Find Research Studies for Healthy Volunteers in Alberta

Endocannabinoid and Psychological Responses to Yoga in Healthy Adults

Condition: Healthy
Interventions: Behavioral: Yoga; Behavioral: Quiet Rest
Sponsor: University of Wisconsin, Madison
Completed
Healthy Parent Carers

Condition: Health Behavior
Interventions: Behavioral: Healthy Parent Carers group programme; Behavioral: Healthy Parent Carers online resources
Sponsors: University of Exeter; University of Oxford
Not yet recruiting
A Study to Compare the Blood Level of Bimekizumab Injected Subcutaneously Either by a Prefilled Syringe or by an Autoinjector in Adult Healthy Volunteer Participants

Condition: Healthy Volunteers
Intervention: Drug: Bimekizumab
Sponsor: UCB Biopharma S.P.R.L.
Not yet recruiting
A Novel Mouthwash Formulation CTP/BNZ With Mucus Adhesive Polymer

Condition: Healthy
Interventions: Drug: Cetylpyridinium Chloride 0.05% + Benzydamine HCl 0.15% + mucus adhesive polymer; Drug: Cetylpyridinium Chloride 0.05% + Benzydamine HCl 0.15%
Sponsors: Aziende Chimiche Riunite Angelini Francesco S.p.A; Cross Research S.A.
Completed
A Study to Evaluate the Relative Bioavailability (BA) and Effect of Food on TAK-831 Tablet Formulations in Healthy Participants

Condition: Healthy Volunteers
Interventions: Drug: TAK-831 T2; Drug: TAK-831 T3
Sponsor: Millennium Pharmaceuticals, Inc.
Not yet recruiting
Effect of Food on the Pharmacokinetics of TEW-7197 in Healthy Subjects

Condition: Healthy Volunteers
Intervention: Drug: TEW-7197
Sponsor: MedPacto, Inc.
Enrolling by invitation
Serum Insulin Response After Acute and Chronic Sucralose Ingestion in Healthy Volunteers With Variable Body Mass Index

Condition: Healthy
Intervention: Dietary Supplement: sucralose 48 mg (splenda)/day for ten weeks
Sponsor: Hospital General de México Dr. Eduardo Liceaga
Completed
A Study to Evaluate the Absorption, Distribution, Metabolism, Excretion and Absolute Bioavailability of AG-348 in Healthy Male Participants Following Administration of a Single Oral Dose of [14C]AG-348 and Concomitant Single Intravenous Microdose of [13C6]AG-348

Condition: Healthy Volunteers
Interventions: Drug: AG-348; Drug: [13C6]AG-348
Sponsor: Agios Pharmaceuticals, Inc.
Completed
Compare the Pharmacokinetic of K-877 Controlled Release (CR) and Immediate Release (IR) Tablets in Healthy Adults.

Condition: Healthy
Interventions: Drug: K-877 CR Tablet A; Drug: K-877 CR Tablet B; Drug: K-877 CR Tablet E; Drug: K-877 IR Tablet
Sponsor: Kowa Research Institute, Inc.
Not yet recruiting
The Safety and Intake Rate of a Natural Compound Arctigenin in Healthy Men

Condition: Healthy
Intervention: Dietary Supplement: Arctigenin
Sponsors: University of California, Los Angeles; Charles Drew University of Medicine and Science
Not yet recruiting
A Study in Healthy Adult Volunteers to Assess the Safety and Pharmacokinetics of an Investigational Imaging Product

Condition: Healthy Subjects
Interventions: Drug: ASP5354; Drug: Placebo
Sponsor: Astellas Pharma Global Development, Inc.
Not yet recruiting
The Healthy Moms Study: Comparison of a Post-Partum Weight Loss Intervention Delivered Via Facebook or In-Person Groups

Conditions: Weight Loss; Diet Modification; Physical Activity
Intervention: Behavioral: Healthy Moms
Sponsors: University of Connecticut; University of Massachusetts, Worcester; Worcester Polytechnic Institute; National Heart, Lung, and Blood Institute (NHLBI)
Recruiting
A Study to Assess Administration of an Oral Anti-thrombotic With Antiplatelet Therapy in Healthy Subjects

Condition: Healthy Volunteers
Interventions: Drug: BMS-986177; Drug: Aspirin; Drug: Clopidogrel; Drug: Placebo (for BMS-986177)
Sponsor: Bristol-Myers Squibb
Recruiting
Development of a New Immunotherapy Using Intramuscular Administration of Autologous Total IgG

Condition: Immunotherapy
Interventions: Biological: Part A) Healthy subjects; Biological: Part B) Advanced solid tumor
Sponsor: Ajou University School of Medicine
Not yet recruiting
A Study to Evaluate the Effect of JNJ-53718678 on the Cardiac Repolarization Interval in Healthy Adult Participants

Condition: Healthy
Interventions: Drug: JNJ-53718678, 2000 mg; Drug: JNJ-53718678, 3000 mg; Drug: JNJ-53718678, 500 mg; Drug: JNJ-53718678 Placebo; Drug: Moxifloxacin 400 mg; Drug: Moxifloxacin Placebo
Sponsor: Janssen Research & Development, LLC
Not yet recruiting
A Study of LY3361237 in Healthy Participants

Condition: Healthy
Interventions: Drug: LY3361237 - SC; Drug: LY3361237 - IV; Drug: Placebo - SC; Drug: Placebo - IV
Sponsor: Eli Lilly and Company
Not yet recruiting
A Study to Assess Bioquivalence Between a Novel Naproxen Sodium 275 mg Film-coated Tablet and Nalgesin Naproxen Sodium 275 mg Film-coated Tablet in Healthy Adult Volunteers

Condition: Healthy
Interventions: Drug: Naproxen sodium (test product); Drug: Naproxen sodium (reference product)
Sponsor: McNeil AB
Not yet recruiting
A Study to Investigate Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA Gamma 8) Receptor Occupancy of JNJ-64140284 With Newly Developed Transmembrane AMPA Receptor Regulatory Protein (TARP)-Gamma 8 Positron Emission Tomography (PET) [18F]JNJ-64511070 in Healthy Men

Condition: Healthy
Interventions: Drug: JNJ-64140284; Drug: Fluorine-18 Labeled [18F]-JNJ-64511070
Sponsor: Janssen Research & Development, LLC
Not yet recruiting
Assessment of [18F]MNI-1054 as a Marker for LSD1

Condition: Healthy Volunteers (HV)
Intervention: Drug: [18F]MNI-1054
Sponsor: Invicro
Recruiting
Safety, Tolerability, PK and PD of SAD or MAD of APX-115 in Healthy Male Volunteers

Conditions: Healthy; Safety
Interventions: Drug: SAD: APX-115; Drug: SAD: Placebo; Drug: MAD: APX-115; Drug: MAD: Placebo; Other: Food effect: fasted and fed; Other: Metabolic probe with or without APX-115
Sponsor: Aptabio Therapeutics, Inc.
Recruiting
Phase 1, Safety and Bronchopulmonary PK Study in Healthy Volunteers

Condition: Healthy Subjects
Interventions: Drug: TP-6076; Procedure: Bronchoalveolar lavage
Sponsors: Tetraphase Pharmaceuticals, Inc.; PRA Health Sciences
Not yet recruiting
Drug-drug Interaction Study of Ozanimod With Tyramine to Evaluate the Effect on Pressor Response

Condition: Healthy Volunteer
Interventions: Drug: Phenelzine; Drug: Tyramine; Drug: Phenelzine placebo; Drug: ozanimod placebo; Drug: ozanimod
Sponsor: Celgene
Recruiting
Immunogenicity and Safety Study of a Quadrivalent Meningococcal Conjugate Vaccine Administered Concomitantly With Routine Pediatric Vaccines in Healthy Infants and Toddlers

Condition: Healthy Volunteers (Meningococcal Infection)
Interventions: Biological: Meningococcal Polysaccharide (Serogroups A,C,Y and W) Tetanus Toxoid Conjugate vaccine MenACYW conjugate vaccine; Biological: Meningococcal (Groups A, C, Y and W 135) Oligosaccharide Diphtheria CRM197 Conjugate Vaccine; Biological: Meningococcal Polysaccharide (serogroups A,C,Y and W-135) Diphtheria Toxoid Conjugate Vaccine; Biological: Diphtheria and Tetanus Toxoids and Acellular Pertussis, inactivated Poliovirus and Haemophilus b Conjugate Vaccine; Biological: Diphtheria and Tetanus Toxoids and Acellular Pertussis, Hepatitis B and Inactivated Poliovirus Vaccine; Biological: Haemophilus b Conjugate Vaccine; Biological: Pneumococcal 13-valent Conjugate Vaccine; Biological: Rotavirus Vaccine, Live, Oral, Pentavalent; Biological: Hepatitis B Vaccine; Biological: Measles, Mumps, and Rubella Virus Vaccine Live; Biological: Varicella Virus Vaccine Live
Sponsor: Sanofi Pasteur, a Sanofi Company
Recruiting
A Study of LY3451838 in Healthy Participants

Condition: Healthy
Interventions: Drug: LY3451838; Drug: Placebo
Sponsor: Eli Lilly and Company
Not yet recruiting
Effect of Ivermectin Metabolites on Mosquito Survival

Condition: Healthy
Intervention: Drug: Ivermectin
Sponsor: University of Oxford
Not yet recruiting
A Study of JNJ-63733657 in Healthy Japanese Participants

Condition: Healthy
Interventions: Drug: JNJ-63733657; Drug: Placebo
Sponsor: Janssen Pharmaceutical K.K.
Recruiting
Phase 1 Study of TAK-831 in Healthy Adult Asian Subjects

Condition: Healthy Adult Asian Participants
Interventions: Drug: TAK-831; Drug: Placebo
Sponsor: Takeda
Not yet recruiting
A Study to Test Safety, Tolerability, and the Way the Body Absorbs, Distributes, and Gets Rid of a Study Drug Called MOR106, in Healthy Subjects and in Patients With Moderate to Severe Atopic Dermatitis

Conditions: Healthy; Atopic Dermatitis
Interventions: Drug: MOR106; Drug: Placebo
Sponsor: Galapagos NV
Recruiting
Investigation of AAI101 Safety, Tolerability & PK in Healthy Volunteers

Condition: Healthy
Interventions: Drug: AAI101 i.v.; Drug: Saline 0.9% infusion; Drug: Piperacillin i.v.; Drug: Cefepime i.v.
Sponsor: Allecra
Completed
Class II Invariant Chain HCV Vaccine Study

Condition: Hepatitis C
Interventions: Biological: ChAd3-hliNSmut; Biological: MVA-hliNSmut
Sponsors: University of Oxford; Oxford University Hospitals NHS Trust; ReiThera Srl; European Commission; GlaxoSmithKline
Recruiting
A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of MA-0211 in Healthy Adult Subjects Including a Food Effect Cohort

Condition: Healthy Volunteers
Interventions: Drug: MA-0211; Drug: Placebo
Sponsor: Astellas Pharma Global Development, Inc.
Completed
A Study of Seltorexant (JNJ-42847922) After Single-Dose Administration in Healthy Participants

Condition: Healthy
Interventions: Drug: Seltorexant 40 mg; Drug: Seltorexant 20 mg
Sponsors: Janssen Research & Development, LLC; Minerva Neurosciences
Not yet recruiting
Study of Neurodegenerative Diseases Induced Stem Cells in Patients and Healthy Family Controls.

Condition: Neurodegenerative Diseases
Intervention: Genetic: Study of Neurodegenerative Diseases Induced Stem Cells
Sponsors: Neuromed IRCCS; San Raffaele University Hospital, Italy
Not yet recruiting
A Study to Investigate the Safety of AB680 in Healthy Volunteers

Condition: Healthy Volunteers
Interventions: Drug: AB680; Other: Placebo
Sponsor: Arcus Biosciences, Inc.
Not yet recruiting
Single Ascending Dose (SAD) and Multiple Ascending Dose (MAD) Study of M5049 in Healthy Participants

Condition: Healthy
Interventions: Drug: M5049; Drug: Placebo
Sponsor: Merck KGaA
Not yet recruiting
Study to Compare Pharmacokinetic Property of SYO-1644 Tab. and Nexavar Tab. in Healthy Male Volunteers

Condition: Healthy, Male
Interventions: Drug: SYO-1644; Drug: Nexavar tab
Sponsors: Samyang Biopharmaceuticals Corporation; Seoul National University Hospital
Not yet recruiting
Tacrolimus Blood Levels After Topical Application of Tacrolimus on Healthy Skin

Condition: Healthy
Intervention: Drug: topical formulation of tacrolimus
Sponsor: LEO Pharma
Not yet recruiting
Metabolic Availability of Methionine From Mung Beans in Healthy Young Adult Men

Condition: Healthy
Intervention: Other: Dietary Intakes
Sponsors: The Hospital for Sick Children; Canadian Institutes of Health Research (CIHR)
Recruiting
Safety of a Quadrivalent Meningococcal Conjugate Vaccine Administered Concomitantly With Routine Pediatric Vaccines in Healthy Infants and Toddlers

Condition: Healthy Volunteers (Meningococcal Infection)
Interventions: Biological: Meningococcal polysaccharide (serogroups A,C,Y and W) tetanus toxoid conjugate vaccine (MenACYW conjugate vaccine); Biological: Meningococcal (Groups A, C, Y and W 135) Oligosaccharide Diphtheria CRM197 Conjugate Vaccine (MENVEO®); Biological: Diphtheria, Tetanus, Acellular Pertussis, Poliovirus and Haemophilus b Vaccine; Biological: Pneumococcal 13-valent Conjugate Vaccine; Biological: Rotavirus Vaccine; Biological: Hepatitis B Vaccine; Biological: Measles, Mumps, and Rubella Virus Vaccine; Biological: Varicella Virus Vaccine
Sponsor: Sanofi Pasteur, a Sanofi Company
Recruiting
A Phase 1 Study to Assess the Safety of NLY01 in Healthy Subjects

Condition: Safety and Tolerability in Healthy Volunteers
Intervention: Drug: NLY01
Sponsor: Neuraly, Inc.
Recruiting
Study With Lu AF35700 in Healthy Men and Women in Fasting and Fed State

Condition: Healthy
Interventions: Drug: Lu AF35700; Drug: Lu AF35700 iv
Sponsor: H. Lundbeck A/S
Recruiting
Safety, Tolerability and PK/PD of SHR1459 in Healthy Volunteers

Condition: Healthy Volunteers
Intervention: Drug: SHR1459
Sponsor: Jiangsu HengRui Medicine Co., Ltd.
Recruiting
Study in Healthy Subjects to Compare Two Tablet Formulations of Memantine (Ebixa®) in Fasted and Fed Conditions

Condition: Healthy
Interventions: Drug: Lactose-free memantine; Drug: Memantine
Sponsor: H. Lundbeck A/S
Recruiting
A Pharmacokinetic Study of Omaveloxolone in Healthy Volunteers

Condition: Healthy
Intervention: Drug: omaveloxolone
Sponsor: Reata Pharmaceuticals, Inc.
Not yet recruiting
A Study to Investigate the Effects of Cortexolone 17α-propionate (and Its Metabolites) on Healthy Volunteers' Heart

Condition: Healthy Volunteers
Interventions: Drug: Cortexolone 17α-propionate solution; Drug: Placebo
Sponsor: Cassiopea SpA
Recruiting
Single and Multiple Ascending Dose and Food Effect PK Study in Healthy Adult and Elderly Subjects

Condition: Healthy
Interventions: Drug: RDN-929; Drug: Placebo oral capsule; Drug: RDN-929 TBD dose
Sponsors: Rodin Therapeutics; QPS Netherlands B.V.
Recruiting
A Study in Healthy Men to Test How BI 730357 is Processed by the Body

Condition: Healthy
Intervention: Drug: BI 730357 mixed with [C-14]BI 730357 BS
Sponsor: Boehringer Ingelheim
Recruiting
A Study to Determine the Effects of PF-04965842 on the Pharmacokinetics of Oral Contraceptive Steroids in Healthy Female Subjects

Condition: Healthy Females
Interventions: Drug: PF-04965842; Drug: Ethinyl estradiol (EE) and levonorgestrel (LN)
Sponsor: Pfizer
Recruiting
An Investigational Study of Experimental Medication BMS-986165 in Healthy Participants

Condition: Healthy Participants
Interventions: Drug: BMS-986165; Drug: MMF
Sponsor: Bristol-Myers Squibb
Recruiting
A Study of Two Formulations of LY3074828 in Healthy Participants

Condition: Healthy
Interventions: Biological: LY3074828; Drug: LY3074828; Device: Auto-injector (AI); Device: Prefilled syringe (PFS)
Sponsor: Eli Lilly and Company
Recruiting
Production of a Device to Obtain Continuous Ambulatory Vestibular Assessment (CAVA) - Healthy Volunteer Trial

Condition: Optokinetic Nystagmus
Intervention: Device: CAVA
Sponsors: Emily Woodhouse; University of East Anglia; Medical Research Council
Recruiting
A Study to Investigate the Safety, Tolerability and Pharmacokinetics of RD01 (Pegerythropoietin) in Healthy Chinese Volunteers

Condition: Healthy
Interventions: Drug: RD01; Drug: Placebo
Sponsor: Shengzhen Sciprogen Bio-pharmaceutical Co. Ltd
Recruiting
A Study in Healthy Subjects to Investigate Whether Administration of Clazosentan Can Affect Normal Heart Function

Condition: Healthy Subjects
Interventions: Drug: Clazosentan; Drug: Placebo; Drug: Moxifloxacin
Sponsor: Idorsia Pharmaceuticals Ltd.
Not yet recruiting
Study of CVN424 in Healthy Subjects

Condition: Healthy
Interventions: Drug: CVN424; Drug: Placebo
Sponsor: Cerevance Beta, Inc.
Recruiting
Effects of VitaBeard® on Facial Hair Growth in Healthy Adult Men

Condition: Healthy
Interventions: Dietary Supplement: Multivitamin; Dietary Supplement: Placebo
Sponsors: Do Vitamins Inc.; Nutrasource Diagnostics Inc.
Completed
Study to Evaluate the Abuse Potential of ACT-541468 in Healthy Recreational Drug Users

Condition: Healthy Recreational Drug Users
Interventions: Drug: ACT-541468; Drug: Suvorexant; Drug: Zolpidem; Drug: Placebo
Sponsor: Idorsia Pharmaceuticals Ltd.
Recruiting
Pharmacokinetics, Dialysability and Safety of P03277 in Healthy Volunteers and in Patients With Impaired Renal Function

Conditions: Renal Insufficiency; Healthy Volunteers
Intervention: Drug: P03277
Sponsor: Guerbet
Recruiting
A Study to Evaluate the PF-06700841 Effect on QTc Interval in Healthy Volunteers

Condition: Healthy
Interventions: Drug: PF-06700841; Drug: Placebo; Drug: moxifloxacin
Sponsor: Pfizer
Recruiting
A Study in Healthy Men to Find Out How BI 425809 is Taken up and Handled by the Body

Condition: Healthy
Intervention: Drug: BI 425809 mixed with [C-14] BI425809
Sponsor: Boehringer Ingelheim
Recruiting
Safety, Tolerability, Pharmacokinetic Characteristics of hzVSF-v13 in Healthy Male Volunteers

Condition: Healthy
Interventions: Drug: hzVSF-v13; Drug: Placebo
Sponsor: ImmuneMed, Inc.
Not yet recruiting
The Study of a Selective 5-ht6 Receptor Antagonist, HEC30654AcOH,in Healthy Subjects

Condition: Healthy
Interventions: Drug: HEC30654AcOH capsule; Drug: Placebo capsule
Sponsor: Sunshine Lake Pharma Co., Ltd.
Enrolling by invitation
Effects of Perampanel on Neurophysiology Test Perimeters

Condition: Healthy
Intervention: Drug: Perampanel 6 MG
Sponsors: Weill Medical College of Cornell University; Eisai Inc.
Recruiting
SP16 SERPIN-like Peptide Administration in Healthy Individuals

Condition: Healthy Participants
Interventions: Drug: SP16; Drug: Placebos
Sponsors: Serpin Pharma, LLC; George Mason University; Virginia Commonwealth University
Recruiting
Study by 2D-strain of the Ventricular Wall Motion During Postnatal Adaptation

Condition: Healthy
Intervention: Other: Echocardiography
Sponsors: University Hospital, Grenoble; TIMC-IMAG
Recruiting
Comparing of the Pharmacokinetic, Safety and Pharmacodynamic of QL1206 and Xgeva® in Healthy Adults

Condition: Healthy People
Interventions: Drug: QL1206; Drug: Xgeva®
Sponsor: Qilu Pharmaceutical Co., Ltd.
Recruiting
A Clinical Trial to Evaluate Tolerability and Pharmacokinetics of HL217 Eye Drop in Healthy Male Subjects

Condition: Healthy Subject
Interventions: Drug: Cohort 1: HL217 Ophathalmic Solution QD; Drug: Cohort 2: HL217 Ophathalmic Solution BID; Drug: Cohort 3: HL217 Ophthalmic Solution QID; Drug: Placebo Ophthalmic solution
Sponsor: Hanlim Pharm. Co., Ltd.
Completed
Reliability of [18F]-FTC-146 Brain Uptake in Healthy Controls

Condition: Healthy Controls
Intervention: Drug: [18F]-FTC-146
Sponsor: Stanford University
Not yet recruiting
A Study to Evaluate Bioavailability and Food Effect of Selumetinib (AZD6244) in Healthy Male Participants

Conditions: Neurofibromatosis Type 1 (NF1)-Related Plexiform Neurofibromas (PNs); Healthy Participants
Interventions: Drug: Treatment A; Drug: Treatment B; Drug: Treatment C; Drug: Treatment D; Drug: Acetaminophen
Sponsor: AstraZeneca
Active, not recruiting
A Dose-escalation Clinical Trial After Multiple Dosing of HL217 Eye Drop in Healthy Male Subjects

Condition: Healthy Subjects
Interventions: Drug: Cohort 1: HL217 Ophathalmic Solution BID; Drug: Cohort 2: HL217 Ophathalmic Solution QID; Drug: Placebo
Sponsor: Hanlim Pharm. Co., Ltd.
Active, not recruiting
A Study of Single and Multiple Ascending Doses of JNJ-61393215 in Healthy Participants

Condition: Healthy
Interventions: Drug: JNJ-61393215; Drug: Placebo
Sponsor: Janssen Research & Development, LLC
Recruiting
Clinical Trial to Assess the Pharmacokinetic Characteristics of Lodivixx Tab. 5/160mg in Healthy Male Subjects (N=27)

Condition: Healthy Male Subjects
Interventions: Drug: Exforge tab. 10/160mg; Drug: Lodivixx tab. 5/160mg
Sponsor: Hanlim Pharm. Co., Ltd.
Completed
Suction Based Characterization of Healthy and Diseased Skin

Condition: Systemic Sclerosis
Interventions: Device: Measurment with Aspirational Medical Device; Device: Measurment with Cutometer MPA 580
Sponsors: Oliver Distler; Swiss Federal Institute of Technology
Enrolling by invitation
A Phase 1 Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single and Multiple Doses of IONIS-ENaCRx in Healthy Volunteers

Condition: Healthy Subjects
Interventions: Drug: IONIS-ENaCRx; Drug: Placebo
Sponsor: Ionis Pharmaceuticals, Inc.
Not yet recruiting
Family Healthy Living Early Intervention Program

Conditions: Obesity; Health Behavior; Child Behavior; Child Obesity; Nutrition Disorders; Body Weight
Intervention: Behavioral: Family Healthy Living
Sponsors: University of Victoria; Childhood Obesity Foundation
Recruiting
Safety, Tolerability, and Pharmacokinetics of REGN5069 in Healthy Volunteers

Condition: Healthy Volunteer
Interventions: Drug: REGN5069; Drug: Placebo
Sponsor: Regeneron Pharmaceuticals
Recruiting
Motor Evoked Potentials With Modified Facilitation Technique

Condition: Multiple Sclerosis
Interventions: Diagnostic Test: MEP using standard facilitation technique; Diagnostic Test: MEP using modified facilitation technique
Sponsor: University Hospital, Basel, Switzerland
Recruiting
Study to Evaluate the Pharmacokinetics of Mucinex 600 mg Extended-release Bi-layer Tablet in Healthy Volunteers

Condition: Healthy Subjects
Intervention: Drug: Mucinex® ER 600 mg
Sponsor: Reckitt Benckiser Inc.
Completed
Analysis of Cortical Biomarkers for PD

Conditions: Parkinson Disease; Healthy
Interventions: Other: Parkinson's disease patients; Other: No drug
Sponsor: Universidade Federal de Pernambuco
Recruiting
Bioequivalence Study Comparing Mucinex Extended-release 600 mg Tablets to Immediate-release Guaifenesin 600 mg in Healthy Volunteers

Condition: Healthy Subjects
Interventions: Drug: Mucinex® SE; Drug: Vicks Cough Syrup for Chesty Coughs
Sponsor: Reckitt Benckiser Inc.
Completed
A Study of SYNT001 in Healthy Volunteers

Condition: Healthy
Interventions: Drug: SYNT001; Drug: Placebo
Sponsor: Syntimmune, Inc.
Completed
Phase 1 Study to Evaluate ASN002 Absorption, Metabolism, and Excretion of [14C] Following a Single Oral Dose in Healthy Male Subjects

Condition: Healthy Volunteer
Intervention: Drug: [14C] ASN002
Sponsor: Asana BioSciences
Not yet recruiting
Drug-drug Interaction Study of Ozanimod With Pseudoephedrine to Evaluate the Effect on Blood Pressure and Heart Rate

Condition: Healthy Volunteers
Interventions: Drug: ozanimod; Drug: Pseudoephedrine; Drug: ozanimod placebo
Sponsor: Celgene
Recruiting
Study to Characterize the Pharmacokinetics of 3 Marketed Products Containing 200 mg Guaifenesin in Healthy Volunteers.

Condition: Healthy Subjects
Interventions: Drug: Vicks Cough Syrup for Chesty Coughs; Drug: Robitussin Extra Strength Chest Congestion; Drug: Organ-I- NR tablet
Sponsor: Reckitt Benckiser Inc.
Completed
Bioequivalence Study of CJ-30060 in Healthy Male Volunteers

Condition: Healthy Male Subjects
Interventions: Drug: Exforge® tab 10/160mg, Crestor® tab 20mg; Drug: CJ-30060 10/160/20mg
Sponsor: CJ HealthCare Corporation
Completed
Healthy Marriage and Responsible Fatherhood Grant Program With Phoenix House of New York

Conditions: Relationship, Family; Substance Use; Parenting
Intervention: Behavioral: Within My Reach/ Within Our Reach
Sponsors: Phoenix House Foundation, Inc.; New York University
Recruiting
Drug Interaction Study Evaluating the Effect of Rifampin on PK and Safety of PF 04965842.

Condition: Healthy
Interventions: Drug: PF-04965842; Other: rifampin
Sponsor: Pfizer
Recruiting
A Study in Evaluating Bioequivalence Between Test and Reference Formulations of Vadadustat Tablets in Healthy Adults

Condition: Healthy
Interventions: Drug: vadadustat reference tablets; Drug: vadadustat test tablets
Sponsor: Akebia Therapeutics
Completed
Implant Pharmacokinetic and Pharmacodynamic Study

Condition: Healthy
Interventions: Drug: Afamelanotide Group 1; Drug: Afamelanotide Group 2
Sponsor: Clinuvel Pharmaceuticals Limited
Completed
An Investigational Study to Evaluate the Effects of Experimental Medication BMS-986256 in Healthy Participants

Condition: Healthy Participants
Interventions: Drug: BMS-986256; Other: Placebo
Sponsor: Bristol-Myers Squibb
Recruiting
Single Ascending Dose Trial Investigating Safety, Tolerability and Pharmacokinetics of BDM-2 in Healthy Male Subjects.

