japanese Male and Pre- and Post-menopausal Female Subjects

Condition: Healthy Subjects
Interventions: Drug: ESN364; Drug: Placebo
Sponsor: Astellas Pharma Inc
Completed
Hip Peak Torque in Running and Jumping Activities in Healthy Active Subjects

Condition: Hip Injuries
Intervention: Other: Healthy group
Sponsor: Hvidovre University Hospital
Completed
A Study of Safety, Tolerability, and Pharmacokinetics of Multiple-Dose CC-90001 in Japanese and Caucasian Healthy Subjects

Condition: Healthy Volunteer
Intervention: Drug: CC-90001
Sponsor: Celgene
Recruiting
Collection and Distribution of Blood Samples From Healthy Donors for In Vitro Research at the NCI Frederick Cancer Research and Development Center

Condition: Healthy Donors
Intervention:
Sponsor: National Cancer Institute (NCI)
Enrolling by invitation
A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Repeat Doses of PF-06372865 in Healthy Subjects

Condition: Healthy Volunteers
Interventions: Drug: Placebo; Drug: PF-06372865
Sponsor: Pfizer
Completed
Study of a Single Dose of PRS-060 Administered by Oral Inhalation or IV Infusion in Healthy Subjects

Condition: Healthy Subjects
Interventions: Drug: PRS-060; Drug: Placebo
Sponsor: Pieris Australia Pty Ltd
Completed
A Study to Evaluate the Efficacy of Salmon Protein Hydrolysate Powder on Energy Increase and Anti-inflammatory Modulation in Healthy Males and Females

Condition: Healthy
Intervention: Dietary Supplement: Salmon Protein Hydrolysate
Sponsors: Hofseth Biocare ASA; KGK Science Inc.
Completed
Bioequivalence Study to Evaluate the Impact of Varying Crystalline Polymorph Forms for the Commercial Oral Capsule Formulation of 10-mg Lenvatinib in Healthy Volunteers

Condition: Healthy Volunteers
Intervention: Drug: Lenvatinib 10 mg
Sponsor: Eisai Inc.
Completed
Personalised Medicine in Pre-diabetes and Early Type 2 Diabetes

Conditions: Pre Diabetes; Type 2 Diabetes Mellitus
Interventions: Drug: Metformin + Healthy diet; Drug: Metformin + Personalized diet
Sponsors: Garvan Institute of Medical Research; Weizmann Institute of Science
Recruiting
Intestinal Response Patterns to Microbial Signals

Condition: CD - Crohn's Disease
Intervention: Other: Blood tests, intestinal biopsies, stool samples, environmental exposure questionnaire and FFQ questionnaire
Sponsors: Sheba Medical Center; Weizmann Institute of Science; Washington University School of Medicine; Sun Yat-sen University
Recruiting
The Feasibility of TECH: Tablet Enhancement of Cognition and Health for Healthy Adults

Condition: Healthy Adults
Intervention: Other: TECH: Tablet Enhancement of Cognition and Health
Sponsor: Assuta Hospital Systems
Recruiting
Food Effect and CYP1A2 Induction Study in Healthy Subjects

Condition: Healthy Volunteers
Interventions: Drug: Pomalidomide; Other: Caffeine; Other: Tobacco
Sponsor: Celgene
Completed
Localized Muscle Cooling on Balance in Healthy Individuals

Condition: Healthy
Intervention: Behavioral: cooling
Sponsor: King Saud University
Completed
Singe Dose, First in Human Study of PF- 06946860 in Healthy Adult Subjects

Condition: Healthy
Interventions: Biological: PF-06946860; Other: Placebo
Sponsor: Pfizer
Recruiting
A Study to Assess the Safety, Pharmacokinetics and Immunogenicity of CR8020 in Japanese Healthy Participants

Condition: Healthy
Interventions: Drug: CR8020; Drug: Placebo
Sponsor: Janssen Pharmaceutical K.K.
Withdrawn
to Assess the Safety of Ga68-Dolacga Injection in Healthy Volunteers

Condition: Safety Issues
Intervention: Drug: Ga68-Dolacga Injection
Sponsor: Institute of Nuclear Energy Research, Taiwan
Enrolling by invitation
Safety of Inhaled Hydrogen Gas Mixtures in Healthy Volunteers

Condition: Healthy
Intervention: Drug: Hydrogen
Sponsor: Boston Children’s Hospital
Not yet recruiting
A Study in Healthy Men and Women to Test Which Effects Donepezil and BI 425809 Have on Each Other

Condition: Healthy
Interventions: Drug: BI 425809; Drug: Donepezil
Sponsor: Boehringer Ingelheim
Completed
Effect of a Simulated Flight in Patients With Type 2 Diabetes and Healthy Volunteers

Condition: Type 2 Diabetes
Interventions: Other: Hypoxia; Other: Low Humidity
Sponsor: Hull and East Yorkshire Hospitals NHS Trust
Completed
A Phase I, Healthy Volunteer Positron Emission Tomography Study

Condition: Healthy
Interventions: Other: Positron Emission tomography; Drug: PET Scan with PF-03654746
Sponsors: Pfizer; Yale University
Completed
A Study to Investigate Safety and Tolerability, Pharmacokinetics and Pharmacodynamics of JNJ-55375515 in Healthy Male Participants

Condition: Healthy
Interventions: Drug: JNJ-55375515 Dose Level 1; Drug: JNJ-55375515 Dose Level 2; Drug: JNJ-55375515 Dose Level 3; Drug: JNJ-55375515 Dose Level 4; Drug: JNJ-55375515 Dose Level 5; Drug: JNJ-55375515 Dose Level 6; Drug: Placebo; Drug: JNJ-55375515
Sponsor: Janssen Research & Development, LLC
Completed
PaTH Clinical Data Research Network (CDRN) Study of Healthy Lifestyles and Health Care

Condition: Weight
Intervention:
Sponsors: University of Pittsburgh; Temple University; Johns Hopkins University; Penn State University; Geisinger Clinic
Active, not recruiting
Absorption, Metabolism and Excretion (AME) of Single Dose Radiolabeled BVD-523 in Volunteers

Condition: Healthy
Intervention: Drug: [14C]-BVD-523
Sponsor: BioMed Valley Discoveries, Inc
Completed
Safety, Tolerability, Pharmacokinetics, and Preliminary Pharmacodynamics of QBW251 in Healthy Subjects and Cystic Fibrosis Patients

Condition: Cystic Fibrosis
Interventions: Drug: Placebo; Drug: QBW251
Sponsor: Novartis Pharmaceuticals
Terminated
A SAD, MAD, and FE Study to Evaluate the Safety, Tolerability, and Pharmacokinetic Profile of FM101 in Healthy Volunteers

Condition: Healthy Subjects
Interventions: Drug: FM101 for SAD; Drug: Placebo for SAD; Drug: FM101 for MAD; Drug: Placebo for MAD
Sponsor: Future Medicine
Recruiting
Relative Bioavailability of NXP001 Compared to Emend® in Healthy Volunteers

Condition: Healthy
Intervention: Drug: Aprepitant 125 mg
Sponsor: Nuformix Technologies Limited
Active, not recruiting
Investigation of AAI101 Safety, Tolerability & PK in Healthy Volunteers

Condition: Healthy
Interventions: Drug: AAI101 i.v.; Drug: Saline 0.9% infusion; Drug: Piperacillin i.v.; Drug: Cefepime i.v.
Sponsor: Allecra
Completed
A First-In-Human Study of Orally Administered JNJ-64417184 to Evaluate the Safety, Tolerability, and Pharmacokinetics of Single and Multiple Ascending Doses, and the Antiviral Activity of Multiple Doses in a Respiratory Syncytial Virus (RSV) Challenge Study in Healthy Participants

Condition: Healthy
Interventions: Drug: JNJ-64417184; Drug: Placebo
Sponsor: Janssen BioPharma, Inc.
Recruiting
Brasília Study on Healthy Aging

Condition: Healthy
Intervention:
Sponsors: University of Campinas, Brazil; Instituto de Cardiologia Biocardios; University of Brasilia
Completed
Multiple Ascending Dose Study of CTP-692 in Healthy Volunteers

Condition: Healthy
Intervention: Drug: CTP-692
Sponsor: Concert Pharmaceuticals
Completed
Effect of Metformin and Probiotics on Gut Microbiome in Healthy Subjects

Condition: Healthy
Interventions: Drug: Metformin powder; Drug: Probiotics powder; Other: Placebo powder
Sponsor: The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Completed
Safety and Tolerability of PNT001 in Healthy Adults

Condition: Healthy
Interventions: Biological: PNT001; Drug: Placebo
Sponsor: Pinteon Therapeutics, Inc
Recruiting
Safety and Pharmacokinetic Study of OMT-28 in Healthy Subjects

Condition: Healthy Volunteers
Interventions: Drug: OMT-28; Other: Matching Placebo
Sponsor: Omeicos Therapeutics GmbH
Completed
A Study to Evaluate the Pharmacokinetics, Safety and Tolerability of HGP1602 in Healthy Subjects

Condition: Healthy
Interventions: Drug: HGP1812; Drug: HGP1602
Sponsor: Hanmi Pharmaceutical Company Limited
Completed
A Safety, Tolerability, and Pharmacokinetic Study of Tucatinib in Healthy Japanese and Caucasian Subjects

Condition: Healthy
Intervention: Drug: Tucatinib
Sponsor: Seattle Genetics, Inc.
Completed
Single Dose of Lu AF28996 to Healthy Young Men

Condition: Healthy
Interventions: Drug: Lu AF28996 solution; Drug: Lu AF28996 capsule
Sponsor: H. Lundbeck A/S
Completed
Pharmacodynamic and Safety of MBA-P01 in Healthy Male Volunteers

Condition: Healthy
Interventions: Drug: MBA-P01; Drug: BOTOX
Sponsor: Medy-Tox
Completed
Safety, Tolerability & Pharmacokinetics of LEVI-04 in Healthy Volunteers and Patients With Osteoarthritis Knee Pain

Conditions: Healthy Volunteers; Osteoarthritis
Interventions: Drug: LEVI-04; Drug: Placebo
Sponsors: Levicept; Hammersmith Medicines Research
Recruiting
A Study of Lasmiditan in Healthy Chinese Participants

Condition: Healthy
Interventions: Drug: Lasmiditan; Drug: Placebo
Sponsor: Eli Lilly and Company
Not yet recruiting
Pharmacokinetics and Safety of DWP14012 Tablet A and Tablet B in Healthy Volunteers

Condition: Healthy
Interventions: Drug: DWP14012 tablet A; Drug: DWP14012 tablet B
Sponsor: Daewoong Pharmaceutical Co. LTD.
Recruiting
Pharmacokinetics, Pharmacodynamics Profile and Tolerance of P03277 in Healthy Subjects and Patients With Brain Lesions

Conditions: Healthy Volunteers; Brain Lesion
Interventions: Drug: P03277; Drug: Placebo
Sponsor: Guerbet
Completed
Injectable DMAU for Male Contraception in Healthy Male Volunteers (CCN015)

Conditions: Healthy Men; Male Contraception
Interventions: Drug: Dimethandrolone Undecanoate; Drug: Placebo
Sponsors: Health Decisions; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD); Los Angeles Biomedical Research Institute; University of Washington
Recruiting
A Study in Healthy Subjects to Assess the Safety, Tolerability, PK and PD of HTL0030310

Condition: Healthy
Interventions: Drug: HTL0030310; Drug: Pasireotide; Drug: Placebo
Sponsor: Heptares Therapeutics Limited
Active, not recruiting
Safety and PK/PD of RTA 1701 in Healthy Adults

Condition: Healthy
Interventions: Drug: Placebo oral capsule; Drug: RTA 1701 capsules
Sponsor: Reata Pharmaceuticals, Inc.
Completed
A Study to Evaluate the Pharmacokinetics, Safety and Tolerability of HIP1801 in Healthy Male Subjects.

Condition: Healthy
Interventions: Drug: HIP1402; Drug: HIP1801
Sponsor: Hanmi Pharmaceutical Company Limited
Completed
Multiple Ascending Oral Dose 14-Day Trial of LHF-535 in Healthy Participants

Condition: Healthy
Intervention: Drug: LHF-535
Sponsors: Kineta Inc.; Wellcome Trust
Not yet recruiting
A Safety and Tolerability Study of JNJ-72537634 in Healthy Participants

Condition: Healthy
Interventions: Biological: JNJ-72537634; Biological: Placebo
Sponsor: Janssen Research & Development, LLC
Recruiting
A Study of Tirzepatide Administered by Two Different Devices in Healthy Participants

Condition: Healthy
Interventions: Drug: Tirzepatide; Device: Prefilled syringe (PFS); Device: Auto-injector (AI)
Sponsor: Eli Lilly and Company
Recruiting
Pharmacokinetics of HCP1305 and Co-administration of HCP0605, HGP0816 in Healthy Male Volunteers

Condition: Healthy
Interventions: Drug: HCP0605 + HGP0816; Drug: HCP1305
Sponsor: Hanmi Pharmaceutical Company Limited
Completed
A Study of JNJ-64530440 in Healthy Japanese Male Participants

Condition: Healthy
Interventions: Drug: JNJ-0440; Drug: Placebo
Sponsors: Janssen Pharmaceutical K.K.; Janssen Research & Development, LLC
Recruiting
Drug-Drug Interaction Study of "CG100650" in Healthy Volunteers

Condition: Healthy
Interventions: Drug: Polmacoxib and Tramadol combination; Drug: Polmacoxib; Drug: Tramadol hydrochloride
Sponsor: CrystalGenomics, Inc.
Recruiting
Acute Effects of a Heat-not-burn Tobacco Product on Pulmonary Function in Healthy Non Smokers.

Conditions: Heated Tobacco; Respiratory Function; Tobacco Toxicity
Intervention: Other: IQOS
Sponsor: Aristotle University Of Thessaloniki
Recruiting
A Study of PF-06651600 Effect on Rosuvastatin Pharmacokinetics in Healthy Participants

Condition: Healthy Volunteers
Interventions: Drug: PF-06651600; Drug: Rosuvastatin
Sponsor: Pfizer
Not yet recruiting
A Study to Test How Well Healthy Men Tolerate Different Doses of BI 706321

Condition: Healthy
Interventions: Drug: BI 706321; Drug: Placebo
Sponsor: Boehringer Ingelheim
Recruiting
Pharmacokinetics of Lidocaine in Healthy Adults

Condition: Healthy
Interventions: Drug: Lidocaine patch 5%; Drug: Lidocaine Hydrochloride; Drug: Lidoderm 5 % Topical Patch
Sponsors: Nicole K Brogden; Long Island University
Recruiting
A Study in Healthy Men and Women to Test Which Effects Memantine and BI 425809 Have on Each Other

Condition: Healthy
Interventions: Drug: BI 425809; Drug: Memantine
Sponsor: Boehringer Ingelheim
Active, not recruiting
A Study in Healthy Men to Find Out How BI 425809 is Taken up and Handled by the Body

Condition: Healthy
Intervention: Drug: BI 425809 mixed with [C-14] BI425809
Sponsor: Boehringer Ingelheim
Completed
Study of PF-04965842 Effect on Dabigatran Pharmacokinetics in Healthy Participants

Condition: Healthy
Interventions: Drug: PF-04965842; Drug: Dabigatran
Sponsor: Pfizer
Completed
Healthy Families Healthy Forces Study

Conditions: Overweight; Obesity
Interventions: Behavioral: Healthy Weight for Living (HWL); Behavioral: Current Best Practice (CBP)
Sponsors: Tufts University; United States Army Research Institute of Environmental Medicine
Active, not recruiting
A Study of JNJ-73763989 in Healthy Japanese Adult Participants

Condition: Healthy
Interventions: Drug: JNJ-73763989; Drug: Placebo
Sponsor: Janssen Sciences Ireland UC
Recruiting
Assessment of the Efficacy of Vitamin D-fortified Oil in Healthy Adults

Condition: Healthy
Interventions: Dietary Supplement: fortified oil; Dietary Supplement: Placebo
Sponsor: National Nutrition and Food Technology Institute
Completed
Study to Assess the Safety and Pharmacokinetic (PK) of CTP-692 in Healthy Volunteers

Condition: Healthy
Interventions: Drug: CTP-692; Drug: Placebo
Sponsor: Concert Pharmaceuticals
Completed
Study of PF-04965842 Effect on Rosuvastatin Pharmacokinetics in Healthy Participants

Condition: Healthy
Interventions: Drug: PF-04965842; Drug: Rosuvastatin
Sponsor: Pfizer
Completed
Tacrolimus Blood Levels After Topical Application of Tacrolimus on Healthy Skin

Condition: Healthy
Intervention: Drug: topical formulation of tacrolimus
Sponsor: LEO Pharma
Completed
A Study to Assess the Effect of AK3280 on Renal Function in Healthy Subjects

Condition: Healthy
Interventions: Drug: AK3280; Drug: Placebo
Sponsor: Ark Biosciences Inc.
Not yet recruiting
Phase 1 Study of TAK-831 in Healthy Adult Asian Subjects

Condition: Healthy Adult Asian Participants
Interventions: Drug: TAK-831; Drug: Placebo
Sponsor: Takeda
Completed
Respiratory Muscle Endurance Training in Healthy Elderly

Condition: Healthy
Intervention: Device: Respiratory muscle endurance training
Sponsor: Swiss Federal Institute of Technology
Completed
A Study to Evaluate the Pharmacokinetics, Safety and Tolerability of HCP1801 in Healthy Subjects

Condition: Healthy
Interventions: Drug: HCP1805; Drug: HCP1801
Sponsor: Hanmi Pharmaceutical Company Limited
Recruiting
A Study of JNJ-63733657 in Healthy Japanese Participants

Condition: Healthy
Interventions: Drug: JNJ-63733657; Drug: Placebo
Sponsor: Janssen Pharmaceutical K.K.
Completed
Recovery, Fatigability, and Proteomic Response to Aerobic Exercise Training in Healthy Individuals

Conditions: Adult; Fatigue
Intervention: Other: Aerobic Exercise Training
Sponsor: George Mason University
Completed
A Study in Healthy Men to Test Whether BI 1358894 Reduces Druginduced Panic Symptoms

Condition: Healthy
Interventions: Drug: BI 1358894; Drug: Placebo
Sponsor: Boehringer Ingelheim
Completed
The Effects of Prazosin on Dopamine in Healthy Humans: A PET Pilot Study

Condition: Healthy
Intervention: Drug: Prazosin Hydrochloride
Sponsors: Centre for Addiction and Mental Health; Ontario Lung Association; Pfizer
Completed
A Study to Evaluate the Effect of Itraconazole on JNJ-56136379 in Healthy Adult Participants

Condition: Healthy
Interventions: Drug: JNJ-56136379; Drug: Itraconazole
Sponsor: Janssen Sciences Ireland UC
Recruiting
Phase 1 Single Dose Study of ALXN1101 in Healthy Volunteers

Conditions: Molybdenum Cofactor Deficiency (MoCD); Rare Autosomal Recessive Disorder; Deficiency of Activity of Molybdenum-dependent Enzymes (Sulfite Oxidase [SOX], Xanthine Dehydrogenase, and Aldehyde Oxidase)
Interventions: Drug: ALXN1101; Drug: Placebo
Sponsor: Origin Biosciences
Completed
Singe Dose Study of PF- 06946860 in Healthy Adult Japanese Participants

Condition: Healthy
Interventions: Biological: PF-06946860; Other: Placebo
Sponsor: Pfizer
Recruiting
Pharmacodynamic and Safety of MEDITOXIN® in Healthy Male Volunteers

Condition: Healthy
Interventions: Drug: Meditoxin; Drug: Botox
Sponsor: Medy-Tox
Completed
Study to Compare Safety and Pharmacokinetics of "CG1801" and "CGL1802" in Healthy Volunteers

Condition: Healthy
Interventions: Drug: CG1801; Drug: CGL1802
Sponsor: CrystalGenomics, Inc.
Recruiting
Food-Effect on PK and PD of Single Oral Dose of Tegoprazan in Healthy Male Subjects

Condition: Healthy
Intervention: Drug: Tegoprazan 50mg
Sponsor: CJ HealthCare Corporation
Completed
Study to Evaluate Drug-Drug Interaction of DWP16001 in Combination With Metformin in Healthy Male Adults (Phase 1 Study)

Condition: Healthy
Interventions: Drug: DWP16001; Drug: Metformin IR; Drug: DWP16001+Metformin IR
Sponsor: Daewoong Pharmaceutical Co. LTD.
Recruiting
A Randomized, Controlled Study to Evaluate the Sensitizing Potential of FMX-101 in Healthy Volunteers Using a Repeat Insult Patch Test Design

Condition: Healthy
Intervention: Drug: FMX-101
Sponsor: Foamix Ltd.
Completed
Reliability of [18F]-FTC-146 Brain Uptake in Healthy Controls

Condition: Healthy Controls
Intervention: Drug: [18F]-FTC-146
Sponsor: Stanford University
Recruiting
A Study of LY3154885 in Healthy Participants

Condition: Healthy
Interventions: Drug: LY3154885 - Capsule; Drug: Placebo - Capsule; Drug: Itraconazole; Drug: LY3154885 - Tablet
Sponsor: Eli Lilly and Company
Recruiting
A Study of the Safety and Tolerability of CDX-6114 in Healthy Volunteers

Condition: Healthy
Interventions: Drug: CDX-6114; Drug: Placebo
Sponsor: Codexis Inc.
Recruiting
Safety Evaluation of β-arbutin in Healthy Human Subjects

Condition: Healthy Volunteers
Interventions: Dietary Supplement: Beta-arbutin; Other: Placebo
Sponsors: SP Nutraceuticals Inc.; Canadian Glycomics Network (GlycoNet)
Recruiting
HEC53856 Phase 1 Study - Single and Multiple Oral Dosing in Healthy Volunteers

Condition: Healthy
Interventions: Drug: HEC53856; Drug: placebo
Sponsor: Sunshine Lake Pharma Co., Ltd.
Recruiting
Mass Balance Recovery and Metabolite Profile of CORT125281 in Healthy Male Participants

Condition: Healthy
Intervention: Drug: 14C-CORT125281
Sponsor: Corcept Therapeutics
Completed
Activation Patterns of Respiratory Muscles to Loaded Inspiratory Muscle Tests in Healthy Adults Under Different Posture

Condition: Accessory Muscle
Intervention: Other: Loaded inspiratory muscle test
Sponsor: National Taiwan University Hospital
Completed
A Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics Study of TAK-828 Escalating Multiple-Doses in Healthy Participants

Condition: Healthy Volunteers
Interventions: Drug: TAK-828; Drug: Placebo
Sponsor: Takeda
Terminated
Low-dose IL-2 to the Kinetics of Regulatory T-cell in Healthy Volunteers

Condition: Healthy Volunteers
Interventions: Drug: ILT101; Drug: Placebo
Sponsors: Assistance Publique - Hôpitaux de Paris; Iltoo Pharma
Not yet recruiting
A Study in Healthy Adults to Evaluate the Safety and Immunogenicity of Different Doses of JNJ-63871860

Condition: Healthy
Interventions: Biological: ExPEC4V (4 : 4 : 4 : 4); Biological: ExPEC4V (4 : 4 : 4 : 8); Biological: ExPEC4V (8 : 8 : 8 : 8); Biological: ExPEC4V (8 : 8 : 8 : 16); Biological: ExPEC4V (16 : 16 : 16 : 16); Drug: Placebo
Sponsor: Janssen Research & Development, LLC
Active, not recruiting
A Phase 1 Study to Assess the Pharmacokinetics of AZD9977 Administered Alone and in Combination With Itraconazole in Healthy Volunteers

Condition: Heart Failure With Preserved Ejection Fraction (HFpEF)
Interventions: Drug: AZD9977; Drug: Itraconazole
Sponsor: AstraZeneca
Completed
Individualized Transcranial Direct Current Stimulation for Gait Function in Healthy Subjects

Conditions: Healthy Adults; Healthy Aging
Interventions: Device: Individualized transcranial direct current stimulation; Device: Conventional transcranial direct current stimulation
Sponsor: Samsung Medical Center
Not yet recruiting
Evaluate the PK of Multiple Oral Doses of Tegoprazan, Metronidazole, Tetracycline and Bismuth in Healthy Volunteers

Condition: Healthy
Interventions: Drug: Tegoprazan; Drug: Metronidazole; Drug: Tetracycline; Drug: Bismuth
Sponsor: CJ HealthCare Corporation
Completed
A Study to Investigate the Safety, Tolerability and Pharmacokinetics of MT-6345 in Healthy Subjects

Condition: Healthy
Interventions: Drug: MT-6345; Drug: MT-6345 Placebo
Sponsor: Mitsubishi Tanabe Pharma Development America, Inc.
Recruiting
Study With Lu AF35700 in Healthy Men and Women in Fasting and Fed State

Condition: Healthy
Interventions: Drug: Lu AF35700; Drug: Lu AF35700 iv
Sponsor: H. Lundbeck A/S
Completed
A Study of (14C) Radiolabeled JNJ-56136379 in Healthy Male Participants

Condition: Healthy
Intervention: Drug: 14C-JNJ-56136379
Sponsor: Janssen Research & Development, LLC
Completed
Evaluation of Postprandial Glycaemia in a Healthy Population After Intake of Milk and Oat Based Products

Condition: Healthy
Interventions: Other: Bread reference; Other: Product 1: Milk; Other: Product 2: Full fat milk + oat; Other: Product 3: Skim milk + oat, high fibre; Other: Product 4: Skim milk + oat, low fibre
Sponsor: Aventure AB
Completed
Study of Guselkumab and Ustekinumab Following a Single Intravenous or Subcutaneous Administration in Healthy Chinese Participants

Condition: Healthy
Interventions: Drug: Guselkumab (SC): Dose 1; Drug: Guselkumab (SC): Dose 2; Drug: Guselkumab (IV): Dose 1; Drug: Guselkumab (IV): Dose 2; Drug: Ustekinumab 6 mg/mL
Sponsor: Janssen Research & Development, LLC
Not yet recruiting
OPEN LABEL, 2-PERIOD STUDY, TO COMPARE BIO-AVAILABILITY OF 2 DIFFERENT FORMULATIONS OF PF-05221304 IN HEALTHY ADULTS

Condition: Healthy
Interventions: Drug: PF-05221304 Formulation A; Drug: PF-05221304 Formulation B
Sponsor: Pfizer
Completed
A Study to Investigate the Drug-drug Interactions Between ACT-541468 and Ethanol in Healthy Subjects

Condition: Healthy
Interventions: Drug: ACT-541468; Other: ACT-541468 placebo; Other: Ethanol 10%; Other: Ethanol placebo
Sponsor: Idorsia Pharmaceuticals Ltd.
Completed
A Clinical Study to Investigate the Food Effect on the Pharmacokinetics of ACT-541468 in Healthy Male Subjects

Condition: Healthy
Intervention: Drug: ACT-541468
Sponsor: Idorsia Pharmaceuticals Ltd.
Completed
A Study in Healthy Men and Women to Find Out How Well Different Doses of BI 1291583 Are Tolerated

Condition: Healthy
Interventions: Drug: BI 1291583; Drug: Placebo
Sponsor: Boehringer Ingelheim
Recruiting
Single Ascending Dose PK, Oral Bioavailability and Food Effect Study in Healthy Male Volunteers

Condition: Healthy
Interventions: Drug: Indoximod HCL (F2) tablets; Drug: Indoximod base formulation; Other: Placebo
Sponsor: NewLink Genetics Corporation
Completed
A Study to Assess Potential Interaction Between ASP8062 and Alcohol in Healthy Adult Subjects

Condition: Healthy Volunteers
Interventions: Drug: ASP8062; Drug: Alcohol; Drug: ASP8062 Placebo; Drug: Alcohol Placebo
Sponsor: Astellas Pharma Global Development, Inc.
Recruiting
A Study of IW-6463 in Healthy Volunteers

Condition: Healthy Volunteers
Interventions: Drug: IW-6463; Drug: Matching Placebo
Sponsor: Cyclerion Therapeutics
Recruiting
The Impact of Enteral Versus Oral Protein Feeding on Muscle Protein Synthesis in Healthy Young Males and Females

Condition: Healthy
Interventions: Other: Oral Placebo; Other: Oral Protein; Other: Enteral Protein
Sponsor: University of Exeter
Completed
Single Ascending Dose of GAP-134 as a 24-hour IV Infusion in Healthy Japanese Males

Condition: Arrhythmia
Intervention: Drug: GAP-134
Sponsor: Wyeth is now a wholly owned subsidiary of Pfizer
Completed
A Study of LY3526318 in Healthy Participants

Condition: Healthy
Interventions: Drug: LY3526318; Drug: Placebo
Sponsor: Eli Lilly and Company
Recruiting
Single-ascending Dose Phase 1 Clinical Trial to Evaluate the Safety and PK of DA-5207 TDS in Healthy Adults

Condition: Healthy
Interventions: Drug: DA-5207; Drug: Donepezil Hydrochloride
Sponsor: Dong-A ST Co., Ltd.
Recruiting
Clinical Trial to Explore the the Amyloid Beta Draining Effect of Thiethylperazine (TEP) in Subjects With Newly Diagnosed Early-to-mild Dementia Due to Alzheimer's Disease (AD) in Comparison to Healthy Volunteers

Condition: Alzheimer Disease
Intervention: Drug: TEP
Sponsor: Immungenetics AG
Active, not recruiting
Study of Lemborexant-Alcohol Interaction in Healthy Subjects

Condition: Healthy Subjects
Interventions: Drug: Lemborexant; Drug: Alcohol; Drug: Placebo
Sponsors: Eisai Inc.; Purdue Pharma LP
Completed
Single Ascending Dose Study of Lu AF76432 in Healthy Young Men

Condition: Healthy
Interventions: Drug: Placebo; Drug: Lu AF76432
Sponsor: H. Lundbeck A/S
Completed
A Drug Interaction Study of LY3154207 in Healthy Participants

Condition: Healthy
Interventions: Drug: LY3154207 Capsule; Drug: LY3154207 Tablet; Drug: Placebo; Drug: Fluconazole Tablet
Sponsor: Eli Lilly and Company
Recruiting
A Study to Evaluate the Pharmacokinetic and Pharmacodynamic Interactions Between HGP0904, HGP0608, and HCP1306 in Healthy Male Subjects.