Condition: Healthy
Intervention: Drug: BDM-2 in Bottle (50 mg - 3600 mg); oral suspension
Sponsors: Hivih; Venn Life Sciences
Completed
A First in Human Study in Healthy Volunteers and in Participants With Frontotemporal Dementia With Granulin Mutation

Conditions: Healthy; Frontotemporal Dementia
Interventions: Biological: AL001; Other: Placebo
Sponsor: Alector Inc.
Recruiting
A Phase I Study of SB26 in Healthy Volunteers

Condition: Healthy Volunteers
Interventions: Drug: SB26; Drug: Placebo
Sponsor: Samsung Bioepis Co., Ltd.
Recruiting
Non-inferiority Evaluation of Pain Intensity After Biomatrop (Somatropin) Application in Relation to Hormotrop (Somatropin), in Healthy Subjects

Condition: Healthy Subjects
Interventions: Drug: Recombinant human growth hormone - Biomatrop; Drug: Recombinant human growth hormone - Hormotrop
Sponsor: Ache Laboratorios Farmaceuticos S.A.
Not yet recruiting
Safety and Immunogenicity of a Quadrivalent Meningococcal Conjugate Vaccine When Administered Concomitantly With Routine Pediatric Vaccines in Healthy Infants and Toddlers in the Philippines, the Russian Federation, and Mexico

Condition: Healthy Volunteers (Meningococcal Infection)
Interventions: Biological: Meningococcal Polysaccharide (Serogroups A, C, Y, and W) Tetanus Toxoid Conjugate Vaccine MenACYW conjugate vaccine; Biological: Meningococcal (Groups A, C, Y and W 135) Oligosaccharide Diphtheria CRM197 Conjugate Vaccine; Biological: Measles, Mumps, and Rubella Virus Vaccine Live; Biological: Varicella Virus Vaccine; Biological: Pneumococcal 13-valent Conjugate Vaccine; Biological: Diphtheria, tetanus, pertussis (acellular component), hepatitis B, poliomyelitis (inactivated), and Haemophilus influenzae type b conjugate vaccine; Biological: Diphtheria, Tetanus, Pertussis (Acellular, Component) Poliomyelitis (inactivated) Vaccine, and Haemophilus influenza type b Conjugate Vaccine; Biological: Hepatitis B Vaccine; Biological: Rotavirus Vaccine, Live, Pentavalent; Biological: Japanese encephalitis vaccine (live, attenuated)
Sponsor: Sanofi Pasteur, a Sanofi Company
Not yet recruiting
A Study to Demonstrate Bioequivalence Between Lorcaserin Extended Release (XR) Tablets Manufactured in Kawashima and Lorcaserin XR Tablets Manufactured in Zofingen in Healthy Participants

Condition: Healthy Participants
Interventions: Drug: Lorcaserin manufactured at Zofingen; Drug: Lorcaserin manufactured at Kawashima
Sponsor: Eisai Inc.
Completed
A Study of Safety, Tolerability, and Pharmacokinetics of Single Doses of PHP-303 in Healthy Subjects

Condition: Healthy Volunteer
Interventions: Drug: PHP-303; Other: Placebo
Sponsor: pH Pharma
Recruiting
This Study in Healthy People Tests Whether Taking a Low Strength of Empagliflozin, Linagliptin, and Metformin Together in 1 Pill is the Same as Taking Them in Separate Pills

Condition: Healthy
Interventions: Drug: Empagliflozin (fixed dose combination); Drug: Linagliptin (fixed dose combination); Drug: Metformin HCl (fixed dose combination); Drug: Empagliflozin; Drug: Linagliptin; Drug: Metformin HCl
Sponsors: Boehringer Ingelheim; Eli Lilly and Company
Active, not recruiting
Influence of CBD on Episodic Memory in Healthy Subjects

Condition: Healthy
Interventions: Drug: Verum; Drug: Placebo
Sponsor: Prof. Dominique de Quervain, MD
Recruiting
An Evaluation Of Healthy Ankle Motion And Morphology

Condition: Healthy Ankle
Interventions: Radiation: Cone Beam Computed Tomography; Radiation: Radiographs
Sponsors: Paragon 28; Focus Medical Design and Development
Active, not recruiting
Drug-drug Interaction Study of Ozanimod With Inhibitor or Inducer of CYP2C8 and/or CYP3A

Condition: Healthy Volunteer
Interventions: Drug: Ozanimod; Drug: Gemfibrozil; Drug: Itraconazole; Drug: Rifampin
Sponsor: Celgene
Recruiting
Effects of 20,000 EU of Clinical Center Reference Endotoxin (CCRE) Versus Placebo(ENDOHEART)

Condition: Healthy
Interventions: Drug: Clinical Center Reference Endotoxin (CCRE); Drug: Normal saline
Sponsors: University of North Carolina, Chapel Hill; Environmental Protection Agency (EPA); RTI International; United States Department of Defense
Recruiting
A Study to Assess the Safety, Tolerability and Pharmacokinetics of Subcutaneous (SC) Injections of JNJ-64565111 in Healthy Male Japanese Participants and to Assess Pharmacokinetics Following Subcutaneous Injections of JNJ-64565111 in Healthy Male Caucasian Participants

Condition: Healthy
Interventions: Drug: JNJ-64565111; Drug: Placebo
Sponsor: Janssen Pharmaceutical K.K.
Recruiting
Determination of Normal Reference Values of CRP, Procalcitonin, and Lactate Levels for the Nanōmix eLab® System

Condition: Healthy
Intervention:
Sponsor: Nanomix
Active, not recruiting
Effect of Secretin in Functional Dyspepsia and Healthy Subjects

Conditions: Dyspepsia; Healthy
Interventions: Drug: Human Secretin; Drug: Placebo
Sponsor: Mayo Clinic
Not yet recruiting
Study of LY3154207 in Healthy Participants

Condition: Healthy
Interventions: Drug: LY3154207; Drug: [14C]-LY3154207
Sponsor: Eli Lilly and Company
Recruiting
Study to Compare 2 Formulations of LY900014 in Healthy Participants

Condition: Healthy
Interventions: Drug: LY900014 U-200; Drug: LY900014 U-100
Sponsor: Eli Lilly and Company
Recruiting
A Study in Healthy People to Measure the Amount of BI 655130 in the Blood After Injecting Different Doses Into Different Parts of the Body

Condition: Healthy
Intervention: Drug: BI 655130
Sponsor: Boehringer Ingelheim
Recruiting
Pilot Trial Investigating Fermented Whey Supplementation in Healthy Adults

Condition: Healthy
Intervention: Dietary Supplement: Molkosan
Sponsors: University of Aberdeen; A. Vogel
Completed
Clinical Trial Testing the BioSerenity Pulse Oximeter (EOXY) Efficacy, Performance and Safety in Healthy Volunteer

Condition: Healthy
Interventions: Device: EOXY device; Device: Gold standard oximeter; Procedure: SaO2 sampling
Sponsors: BioSerenity; NAMSA-CRO; Université Catholique de Louvain
Active, not recruiting
New Infant Formula Supports Adequate Growth in Healthy Infants

Condition: Infant Development
Interventions: Other: Formula A; Other: Formula B
Sponsor: Worthy Health
Not yet recruiting
Study C3S : Comparison Among Healthy Subject

Condition: Healthy Volunteers
Intervention: Device: Comparative standard echocardiography between two devices : Vivid 9 General Electric and Epiq 7 Philips
Sponsor: University Hospital, Clermont-Ferrand
Recruiting
Pharmacokinetics and Pharmacodynamics of CinnoVex (Interferon Beta-1a) Compared to Avonex (Interferon Beta-1a)

Conditions: Bioequivalence; Healthy
Intervention: Drug: Interferon Beta-1A
Sponsor: Cinnagen
Recruiting
Lu AF82422 in Healthy Non-Japanese and Japanese Subjects and in Patients With Parkinson's Disease

Conditions: Healthy; Parkinson Disease
Interventions: Drug: Lu AF82422; Drug: Placebo
Sponsor: H. Lundbeck A/S
Recruiting
A Study of Benzathine Benzylpenicillin Intramuscular Injection in Japanese Healthy Subjects

Condition: Healthy
Intervention: Drug: penicillin G benzathine
Sponsor: Pfizer
Completed
Study of the Safety of USB005 in Healthy Volunteers

Condition: Healthy Volunteers
Interventions: Drug: USB005 (aclerastide) Ophthalmic Solution; Drug: USB005 Ophthalmic Solution Placebo
Sponsors: US Biotest, Inc.; United States Department of Defense
Recruiting
To Evaluate PK and Safety Profile of Oral MAD of Separately Using TG-2349, DAG181 or Combination in Healthy Chinese Volunteers

Condition: Healthy Chinese Volunteers
Interventions: Drug: TG-2349 (400 mg) plus DAG181 (200 mg); Drug: DAG181 (200 mg) plus TG-2349 (400 mg)
Sponsors: Dongguan HEC TaiGen Biopharmaceuticals Co., Ltd.; R&G Pharma Studies Co.,Ltd.
Completed
A Study to Investigate the Drug-drug Interactions Between ACT-541468 and Ethanol in Healthy Subjects

Condition: Healthy
Interventions: Drug: ACT-541468; Other: ACT-541468 placebo; Other: Ethanol 10%; Other: Ethanol placebo
Sponsor: Idorsia Pharmaceuticals Ltd.
Completed
A Study of LY3316531 in Healthy Participants

Condition: Healthy
Interventions: Drug: LY3316531; Drug: Placebo
Sponsor: Eli Lilly and Company
Not yet recruiting
To Evaluate the Safety, Tolerability, and Pharmacokinetics Profile in Healthy Chinese Volunteers of TG-2349

Condition: Healthy Chinese Volunteers
Interventions: Drug: Furaprevir capsule (SAD); Drug: Furaprevir capsule (MAD); Drug: Placebo (SAD); Drug: Placebo (MAD)
Sponsors: Dongguan HEC TaiGen Biopharmaceuticals Co., Ltd.; R&G Pharma Studies Co.,Ltd.
Completed
A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of JNJ-64264681 in Healthy Male and Female Participants

Condition: Healthy
Interventions: Drug: JNJ-64264681; Drug: Placebo
Sponsor: Janssen Research & Development, LLC
Recruiting
Study of A4250 in Healthy Volunteers Under Fasting, Fed and Sprinkled Conditions

Condition: Healthy Volunteers
Intervention: Drug: A4250
Sponsors: Albireo; Celerion
Completed
A Study in Healthy Japanese Men to Test How Different Doses of BI 690517 Are Taken up in the Body and How Well They Are Tolerated

Condition: Healthy
Interventions: Drug: BI 690517; Drug: Placebo
Sponsor: Boehringer Ingelheim
Recruiting
A Study to Investigate the Effect of JNJ-64565111 on Cardiac Repolarization (Corrected QT Interval) Compared With Placebo in Healthy Adults: a Thorough ECG Study Employing Placebo, JNJ-64565111, and a Positive Control (Moxifloxacin)

Condition: Healthy
Interventions: Drug: JNJ-64565111; Drug: Moxifloxacin; Drug: JNJ-64565111-matching Placebo; Drug: Moxifloxacin-matching Placebo
Sponsor: Janssen Research & Development, LLC
Recruiting
A Study to Test the Safety and Tolerability and Pharmacokinetics of Single Doses of UCB0107 in Healthy Japanese Subjects

Condition: Healthy Japanese Volunteers
Interventions: Drug: UCB0107; Other: Placebo
Sponsor: UCB Biopharma S.P.R.L.
Recruiting
A Study in Healthy Volunteers to Investigate How Much Test Medicine [14C]-Uproleselan is Taken up by the Body When Administered Directly Into the Vein (IV)

Condition: Healthy Subjects
Intervention: Drug: Uproleselan
Sponsors: GlycoMimetics Incorporated; Quotient Sciences
Not yet recruiting
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of MRG-110 Following Intradermal Injection in Healthy Volunteers

Condition: Healthy Volunteer
Interventions: Drug: MRG-110; Drug: Placebo
Sponsor: miRagen Therapeutics, Inc.
Recruiting
Program of Healthy Lifestyle Promotion in Yaqui Indigenous in Sonora

Conditions: Overweight; Obesity
Intervention: Behavioral: Healthy lifestyle promotion program
Sponsor: Centro de Investigación en Alimentación y Desarrollo A.C.
Recruiting
Pharmacokinetics, Pharmacodynamics Profile and Tolerance of P03277 in Healthy Subjects and Patients With Brain Lesions

Conditions: Healthy Volunteers; Brain Lesion
Interventions: Drug: P03277; Drug: Placebo
Sponsor: Guerbet
Completed
Healthy Start to Feeding Intervention

Conditions: Weight, Body; Diet Habit
Intervention: Behavioral: Healthy Start to Feeding
Sponsors: University of Cincinnati; Children's Hospital Medical Center, Cincinnati
Not yet recruiting
Singe Dose, First in Human Study of PF- 06946860 in Healthy Adult Subjects

Condition: Healthy
Interventions: Biological: PF-06946860; Other: Placebo
Sponsor: Pfizer
Recruiting
A Single and Multiple Dose Study of PF-05221304 in Healthy Japanese Adults

Condition: Healthy
Interventions: Drug: PF-05221304; Drug: Placebo
Sponsor: Pfizer
Recruiting
Clinical Study of TS-143 in Healthy Adult Male Subjects (Multiple-Dose Administration)

Condition: Healthy Participants
Interventions: Drug: TS-143; Drug: Placebo
Sponsor: Taisho Pharmaceutical Co., Ltd.
Completed
Study Investigating a Single Oral Dose of Fenebrutinib in Healthy Volunteers

Condition: Healthy Participants
Intervention: Drug: Fenebrutinib
Sponsor: Hoffmann-La Roche
Completed
A Study in Healthy Volunteers and Patients With Chronic Hepatitis B

Conditions: Hepatitis B; Infectious Disease; Liver Diseases
Interventions: Drug: CRV431; Drug: Placebo; Drug: TDF
Sponsor: ContraVir Pharmaceuticals, Inc.
Recruiting
A Study in Healthy Male Subjects to Investigate Whether Administration of Rifampicin Can Affect the Fate of Clazosentan in the Body of Clazosentan

Condition: Healthy Subjects
Interventions: Drug: Clazosentan; Drug: Rifampicin; Other: Saline (0.9% sodium chloride)
Sponsor: Idorsia Pharmaceuticals Ltd.
Recruiting
MUNIX Variability in Healthy Subjects

Condition: Healthy
Intervention: Other: MUNIX
Sponsor: Assistance Publique Hopitaux De Marseille
Not yet recruiting
A Study to Assess the Effect of Ritonavir on the Single-Dose Pharmacokinetics of JNJ-61393215 in Healthy Participants

Condition: Healthy
Interventions: Drug: JNJ-61393215; Drug: Ritonavir
Sponsor: Janssen Research & Development, LLC
Active, not recruiting
A Study to Evaluate ACT-246475 Fate in Healthy Male Subjects

Condition: Healthy Subjects
Intervention: Drug: ACT-246475
Sponsor: Idorsia Pharmaceuticals Ltd.
Completed
Clinical Study of TS-143 in Healthy Adult Male Subjects (Single-Dose Administration)

Condition: Healthy Participants
Interventions: Drug: TS-143; Drug: Placebo
Sponsor: Taisho Pharmaceutical Co., Ltd.
Completed
Semi-manual Vessel Density Analysis on Optical Coherence Tomography Angiography Images of Healthy Adults

Condition: Healthy
Intervention: Device: Optical coherence tomography angiography (Zeiss Cirrus HD OCT 5000 AngioPlex)
Sponsor: Semmelweis University
Active, not recruiting
Investigating the Acute Effects of Blueberry (Poly)Phenols on Vascular Function and Cognition in Healthy Individuals.

Condition: Healthy
Interventions: Dietary Supplement: Wild Blueberry Powder; Dietary Supplement: Placebo
Sponsors: King's College London; University of Reading
Recruiting
Isolation of Circulating Pulmonary Cells in COPD and Its Relationship With Clinical Relevant Outcomes (IbICEnCa)

Conditions: COPD; COPD Exacerbation; COPD, Severe Early-Onset
Intervention: Diagnostic Test: Isolation of Circulating Pulmonary Cells in peripheral blood
Sponsors: Hospital de Alta Resolucion de Loja. Agencia Sanitaria Hospital de Poniente; Universidad de Granada; Genyo- Centro Pfizer- Universidad de Granada-Junta de Andalucia de genómica e investigación oncológica
Not yet recruiting
Third Ward Wellness Study for Families

Condition: Child Obesity
Interventions: Behavioral: FUNPALs Playgroup; Behavioral: Healthy Toddler Parent Group
Sponsor: University of Houston
Not yet recruiting
This Study in Healthy Men Tests How Different Doses of BI 1323495 Are Taken up in the Body and How Well They Are Tolerated.

Condition: Healthy
Interventions: Drug: BI 1323495; Drug: Placebo
Sponsor: Boehringer Ingelheim
Recruiting
Single-dose PK Study of Benapenem In Healthy Subjects

Condition: Healthy Subject
Interventions: Drug: Benapenem; Drug: Placebo
Sponsor: Sihuan Pharmaceutical Holdings Group Ltd.
Completed
PK/PD, Safety and Tolerability of PHP-201 Topical Eye Drop in Korean and Japanese Healthy Subjects

Condition: Healthy Volunteer
Intervention: Drug: PHP-201 0.5% ophthalmic solution (topical eye drop)
Sponsor: pH Pharma
Completed
A Study to Investigate the Effect of Rifampicin on the PK of Multiple Doses of Balovaptin In Healthy Volunteers

Condition: Healthy Volunteers
Interventions: Drug: Balovaptan; Drug: Rifampicin
Sponsor: Hoffmann-La Roche
Recruiting
A Comparative Safety and Pharmacokinetic Study of JHL1922 and Pulmozyme® in Healthy Subjects

Condition: Healthy Subjects
Interventions: Biological: JHL1922; Biological: dornase alfa
Sponsor: JHL Biotech, Inc.
Recruiting
A Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single and Multiple Doses of IONIS FXI-LRx in up to 84 Healthy Volunteers

Condition: Healthy Participants
Interventions: Drug: IONIS FXI-LRx; Drug: Placebo
Sponsor: Ionis Pharmaceuticals, Inc.
Recruiting
A Study to Investigate the Whole Body Distribution and Radiation Dosimetry of the Positron Emission Tomography Ligand Fluoride-18 (18F)-JNJ-64326067 in Healthy Participants

Condition: Healthy
Intervention: Drug: 18F-JNJ-64326067
Sponsor: Janssen Research & Development, LLC
Recruiting
A Study of Lasmiditan in Healthy Japanese and Caucasian Participants

Condition: Healthy
Interventions: Drug: Lasmiditan; Drug: Placebo
Sponsor: Eli Lilly and Company
Completed
A Study to Investigate the Effect of Itraconazole on the PK of Multiple Doses of Balovaptan in Healthy Volunteers

Condition: Healthy Volunteers
Interventions: Drug: Balovaptan; Drug: Itraconazole
Sponsor: Hoffmann-La Roche
Recruiting
Comparative Safety, Tolerability, Pharmacokinetic Study of AVT02 (100MG/ML) and Humira (100MG/ML) in Healthy Volunteers

Condition: Healthy Volunteers
Interventions: Drug: Adalimumab 100 MG/ML [Humira]; Drug: AVT02 100MG/ML
Sponsor: Alvotech Swiss AG
Active, not recruiting
Safety and PK/PD of RTA 1701 in Healthy Adults

Condition: Healthy
Interventions: Drug: Placebo oral capsule; Drug: RTA 1701 capsules
Sponsor: Reata Pharmaceuticals, Inc.
Recruiting
Phase 2 Healthy Volunteer Study to Evaluate the Ability of PRT064445 to Reverse the Effects of Several Blood Thinner Drugs on Laboratory Tests (Module 2 of 4)

Condition: Healthy Volunteers
Interventions: Combination Product: PRT064445/Rivaroxaban; Combination Product: Placebo/Rivaroxaban; Drug: Placebo
Sponsor: Portola Pharmaceuticals
Completed
Safety and Tolerability of CDX-6114 in Healthy Volunteers

Condition: Healthy
Interventions: Drug: CDX-6114; Drug: Placebo
Sponsor: Codexis Inc.
Completed
This Study in Healthy Men Tests How Different Doses of BI 1265162 Are Taken up in the Body and How Well They Are Tolerated.

Condition: Healthy
Interventions: Drug: BI 1265162; Drug: Placebo
Sponsor: Boehringer Ingelheim
Recruiting
A Study to Compare the Pharmacokinetics of JHL1149 and Bevacizumab (Avastin) in Healthy Male Volunteers

Condition: Healthy Male Subjects
Interventions: Biological: JHL1149; Biological: Bevacizumab
Sponsor: JHL Biotech, Inc.
Recruiting
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of DWP14012 After Oral Administration in Healthy Japanese, Caucasian and Korean

Condition: Healthy Volunteers
Interventions: Drug: DWP14012; Drug: Placebo
Sponsor: Daewoong Pharmaceutical Co. LTD.
Not yet recruiting
A Ph 1 Study of Epanova® in Healthy Chineses

Condition: Healthy Subjects
Intervention: Drug: Epanova
Sponsor: AstraZeneca
Completed
Studying the Starvation Effect on Androgen Metabolism in 20 Healthy Young Women and Comparison to Women With PCOS.

Condition: PCOS Disease
Intervention: Other: Androgen metabolism after starvation
Sponsor: University Hospital Inselspital, Berne
Not yet recruiting
Multiple-dose Tolerability and Pharmacokinetic Studies of Benapenem inClinical Healthy Subjects

Condition: Healthy Subject
Intervention: Drug: Banapenem
Sponsor: Sihuan Pharmaceutical Holdings Group Ltd.
Completed
The Impact of Enteral Versus Oral Protein Feeding on Muscle Protein Synthesis in Healthy Young Males and Females

Condition: Healthy
Interventions: Other: Oral Placebo; Other: Oral Protein; Other: Enteral Protein
Sponsor: University of Exeter
Recruiting
Development of Assessment Method for Driving Ability Using Driving Simulator in Healthy Volunteers #3

Condition: Healthy Participants
Interventions: Other: Road-tracking test; Other: Car-following test; Other: Harsh-braking test
Sponsors: Taisho Pharmaceutical Co., Ltd.; Nagoya University
Recruiting
VRC 610: Phase I Safety and Pharmacokinetics Study to Evaluate a Human Monoclonal Antibody (MAB) VRC-HIVMAB095-00-AB (10E8VLS) Administered Alone or Concurrently With MAB VRC- HIVMAB075-00-AB (VRC07-523LS) Via Subcutaneous Injection in Healthy Adults

Condition: Healthy Adult Immune Response
Interventions: Biological: VRC-HIVMAB95-00-AB (10E8VLS); Biological: VRC-MAB075-00-AB (VRC07-523LS)
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Suspended
Single Dose of Lu AF28996 to Healthy Young Men

Condition: Healthy
Intervention: Drug: Lu AF28996
Sponsor: H. Lundbeck A/S
Recruiting
A Pharmacokinetic Study to Assess Drug-drug Interaction Between Zanubrutinib and a Cocktail of Substrates in Healthy Subjects

Condition: Healthy Subjects
Intervention: Drug: BGB-3111 and Drug Cocktail
Sponsor: BeiGene
Completed
Investigating Memory in Healthy Subjects Using Transcranial Direct Current Stimulation

Condition: Healthy Adults
Intervention: Device: tDCS
Sponsor: The University of Texas at Dallas
Recruiting
A Single and Multiple Dose Study to Investigate Safety, Tolerability and Pharmacokinetics of JNJ-42165279 in Healthy Japanese Male Participants

Condition: Healthy
Interventions: Drug: JNJ-42165279; Drug: Placebo
Sponsor: Janssen Research & Development, LLC
Completed
Evaluate Effects of Meropenem-Vaborbactam on QT/QTc in Healthy Volunteers

Condition: Healthy
Interventions: Drug: meropenem-vaborbactam; Drug: Placebo; Drug: Moxifloxacin
Sponsors: Rempex (a wholly owned subsidiary of Melinta Therapeutics, Inc.); Biomedical Advanced Research and Development Authority
Recruiting
Bioequivalence Study on Vitamin C in Healthy Adults

Condition: Bioequivalence of Vitamin C in Healthy Adults
Interventions: Dietary Supplement: Vitafusion Power C gummy; Dietary Supplement: Nature Made vitamin C tablet
Sponsors: Church & Dwight Company, Inc.; KGK Science Inc.
Completed
Voices for Food: Food Policy Councils, Food Security and Healthy Food Choices

Conditions: Food Security; Nutritive Value
Interventions: Behavioral: Coaching and Voices for Food Kit; Behavioral: Voices for Food Kit
Sponsors: South Dakota State University; Michigan State University; Ohio State University; University of Nebraska Lincoln; Purdue University; University of Missouri-Columbia
Completed
Bioequivalence Study of Ibuprofen D, Oral Suspension, 200 mg/5ml and Nurofen®, Oral Suspension 100 mg/5 ml in Healthy Volunteers Under Fasting Conditions

Condition: Healthy
Interventions: Drug: Ibuprofen D; Drug: Nurofen® for Children
Sponsors: Pharmtechnology LLC; CRO ClinPharmInvest
Active, not recruiting
Kinetics of Blood Platelets Transfused to Healthy Subjects

Condition: Fetal and Neonatal Alloimmune Thrombocytopenia
Intervention: Other: Platelet transfusion
Sponsors: Prophylix Pharma AS; Larix A/S; Fraunhofer Institute for Molecular Biology and Applied Ecology; German Red Cross Blood Donor Service Baden, Württemberg - Hessen; Bioscientia Central Laboratory
Recruiting
An Investigational Study to Evaluate the Effect of Rifampin on the Singe Dose of Experimental Medication BMS-986224 in Healthy Participants

Condition: Healthy Participants
Interventions: Drug: Rifampin; Drug: BMS-986224
Sponsor: Bristol-Myers Squibb
Completed
Personalised Medicine in Pre-diabetes and Early Type 2 Diabetes

Conditions: Pre Diabetes; Type 2 Diabetes Mellitus
Interventions: Drug: Metformin + Healthy diet; Drug: Metformin + Personalized diet
Sponsors: Garvan Institute of Medical Research; Weizmann Institute of Science
Recruiting
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single and Multiple Doses of CC-99677 in Healthy Adult Subjects

Condition: Healthy Volunteer
Interventions: Drug: CC-99677; Other: Placebo
Sponsor: Celgene
Recruiting
A Study of LY2963016 in Healthy Chinese Participants

Condition: Healthy
Interventions: Drug: LY2963016; Drug: Insulin Glargine (Lantus)
Sponsor: Eli Lilly and Company
Not yet recruiting
2-HOBA: Multiple Dosing Study in Healthy Humans

Condition: Healthy Volunteers
Interventions: Dietary Supplement: 2-HOBA; Dietary Supplement: Placebo
Sponsors: Metabolic Technologies Inc.; Vanderbilt University; National Institute on Aging (NIA)
Recruiting
Healthy Together Program Evaluation (Phase 3)

Conditions: Health Knowledge, Attitudes, Practice; Overweight and Obesity
Intervention: Behavioral: Healthy Together
Sponsors: University of British Columbia; Public Health Agency of Canada (PHAC); The Bridge Youth and Family Services, Kelowna BC
Enrolling by invitation
Evaluate the Effect of WCK 5222 on the QT/QTc Interval in Healthy Volunteers

Condition: QT/QTc Interval in Healthy Volunteers
Interventions: Drug: WCK 5222; Drug: IV placebo matched to WCK 5222 / Moxifloxacin IV solution; Drug: Moxifloxacin 400-mg
Sponsor: Wockhardt
Completed
Healthy for Two, Healthy for You

Conditions: Weight Gain; Pregnancy Related
Interventions: Behavioral: Healthy for Two, Healthy for You; Behavioral: Health Education
Sponsors: Johns Hopkins University; Mid-Atlantic Nutrition Obesity Research Center
Completed
Randomized, Double-blind, Controlled Study to Evaluate the Effect of Concord Grape Extract on Vascular Function in Healthy Men and Women

Condition: Healthy Men and Women
Interventions: Dietary Supplement: Placebo; Dietary Supplement: Concord Grape extract 1; Dietary Supplement: Concord Grape extract 2
Sponsors: King's College London; Naturex-Dbs
Recruiting
Clinical Study on the Bioequivalence of Vitamin D in Healthy Adults

Condition: Bioequivalence of Vitamin D in Healthy Adults
Intervention: Dietary Supplement: vitamin D3
Sponsors: Church & Dwight Company, Inc.; Medical University of South Carolina
Completed
A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of JNJ-64232025 in Healthy Participants

Condition: Healthy
Interventions: Drug: JNJ-64232025 IV; Drug: JNJ-64232025 SC; Drug: Placebo
Sponsor: Janssen Research & Development, LLC
Recruiting
Variability of Impedance Pneumography Tidal Breathing Flow-volume Curves During Sleep in Healthy Children

Condition: Healthy Subjects
Intervention:
Sponsors: Revenio Research; Children's Hospital Srebrnjak
Completed
Phase 2 Healthy Volunteer Study to Evaluate the Ability of PRT064445 to Reverse the Effects of Several Blood Thinner Drugs on Laboratory Tests (Module 4 of 4)

Condition: Healthy Volunteers
Interventions: Combination Product: PRT064445/Edoxaban; Combination Product: Placebo/Edoxaban; Drug: Placebo
Sponsor: Portola Pharmaceuticals
Completed
Phase 2 Healthy Volunteer Study to Evaluate the Ability of PRT064445 to Reverse the Effects of Several Blood Thinner Drugs on Laboratory Tests (Module 3 of 4)

Condition: Healthy Volunteers
Interventions: Combination Product: PRT064445/Enoxaparin; Combination Product: Placebo/Enoxaparin; Drug: Placebo
Sponsor: Portola Pharmaceuticals
Completed
Effect of Cherry Concentrate on Brain Activation and Perfusion in Healthy Older Adults

Condition: Healthy
Interventions: Dietary Supplement: Cherry concentrate; Dietary Supplement: Placebo concentrate
Sponsor: University of Exeter
Completed
Pharmacodynamic and Safety of MBA-P01 in Healthy Male Volunteers

Condition: Healthy
Interventions: Drug: MBA-P01; Drug: BOTOX
Sponsor: Medy-Tox
Recruiting
A Study in Healthy Participants to Evaluate the Effects of Multiple Doses of JNJ-55308942 on Cytochrome P450 Substrate Activity and on the Pharmacokinetics of Levonorgestrel/Ethinyl Estradiol

Condition: Healthy
Interventions: Drug: JNJ-55308942 High Dose; Drug: JNJ-55308942 Low Dose; Drug: Levonorgestrel/Ethinyl Estradiol Fixed Dose combination (FDC); Drug: Drug Cocktail:Midazolam (2mg)/Omeprazole (20mg)/Dextromethorphan (30mg)
Sponsor: Janssen-Cilag International NV
Completed
Safety, Tolerability, Pharmacokinetics & Pharmacodynamics Study of Ropeginterferon Alfa-2b in Healthy Japanese and Caucasian Subjects

Condition: Healthy Volunteers
Intervention: Drug: ropeginterferon alfa-2b
Sponsors: PharmaEssentia Japan K.K.; PharmaEssentia
Recruiting
The Effect of an Edible Algal Extract (Ulva Lactuca) on the Component of Depression in Healthy Volunteers With Anhedonia

Condition: Anhedonia in Healthy Volunteers
Interventions: Dietary Supplement: Ulva Lactuca; Dietary Supplement: Placebo
Sponsors: CEN Biotech; CEN Nutriment; Biovet Conseil; Amadeite SAS
Completed
Effects of a Diet Based on Inulin-rich Vegetables on Gut Health and Nutritional Behaviour in Healthy Humans

Condition: Healthy
Intervention: Other: Diet based on inulin-rich vegetables
Sponsor: Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Completed
This Study is Done in Healthy Japanese Volunteers. It Looks at How Different Doses of BI 1015550 Are Taken up in the Body and How Well They Are Tolerated.

Condition: Healthy
Interventions: Drug: BI 1015550; Drug: Placebo
Sponsor: Boehringer Ingelheim
Suspended
An Investigational Study of Experimental Medication BMS-986165 in Healthy Participants to Study Electrocardiogram Effects

Conditions: Systemic Lupus Erythematosus; Healthy Participants
Interventions: Drug: BMS-986165; Drug: Moxifloxacin; Other: Placebo
Sponsor: Bristol-Myers Squibb
Completed
[18F]DASA-23 and PET Scan in Evaluating Pyruvate Kinase M2 Expression in Patients With Intracranial Tumors or Recurrent Glioblastoma and Healthy Volunteers

Conditions: Healthy Subject; Intracranial Neoplasm; Recurrent Glioblastoma
Interventions: Drug: Fluorine F 18 DASA-23; Procedure: Positron Emission Tomography
Sponsor: Sanjiv Sam Gambhir
Recruiting
Study of MN-166 (Ibudilast) Extended Release Tablet Formulations Compared With Capsules in Healthy Volunteers

Condition: Healthy Volunteers
Intervention: Drug: MN-166
Sponsor: MediciNova
Active, not recruiting
A Study to Evaluate the Efficacy of Salmon Protein Hydrolysate Powder on Energy Increase and Anti-inflammatory Modulation in Healthy Males and Females

Condition: Healthy
Intervention: Dietary Supplement: Salmon Protein Hydrolysate
Sponsors: Hofseth Biocare ASA; KGK Science Inc.
Active, not recruiting
Cardio-vascular Protective Effects of Wolfberry in Middle-aged and Older Adults

Conditions: Cardiovascular Diseases; Aging
Interventions: Other: Wolfberry; Other: Healthy diet
Sponsors: National University, Singapore; National University Hospital, Singapore; Ministry of Education, Singapore
Recruiting
Feasibility of Healthy Dads Healthy Kids Latino

Condition: Feasibility
Interventions: Behavioral: The Papás Saludables, Niños Saludables Program; Behavioral: The Papás Saludables, Niños Saludables Wait-list Control
Sponsors: Baylor College of Medicine; National Heart, Lung, and Blood Institute (NHLBI)
Recruiting
A Study to Assess the Safety, Tolerability and Pharmacokinetics of Guselkumab Following a Single Intravenous Administration in Healthy Japanese Participants

Condition: Healthy
Interventions: Drug: Guselkumab Dose 1; Drug: Guselkumab Dose 2; Drug: Guselkumab Dose 3; Drug: Placebo
Sponsor: Janssen Pharmaceutical K.K.
Recruiting
Increasing Heart Healthy Behaviors in Youth With Type 1 Diabetes

Conditions: Type1diabetes; Cardiovascular Risk Factor
Intervention: Behavioral: Heart healthy intervention
Sponsor: Joslin Diabetes Center
Recruiting
Study on the Safety and Pharmacokinetics of LM001 and Gonal-F® in Healthy Women

Condition: Infertility, Female
Interventions: Drug: Gonal-F®; Drug: LM001
Sponsor: Alphamab Jilin Co., Ltd.
Not yet recruiting
A Pharmacokinetic Study of the Effect of Itraconazole Exposure to Orvepitant in Healthy Volunteers

Condition: Pharmacokinetic Study in Healthy Male Volunteers
Interventions: Drug: Orvepitant; Drug: Itraconazole
Sponsor: Nerre Therapeutics Ltd.
Completed
Preliminary Evaluation of [68Ga]CBP8 in Healthy Individuals, Lung Cancer, and Idiopathic Pulmonary Fibrosis Patients

Conditions: Pulmonary Fibrosis; Lung Cancer
Interventions: Drug: [68Ga]CBP8; Diagnostic Test: PET Imaging
Sponsors: Massachusetts General Hospital; National Heart, Lung, and Blood Institute (NHLBI)
Recruiting
Evaluation of Pharmacokinetic Drug Drug Interaction Between PF-05221304 And PF-06865571 In Healthy Adult Subjects

Condition: Healthy
Interventions: Drug: PF-06865571 administered Day 7-14; Drug: PF-06865571 administered Day 1-14; Drug: PF-05221304 administered Day 1-14; Drug: PF-05221304 administered Day 7-14
Sponsor: Pfizer
Completed
Single Ascending Dose Study of Lu AF76432 in Healthy Young Men

Condition: Healthy
Interventions: Drug: Placebo; Drug: Lu AF76432
Sponsor: H. Lundbeck A/S
Recruiting
Assess the Safety and Tolerability of Single and Multiple Ascending Doses of Oral RO7020531 in Chinese Healthy Participants

Condition: Healthy Participants
Interventions: Drug: RO7020531; Other: Placebo
Sponsor: Hoffmann-La Roche
Recruiting
A Study to Examine the Safety, Tolerability and Biological Effects of REGN4461 in Healthy Volunteers

Condition: Healthy Volunteers
Interventions: Drug: REGN4461; Drug: Placebo
Sponsor: Regeneron Pharmaceuticals
Recruiting
Study of Changes in Retrofoveolar Choroidal Thickness During Aerobic Exercise

Conditions: Choroid Disease; Hypertension Ocular
Interventions: Other: Examination of pressures before stopping the exercise; Other: Examination of pressure during the exercise; Other: Examination of pressures after stopping the exercise
Sponsor: University Hospital, Toulouse
Not yet recruiting
A Phase 1 Study of Tegoprazan on Healthy Male Volunteers

Conditions: Pharmacodynamics; Pharmacokinetics; Healthy Male Volunteers
Interventions: Drug: Tegoprazan (C1); Drug: Treatment C: Tegoprazan (C1); Drug: Tegoprazan (C2); Drug: Esomeprazole (C2); Drug: Tegoprazan (C3)
Sponsor: CJ HealthCare Corporation
Recruiting
A Study to Evaluate the Mass Balance of 14C-Napabucasin in Healthy Adult Male Subjects

Conditions: ADME; Healthy
Intervention: Drug: napabucasin
Sponsor: Boston Biomedical, Inc
Completed
Study of the Retinal Vascularization by Laser Doppler Velocimetry Coupled With an Adaptive Optics Camera ( AO-LDV)

Conditions: Glaucoma; Retinal Vein Occlusion
Intervention: Procedure: Laser Doppler Velocimetry + Optic Adaptative Camera
Sponsor: University Hospital, Grenoble
Recruiting
Subcutaneous Elafin in Healthy Subjects

Condition: Pulmonary Arterial Hypertension
Interventions: Drug: Elafin; Drug: Placebo
Sponsors: Roham T. Zamanian; Duke University; SRI International
Not yet recruiting
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of TAK-925 Study in Sleep-Deprived Healthy Adults

Condition: Healthy Volunteers
Interventions: Drug: TAK-925; Drug: TAK-925 Placebo; Drug: Modafinil; Drug: Modafinil Placebo
Sponsor: Takeda
Active, not recruiting
Healthy Relationships and Economic Pathways

Conditions: Adolescent Relationship Abuse; Sexually Transmitted Infections; Pregnancy (Unwanted); Violence; Intentional Injury
Interventions: Behavioral: Healthy Relationships Education (HRE); Behavioral: HRE+Technology Bootcamp
Sponsors: Public Health Institute, California; American Institutes for Research
Recruiting
To Investigate Effects of a New Infant Formula in Healthy Term Chinese Infants

Condition: Healthy Infants
Interventions: Dietary Supplement: New infant formula with synbiotics; Dietary Supplement: Standard infant formula with prebiotics
Sponsors: Danone Nutricia; Nutricia Early Life Nutrition (Shanghai) Co., Ltd
Recruiting
Safety and Tolerability of SYNB1618 in Healthy Adult Volunteers and Adult Subjects With Phenylketonuria

Conditions: Phenylketonuria; Healthy
Interventions: Drug: SYNB1618; Drug: Placebo
Sponsor: Synlogic
Recruiting
A Study in Healthy Male Volunteers to Look at How the Test Medicine GLPG1690 is Taken up by the Body When Doses of Itraconazole and Voriconazole Are Given to Healthy Volunteers

Condition: Healthy
Interventions: Drug: GLPG1690; Drug: Itraconazole; Drug: Voriconazole
Sponsor: Galapagos NV
Completed
Study in Healthy Subjects to Determine the Effect of an Inhibitor on Exposure to Relacorilant and Its Metabolites

Condition: Healthy
Interventions: Drug: Relacorilant 350mg; Drug: Itraconazole; Drug: Relacorilant "higher dose"; Drug: Relacorilant "lower dose"
Sponsor: Corcept Therapeutics
Recruiting
Remote Limb Ischemic Conditioning to Enhance Learning and Muscle Strength in Healthy Young Adults

Condition: Healthy, Young Adults
Interventions: Behavioral: RLIC; Behavioral: Sham conditioning; Behavioral: Muscle strength training; Behavioral: Driving training; Behavioral: Balance training
Sponsors: Washington University School of Medicine; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting
Impact of Weekly Administration of Rifapentine and Isoniazid on Steady State Pharmacokinetics of Tenofovir Alafenamide in Healthy Volunteers (YODA)

Condition: Healthy Volunteers
Interventions: Drug: Vemlidy (tenofivir alafenamide); Drug: Priftin (rifapentine); Drug: Isoniazid; Dietary Supplement: Pyridoxine
Sponsor: National Institutes of Health Clinical Center (CC)
Recruiting
A Study to Assess the Absorption of Apixaban (BMS-562247) Sprinkle Capsules Compared With Tablets in Healthy Volunteers

Condition: Healthy Volunteers
Interventions: Drug: Apixaban sprinkle capsules; Drug: Apixaban tablets
Sponsor: Bristol-Myers Squibb
Completed
Effects of the Physical Fitness on Serum Klotho Levels in Healthy Population

Condition: Healthy Population
Interventions: Other: Strength exercise; Other: Aerobic exercise
Sponsor: Universidad Europea de Madrid
Enrolling by invitation
Acute Effect of a Standardized Botanical Blend Rich in Polyphenols on Cognitive Functions in Healthy Students

Condition: Healthy
Interventions: Dietary Supplement: SBRP; Dietary Supplement: PLACEBO
Sponsors: Activ'inside; CIC SANPSY (USR CNRS 3413), Hôpital Pellegrin, Bordeaux, FRANCE; Hospital St André, Bordeaux, FRANCE
Recruiting
Safety and Immunogenicity of MT-5625 in Healthy Adults, Toddlers and Infants

Condition: Healthy
Interventions: Biological: MT-5625 low dose; Biological: MT-5625 middle dose; Biological: MT-5625 high dose; Biological: Rotarix; Biological: Placebo
Sponsor: Mitsubishi Tanabe Pharma Corporation
Recruiting
A Study of Lanabecestat in Healthy Female Participants Taking Oral Contraceptive

Condition: Healthy
Interventions: Drug: Lanabecestat; Drug: Oral Contraceptive
Sponsors: Eli Lilly and Company; AstraZeneca
Withdrawn
A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of RO7062931 in Healthy Chinese Volunteers.

Condition: Healthy Participants
Interventions: Drug: RO7062931; Drug: Placebo
Sponsor: Hoffmann-La Roche
Recruiting
[Tc-99m]-RPI-087 as an Imaging Marker in Osteoarthritis of the Knee Compared to Healthy Volunteers

Conditions: Healthy; Osteo Arthritis Knee
Intervention: Drug: [Tc-99m]-RPI-T-087 Injection
Sponsor: Reiley Pharmaceuticals Inc.
Recruiting
This Study in Healthy Men and Women Tests How the Body Takes up BI 409306

Condition: Healthy
Interventions: Drug: BI 409306 (C-13/N-15); Drug: BI 409306
Sponsor: Boehringer Ingelheim
Completed
A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of OP-101 After Intravenous Administration in Healthy Volunteers

Condition: Healthy
Intervention: Drug: OP-101
Sponsor: Orpheris, Inc.
Completed
A Trial to Evaluate the Effect of Itraconazole (ITZ), a CYP3A4 Inhibitor, on the Pharmacokinetics of the Soluble Guanylate Cyclase Inhibitor Praliciguat (IW-1973) in Healthy Volunteers

Condition: Healthy
Interventions: Drug: IW-1973; Drug: Itraconazole
Sponsor: Ironwood Pharmaceuticals, Inc.
Completed
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK), and Pharmacodynamics (PD) of Single and Multiple Oral Dose of TAK-418 in Healthy Female Participants

Condition: Healthy Volunteers
Interventions: Drug: TAK-418; Drug: TAK-418 Matching Placebo
Sponsor: Takeda
Recruiting
A Study to Determine the Bioequivalence of Alogliptin and Pioglitazone When Administered as Individual Tablets and as Fixed-Dose Combination (FDC)-SYR-322-4833 BL Tablets to Healthy Russian Participants

Condition: Healthy Volunteers
Interventions: Drug: Alogliptin; Drug: Pioglitazone; Drug: SYR-322-4833 BL
Sponsor: Takeda
Completed
A Study to Evaluate Safety and Immunogenicity of the ExPEC4V Clinical Trial Material After a Single Intramuscular Dose and a Second Dose 6 Months Later in Healthy Participants Aged 18 Years and Older

Condition: Healthy
Interventions: Biological: ExPEC4V; Biological: Placebo
Sponsor: Janssen Research & Development, LLC
Active, not recruiting
A Study to Evaluate the Mass Balance, Pharmacokinetics (PK), Metabolism and Excretion of TAK-954 Containing Microtracer ([14C]-TAK-954) in Healthy Male Participants

Condition: Healthy Volunteers
Intervention: Drug: [14C]-TAK-954
Sponsor: Millennium Pharmaceuticals, Inc.
Completed
Gamma Scintigraphy Study to Investigate Tablet Disintegration in Healthy Volunteers.

Condition: Healthy Subjects
Interventions: Drug: Ibuprofen lysine; Drug: Ibuprofen Sodium; Drug: Ibuprofen; Drug: Ibuprofen (Nurofen); Drug: Ibuprofen (Wockhardt)
Sponsor: Reckitt Benckiser Healthcare (UK) Limited
Terminated
The Effect of Itraconazole on BCT197 Exposure in Healthy Male Participants

Condition: Interaction
Interventions: Drug: BCT197; Drug: Itraconazole 200 mg
Sponsor: Mereo BioPharma
Completed
Clinical Trial to Assess the Safety and Pharmacokinetics of RDG-17012 Capsule and Pradaxa® Capsule in Healthy Male Volunteers

Condition: Healthy
Interventions: Drug: RDG-17012 Capsule; Drug: Dabigatran Etexilate Mesylate 150 MG Oral Capsule
Sponsor: Huons Co.,Ltd.
Active, not recruiting
A Study In Healthy Male Volunteers Designed To Investigate How A Radiolabelled Medicine Is Broken Down And Removed From The Body

Condition: Healthy Subjects
Intervention: Drug: pracinostat
Sponsors: Helsinn Healthcare SA; Quotient Sciences
Enrolling by invitation
A Clinical Study to Assess the Effect of Clopidogrel on the Pharmacokinetics of Selexipag and Its Active Metabolite in Healthy Male Subjects

Condition: Healthy Subjects
Interventions: Drug: Selexipag; Drug: Clopidogrel
Sponsor: Actelion
Completed
A Study to Evaluate the Effects of Single-dose Seltorexant on Electrocardiogram Intervals in Healthy Adult Participants

Condition: Healthy
Interventions: Drug: Seltorexant; Other: Placebo Matched to Seltorexant; Other: Placebo Matched to Moxifloxacin; Drug: Moxifloxacin Dose 1
Sponsor: Janssen Research & Development, LLC
Completed
A Mass Balance Study of LCB01-0371 After a Single Oral LCB01-0371 Dose With a [14C]LCB01-0371-microtrace

Condition: Healthy
Intervention: Drug: LCB01-0371 dose with a [14C]-LCB01-0371-tracer dose
Sponsor: LegoChem Biosciences, Inc
Not yet recruiting
Study to Evaluate the Safety, Tolerability, PK, and PD of PB2452 in Healthy Volunteers

Condition: Healthy
Interventions: Drug: PB2452 Infusion; Drug: Placebo - Sodium Chloride; Drug: Ticagrelor Oral Tablet - Pre-Treatment; Drug: Ticagrelor Oral Tablet - Pre-Treatment and Post-Treatment
Sponsor: PhaseBio Pharmaceuticals Inc.
Completed
A Single Dose Crossover Study In Healthy Subjects To Evaluate Different Formulations Of PF-06882961

Condition: Healthy Subjects
Interventions: Drug: PF-06882961 Immediate Release Tablet; Drug: PF-06882961 Controlled Release Tablet (long); Drug: PF-06882961 Controlled Release Tablet (short); Drug: PF-06882961 Immediate Release Solution
Sponsor: Pfizer
Completed
Safety of Single Intravenous Administration of S95010 in Human Healthy Volunteers

Condition: Cardiovascular Diseases
Interventions: Drug: S 95010; Other: Placebo
Sponsors: Institut de Recherches Internationales Servier; ADIR Association
Recruiting
A Multiple Dose Study of BAY1834845 in Healthy Male Subjects and in Patients With Rheumatoid Arthritis (RA) or Psoriasis

Condition: Healthy Volunteers
Interventions: Drug: BAY1834845; Other: Matching Placebo; Drug: Midazolam
Sponsor: Bayer
Recruiting
A Study to Evaluate the Safety and Pharmacokinetics (PK, the Measure of How the Human Body Processes a Substance) of ETX0282 When Administered Orally to Healthy Participants

Condition: Healthy Volunteers
Interventions: Drug: ETX0282; Drug: Cefpodoxime proxetil; Drug: Placebo
Sponsor: Entasis Therapeutics
Recruiting
"The Effects of Clinical Pilates Exercises on Cognitive Functions and Speed of Movement in Healthy Young Adults"

Condition: Healthy
Interventions: Other: Clinic Pilates Group; Other: Aerobic Exercise Group; Other: Control Group
Sponsors: Biruni University; Istanbul University
Recruiting
Study of ITI-214 in Healthy Volunteers to Determine CNS Engagement

Condition: Healthy Volunteers
Interventions: Drug: ITI-214; Drug: Placebo
Sponsors: Intra-Cellular Therapies, Inc.; Laureate Institute for Brain Research, Inc.
Recruiting
VitalFlow Healthy Volunteer Study

Condition: Normal Subject / Healthy Volunteers
Intervention: Device: magnetic facial nerve stimulation
Sponsors: Nervive, Inc.; Centro Nacional de Investigacion en Imagenologia e Instrumentacion Medica (CI3M)
Completed
Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of After Administrations of DWP14012 Alone and Combinations of DWP14012, Clarithromycin and Amoxicillin in Healthy Male Subjects

Condition: Healthy
Interventions: Drug: DWP14012 Amg; Drug: DWP14012 Bmg; Drug: Clarithromycin; Drug: Amoxicillin; Drug: Lansoprazole
Sponsor: Daewoong Pharmaceutical Co. LTD.
Recruiting
Dual Site-Dual Channel Non-invasive Brain Stimulation for Motor Function in Healthy Subjects

Condition: Healthy
Interventions: Device: M1 stimulation; Device: PMC stimulation; Device: Sham stimulation
Sponsor: Samsung Medical Center
Recruiting
Dual Site-Dual Channel Non-invasive Brain Stimulation for Language and Cognitive Function in Healthy Subjects

Condition: Healthy
Interventions: Device: IFG stimulation; Device: DLPFC stimulation; Device: Sham stimulation
Sponsor: Samsung Medical Center
Recruiting
Pharmacokinetic Study of Lansoprazole Capsules in Healthy Chinese Volunteer

Conditions: Effect of Drugs; Safety Issues
Intervention: Drug: Lansoprazole capsules
Sponsors: First Affiliated Hospital of Zhejiang University; Beijing Xuze Medical Technology Co., LTD.
Recruiting
Beta-hCG Test Reference Range Determination

Condition: Healthy
Intervention:
Sponsor: Response Biomedical Corp.
Enrolling by invitation
Healthy Heart Score Intervention In the Primary Care Setting

Condition: Cardiovascular Diseases
Intervention: Behavioral: Healthy Heart Score
Sponsors: Ohio University; OhioHealth
Recruiting
Study of Lemborexant-Alcohol Interaction in Healthy Subjects

Condition: Healthy Subjects
Interventions: Drug: Lemborexant; Drug: Alcohol; Drug: Placebo
Sponsors: Eisai Inc.; Purdue Pharma LP
Completed
This Study in Healthy Men Tests How the Body Takes up BI 1467335

Condition: Healthy
Interventions: Drug: BI 1467335; Drug: BI 1467335 (C-14) intravenous solution
Sponsor: Boehringer Ingelheim
Completed
Pharmacokinetic, Safety and Immunogenicity Phase I Study of HLX04 Versus Avastin® in Healthy Male Subjects

Condition: Healthy Male Subjects
Interventions: Drug: HLX04; Drug: US-Avastin®; Drug: EU-Avastin®; Drug: CN-Avastin®
Sponsor: Shanghai Henlius Biotech
Completed
A Study to Evaluate the Pharmacokinetics (PK), Safety and Tolerability of TAK-788 Followed by Evaluation of the Effects of a Low-Fat Meal on TAK-788 PK in Healthy Participants

Condition: Healthy Volunteers
Interventions: Drug: TAK-788; Drug: Placebo
Sponsor: Millennium Pharmaceuticals, Inc.
Active, not recruiting
This Study in Healthy Volunteers Determines the Amount of BI 730460 in the Blood When Taken as Tablet. It Looks at How Different Doses of BI 730460 Are Taken up in the Body and How Well They Are Tolerated. The Study Also Tests How Food Influences the Amount of BI 730460 in the Blood.

Condition: Healthy
Interventions: Drug: BI 730460; Drug: Placebo
Sponsor: Boehringer Ingelheim
Not yet recruiting
It's Your Game: An Innovative Approach to Preventing Teen Dating Violence

Conditions: Adolescent Behavior; Interpersonal Relationships; Domestic Violence; Physical Violence
Intervention: Behavioral: Me & You: Building Healthy Relationships
Sponsor: The University of Texas Health Science Center, Houston
Completed
First-In-Human Study of BBT-401-1S Following Single and Multiple Ascending Doses in Healthy Volunteers

Condition: Ulcerative Colitis
Interventions: Drug: BBT-401-1S, Single dose; Drug: BBT-401-1S, Multiple doses; Drug: Placebo
Sponsors: Bridge Biotherapeutics, Inc.; KCRN Research, LLC
Recruiting
A Study of ACE-2494 in Healthy Subjects

Condition: Healthy Volunteers
Intervention: Drug: ACE-2494 or placebo
Sponsor: Acceleron Pharma, Inc.
Recruiting
Safety and Pharmacokinetics of a Human Monoclonal Antibody, VRC-EBOMAB092-00-AB (MAb114), Administered Intravenously to Healthy Adults

Condition: Healthy Adult Immune Responses to Vaccine
Intervention: Biological: VRC-EBOMAB092-00-AB (MAb114)
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Active, not recruiting
Sleep and Nocturnal Enuresis: Ambulatory Polysomnographic Study

Conditions: Nocturnal Enuresis; Polysomnography
Intervention: Device: Polysomnography (Full sleep registration)
Sponsor: University of Aarhus
Recruiting
Assessment of the Biodistribution and Safety of [18F]MNI-958 in Healthy Subjects

Condition: Healthy Volunteers
Intervention: Drug: [18F]MNI-958
Sponsor: Invicro
Completed
A 6-Week Study to Evaluate Photoallergic Skin Reaction of CCP-020 (Diacerein 1%) in Healthy Subjects

Condition: Healthy
Intervention: Drug: CCP-020 Diacerein 1% topical ointment and vehicle ointment
Sponsor: Castle Creek Pharmaceuticals, LLC
Completed
Study to Evaluate the Respiratory Safety of Lemborexant in Adult and Elderly Healthy Subjects and Adult and Elderly Subjects With Mild Obstructive Sleep Apnea

Conditions: Obstructive Sleep Apnea; Healthy Subjects
Interventions: Drug: Placebo; Drug: Lemborexant 10 mg; Drug: Lemborexant 25 mg
Sponsors: Eisai Inc.; Purdue Pharma LP
Completed
A 4-Day Study to Evaluate Phototoxicity of CCP-020 (Diacerein 1%) in Healthy Subjects

Condition: Healthy
Interventions: Drug: CCP-020 Diacerein 1% topical ointment; Drug: Vehicle
Sponsor: Castle Creek Pharmaceuticals, LLC
Completed
A 21-Day Study to Evaluate the Skin Irritation Potential of CCP-020 (Diacerein 1%) Topical Ointment in Healthy Subjects Using a Cumulative Irritant Patch Test Design

Condition: Healthy
Intervention: Drug: Diacerein 1% topical ointment and Vehicle
Sponsor: Castle Creek Pharmaceuticals, LLC
Completed
cAd3-Marburg Vaccine in Healthy Adults

Condition: Marburg Virus Disease
Intervention: Biological: cAd3-Marburg vaccine
Sponsors: National Institute of Allergy and Infectious Diseases (NIAID); US Military HIV Research Program
Not yet recruiting
A Study to Evaluate the Sensitizing Potential of CCP-020 (Diacerein 1%) Topical Ointment in Healthy Subjects Using a Repeat Insult Patch Test Design

Condition: Skin Pigment
Intervention: Drug: CCP-020 (Diacerein 1% Ointment)
Sponsor: Castle Creek Pharmaceuticals, LLC
Completed
A Crossover Study to Assess the Drug-drug Interaction of Acid Reducing Agent(s) on the Pharmacokinetics of a Single Oral Dose of Lumicitabine (JNJ-64041575) in Healthy Adult Participants

Condition: Healthy
Interventions: Drug: Lumicitabine; Drug: Lansoprazole; Drug: Ranitidine
Sponsor: Janssen Research & Development, LLC
Terminated
Investigating Transcranial Direct Current Stimulation (tDCS) in Accelerating Learning in a Healthy Older Population

Condition: Associative Memory in Healthy Subjects
Interventions: Device: Active tDCS; Device: Sham tDCS
Sponsor: The University of Texas at Dallas
Active, not recruiting
A First-in-human Phase 1 Study of CP1050

Condition: Healthy Subjects
Intervention: Drug: CP1050 or Placebo
Sponsor: Curadim Pharma Co., Ltd.
Enrolling by invitation
A Study to Assess the Food Effect on Bioavailability of Metformin/Gliclazide in Healthy Participants

Condition: Healthy
Intervention: Drug: Metformin/Gliclazide Fixed Combination
Sponsor: Merck KGaA
Completed
Bioequivalence and Drug - Drug Interaction Study of Metformin/Gliclazide in Healthy Participants

Condition: Healthy
Interventions: Drug: Metformin/Gliclazide Fixed Combination; Drug: Metformin; Drug: Gliclazide
Sponsor: Merck KGaA
Completed
A Study of Lasmiditan on the Heart in Healthy Participants

Condition: Healthy
Interventions: Drug: Lasmiditan; Drug: Moxifloxacin; Drug: Placebo for Lasmiditan; Drug: Placebo for Moxifloxacin
Sponsors: Eli Lilly and Company; CoLucid Pharmaceuticals
Completed
Identification of EMT Indicators in Healthy and Periodontally Diseased Gingival Samples

Condition: Chronic Periodontitis
Intervention: Procedure: Gingival tissue samples will be harvested
Sponsor: Cairo University
Not yet recruiting
Pharmacokinetics, Safety and Tolerability of Treprostinil Inhalation Powder in Healthy Normal Volunteers

Condition: Pulmonary Arterial Hypertension
Intervention: Drug: Treprostinil Inhalation Powder
Sponsor: Mannkind Corporation
Recruiting
Safety, Tolerability and Pharmacokinetic Profiles of MOTREM (LR12) in Healthy Male Subjects

Condition: Healthy Subjects
Interventions: Drug: nangibotide; Drug: Placebo
Sponsors: Inotrem; Richmond Pharmacology Limited
Completed
Study to Determine the Single and Repeat Dose Pharmacokinetics, Food Effect, Proton Pump Inhibitor (PPI) Drug Interaction, Safety and Tolerability of Oral Prototype Formulations of BOS172767 in Healthy Subjects

Condition: Healthy Subjects
Interventions: Drug: BOS172767 tablets; Drug: BOS172767 liquid capsules; Drug: BOS172767 micronized capsules; Drug: BOS172767 immediate release capsules; Drug: BOS172767 matching placebo capsules; Drug: BOS172767 matching placebo tablets; Drug: Rabeprazole
Sponsor: Boston Pharmaceuticals
Recruiting
A Study to Test the Safety, Pharmacokinetics, and Pharmacodynamics of Single Ascending Intravenous Doses of UCB0107 in Healthy Male Subjects

Condition: Healthy Male Volunteers
Interventions: Drug: UCB0107; Other: Placebo
Sponsor: UCB Biopharma S.P.R.L.
Recruiting
SHE Tribe: An Intervention to Improve Health Behavior Among Women in Underserved Communities

Condition: Health Promotion
Intervention: Behavioral: SHE Tribe
Sponsors: University of North Texas Health Science Center; YMCA of Metropolitan Fort Worth; National Institute on Minority Health and Health Disparities (NIMHD)
Recruiting
A Study to Evaluate the Efficacy of the Investigational Products on Complete Spontaneous Bowel Movements in Participants Who Normally Have ≤ 3 Complete Spontaneous Bowel Movements Per Week But Are Otherwise Healthy

Conditions: Functional Constipation; Healthy
Interventions: Dietary Supplement: Actazin (green kiwi powder) High Dose; Dietary Supplement: Actazin (green kiwi powder) Low Dose; Dietary Supplement: Control Formula (Actazin green kiwi powder + PreticX prebiotic); Dietary Supplement: Livaux (gold kiwi powder) High Dose; Dietary Supplement: Livaux (gold kiwi powder) Low Dose; Dietary Supplement: Placebo (microcrystalline cellulose)
Sponsors: AIDP, Inc.; KGK Science Inc.
Recruiting
A Study of Lasmiditan on Simulated Driving Performance in Healthy Participants

Condition: Healthy
Interventions: Drug: Lasmiditan; Drug: Placebo; Drug: Diphenhydramine
Sponsor: Eli Lilly and Company
Completed
A Bioequivalence Study of Losartan Potassium Tablets (Containing Losartan Potassium 100 mg) in Normal, Healthy, Adults Under Fasting Conditions

Condition: Healthy
Interventions: Drug: Cozaar 100mg Tablet; Drug: Losartan potassium 100mg
Sponsors: Pharmtechnology LLC; Reliance Life Sciences Private Limited
Completed
A Phase I Study of LuoXin Innovate (LXI-15028) in Healthy Chinese Subjects to Evaluate the Pharmacokinetics, Safety and Tolerability.