Condition: Healthy
Interventions: Drug: HCP1306; Drug: HGP0904; Drug: HGP0608
Sponsor: Hanmi Pharmaceutical Company Limited
Completed
A Food-Effect Study of SHC014748M in Healthy Subjects

Condition: Healthy Volunteer
Intervention: Drug: SHC014748M Capsules
Sponsor: Nanjing Sanhome Pharmaceutical, Co., Ltd.
Not yet recruiting
Effect of Tegoprazan on Pharmacodynamics of Clopidogrel in Healthy Male Participants

Condition: Healthy
Interventions: Drug: Clopidogrel 75 mg; Drug: Tegoprazan 50 mg; Drug: Esomeprazole 20 mg
Sponsor: CJ HealthCare Corporation
Recruiting
A Study in Healthy Subjects to Investigate Whether Administration of Lucerastat Can Affect Normal Heart Function

Condition: Healthy
Interventions: Drug: Lucerastat (Treatment A); Other: Placebo; Drug: Moxifloxacin; Drug: Lucerastat (Treatment B); Drug: Lucerastat (Treatment C)
Sponsor: Idorsia Pharmaceuticals Ltd.
Active, not recruiting
Metabolism and Disposition of [14C] Herombopag in Chinese Healthy Human Subjects

Condition: Healthy
Intervention: Drug: Hetrombopag Olamine
Sponsor: Jiangsu HengRui Medicine Co., Ltd.
Recruiting
A DRUG-DRUG INTERACTION STUDY BETWEEN PF-06650833 AND PF-06651600 FOLLOWING MULTIPLE DOSES IN HEALTHY PARTICIPANTS

Condition: Healthy
Interventions: Drug: PF-06650833 alone; Drug: PF-06651600 alone; Drug: PF-06650833 together with PF-06651600
Sponsor: Pfizer
Completed
Radiolabeled Study of AG-221 in Healthy Male Subjects.

Condition: Healthy Volunteers
Interventions: Drug: AG-221; Radiation: 14C AG-221
Sponsor: Celgene
Completed
A Study of JNJ-64140284 Solid Dose Formulations in Healthy Male Participants

Condition: Healthy
Intervention: Drug: JNJ-64140284
Sponsor: Janssen Research & Development, LLC
Not yet recruiting
A Study of Benzathine Benzylpenicillin Intramuscular Injection in Japanese Healthy Subjects

Condition: Healthy
Intervention: Drug: penicillin G benzathine
Sponsor: Pfizer
Completed
Effect of Food on the Pharmacokinetics of Decitabine/Tetrahydrouridine Combination Capsules in Healthy Adult Subjects

Condition: Healthy
Intervention: Drug: Decitabine
Sponsor: EpiDestiny, Inc.
Not yet recruiting
The Establishment of Large-sample Database of "Multiple-MRI/Gene/Cognition"

Condition: Healthy
Intervention: Device: MRI
Sponsor: Hangzhou Normal University
Recruiting
First-in-human Study in Healthy Subjects

Condition: Healthy
Interventions: Drug: CORT118335, 25 mg; Drug: Prednisone Oral Tablet; Drug: Glucose; Drug: Placebo oral suspension; Drug: CORT118335, 75mg; Drug: CORT118335, 225mg; Drug: CORT118335, 675mg; Drug: CORT118335, 600mg; Drug: CORT118335, 630mg; Drug: CORT118335, 375mg; Drug: CORT118335, 100mg; Drug: CORT118335, 300mg; Drug: CORT118335, 900mg; Drug: CORT118335, 150mg; Drug: CORT118335, 1500mg; Drug: Placebo oral capsule; Drug: CORT118335, dose to be determined
Sponsor: Corcept Therapeutics
Completed
Effect of Red Furu Consumption on Serum Vitamin B12 and Homocysteine Concentration In Healthy Young Volunteers

Condition: Healthy
Interventions: Other: Red Furu; Other: Tofu
Sponsor: Zhejiang University
Completed
A Study of LY900020 in Healthy Chinese Participants

Condition: Healthy
Interventions: Drug: LY900020; Drug: Metformin XR; Drug: Atorvastatin; Drug: Valsartan
Sponsor: Eli Lilly and Company
Not yet recruiting
A Study in Healthy Men to Test the Effects of Different Doses of BI 1467335 on MAO-B Activity in the Brain.

Condition: Healthy
Intervention: Drug: BI 1467335
Sponsor: Boehringer Ingelheim
Recruiting
Evaluate the Pharmacokinetics of CC-220 in Subjects With Mild, Moderate, or Severe Hepatic Impairment Compared With Healthy Subjects

Conditions: Hepatic Impairment; Healthy Volunteers
Intervention: Drug: CC-220
Sponsor: Celgene
Not yet recruiting
A Study to Assess the Effect of Ritonavir on the Single-Dose Pharmacokinetics of JNJ-61393215 in Healthy Participants

Condition: Healthy
Interventions: Drug: JNJ-61393215; Drug: Ritonavir
Sponsor: Janssen Research & Development, LLC
Completed
Compare the Pharmacokinetic of K-877 Controlled Release (CR) and Immediate Release (IR) Tablets in Healthy Adults.

Condition: Healthy
Interventions: Drug: K-877 CR Tablet A; Drug: K-877 CR Tablet B; Drug: K-877 CR Tablet E; Drug: K-877 IR Tablet
Sponsor: Kowa Research Institute, Inc.
Completed
Single Ascending Dose Study of PBI-4547 in Healthy Subjects

Condition: Healthy Subjects
Interventions: Drug: PBI-4547; Other: Placebo
Sponsors: ProMetic Pharma SMT Limited; Syneos Health
Recruiting
Investigating Memory in Healthy Subjects Using Transcranial Direct Current Stimulation

Condition: Healthy Adults
Intervention: Device: tDCS
Sponsor: The University of Texas at Dallas
Active, not recruiting
Noradrenaline, Acetylcholine and Dynamic Learning in Healthy Humans

Condition: Healthy
Interventions: Drug: Reboxetine; Drug: Rivastigmine; Drug: Placebo oral tablet
Sponsor: University of Oxford
Not yet recruiting
A Study to Assess the Relative Oral Bioavailability and Food Effect of Single-dose of JNJ-64417184 in Healthy Participants

Condition: Healthy
Interventions: Drug: JNJ-64417184 600 (Oral Tablet Formulation); Drug: JNJ-64417184 (Oral Suspension Formulation)
Sponsor: Janssen Research & Development, LLC
Recruiting
Effect of Cervical Spinal Stabilization Exercise Programs by Magnetic Resonance Imaging in Healthy Individuals

Condition: Healthy
Interventions: Other: Exercises focused on flexor muscles; Other: Exercises focused on extensor muscles
Sponsor: Hacettepe University
Completed
Drug Interaction Study Evaluating the Effect of Rifampin on PK and Safety of PF 04965842.

Condition: Healthy
Interventions: Drug: PF-04965842; Other: rifampin
Sponsor: Pfizer
Completed
Randomized, Single-dose, Crossover Study of 4 Decitabine and Tetrahydrouridine (EPI01) Formulations in Healthy Subjects

Condition: Healthy
Intervention: Drug: Decitabine
Sponsor: EpiDestiny, Inc.
Completed
A Study of Single Ascending Doses of STAR-101 in Healthy Participants

Condition: Healthy Volunteers
Interventions: Drug: Star-101; Drug: Placebo
Sponsor: Acanthas Pharma Inc
Not yet recruiting
Study to Evaluate Pharmacokinetics, Safety, and Tolerability Ildong COL-144 Tablet in Korean Healthy Volunteers

Condition: Healthy
Interventions: Drug: COL-144 50mg; Drug: COL-144 100mg; Drug: COL-144 200mg; Drug: COL-144 400mg; Drug: Placebo
Sponsor: IlDong Pharmaceutical Co Ltd
Not yet recruiting
A Study to Assess Interaction Between JNJ-64417184 and JNJ-53718678 After Single and Multiple Dosing in Healthy Participants

Condition: Healthy
Interventions: Drug: JNJ-53718678; Drug: JNJ-64417184
Sponsor: Janssen Research & Development, LLC
Not yet recruiting
To Compare the Pharmacokinetics and Safety of CT-P17 and Humira (US Licensed Humira and EU-approved Humira) in Healthy Subjects

Condition: Healthy
Interventions: Biological: CT-P17; Biological: US-licensed Humira; Biological: EU approved Humira
Sponsor: Celltrion
Active, not recruiting
A Study About How Different Doses of BI 1358894 Are Taken up in the Body and How Well They Are Tolerated in Healthy Japanese Men

Condition: Healthy
Interventions: Drug: BI 1358894; Drug: Placebo
Sponsor: Boehringer Ingelheim
Completed
A Clinical Study to Examine the Drug-drug Interactions Between ACT-541468 and Citalopram in Healthy Male and Female Subjects

Condition: Healthy
Interventions: Drug: ACT541468; Drug: ACT541468 placebo; Drug: Citalopram
Sponsor: Idorsia Pharmaceuticals Ltd.
Completed
Study to Assess the Safety, Tolerability, and Pharmacokinetics of BIIB104 in Healthy Japanese and Non-Japanese Participants

Condition: Healthy Volunteers
Interventions: Drug: BIIB104; Drug: Placebo
Sponsor: Biogen
Not yet recruiting
A Study of Ponesimod in Healthy Adult Participants Receiving Propranolol at Steady State

Condition: Healthy
Interventions: Drug: Ponesimod dose range (2 - 20 mg); Drug: Placebo Propranolol; Drug: Propranolol 80 mg
Sponsor: Janssen Pharmaceutica N.V., Belgium
Recruiting
Study to Evaluate the Safety, Tolerability, PK, and PD of PB2452 in Healthy Volunteers

Condition: Healthy
Interventions: Drug: PB2452 Infusion; Drug: Placebo - Sodium Chloride; Drug: Ticagrelor Oral Tablet - Pre-Treatment; Drug: Ticagrelor Oral Tablet - Pre-Treatment and Post-Treatment
Sponsor: PhaseBio Pharmaceuticals Inc.
Completed
A Study to Evaluate the Safety of K-755 in Healthy Volunteers

Condition: Healthy
Interventions: Drug: K-755 Part A (SAD); Drug: Placebo Part A (SAD); Drug: K-755 Part B (MAD); Drug: Placebo Part B (MAD); Drug: K-755 Part C (FE); Drug: K-755 Part D (FE); Drug: K-755 Part E (MAD); Drug: Placebo Part E (MAD)
Sponsor: Kowa Company, Ltd.
Recruiting
A Study to Evaluate the Effect of JNJ-53718678 on the Cardiac Repolarization Interval in Healthy Adult Participants

Condition: Healthy
Interventions: Drug: JNJ-53718678, 2000 mg; Drug: JNJ-53718678, 3000 mg; Drug: JNJ-53718678, 4500 mg or Dose to be decided; Drug: JNJ-53718678 500 mg; Drug: JNJ-53718678 Placebo; Drug: Moxifloxacin 400 mg; Drug: Moxifloxacin Placebo
Sponsor: Janssen Research & Development, LLC
Recruiting
To Evaluate the Safety, Tolerability and Pharmacokinetics of K0706 in Plasma and Cerebrospinal Fluid in Healthy Volunteers

Condition: Healthy
Intervention: Drug: K0706
Sponsor: Sun Pharma Advanced Research Company Limited
Recruiting
A Study of Apalutamide Administered Orally as Whole Tablets and as a Mixture in Applesauce in Healthy Participants

Condition: Healthy
Intervention: Drug: Apalutamide
Sponsor: Janssen Research & Development, LLC
Completed
Single Ascending Dose (SAD) and Multiple Ascending Dose (MAD) Study of M5049 in Healthy Participants

Condition: Healthy
Interventions: Drug: M5049; Drug: Placebo
Sponsor: Merck KGaA, Darmstadt, Germany
Recruiting
The Study of a Selective Serotonin Partial Agonist and Reuptake Inhibitors, HEC113995PA•H2O,in Healthy Subjects

Condition: Healthy
Interventions: Drug: HEC113995PA•H2O tablet; Drug: Placebo tablet
Sponsor: Sunshine Lake Pharma Co., Ltd.
Not yet recruiting
Investigating Memory Retrieval Improvement in Healthy Subjects

Condition: Healthy Adults
Interventions: Device: active anodal tDCS; Device: sham tDCS; Device: active cathodal tDCS
Sponsor: The University of Texas at Dallas
Active, not recruiting
A Study to Investigate the Effects of Gastric Acid Suppression by Rabeprazole and BMS-986165 on How Fast and Complete The Drug is Absorbed Into the Body of Healthy Participants

Condition: Healthy
Interventions: Drug: BMS-986165; Drug: Rabeprazole
Sponsor: Bristol-Myers Squibb
Completed
Bioequivalence Study of CJ-30060 in Healthy Volunteers

Condition: Healthy Subjects
Interventions: Drug: Exforge® tab 5/160mg, Crestor® tab 10mg; Drug: CJ-30060 5/160/10mg
Sponsor: CJ HealthCare Corporation
Recruiting
Bioavailability Study of SPARC001(Study 1) in Healthy Adult Volunteers

Condition: Healthy
Interventions: Drug: SPARC001 type I; Drug: SPARC001 type II; Drug: Reference001 type I; Drug: Reference001 type II
Sponsor: Sun Pharma Advanced Research Company Limited
Completed
Bioavailability Study of SPARC001 (Study 2) in Healthy Adult Volunteers

Condition: Healthy
Interventions: Drug: SPARC001 type I; Drug: SPARC001 type II; Drug: Reference001 type I; Drug: Reference001 type II
Sponsor: Sun Pharma Advanced Research Company Limited
Completed
Pharmacokinetic Study of SH-1028 Tablets in Healthy Subjects Under Fasting and Fed Conditions

Condition: Healthy Volunteer
Intervention: Drug: SH-1028 Tablets
Sponsor: Nanjing Sanhome Pharmaceutical, Co., Ltd.
Not yet recruiting
Swallowing Pressure Profiles in Healthy Adults

Condition: Healthy
Interventions: Procedure: Videofluoroscopic swallow study; Procedure: pharyngeal High Resolution Manometry
Sponsor: University of Florida
Completed
Absolute Bioavailability and Metabolism Study of CORT118335 in Healthy Male Participants

Condition: Healthy
Interventions: Drug: CORT118335 Oral; Drug: 14C-CORT118335 intravenous; Drug: 14C-CORT118335 oral
Sponsor: Corcept Therapeutics
Completed
Pharmacokinetic, Safety, Tolerability, Immunogenicity, and Pharmacodynamic Study of SB12 in Healthy Subjects

Condition: Healthy
Intervention: Drug: Eculizumab
Sponsor: Samsung Bioepis Co., Ltd.
Completed
A Single and Multiple Dose Study of PF-05221304 in Healthy Japanese Adults

Condition: Healthy
Interventions: Drug: PF-05221304; Drug: Placebo
Sponsor: Pfizer
Completed
A Study to Investigate the Different Modes of (S) Ketamine Administration in Healthy Participants

Condition: Healthy
Interventions: Drug: (S)-ketamine Oral Thin Film; Drug: (S)-ketamine IV Infusion; Drug: Placebo
Sponsor: Janssen Research & Development, LLC
Completed
Safety, Tolerability, Pharmacokinetic Characteristics of hzVSF-v13 in Healthy Male Volunteers

Condition: Healthy
Interventions: Drug: hzVSF-v13; Drug: Placebo
Sponsor: ImmuneMed, Inc.
Enrolling by invitation
Single and Multiple Ascending Dose, First-in- Human Study in Healthy Subjects

Condition: Healthy
Interventions: Drug: TD-5202; Drug: Placebo
Sponsor: Theravance Biopharma
Not yet recruiting
A Trial of Behavioral Economic Interventions Among Food Pantry Clients

Condition: Food Preferences
Intervention: Behavioral: Behavioral economic intervention of online purchasing at a food pantry
Sponsors: University of Pennsylvania; Massachusetts General Hospital; University of Connecticut; National Cancer Institute (NCI)
Recruiting
Safety, Tolerability, and Pharmacokinetics of REGN5069 in Healthy Volunteers

Condition: Healthy Volunteer
Interventions: Drug: REGN5069; Drug: Placebo
Sponsor: Regeneron Pharmaceuticals
Active, not recruiting
First-In-Human Study to Evaluate Safety And Pharmacokinetics of Single Escalating Doses of BCD-147 (Bispecific Anti-HER2/HER2 Antibody) in Healthy Subjects

Condition: Healthy
Intervention: Biological: BCD-147
Sponsor: Biocad
Recruiting
Oral Bioavailability,and Food Effect Study and Single Ascending Dose PK Study in Healthy Male Volunteers

Condition: Healthy
Interventions: Drug: Indoximod base formulation; Drug: Indoximod HCL (salt) formulation; Other: Placebo
Sponsor: NewLink Genetics Corporation
Completed
Single-dose Study of [14C]PF-05221304 Metabolism and Excretion in Healthy Adult Male Subjects

Condition: Healthy
Intervention: Drug: [14C]PF-05221304
Sponsor: Pfizer
Completed
A Study of Safety and Tolerability of NOX66 in Healthy Volunteers

Condition: Healthy Volunteers
Interventions: Drug: Oral idronoxil suspension; Drug: NOX66 (A); Drug: NOX66 (B)
Sponsor: Noxopharm Limited
Withdrawn
The Study of a Selective 5-ht6 Receptor Antagonist, HEC30654AcOH,in Healthy Subjects

Condition: Healthy
Interventions: Drug: HEC30654AcOH capsule; Drug: Placebo capsule
Sponsor: Sunshine Lake Pharma Co., Ltd.
Enrolling by invitation
Assessing the Safety and Tolerability of CSL730 in Healthy Caucasian and Japanese Adults

Condition: Healthy
Interventions: Biological: CSL730; Other: Placebo
Sponsor: CSL Behring
Active, not recruiting
A Family Literacy Program for Latino Families

Condition: Literacy
Intervention: Behavioral: Ready and Healthy for Kindergarten Family Literacy program
Sponsor: Rutgers, The State University of New Jersey
Enrolling by invitation
A Study to Evaluate the Effect and Tolerance of Musclin™ (Thymol) in Healthy Subjects

Condition: Healthy Volunteers
Intervention: Dietary Supplement: Thymol
Sponsor: Innovus Pharmaceuticals, Inc.
Recruiting
Clinical Trial of GX-I7 in Healthy Volunteers

Condition: Healthy
Interventions: Drug: GX-I7; Drug: Placebo
Sponsor: Genexine, Inc.
Completed
A Study of Galcanezumab (LY2951742) in Healthy Chinese Participants

Condition: Healthy
Interventions: Drug: Galcanezumab; Drug: Placebo
Sponsor: Eli Lilly and Company
Not yet recruiting
A Study in Healthy Men Tests How Different Doses of BI 764198 Are Taken up in the Body and How Well They Are Tolerated.

Condition: Healthy
Interventions: Drug: BI 764198; Drug: Placebo
Sponsor: Boehringer Ingelheim
Completed
Levoketoconazole Food Effect Study in Healthy Subjects

Condition: Healthy Subjects
Intervention: Drug: levoketoconazole
Sponsor: Cortendo AB
Completed
A Study of LY3361237 in Healthy Participants

Condition: Healthy
Interventions: Drug: LY3361237 - SC; Drug: LY3361237 - IV; Drug: Placebo - SC; Drug: Placebo - IV
Sponsor: Eli Lilly and Company
Completed
The Pharmacokinetics, and Safety of Brexpiprazole Tablets in Chinese Healthy Subjects

Condition: Healthy
Intervention: Drug: Brexpiprazole
Sponsor: Otsuka Beijing Research Institute
Active, not recruiting
Bioavailability Study of K0706 in Healthy Subjects

Condition: Healthy
Intervention: Drug: K0706
Sponsor: Sun Pharma Advanced Research Company Limited
Completed
A Study to Assess ASP2713 in Healthy Subjects

Condition: Healthy Volunteers
Interventions: Drug: ASP2713; Drug: placebo
Sponsor: Astellas Pharma Global Development, Inc.
Withdrawn
A Study in Healthy Men to Test How BI 730357 is Processed by the Body

Condition: Healthy
Intervention: Drug: BI 730357 mixed with [C-14]BI 730357 BS
Sponsor: Boehringer Ingelheim
Completed
Investigating Accelerated Learning in Healthy Subjects: Trigeminal Nerve Stimulation

Condition: Healthy Adults
Intervention: Device: Transcranial Direct Current Stimulation- Neuroconn DC Stimulator PLUS
Sponsor: The University of Texas at Dallas
Active, not recruiting
A Study to Investigate the Whole Body Distribution and Radiation Dosimetry of the Positron Emission Tomography Ligand Fluoride-18 (18F)-JNJ-64326067 in Healthy Participants

Condition: Healthy
Intervention: Drug: 18F-JNJ-64326067
Sponsor: Janssen Research & Development, LLC
Completed
A Study of LY2963016 in Healthy Chinese Participants

Condition: Healthy
Interventions: Drug: LY2963016; Drug: Insulin Glargine (Lantus)
Sponsor: Eli Lilly and Company
Recruiting
A Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single Ascending Doses of ACT-1004-1239 in Healthy Male Subjects

Condition: Healthy
Interventions: Drug: ACT-1004-1239; Other: Placebo; Drug: ACT-1004-1239 (Food-effect subpart); Other: Placebo (Food-effect subpart)
Sponsor: Idorsia Pharmaceuticals Ltd.
Recruiting
Levomilnacipran in Healthy Males

Condition: None (i.e. Healthy Volunteers)
Interventions: Drug: Levomilnacipran; Drug: Duloxetine; Drug: Placebos
Sponsors: University of Ottawa; Allergan
Recruiting
MSB11022 in Healthy Subjects

Condition: Healthy Subjects
Interventions: Drug: MSB11022; Drug: US-licensed Humira; Drug: EU-approved Humira
Sponsor: Fresenius Kabi SwissBioSim GmbH
Completed
Phase 1, Safety and Bronchopulmonary PK Study in Healthy Volunteers

Condition: Healthy Subjects
Interventions: Drug: TP-6076; Procedure: Bronchoalveolar lavage
Sponsors: Tetraphase Pharmaceuticals, Inc.; PRA Health Sciences
Active, not recruiting
A Study of LY3374849 in Healthy Participants

Condition: Healthy
Interventions: Drug: LY3374849 - SC; Drug: Insulin Degludec - SC; Drug: LY3374849 - IV; Drug: Insulin Degludec - IV
Sponsor: Eli Lilly and Company
Active, not recruiting
Investigating the Acute Effects of Blueberry (Poly)Phenols on Vascular Function and Cognition in Healthy Individuals.