Condition: Healthy
Interventions: Drug: LXI-15028 50mg; Drug: LXI-15028 100mg; Drug: LXI-15028 200mg; Drug: Placebo
Sponsor: Shandong Luoxin Pharmaceutical Group Stock Co., Ltd.
Completed
Study in Healthy Subjects to Determine the Effect of Relacorilant on Exposure to Probe Substrates for Cytochrome P450s

Condition: Healthy
Interventions: Drug: Midazolam hydrochloride; Drug: Metoprolol tartrate; Drug: Pioglitazone hydrochloride; Drug: Tolbutamide; Drug: Omeprazole; Drug: Relacorilant
Sponsor: Corcept Therapeutics
Completed
IV Dose Study to Assess the Safety, Tolerability, PK, PD and Immunogenicity of ARGX-113 in Healthy Volunteers

Condition: Healthy Volunteers
Interventions: Biological: ARGX-113; Biological: Placebo
Sponsor: argenx BVBA
Completed
Safety, Efficacy of FFP From Healthy Donors to AmeliorateFrailty and Enhance Immune Function in Older Individuals

Condition: Frailty
Intervention: Drug: GMFFP
Sponsor: Dipnarine Maharaj
Enrolling by invitation
A Study of LY3074828 in Healthy Participants

Condition: Healthy
Intervention: Biological: LY3074828
Sponsor: Eli Lilly and Company
Completed
B-Fit Intervention to Improve Brain Health

Conditions: Health Behavior; Aging
Interventions: Behavioral: Problem-solving; Behavioral: Education
Sponsor: Washington State University
Recruiting
A Study to Assess the Safety, Tolerability, and Pharmacokinetics of E2730 in Healthy Participants

Condition: Healthy Participants
Interventions: Drug: E2730; Drug: Placebo
Sponsor: Eisai Inc.
Recruiting
Determination of Autonomic Responses to the Exposure of Low Energy Electromagnetic Fields With Frequency Modulation in Patients With Advanced Hepatocellular Carcinoma and Healthy Individuals.

Condition: Hepatocellular Carcinoma
Intervention: Other: measuring hemodynamic parameters heart beat to heart beat during single-frequency exposure
Sponsor: Hospital Sirio-Libanes
Recruiting
Effects of Exogenous Ketones in Healthy Young Adults

Condition: Healthy Young Adults
Intervention: Dietary Supplement: Ketone Salts
Sponsors: Augusta University; Funding source: Pruvit Ventures, Inc
Completed
Multiple Breath Nitrogen Washout in Healthy Volunteers

Condition: Healthy
Intervention: Procedure: Multiple breath nitrogen washout
Sponsor: Hospices Civils de Lyon
Not yet recruiting
Study to Assess the Pharmacokinetic Drug-Drug Interactions of Lemborexant When Coadministered With an Oral Contraceptive, Famotidine, or Fluconazole in Healthy Subjects

Condition: Healthy Subjects
Interventions: Drug: lemborexant; Drug: Loestrin; Drug: famotidine; Drug: fluconazole
Sponsors: Eisai Inc.; Purdue Pharma LP
Completed
A Single Oral Dose Study to Evaluate Four Different Formulations of AZD9977 and the Effect of Food in Healthy Male Subjects

Condition: Healthy Volunteers
Interventions: Drug: AZD9977 Oral suspension (reference); Drug: AZD9977 capsule; Drug: AZD9977 ER capsule (fastvrate); Drug: AZD9977 ER capsule (Int. rate)
Sponsors: AstraZeneca; Parexel
Completed
Metabolic and Physiological Changes During Minor Orthopaedic Surgery in Otherwise Healthy Patients

Conditions: Metabolomics; Anesthesia, General; Oxygen
Intervention:
Sponsor: Aalborg Universitetshospital
Completed
Single-dose Study of [14C]PF-05221304 Metabolism and Excretion in Healthy Adult Male Subjects

Condition: Healthy
Intervention: Drug: [14C]PF-05221304
Sponsor: Pfizer
Completed
An Open Label, Single-Dose Study of 14C-NW-3509 in Healthy Male Subjects

Condition: Healthy
Intervention: Drug: Evenamide
Sponsor: Newron Pharmaceuticals SPA
Recruiting
To Evaluate the Safety, Tolerability and Pharmacokinetics of K0706 in Plasma and Cerebrospinal Fluid in Healthy Volunteers

Condition: Healthy
Intervention: Drug: K0706
Sponsor: Sun Pharma Advanced Research Company Limited
Recruiting
A Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, Immunogenicity of N-Rephasin® SAL200 in Healthy Male Volunteers

Conditions: Healthy Volunteers; Anti-Bacterial Agents; Methicillin-Resistant Staphylococcus Aureus; Methicillin-Sensitive Staphylococcus Aureus Infection
Interventions: Biological: N-Rephasin® SAL200; Other: INT200-Placebo
Sponsor: Intron Biotechnology, Inc.
Recruiting
A Food Effect Study in Healthy Volunteers With PT2977 Tablets

Condition: Healthy
Intervention: Drug: PT2977
Sponsor: Peloton Therapeutics, Inc.
Not yet recruiting
OSS-IRM: Optimization of MRI Sequences in Healthy Volunteers

Condition: Healthy
Intervention: Device: MRI data acquiring in healthy volunteers
Sponsor: Rennes University Hospital
Recruiting
A Bioavailability Study of MIV-711 Oral Formulations in Healthy Volunteers

Condition: Healthy
Intervention: Drug: MIV-711
Sponsor: Medivir
Completed
A Study to Determine the Absorption, Metabolism, and Excretion of [14C]-E6007 After a Single Oral Administration in Healthy Male Participants

Condition: Healthy Male Participants
Intervention: Drug: [14C]-E6007
Sponsor: EA Pharma Co., Ltd.
Completed
Differential Metabolic Signature of Stroke Patients Undergoing Thrombolysis

Condition: Stroke, Ischemic
Intervention:
Sponsor: Cambridge University Hospitals NHS Foundation Trust
Not yet recruiting
Relacorilant Food Effect Study in Healthy Subjects

Conditions: Healthy; Food-drug Interaction
Interventions: Drug: Relacorilant Fasted; Drug: Relacorilant with a high fat breakfast; Drug: Relacorilant with a moderate breakfast
Sponsor: Corcept Therapeutics
Completed
A Crossover Study to Assess the Effect of Intravenous Infusion of Piperacillin/Tazobactam on the Pharmacokinetics of Orally Administered Lumicitabine (JNJ-64041575) in Healthy Adult Participants

Condition: Healthy
Interventions: Drug: Lumicitabine; Drug: Piperacillin/Tazobactam
Sponsor: Janssen Research & Development, LLC
Completed
Training on Unstable Surfaces and Effects on the Balance of Healthy Young People

Condition: Healthy
Interventions: Other: Unstable; Other: Stable
Sponsor: University of Valencia
Completed
Single-dose Novel Selective alpha2c Antagonist Pharmaco-MRI Study in Healthy Volunteers

Condition: Healthy Volunteer
Interventions: Drug: ORM-12741; Drug: Placebo
Sponsors: University of Cape Town; Orion Corporation, Orion Pharma; University of Oxford
Recruiting
A Study of Orally Administered JNJ-440 to Evaluate the Safety, Tolerability, and Pharmacokinetics After Single Ascending Doses Including Food Effect Evaluation; After Multi-Day Dosing in Healthy Participants; and After Multiple (Ascending) Doses in Participants With Chronic Hepatitis B

Condition: Chronic Hepatitis B
Interventions: Drug: JNJ-440; Drug: Placebo
Sponsor: Alios Biopharma Inc.
Recruiting
A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ESN364 in Healthy Japanese Male and Pre- and Post-menopausal Female Subjects

Condition: Healthy Subjects
Interventions: Drug: ESN364; Drug: Placebo
Sponsor: Astellas Pharma Inc
Completed
The Effects of Castration on the Pharmacokinetics of Zolpidem After Single Dose Administration In Men With Prostate Cancer Undergoing Androgen Deprivation Therapy Compared to Normal Healthy Females

Condition: Prostatic Neoplasms
Intervention: Drug: Zolpidem
Sponsor: National Cancer Institute (NCI)
Recruiting
A Study to Evaluate the Relative Oral Bioavailability of Seltorexant (JNJ-42847922) After Administration of 3 Different Formulations in Healthy Participants Under Fasted and Semi-fasted Conditions

Condition: Healthy
Interventions: Drug: Seltorexant 40 mg; Drug: Seltorexant 20 mg
Sponsor: Janssen Research & Development, LLC
Completed
The Impact of Workplace Food and Beverage Choices on Health and Wellness

Condition: Health and Wellness
Intervention: Other: Healthy Beverage Initiative
Sponsors: California Pacific Medical Center Research Institute; Laura and John Arnold Foundation; University of California, San Francisco; Elissa Epel, PhD; Laura Schmidt, PhD, MSW, MPH
Enrolling by invitation
Multiple-ascending Dose Study to Assess the Safety, Tolerability and Pharmacokinetics of AZD9977 in Healthy Male Subjects

Condition: Healthy Volunteers
Interventions: Drug: AZD9977; Other: Placebo
Sponsors: AstraZeneca; Parexel
Completed
ProbGut: Probiotics on the Healthy Gut Microbiota

Condition: Healthy
Intervention: Other: Probiotic yogurt drink
Sponsors: McMaster University; Mitacs
Active, not recruiting
A Two-Part Phase 1 Study to Investigate the Safety and Tolerability of Supratherapeutic Dose of Zanubrutinib and Effect of Zanubrutinib on Cardiac Repolarization in Healthy Subjects

Condition: Healthy Volunteers
Interventions: Drug: BGB-3111; Drug: Placebo; Drug: Moxifloxacin
Sponsor: BeiGene
Completed
The Effect of Losartan on Emotional Processing in Healthy Volunteers

Condition: Healthy Volunteers
Interventions: Drug: Losartan; Other: Placebo
Sponsor: University of Oxford
Completed
A Study to Investigate the Interaction Between ACT-246475 and Clopidogrel, Prasugrel, and Ticagrelor in Healthy Subjects

Condition: Healthy
Interventions: Drug: ACT-246475; Drug: Clopidogrel; Drug: Prasugrel; Drug: Placebo; Drug: Ticagrelor
Sponsor: Idorsia Pharmaceuticals Ltd.
Recruiting
A Study of Experimental Medication BMS-986278 Given to Healthy Participants

Condition: Healthy Participants
Interventions: Drug: BMS-986278; Other: Placebo
Sponsor: Bristol-Myers Squibb
Recruiting
Enhancing Independence Using Group-based Community Interventions for Healthy AGing in Elders: the ENGAGE Pilot Study

Condition: Mobility Limitation
Interventions: Other: Physical Activity Intervention; Other: Healthy Aging Intervention
Sponsors: Tufts University; Somerville Council on Aging
Completed
Compare the Effects of Agility and Cycling Exercise Training on Mobility and Balance in PD and Healthy Old Adults

Conditions: Healthy; Movement Disorders; Parkinson Disease; Condition
Intervention: Other: Rehabilitation
Sponsors: Somogy Megyei Kaposi Mór Teaching Hospital; University of Groningen
Active, not recruiting
A Study to Evaluate the Denosumab in Healthy Adults

Condition: Healthy Adults
Interventions: Drug: LY06006; Drug: Placebos
Sponsors: Luye Pharma Group Ltd.; Shangdong Boan Biotechnology Co Ltd
Recruiting
Harvest of CTCs From MBC Patients Using the Parsortix™ PC1 System

Conditions: Healthy Volunteers; Breast Cancer, Metastatic
Intervention: Diagnostic Test: Blood draw
Sponsor: Angle plc
Recruiting
Probiotics and Examination-related Stress in Healthy Medical Students

Conditions: Healthy; Stress-related Problem; Anxiety
Interventions: Dietary Supplement: Lactobacillus rhamnosus GG (ATCC 53103); Dietary Supplement: Saccharomyces boulardii (CNCM I-1079); Dietary Supplement: Placebo
Sponsor: Medical Universtity of Lodz
Completed
Pharmacokinetic Study of Perampanel in Chinese Healthy Subjects

Condition: Healthy Subjects
Intervention: Drug: Perampanel
Sponsor: Eisai Co., Ltd.
Completed
Phase I/II Clinical Trial of NPF-08 in Healthy Volunteers

Condition: Healthy Volunteers
Intervention: Drug: NPF-08
Sponsor: Nihon Pharmaceutical Co., Ltd
Completed
A Study to Evaluate the Food-Effect of H3B-6527

Condition: Healthy Participants
Intervention: Drug: H3B-6527
Sponsors: Eisai Inc.; H3 Biomedicine Inc.
Completed
Study of Rotatory Vestibular Tests in Major Depression Patients and Healthy Control Subjects.

Conditions: Depression; Vestibular Disorder
Intervention: Diagnostic Test: Rotatory vestibular test
Sponsors: Vest Brain,Centro de Estudios Neurovestibulares; Centro de Medicina Aeroespacial.
Completed
Federal Evaluation of Selected Programs for Expectant and Parenting Youth

Conditions: Teen Pregnancy Prevention; Contraceptive Usage
Intervention: Behavioral: Healthy Families, Healthy Futures
Sponsors: Mathematica Policy Research, Inc.; The Office of Adolescent Health, HHS; Decision Information Resources, Inc.
Active, not recruiting
Clinical Trial to Explore the the Amyloid Beta Draining Effect of Thiethylperazine (TEP) in Subjects With Newly Diagnosed Early-to-mild Dementia Due to Alzheimer's Disease (AD) in Comparison to Healthy Volunteers

Condition: Alzheimer Disease
Intervention: Drug: TEP
Sponsor: Immungenetics AG
Recruiting
Oesophageal Acid Exposure in Healthy Subjects Over 96 Hours

Condition: Gastroesophageal Reflux
Intervention: Device: Bravo
Sponsor: Guy's and St Thomas' NHS Foundation Trust
Not yet recruiting
A Study to Evaluate the Safety of K-755 in Healthy Volunteers

Condition: Healthy
Interventions: Drug: K-755 Part A (SAD); Drug: Placebo Part A (SAD); Drug: K-755 Part B (MAD); Drug: Placebo Part B (MAD); Drug: K-755 Part C (FE)
Sponsor: Kowa Company, Ltd.
Recruiting
Healthy Lifestyle Intervention for High-Risk Minority Pregnant Women

Conditions: Emotional Disturbances; Depression; Pregnancy Late; Post-Partum Depression; Anxiety; Nutritional Deficiency
Intervention: Behavioral: COPE-P
Sponsors: Ohio State University; National Institutes of Health (NIH); New York University; Jacobi Medical Center; Boston College; University of Arizona; Drexel University; National Institute on Minority Health and Health Disparities (NIMHD)
Recruiting
Development of Assessment Method for Driving Ability Using Driving Simulator in Healthy Volunteers #2

Condition: Healthy Participants
Interventions: Other: Road-tracking test; Other: Car-following test; Other: Harsh-braking test
Sponsors: Taisho Pharmaceutical Co., Ltd.; Nagoya University
Completed
A Study to Assess the Safety, Tolerability and Pharmacokinetics of Repeated Dosing Regimens of AL-794 in Healthy Volunteers

Condition: Healthy
Interventions: Drug: AL-794; Drug: Placebo
Sponsor: Alios Biopharma Inc.
Terminated
A Study to Assess Safety, Tolerability and Pharmacokinetics of GLPG2737 in Healthy Subjects

Condition: Healthy
Interventions: Drug: GLPG2737 single dose; Drug: Placebo single dose; Drug: GLPG2737 multiple dose
Sponsor: Galapagos NV
Completed
Efficacy of Different Doses of Amino Acids in 5AA+CrPic Water on Glucose Homeostasis in a Healthy Population.

Condition: Healthy
Interventions: Dietary Supplement: 5AA+CrPic Water; Other: Placebo drink
Sponsors: DoubleGood AB; Lund University; Aventure AB
Completed
Motivational Interviewing for Getting Healthy TodaY Study

Conditions: Pregnancy Related; Diet Modification
Interventions: Behavioral: CAMI-TPP; Behavioral: CAMI-Fitness
Sponsors: Columbia University; The Office of Adolescent Health, HHS; Centers for Disease Control and Prevention
Not yet recruiting
A Study to Investigate Safety and Tolerability, Pharmacokinetics and Pharmacodynamics of JNJ-55375515 in Healthy Male Participants

Condition: Healthy
Interventions: Drug: JNJ-55375515 Dose Level 1; Drug: JNJ-55375515 Dose Level 2; Drug: JNJ-55375515 Dose Level 3; Drug: JNJ-55375515 Dose Level 4; Drug: JNJ-55375515 Dose Level 5; Drug: JNJ-55375515 Dose Level 6; Drug: Placebo; Drug: JNJ-55375515
Sponsor: Janssen Research & Development, LLC
Completed
A Study of Lasmiditan in Healthy Elderly Participants

Condition: Healthy
Interventions: Drug: Lasmiditan; Drug: Placebo
Sponsor: Eli Lilly and Company
Completed
Safety and Pharmacokinetic Study of Inhaled Esketamine in Healthy Volunteers

Condition: Healthy Volunteers
Interventions: Drug: Esketamine DPI; Drug: Placebo DPI
Sponsors: Celon Pharma SA; The National Centre for Research and Development, Poland
Completed
A First-In-Human Study of Orally Administered JNJ-64417184 to Evaluate the Safety, Tolerability, and Pharmacokinetics of Single and Multiple Ascending Doses, and the Antiviral Activity of Multiple Doses in a Respiratory Syncytial Virus (RSV) Challenge Study in Healthy Participants

Condition: Healthy
Interventions: Drug: JNJ-64417184; Drug: Placebo
Sponsor: Alios Biopharma Inc.
Recruiting
This Study in Healthy Men Tests How Itraconazole Influences the Amount of BI 1015550 in the Blood

Condition: Healthy
Interventions: Drug: BI 1015550; Drug: itraconazole
Sponsor: Boehringer Ingelheim
Completed
Study of Lanadelumab in Healthy Japanese and Matched Caucasian Adult Subjects

Condition: Healthy Volunteers
Intervention: Drug: Lanadelumab
Sponsor: Shire
Completed
Effect of Acotiamide on Gastric Motility and Satiation in Healthy Volunteers

Condition: Healthy
Interventions: Drug: Acotiamide; Drug: Placebo Oral Tablet
Sponsor: Universitaire Ziekenhuizen Leuven
Completed
Study to Assess the Safety, Tolerability, and Pharmacokinetics of E2082 in Healthy Male Subjects

Condition: Healthy Participants
Interventions: Drug: E2082; Drug: Placebo
Sponsor: Eisai Co., Ltd.
Recruiting
Evaluation of IM Letrozole ISM® Pharmacokinetics, Safety, and Tolerability in Healthy Post-menopausal Women (LISA-1)

Condition: Healthy
Intervention: Drug: Letrozole ISM
Sponsor: Rovi Pharmaceuticals Laboratories
Recruiting
Effects of Exercises Combined With Blood Flow Restriction in Healthy Individuals

Condition: Healthy Individuals
Intervention: Other: Exercise group
Sponsor: Dokuz Eylul University
Not yet recruiting
A Study to Assess the Nicotine Pharmacokinetics, Tolerability and Safety With a New Oral Nicotine Replacement Product in Healthy Japanese Smokers

Condition: Healthy
Interventions: Drug: Oromucosal Nicotine Spray (ONS); Drug: Nicotine Gum; Other: Cigarette
Sponsor: Janssen Pharmaceutical K.K.
Completed
Bioequivalence Study Between a 4-mg Dose of Fine Granules of Perampanel and a 4-mg Tablet of Perampanel in Healthy Japanese Subjects

Condition: Healthy Participants
Intervention: Drug: Perampanel
Sponsor: Eisai Co., Ltd.
Active, not recruiting
Study to Evaluate the Relative Bioavailability and Safety of the AG-348 Tablet and Capsule Formulations in Healthy Adults

Condition: Healthy Volunteers
Interventions: Drug: AG-348 Sequence A; Drug: AG-348 Sequence B
Sponsor: Agios Pharmaceuticals, Inc.
Completed
Assessing the Drug Exposure Risk of Infants Breastfed by Women With Inflammatory Bowel Disease

Conditions: Crohn's Disease; Ulcerative Colitis; Healthy Controls
Intervention:
Sponsors: The Hospital for Sick Children; Mount Sinai Hospital, New York; Crohn's and Colitis Foundation
Recruiting
A Study Comparing The Effects Of Epoetin Hospira Single-Dose Vial (SDV) And Multi-Dose Vial (MDV) When Administered Subcutaneously To Normal Healthy Subjects

Condition: Healthy
Interventions: Drug: Epoetin Hospira SDV; Drug: Epoetin Hospira MDV
Sponsor: Pfizer
Completed
Developing and Validating Food-based Dietary Guidelines and a Healthy Eating Index

Condition: Healthy
Intervention: Behavioral: Food-based dietary guidelines for healthier diet
Sponsors: Ethiopian Public Health Institute; Wageningen University; Food and Agriculture Organization (FAO); International Food Policy Research Institute
Not yet recruiting
Efficacy of Fish Oil or Olive Oil Supplementation on the Health Effects of Ozone Exposure in Healthy Young Subjects

Conditions: Healthy; Dietary Supplement
Interventions: Drug: Ozone; Dietary Supplement: Fish Oil; Dietary Supplement: Olive Oil
Sponsors: University of North Carolina, Chapel Hill; Environmental Protection Agency (EPA)
Recruiting
Evaluation of Gadolinium Deposits in Healthy Women Participating in a High Risk Screening Program for Early Breast Cancer Detection

Condition: Gd-based Contrast Media Exposure During Breast MRI Scans
Intervention: Diagnostic Test: Brain MRI scan
Sponsor: Medical University of Vienna
Recruiting
The Healthy School Start Plus Intervention Study

Conditions: Prevention; Overweight and Obesity; Dietary Habits; Physical Activity; Parent-Child Relations
Intervention: Behavioral: A Healthy School Start Plus intervention
Sponsors: Karolinska Institutet; The Kamprad Family Foundation for Entrepreneurship, Research & Charity; Swedish research council for health, working life and welfare
Active, not recruiting
A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics in Healthy Adult Male Participants

Condition: Healthy Participants
Interventions: Drug: E6130; Drug: Placebo
Sponsor: EA Pharma Co., Ltd.
Withdrawn
A Trial to Demonstrate the Equivalent Pharmacokinetic Properties of HD204 and Bevacizumab (Avastin®) in Healthy Male Subjects

Condition: Healthy Volunteers
Interventions: Drug: HD204; Drug: Avastin
Sponsor: Prestige Biopharma Pte Ltd
Recruiting
Anti-Shiga Toxin Hyperimmune Equine Immunoglobulin F(ab')2 Fragment (INM004) in Healthy Volunteers

Condition: Healthy Volunteers
Interventions: Biological: Drug: INM004 Dose 1; Biological: Drug: INM004 Dose 2; Biological: Drug: INM004- Repeated dose; Other: Placebo
Sponsors: Inmunova S.A.; Hospital Italiano de Buenos Aires
Recruiting
A Study To Determine The Effect Of Single-dose PF-04965842 On QTc Interval In Healthy Volunteers Compared With Placebo and Moxifloxacin

Condition: Healthy Volunteers
Interventions: Drug: PF-04965842; Drug: Moxifloxacin; Drug: Placebo
Sponsor: Pfizer
Completed
Study of a Single Dose of PRS-060 Administered by Oral Inhalation or IV Infusion in Healthy Subjects

Condition: Healthy Subjects
Interventions: Drug: PRS-060; Drug: Placebo
Sponsor: Pieris Australia Pty Ltd
Recruiting
A Pharmacokinetic (PK) Study of ACH-0144471 Modified Release Prototype Formulations in Healthy Subjects

Condition: Healthy Volunteers
Interventions: Drug: ACH-0144471 Modified Release Prototype 1; Drug: ACH-0144471 Modified Release Prototype 2; Drug: ACH-0144471 Modified Release Prototype 3; Drug: ACH-0144471 Modified Release Prototype 4; Drug: ACH-0144471 Modified Release Prototype 5
Sponsors: Achillion Pharmaceuticals; Quotient Sciences
Completed
Exploration of the Modulation of Skin Microbiota and Odor Components by Introduction of Stress in Healthy Male Subjects

Condition: Emotional Stress
Intervention: Other: adapted STMST
Sponsors: NIZO Food Research; Procter and Gamble
Completed
In Vivo Assessment of Glutamine Utilization by Bone Marrow Plasma Cells

Condition: Healthy
Interventions: Other: 5-13C-Glutamine; Other: Bone marrow aspiration
Sponsor: Mayo Clinic
Active, not recruiting
This Study Tests BI 1467335 in Healthy Male Volunteers. The Study Tests How Different Doses of BI 1467335 Are Taken up and Handled by the Body.

Condition: Healthy
Interventions: Drug: [14C]BI 1467335; Drug: BI 1467335
Sponsor: Boehringer Ingelheim
Completed
Phase 1 Study for Safety and Tolerability of IL-1-Ra Topically Administered to Eyes of Healthy Adult Subjects

Condition: Blepharokeratoconjunctivitis
Intervention: Drug: IL-1Ra
Sponsors: Beijing Tongren Hospital; Chengdu Rhodiola Bio-Pharmaceutical Co Ltd
Recruiting
Healthy Body Healthy Souls: A Weight Loss Intervention Using Diabetes Prevention Program Lifestyle Intervention (DPP-LI) With Church Level Systems Change in the Marshallese Population

Condition: Weight Loss
Intervention: Behavioral: Diabetes Prevention Program Lifestyle Intervention (DPP-LI) with Healthy Bodies Healthy Souls (HBHS)
Sponsor: University of Arkansas
Enrolling by invitation
Study to Assess the Bioavailability, Pharmacokinetics, Safety, and Tolerability of AVP-923 in Healthy Adult Participants

Condition: Healthy Adult Male and Female Volunteers
Intervention: Drug: AVP-923
Sponsor: Avanir Pharmaceuticals
Completed
Effect of Cimetidine on the Pharmacokinetics of Lucerastat in Healthy Subjects

Condition: Healthy Subjects
Interventions: Drug: Lucerastat; Drug: Cimetidine
Sponsor: Idorsia Pharmaceuticals Ltd.
Completed
A Study of the Safety, Tolerability, Pharmacokinetics and Pharmacodynamic Effects of Single and Multiple Ascending Doses of GDC-0334 and the Effect of Food on the Pharmacokinetics of GDC-0334 in Healthy Adult Participants

Condition: Healthy Volunteers
Interventions: Drug: GDC-0334; Drug: Placebo
Sponsor: Genentech, Inc.
Recruiting
A Study to Investigate the Pharmacokinetics, Safety, and Tolerability of Emicizumab in Healthy Chinese Volunteers

Conditions: Healthy Volunteers; Hemophilia A
Intervention: Drug: Emicizumab
Sponsor: Hoffmann-La Roche
Completed
A Study in Healthy Participants Evaluating the Absorption of a BMS-986205 Tablet Into the Bloodstream Compared to a Reference Tablet

Condition: Healthy Volunteers
Interventions: Drug: BMS-986205 reference tablet; Drug: BMS-986205 tablet with free base
Sponsor: Bristol-Myers Squibb
Completed
Study to Evaluate Bioavailability of a Single 12 mg Dose of Perampanel for Three Intravenous Infusion Durations Relative to a Single 12 mg Perampanel Oral Tablet in Healthy Subjects

Condition: Healthy Participants
Intervention: Drug: Perampanel
Sponsor: Eisai Inc.
Completed
Study of the Choroidal and Retinal Thickness in Relation to Axial Length.

Condition: Healthy
Interventions: Device: AL measurement; Device: OCT
Sponsor: Semmelweis University
Active, not recruiting
A Study to Evaluate Safety, Tolerability, and PD of Tegoprazan on Healthy Male Volunteers

Conditions: Pharmacodynamics; Healthy Male Volunteers
Interventions: Drug: Tegoprazan; Drug: Revaprazan
Sponsor: CJ HealthCare Corporation
Completed
Assessing the Safety and Tolerability of CSL730 in Healthy Caucasian and Japanese Adults

Condition: Healthy
Interventions: Biological: CSL730; Other: Placebo
Sponsor: CSL Behring
Active, not recruiting
A Study to Investigate Safety and Tolerability, Pharmacokinetics and Pharmacodynamics of JNJ-63733657 in Healthy Subjects and Subjects With Alzheimer's Disease

Condition: Alzheimer Disease
Interventions: Drug: JNJ-63733657; Drug: Placebo
Sponsor: Janssen Research & Development, LLC
Recruiting
A Study of LY3298176 in Healthy Participants

Condition: Healthy
Interventions: Drug: LY3298176; Drug: Placebo
Sponsor: Eli Lilly and Company
Active, not recruiting
A Study of MG1111 in Healthy Children

Condition: Healthy Children
Intervention: Drug: Varicella Vaccine
Sponsor: Green Cross Corporation
Recruiting
A Study Using Healthy Volunteers Comparing Belatacept Which Has Been Manufactured By 2 Different Processes

Condition: Healthy Volunteers
Intervention: Drug: belatacept
Sponsor: Bristol-Myers Squibb
Active, not recruiting
Neutrophil Extracellular Traps in Systemic Sclerosis

Conditions: Systemic Lupus Erythematosus; Systemic Sclerosis
Intervention: Other: Blood sample
Sponsor: CHU de Reims
Recruiting
Oral Bioavailability,and Food Effect Study and Single Ascending Dose PK Study in Healthy Male Volunteers

Condition: Healthy
Interventions: Drug: Indoximod base formulation; Drug: Indoximod HCL (salt) formulation; Other: Placebo
Sponsor: NewLink Genetics Corporation
Recruiting
A Study to Evaluate if ID-085 is Safe, Its Fate in the Body as Well as Its Potential Effects on the Body in Healthy Subjects

Condition: Healthy Subjects
Interventions: Drug: ID-085; Drug: Placebo oral capsule
Sponsor: Idorsia Pharmaceuticals Ltd.
Recruiting
A Study To Evaluate Different Formulations Of PF-06865571 In Healthy Subjects

Condition: Healthy
Interventions: Drug: PF-06865571 Immediate release suspension; Drug: PF-06865571 Slow release MR tablets; Drug: PF-06865571 Fast release MR tablets; Drug: PF-06865571 Immediate release tablets
Sponsor: Pfizer
Completed
coMparison Between invAsive and Non-invasive assessmenT on Blood Pressure and Cardiac Function in HealthY Participants

Condition: Healthy Volunteer
Interventions: Diagnostic Test: Invasive left ventricular diastolic function assessment; Diagnostic Test: Invasive aortic blood pressure measurement; Diagnostic Test: Non-Invasive left ventricular diastolic function assessment; Diagnostic Test: Non-Invasive aortic blood pressure measurement
Sponsor: Shanghai 10th People's Hospital
Not yet recruiting
Assessment of Change in CYP3A Activity by Route of Administration Using Metabolic Markers in Healthy Male Volunteers

Condition: Healthy Volunteers
Interventions: Drug: Midazolam; Drug: Clarithromycin; Dietary Supplement: Grapefruit juice
Sponsor: Seoul National University Hospital
Recruiting
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of DWP16001 After Oral Administration in Healthy Male Volunteers

Condition: Healthy
Interventions: Drug: DWP16001; Drug: Placebo; Drug: Dapagliflozin
Sponsor: Daewoong Pharmaceutical Co. LTD.
Recruiting
A Study to Assess the Absorption of a Single Dose of BMS-986205 in Healthy Volunteers When Administered as a Crushed Tablet Orally or Crushed Tablet Suspension Via Nasogastric Tube, as Compared to a Tablet

Condition: Healthy Volunteers
Intervention: Drug: BMS-986205
Sponsor: Bristol-Myers Squibb
Completed
Study of Pharmacodynamic Equivalence of Enoxaparin Rovi to Clexane®, in Healthy Volunteers

Condition: Healthy
Interventions: Drug: Enoxaparin; Drug: Clexane
Sponsors: Rovi Pharmaceuticals Laboratories; PRA Health Sciences
Completed
Pharmacokinetic Interaction Between Midazolam and ID-082 in Healthy Subjects

Condition: Healthy
Interventions: Drug: Midazolam; Drug: ID-082
Sponsor: Idorsia Pharmaceuticals Ltd.
Completed
ASP8302 Single and Multiple Ascending Oral Dose Study in Non-elderly Healthy Japanese Subjects

Condition: Healthy Subjects
Interventions: Drug: ASP8302; Drug: Placebo
Sponsor: Astellas Pharma Inc
Completed
A Study of Dulaglutide in Healthy Participants

Condition: Healthy
Interventions: Drug: Dulaglutide (Reference); Drug: Dulaglutide (Test)
Sponsor: Eli Lilly and Company
Completed
A 4-Part Study In Healthy Volunteers To Evaluate Safety And Tolerability Of The Test Medicine MEDI7219 and to See How it is Taken up by the Body When Given as Single and Multiple Doses

Condition: Healthy Volunteers
Interventions: Drug: MEDI7219; Drug: Placebo; Drug: Formulation without Active Drug
Sponsor: MedImmune LLC
Recruiting
A Study Evaluating the Effect of a Single-dose Oral Administration of Nemonoxacin Capsule on QTc Intervals and Heart Rhythms of Healthy Subjects and the Influence of Food Intake on QTc Intervals and Pharmacokinetic Characteristics

Condition: Healthy Volunteers
Interventions: Drug: Nemonoxacin 500Mg Capsule; Drug: Moxifloxacin 400Mg Tablet; Drug: Nemonoxacin 750Mg Capsule; Drug: Placebo oral capsule
Sponsor: TaiGen Biotechnology Co., Ltd.
Completed
Clinical Study to Investigate the Effect of Macitentan on the Concentrations of Rosuvastatin in the Blood of Healthy Male Subjects

Condition: Healthy Subjects
Interventions: Drug: Rosuvastatin; Drug: Macitentan
Sponsor: Actelion
Completed
A Phase 1 Pharmacokinetic, Safety, Tolerability and Immunogenicity Study of HLX3 and Adalimumab in Chinese Healthy Male Subjects

Condition: Pharmacokinetics, Safety, Toleratiblity and Immunogenicity Comparison Between a Biosimilar and Humira in Healthy Volunteers
Intervention: Drug: HLX03 Adalimumab Injection
Sponsor: Shanghai Henlius Biotech
Active, not recruiting
A Study to Evaluate the Safety, Reactogenicity and Immunogenicity of Ad26.ZIKV.001 in Healthy Adult Volunteers

Condition: Healthy
Interventions: Biological: Ad26.ZIKV.001 5*10^10 vp; Biological: Ad26.ZIKV.001 1*10^11 vp; Biological: Placebo
Sponsor: Janssen Vaccines & Prevention B.V.
Recruiting
A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Repeat Doses of PF-06372865 in Healthy Subjects

Condition: Healthy Volunteers
Interventions: Drug: Placebo; Drug: PF-06372865
Sponsor: Pfizer
Completed
This Study Tests the Safety, Tolerability and How Different Doses of BI 1265162 Are Taken up in the Body of Healthy Men

Condition: Healthy
Interventions: Drug: BI 1265162; Drug: Placebo
Sponsor: Boehringer Ingelheim
Completed
A Pilot Study of Small Fiber Neuropathy Prevalence in Fibromyalgia Patients Compared to Healthy Subjects Using Sudoscan®

Condition: Fibromyalgia
Intervention: Device: Sudoscan®
Sponsor: University Hospital, Clermont-Ferrand
Recruiting
SPM Regulation by Fish Oil Supplements in Healthy Volunteers

Condition: Healthy Volunteers
Intervention: Dietary Supplement: SPM Active
Sponsors: Queen Mary University of London; Metagenics, Inc.
Active, not recruiting
A Study to Investigate the Safety, Tolerability and Pharmacokinetics of JNJ-64991524 in Healthy Participants

Condition: Healthy
Interventions: Drug: JNJ-64991524 Dose Level 1; Drug: JNJ-64991524 Dose Level 2; Drug: JNJ-64991524 Dose Level 3; Drug: JNJ-64991524 Dose Level 4; Drug: JNJ-64991524 Dose Level 5; Drug: JNJ-64991524 Dose Level 6; Drug: Placebo; Drug: JNJ-64991524 Dose Level 7; Drug: JNJ-64991524 Dose Level 8; Drug: JNJ-64991524 Dose Level 9
Sponsor: Janssen Research & Development, LLC
Recruiting
A Study of LY3375880 in Healthy Participants

Condition: Healthy
Interventions: Drug: LY3375880 IV; Drug: LY3375880 SC; Drug: Placebo IV; Drug: Placebo SC
Sponsor: Eli Lilly and Company
Active, not recruiting
Evolution of Total Energy Expenditure and Its Various Components in Active Rheumatoid Arthritis (RA)Treated With Anti-TNF Agents and Comparison With Healthy Subjects

Condition: Active Rheumatoid Arthritis
Intervention: Behavioral: Energy metabolism of patients suffering from RA
Sponsors: University Hospital, Clermont-Ferrand; Centre de Recherche en Nutrition Humaine d'Auvergne
Not yet recruiting
An Investigational Study to Assess the Effect of BMS-986177 on Aspirin in Healthy Participants

Condition: Healthy Volunteers
Interventions: Drug: Aspirin; Drug: BMS-986177; Drug: Placebo
Sponsor: Bristol-Myers Squibb
Completed
A Study to Evaluate Pharmacokinetics of Sonazoid™ Following Intravenous Bolus Injection in Healthy Volunteers

Condition: Healthy
Intervention: Drug: Sonazoid™
Sponsor: GE Healthcare
Completed
Lexical Priming by Music in Alzheimer's Disease and Healthy Aging

Condition: Alzheimer Disease
Interventions: Other: Exposure to familiar songs; Other: Music Experience Questionnaire; Other: Implicit tasks memory; Other: Questionnaires
Sponsor: Centre Hospitalier Universitaire de Saint Etienne
Recruiting
A Study in Healthy Male Subjects to Investigate Whether Administration of ACT-541468 Can Affect the Fate in the Body (Amount and Time of Presence in the Blood) of Rosuvastatin

Condition: Healthy Subjects
Interventions: Drug: Rosuvastatin; Drug: ACT-541468
Sponsor: Idorsia Pharmaceuticals Ltd.
Completed
Electrical Stimulation With Different Currents: the Effects on Force, Tolerance and Fatigue in Healthy Subjects

Condition: Healthy
Interventions: Device: Neo-Russian; Device: Aussie; Device: RBS; Device: Fatigue Test
Sponsor: Instituto Universitario de Ciencias de la Salud Fundación H.A. Barceló
Completed
South Asian Healthy Lifestyle Initiative (SAHELI)

Condition: Cardiovascular Risk Factor
Intervention: Behavioral: South Asian Healthy Lifestyle Initiative (SAHELI)
Sponsors: Northwestern University; Metropolitan Asian Family Services; Skokie Health Department; NorthShore University HealthSystem; Case Western Reserve University; Shirley Ryan AbilityLab
Recruiting
Molar Potency Study of HM12470 in Healthy Subjects

Condition: Healthy Subjects
Intervention: Biological: HM12470
Sponsor: Hanmi Pharmaceutical Company Limited
Completed
Molar Potency Study of HM12460A in Healthy Subjects

Condition: Healthy Volunteers
Intervention: Biological: HM12460A
Sponsor: Hanmi Pharmaceutical Company Limited
Completed
Phase 1 TAK-925 Study in Healthy Adult and Elderly Volunteers and Patients With Narcolepsy

Condition: Healthy Participants and Patients With Narcolepsy
Interventions: Drug: TAK-925; Drug: Placebo
Sponsor: Takeda
Completed
A Study to Compare 2 Formulations of LY900014 in Healthy Participants

Condition: Healthy
Interventions: Drug: LY900014-U200; Drug: LY900014-U100
Sponsor: Eli Lilly and Company
Completed
Growth and Safety Study of an Infant Formula for Healthy Term Infants

Condition: Infant Development
Interventions: Other: Formula B; Other: Formula A
Sponsors: Building Block Nutritionals, LLC; Paidion Research, Inc.
Recruiting
Family-centered Obesity Prevention: Communities for Healthy Living (CHL)

Conditions: Pediatric Obesity; Obesity
Interventions: Behavioral: Parents Connect for Healthy Living (PConnect); Behavioral: Enhanced Nutrition Support; Behavioral: Media Resources
Sponsors: Harvard School of Public Health; Action for Boston Community Development; Community Action Agency of Somerville
Enrolling by invitation
An Exploratory Study to Evaluate the Prophylactic Efficacy of a Single Immunization of Ad26.RSV.preF Against Respiratory Syncytial Virus Infection in a Virus Challenge Model in Healthy 18 to 50 Year-old Adults

Condition: Healthy
Interventions: Biological: Ad26.RSV.preF; Drug: Placebo
Sponsor: Janssen Vaccines & Prevention B.V.
Active, not recruiting
A Study of Experimental Medication BMS-986251, Taken by Mouth, in Healthy Patients and Patients With Average to Very Serious Psoriasis

Conditions: Rheumatoid Arthritis; Psoriasis; Ankylosing Spondylitis; Inflammatory Bowel Diseases; Nonalcoholic Steatohepatitis
Interventions: Drug: BMS-986251; Other: Placebo
Sponsor: Bristol-Myers Squibb
Terminated
A Study of Multiple Doses of LY3305677 in Healthy Participants

Condition: Healthy
Interventions: Drug: LY3305677; Drug: Placebo
Sponsor: Eli Lilly and Company
Completed
This Study in Healthy Men Tests How Different Doses of BI 705564 Are Taken up in the Body and How Well They Are Tolerated. The Study Also Tests How BI 705564 Affects the Way the Body Breaks Down Midazolam

Condition: Healthy
Interventions: Drug: BI 705564; Drug: Placebo
Sponsor: Boehringer Ingelheim
Recruiting
Visual Field Defect Estimation Using Sequentially Optimized Reconstruction Strategy on Healthy and Glaucoma Subjects

Condition: Glaucoma, Open-Angle
Intervention: Diagnostic Test: Visual field testing
Sponsors: University Hospital Inselspital, Berne; University of Bern
Recruiting
Providing Healthy Food Access and Physical Activity Opportunities at Boy Scouts of America Summer Camp

Condition: Childhood Obesity
Intervention: Behavioral: Focus Group with Participants
Sponsors: Milton S. Hershey Medical Center; Boy Scouts of America
Completed
Study of ORIC-101 in Healthy Adult Subjects

Condition: Healthy Volunteers
Intervention: Drug: ORIC-101
Sponsor: Oric Pharmaceuticals
Completed
A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of JNJ-54767414 (Daratumumab) in Healthy Participants

Condition: Healthy
Interventions: Drug: Daratumumab; Drug: Placebo
Sponsor: Janssen Research & Development, LLC
Recruiting
A Study of AK0529 to Evaluate Pharmacokinetics and Safety in Chinese Healthy Volunteers

Condition: Healthy
Interventions: Drug: AK0529; Other: Placebo
Sponsor: Ark Biosciences Inc.
Completed
Healthy Summer Learners

Conditions: Overweight and Obesity; Academic Acheivement
Interventions: Behavioral: Healthy Summer Learners; Behavioral: 21st Century Summer Learning Center
Sponsor: University of South Carolina
Recruiting
Pharmacodynamic and Safety of MEDITOXIN® in Healthy Male Volunteers

Condition: Healthy
Interventions: Drug: Meditoxin; Drug: Botox
Sponsor: Medy-Tox
Recruiting
A Study to Evaluate the Pharmacokinetics of Dexlansoprazole 30 Milligram (mg) and 60 mg Delayed-release Capsules in Healthy Chinese Participants

Condition: Healthy Volunteers
Intervention: Drug: Dexlansoprazole
Sponsor: Takeda
Completed
First-in-human Study in Healthy Subjects

Condition: Healthy
Interventions: Drug: CORT118335, 25 mg; Drug: Prednisone Oral Tablet; Drug: Glucose; Drug: Placebo oral suspension; Drug: CORT118335, 75mg; Drug: CORT118335, 225mg; Drug: CORT118335, 675mg; Drug: CORT118335, 600mg; Drug: CORT118335, 630mg; Drug: CORT118335, 375mg; Drug: CORT118335, 100mg; Drug: CORT118335, 300mg; Drug: CORT118335, 900mg; Drug: CORT118335, 150mg; Drug: CORT118335, 1500mg; Drug: Placebo oral capsule; Drug: CORT118335, dose to be determined
Sponsor: Corcept Therapeutics
Recruiting
Bioavailability Study of K0706 in Healthy Subjects

Condition: Healthy
Intervention: Drug: K0706
Sponsor: Sun Pharma Advanced Research Company Limited
Completed
This Study in Healthy Men Tests How Different Doses of BI 894416 Are Taken up in the Body and How Well BI 894416 is Tolerated

Condition: Healthy
Interventions: Drug: BI 894416; Drug: Placebo; Drug: BI 894416 (treatment X and Z); Drug: BI 894416 (treatment Y)
Sponsor: Boehringer Ingelheim
Completed
Investigating Memory Retrieval Improvement in Healthy Subjects

Condition: Healthy Adults
Interventions: Device: active anodal tDCS; Device: sham tDCS; Device: active cathodal tDCS
Sponsor: The University of Texas at Dallas
Active, not recruiting
The Tolerance, Pharmacokinetics of Jaktinib in Healthy Volunteers

Condition: Healthy Volunteers
Interventions: Drug: Jaktinib Dihydrochloride Monohydrate; Drug: placebo
Sponsor: Suzhou Zelgen Biopharmaceuticals Co.,Ltd
Recruiting
An Investigational Study to Assess the Effect of a Light Meal and a High-Fat Meal on the Absorption of BMS-986205 in Healthy Participants

Condition: Healthy Volunteers
Intervention: Drug: BMS-986205
Sponsor: Bristol-Myers Squibb
Completed
Pharmacokinetics of Lidocaine in Healthy Adults

Condition: Healthy
Interventions: Drug: Lidocaine patch 5%; Drug: Lidocaine Hydrochloride; Drug: Lidoderm 5 % Topical Patch
Sponsors: Nicole K Brogden; Long Island University
Recruiting
A Study of Lasmiditan When Given With Sumatriptan in Healthy Participants

Condition: Healthy
Interventions: Drug: Lasmiditan; Drug: Sumatriptan; Drug: Placebo for Lasmiditan; Drug: Placebo for Sumatriptan
Sponsor: Eli Lilly and Company
Completed
Investigating Accelerated Learning and Memory in Healthy Subjects Using a Face Name Memory Task

Condition: Healthy Adults
Interventions: Device: tDCS; Device: sham tDCS
Sponsor: The University of Texas at Dallas
Active, not recruiting
First In Human, Single Escalating Oral Dose Study Of PF-06882961 In Healthy Adult Subjects

Condition: Healthy Subjects
Interventions: Drug: PF-06882961; Other: Placebo
Sponsor: Pfizer
Completed
A Study of Lasmiditan in Healthy Participants When Co-administered With Topiramate

Condition: Healthy
Interventions: Drug: Lasmiditan; Drug: Placebo; Drug: Topiramate
Sponsor: Eli Lilly and Company
Completed
Recruitment and Characterization of Healthy Research Volunteers for NIMH Intramural Studies

Condition: Healthy Volunteer
Intervention:
Sponsor: National Institute of Mental Health (NIMH)
Recruiting
A Phase 1, Pharmacokinetics of the MMP-12 Inhibitor FP-025 After Multiple Oral Ascending Doses in Healthy Subjects

Condition: Healthy
Intervention: Drug: FP-025 (MMP-12 inhibitor)
Sponsor: Foresee Pharmaceuticals Co., Ltd.
Completed
Study to Determine and Compare Plasma and Intrapulmonary Concentrations of ETX2514 and Sulbactam in Healthy Subjects

Condition: Healthy
Intervention: Drug: ETX2514 and sulbactam
Sponsors: Entasis Therapeutics; Clinartis
Completed
Bioequivalence Study of Ritonavir Versus NORVIR in Healthy Chinese Subjects

Condition: Healthy Volunteer
Interventions: Drug: Ritonavir for cycle1 and NORVIR for cycle 2; Drug: NORVIR for cycle 1 and Ritonavir for cycle 2
Sponsors: First Affiliated Hospital of Zhejiang University; Ascletis Pharmaceuticals Co., Ltd.
Completed
Phase 1 Study to Investigate Effect of Rifampin and Itraconazole on the Pharmacokinetics of BGB-3111 in Healthy Subjects

Condition: Healthy Volunteers: Asian, Non-Asian
Interventions: Drug: BGB-3111 (Arm A); Drug: Rifampin; Drug: BGB-3111 (Arm B); Drug: Itraconazole
Sponsor: BeiGene
Completed
Testing of a Valsalva Assist Device (VAD) in Healthy Volunteers Performing a Valsalva Manoeuvre

Conditions: SVT; Vagal Bradycardia
Interventions: Device: Supine VM VAD; Device: Supine VAD manometer; Other: Modified VM VAD; Other: Modified VM Manonmeter
Sponsors: University of Exeter; Royal Devon and Exeter NHS Foundation Trust
Completed
Dolcanatide in Preventing Colorectal Cancer in Healthy Volunteers

Condition: Healthy Subject
Interventions: Drug: Dolcanatide; Other: Laboratory Biomarker Analysis; Other: Placebo; Other: Questionnaire Administration
Sponsor: National Cancer Institute (NCI)
Recruiting
Relative Bioavailability of BI 1015550 Following Oral Administration Under Fed and Fasted Conditions in Healthy Male Subjects

Condition: Healthy
Intervention: Drug: BI 1015550
Sponsor: Boehringer Ingelheim
Completed
Placebo-Controlled Single Dose Study to Evaluate Safety and Pharmacokinetics of SXC-2023 in Healthy Volunteers

Condition: Healthy
Intervention: Drug: SXC-2023 or Placebo
Sponsors: Promentis Pharmaceuticals, Inc.; Celerion
Completed
Development of Applications of PillCam™ Endoscopy and Patency Systems and Clinical Evaluation of Their Performance in Healthy Volunteers ("HEIGHT" Study)

Condition: Healthy
Interventions: Device: PillCam™ Endoscopy System; Drug: Bowel prep combination
Sponsor: Medtronic - MITG
Recruiting
28-Day Repeat-Dose, Dose Escalation Study of 11-β Methyl Nortestosterone Dodecylcarbonate (11β-MNTDC) in Healthy Men

Conditions: Healthy Men; Male Contraception
Interventions: Drug: Placebo; Drug: 11β-methyl-nortestosterone-dodecylcarbonate
Sponsors: Health Decisions; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD); Los Angeles Biomedical Research Institute; University of Washington
Recruiting
Looking Glass: Bimanual Balanced Reaching With Visual Biofeedback

Conditions: Stroke; Stroke, Acute; Healthy
Interventions: Other: Veridical Visual Feedback; Other: Augmented Visual Feedback; Other: Healthy Comparative Reaching Task
Sponsor: Shirley Ryan AbilityLab
Recruiting
The HealthyMoms Trial to Promote Healthy Gestational Weight Gain

Conditions: Gestational Mothers; Weight Gain
Intervention: Behavioral: Mobile phone based intervention
Sponsor: Karolinska Institutet
Recruiting
A Study to Assess the Effect of Ticlopidine on the Pharmacokinetics, Safety, and Tolerability of Intranasally Administered Esketamine in Healthy Participants

Condition: Healthy
Interventions: Drug: Esketamine; Drug: Ticlopidine
Sponsor: Janssen Research & Development, LLC
Completed
Biomarkers in Saliva and Stool

Condition: Healthy
Intervention: Other: No internvetion
Sponsor: Danone Asia Pacific Holdings Pte, Ltd.
Terminated
Healthy Kids Pilot

Condition: Childhood Obesity
Intervention: Behavioral: m-Health Intervention
Sponsor: Pennington Biomedical Research Center
Recruiting
Radiolabeled Study of CC-220 in Healthy Male Subjects

Condition: Healthy Volunteer
Interventions: Drug: CC-220; Radiation: [14C]
Sponsor: Celgene
Completed
Healthy Kids I-PAL

Condition: Childhood Obesity
Intervention: Behavioral: m-health approach
Sponsors: Pennington Biomedical Research Center; Southeastern Louisiana University
Completed
A Pharmacokinetic Study Comparing MB02 And US And EU Avastin® In Healthy Male Volunteers

Condition: Healthy Volunteers
Interventions: Drug: MB02; Drug: US licenced Avastin®; Drug: EU approved Avastin®
Sponsor: mAbxience S.A
Recruiting
A Study to Investigate the Effect of Formulation, Food, and Rabeprazole on the Pharmacokinetics (PK) of GDC-0853 in Healthy Participants

Condition: Healthy Volunteers
Interventions: Drug: GDC-0853; Drug: Rabeprazole
Sponsor: Genentech, Inc.
Completed
To Compare the Gastrointestinal Safety of a 14-Day Oral Dosing Regimen of ATB-346 to Sodium Naproxen in Healthy Subjects

Condition: Gastric Ulcer
Interventions: Drug: ATB-346 OR Placebo; Drug: Naproxen sodium
Sponsor: Antibe Therapeutics Inc.
Completed
A Study to Assess the Pharmacodynamic Effects of SAGE-217 in Healthy Adults Using an Insomnia Model

Condition: Healthy
Interventions: Drug: SAGE-217 high dose; Drug: Placebo; Drug: SAGE-217 low dose
Sponsor: Sage Therapeutics
Completed
A Safety and Pharmacodynamic Study of Healthy Chinese Subjects Administered Sodium Zirconium Cyclosilicate (ZS)

Condition: Hyperkalemia
Intervention: Drug: Sodium Zirconium Cyclosilicate (ZS)
Sponsor: AstraZeneca
Completed
A Single Dose Study Evaluating PK of TXL Oral Formulations in Healthy Subjects

Condition: Healthy Volunteers
Intervention: Drug: Tenofovir exalidex (TXL)
Sponsor: ContraVir Pharmaceuticals, Inc.
Completed
Trial to Evaluate the PK Profile of Glepaglutide (ZP1848) After a Single IV and After Multiple SC Injections in Healthy Subjects

Condition: Healthy Subjects
Intervention: Drug: Glepaglutide
Sponsor: Zealand Pharma
Completed
This Study Tests How Healthy Men Tolerate Different Doses of BI 730357 and How the Metabolism of Midazolam is Affected by BI 730357

Conditions: Healthy; Psoriasis
Interventions: Drug: BI 730357; Drug: Placebo; Drug: Midazolam
Sponsor: Boehringer Ingelheim
Completed
Development of Assessment Method for Driving Ability Using Driving Simulator in Healthy Volunteers #1

Condition: Healthy Participants
Interventions: Other: Road-tracking test; Other: Car-following test; Other: Harsh-braking test
Sponsors: Taisho Pharmaceutical Co., Ltd.; Nagoya University
Completed
Growth of Healthy Term Infants Fed a Partially Hydrolyzed Follow-up Formula

Condition: Growth
Intervention: Other: Formula feeding regimen
Sponsors: Nestlé; Biofortis Mérieux NutriSciences
Recruiting
Single and Multiple-Ascending Dose Study of CRN00808 in Healthy Volunteers

Condition: Healthy Volunteers
Interventions: Drug: CRN00808; Drug: Placebo Oral Solution; Drug: Midazolam oral solution; Drug: Placebo oral capsule
Sponsor: Crinetics Pharmaceuticals Inc.
Completed
Pharmacokinetic, Safety and Tolerability Study of Altebrel in Healthy Male Subjects

Conditions: Phase 1; Bioequivalence
Intervention: Drug: Etanercept
Sponsor: AryoGen Pharmed Co.
Completed
A Study Of CinnoRA (Adalimumab-CinnaGen) And Adalimumab (Humira) In Healthy Subjects

Conditions: Bioequivalence; Phase 1
Intervention: Drug: Adalimumab
Sponsor: Cinnagen
Completed
A Study to Evaluate Bioequivalence and Adhesion of a Transdermal Contraceptive Patch Manufactured With Newly Sourced Adhesive Components and Currently Marketed EVRA in Healthy Adult Women

Condition: Healthy
Interventions: Drug: EVRA patch (NGMN+EE) (Treatment A) (Reference); Drug: HMW PIB patch (NGMN+EE) (Treatment B) (Test)
Sponsor: Janssen Research & Development, LLC
Completed
A Study to Assess Immune Response to Multiple Doses of PF-06881894 or US-Approved Neulasta in Healthy Volunteers

Condition: Healthy Volunteers
Interventions: Biological: PF-06881894; Biological: US-approved Neulasta
Sponsor: Pfizer
Completed
A Study of Lasmiditan and Propranolol in Healthy Participants

Condition: Healthy
Interventions: Drug: Lasmiditan; Drug: Propranolol
Sponsor: Eli Lilly and Company
Completed
Safety and Effectiveness of BPL HRIG With Active Rabies Vaccine in Healthy Subjects

Condition: Healthy
Intervention: Drug: HRIG
Sponsor: Bio Products Laboratory
Active, not recruiting
Effect of Itraconazole on the Pharmacokinetics of Bardoxolone Methyl in Healthy Adults

Condition: Healthy Volunteers
Interventions: Drug: Bardoxolone methyl capsules 10 mg; Drug: Itraconazole capsules 100 mg
Sponsor: Reata Pharmaceuticals, Inc.
Completed
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of IONIS-PKK-LRx Administered Subcutaneously to Healthy Volunteers

Condition: Healthy Volunteers
Interventions: Drug: Placebo; Drug: IONIS PKK-LRx
Sponsor: Ionis Pharmaceuticals, Inc.
Active, not recruiting
First-in-Human Trial of Single Ascending Dose, Multiple Ascending Dose and Malaria Challenge Model in Healthy Subjects

Condition: Healthy
Interventions: Drug: M5717; Drug: Placebo
Sponsor: Merck KGaA
Recruiting
Phase I Study of Pyrimethamine in Healthy Japanese and Caucasian Subjects

Condition: Toxoplasmosis
Interventions: Drug: Pyrimethamine; Drug: Calcium folinate
Sponsor: GlaxoSmithKline
Completed
Feasibility and Implementation of a Healthy Lifestyles Program

Conditions: Health Behavior; Quality of Life; Chronic Disease; Health Promotion; Stress; Mental Health Wellness 1
Interventions: Behavioral: Health and wellness learning sessions; Behavioral: Brainstorming group sessions; Behavioral: Individual sessions with a multidisciplinary health team; Behavioral: Health goal development; Behavioral: Physical activity and nutrition journals
Sponsor: McMaster University
Active, not recruiting
A Study of Crisaborole Ointment 2% in Adult Japanese Healthy Subjects and Adult Japanese Subjects With Mild To Moderate Atopic Dermatitis

Conditions: Healthy; Atopic Dermatitis
Interventions: Drug: Crisaborole ointment 2%; Drug: Vehicle
Sponsor: Pfizer
Completed
This Study Tests BI 685509 in Healthy Chinese and Japanese Men; the Study Tests How Different Doses of BI 685509 Are Taken up in the Body and How Well They Are Tolerated

Condition: Healthy
Interventions: Drug: BI 685509; Drug: Placebo
Sponsor: Boehringer Ingelheim
Completed
Altering the Availability of Healthier vs. Less Healthy Items in Vending Machines

Condition: Healthy Diet
Intervention: Behavioral: Availability of healthier vs. less healthy foods
Sponsors: University of Cambridge; Oxford University Hospitals NHS Foundations Trust
Completed
Effects of Enriched Fruit Juice on Blood Glucose Levels After a Meal in Healthy Subjects

Conditions: Hyperglycemia, Postprandial; Healthy
Interventions: Dietary Supplement: Enriched pomegranate juice; Dietary Supplement: Placebo beverage
Sponsor: University of Leeds
Recruiting
Interhemispheric Interaction of Parieto-Motor Cortico-Cortical Plasticity

Condition: Healthy Volunteers
Intervention:
Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting
Technical Development of Clinical Laboratory Studies

Condition: Healthy Volunteers
Intervention:
Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting
Safety and Immunogenicity of MSB11455 in Healthy Subjects

Condition: Healthy
Interventions: Drug: MSB11455; Drug: Neulasta
Sponsor: Merck KGaA
Active, not recruiting
Pharmacokinetic/Pharmacodynamic Equivalence of MSB11455 in Healthy Subjects