Condition: Healthy
Interventions: Dietary Supplement: Wild Blueberry Powder; Dietary Supplement: Placebo
Sponsors: King's College London; University of Reading
Recruiting
A Study of the Effects of LY3372689 on the Brain in Healthy Participants

Condition: Healthy
Interventions: Drug: LY3372689; Diagnostic Test: [18F]LSN3316612
Sponsor: Eli Lilly and Company
Recruiting
A Single and Multiple Dose Study to Investigate Safety, Tolerability and Pharmacokinetics of JNJ-42165279 in Healthy Japanese Male Participants

Condition: Healthy
Interventions: Drug: JNJ-42165279; Drug: Placebo
Sponsor: Janssen Research & Development, LLC
Completed
Evaluation of Skin Irritation Potential With PF-06700841 Cream Formulation Using Negative Control in Adult Japanese Healthy Participants

Condition: Healthy
Interventions: Drug: PF-06700841 cream; Drug: White petrolatum
Sponsor: Pfizer
Completed
Dark Chocolate and Intestinal Motility

Condition: Gastrointestinal Motility
Intervention: Dietary Supplement: Healthy
Sponsor: University of Bari
Not yet recruiting
Acute Effect of a Standardized Botanical Blend Rich in Polyphenols on Cognitive Functions in Healthy Students

Condition: Healthy
Interventions: Dietary Supplement: SBRP; Dietary Supplement: PLACEBO
Sponsors: Activ'inside; CIC SANPSY (USR CNRS 3413), Hôpital Pellegrin, Bordeaux, FRANCE; Hospital St André, Bordeaux, FRANCE
Completed
A Study of LY3090106 in Japanese and Caucasian Healthy Participants

Condition: Healthy
Interventions: Drug: LY3090106; Drug: Placebo
Sponsor: Eli Lilly and Company
Completed
Constitution of a Biological Cohort Following Bone Marrow Sampling From MDS or AML Patients and Age-matched Healthy Donors

Conditions: Myelodysplastic Syndromes; Acute Myeloid Leukemia; Cardio-vascular Surgery
Intervention: Other: Bone marrow analyses
Sponsors: Institut de Cancérologie de la Loire; Centre Hospitalier Universitaire de Saint Etienne
Recruiting
First-in-Human Trial of Anti-ADAMTS-5 Nanobody in Healthy Volunteers

Condition: Healthy
Interventions: Drug: M6495; Drug: Placebo
Sponsor: Merck KGaA, Darmstadt, Germany
Completed
A Study to Evaluate the Effects of Single-dose Seltorexant on Electrocardiogram Intervals in Healthy Adult Participants

Condition: Healthy
Interventions: Drug: Seltorexant; Other: Placebo Matched to Seltorexant; Other: Placebo Matched to Moxifloxacin; Drug: Moxifloxacin Dose 1
Sponsor: Janssen Research & Development, LLC
Completed
Trial of IW-1973 (A Stimulator of Soluble Guanylate Cyclase (sGC)) in Healthy Volunteers

Condition: Healthy
Interventions: Drug: IW-1973; Drug: Matching Placebo Tablet
Sponsor: Cyclerion Therapeutics
Completed
Study To Assess Local Tolerability of Crisaborole 2% Ointment and Vehicle Ointment In Healthy Participants Using Subject-reported Assessments and Objective Measurements

Condition: Healthy
Interventions: Drug: Within-Subject Active vs Placebo Topical Applications; Drug: Within-Subject Active vs. Placebo Topical Applications
Sponsor: Pfizer
Completed
A Single Ascending Dose Study in Healthy Participants and Multiple Dose Study of JNJ-55920839 in Participants With Mild to Moderate Systemic Lupus Erythematosus

Conditions: Systemic Lupus Erythematosus; Healthy
Interventions: Drug: JNJ-55920839; Drug: Placebo
Sponsor: Janssen Research & Development, LLC
Completed
Safety and Effectiveness of BPL HRIG With Active Rabies Vaccine in Healthy Subjects

Condition: Healthy
Interventions: Drug: HRIG; Drug: HyperRAB; Biological: RabAvert
Sponsor: Bio Products Laboratory
Active, not recruiting
A Study to Assess the Safety, Tolerability and PK of NPT520-34 in Healthy Subjects

Condition: Healthy Volunteers
Interventions: Drug: NPT520-34 (125 mg); Drug: Placebos (125 mg)
Sponsors: Neuropore Therapies Inc.; Celerion
Recruiting
Study Evaluating Pharmacokinetics and Mass Balance of [14C]-CTP-543 in Healthy Adult Male Volunteers

Condition: Healthy Volunteers
Intervention: Drug: [14C]-CTP-543
Sponsors: Concert Pharmaceuticals; Celerion
Active, not recruiting
A Study Designed to Evaluate the Safety and Pharmacokinetics of Intravenously Administered Superoxide Dismutase Mimetic GC4711 in Healthy Volunteers

Condition: Healthy
Interventions: Drug: GC4711 30mg; Drug: GC4711 60mg; Drug: GC4711 90mg; Drug: GC4711 120mg; Drug: Placebo; Drug: GC4711 75mg; Drug: GC4711 105mg
Sponsor: Galera Therapeutics, Inc.
Recruiting
A Study of ACE-2494 in Healthy Subjects

Condition: Healthy Volunteers
Intervention: Drug: ACE-2494 or placebo
Sponsor: Acceleron Pharma, Inc.
Completed
A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of JNJ-64232025 in Healthy Participants

Condition: Healthy
Interventions: Drug: JNJ-64232025 IV; Drug: JNJ-64232025 SC; Drug: Placebo
Sponsor: Janssen Research & Development, LLC
Completed
A Phase I Study of SB26 in Healthy Volunteers

Condition: Healthy Volunteers
Interventions: Drug: SB26; Drug: Placebo
Sponsor: Samsung Bioepis Co., Ltd.
Active, not recruiting
A Study of Seltorexant (JNJ-42847922) After Single-Dose Administration in Healthy Participants

Condition: Healthy
Interventions: Drug: Seltorexant High Dose; Drug: Seltorexant Low Dose
Sponsors: Janssen Research & Development, LLC; Minerva Neurosciences
Recruiting
A Study to Evaluate the Safety, Reactogenicity and Immunogenicity of Ad26.ZIKV.001 in Healthy Adult Volunteers

Condition: Healthy
Interventions: Biological: Ad26.ZIKV.001 5*10^10 vp; Biological: Ad26.ZIKV.001 1*10^11 vp; Biological: Placebo
Sponsor: Janssen Vaccines & Prevention B.V.
Active, not recruiting
A Study to Evaluate the Antibody Response of Influenza Vaccination Following Concomitant Exposure to Bimekizumab in Healthy Subjects

Condition: Healthy Volunteers
Intervention: Drug: Bimekizumab
Sponsor: UCB Biopharma S.P.R.L.
Active, not recruiting
Safety and Pharmacokinetics Study of CPL500036 Compound in Healthy Volunteers

Condition: Healthy Volunteers
Interventions: Drug: CPL500036 compound; Drug: Placebo
Sponsors: Celon Pharma SA; National Center for Research and Development, Poland
Recruiting
Effect of Food and Calcium on Pharmacokinetics of a Single Dose of S-888711 in Healthy Adult Volunteers

Condition: Healthy Volunteer
Interventions: Drug: S-888711; Dietary Supplement: Calcium Antacid
Sponsor: Shionogi
Completed
A Comparison of the Safety and Immunogenicity of Various Schedules of Dengue Vaccine in Healthy Adult Volunteers

Condition: Healthy
Interventions: Biological: Takeda's Tetravalent Dengue Vaccine Candidate (TDV); Biological: TDV New Formulation; Drug: Placebo; Drug: New Formulation Placebo
Sponsor: Takeda
Completed
A Study to Assess the Safety, Tolerability and Pharmacokinetics of Guselkumab Following a Single Intravenous Administration in Healthy Japanese Participants

Condition: Healthy
Interventions: Drug: Guselkumab Dose 1; Drug: Guselkumab Dose 2; Drug: Guselkumab Dose 3; Drug: Placebo
Sponsor: Janssen Pharmaceutical K.K.
Completed
Phase I Study of D-0120 to Evaluate Safety and PK/PD Study in Healthy Volunteers

Condition: Healthy Volunteers
Interventions: Drug: D-0120; Drug: Placebo oral tablet
Sponsor: InventisBio Inc.
Recruiting
This Study in Healthy Men Tests How Different Doses of BI 1265162 Are Taken up in the Body and How Well They Are Tolerated.

Condition: Healthy
Interventions: Drug: BI 1265162; Drug: Placebo
Sponsor: Boehringer Ingelheim
Completed
A Study to Test How Well Healthy Men Tolerate Different Doses of BI 1356225

Condition: Healthy
Interventions: Drug: BI 1356225; Drug: Placebo
Sponsor: Boehringer Ingelheim
Recruiting
A Single and Multiple Ascending Dose Study of BMS-986318 in Healthy Participants

Condition: Healthy Participants
Interventions: Drug: BMS-986318; Other: Placebo
Sponsor: Bristol-Myers Squibb
Recruiting
Study to Evaluate the Effect of Multiple Doses of Itraconazole and Rifampin on the Single-Dose Pharmacokinetics of Mitapivat Sulfate (AG-348) in Healthy Adult Participants

Condition: Healthy Volunteers
Interventions: Drug: itraconazole; Drug: rifampin; Drug: mitapivat sulfate
Sponsor: Agios Pharmaceuticals, Inc.
Completed
A Study to Investigate the Safety, Tolerability and Pharmacokinetics of JNJ-64991524 in Healthy Participants

Condition: Healthy
Interventions: Drug: JNJ-64991524 Dose Level 1; Drug: JNJ-64991524 Dose Level 2; Drug: JNJ-64991524 Dose Level 3; Drug: JNJ-64991524 Dose Level 4; Drug: JNJ-64991524 Dose Level 5; Drug: JNJ-64991524 Dose Level 6; Drug: Placebo; Drug: JNJ-64991524 Dose Level 7; Drug: JNJ-64991524 Dose Level 8; Drug: JNJ-64991524 Dose Level 9
Sponsor: Janssen Research & Development, LLC
Completed
Phase 1, Healthy Subject, Safety, Tolerability and Pharmacokinetic Study of mGlu5 NAM HTL0014242

Condition: Healthy
Interventions: Drug: HTL0014242; Drug: Placebo oral capsule
Sponsors: Heptares Therapeutics Limited; Covance
Recruiting
Study to Investigate Safety, Tolerability, Pharmacokinetics, and Drug-drug Interaction of Multiple Oral Doses of BAY1830839 in Healthy Male Participants

Condition: Healthy Volunteers
Interventions: Drug: BAY1830839; Drug: Placebo; Drug: Midazolam; Drug: Methotrexate
Sponsor: Bayer
Recruiting
Safety and Tolerability of Escalating Doses of BPN-14967 in Healthy Adults

Condition: Healthy Volunteers
Interventions: Drug: BPN-14967; Drug: Placebo
Sponsor: Belite Bio, Inc
Recruiting
An Investigational Study to Evaluate Experimental Medication BMS-986165 Given as a Tablet and Solution in Healthy Male Participants

Condition: Healthy Participants
Intervention: Drug: BMS-986165
Sponsor: Bristol-Myers Squibb
Recruiting
A Study of LY3375880 in Healthy Participants

Condition: Healthy
Interventions: Drug: LY3375880 IV; Drug: LY3375880 SC; Drug: Placebo IV; Drug: Placebo SC
Sponsor: Eli Lilly and Company
Completed
A Study of the Absorption, Metabolism, and Excretion of Tucatinib in Healthy Participants

Condition: Healthy
Intervention: Drug: tucatinib
Sponsor: Cascadian Therapeutics Inc.
Completed
Safety, Pharmacokinetic, and Pharmacodynamic Study of TS-142 in Healthy Subjects

Condition: Healthy Volunteer
Interventions: Drug: Step 1: TS-142; Drug: Step 2: TS-142; Drug: Step 2: Placebo
Sponsor: Taisho Pharmaceutical Co., Ltd.
Not yet recruiting
A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics (PK, the Measure of How the Human Body Processes a Substance) of ETX0282 When Administered Orally to Healthy Participants

Condition: Healthy Volunteers
Interventions: Drug: ETX0282; Drug: Cefpodoxime proxetil; Drug: Placebo
Sponsor: Entasis Therapeutics
Active, not recruiting
A Study of 99mTc-3PRGD2 Injection in Healthy Volunteers

Condition: Healthy
Intervention: Drug: 99mTc niacinamide polyethylene glycol bicyclic RGD peptide (99mTc-3PRGD2)
Sponsors: RDO Pharm.; Beijing Pharbers Genesis Pharmaceutical Technology Co., Ltd.; MedAlly Solutions Co., Ltd.
Completed
A Study to Evaluate the PF-06700841 Effect on QTc Interval in Healthy Volunteers

Condition: Healthy
Interventions: Drug: PF-06700841; Drug: Placebo; Drug: moxifloxacin
Sponsor: Pfizer
Completed
A Study Measuring the Effectiveness of BMS-986256 Combined With Oral Contraceptive in Healthy Female Participants

Condition: Healthy Participants
Interventions: Drug: BMS-986256; Drug: Loestrin
Sponsor: Bristol-Myers Squibb
Recruiting
Evaluation of IM Letrozole ISM® Pharmacokinetics, Safety, and Tolerability in Healthy Post-menopausal Women (LISA-1)

Condition: Healthy
Intervention: Drug: Letrozole ISM
Sponsor: Rovi Pharmaceuticals Laboratories
Recruiting
Study for MR Formulation of PF-06650833 in Healthy Adult Japanese Subjects

Condition: Healthy
Interventions: Drug: PF-06650833; Drug: placebo
Sponsor: Pfizer
Completed
A Study to Evaluate the Effect of AG-881 on the Pharmacokinetics of a Single Dose of Lamotrigine in Healthy Adults

Condition: Healthy Participants
Interventions: Drug: AG-881; Drug: Lamotrigine
Sponsor: Agios Pharmaceuticals, Inc.
Recruiting
Comparing of the Pharmacokinetic, Safety and Pharmacodynamic of QL1206 and Xgeva® in Healthy Adults

Condition: Healthy People
Interventions: Drug: QL1206; Drug: Xgeva®
Sponsor: Qilu Pharmaceutical Co., Ltd.
Active, not recruiting
Effects of Perampanel on Neurophysiology Test Perimeters

Condition: Healthy
Intervention: Drug: Perampanel 6 MG
Sponsors: Weill Medical College of Cornell University; Eisai Inc.
Recruiting
THE EFFECT OF MULTIPLE DOSES OF PF-06835919 ON THE PHARMACOKINETICS OF A SINGLE ORAL MIDAZOLAM DOSE IN HEALTHY PARTICIPANTS

Condition: Healthy Volunteer
Interventions: Drug: PF 06835919; Drug: Midazolam
Sponsor: Pfizer
Completed
A Study to Investigate the Effect of Rifampicin on the Uptake and Breakdown of ACT-246475 in Healthy Subjects

Condition: Healthy Subject
Interventions: Drug: Saline; Drug: ACT-246475; Drug: rifampicin
Sponsor: Idorsia Pharmaceuticals Ltd.
Completed
This Study in Healthy Men Tests How Different Doses of BI 1323495 Are Taken up in the Body and How Well They Are Tolerated.

Condition: Healthy
Interventions: Drug: BI 1323495; Drug: Placebo
Sponsor: Boehringer Ingelheim
Completed
Evaluate Taste and Relative Bioavailability of Two Microsphere Formulations of Crizotinib in Healthy Participants

Condition: Healthy Volunteers
Interventions: Drug: Treatment A; Drug: Treatment B; Drug: Treatment C; Drug: Treatment D; Drug: Treatment E; Drug: Treatment F; Drug: Treatment G; Drug: Treatment H
Sponsor: Pfizer
Recruiting
A Trial of IW-1701, A Stimulator of Soluble Guanylate Cyclase (sGC), in Healthy Subjects

Condition: Healthy
Interventions: Drug: IW-1701; Drug: Placebo
Sponsor: Cyclerion Therapeutics
Completed
A Study to Evaluate Drug-Drug Interaction of TAK-788 With Itraconazole and Rifampin in Healthy Adult Participants

Condition: Healthy Volunteers
Interventions: Drug: TAK-788; Drug: Itraconazole; Drug: Rifampin
Sponsor: Millennium Pharmaceuticals, Inc.
Completed
Pharmacokinetic/Pharmacodynamic Characteristics and Safety/Tolerability of MT921 in Healthy Subjects

Condition: Healthy Volunteers
Interventions: Drug: MT921; Drug: Placebo
Sponsor: Medy-Tox
Completed
Study to Evaluate Safety, Tolerability and Pharmacokinetics of rhNGF Eye Drops in Healthy Volunteers

Condition: Healthy
Interventions: Drug: rhNGF 0.5 µg/mL Sentinel; Drug: rhNGF 5 µg/mL Sentinel; Drug: rhNGF 20 µg/mL Sentinel; Drug: rhNGF 20 µg/mL Part A; Drug: rhNGF 60 µg/mL Part A; Drug: rhNGF 180 µg/mL Part A; Drug: rhNGF 20 µg/mL Part B; Drug: rhNGF 60 µg/mL Part B; Drug: rhNGF 180 µg/mL Part B; Drug: Placebo Part A; Drug: Placebo Part B
Sponsors: Dompé Farmaceutici S.p.A; Covance
Completed
Study Investigating a Single Oral Dose of Fenebrutinib in Healthy Volunteers

Condition: Healthy Participants
Intervention: Drug: Fenebrutinib
Sponsor: Hoffmann-La Roche
Completed
A Study to Determine the Effects of PF-04965842 on the Pharmacokinetics of Oral Contraceptive Steroids in Healthy Female Subjects

Condition: Healthy Females
Interventions: Drug: PF-04965842; Drug: Ethinyl estradiol (EE) and levonorgestrel (LN)
Sponsor: Pfizer
Completed
Safety and Tolerability, Pharmacokinetic and Pharmacodynamic Study in Healthy Volunteers

Condition: Healthy
Interventions: Drug: Inzomelid; Drug: Placebo
Sponsor: Inflazome UK Ltd
Recruiting
A Study in Healthy Subjects to Investigate Whether Administration of Clazosentan Can Affect Normal Heart Function

Condition: Healthy Subjects
Interventions: Drug: Clazosentan; Drug: Placebo; Drug: Moxifloxacin
Sponsor: Idorsia Pharmaceuticals Ltd.
Completed
Phase 1, Brain Circuitry Using Blood Oxygen Level Dependent (BOLD) Functional Magnetic Resonance Imaging (fMRI) and Arterial Spin Labeling (ASL) in Healthy Participants

Condition: Healthy Volunteers
Interventions: Drug: Placebo; Drug: BIIB104
Sponsor: Biogen
Not yet recruiting
A Study to Investigate the Effects of Cytochrome P450 1A2 Induction by Ritonavir on BMS-986165 Drug Levels and Effects in Healthy Participants

Condition: Healthy Participants
Interventions: Drug: BMS-986165; Drug: Ritonavir
Sponsor: Bristol-Myers Squibb
Recruiting
Single Ascending Dose Study to Assess the Safety, Tolerability, PK and PD of ONO-4685 in Japanese and Caucasian Healthy Adult Male Subjects

Condition: Healthy Volunteers
Interventions: Biological: ONO-4685; Biological: Placebo; Biological: KLH; Biological: KLH, ONO-4685; Biological: KLH, placebo
Sponsor: Ono Pharmaceutical Co. Ltd
Recruiting
Safety, Tolerability, Pharmacokinetics, and Food Effect of BLU-782 in Healthy Adults

Condition: Healthy Volunteers
Interventions: Drug: BLU-782; Drug: Placebo; Drug: BLU-782 taken with food
Sponsor: Blueprint Medicines Corporation
Recruiting
A Study to Evaluate the Effect of Cyclosporine, a P-Glycoprotein, Breast Cancer Resistance Protein, and Organic-Anion-Transporting Polypeptide Inhibitor, on Pimodivir in Healthy Adults

Condition: Healthy
Interventions: Drug: Pimodivir; Drug: Cyclosporine
Sponsor: Janssen-Cilag International NV
Completed
A Study of Parenterally-administered Teverelix TFA in Healthy Male Volunteers

Condition: Healthy
Intervention: Drug: teverelix TFA
Sponsor: Antev Ltd.
Active, not recruiting
Study to Evaluate the Pharmacokinetics of Mucinex 600 mg Extended-release Bi-layer Tablet in Healthy Volunteers

Condition: Healthy Subjects
Intervention: Drug: Mucinex® ER 600 mg
Sponsor: Reckitt Benckiser Inc.
Completed
A Study In Healthy Male Volunteers Designed To Investigate How A Radiolabelled Medicine Is Broken Down And Removed From The Body

Condition: Healthy Subjects
Intervention: Drug: pracinostat
Sponsors: Helsinn Healthcare SA; Quotient Sciences
Completed
Investigating Accelerated Learning and Memory in Healthy Subjects Using a Face Name Memory Task

Condition: Healthy Adults
Interventions: Device: tDCS; Device: sham tDCS
Sponsor: The University of Texas at Dallas
Active, not recruiting
Study to Investigate the Effect of Balovaptan on the QTC Interval in Healthy Subjects

Condition: Healthy Volunteers
Interventions: Drug: Balovaptan therapeutic dose Treatment A; Drug: Balovaptan supra-therapeutic dose Treatment B; Drug: Active control [moxifloxacin] on Day 2 Treatment C; Drug: Active control [moxifloxacin] on Day 15 Treatment D; Drug: Placebo for Balovaptan Treatment C; Drug: Placebo for Balovaptan Treatment D; Drug: Placebo for Moxifloxacin Treatment A; Drug: Placebo for moxifloxacin Treatment B; Drug: Moxifloxacin Treatment C; Drug: Placebo for moxifloxacin Treatment C; Drug: Placebo for moxifloxacin Treatment D; Drug: Moxifloxacin Treatment D
Sponsor: Hoffmann-La Roche
Completed
Dose Escalating Study of BPI-3016 in Healthy Subjects

Condition: Healthy Subject
Interventions: Drug: BPI-3016; Drug: Placebo
Sponsor: Betta Pharmaceuticals Co., Ltd.
Recruiting
A Clinical Trial to Evaluate Tolerability and Pharmacokinetics of HL217 Eye Drop in Healthy Male Subjects

Condition: Healthy Subject
Interventions: Drug: Cohort 1: HL217 Ophathalmic Solution QD; Drug: Cohort 2: HL217 Ophathalmic Solution BID; Drug: Cohort 3: HL217 Ophthalmic Solution QID; Drug: Placebo Ophthalmic solution
Sponsor: Hanlim Pharm. Co., Ltd.
Completed
An Investigational Study of Experimental Medication BMS-986165 in Healthy Participants

Condition: Healthy Participants
Interventions: Drug: BMS-986165; Drug: MMF
Sponsor: Bristol-Myers Squibb
Completed
Assessment of the Efficacy of Vitamin D-fortified Bread in Healthy Adults

Condition: Healthy
Interventions: Dietary Supplement: fortified bread; Dietary Supplement: supplement; Dietary Supplement: placebo
Sponsor: National Nutrition and Food Technology Institute
Completed
A Study to Look at How Safe NNC0268-0965 is in Healthy People and People With Type 1 Diabetes

Conditions: Diabetes Mellitus, Type 1; Healthy Volunteers
Interventions: Drug: NNC0268-0965; Drug: Placebo; Drug: insulin glargine
Sponsor: Novo Nordisk A/S
Recruiting
Study to Assess the Pharmacokinetics, Safety and Tolerability of Baloxavir Marboxil in Healthy Chinese Participants

Condition: Healthy Volunteer
Intervention: Drug: Baloxavir Marboxil
Sponsors: Hoffmann-La Roche; Shionogi
Completed
A Single Intravenous Dose of E3112 in Japanese Healthy Adult Male Participants

Condition: Healthy Male Participants
Interventions: Drug: E3112; Other: Placebo
Sponsor: EA Pharma Co., Ltd.
Recruiting
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of DWP16001 After Oral Administration in Healthy Male Volunteers

Condition: Healthy
Interventions: Drug: DWP16001; Drug: Placebo; Drug: Dapagliflozin
Sponsor: Daewoong Pharmaceutical Co. LTD.
Completed
A Study in Healthy Men to Find Out How Well Different Doses of BI 764122 Are Tolerated and Whether Food Affects the Amount of BI 764122 in the Blood

Condition: Healthy
Interventions: Drug: BI 764122; Drug: Placebo
Sponsor: Boehringer Ingelheim
Completed
A Single and Multiple Ascending Dose Study of CK-3773274 in Healthy Adult Subjects

Condition: Symptomatic Obstructive Hypertrophic Cardiomyopathy
Interventions: Drug: CK-3773274; Drug: Placebo
Sponsor: Cytokinetics
Recruiting
A Study in Healthy Male Subjects to Investigate Whether Administration of Rifampicin Can Affect the Fate of Clazosentan in the Body of Clazosentan

Condition: Healthy Subjects
Interventions: Drug: Clazosentan; Drug: Rifampicin; Other: Saline (0.9% sodium chloride)
Sponsor: Idorsia Pharmaceuticals Ltd.
Completed
Evaluate Effects of Meropenem-Vaborbactam on QT/QTc in Healthy Volunteers

Condition: Healthy
Interventions: Drug: meropenem-vaborbactam; Drug: Placebo; Drug: Moxifloxacin
Sponsors: Rempex (a wholly owned subsidiary of Melinta Therapeutics, Inc.); Biomedical Advanced Research and Development Authority
Completed
A Phase 1 Study To Investigate The Pharmacokinetics, Safety And Tolerability Of CP-601,927 In Healthy Japanese Subjects

Condition: Healthy
Interventions: Drug: CP-601,927; Drug: Placebo
Sponsor: Pfizer
Withdrawn
Collection of Saliva and/ or Peripheral Blood From Healthy Volunteers for Research

Conditions: Graft vs Host Disease; Healthy Volunteer; Graft-Versus-Host Disease
Intervention:
Sponsor: National Cancer Institute (NCI)
Completed
A Study to Investigate the Effect of CYP3A Inhibition on the Pharmacokinetics of RO7017773 in Healthy Participants

Condition: Healthy Volunteers
Interventions: Drug: RO7017773; Drug: Itraconazole
Sponsor: Hoffmann-La Roche
Completed
ASP8302 Single and Multiple Ascending Oral Dose Study in Non-elderly Healthy Japanese Subjects

Condition: Healthy Subjects
Interventions: Drug: ASP8302; Drug: Placebo
Sponsor: Astellas Pharma Inc
Completed
An Investigational Study of Experimental Medication BMS-986278 Given With the Antibiotic Rifampin in Healthy Participants

Condition: Healthy Participants
Interventions: Drug: BMS-986278; Drug: Rifampin
Sponsor: Bristol-Myers Squibb
Completed
Phase 1 Study to Evaluate ASN002 Absorption, Metabolism, and Excretion of [14C] Following a Single Oral Dose in Healthy Male Subjects

Condition: Healthy Volunteer
Intervention: Drug: [14C] ASN002
Sponsor: Asana BioSciences
Completed
Effects of Tucatinib on Cardiac Repolarization in Healthy Participants

Condition: Healthy
Interventions: Drug: tucatinib; Drug: placebo; Drug: moxifloxacin
Sponsor: Seattle Genetics, Inc.
Completed
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Norketotifen in Healthy Subjects

Condition: Healthy Subjects
Interventions: Drug: Norketotifen Oral Capsule (Cohort 1); Drug: Norketotifen Oral Capsule (Cohort 2); Drug: Norketotifen Oral Capsule (Cohort 3); Drug: Norketotifen Oral Capsule (Multiple Dose Cohort); Drug: Placebo Oral Capsule
Sponsor: Emergo Therapeutics, Inc.
Completed
A Study to Investigate the Interaction Between ACT-246475 and Clopidogrel, Prasugrel, and Ticagrelor in Healthy Subjects

Condition: Healthy
Interventions: Drug: ACT-246475; Drug: Clopidogrel; Drug: Prasugrel; Drug: Placebo; Drug: Ticagrelor
Sponsor: Idorsia Pharmaceuticals Ltd.
Completed
A First in Human Study of the Safety and Tolerability of Single and Multiple Doses of SPR206 in Healthy Volunteers

Condition: Healthy Volunteers
Interventions: Drug: SPR206; Drug: Placebo
Sponsors: Spero Therapeutics; Clinical Network Services (CNS) Pty Ltd
Recruiting
Human Mass Balance Study of HMS5552 in Healthy Subjects

Condition: Healthy Subject
Intervention: Drug: HMS5552
Sponsor: Hua Medicine Limited
Completed
Efgartigimod Co-administered Subcutaneously With rHuPH20 in Healthy Subjects

Condition: Healthy Volunteers
Intervention: Biological: ARGX-113 with rHuPH20
Sponsor: argenx BVBA
Recruiting
Evaluation of Safety and Tolerability of Single Rising Doses of BI 473494 in Healthy Subjects

Condition: Healthy
Interventions: Drug: BI 473494; Drug: Placebo
Sponsor: Boehringer Ingelheim
Terminated
A Study of LY3192767 in Healthy Participants

Condition: Healthy
Interventions: Drug: LY3192767; Drug: Basal Insulin Peglispro; Drug: Insulin Glargine; Drug: Placebo
Sponsor: Eli Lilly and Company
Completed
Evaluate The Safety, Tolerability and Pharmacokinetics Of Multiple Ascending Oral Doses Of WCK 4873 In Healthy Adult Volunteers

Condition: Healthy
Interventions: Drug: WCK 4873; Drug: Placebo Oral Tablet
Sponsor: Wockhardt
Completed
Bioavailability Study of PF-06651600 Formulations in Healthy Participants

Condition: Healthy Volunteers
Intervention: Drug: PF-06651600
Sponsor: Pfizer
Recruiting
Safety and Pharmacokinetics of Vasopressin in Healthy Volunteers

Condition: Healthy Volunteer Safety Study
Intervention: Drug: Vasostrict Injectable Product
Sponsor: Endo Pharmaceuticals
Recruiting
A Study to Investigate Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA Gamma 8) Receptor Occupancy of JNJ-64140284 With Newly Developed Transmembrane AMPA Receptor Regulatory Protein (TARP)-Gamma 8 Positron Emission Tomography (PET) [18F]JNJ-64511070 in Healthy Men