Condition: Healthy
Interventions: Drug: MSB11455; Drug: Neulasta
Sponsor: Merck KGaA
Active, not recruiting
Clinical Study to Evaluate the Pharmacokinetics, Safety, Tolerability and Pharmacodynamic Effects of a Single and Multiple Oral BAY1101042 Tablet Doses in Healthy Male Subjects

Condition: Healthy Volunteer
Interventions: Drug: BAY1101042; Drug: Placebo
Sponsor: Bayer
Recruiting
Study Designed to Assess the Safety, Tolerability and PK of PTI-808 in Healthy Volunteers and in Adults With Cystic Fibrosis

Conditions: Healthy Volunteer - Complete; Cystic Fibrosis
Interventions: Drug: PTI-808; Drug: Placebo; Drug: PTI-428; Drug: PTI-801
Sponsor: Proteostasis Therapeutics, Inc.
Recruiting
Levomilnacipran in Healthy Males

Condition: None (i.e. Healthy Volunteers)
Interventions: Drug: Levomilnacipran; Drug: Duloxetine; Drug: Placebos
Sponsors: University of Ottawa; Allergan
Recruiting
A Study to Evaluate the Effect of Multiple Oral Doses of JNJ-42847922 on the Steady-state Pharmacokinetics of an Oral Contraceptive Containing Ethinyl Estradiol and Levonorgestrel in Healthy Female Adult Participants

Condition: Healthy
Interventions: Drug: Ethinyl Estradiol + Levonorgestrel; Drug: JNJ‑42847922
Sponsor: Janssen-Cilag International NV
Completed
To Demonstrate Similarity of Pharmacokinetics and Evaluate Safety of CT-P16, EU-Approved Avastin and US-licensed Avastin

Condition: Healthy
Interventions: Drug: CT-P16; Drug: EU-approved Avastin; Drug: US-licensed Avastin
Sponsor: Celltrion
Completed
A Study in Healthy Male Subjects to Investigate Whether Administration of ACT-132577 Can Affect Rosuvastatin's Fate in the Body (Amount and Time of Presence in the Blood)

Condition: Healthy Subjects
Interventions: Drug: ACT-132577; Drug: Rosuvastatin
Sponsor: Idorsia Pharmaceuticals Ltd.
Completed
Multicultural Healthy Diet to Reduce Cognitive Decline

Conditions: Diet Modification; Cognitive Decline; Cognitive Change
Interventions: Other: Multicultural Healthy Diet; Other: Usual Diet plus Self-Care
Sponsors: Albert Einstein College of Medicine, Inc.; Penn State University; University of Pennsylvania; University of Minnesota - Clinical and Translational Science Institute; National Institute on Aging (NIA)
Recruiting
Investigation of Thermal Injury on Intestinal Permeability in Both Thermal Injury and Healthy Participants

Condition: Burns
Interventions: Other: Lactulose and Mannitol solution; Other: Sucralose
Sponsor: GlaxoSmithKline
Completed
A Multiple-Dose Study of Intravenous BNZ132‑1-40 in Healthy Adult Subjects

Condition: Safety and Tolerability in Healthy Subjects
Interventions: Drug: BNZ132-1-40; Drug: Placebo
Sponsors: Bioniz Therapeutics; Celerion
Completed
Study to Evaluate the Pharmacokinetics of a New Tablet Formulation of CPI-444 in Fed and Fasted Healthy Male and Female Subjects

Condition: Healthy Subjects
Interventions: Drug: CPI-444 Capsules; Drug: CPI-444 Tablets
Sponsor: Corvus Pharmaceuticals, Inc.
Completed
A Phase 1 Study to Evaluate the Safety and Pharmacokinetics of Entecavir Extended Release (XR) in Healthy Subjects

Condition: HBV
Intervention: Drug: Entecavir
Sponsor: Aucta Pharmaceuticals, Inc
Completed
Safety and Pharmacokinetic Study of PF-06700841 in Japanese Healthy Volunteers

Condition: Healthy
Interventions: Drug: PF-06700841; Drug: Placebo
Sponsor: Pfizer
Completed
Relative Bioavailability of Gantenerumab Produced by G4 Process Versus G3 Process Following Subcutaneous (SC) Injection in Healthy Participants

Condition: Healthy Participants
Intervention: Drug: Gantenerumab
Sponsor: Hoffmann-La Roche
Completed
Phase 1 TAK-906 Single and Multiple Ascending Dose Study in Japanese Healthy Male Subjects

Condition: Japanese Healthy Adult Male Participants
Interventions: Drug: TAK-906; Drug: TAK-906 Placebo
Sponsor: Takeda
Completed
Study of Safety and Drug Levels of CCI15106 Inhalation Powder in Healthy Adults and Adults With Moderate Chronic Obstructive Pulmonary Disease. Study of CCI15106 Levels in People Standing Near the Person Inhaling the Drug

Condition: Pulmonary Disease, Chronic Obstructive
Interventions: Drug: CCI15106; Drug: Placebo
Sponsor: GlaxoSmithKline
Completed
Constitution of a Biological Cohort Following Bone Marrow Sampling From MDS or AML Patients and Age-matched Healthy Donors

Conditions: Myelodysplastic Syndromes; Acute Myeloid Leukemia; Cardio-vascular Surgery
Intervention: Other: Bone marrow analyses
Sponsors: Institut de Cancérologie de la Loire; Centre Hospitalier Universitaire de Saint Etienne
Recruiting
Safety and Pharmacokinetic Study of PF-06651600 in Japanese Healthy Volunteers

Condition: Healthy
Interventions: Drug: PF-06651600; Drug: Placebo
Sponsor: Pfizer
Completed
This Study Tests How Healthy Men Tolerate Different Doses of BI1015550. The Study Also Tests How BI 1015550 is Taken up by the Body

Condition: Healthy
Interventions: Drug: BI 1015550; Drug: Placebo
Sponsor: Boehringer Ingelheim
Completed
A Study To Assess The Safety, Tolerability, And Pharmacokinetics (PK) Of Multiple Doses Of PF-06865571 In Healthy, Including Overweight And Obese, Adult Subjects

Condition: Healthy Subjects
Interventions: Drug: PF-06865571; Drug: Placebo
Sponsor: Pfizer
Completed
Safety, Tolerability & Pharmacokinetics of LEVI-04 in Healthy Volunteers and Patients With Osteoarthritis Knee Pain

Conditions: Healthy Volunteers; Osteoarthritis
Interventions: Drug: LEVI-04; Drug: Placebo
Sponsors: Levicept; Hammersmith Medicines Research
Recruiting
A Study to Evaluate Safety, Tolerability and Pharmacokinetics of Ascending Oral Single Dose of TAK-418 in Healthy Participants

Condition: Healthy Participants
Interventions: Drug: TAK-418; Drug: TAK-418 Placebo
Sponsor: Takeda
Completed
First-in-Human Trial of Anti-ADAMTS-5 Nanobody in Healthy Volunteers

Condition: Healthy
Interventions: Drug: M6495; Drug: Placebo
Sponsor: Merck KGaA
Completed
A Study to Evaluate Safety, Tolerability, and Pharmacokinetics of Escalating Multiple Doses of TAK-831 in Healthy Participants

Condition: Healthy
Interventions: Drug: TAK-831; Drug: Placebo
Sponsor: Takeda
Completed
Safety, Tolerability, and Pharmacokinetics of Single Doses of BIIB059 in Healthy Japanese Subjects.

Condition: Healthy Subjects
Interventions: Drug: BIIB059; Drug: Placebo
Sponsor: Biogen
Completed
Comparison of ALD, NASH, and Healthy Control Patients

Condition: ALD - Alcoholic Liver Disease
Intervention: Other: Blood draw
Sponsor: The Cleveland Clinic
Recruiting
Bioequivalence Study of Xian Risperdal Tablets Compared With Gurabo Risperdal Tablets Under Fasting and Fed Conditions in Chinese Healthy Participants

Condition: Healthy
Interventions: Drug: Risperidone: Xian Risperdal (test); Drug: Risperidone: Gurabo Risperdal (reference)
Sponsor: Xian-Janssen Pharmaceutical Ltd.
Withdrawn
A Study of LY3314814 in Healthy Participants

Condition: Healthy
Interventions: Drug: LY3314814; Drug: [13C415N3] LY3314814
Sponsors: Eli Lilly and Company; AstraZeneca
Completed
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7049665 in Healthy Volunteers

Condition: Healthy Volunteers
Interventions: Biological: RO7049665; Biological: Placebo
Sponsor: Hoffmann-La Roche
Active, not recruiting
A Study to Assess the Amount of LY3074828 That Gets Into the Body When Given With LY9999QS, in Healthy Participants

Condition: Healthy
Interventions: Biological: LY3074828; Biological: LY900021
Sponsor: Eli Lilly and Company
Completed
Glymphatic Kinetics In Healthy Adult Volunteers

Condition: Healthy
Interventions: Other: MR Imaging; Other: CT-guidance
Sponsors: Weill Medical College of Cornell University; Biogen
Completed
AZD1390 Administration of a Microdose [11C]AZD1390 to Healthy Volunteers

Condition: Healthy Volunteer Male Subjects
Intervention: Drug: [11C]AZD1390
Sponsors: AstraZeneca; Karolinska Institutet, Quintiles IMS
Completed
A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Single Doses of PF-06852231 in Healthy Subjects

Condition: Healthy Volunteers
Interventions: Drug: Placebo; Drug: PF-06852231
Sponsor: Pfizer
Completed
The Purpose of the Study is to Compare Two Fixed Dose Combination Tablets of Dapagliflozin/Metformin XR in Healthy Subjects Under Fasting and Fed Conditions

Condition: Healthy Subjects in Fasted and Fed State
Interventions: Drug: Dapagliflozin/metformin XR 5/500mg; Drug: Dapagliflozin/metformin XR 5/500 mg; Drug: Dapagliflozin/metformin XR 10/1000mg
Sponsor: AstraZeneca
Completed
Double-Blind Randomized Controlled Trial for the Evaluation of a Novel Adaptive Attention Training in Healthy Adolescents

Condition: Healthy Adolescents
Interventions: Behavioral: Adaptive Attention Training; Behavioral: Active Control; Behavioral: Low-dose Adaptive Attention Training
Sponsors: University of California, San Francisco; How I Decide Foundation
Not yet recruiting
A Study of Baricitinib in Healthy Participants

Condition: Healthy
Interventions: Drug: Baricitinib suspension; Drug: Baricitinib tablet
Sponsor: Eli Lilly and Company
Completed
This Study in Healthy Men Tests How Different Doses of BI 1358894 Are Taken up in the Body and How Well They Are Tolerated. The Study Also Looks at How Food Influences the Amount of BI 1358894 in the Blood

Condition: Healthy
Interventions: Drug: Placebo; Drug: BI 1358894; Drug: BI 1358894 (Test); Drug: BI 1358894 (Reference)
Sponsor: Boehringer Ingelheim
Recruiting
Collection of Immunology Specimens From Patients With Cancer or Blood Disorders, and Healthy Volunteers

Conditions: Healthy Subject; Hematologic and Lymphocytic Disorder; Hematopoietic and Lymphoid Cell Neoplasm; Immune System Disorder; Malignant Neoplasm
Interventions: Procedure: Biospecimen Collection; Other: Laboratory Biomarker Analysis; Other: Questionnaire Administration
Sponsors: University of Southern California; National Cancer Institute (NCI)
Recruiting
Effects of a High-CML Diet on Absorption and Excretion Levels in Healthy Adults

Condition: Healthy
Interventions: Other: High-CML diet; Other: Low-CML diet
Sponsor: Universidad de Guanajuato
Completed
An Open Study to Assess the Safety and Pharmacokinetics of Fluorothyazinone as a Single-Dose Administration or a Treatment Course in Healthy Volunteers

Condition: Healthy Volunteer
Interventions: Drug: Fluorothyazinone 300 mg; Drug: Fluorothyazinone 600 mg; Drug: Fluorothyazinone 3900 mg
Sponsors: Gamaleya Research Institute of Epidemiology and Microbiology, Health Ministry of the Russian Federation; Center of Pharmaceutical Analytics
Completed
This Study is Done in Healthy Chinese and Japanese Volunteers; it Looks at How BI 690517 is Taken up in the Body and How Well it is Tolerated

Condition: Healthy
Interventions: Drug: BI 690517; Drug: Placebo
Sponsor: Boehringer Ingelheim
Completed
Study Comparing TPI-120 and Neulasta Administered Through Subcutaneous Route in Healthy Adult Subjects

Condition: Healthy Volunteers
Interventions: Drug: PEG-rhG-CSF; Drug: Neulasta (PEG-rhG-CSF)
Sponsors: Adello Biologics, LLC; inVentiv Health Clinical
Completed
Comparative Immunogenicity Study Comparing TPI-120 to Neulasta® in Healthy Adult Subjects

Condition: Healthy Volunteers
Intervention: Drug: PEGFILGRASTIM
Sponsors: Adello Biologics, LLC; Celerion
Completed
A Study of the Safety, Tolerability, and Absorption, Metabolism, and Excretion of PA-824 in Healthy Adult Male Subjects.

Condition: Tuberculosis
Intervention: Drug: PA-824
Sponsor: Global Alliance for TB Drug Development
Completed
Reaching Latino Family Dyads to Increase Physical Activity and Healthy Eating

Condition: Cancer Prevention
Interventions: Behavioral: Immersive Assessment; Behavioral: Household Food Inventory (HFI); Device: Accelerometer; Behavioral: Questionnaires; Behavioral: Interviews
Sponsors: M.D. Anderson Cancer Center; National Heart, Lung, and Blood Institute (NHLBI)
Active, not recruiting
Frontopolar Cortex and Motivation in Healthy Older Adults

Condition: Motivation in Healthy Older Adults
Intervention: Device: transcranial direct current stimulation
Sponsor: University of Zurich
Recruiting
Healthy Adolescent Transitions (HAT)

Conditions: Pregnancy Prevention; Life Skill Development
Intervention: Behavioral: Healthy Adolescent Transitions (HAT) program
Sponsors: Jack Stevens; OhioHealth Research and Innovation Institute
Recruiting
Evaluation of Safety and Tolerability of Single Rising Doses of BI 473494 in Healthy Subjects

Condition: Healthy
Interventions: Drug: BI 473494; Drug: Placebo
Sponsor: Boehringer Ingelheim
Suspended
A Study to Assess the Bioequivalence of Xisimin (Loratadine) Tablets Under Fasting and Fed Conditions in Healthy Participants Compared With Clarityne Tablets

Condition: Healthy
Interventions: Drug: Loratadine (Xisimin [Test Treatment]); Drug: Loratadine (Clarityne [Reference Treatment])
Sponsor: Xian-Janssen Pharmaceutical Ltd.
Completed
A Study Designed to Compare the Safety and Pharmacokinetics of Intravenously Administered Superoxide Dismutase Mimetic GC4711 and GC4419 in Healthy Volunteers

Conditions: Healthy Volunteers; Healthy
Interventions: Drug: GC4711 30 mg IV; Drug: GC4711 50 mg IV; Drug: GC4419 45 mg IV
Sponsors: Galera Therapeutics, Inc.; INC Research
Completed
In Vivo Predictive Dissolution 1

Condition: Healthy
Intervention: Diagnostic Test: MRI and concomitant perfused manometry of bowel motility
Sponsors: University of Nottingham; Food and Drug Administration U.S. Award #HHSF223201510157C; University of Michigan
Active, not recruiting
A Study to Evaluate the Pharmacokinetics of Entinostat in Adult Subjects With Normal and Impaired Renal Function

Conditions: Renal Impairment; Healthy Volunteer
Intervention: Drug: Entinostat
Sponsor: Syndax Pharmaceuticals
Completed
This Study Tests in Healthy Korean Women Which Effects BI 409306 and a Birth-control Pill Have on Each Other

Condition: Healthy
Interventions: Drug: Microgynon; Drug: BI 409306
Sponsor: Boehringer Ingelheim
Completed
A Study to Examine the Effects of Entinostat on Midazolam in Healthy Adult Subjects

Conditions: Drug Interaction; Healthy Volunteer
Interventions: Drug: Entinostat; Drug: Midazolam
Sponsor: Syndax Pharmaceuticals
Completed
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of GDC-0853 in Healthy Japanese and Caucasian Participants

Condition: Healthy Volunteer
Interventions: Drug: GDC-0853; Drug: Placebo
Sponsor: Hoffmann-La Roche
Completed
Safety, Tolerability and Pharmacokinetics (PK) Study of GSK2269557 in Healthy Subjects

Condition: Pulmonary Disease, Chronic Obstructive
Interventions: Drug: GSK2269557 500 µg; Drug: GSK2269557 750 µg
Sponsor: GlaxoSmithKline
Completed
Healthy Frio: A Rural Community Partnership to Advance Latino Obesity Research

Conditions: Obesity; Nutrition Poor; Physical Activity; Weight Loss
Interventions: Behavioral: Healthy Frio In-Person Family-focused Intervention; Behavioral: Healthy Frio Remote Technology Family-focused Intervention; Behavioral: Control
Sponsors: University of Texas at Austin; The University of Texas at San Antonio; The University of Texas Health Science Center at San Antonio; University of Maryland
Recruiting
Study to Evaluate the Safety and Tolerability of ASP8062 in Healthy Japanese Male and Female Subjects

Condition: Healthy Volunteers
Interventions: Drug: ASP8062; Drug: Placebo
Sponsor: Astellas Pharma Inc
Completed
Neurophysiological Study of Sensory and Cognitive Processes in Healthy Children and Adults

Condition: Healthy Volunteer
Interventions: Behavioral: Neurophysiological assessment; Behavioral: Neuropsychological assessment
Sponsor: University Hospital, Tours
Recruiting
Effects of Whole Body Vibration on Autonomic Function in Healthy Young and Elderly

Conditions: Healthy; Aging
Intervention: Other: Whole Body Vibration
Sponsor: Universidade Federal de Pernambuco
Completed
A Study to Investigate the Intrapulmonary Lung Penetration of Nacubactam in Healthy Participants

Condition: Gram-negative Bacterial Infections
Interventions: Drug: nacubactam; Drug: meropenem
Sponsor: Hoffmann-La Roche
Completed
A Study to Investigate Safety and Tolerability, Pharmacokinetics and Pharmacodynamics of JNJ-64140284 in Healthy Participants

Condition: Healthy
Interventions: Drug: JNJ-64140284 0.1 mg; Drug: JNJ-64140284 0.5 mg; Drug: JNJ-64140284 2.5 mg; Drug: JNJ-64140284 10 mg; Drug: JNJ-64140284 50 mg; Drug: JNJ-64140284 150 mg; Drug: JNJ-64140284 (dose to be determined [TBD]); Drug: Placebo
Sponsor: Janssen Research & Development, LLC
Terminated
Study to Assess Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of BI 456906 in Healthy Male Volunteers

Condition: Healthy
Interventions: Drug: BI 456906; Drug: Placebo
Sponsor: Boehringer Ingelheim
Completed
A Study Conducted in Healthy Male Subjects to Investigate the Safety and Tolerability of AC-76, Its Fate in the Body, and Its Effect on the Body

Condition: Healthy Subjects
Interventions: Drug: AC-076 for s.c. administration; Drug: Placebo
Sponsor: Idorsia Pharmaceuticals Ltd.
Completed
Healthy Lung Study- Development of 3 Tesla MRI Hardware and Software for Helium-3 Gas Imaging of the Lung: Healthy Volunteer Development Study

Condition: Healthy Volunteers
Intervention: Diagnostic Test: Hyperpolarized Helium 3 Magnetic Resonance Imaging
Sponsors: Western University, Canada; London Health Sciences Centre
Recruiting
Caplacizumab Single and Multiple Dose Study in Healthy Japanese and White Subjects.

Condition: Healthy Volunteers
Interventions: Biological: Caplacizumab Dose 1 iv (single-dose); Biological: Caplacizumab Dose 2 iv (single-dose); Biological: Caplacizumab Dose 2 sc (single-dose); Biological: Caplacizumab Dose 2 sc (multiple-dose); Other: Placebo iv (single-dose); Other: Placebo sc (single-dose); Other: Placebo sc (multiple-dose)
Sponsor: Ablynx
Completed
Study to Evaluate Safety and Tolerability of ACT-709478 in Healthy Subjects

Condition: Healthy Subjects
Interventions: Drug: ACT-709478; Drug: Placebo
Sponsor: Idorsia Pharmaceuticals Ltd.
Recruiting
A Phase 1, Randomized, Placebo-and Positive-Controlled Crossover Study to Determine the Effect of Single-Dose GC4419 on QTc Interval in Healthy Volunteers

Conditions: Healthy Volunteers; Healthy
Interventions: Drug: GC4419 IV; Drug: Placebo; Drug: Oral moxifloxacin
Sponsors: Galera Therapeutics, Inc.; INC Research
Completed
A Phase 1 Study To Evaluate The Effect Of Glasdegib On The Cardiac Repolarization In Healthy Subjects

Condition: Healthy Volunteers
Interventions: Drug: Glasdegib Therapeutic Exposure; Drug: Glasdegib Supra-therapeutic Exposure; Drug: Positive Control (Moxifloxacin); Other: Placebo Control
Sponsor: Pfizer
Completed
A Study to Investigate the Absorption, Metabolism, Excretion, and Mass Balance of GC4419 in Healthy Adult Subjects

Conditions: Healthy Volunteers; Healthy
Intervention: Drug: GC4419
Sponsors: Galera Therapeutics, Inc.; Celerion
Completed
Enhancing Knowledge Translation in Nutrition Through a Healthy Eating Blog

Condition: Healthy
Intervention: Behavioral: Healthy eating blog
Sponsor: Laval University
Completed
Alabama Community Healthy Marriage Initiative Evaluation Project for Couples

Conditions: Healthy Marriage; Healthy Relationship
Interventions: Behavioral: Couples Connecting Mindfully; Behavioral: ELEVATE
Sponsors: Auburn University; Mathematica Policy Research, Inc.; Department of Health and Human Services
Active, not recruiting
This Study Tests BI 1467335 in Healthy Japanese and Caucasian Men. The Study Tests How Different Doses of BI 1467335 Are Taken up in the Body and How Well They Are Tolerated

Condition: Healthy
Interventions: Drug: BI 1467335; Drug: Placebo
Sponsor: Boehringer Ingelheim
Completed
A Study of KY1005 in Healthy Volunteers

Condition: Immune System Diseases
Interventions: Drug: KY1005; Drug: Placebo
Sponsor: Kymab Limited
Completed
A Clinical Study to Investigate How Safe and Tolerable the Study Drug MT-2990 is and How MT-2990 is Taken up by the Body in Healthy Volunteers

Condition: Healthy
Interventions: Drug: MT-2990; Drug: Placebo
Sponsor: Mitsubishi Tanabe Pharma Corporation
Completed
A Study to Evaluate the Cardiac Safety of a Single Dose of AL-335 Administered on a Background of Simeprevir and Odalasvir and of Repeated Doses of Odalasvir Administered Alone in Healthy Participants

Condition: Healthy
Interventions: Drug: ODV Placebo (Matching 25 mg ODV); Drug: ODV Placebo (Matching 200 mg ODV); Drug: ODV Placebo (Matching 125 mg ODV); Drug: ODV Placebo (Matching 100 mg ODV); Drug: SMV Placebo (Matching 150 mg SMV); Drug: AL-335 Placebo (matching 1200 mg AL-335); Drug: Moxifloxacin Placebo (matching 400 mg moxifloxacin); Drug: ODV 25 mg; Drug: ODV 200 mg; Drug: ODV 125 mg; Drug: ODV 100 mg; Drug: SMV 150 mg; Drug: AL-335 1200 mg
Sponsor: Janssen Research & Development, LLC
Completed
A Study Evaluating Good Idea on Glucose Homeostasis in a Healthy Population

Condition: Healthy
Interventions: Dietary Supplement: GoodIdea; Other: Placebo
Sponsors: DoubleGood AB; KGK Science Inc.
Completed
A Study of LY3002815 in Healthy Participants

Condition: Healthy
Interventions: Drug: LY3002815; Drug: Placebo
Sponsor: Eli Lilly and Company
Active, not recruiting
A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of JNJ-55308942 in Healthy Male and Female Participants

Condition: Healthy
Interventions: Drug: JNJ-55308942 0.5 mg; Drug: JNJ-55308942 1.5 mg; Drug: JNJ-55308942 4 mg; Drug: JNJ-55308942 12 mg; Drug: JNJ-55308942 36 mg; Drug: JNJ-55308942 100 mg; Drug: JNJ-55308942: Fed State; Drug: JNJ-55308942: MAD Part; Drug: Placebo
Sponsor: Janssen-Cilag International NV
Completed
Determination the Abuse Potential of Pitolisant in Healthy, Non-Dependent Recreational Stimulant Users

Conditions: Healthy; Drug Abuse
Interventions: Drug: Pitolisant; Drug: Placebos; Drug: Phentermine
Sponsor: Bioprojet
Completed
Study of Evinacumab (REGN1500) in Caucasian and in Japanese Healthy Volunteers

Condition: Healthy Volunteers
Interventions: Drug: Evinacumab; Drug: Placebo
Sponsor: Regeneron Pharmaceuticals
Completed
Assessment of the Biodistribution and Safety of [18F]MNI-968 in Healthy Subjects

Condition: Healthy Volunteers
Intervention: Drug: [18F]MNI-968
Sponsor: Molecular NeuroImaging
Completed
Effects of TS-134 on Ketamine-induced BOLD Signals in Healthy Subjects

Condition: Healthy Volunteers
Interventions: Drug: TS-134; Drug: Placebo; Other: Ketamine
Sponsor: Taisho Pharmaceutical R&D Inc.
Completed
Community-Based Continence Promotion: Sustaining Healthy Aging in Place (SHAIP) Through Mind Over Matter (MOM)

Conditions: Fecal Incontinence in Old Age; Urinary Incontinence in Old Age
Intervention: Behavioral: Mind Over Matter; Healthy Bowels, Healthy Bladder
Sponsors: University of Wisconsin, Madison; Wisconsin Partnership Program
Completed
A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of JNJ-61803534 and to Evaluate the Effect of JNJ-61803534 on the Pharmacokinetics of Midazolam in Healthy Participants

Condition: Healthy
Interventions: Drug: JNJ-61803534; Drug: Placebo; Drug: Midazolam
Sponsor: Janssen Research & Development, LLC
Terminated
Study Assessing the Safety, Tolerability, Pharmacokinetics, Food Effect, and Drug-Drug Interactions of PTI-801 in Healthy Volunteers, and Safety, Tolerability, and Pharmacokinetics of PTI-801 in Subjects With Cystic Fibrosis

Conditions: Healthy Volunteer - Complete; Cystic Fibrosis
Interventions: Drug: PTI-801; Drug: Placebo; Drug: PTI-808
Sponsor: Proteostasis Therapeutics, Inc.
Recruiting
Healthy Combine Study

Condition: Healthy
Interventions: Drug: Nicotinamide; Drug: Lanthanum Carbonate; Drug: Lanthanum Carbonate Placebo; Drug: Nicotinamide Placebo
Sponsor: Northwestern University
Completed
Bioequivalence Study of Combination Tablets of Saxagliptin / Dapagliflozin / Metformin XR (Extended-release) and Dapagliflozin / Metformin XR Relative to Individual Components in Healthy Subjects

Condition: Type 2 Diabetes Mellitus
Interventions: Drug: 2.5 mg saxagliptin / 5 mg dapagliflozin / 850 mg metformin XR FDC tablet; Drug: 2.5 mg saxagliptin / 5 mg dapagliflozin / 1000 mg metformin XR FDC tablet; Drug: 5 mg dapagliflozin / 850 mg metformin XR FDC; Drug: 5 mg dapagliflozin / 1000 mg metformin XR FDC; Drug: 2.5 mg ONGLYZA® (saxagliptin) tablet; Drug: 5 mg Forxiga® (dapagliflozin) tablet; Drug: 500 mg Glucophage XR®
Sponsor: AstraZeneca
Completed
Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AJM347 in Healthy Male Caucasian and Japanese Subjects in the Fasted and Fed State

Condition: Healthy Participants
Interventions: Drug: AJM347; Drug: Placebo
Sponsor: EA Pharma Co., Ltd.
Completed
A Study to Assess Safety, Tolerability and Pharmacokinetics of GLPG3067 in Healthy Subjects.