Condition: Healthy
Interventions: Drug: JNJ-64140284; Drug: Fluorine-18 Labeled [18F]-JNJ-64511070
Sponsor: Janssen Research & Development, LLC
Completed
This Study in Healthy Men and Women Tests Whether BI 409306 Has an Effect on the ECG (Thorough QT Study)

Condition: Healthy
Interventions: Drug: BI 409306; Drug: Moxifloxacin; Drug: Placebo matching to BI 409306
Sponsor: Boehringer Ingelheim
Completed
A Study in Healthy Participants to Evaluate the Effects of Multiple Doses of JNJ-55308942 on Cytochrome P450 Substrate Activity and on the Pharmacokinetics of Levonorgestrel/Ethinyl Estradiol

Condition: Healthy
Interventions: Drug: JNJ-55308942 High Dose; Drug: JNJ-55308942 Low Dose; Drug: Levonorgestrel/Ethinyl Estradiol Fixed Dose combination (FDC); Drug: Drug Cocktail:Midazolam (2mg)/Omeprazole (20mg)/Dextromethorphan (30mg)
Sponsor: Janssen-Cilag International NV
Completed
Dual Site-Dual Channel Non-invasive Brain Stimulation for Motor Function in Healthy Subjects

Condition: Healthy
Interventions: Device: M1 stimulation; Device: PMC stimulation; Device: Sham stimulation
Sponsor: Samsung Medical Center
Completed
Studies of Skin Microbes in Healthy People and in People With Skin Conditions

Conditions: Atopic Dermatitis; Eczema; Ichthyosis Vulgaris
Intervention:
Sponsor: National Human Genome Research Institute (NHGRI)
Recruiting
Study to Investigate the Effects of Single Intravenous Doses of Difelikefalin (CR845) on the QTc Interval in Healthy Subjects

Condition: Healthy
Interventions: Drug: CR845 0.5 mcg/kg IV; Drug: CR845 3 mcg/kg IV; Drug: Moxifloxacin 400 mg Oral Tablet; Other: Placebo
Sponsor: Cara Therapeutics, Inc.
Recruiting
A Study to Assess Administration of an Oral Anti-thrombotic With Antiplatelet Therapy in Healthy Subjects

Condition: Healthy Volunteers
Interventions: Drug: BMS-986177; Drug: Aspirin; Drug: Clopidogrel; Drug: Placebo (for BMS-986177)
Sponsor: Bristol-Myers Squibb
Completed
A Safety, Tolerability and Pharmacokinetics Study of TransCon Treprostinil in Healthy Adult Male Volunteers

Condition: Healthy Volunteers
Intervention: Drug: TransCon Treprostinil
Sponsor: Ascendis Pharma A/S
Terminated
Safety and Tolerability Study of LBS-008 in Healthy Adult Subjects After Single and Multiple Doses

Condition: Healthy Volunteer
Interventions: Drug: LBS-008; Drug: Placebos
Sponsors: RBP4 Pty Ltd; Belite Bio, Inc
Recruiting
Evaluation of Neuroinflammation in Parkinson's Disease Using 18F-NOS PET/CT

Conditions: Parkinson Disease; Healthy Volunteer
Intervention: Drug: [18F]NOS
Sponsor: University of Pennsylvania
Recruiting
Effect of Multiple Doses of Itraconazole on the Pharmacokinetics of a Single-Dose of PF-06651600 in Healthy Participants

Condition: Healthy Participants
Interventions: Drug: PF-06651600 10 mg tablets; Drug: Itraconazole Solution 200 mg
Sponsor: Pfizer
Completed
Cerebellar tDCS on Motor Learning of Healthy Individuals

Condition: Healthy
Intervention: Device: tDCS
Sponsor: Universidade Federal de Pernambuco
Completed
A Study to Investigate the Bioequivalence of Two Different Forms of Entrectinib (Forms A and C) Under Fasted Conditions in Healthy Subjects

Condition: Healthy Volunteers
Interventions: Drug: Entrectinib Form A; Drug: Entrectinib Form C
Sponsor: Genentech, Inc.
Completed
Phase 1 TAK-925 Study in Healthy Adult and Elderly Volunteers and Patients With Narcolepsy

Condition: Healthy Participants and Patients With Narcolepsy
Interventions: Drug: TAK-925; Drug: Placebo
Sponsor: Takeda
Completed
Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of After Administrations of DWP14012 Alone and Combinations of DWP14012, Clarithromycin and Amoxicillin in Healthy Male Subjects

Condition: Healthy
Interventions: Drug: DWP14012 Amg; Drug: DWP14012 Bmg; Drug: Clarithromycin; Drug: Amoxicillin; Drug: Lansoprazole
Sponsor: Daewoong Pharmaceutical Co. LTD.
Completed
Bioequivalence Study of Ibuprofen D, Oral Suspension, 200 mg/5ml and Nurofen®, Oral Suspension 100 mg/5 ml in Healthy Volunteers Under Fasting Conditions

Condition: Healthy
Interventions: Drug: Ibuprofen D; Drug: Nurofen® for Children
Sponsors: Pharmtechnology LLC; ClinPharmInvest, LLC
Completed
A Study of Bedaquiline 100 Milligram (mg) Tablets Administered as Different Test Formulations Compared to the Commercial Tablet Formulation (F001) in Healthy Adult Participants

Condition: Healthy
Interventions: Drug: Bedaquiline (Test formulation); Drug: Bedaquiline (Reference formulation)
Sponsor: Janssen Research & Development, LLC
Not yet recruiting
A Study of Experimental Medication BMS-986278 Given to Healthy Participants

Condition: Healthy Participants
Interventions: Drug: BMS-986278; Other: Placebo
Sponsor: Bristol-Myers Squibb
Active, not recruiting
A Study of AST-008 in Healthy Subjects

Condition: Healthy Volunteer Study
Intervention: Drug: AST-008
Sponsor: Exicure, Inc.
Completed
An Investigational Study to Evaluate the Effects of Experimental Medication BMS-986256 in Healthy Participants

Condition: Healthy Participants
Interventions: Drug: BMS-986256; Other: Placebo
Sponsor: Bristol-Myers Squibb
Recruiting
Sleep, Nutrition and Psychological Functioning in Kindergarten Children

Condition: Prevention Harmful Effects
Interventions: Behavioral: Healthy Sleep intervention; Behavioral: Healthy Nutrition intervention
Sponsors: Tel Aviv University; Israel Science Foundation
Active, not recruiting
Neurophysiological Correlates of Cognitive Tasks in Healthy Volunteers -WP3 P003

Conditions: Alzheimer Disease; ELECTROENCEPHALOGRAPHIC VARIANT PATTERN 1 (Disorder)
Intervention: Other: Rapid Visual Information Processing (RVIP) test
Sponsor: University Hospital, Lille
Recruiting
Study to Evaluate the Safety, Tolerability, PK and PD of PB2452 in Healthy Younger, Older and Elderly Subjects

Condition: Healthy
Interventions: Drug: PB2452 Infusion; Drug: Placebo - Sodium Chloride; Drug: Ticagrelor Oral Tablet - Pre-Treatment; Drug: Ticagrelor Oral Tablet - Pre-Treatment and Post-Treatment
Sponsor: PhaseBio Pharmaceuticals Inc.
Recruiting
Dual Site-Dual Channel Non-invasive Brain Stimulation for Language and Cognitive Function in Healthy Subjects

Condition: Healthy
Interventions: Device: IFG stimulation; Device: DLPFC stimulation; Device: Sham stimulation
Sponsor: Samsung Medical Center
Completed
Metabolic Availability of Methionine From Mung Beans in Healthy Young Adult Men

Condition: Healthy
Intervention: Other: Dietary Intakes
Sponsor: The Hospital for Sick Children
Recruiting
A PK Study GL2702 GLARS-NF1 and Omix Ocas® in Healthy Male Volunteers

Condition: Healthy
Interventions: Drug: GL2702 GLARS-NF1; Drug: Omix Ocas
Sponsor: GL Pharm Tech Corporation
Completed
Double-Blind Randomized Controlled Trial for the Evaluation of a Novel Adaptive Attention Training in Healthy Adolescents

Condition: Healthy Adolescents
Interventions: Behavioral: Adaptive Attention Training; Behavioral: Active Control; Behavioral: Low-dose Adaptive Attention Training
Sponsors: University of California, San Francisco; Alliance for Decision Education
Recruiting
Study to Learn More About the Effect of Itraconazole (ITZ) Given Repeatedly by Mouth on the Way How the Study Drug BAY1902607 Given One Time by Mouth Acts in the Human Body of Healthy Male Participants

Condition: Drug Interactions
Interventions: Drug: BAY1902607; Drug: Itraconazole
Sponsor: Bayer
Completed
Comparative Clinical Trial to Evaluate Bioequivalency and Safety of Monoclonal Antibody Injection and Adalimumab in Chinese Healthy Volunteers

Condition: Healthy
Interventions: Drug: human recombinant anti-tumor necrosis factor alpha monoclonal antibody injection; Drug: adalimumab
Sponsor: Innovent Biologics (Suzhou) Co. Ltd.
Completed
Clinical Trial Testing the BioSerenity Pulse Oximeter (EOXY) Efficacy, Performance and Safety in Healthy Volunteer

Condition: Healthy
Interventions: Device: EOXY device; Device: Gold standard oximeter; Procedure: SaO2 sampling
Sponsors: BioSerenity; NAMSA; Université Catholique de Louvain
Completed
A Study To Evaluate The Effect Of PF-04447943 On Qtc Interval In Healthy Adult Subjects

Condition: Healthy
Interventions: Drug: PF-04447943; Drug: Placebo; Drug: Moxifloxacin
Sponsor: Pfizer
Completed
Study to Determine the Single and Repeat Dose Pharmacokinetics, Food Effect, Proton Pump Inhibitor (PPI) Drug Interaction, Safety and Tolerability of Oral Prototype Formulations of BOS172767 in Healthy Subjects

Condition: Healthy Subjects
Interventions: Drug: BOS172767 tablets; Drug: BOS172767 liquid capsules; Drug: BOS172767 micronized capsules; Drug: BOS172767 immediate release capsules; Drug: BOS172767 matching placebo capsules; Drug: BOS172767 matching placebo tablets; Drug: Rabeprazole
Sponsor: Boston Pharmaceuticals
Completed
A Single and Multiple-Ascending Dose Study of CRN01941 in Healthy Adult Volunteers

Condition: Healthy Volunteers
Interventions: Drug: CRN01941 Oral Solution; Drug: CRN01941 Oral Capsule; Drug: Placebo Oral Solution; Drug: Placebo Oral Capsule
Sponsor: Crinetics Pharmaceuticals Inc.
Recruiting
Phase I Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of OSE-127 in Healthy Subjects

Condition: Healthy Subjects
Interventions: Drug: OSE-127; Drug: Placebo
Sponsors: OSE Immunotherapeutics; Servier
Recruiting
A Study to Investigate the Relative Bioavailability of Entrectinib Capsule Formulations F1 and F06 Under Fed Conditions in Healthy Participants

Condition: Healthy Volunteers
Interventions: Drug: Entrectinib Test Formulation (F1); Drug: Entrectinib Reference Formulation (F06)
Sponsor: Genentech, Inc.
Recruiting
This Study in Healthy Men Tests How Different Doses of BI 1358894 Are Taken up in the Body and How Well They Are Tolerated. The Study Also Tests How BI 1358894 Affects the Way the Body Breaks Down Midazolam

Condition: Healthy
Interventions: Drug: BI 1358894; Drug: Placebo; Drug: Midazolam
Sponsor: Boehringer Ingelheim
Completed
A Study to Assess the Electrophysiology, Safety, Tolerability, and Pharmacokinetics of SAGE-718 Using a Ketamine Challenge in Healthy Subjects

Condition: Healthy Volunteer
Interventions: Drug: SAGE-718; Drug: Placebo
Sponsor: Sage Therapeutics
Completed
A Study to Investigate the Effect of JNJ-64565111 on Cardiac Repolarization (Corrected QT Interval) Compared With Placebo in Healthy Adults: a Thorough ECG Study Employing Placebo, JNJ-64565111, and a Positive Control (Moxifloxacin)

Condition: Healthy
Interventions: Drug: JNJ-64565111; Drug: Moxifloxacin; Drug: JNJ-64565111-matching Placebo; Drug: Moxifloxacin-matching Placebo
Sponsor: Janssen Research & Development, LLC
Completed
A Study to Evaluate Safety, Tolerability, and Distribution of a Microdose of Radiolabeled BIIB067 (99mTc-MAG3-BIIB067) Co-administered With BIIB067 to Healthy Adults

Condition: Healthy Volunteers
Interventions: Drug: BIIB067; Drug: 99mTc-MAG3-BIIB067
Sponsor: Biogen
Active, not recruiting
Pharmacokinetics, Safety, and Tolerability Study of the Pen and PFS of SB5 in Healthy Subjects

Condition: Healthy
Interventions: Biological: Pen of SB5; Biological: PFS of SB5
Sponsor: Samsung Bioepis Co., Ltd.
Completed
A Phase I Study Evaluating the Safety, Tolerability, PK and PD in Healthy Chinese Volunteers

Condition: Healthy Chinese Volunteers
Interventions: Drug: HBM9161(HL161BKN); Drug: Placebo
Sponsor: Harbour BioMed (Guangzhou) Co. Ltd.
Recruiting
A Bioequivalence Study of Losartan Potassium Tablets (Containing Losartan Potassium 100 mg) in Normal, Healthy, Adults Under Fasting Conditions

Condition: Healthy
Interventions: Drug: Cozaar 100mg Tablet; Drug: Losartan potassium 100mg
Sponsors: Pharmtechnology LLC; Reliance Life Sciences Private Limited
Completed
Safety and Immunogenicity of Takeda's TDV in Healthy Children

Condition: Healthy Volunteers
Intervention: Biological: Tetravalent Dengue Vaccine Candidate
Sponsor: Takeda
Active, not recruiting
Anti-Shiga Toxin Hyperimmune Equine Immunoglobulin F(ab')2 Fragment (INM004) in Healthy Volunteers

Condition: Healthy Volunteers
Interventions: Biological: Drug: INM004 Dose 1; Biological: Drug: INM004 Dose 2; Biological: Drug: INM004- Repeated dose; Other: Placebo
Sponsors: Inmunova S.A.; Hospital Italiano de Buenos Aires
Completed
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics After Single and Multiple Doses of LEO 142397 in Healthy People, Including Japanese

Condition: Healthy
Interventions: Drug: LEO 142397; Drug: Placebo
Sponsor: LEO Pharma
Withdrawn
WD-1603 PK Study in Healthy Volunteers

Condition: Healthy Volunteers
Intervention: Drug: carbidopa-levodopa
Sponsor: Hong Kong WD Pharmaceutical Co., Limited
Not yet recruiting
A Pharmacokinetic Study of TAK-438 in Healthy Adult Chinese Participants

Condition: Healthy Participants
Intervention: Drug: TAK-438
Sponsor: Takeda
Completed
A Study to Assess Electrophysiology, Safety, Tolerability, and Pharmacokinetics of Multiple Doses of SAGE-718 Using Ketamine Challenge in Healthy Subjects

Condition: Healthy Volunteer
Interventions: Drug: SAGE-718; Drug: Placebo
Sponsor: Sage Therapeutics
Completed
Pharmacokinetic, Safety and Immunogenicity Study of CMAB009 and Herceptin in Healthy Volunteers

Condition: Healthy Volunteers
Interventions: Drug: CMAB809; Drug: Trastuzumab
Sponsor: Taizhou Mabtech Pharmaceutical Co.,Ltd
Recruiting
A Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Study of BIIB091, a Bruton's Tyrosine Kinase (BTK) Inhibitor, in Healthy Adult Participants

Condition: Healthy Volunteer
Interventions: Drug: BIIB091; Drug: Placebo
Sponsor: Biogen
Recruiting
Effect of B-GOS on the Wellbeing and Ageing in Healthy 52-65 Years Old Individuals

Condition: Healthy
Interventions: Dietary Supplement: B-GOS; Dietary Supplement: Maltodextrin
Sponsors: Clasado Limited; General Hospital, States of Jersey
Completed
Beta-hCG Test Reference Range Determination

Condition: Healthy
Intervention:
Sponsor: Response Biomedical Corp.
Terminated
Bioequivalence Study Comparing Mucinex Extended-release 600 mg Tablets to Immediate-release Guaifenesin 600 mg in Healthy Volunteers

Condition: Healthy Subjects
Interventions: Drug: Mucinex® SE; Drug: Vicks Cough Syrup for Chesty Coughs
Sponsor: Reckitt Benckiser Inc.
Completed
Evaluation of Safety of Repeated Doses of OP0201 Metered Dose Inhaler Compared to Placebo in Healthy Adult Volunteers

Condition: Healthy Adult Volunteers
Interventions: Combination Product: Drug: OP0201; Combination Product: Drug: Placebo
Sponsor: Novus Therapeutics, Inc
Completed
A Single Ascending Dose Escalation to Investigate Safety and PK of VVZ-149 Injection in Healthy Older Male Volunteers

Condition: Healthy
Interventions: Drug: VVZ-149 injection; Other: Placebo
Sponsor: Vivozon, Inc.
Completed
The Influence of Histo-blood Group Antigen Polymorphism on the Composition of the Microbiota

Condition: Microbiota Analysis in Healthy Subjects
Intervention: Other: Healthy Adults
Sponsors: University of Florida; National Institute of Allergy and Infectious Diseases (NIAID)
Withdrawn
A Study to Investigate the Effect of Multiple Doses of Itraconazole on the Pharmacokinetics of PF-06700841 in Healthy Participants

Condition: Healthy Participants
Interventions: Drug: PF-06700841; Drug: Itraconazole
Sponsor: Pfizer
Not yet recruiting
Study to Evaluate the Effect of Omeprazole on the Pharmacokinetics of SPD422 (Anagrelide Hydrochloride) in Healthy Adult Participants

Condition: Healthy Volunteers
Interventions: Drug: SPD422; Drug: Omeprazole
Sponsor: Shire
Completed
A Study to Evaluate if ID-085 is Safe, Its Fate in the Body as Well as Its Potential Effects on the Body in Healthy Subjects

Condition: Healthy Subjects
Interventions: Drug: ID-085; Drug: Placebo oral capsule
Sponsor: Idorsia Pharmaceuticals Ltd.
Completed
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of DWP14012 After Oral Administration in Healthy Japanese, Caucasian and Korean

Condition: Healthy Volunteers
Interventions: Drug: DWP14012; Drug: Placebo
Sponsor: Daewoong Pharmaceutical Co. LTD.
Completed
A Study to Evaluate Central Nervous System (CNS) Pharmacodynamic Activity of TAK-653 in Healthy Participants Using Transcranial Magnetic Stimulation (TMS)

Condition: Healthy Volunteers
Interventions: Drug: TAK-653; Drug: Placebo; Drug: Ketamine
Sponsor: Millennium Pharmaceuticals, Inc.
Completed
This Study is Done in Healthy Japanese Volunteers. It Looks at How Different Doses of BI 705564 Are Taken up in the Body and How Well They Are Tolerated

Condition: Healthy
Interventions: Drug: BI 705564; Drug: Placebo
Sponsor: Boehringer Ingelheim
Withdrawn
Comparison of Pulse Wave and Blood Pressure Measurements Before, During and After Ergometry in Healthy Men

Condition: Healthy Male Subjects
Interventions: Other: Ergometry H; Other: Ergometry L
Sponsors: ARCIM Institute Academic Research in Complementary and Integrative Medicine; Universität Tübingen
Completed
Randomised, Controlled Study to Assess Safety and Tolerance of Infant Formula With Prebiotics and Postbiotics in Healthy Infants.

Condition: Healthy Term Infants
Intervention: Other: milk based infant formula
Sponsor: Nutricia Research
Not yet recruiting
A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of RO7062931 in Healthy Chinese Volunteers.

Condition: Healthy Participants
Interventions: Drug: RO7062931; Drug: Placebo
Sponsor: Hoffmann-La Roche
Completed
Anthocyanin Dose-escalation Study in Healthy Young Adults

Condition: Healthy
Interventions: Dietary Supplement: Anthocyanin; Dietary Supplement: Placebo
Sponsors: Shaoguan University; Sun Yat-sen University
Completed
New Infant Formula Supports Adequate Growth in Healthy Infants

Condition: Infant Development
Interventions: Other: Formula A; Other: Formula B
Sponsor: Worthy Health
Not yet recruiting
Intervention With a Progressive Web App for the Promotion of Healthy Habits in Preschoolers

Condition: Health Behavior
Intervention: Other: Progressive web app
Sponsor: Universidad Peruana Cayetano Heredia
Completed
A Study to Evaluate Safety, Tolerability and Pharmacokinetics of Ascending Oral Single Dose of TAK-418 in Healthy Participants

Condition: Healthy Participants
Interventions: Drug: TAK-418; Drug: TAK-418 Placebo
Sponsor: Takeda
Completed
A Study to Demonstrate the Equivalent Pharmacokinetic Properties of a Single Intravenous Dose of HD201 and EU-Herceptin® and US-Herceptin® in Healthy Male Subjects

Condition: Healthy Volunteers
Interventions: Drug: HD201; Drug: EU-Herceptin; Drug: US-Herceptin
Sponsor: Prestige Biopharma Pte Ltd
Completed
COMPARİSON OF HEART FAİLURE PATİENTS AND HEALTHY PEOPLE İN BALANCE AND GAİT PARAMETERS

Condition: Heart Failure,Balance
Intervention:
Sponsor: Hacettepe University
Enrolling by invitation
Assess the Safety and Tolerability of Single and Multiple Ascending Doses of Oral RO7020531 in Chinese Healthy Participants

Condition: Healthy Participants
Interventions: Drug: RO7020531; Other: Placebo
Sponsor: Hoffmann-La Roche
Completed
Study to Assess the Safety, Tolerability, and Pharmacokinetics of E2082 in Healthy Male Subjects

Condition: Healthy Participants
Interventions: Drug: E2082; Drug: Placebo
Sponsor: Eisai Co., Ltd.
Suspended
A Study to Assess the Safety, Tolerability, and Pharmacokinetics of Ascending, Subcutaneous, Single and Multiple Doses of SHP681 (Glucagon-like Peptide-2 [GLP-2] Analog-Fc Fusion) in Healthy Adult Participants

Condition: Healthy Volunteers
Interventions: Drug: SHP681; Other: Placebo
Sponsor: Shire
Recruiting
This Study is Done in Healthy Japanese Volunteers. It Looks at How Different Doses of BI 730357 Are Taken up in the Body and How Well They Are Tolerated

Condition: Healthy
Interventions: Drug: BI 730357; Drug: Placebo
Sponsor: Boehringer Ingelheim
Completed
Comparison of Pulse Wave and Blood Pressure Measurements Before, During and After Ergometry in Healthy Women

Condition: Healthy Female Subjects
Interventions: Other: Ergometry H; Other: Ergometry L
Sponsors: ARCIM Institute Academic Research in Complementary and Integrative Medicine; Universität Tübingen
Completed
A First in Human Study to Assess the Safety, Tolerability and Immunogenicity of a Single Dose of a Trivalent Inactivated Poliovirus Vaccine Based on Sabin Strains (sIPV) Given Intramuscularly in Healthy Adults

Condition: Healthy
Interventions: Biological: sIPV; Biological: cIPV
Sponsor: Janssen Vaccines & Prevention B.V.
Completed
A Study to Determine the Bioavailability of Lanadelumab (SHP643) Administered Subcutaneously With the Prefilled Syringe and the Autoinjector in Healthy Adult Volunteer Participants.

Condition: Healthy Volunteers
Intervention: Drug: SHP643
Sponsor: Shire
Recruiting
Study of ITI-214 in Healthy Volunteers to Determine CNS Engagement

Condition: Healthy Volunteers
Interventions: Drug: ITI-214; Drug: Placebo
Sponsors: Intra-Cellular Therapies, Inc.; Laureate Institute for Brain Research, Inc.
Active, not recruiting
A Study to Investigate the Effect of RO7049389 on the Pharmacokinetics of Pitavastatin in Healthy Volunteers

Condition: Healthy Volunteers
Interventions: Drug: RO7049389; Drug: Pitavastatin
Sponsor: Hoffmann-La Roche
Completed
A Study Investigating the Excretion Balance, Pharmacokinetics and Metabolism of a Single Oral Dose of [14C]-Labeled Risdiplam (RO7034067) in Healthy Male Participants

Condition: Healthy
Intervention: Drug: [^14C]-Risdiplam
Sponsor: Hoffmann-La Roche
Completed
Study of TJ003234 (Anti-GM-CSF Monoclonal Antibody) in Healthy Adult Subjects

Condition: Healthy Adult Subjects
Interventions: Drug: TJ003234; Drug: Placebo
Sponsor: I-Mab Biopharma Co. Ltd.
Active, not recruiting
A Study to Evaluate the Pharmacokinetics of Dexlansoprazole 30 Milligram (mg) and 60 mg Delayed-release Capsules in Healthy Chinese Participants

Condition: Healthy Volunteers
Intervention: Drug: Dexlansoprazole
Sponsor: Takeda
Completed
A Study of Abemaciclib in Healthy Participants

Condition: Healthy
Interventions: Drug: Abemaciclib; Drug: Placebo; Drug: Loperamide
Sponsor: Eli Lilly and Company
Completed
Collection of Blood, Bone Marrow, and Buccal Mucosa Samples From Healthy Volunteers for Center for Human Immunology, Autoimmunity, and Inflammatory Diseases (CHI) Laboratory Research Studies

Condition: Healthy Volunteers
Intervention:
Sponsor: National Heart, Lung, and Blood Institute (NHLBI)
Completed
A Study To Understand How The Body Reacts To A Low Dose Of PF‑06427878 When Given In A Vein To Healthy, Adult, Males

Condition: Healthy
Intervention: Drug: PF-06427878
Sponsor: Pfizer
Completed
A Trial to Demonstrate the Equivalent Pharmacokinetic Properties of HD204 and Bevacizumab (Avastin®) in Healthy Male Subjects

Condition: Healthy Volunteers
Interventions: Drug: HD204; Drug: Avastin
Sponsor: Prestige Biopharma Pte Ltd
Completed
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK), and Pharmacodynamics (PD) of Single and Multiple Oral Dose of TAK-418 in Healthy Female Participants

Condition: Healthy Volunteers
Interventions: Drug: TAK-418; Drug: TAK-418 Matching Placebo
Sponsor: Takeda
Terminated
A Study to Determine the Bioavailability of Various Formulations of GDC-0134 in Healthy Female Participants of Non-Childbearing Potential

Condition: Healthy Volunteers
Interventions: Drug: GDC-0134 F09 Formulation; Drug: GDC-0134 F15 Formulation; Drug: GDC-0134 F16 Formulation
Sponsor: Genentech, Inc.
Completed
Dolcanatide in Preventing Colorectal Cancer in Healthy Volunteers

Condition: Healthy Subject
Interventions: Drug: Dolcanatide; Other: Laboratory Biomarker Analysis; Other: Placebo; Other: Questionnaire Administration
Sponsor: National Cancer Institute (NCI)
Active, not recruiting
This Study is Done in Healthy Japanese Volunteers. It Looks at How Different Doses of BI 1015550 Are Taken up in the Body and How Well They Are Tolerated.