Condition: Healthy
Interventions: Drug: GLPG3067 single dose; Drug: Placebo single dose; Drug: GLPG3067 multiple dose; Drug: Placebo multiple dose; Drug: GLPG3067 oral suspension; Drug: GLPG3067 oral tablet; Drug: GLPG3067/GLPG2222 multiple dose; Drug: GLPG3067/GLPG2222 Placebo multiple dose; Drug: GLPG3067/GLPG2222/GLPG2737 multiple dose; Drug: GLPG3067/GLPG2222/GLPG2737 Placebo multiple dose
Sponsor: Galapagos NV
Completed
A Study to Investigate the Effect of Different Particle Sizes on the Single-dose Pharmacokinetics of Rilpivirine After Intramuscular Injection of a Long-acting Nanosuspension in Healthy Participants

Condition: Healthy
Interventions: Drug: Rilpivirine; Drug: Rilpivirine Long-acting Parenteral Formulation
Sponsor: Janssen Research & Development, LLC
Completed
Safety and Pharmacokinetics of Single Rising Doses of BI 705564 and Food Effect on BI 705564 in Healthy Male Subjects

Condition: Healthy
Interventions: Drug: Placebo; Drug: BI 705564; Drug: BI 705564 (Test); Drug: BI 705564 (Reference)
Sponsor: Boehringer Ingelheim
Completed
Normal Breathing and Swallowing in Healthy Volunteers

Condition: Healthy
Interventions: Drug: Capsaicin; Device: Videofluoroscopic swallow study
Sponsor: University of Florida
Recruiting
Single Rising Dose Trial of BI 655130 for Healthy Japanese Male Subjects

Condition: Healthy
Interventions: Drug: BI 655130; Drug: Placebo
Sponsor: Boehringer Ingelheim
Completed
A Study to Evaluate the Pharmacokinetics (PK) of Darunavir (DRV) and Cobicistat (COBI) After a Single Oral Administration of Darunavir/Cobicistat Fixed-Dose Combination in Healthy Japanese Adult Participants

Condition: Healthy
Intervention: Drug: Darunavir/Cobicistat
Sponsor: Janssen Pharmaceutical K.K.
Completed
A Study To Estimate The Effects Of Itraconazole On Pharmacokinetics Of Pf-06649751 In Healthy Adult Subjects

Condition: Healthy
Intervention: Drug: PF06649751, Itraconazole
Sponsor: Pfizer
Completed
Safety and Tolerability of BI 685509 in Healthy Subjects

Condition: Healthy
Interventions: Drug: BI 685509; Drug: Placebo
Sponsor: Boehringer Ingelheim
Completed
Lung Ultrasound in High Altitude Lung Edema

Condition: Pulmonary Edema
Intervention: Diagnostic Test: lung ultrasound
Sponsor: Medical University of Vienna
Completed
A Phase I [18F]THK-5351 Positron Emission Tomography Study in Healthy Subjects and Alzheimer's Disease

Condition: Alzheimer Disease
Intervention: Drug: [18F]THK-5351
Sponsor: Asan Foundation
Recruiting
Collection and Generation of Antigen-specific T-lymphocyte Cell Lines From Primary, Third-party, Related, and Unrelated Donors

Condition: Healthy
Intervention: Other: Leukapheresis
Sponsor: Memorial Sloan Kettering Cancer Center
Recruiting
Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of REGN3918 in Healthy Volunteers

Condition: Healthy Volunteers
Interventions: Drug: REGN3918; Drug: Placebo
Sponsor: Regeneron Pharmaceuticals
Completed
PK Study in Adult Healthy Volunteers to Assess QD Dosing With the Selected Age-appropriate MR Formulations

Condition: Healthy
Intervention: Drug: 10 mg dose MR formulations,10 mg dose of tofacitinib IR solution
Sponsor: Pfizer
Completed
Magnetic Resonance Spectroscopy Studies of Acute Hypoxic and Hyperoxic Breathing in Healthy Volunteers

Condition: Healthy
Interventions: Other: 16% O2 gas in breathed air; Other: 26% O2 gas in breathed air
Sponsor: Mclean Hospital
Not yet recruiting
The URT and Middle Ear Microbiota in Health and During Chronic OME

Conditions: Otitis Media With Effusion; Healthy
Intervention: Other: Collection of body fluids/swabs
Sponsor: University Hospital, Antwerp
Recruiting
A Study to Assess the Safety, Tolerability and Pharmacokinetics of ASP7713 in Healthy Non-Japanese Adult and Elderly Subjects and Healthy Japanese Adult Subjects

Condition: Healthy Volunteers
Interventions: Drug: ASP7713; Drug: Placebo
Sponsor: Astellas Pharma Europe B.V.
Completed
Phosphorus Absorption in Healthy Adults and in Patients With Moderate Chronic Kidney Disease

Condition: Chronic Kidney Disease Mineral and Bone Disorder
Intervention: Other: Phosphorus Absorption Test
Sponsor: Purdue University
Recruiting
A Phase 1 Study to Evaluate the Effect of the Organic Anion Transporter Inhibitor Probenecid on the Pharmacokinetics of JNJ-64041575 in Healthy Adults

Condition: Healthy
Interventions: Drug: JNJ-64041575; Drug: Probenecid
Sponsor: Janssen-Cilag International NV
Completed
TD-3504 SAD in Healthy Subjects and Subjects With Ulcerative Colitis (UC)

Condition: Active Mild Ulcerative Colitis, Active Moderate Ulcerative Colitis, Healthy Subjects
Interventions: Drug: TD-3504; Drug: 15N2-tofacitinib; Drug: Placebo
Sponsor: Theravance Biopharma
Completed
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Ionis AGT-LRx in Healthy Volunteers

Condition: Healthy Volunteers
Interventions: Drug: Ionis AGT-LRx; Drug: Placebo
Sponsor: Ionis Pharmaceuticals, Inc.
Completed
This Study Tests How Different Doses of BI 690517 Are Taken up in the Body of Healthy Men. The Study Also Looks at How Food Influences the Amount of BI 690517 in the Blood

Condition: Healthy
Interventions: Drug: BI 690517; Drug: Placebo; Drug: BI 690517 (Reference)
Sponsor: Boehringer Ingelheim
Completed
A Study of ACT-541468 in Healthy Japanese and Caucasian Subjects

Condition: Healthy Subjects
Interventions: Drug: ACT-541468; Drug: placebo
Sponsor: Idorsia Pharmaceuticals Ltd.
Completed
Safety, Tolerability, and Pharmacokinetics of a Subcutaneous and Intravenous Dose of BI 655130 in Healthy Subjects

Condition: Healthy
Intervention: Drug: BI 655130
Sponsor: Boehringer Ingelheim
Completed
A Study to Evaluate ACT-132577 in Healthy Male Subjects

Condition: Healthy Subjects
Intervention: Drug: 14C-radiolabeled ACT-132577
Sponsor: Idorsia Pharmaceuticals Ltd.
Completed
A Phase 1 Study of the Safety and Pharmacokinetics of GC4711 (Oral Capsule) Compared to GC4419 (IV Infusion) in Healthy Volunteers

Condition: Healthy Volunteers
Interventions: Drug: GC4711 Oral Capsule; Drug: IV GC4419
Sponsor: Galera Therapeutics, Inc.
Recruiting
PET Study to Determine Muscarinic Receptor Occupancy in Lungs After Inhalation of AZD2115 and Tiotropium

Condition: Healthy Volunteers
Interventions: Drug: AZD2115; Drug: SPIRIVA; Radiation: [11C]AZ13754366
Sponsor: AstraZeneca
Completed
A Study of AST-008 in Healthy Subjects

Condition: Healthy Volunteer Study
Intervention: Drug: AST-008
Sponsor: Exicure, Inc.
Completed
Healthy Pregnancy Study

Conditions: Pregnancy Related; Weight Change, Body; Health Problems in Pregnancy; Behavior
Intervention:
Sponsor: Scripps Translational Science Institute
Recruiting
Phase 0 Study of [18F]MNI-968 as a Marker for D1 Receptor in Healthy Subjects

Condition: Healthy Volunteers
Intervention: Drug: [18F]MNI-968
Sponsor: Molecular NeuroImaging
Completed
Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of E6742 in Healthy Adult Subjects

Condition: Healthy Participants
Interventions: Drug: E6742; Drug: Placebo
Sponsor: Eisai Inc.
Completed
A Study to Assess the Safety, Tolerability, Pharmacokinetics, Immunogenicity, and Pharmacodynamics of JNJ-64179375 in Healthy Japanese Participants

Condition: Healthy
Interventions: Drug: JNJ-64179375 0.3 mg/kg; Drug: JNJ-64179375 1.0 mg/kg; Drug: JNJ-64179375 2.5 mg/kg; Other: Placebo; Drug: JNJ-64179375 (Dose to be Determined)
Sponsor: Janssen Research & Development, LLC
Completed
Safety and Pharmacokinetic Study of OMT-28 in Healthy Subjects

Condition: Healthy Volunteers
Interventions: Drug: OMT-28; Other: Matching Placebo
Sponsor: Omeicos Therapeutics GmbH
Completed
Relationship Education:Project Harmony

Condition: Healthy Marriage
Intervention: Behavioral: Healthy Marriage Program
Sponsors: University of Central Florida; Department of Health and Human Services
Recruiting
Safety of Prasaprohyai 95%Ethanolic Extract Capsules in Healthy Volunteer

Condition: Healthy Volunteers
Intervention: Drug: Prasaprohyai
Sponsors: Thammasat University; Thai Traditional Medical Knowledge Fund
Recruiting
Japanese Bridging Study of Ivosidenib (AG-120) in Healthy Subjects

Condition: Healthy
Intervention: Drug: ivosidenib (AG-120)
Sponsor: Agios Pharmaceuticals, Inc.
Completed
Interaction Between Trunk and Gait Performance in Both Healthy Adults and Stroke Patients

Conditions: Stroke; Healthy; Gait, Hemiplegic
Intervention:
Sponsors: Universiteit Antwerpen; Rehabilitation Hospital RevArte
Completed
Healthy Motivations for Moms-to-be Study

Conditions: Weight Gain; Pregnancy; Stress, Emotional; Exercise; Nutrition
Interventions: Behavioral: Healthy Eating and Physical Activity; Behavioral: Stress Reduction and Management
Sponsor: University of South Carolina
Completed
Health in the Right Measure: Promoting Healthy Food and Regular Physical Activity Practice for UFRJ Servers

Condition: Human
Intervention: Behavioral: Health in the right measure
Sponsor: Universidade Federal do Rio de Janeiro
Active, not recruiting
Relative Bioavailability of BMS-931699 From Prefilled Syringe Compared to Drug in Vial

Condition: Healthy
Intervention: Drug: BMS-931699
Sponsor: Bristol-Myers Squibb
Terminated
A First Time in Human Study of PIN201104 in Healthy Volunteers and Patients With Asthma

Conditions: Healthy Volunteers; Asthma
Interventions: Drug: PIN201104; Drug: Placebo
Sponsor: Peptinnovate
Completed
Search of a Paradoxical Fall in Maximum Expiratory Flow After Bronchodilation in Healthy Subjects

Condition: Paradoxical Fall in Maximum Expiratory Flows
Intervention: Drug: Inhaled Bronchodilators +/- Inhaled Methacholine
Sponsor: Assistance Publique - Hôpitaux de Paris
Recruiting
A Phase 1 Bioavailability Study of Arbaclofen Placarbil Modified Release Formulations in Healthy Volunteers

Condition: Healthy Volunteers
Interventions: Drug: Arbaclofen Placarbil SR; Drug: Arbaclofen Placarbil MR Prototype A; Drug: Arbaclofen Placarbil MR Prototype B; Drug: Arbaclofen Placarbil IR
Sponsor: Indivior Inc.
Completed
Anorectal Function and Neuronal-glial-epithelial Unit in Healthy Subjects

Condition: Healthy
Intervention: Procedure: endoscopy
Sponsor: Rennes University Hospital
Active, not recruiting
A Study of Mirikizumab (LY3074828) Injection in Healthy Participants

Condition: Healthy
Interventions: Biological: Mirikizumab Test; Biological: Mirikizumab Reference
Sponsor: Eli Lilly and Company
Completed
Dose, Safety, Tolerability and Immunogenicity of a Stabilized Prefusion RSV F Subunit Protein Vaccine, VRC-RSVRGP084-00-VP (DS-Cav1), Alone or With Alum Adjuvant, in Healthy Adults

Condition: Respiratory Syncytial Virus
Intervention: Biological: VRC-RSVRGP084-00VP
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting
Study to Evaluate Safety and PK of NTM-1634 vs Placebo Administered Intravenously in Healthy Adults

Condition: Healthy
Interventions: Drug: NTM-1634; Drug: Placebo
Sponsors: Ology Bioservices; National Institute of Allergy and Infectious Diseases (NIAID)
Completed
Development of Novel Non-invasive Inflammometry Following Lipopolysaccharide, Endotoxin (LPS) Challenge in Healthy Volunteers

Condition: Healthy
Intervention: Procedure: LPS challenge
Sponsors: Fraunhofer-Institute of Toxicology and Experimental Medicine; Hannover Medical School
Completed
Effect of Prebiotic Intake on Gut Microbiota in Healthy Adults

Condition: Healthy
Interventions: Dietary Supplement: Control; Dietary Supplement: Prebiotic
Sponsors: University of Calgary; General Mills Inc.
Active, not recruiting
A Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Risdiplam (RO7034067) in Healthy Japanese Participants

Condition: Healthy Volunteers
Interventions: Drug: Risdiplam; Drug: Placebo
Sponsor: Hoffmann-La Roche
Completed
Release of Nociceptin From Granulocytes in Sepsis

Conditions: Sepsis; Septic Shock; Sepsis Syndrome; Severe Sepsis
Intervention: Diagnostic Test: Septic
Sponsors: University of Leicester; The Royal College of Anaesthetists; University Hospitals, Leicester
Recruiting
Study to Assess the Safety, Pharmacokinetics and Pharmacodynamics of BOS161721 in Healthy Subjects

Condition: Healthy Participants
Interventions: Drug: BOS161721; Drug: Placebo
Sponsor: Boston Pharmaceuticals
Completed
Evaluate the Bioavailability Between 2 BMS-986141 Formulations in Healthy Participants

Condition: Healthy
Interventions: Drug: BMS-986141 Form A Tablet; Drug: BMS-986141 Form B tablet (low dose); Drug: BMS-986141 Form B tablet (high dose)
Sponsor: Bristol-Myers Squibb
Withdrawn
A Study Investigating the Excretion Balance, Pharmacokinetics and Metabolism of a Single Oral Dose of [14C]-Labeled Risdiplam (RO7034067) in Healthy Male Participants

Condition: Healthy
Intervention: Drug: [^14C]-Risdiplam
Sponsor: Hoffmann-La Roche
Completed
An Evaluation of Healthy Marriage and Relationship Education Program: Elevate

Condition: Family Relations
Intervention: Behavioral: Elevate
Sponsors: University of Georgia; Department of Health and Human Services
Withdrawn
A First in Human Study to Assess the Safety, Tolerability and Immunogenicity of a Single Dose of a Trivalent Inactivated Poliovirus Vaccine Based on Sabin Strains (sIPV) Given Intramuscularly in Healthy Adults

Condition: Healthy
Interventions: Biological: sIPV; Biological: cIPV
Sponsor: Janssen Vaccines & Prevention B.V.
Completed
Trial of a New Online Programme for Physical Activity and Healthy Eating.

Condition: Overweight/Obesity
Interventions: Behavioral: Website and pedometer intervention; Other: Control
Sponsor: University of Bath
Completed
Healthy Kids & Families: Overcoming Social, Environmental and Family Barriers to Childhood Obesity Prevention

Condition: Obesity
Interventions: Behavioral: Healthy Lifestyle; Behavioral: Positive Parenting
Sponsors: University of Massachusetts, Worcester; Oak Hill Community Development Corporation; Worcester Public Schools
Active, not recruiting
Biology of the Oral Epithelium of E-Cigarette Smokers

Condition: Healthy
Intervention:
Sponsor: Weill Medical College of Cornell University
Recruiting
Scopolamine Patch Pharmacokinetics in Healthy Adults

Condition: Healthy
Interventions: Drug: Transderm Scop®; Drug: Intravenous scopolamine hydrobromide
Sponsors: University of Iowa; University of Minnesota - Clinical and Translational Science Institute
Completed
Study of Safety and Tolerability of UNIFUZOL (Solution for Infusions) in Healthy Volunteers

Condition: Peripheral Vascular Disease
Intervention: Drug: arginine sodium succinate
Sponsor: Scientific Technological Pharmaceutical Firm Polysan, Ltd.
Completed
Healthy Life Centers - Municipal Health Care Service for Lifestyle Changes - a Multicenter Intervention Study

Conditions: Musculoskeletal Disease; Obesity; Psychological Disorder
Intervention: Behavioral: Healthy Life Center
Sponsors: Norwegian University of Science and Technology; Western Norway University of Applied Sciences
Recruiting
Within-day and Between-day Repeatability of the Breath Pattern in Healthy Children and in Children With Asthma

Conditions: Asthma; Healthy
Intervention: Other: Assessment of E-nose measurements
Sponsors: Istituto di Biomedicina e Immunologia Molecolare Alberto Monroy; Campus Bio-Medico University
Completed
A Study of LY3192767 in Healthy Participants

Condition: Healthy
Interventions: Drug: LY3192767; Drug: Basal Insulin Peglispro; Drug: Insulin Glargine; Drug: Placebo
Sponsor: Eli Lilly and Company
Terminated
Effect of Different Viscous Foods and Liquids on Swallowing Sounds

Condition: Deglutition Disorder
Intervention:
Sponsor: University of Nebraska
Completed
Pharmacokinetics and Safety of Ravidasvir and Danoprevir/r in Healthy Volunteers China

Condition: Healthy
Interventions: Drug: Ravidasvir; Drug: Danoprevir; Drug: Ritonavir; Drug: Placebo
Sponsor: Ascletis Pharmaceuticals Co., Ltd.
Completed
Safety and Tolerability of PF-06818883 in Healthy Subjects

Condition: Healthy
Interventions: Drug: Placebo; Drug: PF-06818883
Sponsor: Pfizer
Terminated
A Single Intravenous Dose Study of E3112 in Japanese Healthy Adult Male Subjects

Condition: Healthy Male Volunteers
Interventions: Drug: Placebo; Drug: E3112
Sponsor: EA Pharma Co., Ltd.
Completed
Comparative Pharmacokinetics and Food-Effect Bioavailability of Lubiprostone Sprinkle in Healthy Volunteers

Condition: Healthy Volunteers
Interventions: Drug: Lubiprostone Capsule; Drug: Lubiprostone Sprinkle Formulation
Sponsors: Sucampo AG; Sucampo Pharma Americas, LLC
Completed
A Trial Investigating the Effect of Oral Semaglutide on the Pharmacokinetics of Furosemide and Rosuvastatin in Healthy Subjects

Conditions: Diabetes; Healthy
Interventions: Drug: Furosemide; Drug: Rosuvastatin; Drug: SNAC; Drug: Semaglutide
Sponsor: Novo Nordisk A/S
Completed
Crossover Study to Evaluate the Effect of Lemborexant Versus Placebo and Zolpidem on Postural Stability, Auditory Awakening Threshold, and Cognitive Performance in Healthy Subjects 55 Years and Older

Condition: Healthy Subjects
Interventions: Drug: LEM5; Drug: LEM10; Drug: ZOL; Drug: PBO
Sponsors: Eisai Inc.; Purdue Pharma LP
Completed
A Study to Investigate Safety and Tolerability, Pharmacokinetics and Pharmacodynamics of JNJ 61393215 in Healthy Participants

Condition: Healthy
Interventions: Drug: JNJ-61393215; Drug: Placebo
Sponsor: Janssen Research & Development, LLC
Completed
Location-based Smartphone Technology to Guide College Students Healthy Choices

Conditions: Overweight and Obesity; Health Behavior; Sleep Deprivation
Interventions: Other: Healthy Detours App; Other: Fat Secret App
Sponsors: Klein Buendel, Inc.; Pennington Biomedical Research Center
Completed
First-in-Human Single and Multiple Dose of EB8018

Condition: Healthy Volunteers
Interventions: Drug: Single Ascending Doses of EB8018; Drug: Single Ascending Doses of placebo; Drug: Multiple Ascending Doses of EB8018; Drug: Multiple Ascending Doses of placebo
Sponsors: Enterome; Quotient Clinical
Completed
Bioavailability Study of SPARC001(Study 1) in Healthy Adult Volunteers

Condition: Healthy
Interventions: Drug: SPARC001 type I; Drug: SPARC001 type II; Drug: Reference001 type I; Drug: Reference001 type II
Sponsor: Sun Pharma Advanced Research Company Limited
Completed
Bioavailability Study of SPARC001 (Study 2) in Healthy Adult Volunteers

Condition: Healthy
Interventions: Drug: SPARC001 type I; Drug: SPARC001 type II; Drug: Reference001 type I; Drug: Reference001 type II
Sponsor: Sun Pharma Advanced Research Company Limited
Completed
A Study of LY3323795 in Healthy Participants

Condition: Healthy
Interventions: Drug: LY3323795; Drug: Itraconazole; Drug: Placebo
Sponsor: Eli Lilly and Company
Completed
A Phase 1 Study of KHK4083 in Healthy Volunteers and Subjects With Ulcerative Colitis

Condition: Healthy Men and Subjects With Ulcerative Colitis
Interventions: Drug: KHK4083; Drug: Placebo
Sponsor: Kyowa Hakko Kirin Co., Ltd
Completed
BI 443651 Multiple Rising Dose in Healthy Volunteers Followed by a Cross-over in CF Subjects

Condition: Cystic Fibrosis
Interventions: Drug: BI 443651; Drug: Placebo
Sponsor: Boehringer Ingelheim
Completed
Glutathione (GSH) Synthesis in Healthy School-aged Children

Condition: Healthy
Intervention: Other: varying protein intakes
Sponsor: The Hospital for Sick Children
Recruiting
Pharmacokinetics and Safety Study of Rifamycin SV-MMX® 600 mg Tablets After Single and Multiple t.i.d. Doses in Healthy Male and Female Volunteers

Condition: Healthy
Intervention: Drug: Rifamycin SV-MMX® 600
Sponsor: Cosmo Technologies Ltd
Completed
Molecular Genetic Study of Mayer-Rokitansky-Kuster-Hauser Syndrome

Condition: Mayer Rokitansky Kuster Hauser Syndrome
Interventions: Genetic: Biological samples for patients; Genetic: Biological samples for healthy relatives
Sponsors: Imagine Institute; Reference center for rare diseases (Rare Gynecologic Diseases)
Recruiting
A Study of LY2775240 in Healthy Participants

Condition: Healthy
Interventions: Drug: LY2775240; Drug: Placebo; Drug: Apremilast
Sponsor: Eli Lilly and Company
Completed
A Study of Intravenously or Subcutaneously Administered REGN3500 in Healthy Adult Subjects

Condition: Healthy Volunteers
Interventions: Drug: REGN3500; Drug: Placebo
Sponsors: Regeneron Pharmaceuticals; Sanofi
Completed
A Study in Healthy Volunteers and in Participants With Chronic Hepatitis B to Assess Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single and Multiple Doses of RO7020531

Condition: Hepatitis B, Chronic
Interventions: Other: Placebo; Drug: RO7020531
Sponsor: Hoffmann-La Roche
Recruiting
The Feasibility of TECH: Tablet Enhancement of Cognition and Health for Healthy Adults

Condition: Healthy Adults
Intervention: Other: TECH: Tablet Enhancement of Cognition and Health
Sponsor: Assuta Hospital Systems
Recruiting
A Study to Investigate the Safety, Tolerability, Pharmacokinetics and Efficacy of BC 007 in Healthy Subjects

Condition: Healthy Volunteers
Interventions: Drug: BC 007; Drug: NaCl 0.9 %
Sponsor: Berlin Cures GmbH
Completed
Volume Kinetics for Hyperoncotic Albumin in Burn Patients as Well as for Healthy Subjects

Condition: Burns
Intervention: Drug: Albumins
Sponsor: University Hospital, Linkoeping
Recruiting
Study to Investigate the Food Effect and Oral Bioavailability of Tablet Formulations Relative to Suspension Formulation of JNJ-54416076 in Healthy Participants

Condition: Healthy
Interventions: Drug: JNJ-54416076 (Oral Suspension); Drug: JNJ-54416076 (Formulation 1: Direct Compression Tablets); Drug: JNJ-54416076 (Formulation 2: Fluid Bed Granulation Tablets)
Sponsor: Janssen Research & Development, LLC
Withdrawn
Safety and Immunogenicity of Takeda's TDV in Healthy Children

Condition: Healthy Volunteers
Intervention: Biological: Tetravalent Dengue Vaccine Candidate
Sponsor: Takeda
Active, not recruiting
A MAD Study of TT301/MW189 in Healthy Volunteers

Condition: Healthy Adult Volunteers
Interventions: Drug: Cohort 1 - TT301/MW189; Drug: Cohort 2- TT301MW189; Drug: Cohort 3 - TT301/MW189; Other: Cohort 1 Placebo; Other: Cohort 2 Placebo; Other: Cohort 3 Placebo
Sponsors: Linda Van Eldik; Duke Clinical Research Institute; Alzheimer's Association
Recruiting
Evaluate the Safety, Tolerability and PK of Different Formulations of Orally Administered Solabegron in Healthy Male Subjects

Condition: Healthy Subjects, Overactive Bladder
Interventions: Drug: Formulation 1 solabegron; Drug: Formulation 2 solabegron
Sponsor: Velicept Therapeutics, Inc.
Enrolling by invitation
Study for MR Formulation of PF-06650833 in Healthy Adult Japanese Subjects

Condition: Healthy
Interventions: Drug: PF-06650833; Drug: placebo
Sponsor: Pfizer
Completed
The Response To Ajmaline Provocation in Healthy Subjects

Conditions: Brugada Syndrome; Sudden Death
Intervention: Drug: Ajmaline
Sponsor: St George's, University of London
Recruiting
A Study of SHR-1314 in Healthy Subjects

Condition: Psoriasis
Interventions: Drug: SHR-1314; Drug: placebo
Sponsor: Atridia Pty Ltd.
Completed
A Study of Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of CC-90006 in Healthy Subjects

Condition: Healthy Volunteers
Interventions: Drug: Placebo; Drug: CC-90006
Sponsor: Celgene
Completed
Safety of Intranasal Irrigation Probiotics in Healthy Volunteers

Condition: Sinusitis
Intervention: Other: Probiotics
Sponsor: Probionase Therapies Inc.
Recruiting
A Study to Investigate Safety, Tolerability, and Pharmacokinetics of JNJ-56136379 in Healthy Japanese Adult Participants

Condition: Healthy
Interventions: Drug: JNJ-56136379; Other: Placebo
Sponsor: Janssen Research & Development, LLC
Completed
Placebo-Controlled Single Dose Study to Evaluate Safety and Pharmacokinetics of GMI-1359 in Healthy Volunteers

Condition: Healthy
Interventions: Drug: GMI-1359; Drug: Placebo
Sponsors: GlycoMimetics Incorporated; Celerion
Active, not recruiting
Postprandial Effects of Mixed Herbs and Spices on Pathways Associated With Glucose Homeostasis and Inflammation on PBMCs of Healthy Subjects

Condition: Healthy
Interventions: Other: High fat challenge breakfast; Other: High fat challenge breakfast with mixed-spices
Sponsors: Lund University; Anti-Diabetic Food Centre
Completed
Effect of Vortioxetine, Paroxetine, and Placebo on Sexual Functioning in Healthy Volunteers

Condition: Healthy Volunteers
Interventions: Drug: Vortioxetine; Drug: Paroxetine; Drug: Placebo
Sponsor: Takeda
Completed
Ascending Doses of Autologous FDP vs FFP

Condition: Freeze Dried Plasma in Healthy Volunteers
Interventions: Biological: Autologous Freeze Dried Plasma (FDP); Biological: Fresh Frozen Plasma (FFP)
Sponsor: U.S. Army Medical Research and Materiel Command
Recruiting
Speed of Processing Training in Patients With Parkinson's Disease and Healthy Older Adults

Condition: Parkinson's Disease
Intervention: Behavioral: Speed of processing training (SOPT)
Sponsors: University of Alabama at Birmingham; National Institute on Aging (NIA)
Completed
A Study to Assess the Effect of Particle Size of AZD7594 on Pharmacokinetics (PK) After a Single Inhaled Dose When Administered Using the Dry Powder Inhaler in Healthy Volunteers

Condition: Asthma, Chronic Obstructive Pulmonary Disease (COPD)
Interventions: Drug: Treatment A - AZD7594; Drug: Treatment B - AZD7594; Drug: Treatment C - AZD7594
Sponsor: AstraZeneca
Completed
Injectable DMAU for Male Contraception in Healthy Male Volunteers (CCN015)

Conditions: Healthy Men; Male Contraception
Interventions: Drug: Dimethandrolone Undecanoate; Drug: Placebo
Sponsors: Health Decisions; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD); Los Angeles Biomedical Research Institute; University of Washington
Recruiting
Assessment of Pharmacokinetics (PK) and Safety of M834 and Orencia ®, in Healthy Subjects

Condition: Healthy Volunteers
Interventions: Biological: M834; Biological: US-Sourced Orencia®; Biological: EU-Sourced Orencia®
Sponsors: Momenta Pharmaceuticals, Inc.; Mylan Inc.
Completed
A Trial Investigating the Influence of Oral Semaglutide on the Pharmacokinetics of Levothyroxine and the Influence of Co-administered Tablets on the Pharmacokinetics of Semaglutide Administered Orally in Healthy Subjects.

Conditions: Diabetes; Healthy
Interventions: Drug: Semaglutide; Drug: SNAC; Drug: Levothyroxine; Drug: Placebo
Sponsor: Novo Nordisk A/S
Completed
A Single Ascending Dose Study of ACT-541468 in Healthy Male Subjects

Condition: Healthy Subjects
Interventions: Drug: ACT-541468 (Formulation A); Drug: ACT-541468 (Formulation B); Drug: Placebo (Formulation A); Drug: Placebo (Formulation B); Drug: 14C-labeled ACT-541468; Drug: Placebo tracer
Sponsor: Idorsia Pharmaceuticals Ltd.
Completed
A Study to Evaluate Cenerimod in Healthy Male Subjects

Condition: Healthy Subjects
Intervention: Drug: Cenerimod
Sponsor: Idorsia Pharmaceuticals Ltd.
Completed
Comparative Clinical Trial to Evaluate Bioequivalency and Safety of Monoclonal Antibody Injection and Adalimumab in Chinese Healthy Volunteers

Condition: Healthy
Interventions: Drug: human recombinant anti-tumor necrosis factor alpha monoclonal antibody injection; Drug: adalimumab
Sponsor: Innovent Biologics (Suzhou) Co. Ltd.
Completed
A Thorough QTc Trial Evaluating the Effect of SNAC on Cardiac Repolarisation in Healthy Male Subjects.

Condition: Healthy
Interventions: Drug: SNAC; Drug: Placebo; Drug: Moxifloxacin
Sponsor: Novo Nordisk A/S
Completed
Validation of a Medical Device, a Mobile Spectrofluorimeter, Measuring Skin Autofluorescence in Healthy Volunteers.