Condition: Healthy
Interventions: Drug: BI 1015550; Drug: Placebo
Sponsor: Boehringer Ingelheim
Completed
Single-dose Novel Selective alpha2c Antagonist Pharmaco-MRI Study in Healthy Volunteers

Condition: Healthy Volunteer
Interventions: Drug: ORM-12741; Drug: Placebo
Sponsors: University of Cape Town; Orion Corporation, Orion Pharma; University of Oxford
Completed
Study to Determine the Effect of Food on the Blood Levels of AST2818 Following Single Oral Doses in Healthy Male Volunteers

Condition: Healthy Male Volunteers
Intervention: Drug: AST2818 Tablets
Sponsor: Allist Pharmaceuticals, Inc.
Active, not recruiting
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of IONIS-PKK-LRx Administered Subcutaneously to Healthy Volunteers

Condition: Healthy Volunteers
Interventions: Drug: Placebo; Drug: IONIS PKK-LRx
Sponsor: Ionis Pharmaceuticals, Inc.
Completed
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of TAK-925 Study in Sleep-Deprived Healthy Adults

Condition: Healthy Volunteers
Interventions: Drug: TAK-925; Drug: TAK-925 Placebo; Drug: Modafinil; Drug: Modafinil Placebo
Sponsor: Takeda
Completed
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of GDC-0853 in Healthy Japanese and Caucasian Participants

Condition: Healthy Volunteer
Interventions: Drug: GDC-0853; Drug: Placebo
Sponsor: Hoffmann-La Roche
Completed
Pharmacokinetic, Safety, Tolerability and Immunogenicity Study of SB5 in Healthy Subjects

Condition: Healthy
Interventions: Biological: SB5; Biological: EU sourced Humira®; Biological: US sourced Humira®
Sponsor: Samsung Bioepis Co., Ltd.
Completed
A Study to Evaluate ACT-246475 Fate in Healthy Male Subjects

Condition: Healthy Subjects
Intervention: Drug: ACT-246475
Sponsor: Idorsia Pharmaceuticals Ltd.
Completed
A Study to Assess the Electrophysiology, Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Response Using Magnetic Resonance Imaging of SAGE-718 Using a Ketamine Challenge in Healthy Subjects

Condition: Healthy Volunteer
Interventions: Drug: SAGE-718; Drug: Placebo
Sponsor: Sage Therapeutics
Completed
A Study to Investigate the Effect of Rifampicin on the PK of Multiple Doses of Balovaptin In Healthy Volunteers

Condition: Healthy Volunteers
Interventions: Drug: Balovaptan; Drug: Rifampicin
Sponsor: Hoffmann-La Roche
Completed
Healthy Caregivers-Healthy Children (HC2) Phase II

Conditions: Pediatric Obesity; Obesity
Interventions: Behavioral: Healthy Caregivers- Healthy Children Toolkit; Behavioral: Safety Curriculum
Sponsor: University of Miami
Completed
A Study Investigating the Absolute Oral Bioavailability of Balovaptan After Single and Multiple Daily Oral Doses of Balovaptan in Healthy Volunteers

Condition: Healthy Volunteers
Interventions: Drug: Oral Balovaptan; Drug: IV Balovaptan
Sponsor: Hoffmann-La Roche
Completed
A Study to Investigate the Effect of Itraconazole on the PK of Multiple Doses of Balovaptan in Healthy Volunteers

Condition: Healthy Volunteers
Interventions: Drug: Balovaptan; Drug: Itraconazole
Sponsor: Hoffmann-La Roche
Completed
A MAD Study of TT301/MW189 in Healthy Volunteers

Condition: Healthy Adult Volunteers
Interventions: Drug: Cohort 1 - TT301/MW189; Drug: Cohort 2- TT301MW189; Drug: Cohort 3 - TT301/MW189; Other: Cohort 1 Placebo; Other: Cohort 2 Placebo; Other: Cohort 3 Placebo; Drug: Cohort 4 - TT301/MW189; Other: Cohort 4 Placebo
Sponsors: Linda Van Eldik; Duke Clinical Research Institute; Alzheimer's Association
Active, not recruiting
Sublingual Microcirculation of Healthy Volunteers by Using the Third Generation Microcirculation Video Microscope

Condition: Healthy
Intervention:
Sponsor: National Taiwan University Hospital
Completed
First-in-Human Study With Single and Multiple Doses of TS-161 in Healthy Participants

Condition: Healthy Volunteers
Interventions: Drug: TS-161; Drug: TS-161 Placebo
Sponsor: Taisho Pharmaceutical R&D Inc.
Recruiting
A Study of Safety, Tolerability, and Pharmacokinetics of Single Doses of PHP-303 in Healthy Subjects

Condition: Healthy Volunteer
Interventions: Drug: PHP-303; Other: Placebo
Sponsor: pH Pharma
Completed
A Study to Assess the Relative Bioavailability of Roxadustat Following a Single Dose of Pediatric Azo Dye-free Tablet Formulation and Pediatric Azo Dye-free Mini-tablet Formulation Compared to a Single Dose of Azo Dye-containing Tablet Formulation in Healthy Adult Subjects

Condition: Healthy Adult Subjects
Interventions: Drug: Roxadustat Tablet; Drug: Roxadustat Mini-tablet
Sponsors: Astellas Pharma Global Development, Inc.; FibroGen
Recruiting
A First-In-Human Study With a Single Ascending Dose of UCB7858 in Healthy Volunteers

Condition: Healthy Volunteers
Interventions: Drug: UCB7858; Drug: Placebo
Sponsor: UCB Biopharma S.P.R.L.
Completed
Complement 2: Blood Donations to Develop Vaccines Against Infectious Diseases

Condition: Complement Mediated Bacterial Killing in Healthy Adults
Intervention:
Sponsors: University of Oxford; Wellcome Trust
Active, not recruiting
A Study to Test the Safety and Tolerability and Pharmacokinetics of Single Doses of UCB0107 in Healthy Japanese Subjects

Condition: Healthy Japanese Volunteers
Interventions: Drug: UCB0107; Other: Placebo
Sponsor: UCB Biopharma S.P.R.L.
Completed
A Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Risdiplam (RO7034067) in Healthy Japanese Participants

Condition: Healthy Volunteers
Interventions: Drug: Risdiplam; Drug: Placebo
Sponsor: Hoffmann-La Roche
Completed
Pharmacokinetic, Safety, and Tolerability Study of Intranasally Administered Esketamine in Healthy Han Chinese, Korean, Japanese, and Caucasian Participants and the Effects of Rifampin on the Pharmacokinetics of Intranasally Administered Esketamine

Condition: Healthy
Interventions: Drug: Esketamine; Drug: Rifampin
Sponsor: Janssen Research & Development, LLC
Completed
A Study to Evaluate the Effects of Single and Multiple Oral Doses of GLPG3667

Condition: Healthy
Interventions: Drug: GLPG3667; Drug: Placebos
Sponsor: Galapagos NV
Recruiting
Study to Evaluate the Abuse Potential of ACT-541468 in Healthy Recreational Drug Users

Condition: Healthy Recreational Drug Users
Interventions: Drug: ACT-541468; Drug: Suvorexant; Drug: Zolpidem; Drug: Placebo
Sponsor: Idorsia Pharmaceuticals Ltd.
Completed
A Study to Investigate the Effects of Cortexolone 17α-propionate (and Its Metabolites) on Healthy Volunteers' Heart

Condition: Healthy Volunteers
Interventions: Drug: Cortexolone 17α-propionate solution; Drug: Placebo
Sponsor: Cassiopea SpA
Completed
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ACT-451840 in Healthy Subjects (Part A)

Condition: Healthy
Interventions: Drug: ACT-451840 10 mg; Drug: ACT-451840 50 mg; Drug: ACT-451840 200 mg; Drug: ACT-451840 500 mg; Drug: ACT-451840 1000 mg; Drug: ACT-451840 (Dose to be determined); Drug: Placebo
Sponsor: Idorsia Pharmaceuticals Ltd.
Completed
Pharmacokinetic, Safety, Tolerability and Immunogenicity Study of SB2 in Healthy Subjects

Condition: Healthy
Interventions: Biological: SB2; Biological: EU Remicade; Biological: US Remicade
Sponsor: Samsung Bioepis Co., Ltd.
Completed
A Study to Determine the Bioequivalence of Alogliptin and Pioglitazone When Administered as Individual Tablets and as Fixed-Dose Combination (FDC)-SYR-322-4833 BL Tablets to Healthy Russian Participants

Condition: Healthy Volunteers
Interventions: Drug: Alogliptin; Drug: Pioglitazone; Drug: SYR-322-4833 BL
Sponsor: Takeda
Completed
A Single Intravenous Dose Study of E3112 in Japanese Healthy Adult Male Subjects

Condition: Healthy Male Volunteers
Interventions: Drug: Placebo; Drug: E3112
Sponsor: EA Pharma Co., Ltd.
Completed
Investigation of Thermal Injury on Intestinal Permeability in Both Thermal Injury and Healthy Participants

Condition: Burns
Interventions: Other: Lactulose and Mannitol solution; Other: Sucralose
Sponsor: GlaxoSmithKline
Terminated
Safety and Immunogenicity of Ad4-HIV Envelope Vaccine Vectors in Healthy Volunteers

Condition: Healthy Volunteer
Interventions: Biological: Ad4-Env145NFL; Biological: Ad4-Env150KN; Biological: VRC-HIVRGP096-00-VP (Trimer 4571) with alum
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting
Intranasal Insulin and Olanzapine Study in Healthy Volunteers

Condition: Healthy Controls
Interventions: Drug: OLANZapine 2.5 MG; Drug: Placebo; Drug: Insulin Lispro 100 UNT/ML; Other: Saline
Sponsors: Centre for Addiction and Mental Health; University Health Network, Toronto
Not yet recruiting
A Phase 1 Study To Evaluate The Effect Of Glasdegib On The Cardiac Repolarization In Healthy Subjects

Condition: Healthy Volunteers
Interventions: Drug: Glasdegib Therapeutic Exposure; Drug: Glasdegib Supra-therapeutic Exposure; Drug: Positive Control (Moxifloxacin); Other: Placebo Control
Sponsor: Pfizer
Completed
A Dose-escalation Clinical Trial After Multiple Dosing of HL217 Eye Drop in Healthy Male Subjects

Condition: Healthy Subjects
Interventions: Drug: Cohort 1: HL217 Ophathalmic Solution BID; Drug: Cohort 2: HL217 Ophathalmic Solution QID; Drug: Placebo
Sponsor: Hanlim Pharm. Co., Ltd.
Completed
Single Oral Dose of 4 mg Cenerimod in Healthy Japanese and Caucasian Subjects

Condition: Healthy Volunteers
Interventions: Drug: Cenerimod; Drug: Matching Placebo
Sponsor: Idorsia Pharmaceuticals Ltd.
Recruiting
Effects of Cerebral and Peripheral Electrical Stimulation on Conditioned Pain Modulation in Healthy Subjects.

Condition: Healthy Volunteers
Interventions: Procedure: Transcranial direct current stimulation (tDCS); Procedure: Peripheral electrical stimulation (PES); Procedure: Sham tDCS
Sponsor: Universidade Federal do Piauí
Recruiting
A Study to Evaluate the Effect of Increased Stomach pH on Evacetrapib in Healthy Participants

Condition: Healthy
Interventions: Drug: Evacetrapib; Drug: Omeprazole
Sponsor: Eli Lilly and Company
Completed
A Family-Focused Intervention for Asian American Male Smokers

Conditions: Smoking Cessation; Family; Health Behavior
Interventions: Behavioral: Quit Smoking for a Healthy Family; Behavioral: Healthy Living
Sponsors: University of California, San Francisco; University of California, Davis; Chinese Community Health Resource Center; Immigrant Resettlement & Cultural Center; Vietnamese Voluntary Foundation, Inc.; Southeast Asian Community Center
Active, not recruiting
Healthy Frio: A Rural Community Partnership to Advance Latino Obesity Research

Conditions: Obesity; Nutrition Poor; Physical Activity; Weight Loss
Interventions: Behavioral: Healthy Frio In-Person Family-focused Intervention; Behavioral: Healthy Frio Remote Technology Family-focused Intervention; Behavioral: Control
Sponsors: University of Texas at Austin; The University of Texas at San Antonio; The University of Texas Health Science Center at San Antonio; University of Maryland, College Park
Recruiting
The Healthy Moms Study: Comparison of a Post-Partum Weight Loss Intervention Delivered Via Facebook or In-Person Groups

Conditions: Weight Loss; Diet Modification; Physical Activity
Intervention: Behavioral: Healthy Moms
Sponsors: University of Connecticut; University of Massachusetts, Worcester; Worcester Polytechnic Institute; National Heart, Lung, and Blood Institute (NHLBI)
Recruiting
A Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single and Multiple Doses of IONIS FXI-LRx in up to 84 Healthy Volunteers

Condition: Healthy Participants
Interventions: Drug: IONIS FXI-LRx; Drug: Placebo
Sponsor: Ionis Pharmaceuticals, Inc.
Completed
A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of MHAB5553A in Healthy Volunteers

Condition: Healthy Volunteer
Interventions: Drug: MHAB5553A; Drug: Matching placebo
Sponsor: Genentech, Inc.
Completed
Functional Brain Imaging in Healthy Volunteers to Study Cognitive Functions

Condition: Healthy Volunteers
Intervention:
Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)
Completed
A Study to Compare the Oral Bioavailability of Single Doses of Three Vapendavir Drug Formulations in Healthy Volunteers

Condition: Healthy
Interventions: Drug: vapendavir 132 mg capsule; Drug: vapendavir 264 mg tablet; Drug: vapendavir 24 mg/mL oral suspension
Sponsor: Aviragen Therapeutics
Completed
Pharmacokinetic, Safety, Tolerability and Immunogenicity Study of SB4 in Healthy Male Subjects

Condition: Healthy
Interventions: Biological: SB4; Biological: EU sourced Enbrel; Biological: US sourced Enbrel
Sponsor: Samsung Bioepis Co., Ltd.
Completed
Clinical Study to Evaluate the Pharmacokinetics, Safety, Tolerability and Pharmacodynamic Effects of a Single and Multiple Oral BAY1101042 Tablet Doses in Healthy Male Subjects

Condition: Healthy Volunteer
Interventions: Drug: BAY1101042; Drug: Placebo
Sponsor: Bayer
Completed
Comparative, Pharmacokinetic and Pharmacodynamic Study of Subcutaneous Injections of INTP5 of Intas Pharmaceuticals Ltd., India Against Neulasta of Amgen Inc., USA in Healthy, Adult Human Subjects.

Condition: Pharmacokinetic Bioequivalence Study in Human Healthy Volunteers
Interventions: Combination Product: INTP5; Combination Product: US Neulasta
Sponsors: Intas Pharmaceuticals, Ltd.; Lambda Therapeutic Research Ltd.
Completed
A Study of Tralokinumab When Delivered Subcutaneously at Different Flow Rates to Healthy Volunteers

Conditions: Asthma; Healthy Subjects or Volunteers
Intervention: Biological: Tralokinumab 300 mg
Sponsor: MedImmune LLC
Completed
Multiple Dose Ethnobridging PK Study in Healthy Subjects

Conditions: Inflammatory Bowel Diseases; IBD
Interventions: Drug: TD-1473 - Dose A; Drug: TD-1473 - Dose B; Drug: TD-1473 - Dose C; Drug: Placebo
Sponsor: Theravance Biopharma
Completed
A Study to Test the Safety, Pharmacokinetics, and Pharmacodynamics of Single Ascending Intravenous Doses of UCB0107 in Healthy Male Subjects

Condition: Healthy Male Volunteers
Interventions: Drug: UCB0107; Other: Placebo
Sponsor: UCB Biopharma S.P.R.L.
Completed
2-HOBA: Multiple Dosing Study in Healthy Humans

Condition: Healthy Volunteers
Interventions: Dietary Supplement: 2-HOBA; Dietary Supplement: Placebo
Sponsors: Metabolic Technologies Inc.; Vanderbilt University; National Institute on Aging (NIA)
Completed
This Study in Healthy Men Tests How Different Doses of BI 705564 Are Taken up in the Body and How Well They Are Tolerated. The Study Also Tests How BI 705564 Affects the Way the Body Breaks Down Midazolam

Condition: Healthy
Interventions: Drug: BI 705564; Drug: Placebo
Sponsor: Boehringer Ingelheim
Completed
The Microbiome of Sputum, Urine and Feces in Healthy Persons and Chronic Obstructive Pulmonary Disease (COPD) Patients

Conditions: Pulmonary Disease, Chronic Obstructive; Emphysema or COPD; Microbiota
Intervention: Diagnostic Test: obtain samples from sputum, feces and urine
Sponsor: Asan Medical Center
Recruiting
Study of Pharmacokinetics of a Single IV Dose of CB-238,618 in Subjects With Varying Degrees of Renal Impairment Compared to Healthy Subjects (MK-6183-001)

Conditions: Healthy Volunteers; Renal Impairment
Intervention: Drug: MK-6183
Sponsor: Cubist Pharmaceuticals LLC
Completed
Relative Bioavailability of Gantenerumab Produced by G4 Process Versus G3 Process Following Subcutaneous (SC) Injection in Healthy Participants

Condition: Healthy Participants
Intervention: Drug: Gantenerumab
Sponsor: Hoffmann-La Roche
Completed
A Single and Multiple Dose Study to Assess How the Drug Enters, Moves Through and Exits the Body, Safety and Tolerability of Safinamide in Healthy Adult Chinese Volunteers

Condition: Healthy
Interventions: Drug: Safinamide 50 mg; Drug: Safinamide 100mg
Sponsor: Zambon SpA
Not yet recruiting
Single-Ascending Dose Study of BIIB054 in Healthy Participants and Early Parkinson's Disease

Conditions: Parkinson's Disease; Healthy
Interventions: Drug: BIIB054; Drug: Placebo
Sponsor: Biogen
Completed
Randomized, Double-blind, Controlled Study to Evaluate the Effect of Concord Grape Extract on Vascular Function in Healthy Men and Women

Condition: Healthy Men and Women
Interventions: Dietary Supplement: Placebo; Dietary Supplement: Concord Grape extract 1; Dietary Supplement: Concord Grape extract 2
Sponsors: King's College London; Naturex-Dbs
Completed
A Pharmacokinetic Study Comparing MB02 And US And EU Avastin® In Healthy Male Volunteers

Condition: Healthy Volunteers
Interventions: Drug: MB02; Drug: US licenced Avastin®; Drug: EU approved Avastin®
Sponsor: mAbxience S.A
Completed
Effect of Food, Rabeprazole, Methotrexate and Formulation on the Pharmacokinetics (PK) of GDC-0853 and the Effect of GDC-0853 on the PK of Methotrexate in Healthy Subjects

Condition: Healthy Volunteer
Interventions: Drug: Folic Acid; Drug: GDC-0853; Drug: Methotrexate; Drug: Rabeprazole
Sponsor: Genentech, Inc.
Completed
Pharmacokinetics of Tranexamic Acid After Oral, Intramuscular or Intravenous Administration: a Prospective, Randomised, Cross-over Trial in Healthy Volunteers.

Condition: Healthy Volunteer Study
Interventions: Drug: Tranexamic Acid 1 gram intravenously; Drug: Tranexamic acid 2 grams oral solution; Drug: Tranexamic acid 1 gram intramuscular
Sponsor: London School of Hygiene and Tropical Medicine
Not yet recruiting
Study of the Effect of a 5-Day Regimen of Study Drug on Peripheral Stem Cell Mobilization in Healthy Participants

Condition: Healthy Participants
Intervention: Drug: Tbo-filgrastim
Sponsor: Teva Pharmaceutical Industries, Ltd.
Terminated
A 2 Part Study to Assess the Relative Bioavailability of Tablet Formulation Compared to Capsule Formulation and the Effect of Food and Taste Assessment on the Tablet Formulation in Healthy Participants

Condition: Healthy Volunteers
Interventions: Drug: RO7017773 Phase I Capsule; Drug: RO7017773 Phase II Tablet Unflavored; Drug: RO7017773 Phase II Tablet Sweetened/Flavored
Sponsor: Hoffmann-La Roche
Completed
A Study of LY2940680 in Healthy Participants

Condition: Healthy Volunteers
Intervention: Drug: [^14C]-LY2940680
Sponsor: Eli Lilly and Company
Completed
Evaluation of [123I]CLINDE and SPECT as a Marker of Inflammation in Subjects With PD or AD and in Healthy Subjects

Conditions: Parkinson Disease; Alzheimer Disease; Healthy Controls; Multiple Sclerosis
Intervention: Drug: [123I]CLINDE
Sponsor: Institute for Neurodegenerative Disorders
Terminated
A Study of the Safety, Tolerability, Pharmacokinetics and Pharmacodynamic Effects of Single and Multiple Ascending Doses of GDC-0334 and the Effect of Food on the Pharmacokinetics of GDC-0334 in Healthy Adult Participants

Condition: Healthy Volunteers
Interventions: Drug: GDC-0334; Drug: Placebo
Sponsor: Genentech, Inc.
Terminated
A Study to Assess Isavuconazole Following a Single Dose of Isavuconazonium Sulfate Intravenous Solution Via Nasogastric (NG) Tube Compared to a Single Dose of Oral Capsules Under Fasting Conditions in Healthy Participants

Condition: Healthy Subjects
Interventions: Drug: Isavuconazonium sulfate IV; Drug: Isavuconazonium sulfate capsules
Sponsor: Astellas Pharma Global Development, Inc.
Not yet recruiting
Study to Evaluate the Safety and Tolerability of Mucinex™(Guaifenesin) 600 mg Extended-Release Bi-Layer Tablets in the Treatment of Otherwise Healthy Patients With Symptoms of Cough, Thickened Mucus and Chest Congestion

Condition: Healthy Subjects
Intervention: Drug: Mucinex™ extended-release (SE)
Sponsor: Reckitt Benckiser LLC
Completed
A Study to Investigate the Effect of Formulation, Food, and Rabeprazole on the Pharmacokinetics (PK) of GDC-0853 in Healthy Participants

Condition: Healthy Volunteers
Interventions: Drug: GDC-0853; Drug: Rabeprazole
Sponsor: Genentech, Inc.
Completed
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7049665 in Healthy Volunteers

Condition: Healthy Volunteers
Interventions: Biological: RO7049665; Biological: Placebo
Sponsor: Hoffmann-La Roche
Completed
A Safety and Pharmacokinetic Study of AG-881 in Healthy Male Participants Following Administration of a Single Oral Dose of [14C] AG-881 and Concomitant Intravenous Microdose of [13C315N3] AG-881

Condition: Healthy Male Participants
Interventions: Drug: AG-881; Drug: [13C315N3]AG-881
Sponsor: Agios Pharmaceuticals, Inc.
Recruiting
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Ascending Single- and Multiple-Doses of TAK-020 in Healthy Volunteers

Condition: Healthy Volunteers
Interventions: Drug: TAK-020; Drug: TAK-020 Placebo
Sponsor: Takeda
Completed
A Study to Evaluate the Efficacy of the Investigational Products on Complete Spontaneous Bowel Movements in Participants Who Normally Have ≤ 3 Complete Spontaneous Bowel Movements Per Week But Are Otherwise Healthy

Conditions: Functional Constipation; Healthy
Interventions: Dietary Supplement: Actazin (green kiwi powder) High Dose; Dietary Supplement: Actazin (green kiwi powder) Low Dose; Dietary Supplement: Control Formula (Actazin green kiwi powder + PreticX prebiotic); Dietary Supplement: Livaux (gold kiwi powder) High Dose; Dietary Supplement: Livaux (gold kiwi powder) Low Dose; Dietary Supplement: Placebo (microcrystalline cellulose)
Sponsors: AIDP, Inc.; KGK Science Inc.
Recruiting
A Study to Determine the Safety, Tolerability, and Pharmacokinetics of GDC-0310 in Healthy Volunteers

Condition: Healthy Volunteer
Interventions: Drug: GDC-0310; Drug: Placebo
Sponsor: Genentech, Inc.
Completed
A Study to Evaluate the Pharmacokinetics (PK), Safety and Tolerability of TAK-788 Followed by Evaluation of the Effects of a Low-Fat Meal on TAK-788 PK and Evaluation of Relative Bioavailability of TAK-788 Capsules in Healthy Participants

Condition: Healthy Volunteers
Interventions: Drug: TAK-788; Drug: Placebo; Drug: Drug: TAK-788
Sponsor: Millennium Pharmaceuticals, Inc.
Completed
A Phase I Study in Healthy Volunteers

Condition: Pharmacokinetics and Safety in Healthy Volunteers
Interventions: Drug: 50 mg PTI-125; Drug: 100 mg PTI-125; Drug: 200 mg PTI-125
Sponsors: Pain Therapeutics; National Institutes of Health (NIH)
Completed
A Study of LY2886721 in Healthy Participants

Condition: Healthy Volunteers
Interventions: Drug: LY2886721; Drug: Placebo
Sponsor: Eli Lilly and Company
Completed
Nitric Oxide Lung Diffusing Capacity in Healthy, Non-smoking Adults

Condition: Healthy
Interventions: Device: Jaeger Masterscreen TM; Device: HypAir Medisoft
Sponsor: University of Zurich
Not yet recruiting
A Randomized, Two-way, Crossover Study to Estimate the Relative Bioavailability of a Controlled-release Formulation of Oxycodone (40 mg) With Sequestered Naltrexone Compared With Immediate-release Oxycodone Tablets (20 mg) in Healthy Volunteers

Condition: Healthy
Interventions: Drug: Oxycodone controlled-release test formulation; Drug: Immediate-release reference drug
Sponsor: Pfizer
Completed
A 5-Part Study In Healthy Volunteers To Evaluate Safety, Tolerability and Uptake Of MEDI7219 in the Body When Given as Single and Multiple Doses

Condition: Healthy Volunteers
Interventions: Drug: MEDI7219; Drug: Placebo; Drug: Formulation without Active Drug
Sponsor: MedImmune LLC
Recruiting
Safety, Tolerability and Immunogenicity of INO-4500 in Healthy Volunteers

Condition: Lassa Fever
Interventions: Drug: INO-4500; Drug: Placebo; Device: CELLECTRA® 2000
Sponsors: Inovio Pharmaceuticals; Coalition for Epidemic Preparedness Innovations (CEPI)
Recruiting
Technical Development of Clinical Laboratory Studies

Condition: Healthy Volunteers
Intervention:
Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)
Not yet recruiting
Study To Evaluate Safety And Tolerability Of Single And Multiple Ascending Doses Of PF- 06260414 In Healthy Western And Japanese Male Subjects

Condition: Healthy
Interventions: Drug: PF-06260414; Drug: Placebo
Sponsor: Pfizer
Completed
A Pilot Study of Rapid Haplotyping Procedure for Personalized Dosing of Dichloroacetate (DCA) in Healthy Volunteers

Condition: Healthy
Interventions: Drug: Dichloroacetate (DCA); Other: GSTZ1 haplotyping
Sponsors: University of Florida; Medosome Biotec LLC; Food and Drug Administration (FDA)
Completed
Kinetics of Blood Platelets Transfused to Healthy Subjects

Condition: Fetal and Neonatal Alloimmune Thrombocytopenia
Intervention: Other: Platelet transfusion
Sponsors: Prophylix Pharma AS; Larix A/S; Fraunhofer Institute for Molecular Biology and Applied Ecology; German Red Cross; Bioscientia Central Laboratory
Completed
Environmental Influences on Early Childhood Obesity

Condition: Childhood Obesity
Interventions: Behavioral: Healthy Homes; Other: Usual Care
Sponsor: University of Colorado, Denver
Active, not recruiting
This Study in Healthy Volunteers Determines the Amount of BI 730460 in the Blood When Taken as Tablet. It Looks at How Different Doses of BI 730460 Are Taken up in the Body and How Well They Are Tolerated. The Study Also Tests How Food Influences the Amount of BI 730460 in the Blood.

Condition: Healthy
Interventions: Drug: BI 730460; Drug: Placebo
Sponsor: Boehringer Ingelheim
Completed
A Study of LY2484595 in Healthy Subjects

Condition: Healthy Volunteers
Interventions: Drug: LY2484595 Reference Formulation (RF); Drug: LY2484595 spray-dried solid dispersion-propyl gallate (SDSD-PG)
Sponsor: Eli Lilly and Company
Completed
A Technical Innovation of Prismatic Adaptation Test in Healthy Subject, in Favour of Autonomy and Independence in Daily Life Following a Brain Injury

Condition: Healthy Volunteers
Interventions: Behavioral: Prismatic goggles; Behavioral: Virtual reality device
Sponsor: Hospices Civils de Lyon
Not yet recruiting
Effects of CS-8080 in Healthy Volunteers

Condition: Healthy
Interventions: Drug: CS8080; Drug: Placebo
Sponsor: Daiichi Sankyo, Inc.
Completed
Comparative Safety, Tolerability, Pharmacokinetic Study of AVT02 (100MG/ML) and Humira (100MG/ML) in Healthy Volunteers

Condition: Healthy Volunteers
Interventions: Drug: Adalimumab 100 MG/ML [Humira]; Drug: AVT02 100MG/ML
Sponsor: Alvotech Swiss AG
Completed
Investigating the Efficacy of Rest-ZZZ Formula in Healthy Participants With Difficulty Falling Asleep or Staying a Sleep

Conditions: Sleep; Healthy
Interventions: Dietary Supplement: Rest-ZZZ; Drug: Active Comparator - Diphenhydramine HCl; Other: Placebo
Sponsors: LifeSeasons Inc.; KGK Science Inc.
Recruiting
A Study of Insulin Peglispro in Healthy Male Japanese Participants

Condition: Healthy Volunteers
Intervention: Drug: Insulin Peglispro
Sponsor: Eli Lilly and Company
Completed
Dose-ranging Study: Safety, Tolerability and Immunogenicity of INO-4500 in Healthy Volunteers in Ghana

Condition: Lassa Fever
Interventions: Drug: INO-4500; Device: CELLECTRA™ 2000; Drug: Placebo
Sponsor: Inovio Pharmaceuticals
Not yet recruiting
A Study of Evacetrapib With Selected Statins in Healthy Chinese Participants

Condition: Healthy Volunteers
Interventions: Drug: Evacetrapib; Drug: Simvastatin; Drug: Atorvastatin
Sponsor: Eli Lilly and Company
Completed
Pilot Study of ORG 25935 Modulation of Ketamine-induced Behavioral and Cognitive Effects in Healthy Male Subjects

Condition: Healthy
Interventions: Drug: Ketamine and Org 25935; Drug: Placebo and Ketamine
Sponsors: Yale University; Organon
Active, not recruiting
A First in Human Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of a Intravenous (IV) Dose of GSK2831781 in Healthy Volunteers and Patients With Plaque Psoriasis

Condition: Psoriasis
Interventions: Biological: GSK2831781; Biological: Placebo
Sponsors: GlaxoSmithKline; Parexel
Completed
A Study to Evaluate the Pharmacokinetics, Safety and Tolerability of PF-06651600 in Subjects With Hepatic Impairment and Healthy Volunteers

Conditions: Hepatic Impairment; Healthy Participants
Intervention: Drug: PF-06651600 30 mg
Sponsor: Pfizer
Recruiting
A Study to Assess the Impact of Speed and Site of Subcutaneous Injection on Pain, Tolerability, Safety, and Pharmacokinetics of Gantenerumab in Healthy Participants

Condition: Healthy Volunteer
Interventions: Drug: Gantenerumab; Drug: Placebo
Sponsor: Hoffmann-La Roche
Completed
Study to Assess the Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Effects of a Single Dose of REGN5713-5714-5715 in Healthy Adult Participants

Conditions: Healthy Volunteers; Birch Pollen Allergy
Interventions: Drug: REGN5713-5714-5715; Drug: Matching placebo
Sponsor: Regeneron Pharmaceuticals
Recruiting
Investigating Transcranial Direct Current Stimulation (tDCS) in Accelerating Learning in a Healthy Older Population

Condition: Associative Memory in Healthy Subjects
Interventions: Device: Active tDCS; Device: Sham tDCS
Sponsor: The University of Texas at Dallas
Active, not recruiting
A Pharmacokinetic (PK) Study of Three Types of E0302 Sustained Release (SR) Tablets Compared With E0302 Immediate Release (IR) Tablet Under Fed Conditions in Healthy Participants

Condition: Healthy Subjects
Interventions: Drug: E0302 SR1; Drug: E0302 SR3; Drug: E0302 SR2; Drug: E0302 IR
Sponsor: Eisai Co., Ltd.
Completed
A Multiple Dose Study of LY3023703 in Healthy Participants

Condition: Healthy Volunteers
Interventions: Drug: Placebo; Drug: LY3023703; Drug: Celecoxib
Sponsor: Eli Lilly and Company
Completed
A Study of Evacetrapib in Healthy Female Participants

Condition: Healthy Volunteers
Interventions: Drug: Ortho-Cyclen; Drug: Evacetrapib
Sponsor: Eli Lilly and Company
Completed
Study of Food on Evacetrapib (LY2484595) in Healthy Participants

Condition: Healthy Volunteers
Interventions: Drug: Evacetrapib; Other: High-fat Meal
Sponsor: Eli Lilly and Company
Completed
A Study to Evaluate the Absorption, Distribution, Metabolism, Excretion and Absolute Bioavailability of AG-348 in Healthy Male Participants Following Administration of a Single Oral Dose of [14C]AG-348 and Concomitant Single Intravenous Microdose of [13C6]AG-348

Condition: Healthy Volunteers
Interventions: Drug: AG-348; Drug: [13C6]AG-348
Sponsor: Agios Pharmaceuticals, Inc.
Completed
A Single-Dose Study to Investigate the Safety, Tolerability, and Pharmacokinetics (PK) of Gantenerumab Following Subcutaneous (SC) Administration in Healthy Volunteers

Condition: Healthy Volunteer
Interventions: Drug: Gantenerumab; Drug: Placebo
Sponsor: Hoffmann-La Roche
Completed
Safety of a Quadrivalent Meningococcal Conjugate Vaccine Administered Concomitantly With Routine Pediatric Vaccines in Healthy Infants and Toddlers

Condition: Healthy Volunteers (Meningococcal Infection)
Interventions: Biological: Meningococcal polysaccharide (serogroups A,C,Y and W) tetanus toxoid conjugate vaccine (MenACYW conjugate vaccine); Biological: Meningococcal (Groups A, C, Y and W 135) Oligosaccharide Diphtheria CRM197 Conjugate Vaccine (MENVEO®); Biological: Diphtheria, Tetanus, Acellular Pertussis, Poliovirus and Haemophilus b Vaccine; Biological: Pneumococcal 13-valent Conjugate Vaccine; Biological: Rotavirus Vaccine; Biological: Hepatitis B Vaccine; Biological: Measles, Mumps, and Rubella Virus Vaccine; Biological: Varicella Virus Vaccine
Sponsor: Sanofi Pasteur, a Sanofi Company
Recruiting
Disposition of Carbon-14-Labeled LY2886721 ([^14C]-LY2886721) Following Oral Administration in Healthy Human Participants

Condition: Healthy Volunteers
Intervention: Drug: LY2886721
Sponsor: Eli Lilly and Company
Completed
Phase 1 TAK-906 Single and Multiple Ascending Dose Study in Japanese Healthy Male Participants

Condition: Japanese Healthy Adult Male Participants
Interventions: Drug: TAK-906; Drug: TAK-906 Placebo
Sponsor: Takeda
Completed
A Three-part Study to Determine the Safety, Tolerability and Pharmacokinetics of GSK1322322 in Healthy Volunteers and Healthy Male Japanese Subjects

Condition: Infections, Bacterial
Interventions: Drug: GSK1322322 Initial fit for purpose tablets; Drug: GSK1322322 over granulated tablets; Drug: GSK1322322 intended commercial tablets; Drug: Placebo tablets; Drug: 13C-GSK1322322 stable isotope powder; Drug: GSK1322322 for injection; Drug: Placebo injection
Sponsor: GlaxoSmithKline
Terminated
Evaluation of Lung Volume Under Nasal High Flow With a Time of Flight Camera

Conditions: High Flow Nasal; Time of Flight Camera; Lung Volume; Healthy Volunteers
Intervention: Other: Ventilation of healthy volunteers
Sponsor: University Hospital, Brest
Not yet recruiting
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of TAK-925 in Healthy Volunteers and Patients With Narcolepsy

Conditions: Healthy Participants; Narcolepsy
Interventions: Drug: TAK-925; Drug: Placebo
Sponsor: Takeda
Recruiting
Bioavailability, Pharmacokinetics and Safety Evaluation of Phencynonate Hydrochloride in Healthy Volunteers

Condition: Healthy
Intervention: Drug: Phencynonate hydrochloride
Sponsor: PhytoHealth Corporation
Completed
Evaluate the Safety, Tolerability and PK of Different Formulations of Orally Administered Solabegron in Healthy Male Subjects

Condition: Healthy Subjects, Overactive Bladder
Interventions: Drug: Formulation 1 solabegron; Drug: Formulation 2 solabegron
Sponsor: Velicept Therapeutics, Inc.
Completed
Event-Related Potential (ERP) Biomarkers in Subjects With Schizophrenia and Healthy Volunteer Subjects

Condition: Schizophrenia
Intervention: Device: Event-Related Potentials (ERP) and Electroencephalogram (EEG) testing with the COGNISION® System
Sponsors: ERP Biomarker Qualification Consortium; COGNISION; Cadent Therapeutics; Alkermes, Inc.; Anavex Life Sciences Corp.; Merck Sharp & Dohme Corp.; Takeda; Sage Therapeutics; H. Lundbeck A/S
Not yet recruiting
Pharmacokinetics and Metabolism of (14C)-Labelled PXL770

Condition: Healthy
Intervention: Drug: 14C labeled PXL770
Sponsor: Poxel SA
Completed
A Study of Orally Administered JNJ-440 to Evaluate the Safety, Tolerability, and Pharmacokinetics After Single Ascending Doses Including Food Effect Evaluation; After Multi-Day Dosing in Healthy Participants; and After Multiple (Ascending) Doses in Participants With Chronic Hepatitis B

Condition: Chronic Hepatitis B
Interventions: Drug: JNJ-440; Drug: Placebo
Sponsor: Alios Biopharma Inc.
Recruiting
The Influence of BMI on Core Stability in Healthy Adults

Conditions: Overweight and Obesity; Balance; Distorted
Intervention: Diagnostic Test: Core Stability Assessment
Sponsors: Wafaa Mahmoud Amin; Cairo University
Completed
A Study to Evaluate Bioavailability and Food Effect of Selumetinib (AZD6244) in Healthy Male Participants

Conditions: Neurofibromatosis Type 1 (NF1)-Related Plexiform Neurofibromas (PNs); Healthy Participants
Interventions: Drug: Treatment A; Drug: Treatment B; Drug: Treatment C; Drug: Treatment D; Drug: Acetaminophen
Sponsor: AstraZeneca
Completed
TOP-mums, for a Healthy Start

Conditions: Overweight; Obesity; Pregnancy Complications
Intervention: Behavioral: Lifestyle intervention
Sponsor: Maastricht University Medical Center
Recruiting
Effects of the NO-synthase Inhibitor VAS203 on Renal Function in Healthy Volunteers

Condition: Renal Function Impairment in Healthy Volunteers
Interventions: Drug: VAS203; Drug: Saline
Sponsors: Vasopharm GmbH; Winicker Norimed GmbH
Completed
A Study of LY2605541 in Healthy Participants

Condition: Healthy Volunteers
Intervention: Drug: LY2605541
Sponsor: Eli Lilly and Company
Completed
Motivational Interviewing for Getting Healthy TodaY Study

Conditions: Pregnancy Related; Diet Modification
Interventions: Behavioral: CAMI-TPP; Behavioral: CAMI-Fitness
Sponsors: Columbia University; The Office of Adolescent Health, HHS; Centers for Disease Control and Prevention
Not yet recruiting
A Study of LY3031207 in Healthy Subjects

Condition: Healthy Volunteers
Interventions: Drug: LY3031207; Drug: Placebo; Drug: Celecoxib
Sponsor: Eli Lilly and Company
Completed
A Study of Carbon-14-Labeled LY2835219 ([^14C]-LY2835219) in Healthy Participants

Condition: Healthy Volunteers
Intervention: Drug: [^14C]-LY2835219
Sponsor: Eli Lilly and Company
Completed
Single Rising Dose Study of MK-8723 in Healthy Participants and Participants With Immune Thrombocytopenia Purpura (MK-8723-001)

Condition: Immune Thrombocytopenia Purpura
Interventions: Drug: MK-8723; Drug: Matching Placebo
Sponsor: Merck Sharp & Dohme Corp.
Completed
A Phase I Study of PP-001 Eye Drops in Healthy Adult Volunteers

Condition: Keratoconjunctivitis
Interventions: Drug: PP-001; Other: Placebo
Sponsor: Panoptes Pharma GmbH
Active, not recruiting
A Multiple-dose Study of LY3031207 in Healthy Participants

Condition: Healthy Volunteers
Interventions: Drug: Placebo; Drug: LY3031207; Drug: Celecoxib; Drug: Simvastatin
Sponsor: Eli Lilly and Company
Terminated
Safety, Tolerability, PK and PD of SAD or MAD of APX-115 in Healthy Male Volunteers

Conditions: Healthy; Safety
Interventions: Drug: SAD: APX-115; Drug: SAD: Placebo; Drug: MAD: APX-115; Drug: MAD: Placebo; Other: Food effect: fasted and fed; Other: Metabolic probe with or without APX-115
Sponsor: Aptabio Therapeutics, Inc.
Completed
Comparative Immunogenicity Study of Multiple Doses of Proposed Pegfilgrastim Biosimilar, INTP5 of Intas Pharmaceuticals Ltd., India Against Neulasta of Amgen Inc., USA in Healthy, Adult Human Subjects.

Conditions: Immunogenicity; Healthy Volunteers
Interventions: Combination Product: INTP5; Combination Product: US Neulasta
Sponsors: Intas Pharmaceuticals, Ltd.; Lambda Therapeutic Research Ltd.
Completed
Subcutaneous Elafin in Healthy Subjects

Condition: Pulmonary Arterial Hypertension
Interventions: Drug: Elafin; Drug: Placebo
Sponsors: Roham T. Zamanian; Duke University; SRI International
Recruiting
The Effect of Experimental Neck Pain in Healthy Participants

Conditions: Healthy; Neck Pain
Interventions: Other: Injection of Isotonic saline; Other: Injection of NGF
Sponsor: Aalborg University
Recruiting
Local Anesthetic Response in Ehlers-Danlos Syndrome (EDS) and Healthy Volunteers

Conditions: Ehlers-Danlos Syndrome; Anesthesia, Local
Interventions: Drug: 0.9% Sodium Chloride Injection; Drug: Lidocaine Injection 2%; Drug: Bupivacaine Injection 0.5%
Sponsors: Vanderbilt University Medical Center; University of Calgary
Enrolling by invitation
Volume Kinetics for Hyperoncotic Albumin in Burn Patients as Well as for Healthy Subjects

Condition: Burns
Intervention: Drug: Albumins
Sponsor: University Hospital, Linkoeping
Completed
Bisnorcymserine in Healthy Adult Volunteers

Conditions: Alzheimer's Disease; Healthy Volunteers
Interventions: Drug: BNC; Other: Placebo
Sponsor: National Institute on Aging (NIA)
Completed
Study C3S : Comparison Among Healthy Subject

Condition: Healthy Volunteers
Intervention: Device: Comparative standard echocardiography between two devices : Vivid 9 General Electric and Epiq 7 Philips
Sponsor: University Hospital, Clermont-Ferrand
Recruiting
Relatively Healthy Male Veterans Observed Over Time to See What Types of Diseases Develop

Condition: Healthy
Intervention:
Sponsor: VA Office of Research and Development
Active, not recruiting
A Study of Orally Administered JNJ-56136379 to Evaluate Safety, Tolerability and Pharmacokinetics After Single Ascending Doses and One Multiple Dose Regimen in Healthy Participants (Part I), and After Multiple Dose Regimens in Participants With Chronic Hepatitis B (Part II)

Conditions: Healthy; Hepatitis, Chronic
Interventions: Drug: JNJ-56136379; Drug: Placebo
Sponsor: Janssen Sciences Ireland UC
Completed
A Study Comparing Once-Daily vs. Twice-Daily Dosing of X4P-001 in Healthy Volunteers

Condition: Healthy
Intervention: Drug: X4P-001
Sponsors: X4 Pharmaceuticals; Covance
Terminated
Impact of Once-Weekly Rifapentine and Isoniazid on the Steady State Pharmacokinetics of Dolutegravir and Darunavir Boosted With Cobicistat in Healthy Volunteers

Condition: Healthy Volunteers
Interventions: Drug: rifapentene (RPT); Drug: darunavir/cobicistat (DRV/c); Drug: Isoniazid (INH); Dietary Supplement: Pyridoxine
Sponsor: National Institutes of Health Clinical Center (CC)
Recruiting
A Study to Evaluate Pharmacokinetic (PK) and Safety of GSK1265744 in Subjects With Hepatic Impairment and Control Healthy Volunteers

Condition: HIV Infections
Intervention: Drug: GSK1265744 30mg
Sponsors: ViiV Healthcare; GlaxoSmithKline
Completed
VRC 208: Dose, Safety and Immunogenicity of a Recombinant Modified Vaccinia Virus Ankara Ebola Vaccine, VRC-EBOMVA079-00-VP (MVA-EbolaZ), Administered Alone or as a Boost to cAd3-Ebola Vaccines in Healthy Adults

Condition: Healthy Adult Immune Responses to Vaccine
Interventions: Biological: VRC-EBOMVA079-00-VP (MVA-EbolaZ); Biological: VRC-EBOADC069-00-VP (cAd3-EBO)
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Completed
A Study of LY2886721 in Healthy Participants and Participants Diagnosed With Alzheimer's Disease

Conditions: Alzheimer Disease; Healthy Volunteers
Interventions: Drug: LY2886721; Drug: Placebo
Sponsor: Eli Lilly and Company
Completed
A Cross-Cultural Assessment of the Motivations of Healthy Participants in Phase I Research

Condition: Healthy Volunteer
Intervention:
Sponsor: National Institutes of Health Clinical Center (CC)
Completed
Study of the Choroidal and Retinal Thickness in Relation to Axial Length.

Condition: Healthy
Interventions: Device: AL measurement; Device: OCT
Sponsor: Semmelweis University
Completed
A Study of Safety, Tolerability, and Pharmacokinetics of Multiple-Ascending Doses of PHP-303 in Otherwise Healthy Overweight or Obese Subjects

Condition: Otherwise Healthy Overweight or Obese
Interventions: Drug: PHP-303; Other: Placebo
Sponsor: pH Pharma
Recruiting
Single Dose Study in Healthy Participants to Investigate the Safety and Absorption of LY2584702

Condition: Healthy Participants
Interventions: Drug: LY2584702 Reference Formulation; Drug: LY2584702 Test Formulation; Drug: Placebo
Sponsor: Eli Lilly and Company
Completed
Study Designed to Assess the Safety, Tolerability and PK of PTI-808 in Healthy Volunteers and in Adults With Cystic Fibrosis

Conditions: Healthy Volunteer - Complete; Cystic Fibrosis
Interventions: Drug: PTI-808; Drug: Placebo; Drug: PTI-428; Drug: PTI-801
Sponsor: Proteostasis Therapeutics, Inc.
Recruiting
A Phase I SAD and MAD Clinical Trial of CNM-Au8 in Healthy Male and Female Volunteers

Condition: Healthy Volunteers - Male and Female
Interventions: Other: CNM-Au8; Other: Placebo
Sponsor: Clene Nanomedicine
Completed
Phosphorus Absorption in Healthy Adults and in Patients With Moderate Chronic Kidney Disease

Condition: Chronic Kidney Disease Mineral and Bone Disorder
Intervention: Other: Phosphorus Absorption Test
Sponsor: Purdue University
Active, not recruiting
A Multiple Dose Study of BAY1834845 in Healthy Male Subjects and in Patients With Rheumatoid Arthritis (RA) or Psoriasis

Condition: Healthy Volunteers
Interventions: Drug: BAY1834845; Other: Matching Placebo; Drug: Midazolam
Sponsor: Bayer
Recruiting
Study of Ascending Single Oral Dose of GT-002 in Healthy Volunteers

Condition: Safety and Tolerability
Interventions: Drug: GT-002; Drug: Placebo oral capsule
Sponsors: Gabather AB; Smerud Medical Research International AS
Recruiting
6x3 Crossover, Bioavailability, Safety and Tolerability Among Different Eutropin Formulations in Healthy Volunteers

Condition: Bioavailability, Safety and Tolerability Among Different Eutropin Formulations in Healthy Volunteers
Intervention: Drug: Somatropin
Sponsor: LG Chem
Not yet recruiting
A Phase 1 Study to Assess the Safety of NLY01 in Healthy Subjects

Condition: Safety and Tolerability in Healthy Volunteers
Intervention: Drug: NLY01
Sponsor: Neuraly, Inc.
Recruiting
Determination of Normal Reference Values of CRP, Procalcitonin, and Lactate Levels for the Nanōmix eLab® System

Condition: Healthy
Intervention:
Sponsor: Nanomix
Completed
A Pharmacokinetic Study of the Effect of Itraconazole Exposure to Orvepitant in Healthy Volunteers

Condition: Pharmacokinetic Study in Healthy Male Volunteers
Interventions: Drug: Orvepitant; Drug: Itraconazole
Sponsor: Nerre Therapeutics Ltd.
Completed
Effects of Low-level Laser Therapy in the Fatigue Muscle of Healthy Individual and Spastic Individuals

Conditions: Fatigue; Stroke Sequelae
Intervention: Other: Low-level laser therapy
Sponsor: Universidade do Vale do Paraíba
Recruiting
A Study of LY2484595 on Pharmacokinetics in Healthy Participants

Condition: Healthy Participants
Interventions: Drug: LY2484595; Drug: Placebo; Drug: Ketoconazole
Sponsor: Eli Lilly and Company
Completed
The Seattle Social Development Project: An Implementation of the Raising Healthy Children Intervention

Conditions: Adolescent Health; Adolescent Problem Behavior
Intervention: Behavioral: The Raising Healthy Children intervention, including teacher training, child skill development, and parent training
Sponsors: University of Washington; National Institute on Drug Abuse (NIDA)
Completed
Modulating Pain Using Transcranial Alternating Stimulation (tACS) in Healthy Human Subjects

Condition: Experimental Pain in Healthy Human Subjects
Interventions: Device: 10 Hz tACS of the bilateral somatosensory cortex; Device: 10 Hz tACS of the prefrontal cortex; Device: 80 Hz tACS of the bilateral somatosensory cortex; Device: 80 Hz tACS of the prefrontal cortex; Device: Sham stimulation of the bilateral somatosensory cortex; Device: Sham stimulation of the prefrontal cortex
Sponsors: Technische Universität München; German Research Foundation
Recruiting
Safety and Pharmacokinetics of a Human Monoclonal Antibody, VRC-EBOMAB092-00-AB (MAb114), Administered Intravenously to Healthy Adults

Condition: Healthy Adult Immune Responses to Vaccine
Intervention: Biological: VRC-EBOMAB092-00-AB (MAb114)
Sponsors: National Institute of Allergy and Infectious Diseases (NIAID); The Emmes Company, LLC
Completed
Studying the Starvation Effect on Androgen Metabolism in 20 Healthy Young Women and Comparison to Women With PCOS.

Condition: PCOS Disease
Intervention: Other: Androgen metabolism after starvation
Sponsor: University Hospital Inselspital, Berne
Completed
Study of the Impact of the Regular Consumption of Polyphenol-rich Grape Juice on the Biological Parameters of Oxidative Stress and on Endothelial Function in Healthy Subjects

Condition: Healthy Subjects
Interventions: Other: Grape juice R@isol; Other: Commercially-available grape juice
Sponsor: Centre Hospitalier Universitaire Dijon
Completed
A First in Human Study in Healthy Volunteers and in Participants With Frontotemporal Dementia With Granulin Mutation

Conditions: Healthy; Frontotemporal Dementia
Interventions: Biological: AL001; Other: Placebo
Sponsor: Alector Inc.
Recruiting
Pharmacokinetics, Dialysability and Safety of P03277 in Healthy Volunteers and in Patients With Impaired Renal Function

Conditions: Renal Insufficiency; Healthy Volunteers
Intervention: Drug: P03277
Sponsor: Guerbet
Active, not recruiting
Comparison of Gastrointestinal Motility in Healthy Children and Children With Constipation

Conditions: Constipation; Childhood Acute Lymphoblastic Leukemia; Neurofibromatosis 1; Chronic Constipation With Overflow
Intervention: Diagnostic Test: 3D-Transit
Sponsor: University of Aarhus
Recruiting
Effect of Hypoxia on Cognitive Assessment and Cerebral Activity in Healthy Volunteers

Conditions: Alteration of Cognitive Function; Hypoxia
Intervention: Other: 2-hour period of hypoxia
Sponsor: University Hospital, Lille
Recruiting
Evaluation of the Ocular Safety of Calcium Formate in Normal, Healthy Female Subjects

Condition: Healthy
Intervention: Drug: calcium formate
Sponsors: University of Wisconsin, Madison; Nephro-Tech 1, LLC
Completed
First In Human Study To Evaluate The Safety, Tolerability, Pharmacokinetics And Pharmacodynamics Of PF-04427429 Administered Intravenously To Healthy Adult Volunteers

Condition: Healthy Volunteers
Intervention: Drug: PF-04427429
Sponsor: Pfizer
Completed
Immunogenicity and Safety Study of a Quadrivalent Meningococcal Conjugate Vaccine Administered Concomitantly With Routine Pediatric Vaccines in Healthy Infants and Toddlers

Condition: Healthy Volunteers (Meningococcal Infection)
Interventions: Biological: Meningococcal Polysaccharide (Serogroups A,C,Y and W) Tetanus Toxoid Conjugate vaccine MenACYW conjugate vaccine; Biological: Meningococcal (Groups A, C, Y and W 135) Oligosaccharide Diphtheria CRM197 Conjugate Vaccine; Biological: Meningococcal Polysaccharide (serogroups A,C,Y and W-135) Diphtheria Toxoid Conjugate Vaccine; Biological: Diphtheria and Tetanus Toxoids and Acellular Pertussis, inactivated Poliovirus and Haemophilus b Conjugate Vaccine; Biological: Diphtheria and Tetanus Toxoids and Acellular Pertussis, Hepatitis B and Inactivated Poliovirus Vaccine; Biological: Haemophilus b Conjugate Vaccine; Biological: Pneumococcal 13-valent Conjugate Vaccine; Biological: Rotavirus Vaccine, Live, Oral, Pentavalent; Biological: Hepatitis B Vaccine; Biological: Measles, Mumps, and Rubella Virus Vaccine Live; Biological: Varicella Virus Vaccine Live
Sponsor: Sanofi Pasteur, a Sanofi Company
Recruiting
Laboratory Testing for Tie-2 Expressing Monocytes (TEMs) in Blood

Conditions: Advanced Cancer; Healthy
Intervention:
Sponsor: University Health Network, Toronto
Completed
Nalmefene, Baclofen and Impulsivity in Subjects With Alcohol Use Disorder and Healthy Control Subjects

Condition: Alcohol Use Disorder
Interventions: Drug: Nalmefene; Drug: Baclofen; Drug: Placebo Oral Capsule
Sponsor: Prof. Daniele Zullino
Recruiting
Effect of Ivermectin Metabolites on Mosquito Survival

Condition: Healthy
Intervention: Drug: Ivermectin
Sponsor: University of Oxford
Not yet recruiting
[18F]DASA-23 and PET Scan in Evaluating Pyruvate Kinase M2 Expression in Patients With Intracranial Tumors or Recurrent Glioblastoma and Healthy Volunteers

Conditions: Healthy Subject; Intracranial Neoplasm; Recurrent Glioblastoma
Interventions: Drug: Fluorine F 18 DASA-23; Procedure: Positron Emission Tomography
Sponsor: Sanjiv Sam Gambhir
Recruiting
A Bioequivalence Study Testing Two Formulations of Sotagliflozin in Healthy Male and Female Subjects Under Fasted Conditions

Conditions: Type 2 Diabetes Mellitus; Healthy Subjects
Intervention: Drug: sotagliflozin (SAR439954)
Sponsor: Sanofi
Completed
A Smartphone Intervention for WIC Mothers to Improve Nutrition and Weight Gain During Pregnancy

Condition: Weight Gain During Pregnancy
Intervention: Behavioral: Healthy Beginnings
Sponsors: Pennington Biomedical Research Center; Louisiana Department of Health
Recruiting
Visual Field Defect Estimation Using Sequentially Optimized Reconstruction Strategy on Healthy and Glaucoma Subjects

Condition: Glaucoma, Open-Angle
Intervention: Diagnostic Test: Visual field testing
Sponsors: University Hospital Inselspital, Berne; University of Bern
Active, not recruiting
A Study in Healthy Volunteers and Patients With Chronic Hepatitis B

Conditions: Hepatitis B; Infectious Disease; Liver Diseases
Interventions: Drug: CRV431; Drug: Placebo; Drug: TDF
Sponsor: ContraVir Pharmaceuticals, Inc.
Active, not recruiting
Study of TAK-071 in Healthy Participants and Participants With Mild Cognitive Impairment/Mild Alzheimer Disease and Relative Bioavailability (BA) and Food Effect of TAK-071 in Healthy Participants

Conditions: Alzheimer Disease; Healthy Volunteers
Interventions: Drug: TAK-071; Drug: Donepezil; Drug: TAK-071 Placebo; Drug: Donepezil Placebo
Sponsor: Takeda
Terminated
Study of the Retinal Vascularization by Laser Doppler Velocimetry Coupled With an Adaptive Optics Camera ( AO-LDV)

Conditions: Glaucoma; Retinal Vein Occlusion
Intervention: Procedure: Laser Doppler Velocimetry + Optic Adaptative Camera
Sponsor: University Hospital, Grenoble
Recruiting
Polyunsaturated Fatty Acids Supplementation and Blood Metabolome

Condition: Healthy
Intervention: Other: The high PUFA diet group
Sponsor: Poznan University of Life Sciences
Recruiting
Motor Evoked Potentials With Modified Facilitation Technique

Condition: Multiple Sclerosis
Interventions: Diagnostic Test: MEP using standard facilitation technique; Diagnostic Test: MEP using modified facilitation technique
Sponsor: University Hospital, Basel, Switzerland
Recruiting
Pharmacokinetics, Safety and Tolerability of Treprostinil Inhalation Powder in Healthy Normal Volunteers

Condition: Pulmonary Arterial Hypertension
Intervention: Drug: Treprostinil Inhalation Powder
Sponsor: Mannkind Corporation
Completed
A Novel Smartphone Application for "Smart" Trials

Condition: Healthy
Intervention: Device: Mobile Health App
Sponsors: Universidade Federal de Sao Carlos; Tufts Medical Center
Recruiting
This Study Tests How Healthy Men Tolerate Different Doses of BI 730357 and How the Metabolism of Midazolam is Affected by BI 730357

Conditions: Healthy; Psoriasis
Interventions: Drug: BI 730357; Drug: Placebo; Drug: Midazolam
Sponsor: Boehringer Ingelheim
Completed
Differential Metabolic Signature of Stroke Patients Undergoing Thrombolysis

Condition: Stroke, Ischemic
Intervention:
Sponsor: Cambridge University Hospitals NHS Foundation Trust
Recruiting
Growth of Healthy Term Infants Fed a Partially Hydrolyzed Follow-up Formula

Condition: Growth
Intervention: Other: Formula feeding regimen
Sponsors: Nestlé; Biofortis Mérieux NutriSciences
Active, not recruiting
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of EYP001a in Healthy Volunteers and Nonalcoholic Steatohepatitis Patients

Conditions: NASH - Nonalcoholic Steatohepatitis; Healthy
Intervention: Drug: EYP001a
Sponsor: Enyo Pharma
Recruiting
Safety and Immunogenicity of a Quadrivalent Meningococcal Conjugate Vaccine When Administered Concomitantly With Routine Pediatric Vaccines in Healthy Infants and Toddlers in the Philippines, the Russian Federation, and Mexico

Condition: Healthy Volunteers (Meningococcal Infection)
Interventions: Biological: Meningococcal Polysaccharide (Serogroups A, C, Y, and W) Tetanus Toxoid Conjugate Vaccine MenACYW conjugate vaccine; Biological: Meningococcal (Groups A, C, Y and W 135) Oligosaccharide Diphtheria CRM197 Conjugate Vaccine; Biological: Measles, Mumps, and Rubella Virus Vaccine Live; Biological: Varicella Virus Vaccine; Biological: Pneumococcal 13-valent Conjugate Vaccine; Biological: Diphtheria, tetanus, pertussis (acellular component), hepatitis B, poliomyelitis (inactivated), and Haemophilus influenzae type b conjugate vaccine; Biological: Diphtheria, Tetanus, Pertussis (Acellular, Component) Poliomyelitis (inactivated) Vaccine, and Haemophilus influenza type b Conjugate Vaccine; Biological: Hepatitis B Vaccine; Biological: Rotavirus Vaccine, Live, Pentavalent; Biological: Japanese encephalitis vaccine (live, attenuated)
Sponsor: Sanofi Pasteur, a Sanofi Company
Recruiting
A Study of ABI-H2158 in Healthy Volunteers and Patients With Chronic Hepatitis B

Condition: Chronic Hepatitis B
Interventions: Drug: ABI-H2158; Drug: Placebo for ABI-H2158
Sponsor: Assembly Biosciences
Recruiting
Study to Evaluate the Pharmacokinetics and Metabolism of [14C] CR845 (Difelikefalin) in Patients With End Stage Renal Disease on Hemodialysis and in Healthy Subjects

Conditions: Hemodialysis; Healthy
Intervention: Drug: [14C] CR845
Sponsor: Cara Therapeutics, Inc.
Completed
A Study to Investigate the Pharmacokinetics of Prolonged-release Melatonin Compared to Standard, Immediate-release Melatonin in Healthy Adults

Condition: Healthy
Interventions: Dietary Supplement: Prolonged-Release Melatonin; Dietary Supplement: Immediate-Release Melatonin
Sponsors: Pharmavite LLC; KGK Science Inc.
Recruiting
A Study Exploring the Use of Vaccine and Antigen Challenges for Immune Monitoring in Healthy Participants

Condition: Healthy
Interventions: Biological: Imvanex; Biological: Shingrix; Biological: LPS; Biological: Candin
Sponsor: Janssen Research & Development, LLC
Recruiting
An Evaluation of a Cytomegalovirus (CMV) Vaccine (ASP0113) in CMV-Seropositive and CMV-Seronegative Healthy Subjects and CMV-Seronegative Dialysis Patients

Conditions: Dialysis; Healthy Subjects; Cytomegalovirus Infection
Interventions: Drug: ASP0113; Drug: Placebo
Sponsors: Astellas Pharma Global Development, Inc.; Vical
Completed
Looking Glass: Bimanual Balanced Reaching With Visual Biofeedback

Conditions: Stroke; Stroke, Acute; Healthy
Interventions: Other: Veridical Visual Feedback; Other: Augmented Visual Feedback; Other: Healthy Comparative Reaching Task
Sponsor: Shirley Ryan AbilityLab
Recruiting
Lexical Priming by Music in Alzheimer's Disease and Healthy Aging

Condition: Alzheimer Disease
Interventions: Other: Exposure to familiar songs; Other: Music Experience Questionnaire; Other: Implicit tasks memory; Other: Questionnaires
Sponsor: Centre Hospitalier Universitaire de Saint Etienne
Recruiting
A Safety Study of LY3372689 Given By Mouth to Healthy Participants

Condition: Healthy
Interventions: Drug: LY3372689; Drug: Placebo
Sponsor: Eli Lilly and Company
Completed
Fostering Healthy Futures Efficacy Trial for Preadolescent Youth in Foster Care

Condition: Child Abuse
Interventions: Other: Assessment; Behavioral: Fostering Healthy Futures (FHF)
Sponsors: University of Colorado, Denver; National Institute of Mental Health (NIMH); The Kempe Foundation for the Prevention and Treatment of Child Abuse and Neglect
Active, not recruiting
Sweat and Gas Sensor for Healthy Skin and Atopic Dermatitis

Conditions: Healthy Adults; Atopic Dermatitis; Wearables; Sweat Sensor; Gas Sensor
Interventions: Device: Gas sensor; Device: Sweat Sensor
Sponsor: Northwestern University
Recruiting
Investigation on Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Doses of a Long-acting GLP-1 Analogue in Healthy Male Subjects and Male Subjects With Type 2 Diabetes

Conditions: Diabetes; Diabetes Mellitus, Type 2; Healthy
Interventions: Drug: semaglutide; Drug: placebo
Sponsor: Novo Nordisk A/S
Completed
A Study to Investigate the Pharmacokinetics, Safety, and Tolerability of Emicizumab in Healthy Chinese Volunteers

Conditions: Healthy Volunteers; Hemophilia A
Intervention: Drug: Emicizumab
Sponsor: Hoffmann-La Roche
Completed
Biodistribution, Dosimetry and Performance of [68Ga]Ga-DOTA-Siglec-9 in Healthy and Patients With Rheumatoid Arthritis

Conditions: Healthy Subjects; Rheumatoid Arthritis
Intervention: Other: [68Ga]Ga-DOTA-Siglec-9
Sponsor: Turku University Hospital
Active, not recruiting
Effect of Gefapixant (MK-7264/AF-219) on Cough Reflex Sensitivity in Healthy and Chronic Cough Participants (MK-7264-014)

Condition: Refractory Chronic Cough
Interventions: Drug: Gefapixant 100 mg; Drug: Placebo
Sponsor: Afferent Pharmaceuticals, Inc.
Completed
A Home-based Intervention to Improve the Diet Quality of Preschoolers

Condition: Diet Modification
Interventions: Behavioral: Healthy Feeding, Healthy Eating; Behavioral: Reading Readiness
Sponsors: University of Rhode Island; Brown University; University of Connecticut
Recruiting
A Single and Multiple Ascending Dose Study in Healthy Subjects to Assess the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of KP-1199

Condition: Analgesia
Interventions: Drug: KP-1199; Drug: Placebo oral capsule; Drug: Oxycodone oral capsule
Sponsors: Kalyra Pharmaceuticals, Inc.; United States Department of Defense; PRA Health Sciences
Recruiting
An Exploratory Study in Healthy Volunteers to Investigate the Cross-talk Between Local Drug Concentrations in the Skin and Systemic Concentrations During Topical Bioequivalence Studies Using Dermal Sampling Techniques

Conditions: Healthy; Dermal Pharmacokinetic Measurement
Interventions: Procedure: Intravenous infusion of lidocaine; Drug: Lidocaine 2.5% and Prilocaine 2.5% cream", USP (2.5% lidocaine, 2.5% prilocaine, Actavis Pharma incorporated, USA); Drug: Lidocorit 2%-Ampullen" (Gebro Pharma Gesellschaft mit beschränkter Haftung, Austria); Device: Dermal open flow microperfusion; Device: Dermal Microdialysis; Procedure: Blood sampling in dermal sampling visit; Procedure: Blood sampling in clearance visit
Sponsor: Joanneum Research Forschungsgesellschaft mbH
Recruiting
Single-Ascending-Dose Study of BIIB076 in Healthy Volunteers and Participants With Alzheimer's Disease

Conditions: Alzheimer's Disease; Healthy Volunteer
Interventions: Drug: BIIB076; Drug: Placebo
Sponsor: Biogen
Recruiting
A Study of Crisaborole Ointment 2% in Adult Japanese Healthy Subjects and Adult Japanese Subjects With Mild To Moderate Atopic Dermatitis

Conditions: Healthy; Atopic Dermatitis
Interventions: Drug: Crisaborole ointment 2%; Drug: Vehicle
Sponsor: Pfizer
Completed
Safety, Immunogenicity, and Protective Efficacy of Radiation Attenuated Plasmodium Falciparum NF54 Sporozoites (PfSPZ Vaccine) During Malaria Transmission Season in Healthy African Adult Women of Childbearing Potential in Mali

Condition: Malaria
Interventions: Biological: PfSPZ Vaccine; Other: Normal Saline
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting
Effect of Different Viscous Foods and Liquids on Swallowing Sounds

Condition: Deglutition Disorder
Intervention:
Sponsor: University of Nebraska
Completed
An Investigational Study of Experimental Medication BMS-986165 in Healthy Participants to Study Electrocardiogram Effects

Conditions: Systemic Lupus Erythematosus; Healthy Participants
Interventions: Drug: BMS-986165; Drug: Moxifloxacin; Other: Placebo
Sponsor: Bristol-Myers Squibb
Completed
A Human AME Study for Omaveloxolone

Condition: Healthy Male Subjects
Intervention: Drug: [14C]-Omaveloxolone
Sponsor: Reata Pharmaceuticals, Inc.
Recruiting
The Effect of Hyperoxia and Hypoxia on Fluorescence Lifetime Imaging Ophthalmoscopy in Healthy Subjects- a Randomized, Double Blind, Crossover Study

Condition: To Investigate the Effect of 100% Oxygen Breathing on Fluorescence Lifetime Imaging Ophthalmoscopy (FLIO) in Healthy Subjects
Interventions: Drug: SAUERSTOFF; Drug: STICKSTOFF
Sponsor: Medical University of Vienna
Not yet recruiting
PK/PD and Safety/Tolerability of Two Dosing Regimens of Oral Fosfomycin Tromethamine in Healthy Adults

Condition: Healthy Subjects
Intervention: Drug: Fosfomycin
Sponsors: Vance Fowler, M.D.; National Institute of Allergy and Infectious Diseases (NIAID)
Completed
Pharmacokinetics and Pharmacodynamics of Vicagrel in Healthy Adult Subjects of Different CYP2C19

Conditions: Healthy Subjects; PK/PD
Interventions: Drug: Vicagrel 6mg; Drug: Clopidogrel 75mg
Sponsor: Jiangsu vcare pharmaceutical technology co., LTD
Completed
Safety and Tolerability of MEDI9314 as Single Ascending Dose in Healthy Subjects

Conditions: Safety; Healthy Subjects
Interventions: Drug: MEDI9314; Drug: placebo
Sponsor: MedImmune LLC
Completed
Neural Correlates of Intern Speech

Condition: Healthy Volunteer
Interventions: Other: Healthy volunteers; Device: MRI
Sponsor: University Hospital, Grenoble
Terminated
Collection of Bone Marrow From Healthy Volunteers and Patients for the Production of Clinical Bone Marrow Stromal Cell (BMSC) Products

Condition: Bone Marrow Stromal Cells
Intervention:
Sponsor: National Institutes of Health Clinical Center (CC)
Completed
Crossover Study to Evaluate the Effect of Lemborexant Versus Placebo and Zolpidem on Postural Stability, Auditory Awakening Threshold, and Cognitive Performance in Healthy Subjects 55 Years and Older

Condition: Healthy Subjects
Interventions: Drug: LEM5; Drug: LEM10; Drug: ZOL; Drug: PBO
Sponsors: Eisai Inc.; Purdue Pharma LP
Completed
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ION-TTR-LRx in Healthy Volunteers and Patients With Hereditary Transthyretin-Mediated Amyloidosis

Conditions: Healthy Volunteers; hATTR Amyloidosis
Interventions: Drug: ION-TTR-LRx; Drug: Placebo
Sponsor: Ionis Pharmaceuticals, Inc.
Recruiting
Safety and Tolerability of SYNB1618 in Healthy Adult Volunteers and Adult Subjects With Phenylketonuria

Conditions: Phenylketonuria; Healthy
Interventions: Drug: SYNB1618; Drug: Placebo
Sponsor: Synlogic
Completed
Influenza HA Ferritin Vaccine, Alone or in Prime-Boost Regimens With an Influenza DNA Vaccine in Healthy Adults

Condition: Influenza
Interventions: Biological: VRC-FLUNPF081-00-VP (HA-F A/Sing); Biological: VRC-FLUDNA082-00-VP (DNA A/Sing)
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Active, not recruiting
Study in Healthy Volunteers to Evaluate the Efficacy and Safety of CR6261 in an H1N1 Influenza Healthy Human Challenge Model

Condition: H1N1 Influenza Healthy Volunteers
Interventions: Biological: CR6261; Biological: Placebo
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Completed
Study Assessing the Safety, Tolerability, Pharmacokinetics, Food Effect, and Drug-Drug Interactions of PTI-801 in Healthy Volunteers, and Safety, Tolerability, and Pharmacokinetics of PTI-801 in Subjects With Cystic Fibrosis

Conditions: Healthy Volunteer; Cystic Fibrosis
Interventions: Drug: PTI-801; Drug: Placebo; Drug: PTI-808
Sponsor: Proteostasis Therapeutics, Inc.
Recruiting
School Intervention Program to Promote Healthy Lifestyle Among Male Adolescent Students in King Faisal Residential City, Jeddah, Western Region, 2014-15

Conditions: Physical Activity; Sedentary Behaviors; Dietary Habits; Obesity
Intervention: Behavioral: Educational program for 2 months
Sponsor: King Abdullah International Medical Research Center
Completed
Respiratory Syncytial Virus Human Challenge in Healthy Adult Volunteers

Condition: Upper Respiratory Tract Infection
Intervention: Biological: RSV A2
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Completed
Study of Neurodegenerative Diseases Induced Stem Cells in Patients and Healthy Family Controls.

Condition: Neurodegenerative Diseases
Intervention: Genetic: Study of Neurodegenerative Diseases Induced Stem Cells
Sponsors: Neuromed IRCCS; San Raffaele University Hospital, Italy
Not yet recruiting
Effect of Food on the Pharmacokinetics of NNC0123-0000-0338 in a Tablet Formulation in Healthy Subjects

Conditions: Diabetes; Healthy
Intervention: Drug: insulin 338 (GIPET I)
Sponsor: Novo Nordisk A/S
Completed
Evaluation of [11C]RO6924963, [11C]RO6931643, and [18F]RO6958948 as Tracers for Positron Emission Tomography (PET) Imaging of Tau in Healthy and Alzheimer's Disease (AD) Participants

Condition: Alzheimer's Disease, Healthy Volunteer
Interventions: Drug: [11C]RO6924963; Drug: [11C]RO6931643; Drug: [18F]RO6958948
Sponsor: Hoffmann-La Roche
Completed
The HealthyMoms Trial to Promote Healthy Gestational Weight Gain

Conditions: Gestational Mothers; Weight Gain
Intervention: Behavioral: Mobile phone based intervention
Sponsor: Karolinska Institutet
Recruiting
The Effects of Mixed Grain on Blood Glucose and Insulin in Healthy Male

Conditions: Healthy People; Diabetes Mellitus, Type 2
Interventions: Dietary Supplement: Mixed grain 1; Dietary Supplement: Mixed grain 2; Dietary Supplement: White rice; Other: Glucose solution
Sponsor: Chonbuk National University Hospital
Completed
A Multi-centre, Open Labelled, Multiple Dosing Trial Investigating Safety, Pharmacokinetics and Pharmacodynamics of NNC 0172-2021 Administered Subcutaneously to Healthy Male Subjects and Haemophilia Subjects

Conditions: Congenital Bleeding Disorder; Haemophilia A; Healthy
Intervention: Drug: NNC172-2021
Sponsor: Novo Nordisk A/S
Terminated
Human Plasma Fatty Acid Oscillations

Conditions: Nocturnal Eating-Drinking Syndrome; Healthy
Intervention:
Sponsor: University of Pennsylvania
Recruiting
Study Of PHarmacogenetics in Ethnically Diverse Populations (SOPHIE Study)

Condition: Focus Groups
Intervention:
Sponsor: University of California, San Francisco
Active, not recruiting
A Study in Healthy Volunteers and Patients With Chronic Hepatitis B

Condition: Chronic Hepatitis B
Interventions: Drug: ABI-H0731; Drug: Placebo for ABI-H0731; Drug: Entecavir; Drug: Tenofovir disoproxil fumarate; Drug: Pegasys; Drug: Nucleos(t)ide
Sponsor: Assembly Biosciences
Completed
A Study to Demonstrate Bioequivalence Between Lorcaserin Extended Release (XR) Tablets Manufactured in Kawashima and Lorcaserin XR Tablets Manufactured in Zofingen in Healthy Participants

Condition: Healthy Participants
Interventions: Drug: Lorcaserin manufactured at Zofingen; Drug: Lorcaserin manufactured at Kawashima
Sponsor: Eisai Inc.
Completed
Class II Invariant Chain HCV Vaccine Study

Condition: Hepatitis C
Interventions: Biological: ChAd3-hliNSmut; Biological: MVA-hliNSmut
Sponsors: University of Oxford; Oxford University Hospitals NHS Trust; ReiThera Srl; European Commission; GlaxoSmithKline
Recruiting
A Single Dose Study Of PF-05161704 In Healthy Volunteers

Condition: Diabetes Mellitus, Type 2
Intervention: Drug: PF-05161704 or placebo
Sponsor: Pfizer
Completed
A Research Study of How Oral Semaglutide Tablets Work in Healthy People Who Are Chinese

Conditions: Healthy Volunteers; Diabetes Mellitus, Type 2
Interventions: Drug: Oral semaglutide; Drug: Placebo
Sponsor: Novo Nordisk A/S
Not yet recruiting
cAd3-Marburg Vaccine in Healthy Adults

Condition: Marburg Virus Disease
Intervention: Biological: cAd3-Marburg vaccine
Sponsors: National Institute of Allergy and Infectious Diseases (NIAID); US Military HIV Research Program
Active, not recruiting
A Study of LY3214996 in Healthy Participants

Condition: Healthy
Interventions: Drug: LY3214996; Drug: [14C]-LY3214996
Sponsor: Eli Lilly and Company
Recruiting
Safety, Tolerability and Immunogenicity Study of Different Vaccine Schedules With Ad26.Mos.HIV and Clade C Glycoprotein (gp)140 in Healthy Human Immunodeficiency Virus (HIV)-Uninfected Adults

Condition: Healthy
Interventions: Biological: Ad26.Mos.HIV; Biological: Clade C gp140; Drug: Placebo
Sponsor: Janssen Vaccines & Prevention B.V.
Completed
Harvest of CTCs From MBC Patients Using the Parsortix™ PC1 System

Conditions: Healthy Volunteers; Breast Cancer, Metastatic
Intervention: Diagnostic Test: Blood draw
Sponsor: Angle plc
Active, not recruiting
A Study With Iron Sucrose in Healthy Volunteers and Chronic Kidney Disease Stage 3-4 Subjects

Condition: Kidney Failure, Acute
Intervention: Drug: Iron sucrose
Sponsor: Renibus Therapuetics, Inc.
Completed
A Study to Investigate Safety and Tolerability, Pharmacokinetics and Pharmacodynamics of JNJ-63733657 in Healthy Subjects and Subjects With Alzheimer's Disease

Condition: Alzheimer Disease
Interventions: Drug: JNJ-63733657; Drug: Placebo
Sponsor: Janssen Research & Development, LLC
Active, not recruiting
A Safety Study of LY3462817 in Healthy Participants

Condition: Healthy
Interventions: Biological: LY3462817 IV; Biological: LY3462817 SC; Drug: Placebo
Sponsor: Eli Lilly and Company
Active, not recruiting
Healthy Lifestyle Intervention for High-Risk Minority Pregnant Women

Conditions: Emotional Disturbances; Depression; Pregnancy Late; Post-Partum Depression; Anxiety; Nutritional Deficiency
Intervention: Behavioral: COPE-P
Sponsors: Ohio State University; National Institutes of Health (NIH); New York University; Jacobi Medical Center; Boston College; University of Arizona; Drexel University; National Institute on Minority Health and Health Disparities (NIMHD)
Recruiting
Designing Food Voucher Programs to Reduce Disparities in Healthy Diets

Condition: Cardiovascular Diseases
Intervention: Behavioral: Vouchers
Sponsors: Stanford University; University of California, San Francisco; University of California, Irvine
Completed
A Study to Assess Safety Tolerability and Immunogenicity of Three Prime-boost Regimens of the Candidate Prophylactic Vaccines for Ebola in Healthy Adults

Condition: Healthy
Interventions: Biological: MVA-BN-Filo; Biological: Ad26.ZEBOV; Biological: Placebo
Sponsor: Janssen Vaccines & Prevention B.V.
Completed
Food Effect Study of Single Dose of Fruquintinib (HMPL-013) in Healthy Subjects

Condition: Food Effect of Fruquintinib in Health Subjects
Intervention: Drug: fruquintinib
Sponsor: Hutchison Medipharma Limited
Completed
Pharmacokinetics and Safety in Healthy Volunteers

Condition: Healthy
Interventions: Drug: SCT630; Drug: adalimumab-EU source
Sponsor: Sinocelltech Ltd.
Not yet recruiting
Trial of a New Online Programme for Physical Activity and Healthy Eating.

Condition: Overweight/Obesity
Interventions: Behavioral: Website and pedometer intervention; Other: Control
Sponsor: University of Bath
Completed
Study of LY3154207 in Healthy Participants

Condition: Healthy
Interventions: Drug: LY3154207; Drug: [14C]-LY3154207
Sponsor: Eli Lilly and Company
Completed
A Study of LY3451838 in Healthy Participants

Condition: Healthy
Interventions: Drug: LY3451838; Drug: Placebo
Sponsor: Eli Lilly and Company
Recruiting
A Study to Test Safety, Tolerability, and the Way the Body Absorbs, Distributes, and Gets Rid of a Study Drug Called MOR106, in Healthy Subjects and in Patients With Moderate to Severe Atopic Dermatitis

Conditions: Healthy; Atopic Dermatitis
Interventions: Drug: MOR106; Drug: Placebo
Sponsor: Galapagos NV
Recruiting
Study of Dendrogenin A / Oxysterols Balance Between Healthy Volunteers and Acute Myeloid Leukemia Patients

Condition: Acute Myeloid Leukemia
Interventions: Biological: Blood sample; Biological: Bone marrow sample
Sponsor: University Hospital, Toulouse
Completed
Multiple Dose Study of DS-1971a

Condition: Healthy
Interventions: Drug: DS-1971a; Drug: placebo
Sponsor: Daiichi Sankyo, Inc.
Completed
A Study of Ixekizumab in Healthy Participants

Condition: Healthy
Intervention: Biological: Ixekizumab
Sponsor: Eli Lilly and Company
Completed
A Study in Healthy Japanese Men to Test How Different Doses of BI 690517 Are Taken up in the Body and How Well They Are Tolerated

Condition: Healthy
Interventions: Drug: BI 690517; Drug: Placebo
Sponsor: Boehringer Ingelheim
Completed
A Study of LY900014 in Healthy Chinese Participants

Condition: Healthy
Interventions: Drug: LY900014; Drug: Insulin Lispro (Humalog)
Sponsor: Eli Lilly and Company
Not yet recruiting
Endocannabinoid and Psychological Responses to Yoga in Healthy Adults

Condition: Healthy
Interventions: Behavioral: Yoga; Behavioral: Quiet Rest
Sponsor: University of Wisconsin, Madison
Completed
A Study of LY3502970 in Healthy Participants

Condition: Healthy
Interventions: Drug: LY3502970; Drug: Placebo
Sponsor: Eli Lilly and Company
Recruiting
Effects of 20,000 EU of Clinical Center Reference Endotoxin (CCRE) Versus Placebo(ENDOHEART)

Condition: Healthy
Interventions: Drug: Clinical Center Reference Endotoxin (CCRE); Drug: Normal saline
Sponsors: University of North Carolina, Chapel Hill; Environmental Protection Agency (EPA); RTI International; United States Department of Defense
Completed
An Interaction Study of LY3200882 in Healthy Participants

Condition: Healthy
Interventions: Drug: LY3200882; Drug: Itraconazole
Sponsor: Eli Lilly and Company
Completed
Study of Ixekizumab in Healthy Participants

Condition: Healthy
Intervention: Biological: Ixekizumab
Sponsor: Eli Lilly and Company
Completed
Study to Evaluate the Safety, Biodistribution, Radiation Dosimetry and Tumor Imaging Potential of [131I]-SGMIB Anti-HER2 VHH1 in Healthy Volunteers and Breast Cancer Patients

Conditions: Healthy Volunteers; Breast Cancer
Intervention: Biological: [131I]-SGMIB Anti-HER2 VHH1
Sponsor: Camel-IDS NV
Completed
TDCS Effects on Motor Learning and Motor Control in Healthy Subjetcs

Condition: Healthy
Intervention: Device: transcranial direct current stimularion
Sponsor: Centro Universitario La Salle
Recruiting
Study to Compare 2 Formulations of LY900014 in Healthy Participants

Condition: Healthy
Interventions: Drug: LY900014 U-200; Drug: LY900014 U-100
Sponsor: Eli Lilly and Company
Completed
Third Ward Wellness Study for Families

Condition: Child Obesity
Interventions: Behavioral: FUNPALs Playgroup; Behavioral: Healthy Toddler Parent Group
Sponsor: University of Houston
Active, not recruiting
A Study of the Kinetics of Lymphoid Cells in Patients With Monoclonal B-cell Lymphocytosis (MBL), Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL), Mantle Cell Lymphoma (MCL) and Healthy Volunteers

Conditions: Lymphoma, Mantle-cell; CLL (Chronic Lymphocytic Leukemia); Monoclonal B-Cell Lymphocytosis; Healthy Volunteers; Small Lymphocytic Lymphoma
Intervention:
Sponsors: National Heart, Lung, and Blood Institute (NHLBI); Northwell Health
Recruiting
Pharmacokinetics (PK) of 20 mg Teduglutide in Participants With Moderately Impaired Hepatic Function Compared to Healthy Participants

Condition: Hepatic Impairment
Intervention: Drug: Teduglutide
Sponsor: Shire
Completed
Normal Immunological Parameters Among Healthy Volunteers in Kambila, Mali

Condition: Malaria
Intervention:
Sponsors: National Institute of Allergy and Infectious Diseases (NIAID); University of Bamako
Recruiting
A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD5718 After Single and Multiple Ascending Dose Administration to Healthy Male Subjects

Conditions: Healthy Male Subjects; Cardiovascular Disease
Interventions: Drug: AZD5718 oral suspension crystalline form (1 to 100 mg/mL) (Part A); Drug: AZD5718 oral suspension amorphous (1 to 100 mg/mL) (Part A); Drug: AZD5718 placebo oral suspension; Drug: AZD5718 oral suspension amorphous (1 to 100 mg/mL) (Part B)
Sponsor: AstraZeneca
Completed
Promoting Healthy Development With the Recipe 4 Success Intervention

Conditions: Obesity; Poverty
Interventions: Behavioral: Recipe 4 Success; Behavioral: Treatment as Usual Early Head Start
Sponsors: University of Wisconsin, Madison; Penn State University
Completed
A Study of LY3316531 in Healthy Participants

Condition: Healthy
Interventions: Drug: LY3316531; Drug: Placebo
Sponsor: Eli Lilly and Company
Completed
A Study Investigating the Safety, Absorption and Elimination of GLPG3312, a New Drug in the Treatment of Inflammatory Diseases

Condition: Healthy
Interventions: Drug: GLPG3312 IR; Drug: Placebo; Drug: GLPG3312 MR; Drug: GLPG3312 FE MR
Sponsor: Galapagos NV
Recruiting
Comparative Study of Pharmacokinetics, Pharmacodynamics, Safety, and Immunogenicity of Single Intravenous Doses of BCD-148 and Soliris®

Condition: Healthy Subjects
Interventions: Biological: BCD-148; Biological: Soliris
Sponsor: Biocad
Completed
Influence of CBD on Episodic Memory in Healthy Subjects

Condition: Healthy
Interventions: Drug: Verum; Drug: Placebo
Sponsor: Prof. Dominique de Quervain, MD
Completed
What the Body Does to Foliglurax in Healthy Volunteers

Condition: Healthy
Intervention: Drug: Foliglurax
Sponsor: H. Lundbeck A/S
Completed
A Study in Healthy Men to Test Whether Rifampicin Influences the Amount of BI 894416 in the Blood

Condition: Healthy
Interventions: Drug: BI 894416; Drug: Rifampicin
Sponsor: Boehringer Ingelheim
Recruiting
Acute Effects of Inspiratory Muscle Training at Different Intensities in Healthy People

Condition: Healthy
Interventions: Device: Inspiratory muscle training; Other: Diaphragmatic breathing
Sponsor: Dokuz Eylul University
Completed
A Study of LY3314814 in Healthy Participants

Condition: Healthy
Interventions: Drug: LY3314814; Drug: [13C415N3] LY3314814
Sponsors: Eli Lilly and Company; AstraZeneca
Completed
A Food Effect Study in Healthy Volunteers With PT2977 Tablets

Condition: Healthy
Intervention: Drug: PT2977
Sponsor: Peloton Therapeutics, Inc.
Completed
Single and Multiple Oral Administration Study of ASP015K in Healthy Nonelderly Volunteers

Conditions: Pharmacokinetics of ASP015K; Healthy Volunteer
Interventions: Drug: peficitinib; Drug: Placebo
Sponsor: Astellas Pharma Inc
Completed
Effects of SERT Inhibition on the Subjective Response to Psilocybin in Healthy Subjects

Condition: Healthy
Interventions: Drug: Escitalopram; Drug: Placebo oral capsule
Sponsor: University Hospital, Basel, Switzerland
Recruiting
Food Effect Study of CTP-543 in Healthy Volunteers

Condition: Healthy
Intervention: Drug: CTP-543
Sponsor: Concert Pharmaceuticals
Completed
A Study of LY3463251 in Healthy Participants

Condition: Healthy
Interventions: Drug: LY3463251; Drug: Placebo
Sponsor: Eli Lilly and Company
Recruiting
Safety, Pharmacokinetic Study of PRIC in Healthy Adult Subjects

Condition: Healthy
Interventions: Drug: PRIC; Drug: Pranlukast hydrate
Sponsor: SamA Pharmaceutical Co., Ltd
Not yet recruiting
Lithium Effects on Reward Processing and Reappraisal in Healthy Volunteers

Condition: Healthy
Interventions: Drug: Lithium; Other: Placebo - Rayotabs
Sponsor: University of Oxford
Completed
Impact of BC Farmers' Market Nutrition Coupon Program on Diet Quality and Psychosocial Well-being of Low-income Adults

Conditions: Diet, Healthy; Health Risk Behaviors
Interventions: Other: Food coupons; Other: Nutrition skill-building
Sponsors: University of Calgary; Canadian Institutes of Health Research (CIHR); British Columbia Farmers' Market Nutrition Coupon Program
Recruiting
The Healthy Elderly Longevity Cohort

Condition: Healthy
Intervention:
Sponsor: Scripps Translational Science Institute
Recruiting
A Study of Tirzepatide (LY3298176) in Healthy Participants

Condition: Healthy
Interventions: Drug: Tirzepatide; Drug: Placebo
Sponsor: Eli Lilly and Company
Completed
Analysis of Cortical Biomarkers for PD

Conditions: Parkinson Disease; Healthy
Interventions: Other: Parkinson's disease patients; Other: No drug
Sponsor: Universidade Federal de Pernambuco
Recruiting
A Study of Injections of LY3074828 in Healthy Participants

Condition: Healthy
Interventions: Drug: LY3074828; Device: PFS; Device: AI
Sponsor: Eli Lilly and Company
Active, not recruiting
A Study of Baricitinib in Healthy Participants

Condition: Healthy
Interventions: Drug: Baricitinib suspension; Drug: Baricitinib tablet
Sponsor: Eli Lilly and Company
Completed
The Safety and Intake Rate of a Natural Compound Arctigenin in Healthy Men

Condition: Healthy
Intervention: Dietary Supplement: Arctigenin
Sponsors: University of California, Los Angeles; Charles Drew University of Medicine and Science
Recruiting
Short-bout Handgrip Exercise Intervention

Condition: Smoking (Tobacco) Addiction
Interventions: Behavioral: Exercise condition; Behavioral: Healthy diet condition
Sponsor: The University of Hong Kong
Not yet recruiting
Abuse Potential of Single Doses of Lorcaserin in Healthy Recreational Polydrug Users

Conditions: Drug Abuse; Healthy
Interventions: Drug: Placebo; Drug: Active Comparator #1; Drug: Active Comparator #2; Drug: Active Comparator #3; Drug: Lorcaserin Dose #1; Drug: Lorcaserin Dose #2; Drug: Lorcaserin Dose #3
Sponsor: Eisai Inc.
Completed
Bone Mineral Content in Healthy Children

Condition: Healthy
Intervention: Device: No intervention
Sponsor: Arkansas Children's Hospital Research Institute
Active, not recruiting
A Study of Different Injectable Formulations of LY3375880 in Healthy Participants

Condition: Healthy
Interventions: Drug: LY3375880; Drug: Buffer Matrix (No LY3375880); Device: Autoinjector (AI); Device: Manual Syringe
Sponsor: Eli Lilly and Company
Active, not recruiting
A Study in Healthy Men to Test How Itraconazole Influences the Amount of BI 1323495 in the Blood

Condition: Healthy
Interventions: Drug: BI 1323495; Drug: Itraconazole
Sponsor: Boehringer Ingelheim
Completed
A Study of a Single Subcutaneous Dose of JNJ-26366821 in Healthy Participants

Condition: Healthy
Interventions: Drug: JNJ-26366821; Drug: Placebo
Sponsor: Janssen Research & Development, LLC
Recruiting
Impact of Anti-platelet Drug Exposure on Platelet mRNA Splicing in Healthy Subjects

Condition: Thrombosis; Artery
Intervention: Drug: Ticagrelor Oral Tablet [Brilinta]
Sponsors: George Washington University; National Institute on Minority Health and Health Disparities (NIMHD); Shenandoah University; GWU Medical Faculty Associates
Not yet recruiting
The Impact of Leg Immobilization on Postabsorptive and Postprandial Muscle Protein Breakdown in Healthy Young Males

Condition: Healthy
Interventions: Other: Postabsorptive; Other: Postprandial; Procedure: Immobilisation
Sponsor: University of Exeter
Recruiting
Study of Potential for Drug Interactions Mediated by CYP3A4 Inhibition With Aramchol in Healthy Volunteers

Condition: Healthy
Interventions: Drug: Aramchol; Drug: Midazolam; Drug: Atorvastatin
Sponsors: Galmed Pharmaceuticals Ltd; Hammersmith Medicines Research; Analyst Research Laboratories; Alderley Analytical; Diamond Pharma Services Regulatory Affairs Consultancy
Completed
A Study in Healthy Men to Measure the Amount of BI 730357 in the Blood When Taken as a Tablet

Condition: Healthy
Interventions: Drug: BI 730357; Drug: BI 730357 mixed with [C-14] BI 730357 BS
Sponsor: Boehringer Ingelheim
Completed
Evaluation of Methods for Measuring Gastrointestinal Transit and Food Reward in Healthy Individuals - The PRESET Study

Condition: Healthy Participants
Interventions: Other: Standard mixed breakfast meal; Other: SmartBar™
Sponsors: Kristine Færch; University of Copenhagen; iMotions A/S; University of Leeds; Aalborg University Hospital
Completed
A Study in Healthy Men to Measure the Amount of BI 425809 in the Blood When Taken as a Tablet

Condition: Healthy
Interventions: Drug: BI 425809; Drug: BI 425809 mixed with [C-14]-BI 425809
Sponsor: Boehringer Ingelheim
Completed
Training on Unstable Surfaces and Effects on the Balance of Healthy Young People

Condition: Healthy
Interventions: Other: Unstable; Other: Stable
Sponsor: University of Valencia
Completed
A Study in Healthy Men to Test How Itraconazole Influences the Amount of BI 1358894 in the Blood

Condition: Healthy
Interventions: Drug: BI 1358894; Drug: Itraconazole
Sponsor: Boehringer Ingelheim
Completed
Pharmacokinetic Characteristics of GLH1SM Extended Release Tablets in Healthy Volunteers(Fed)

Condition: Healthy
Interventions: Combination Product: Janumet XR tablet 100/1000 mg; Combination Product: GLH1SM tablet 100/1000 mg
Sponsor: GL Pharm Tech Corporation
Enrolling by invitation
A Study of Two Formulations of LY3074828 in Healthy Participants

Condition: Healthy
Interventions: Biological: LY3074828; Drug: LY3074828; Device: Auto-injector (AI); Device: Prefilled syringe (PFS)
Sponsor: Eli Lilly and Company
Completed
A Study in Healthy Men to Test How Itraconazole Influences the Amount of BI 1291583 in the Blood

Condition: Healthy
Interventions: Drug: BI 1291583; Drug: Itraconazole
Sponsor: Boehringer Ingelheim
Completed
Pharmacokinetic Characteristics of GLH1SM Extended Release Tablets in Healthy Volunteers

Condition: Healthy
Interventions: Combination Product: Janumet XR tablet 100/1000 mg; Combination Product: GLH1SM tablet 100/1000 mg
Sponsor: GL Pharm Tech Corporation
Completed
Single Dose Mass Balance Study With C14 - Labeled AAI101 in Healthy Male Volunteers

Condition: Healthy
Intervention: Drug: 1 µCi of 14C-AAI101 + 500 mg AAI101
Sponsor: Allecra
Completed
A Study to Evaluate the Effect of Omeprazole on the Pharmacokinetics of BMS-986205 in Healthy Participants

Condition: Healthy
Interventions: Drug: BMS-986205; Drug: omeprazole
Sponsor: Bristol-Myers Squibb
Completed
A Study in Healthy Men to Test How Itraconazole Influences the Amount of BI 730357 in the Blood

Condition: Healthy
Interventions: Drug: BI 730357; Drug: Itraconazole
Sponsor: Boehringer Ingelheim
Completed
Spatial Analysis of the Intestinal Microbiota in Healthy Subjects

Condition: Healthy Subjects
Intervention:
Sponsors: Örebro University, Sweden; Region Örebro County
Active, not recruiting
A Study in Healthy Men to Test Whether Food Affects the Amount of BI 894416 in the Blood

Condition: Healthy
Intervention: Drug: BI 894416
Sponsor: Boehringer Ingelheim
Completed
Study in Healthy Subjects to Compare Two Tablet Formulations of Memantine (Ebixa®) in Fasted and Fed Conditions

Condition: Healthy
Interventions: Drug: Lactose-free memantine; Drug: Memantine
Sponsor: H. Lundbeck A/S
Completed
In Vivo Assessment of Glutamine Utilization by Bone Marrow Plasma Cells

Condition: Healthy
Interventions: Other: 5-13C-Glutamine; Other: Bone marrow aspiration
Sponsor: Mayo Clinic
Active, not recruiting
A Validation of a Genomics Based Prognostic in Severe Trauma

Conditions: Trauma; Complications; Multiple Organ Failure
Interventions: Other: Traumatized population; Other: Healthy Volunteers
Sponsors: University of Florida; National Institutes of Health (NIH); National Institute of General Medical Sciences (NIGMS); Massachusetts General Hospital
Completed
A Study in Healthy Men to Test How Itraconazole Influences the Amount of BI 894416 in the Blood

Condition: Healthy
Interventions: Drug: Itraconazole; Drug: BI 894416
Sponsor: Boehringer Ingelheim
Completed
A Study to Evaluate the Safety and Tolerability of JNJ-67670187 in Healthy Participants

Condition: Healthy
Interventions: Biological: JNJ-67670187; Biological: Placebo
Sponsor: Janssen Research & Development, LLC
Active, not recruiting
The Effect of a Botanical Plant Extract on Gut Health, Immunity and Metabolic Disorders in Healthy Adults

Condition: Healthy
Interventions: Dietary Supplement: Low dose response efficacy of plant extracts; Dietary Supplement: Middle dose response efficacy of plant extracts; Dietary Supplement: High Dose response efficacy of plant extracts; Dietary Supplement: Placebo
Sponsor: University of Roehampton
Not yet recruiting
The Effect of a Talocrural Thrust Manipulation on Lateral Ankle Ligament Integrity in a Subgroup of Healthy Individuals

Condition: Healthy
Intervention: Procedure: Distraction thrust manipulation
Sponsor: Florida Gulf Coast University
Recruiting
A Study in Healthy People to Test How Combining BI 1467335 and Tyramine Affects Blood Pressure

Condition: Healthy
Interventions: Drug: BI 1467335; Drug: Placebo; Drug: Phenelzine sulfate; Drug: Tyramine
Sponsor: Boehringer Ingelheim
Recruiting
A Study Investigating Formulations of Vortioxetine Applied Under the Tongue in Healthy Subjects

Condition: Healthy
Interventions: Drug: Vortioxetine IV; Drug: Vortioxetine SLA; Drug: Vortioxetine SLB; Drug: Vortioxetine SLC
Sponsor: H. Lundbeck A/S
Completed
Study in Healthy Subjects to Determine the Effect of an Inhibitor on Exposure to Relacorilant and Its Metabolites

Condition: Healthy
Interventions: Drug: Relacorilant 350mg; Drug: Itraconazole; Drug: Relacorilant 300mg
Sponsor: Corcept Therapeutics
Recruiting
Impact of a Health and Mental Health Promotion Intervention Among Jordanians and Syrians.

Conditions: Mental Stress; Hypertension; Diabetes
Interventions: Behavioral: Healthy community clinic NCD+MH; Behavioral: Healthy community clinic NCD
Sponsors: University of Illinois at Urbana-Champaign; Americares; Royal Health Awareness Society
Completed
A Study to Test How Food Influences the Amount of BI 1291583 in the Blood of Healthy Men

Condition: Healthy
Intervention: Drug: BI 1291583
Sponsor: Boehringer Ingelheim
Completed
A Study to Assess the Drug-Drug Interaction Between Bedaquiline and Clarithromycin in Healthy Adult Participants

Condition: Healthy
Interventions: Drug: Bedaquiline; Drug: Clarithromycin
Sponsor: Janssen Research & Development, LLC
Completed
A Study to Test How Food Influences the Amount of BI 1323495 in the Blood of Healthy Men

Condition: Healthy
Intervention: Drug: BI 1323495,
Sponsor: Boehringer Ingelheim
Completed
"The Effects of Clinical Pilates Exercises on Cognitive Functions and Speed of Movement in Healthy Young Adults"

Condition: Healthy
Interventions: Other: Clinic Pilates Group; Other: Aerobic Exercise Group; Other: Control Group
Sponsors: Biruni University; Istanbul University
Completed
Comparison of ALD, NASH, and Healthy Control Patients

Condition: ALD - Alcoholic Liver Disease
Intervention: Other: Blood draw
Sponsor: The Cleveland Clinic
Recruiting
The Effect of Exercise on Pain Sensitivity in a Population With Ongoing Neck Pain Compared to Healthy Controls

Conditions: Neck Pain; Healthy
Intervention: Other: Exercise
Sponsor: Aalborg University
Not yet recruiting
Single + Multiple Ascending Dose and Food Effect Study of AZD7986 in Healthy Volunteers, PK, PD and Safety Study

Condition: Safety, Pharmacokinetics, Pharmacodynamics, Food Effect
Interventions: Drug: AZD7986, oral solution, 1 to 50 mg/mL; Drug: Placebo, oral solution
Sponsor: AstraZeneca
Completed
A Taste Assessment of BMS-986165 in Healthy Participants

Condition: Healthy Participants
Interventions: Drug: BMS-986165; Drug: Active Pharmaceutical Ingredient
Sponsor: Bristol-Myers Squibb
Recruiting
Safety, Efficacy of FFP From Healthy Donors to AmeliorateFrailty and Enhance Immune Function in Older Individuals

Condition: Frailty
Intervention: Drug: GMFFP
Sponsor: Dipnarine Maharaj
Enrolling by invitation
A Study of Lanabecestat (LY3314814) in Healthy Participants When Taken With Rosuvastatin

Condition: Healthy
Interventions: Drug: Lanabecestat; Drug: Rosuvastatin
Sponsors: Eli Lilly and Company; AstraZeneca
Completed
Cardiorespiratory Fitness in Prediabetic,Type 2 Diabetic and Healthy Individuals

Conditions: Prediabetic State; Diabetes Mellitus, Type 2; Cardiorespiratory Fitness; Inflammation; Exercise Test
Intervention: Diagnostic Test: Cardiorespiratory Fitness
Sponsor: Hacettepe University
Recruiting
Cortiment® MMX Pharmacokinetic Study

Condition: Healthy
Intervention: Drug: Budesonide
Sponsor: Ferring Pharmaceuticals
Not yet recruiting
A Study in Healthy Men That Tests if Taking BI 1265162 by Mouth, Intravenously, or Inhaled Influences the Amount of BI 1265162 in the Blood

Condition: Healthy
Interventions: Drug: BI 1265162 (T1); Drug: BI 1265162 (T2); Drug: BI 1265162 (R); Drug: BI 1265162 (T3)
Sponsor: Boehringer Ingelheim
Recruiting
Study Investigating the Safety and Tolerability of Lu AF88434 in Healthy Young Men

Condition: Healthy
Interventions: Drug: Lu AF88434; Drug: Lu AF99722 14C spiked dosage ([14C]-radiolabelled Lu AF88434); Drug: Lu AF99723 14C spiked dosage ([14C]-radiolabelled Lu AF88434); Drug: Placebo
Sponsor: H. Lundbeck A/S
Recruiting
Kinematics and Kinetics of Gait Perturbations in Young Healthy Adults

Condition: Balance Disorders
Intervention: Diagnostic Test: Reaction for gait perturbation
Sponsor: Barbara Łysoń
Completed
First-In-Human Study of BBT-401-1S Following Single and Multiple Ascending Doses in Healthy Volunteers

Condition: Ulcerative Colitis
Interventions: Drug: BBT-401-1S, Single dose; Drug: BBT-401-1S, Multiple doses; Drug: Placebo
Sponsors: Bridge Biotherapeutics, Inc.; KCRN Research, LLC
Completed
Study of the Safety of USB005 in Healthy Volunteers

Condition: Healthy Volunteers
Interventions: Drug: USB005 (aclerastide) Ophthalmic Solution; Drug: USB005 Ophthalmic Solution Placebo
Sponsors: US Biotest, Inc.; United States Department of Defense
Completed
A Study of Abemaciclib in Healthy Participants

Condition: Healthy
Interventions: Drug: Abemaciclib Capsules (Reference Formulation); Drug: Abemaciclib Tablet (Test Formulation)
Sponsor: Eli Lilly and Company
Completed
Safety and Immunogenicity of MT-5625 in Healthy Adults, Toddlers and Infants

Condition: Healthy
Interventions: Biological: MT-5625 low dose; Biological: MT-5625 middle dose; Biological: MT-5625 high dose; Biological: Rotarix; Biological: Placebo
Sponsor: Mitsubishi Tanabe Pharma Corporation
Completed
A Comparative Study of New Formulation and Approved Formulation for Levothyroxine in Healthy Volunteers

Condition: Healthy
Interventions: Drug: Reference Eutirox®; Drug: Test Eutirox®
Sponsor: Merck Healthcare KGaA, Darmstadt Germany, an affiliate of Merck KGaA, Darmstadt, Germany
Not yet recruiting
Reliability of an Objective Measurement to Assess Lumbar Spine Motion in Healthy Controls and in Low Back Pain Patients

Conditions: Reliability, Validity of Measurement to Assess Lumbar Spine Motion; Comparison of Healthy Subjects and Low Back Pain Patients
Intervention:
Sponsor: Ruhr University of Bochum
Completed
A Study of Lanabecestat (LY3314814) in Healthy Participants

Condition: Healthy
Intervention: Drug: Lanabecestat
Sponsors: Eli Lilly and Company; AstraZeneca
Completed
A Study of Galcanezumab in Healthy Participants.

Condition: Healthy
Intervention: Biological: Galcanezumab
Sponsor: Eli Lilly and Company
Completed
A Study in Evaluating Bioequivalence Between Test and Reference Formulations of Vadadustat Tablets in Healthy Adults

Condition: Healthy
Interventions: Drug: vadadustat reference tablets; Drug: vadadustat test tablets
Sponsor: Akebia Therapeutics
Completed
Effect of a Multi-component Education Program on Salt Reduction in Adults

Conditions: Blood Pressure; Hypertension
Interventions: Behavioral: Multi-component education program on salt reduction; Behavioral: Generic healthy lifestyle program
Sponsors: Academia Cuf Descobertas; NOVA Medical School; Jeronimo Martins
Recruiting
A Study in Healthy Male Volunteers to Look at How the Test Medicine GLPG1690 is Taken up by the Body When Given by Mouth and Into a Vein as an Injection

Condition: Healthy
Interventions: Drug: GLPG1690 film-coated tablets; Drug: [14C]-GLPG1690 solution for infusion; Drug: [14C]-GLPG1690 capsules
Sponsor: Galapagos NV
Completed
The Safety, Tolerability And Pharmacokinetics Of Single Ascending Doses And The Effect Of Food On Oral WCK 4873 In Healthy Adult Volunteers

Condition: Healthy
Interventions: Drug: WCK 4873; Drug: Placebo Oral Tablet
Sponsor: Wockhardt
Completed
Blood Component Collection From Patients With Rheumatic or Kidney Disease and Healthy Volunteers

Conditions: Rheumatic Diseases; Healthy Volunteers
Intervention:
Sponsor: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Recruiting
Bioequivalence Study of a Test Capsule Formulation of Fingolimod With the Reference Capsule Formulation of Fingolimod

Condition: Healthy Volunteers
Interventions: Drug: Fingolimod Reference Formulation; Drug: Fingolimod Test Formulation
Sponsors: Asofarma S.A.I. y C.; Zenith Technology Corporation Limited
Completed
A Drug-drug Interaction Study of Lanabecestat (LY3314814) in Healthy Participants

Condition: Healthy
Interventions: Drug: Lanabecestat; Drug: Dabigatran etexilate
Sponsors: Eli Lilly and Company; AstraZeneca
Completed
Oesophageal Acid Exposure in Healthy Subjects Over 96 Hours

Condition: Gastroesophageal Reflux
Intervention: Device: Bravo
Sponsor: Guy's and St Thomas' NHS Foundation Trust
Completed
Assessment of [18F]MNI-1054 as a Marker for LSD1

Condition: Healthy Volunteers (HV)
Intervention: Drug: [18F]MNI-1054
Sponsor: Invicro
Completed
Single and Multiple Ascending Dose and Food Effect PK Study in Healthy Adult and Elderly Subjects

Condition: Healthy
Interventions: Drug: RDN-929; Drug: Placebo oral capsule; Drug: RDN-929 TBD dose
Sponsors: Rodin Therapeutics; QPS Netherlands B.V.
Completed

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