Condition: Healthy Volunteers
Intervention: Device: mobile spectrofluorimeter
Sponsor: Institut de Cancérologie de Lorraine
Completed
A Study to Determine the Bioavailability and Food Effect of a Single TAK-935 Dose in Healthy Participants

Condition: Healthy Volunteers
Interventions: Drug: TAK-935 Tablets; Drug: TAK-935 Oral Solution
Sponsor: Takeda
Completed
A Study to Evaluate if AC-084 is Safe, Its Fate in the Body as Well as Its Potential Effects on the Body in Healthy Subjects

Condition: Healthy Subjects
Interventions: Drug: AC-084; Drug: Placebo
Sponsor: Idorsia Pharmaceuticals Ltd.
Terminated
"The Healthy Body Image" (HBI) Program: A Program to Promote a Positive Body Image

Conditions: Quality of Life; Eating Behaviors; Physical Activity
Intervention: Other: The "Healthy Body Image" intervention
Sponsors: Norwegian School of Sport Sciences; The Norwegian Women´s Public Health Association; Norwegian Extra Foundation for Health and Rehabilitation; University of Tromso; University College of Southeast Norway; University of Agder
Completed
A Study in Healthy Volunteers and Patients With Chronic Hepatitis B

Condition: Chronic Hepatitis B
Interventions: Drug: ABI-H0731; Drug: Placebo for ABI-H0731; Drug: Entecavir; Drug: Tenofovir disoproxil fumarate; Drug: Pegasys; Drug: Nucleos(t)ide
Sponsor: Assembly Biosciences
Completed
A Single Dose Study of E6130 in Japanese Healthy Adult Male Subjects

Condition: Japanese Healthy Adult Male Participants
Interventions: Drug: E6130; Drug: Placebo
Sponsor: EA Pharma Co., Ltd.
Completed
Magnetic Resonance Imaging (MRI) Sequences Optimization in Healthy Subjects

Condition: Healthy Volunteers
Intervention: Device: Magnetic Resonance Imaging
Sponsor: Rennes University Hospital
Recruiting
Neurophysiological Correlates of Cognitive Tasks in Healthy Volunteers -WP3 P003

Conditions: Alzheimer Disease; ELECTROENCEPHALOGRAPHIC VARIANT PATTERN 1 (Disorder)
Intervention: Other: Rapid Visual Information Processing (RVIP) test
Sponsor: University Hospital, Lille
Recruiting
Effect of Hypoxia on Cognitive Assessment and Cerebral Activity in Healthy Volunteers

Conditions: Alteration of Cognitive Function; Hypoxia
Intervention: Other: 2-hour period of hypoxia
Sponsor: University Hospital, Lille
Recruiting
Single Rising Dose Study of BI 690517 in Healthy Volunteers

Condition: Healthy
Intervention: Drug: BI 690517
Sponsor: Boehringer Ingelheim
Completed
IV Dosage Form of LCB01-0371 Phase I Study in Healthy Male Volunteers

Condition: Healthy
Interventions: Drug: LCB01-0371; Drug: LCB01-0371 400mg
Sponsor: LegoChem Biosciences, Inc
Completed
A Study to Assess the Impact of Speed and Site of Subcutaneous Injection on Pain, Tolerability, Safety, and Pharmacokinetics of Gantenerumab in Healthy Participants

Condition: Healthy Volunteer
Interventions: Drug: Gantenerumab; Drug: Placebo
Sponsor: Hoffmann-La Roche
Completed
A First-In-Human Study With a Single Ascending Dose of UCB7858 in Healthy Volunteers

Condition: Healthy Volunteers
Interventions: Drug: UCB7858; Drug: Placebo
Sponsor: UCB Biopharma S.P.R.L.
Completed
A Study to Compare the Oral Bioavailability of Single Doses of Three Vapendavir Drug Formulations in Healthy Volunteers

Condition: Healthy
Interventions: Drug: vapendavir 132 mg capsule; Drug: vapendavir 264 mg tablet; Drug: vapendavir 24 mg/mL oral suspension
Sponsor: Vaxart
Completed
A Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of E2027 in Healthy Subjects

Condition: Healthy Subjects
Interventions: Drug: E2027; Drug: E2027 matched placebo
Sponsor: Eisai Inc.
Completed
Single Dose, Repeated Dose, and Conditional Food Effect Study of PF-05221304 in Healthy Subjects

Condition: Normal Healthy
Interventions: Drug: PF-05221304; Other: Placebo
Sponsor: Pfizer
Completed
Clinical Trial of GX-I7 in Healthy Volunteers

Condition: Healthy
Interventions: Drug: GX-I7; Drug: Placebo
Sponsor: Genexine, Inc.
Active, not recruiting
A Study to Evaluate Safety, Tolerability, and Immunogenicity of Heterologous Prime-boost Regimens Using the Multivalent Filovirus Vaccines Ad26.Filo and MVA-BN-Filo Administered in Different Sequences and Schedules in Healthy Adults

Condition: Healthy
Interventions: Biological: Ad26.Filo; Biological: MVA-BN-Filo; Biological: Ad26.ZEBOV; Biological: Placebo
Sponsors: Janssen Vaccines & Prevention B.V.; National Institute of Allergy and Infectious Diseases (NIAID)
Completed
A Dose-Escalation Study to Evaluate Safety, Tolerability and Pharmacokinetics of Multiple Doses of Q203 in Normal Healthy Male and Female Volunteers

Condition: Healthy Volunteers
Interventions: Drug: Q203; Drug: Placebo
Sponsor: Qurient Co., Ltd.
Completed
Safety, Tolerability, Pharmacokinetic and Absolute Bioavailability Study of JNJ-63623872 Administered as an Intravenous Infusion and a 600-Milligram (mg) Oral Dose in Healthy Adults

Condition: Healthy
Interventions: Drug: JNJ-63623872; Drug: Placebo
Sponsor: Janssen-Cilag International NV
Completed
A Study to Assess the Relative Bioavailability And Food Effect of a Tablet Formulation of GDC-0276 in Healthy Participants

Condition: Healthy Volunteer
Interventions: Drug: GDC-0276 capsule; Drug: GDC-0276 tablets
Sponsor: Genentech, Inc.
Withdrawn
Cortical Plasticity After Motor Cortex Stimulation in Healthy Subject and Chronic Pain Patients

Condition: Neuropathic Pain
Intervention: Device: Repetitive Transcranial Magnetic Stimulation (rTMS)
Sponsor: Hospices Civils de Lyon
Completed
A Study of Pressure and Flow Characteristics During Inspiration and Expiration Using BreatheMAX® in Healthy Subjects

Condition: Healthy Subjects
Intervention: Device: BreatheMAX breathing device
Sponsor: Khon Kaen University
Completed
Study to Assess the Safety, Tolerability, PK, ECG Effects, Food Effect, and Drug-drug Interaction (DDI) of Hormonal Contraceptives of PTI-428 in Healthy Female Volunteers

Condition: Healthy Volunteer
Interventions: Drug: PTI-428; Other: Placebo; Drug: ethinyl estradiol and levonorgestrel
Sponsor: Proteostasis Therapeutics, Inc.
Completed
Study of AC0058TA in Healthy Male and Female Subjects

Condition: Healthy Volunteers
Interventions: Drug: AC0058TA; Drug: Placebo capsules
Sponsor: ACEA Biosciences, Inc.
Completed
A Study to Investigate the Effect of ACT-132577 on the Pharmacokinetics of Midazolam and 1-hydroxy Midazolam in Healthy Male Subjects

Condition: Healthy Subjects
Interventions: Drug: Midalozam; Drug: ACT-132577
Sponsor: Idorsia Pharmaceuticals Ltd.
Completed
A Study to Assess the Effects of Age and Gender on the Pharmacokinetics of JNJ-42847922 in Healthy Adults

Condition: Healthy
Interventions: Drug: JNJ-42847922 10 milligram (mg); Drug: JNJ-42847922 20 mg; Drug: JNJ-42847922 40 mg; Drug: JNJ-42847922 60 or 80 mg
Sponsor: Janssen Research & Development, LLC
Completed
A Study of Galcanezumab in Healthy Participants.

Condition: Healthy
Intervention: Biological: Galcanezumab
Sponsor: Eli Lilly and Company
Completed
The Effects of Single-Pulse Transcranial Magnetic Stimulation on the Autonomic Nervous System in Healthy Adults

Condition: Healthy
Intervention: Device: Single-Pulse Transcranial Magnetic Stimulation
Sponsor: University of Minnesota - Clinical and Translational Science Institute
Recruiting
Neural Correlates of Intern Speech

Condition: Healthy Volunteer
Interventions: Other: Healthy volunteers; Device: MRI
Sponsor: University Hospital, Grenoble
Terminated
Abnormal Fecal Microbiota in Healthy Subjects at High Risk for Crohn's Disease

Conditions: Crohn's Disease; Genetic Predisposition
Intervention: Other: biomarkers
Sponsor: University Hospital, Lille
Recruiting
Collection of Peripheral Blood Mononuclear Cells (PBMCs) From Healthy People for the Expansion of T Cells for Adoptive Cell Therapy

Condition: Healthy Volunteer
Intervention:
Sponsor: National Cancer Institute (NCI)
Recruiting
Study to Investigate the Pharmacokinetics, Safety and Tolerability of Odalasvir and AL-335 in Healthy Japanese Participants

Condition: Healthy
Interventions: Drug: Odalasvir (ODV); Drug: AL-335; Drug: Placebo
Sponsor: Janssen Research & Development, LLC
Completed
A Bioavailability Crossover Study of Two Formulations of Lamotrigine Extended Release Tablets in Healthy Subjects

Condition: Healthy
Intervention: Drug: Lamotrigine Extended Release
Sponsors: Food and Drug Administration (FDA); Vince & Associates Clinical Research, Inc.; Algorithme Pharma Inc
Completed
Pharmacokinetics Study of Zolpidem Hemitartarate Orodispersible Tablet 1.75 mg Formulation

Condition: Healthy
Interventions: Drug: zolpidem hemitartarate 1.75 mg - Sequency 1; Drug: zolpidem hemitartarate 1.75 mg - Sequency 2
Sponsor: Biolab Sanus Farmaceutica
Completed
Bioavailability and Mucosal Bioactivity of Avmacol® in Healthy Volunteers

Condition: Healthy
Intervention: Dietary Supplement: Avmacol
Sponsor: University of Pittsburgh
Completed
Study to Evaluate Safety, Tolerability, and Pharmacokinetics of Minocin® (Minocycline) for Injection in Healthy Adults

Condition: Normal Healthy Volunteers
Interventions: Drug: Minocin (minocycline) for Injection; Other: Placebo
Sponsors: Rempex (a wholly owned subsidiary of Melinta Therapeutics, Inc.); Universitätsklinikum Köln; Innovative Medicines Initiative
Completed
Clinical Trial In Healthy Volunteers And Health Elderly Volunteers To Evaluate The Safety, Tolerability And Blood Concentration After Single And Multiple Escalating Oral Doses Of PF-06751979.

Condition: Healthy Subjects
Interventions: Drug: PF-06751979 single dose; Drug: Placebo single dose; Drug: PF-06751979 multiple ascending dose; Drug: Placebo multiple ascending dose; Drug: PF-06751979 multiple dose; Drug: Placebo multiple elderly dose
Sponsor: Pfizer
Completed
Adjustment Exploratory Protocols and Functional Evaluation of New Non Invasive Devices in Healthy Volunteers

Condition: Healthy Volunteers
Interventions: Device: Imaging devices; Device: New Non Invasive Devices
Sponsor: University Hospital, Grenoble
Recruiting
A Randomized, Double Blind Placebo-Controlled, Single Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of BMS-986166 in Healthy Subjects

Condition: Healthy
Interventions: Drug: BMS-986166; Drug: Placebo matching BMS-986166
Sponsor: Bristol-Myers Squibb
Completed
The Influence of Aircraft Noise Exposure on Renal Hemodynamic in Healthy Individuals

Conditions: Healthy Individuals; Arterial Hypertension
Interventions: Procedure: Noise; Procedure: Silence
Sponsor: University of Erlangen-Nürnberg Medical School
Completed
Study of Safety, Tolerability, and Pharmacokinetics of REGN3470-3471-3479 in Healthy Adult Volunteers

Condition: Healthy Volunteers
Interventions: Drug: REGN3470-3471-3479; Drug: Placebo
Sponsors: Regeneron Pharmaceuticals; Department of Health and Human Services
Completed
Influence of a Modified Ramadan Fasting on Health and Well-being in Healthy Muslims - a Randomised Controlled Trial

Condition: Healthy Volunteers
Intervention: Behavioral: Modified Ramadan Fasting
Sponsor: Universität Duisburg-Essen
Completed
Impact of Once-Weekly Rifapentine and Isoniazid on the Steady State Pharmacokinetics of Dolutegravir and Darunavir Boosted With Cobicistat in Healthy Volunteers

Condition: Healthy Volunteers
Interventions: Drug: rifapentene (RPT); Drug: darunavir/cobicistat (DRV/c); Drug: Isoniazid (INH)
Sponsor: National Institutes of Health Clinical Center (CC)
Recruiting
A Phase 1 Pharmacokinetic Study of Single-Ascending Doses of Intravenous Nafithromycin in Healthy Adult Subjects

Condition: Healthy Volunteers
Interventions: Drug: Nafithromycin; Drug: Placebo
Sponsor: Wockhardt
Completed
Study of TAK-071 in Healthy Participants and Participants With Mild Cognitive Impairment/Mild Alzheimer Disease and Relative Bioavailability (BA) and Food Effect of TAK-071 in Healthy Participants

Conditions: Alzheimer Disease; Healthy Volunteers
Interventions: Drug: TAK-071; Drug: Donepezil; Drug: TAK-071 Placebo; Drug: Donepezil Placebo
Sponsor: Takeda
Terminated
Evaluation Of Safety, Tolerability And Pharmacokinetics Of Single And Multiple Doses Of Compound PF-06823859

Condition: Healthy
Interventions: Biological: PF-06823859; Drug: Placebo injection SC/IV
Sponsor: Pfizer
Completed
Healthy Aging Practice-centered Instruction Cardiovascular Health Investigation (HAPI-CHI)

Conditions: Hypertension; Prehypertension
Interventions: Behavioral: Healthy Aging Practice-centered Instruction (HAPI); Behavioral: Tai Chi (CHI)
Sponsor: University of California, San Diego
Enrolling by invitation
A Study of Baricitinib (LY3009104) in Healthy Chinese Participants

Condition: Healthy
Interventions: Drug: Baricitinib; Drug: Placebo
Sponsor: Eli Lilly and Company
Completed
Bioequivalence of a Fixed Dose Combination Tablet of Empagliflozin/Linagliptin Compared With the Free Combination of Empagliflozin Tablet and Linagliptin Tablet in Healthy Male and Female Subjects

Condition: Healthy
Interventions: Drug: Empagliflozin; Drug: Linagliptin
Sponsors: Boehringer Ingelheim; Eli Lilly and Company
Completed
A Phase I SAD and MAD Clinical Trial of CNM-Au8 in Healthy Male and Female Volunteers

Condition: Healthy Volunteers - Male and Female
Interventions: Other: CNM-Au8; Other: Placebo
Sponsor: Clene Nanomedicine
Completed
Supporting Healthy Aging by Peer Education and Support

Conditions: Health Behavior; Ageing
Intervention: Behavioral: Peer-led Health Education
Sponsors: University of Alberta; Covenant Health
Recruiting
Efficacy, Safety and Immunogenicity of Takeda's Tetravalent Dengue Vaccine (TDV) in Healthy Children

Condition: Healthy Volunteers
Interventions: Biological: Takeda's Tetravalent Dengue Vaccine Candidate; Drug: TDV Placebo
Sponsor: Takeda
Active, not recruiting
A Study to Determine the Safety, Tolerability, and Pharmacokinetics of GDC-0310 in Healthy Volunteers

Condition: Healthy Volunteer
Interventions: Drug: GDC-0310; Drug: Placebo
Sponsor: Genentech, Inc.
Completed
A Study to Evaluate the Effects of Esketamine on Cardiac Repolarization in Healthy Participants

Condition: Healthy
Interventions: Drug: Intranasal Esketamine; Drug: Intravenous Esketamine; Drug: Moxifloxacin; Drug: Oral Placebo; Drug: Intravenous Placebo; Drug: Intranasal Placebo
Sponsor: Janssen Research & Development, LLC
Completed
Effects of Sleep Deprivation on Diaphragm Command During an Inspiratory Endurance Trial in Healthy Volunteers.

Conditions: Sleep Deprivation; Healthy Volunteers; Diaphragm
Interventions: Behavioral: Sleepless night; Behavioral: Normal sleep night
Sponsor: Poitiers University Hospital
Completed
TAK-020 Relative Bioavailability and Food Effect Study in Healthy Participants

Condition: Healthy
Interventions: Drug: TAK-020 Captisol Oral Solution; Drug: TAK-020 CCT; Drug: TAK-020 SDT; Drug: TAK-020 IRT; Drug: TAK-020 Solid Formulation
Sponsor: Takeda
Completed
Use of 31P MRS to Assess Brain NAD+ in Healthy Collegiate Athletes

Condition: Concussion, Mild
Interventions: Dietary Supplement: Nicotinamide Riboside; Other: Matching placebo
Sponsors: Mayo Clinic; University of Minnesota - Clinical and Translational Science Institute; Thorne Research Inc.
Recruiting
Safety, Tolerability, and Pharmacokinetics of a Single Oral Dose of SKI-O-703 in Healthy Volunteers

Condition: Rheumatoid Arthritis
Interventions: Drug: SKI-O-703 capsule; Drug: Placebo capsule
Sponsors: Oscotec Inc.; PPD
Completed
Promoting Healthy Eating and Active Playtime by Connecting Preschool Children to Nature

Conditions: Sedentary Lifestyle; Overweight; Eating Disorders
Interventions: Other: Healthy lifestyle; Other: physical activity and dietary guidelines
Sponsor: The University of Hong Kong
Recruiting
A Single-Dose Study to Investigate the Safety, Tolerability, and Pharmacokinetics (PK) of Gantenerumab Following Subcutaneous (SC) Administration in Healthy Volunteers

Condition: Healthy Volunteer
Interventions: Drug: Gantenerumab; Drug: Placebo
Sponsor: Hoffmann-La Roche
Completed
Bioavailability Study of Five Tablet Formulations of Dabigatran Etexilate Compared to Commercial Capsule Formulation in Healthy Male Subjects

Condition: Healthy
Interventions: Drug: Dabigatran etexilate tablet E1; Drug: Dabigatran etexilate tablet D1; Drug: Dabigatran etexilate tablet C1; Drug: Dabigatran etexilate tablet B1; Drug: Dabigatran etexilate tablet A1; Drug: Dabigatran etexilate capsule
Sponsor: Boehringer Ingelheim
Completed
Clinical Study to Assess Body Fluid Homeostasis After Administration of ACT-132577 in Healthy Subjects

Condition: Healthy Subjects
Interventions: Drug: ACT-132577; Other: Placebo
Sponsor: Idorsia Pharmaceuticals Ltd.
Completed
SET-Recovery/Healthy Home

Conditions: Substance-Related Disorders; Mental Health
Intervention: Behavioral: SET-R/Healthy Home
Sponsor: University of Miami
Completed
Environmental Influences on Early Childhood Obesity

Condition: Childhood Obesity
Interventions: Behavioral: Healthy Homes; Other: Usual Care
Sponsor: University of Colorado, Denver
Active, not recruiting
TOP-mums, for a Healthy Start

Conditions: Overweight; Obesity; Pregnancy Complications
Intervention: Behavioral: Lifestyle intervention
Sponsor: Maastricht University Medical Center
Recruiting
First-in-man Study of Single and Multiple Ascending Doses of a New Drug for Neurological Disorders

Condition: Healthy Subjects
Interventions: Drug: AC-082; Drug: Placebo
Sponsor: Idorsia Pharmaceuticals Ltd.
Completed
A Study to Evaluate the PK, Safety and Tolerability of GMI-1271 With and Without Filgrastim in Healthy Adult Subjects

Condition: Healthy Volunteers
Interventions: Drug: GMI-1271; Drug: Filgrastim; Drug: Placebo Injection; Drug: Placebo Infusion
Sponsors: GlycoMimetics Incorporated; Celerion
Completed
The Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of RO6889450 in Healthy Volunteers

Condition: Healthy Volunteer
Interventions: Drug: Placebo; Drug: RO6889450
Sponsor: Hoffmann-La Roche
Completed
Effect of Food, Rabeprazole, Methotrexate and Formulation on the Pharmacokinetics (PK) of GDC-0853 and the Effect of GDC-0853 on the PK of Methotrexate in Healthy Subjects

Condition: Healthy Volunteer
Interventions: Drug: Folic Acid; Drug: GDC-0853; Drug: Methotrexate; Drug: Rabeprazole
Sponsor: Genentech, Inc.
Completed
Healthy Caregivers-Healthy Children (HC2) Phase II

Conditions: Pediatric Obesity; Obesity
Interventions: Behavioral: Healthy Caregivers- Healthy Children Toolkit; Behavioral: Safety Curriculum
Sponsor: University of Miami
Recruiting
Single Rising Dose Study of BI 655088 Administered Intravenously in Healthy Male Volunteers

Condition: Healthy
Interventions: Drug: BI 655088; Drug: Placebo
Sponsor: Boehringer Ingelheim
Recruiting
A Study to Assess the Absorption, Metabolism, and Routes of Excretion Following Oral Administration of (14C) Radiolabeled JNJ--42756493 to Healthy Male Participants

Condition: Healthy
Intervention: Drug: JNJ-42756493
Sponsor: Janssen Research & Development, LLC
Completed
Multiple Dose Study Of PF-05251749 In Healthy Volunteers

Conditions: Healthy Adult Subjects; Healthy Elderly Subjects
Interventions: Drug: PF-05251749; Drug: Melatonin
Sponsor: Pfizer
Completed
A Pilot Study of Rapid Haplotyping Procedure for Personalized Dosing of Dichloroacetate (DCA) in Healthy Volunteers

Condition: Healthy
Interventions: Drug: Dichloroacetate (DCA); Other: GSTZ1 haplotyping
Sponsors: University of Florida; Medosome Biotec LLC; Food and Drug Administration (FDA)
Completed
To Evaluate the Food Effect on Relative Bioavailability of RP6530 in Healthy Volunteers

Condition: Healthy
Intervention: Drug: RP6530
Sponsor: Rhizen Pharmaceuticals SA
Completed
Safety, Tolerability and Immunogenicity Study of Different Vaccine Schedules With Ad26.Mos.HIV and Clade C Glycoprotein (gp)140 in Healthy Human Immunodeficiency Virus (HIV)-Uninfected Adults

Condition: Healthy
Interventions: Biological: Ad26.Mos.HIV; Biological: Clade C gp140; Drug: Placebo
Sponsor: Janssen Vaccines & Prevention B.V.
Completed
Study to Evaluate the Safety, Biodistribution, Radiation Dosimetry and Tumor Imaging Potential of [131I]-SGMIB Anti-HER2 VHH1 in Healthy Volunteers and Breast Cancer Patients

Conditions: Healthy Volunteers; Breast Cancer
Intervention: Biological: [131I]-SGMIB Anti-HER2 VHH1
Sponsor: Camel-IDS NV
Completed
Lofexidine Pharmacokinetics in the Presence of Paroxetine in Healthy Volunteers

Condition: Healthy
Interventions: Drug: Lofexidine; Drug: Paroxetine
Sponsors: US WorldMeds LLC; National Institute on Drug Abuse (NIDA)
Completed
A Study of Abemaciclib in Healthy Participants

Condition: Healthy
Interventions: Drug: Abemaciclib; Drug: Placebo; Drug: Loperamide
Sponsor: Eli Lilly and Company
Completed
A Study of Abemaciclib in Healthy Participants

Condition: Healthy
Interventions: Drug: Abemaciclib Capsules (Reference Formulation); Drug: Abemaciclib Tablet (Test Formulation)
Sponsor: Eli Lilly and Company
Completed
A Study to Investigate the Safety, Tolerability, Food Effect, and Pharmacokinetics of JNJ-54416076 in Healthy Participants

Condition: Healthy
Interventions: Drug: JNJ-54416076; Drug: Placebo
Sponsor: Janssen Research & Development, LLC
Completed
Phase I, Open Label Dose Ranging Safety Study of GLS-5300 in Healthy Volunteers

Condition: Healthy
Intervention: Biological: GLS-5300
Sponsors: GeneOne Life Science, Inc.; Inovio Pharmaceuticals; Walter Reed Army Institute of Research (WRAIR)
Completed
Safety and Pharmacokinetics Study of Multiple Ascending Doses of BTA-C585 in Healthy Volunteers

Conditions: Pharmacokinetics; Healthy Volunteers
Interventions: Drug: BTA-C585 oral capsules; Drug: BTA-C585 matching placebo
Sponsor: Biota Pharmaceuticals, Inc.
Completed
A Study of the Safety, Tolerability, and Pharmacokinetics of Single and Multiple Doses of RTA 901 in Healthy Adults

Condition: Healthy
Interventions: Drug: RTA 901 Capsules, 10 or 40 mg; Drug: Placebo
Sponsor: Reata Pharmaceuticals, Inc.
Completed
A Study of Orally Administered JNJ-56136379 to Evaluate Safety, Tolerability and Pharmacokinetics After Single Ascending Doses and One Multiple Dose Regimen in Healthy Participants (Part I), and After Multiple Dose Regimens in Participants With Chronic Hepatitis B (Part II)

Conditions: Healthy; Hepatitis, Chronic
Interventions: Drug: JNJ-56136379; Drug: Placebo
Sponsor: Janssen Sciences Ireland UC
Completed
Impact of Aging on Cytokine Production by Innate Immune Cells

Condition: Healthy
Intervention: Other: Healthy Volunteers
Sponsor: Centre Hospitalier Universitaire de Nice
Completed
Safety, Tolerability and Pharmacokinetics of KBP-5074 in Healthy Subjects and Subjects With Renal Impairment

Conditions: Healthy; Renal Insufficiency
Intervention: Drug: KBP-5074
Sponsor: KBP Biosciences
Completed
A Phase I Study to Assess PK of AZD7986 Alone & With Verapamil, Itraconazole or Diltiazem in Healthy Subjects

Condition: Healthy Subjects
Interventions: Drug: AZD7986; Drug: Verapamil; Drug: Itraconazole; Drug: Diltiazem
Sponsor: AstraZeneca
Completed
Growth and Metabolic Biomarkers of Healthy Term Infants Fed Formulas With Staged Protein Concentrations Over the First Year of Life

Condition: Healthy Term Infants
Interventions: Dietary Supplement: Formula regimen 1; Dietary Supplement: Formula regimen 2
Sponsor: Nestlé
Recruiting
Screening of Healthy Volunteers for Investigational Antimalarial Drugs, Malaria Vaccines, and Controlled Human Malaria Challenge

Condition: Malaria
Intervention:
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting
HP Xenon-129 fMRI of Healthy Volunteers and Participants With Alzheimer's Disease

Condition: Alzheimer Disease
Interventions: Other: Traditional Proton fMRI; Other: Hyperpolarized Xenon-129 fMRI; Drug: Hyperpolarized Xenon-129; Device: 1H-129Xe Dual-Tuned Quadrature Head Coil
Sponsors: Thunder Bay Regional Research Institute; Lakehead University; Thunder Bay Regional Health Sciences Centre
Recruiting
A Study to Assess The Effects Of Effexor XR On Cardiac Repolarization In Healthy Adult Subjects

Condition: Healthy Subjects
Interventions: Drug: Venlafaxine; Drug: Moxifloxacin; Drug: Drug - placebo
Sponsor: Pfizer
Completed
Bioequivalence Study of Fentanyl Transdermal System (JNJ-35685-AAA-G021) Compared With DURAGESIC Fentanyl Transdermal Patch in Healthy Participants

Condition: Healthy
Intervention: Drug: Fentanyl
Sponsor: Janssen Research & Development, LLC
Completed
Single Ascending Dose Study of AMG 570 in Healthy Subjects

Condition: Systemic Lupus Erythematosus
Interventions: Biological: AMG 570; Biological: AMG 570 Matching Placebo
Sponsor: Amgen
Completed
A Single Ascending Dose Study in Healthy Participants and Multiple Dose Study of JNJ-55920839 in Participants With Mild to Moderate Systemic Lupus Erythematosus

Conditions: Systemic Lupus Erythematosus; Healthy
Interventions: Drug: JNJ-55920839; Drug: Placebo
Sponsor: Janssen Research & Development, LLC
Completed
Be Healthy, So Easy: FAMILY Education Project

Condition: Hypokinesia
Interventions: Behavioral: Zero-time Exercise; Behavioral: Healthy Eating
Sponsors: The University of Hong Kong; Caritas Medical Centre, Hong Kong; The Hong Kong Jockey Club Charities Trust
Completed
A Study to Investigate Safety, Tolerability, and Pharmacokinetics of DSTA4637S in Healthy Volunteers

Condition: Healthy Volunteer
Interventions: Drug: DSTA4637S; Drug: Placebo
Sponsor: Genentech, Inc.
Completed
Study to Evaluate the Effect of Lemborexant Versus Placebo on Driving Performance in Healthy Adult and Elderly Subjects

Condition: Healthy Participants
Interventions: Drug: Placebo tablet matching lemborexant; Drug: Placebo tablet matching zopiclone; Drug: Zopiclone 7.5 mg; Drug: Lemborexant 2.5 mg; Drug: Lemborexant 5 mg; Drug: Lemborexant 10 mg
Sponsors: Eisai Inc.; Purdue Pharma LP
Completed
Influence of Light Exposure on Cerebral MAO-A in Seasonal Affective Disorder and Healthy Controls Measured by PET

Condition: Seasonal Affective Disorder
Interventions: Other: Light Therapy; Other: Placebo Light
Sponsor: Medical University of Vienna
Completed
Gender Differences in Social Cognition in Patients With Schizophrenia of Recent Diagnosis and Healthy Controls Subjects

Conditions: Women With Recent Diagnosis of Schizophrenia; Men With Recent Diagnosis of Schizophrenia; Healthy Women; Healthy Men
Intervention: Other: GENDER
Sponsor: Corporacion Parc Tauli
Completed
A Study of LY2951742 in Healthy Participants

Condition: Healthy
Interventions: Drug: LY2951742; Drug: Placebo
Sponsor: Eli Lilly and Company
Completed
A Study to Investigate the Safety, Tolerability, Pharmacokinetics (PK), and Pharmacodynamics (PD) of ACT-541468 in Healthy Young Adults and Elderly Subjects

Condition: Healthy Subjects
Interventions: Drug: ACT-541468 (hydrochloride salt); Drug: ACT-541468 (free base); Drug: Placebo
Sponsor: Idorsia Pharmaceuticals Ltd.
Completed
A Study of Mirikizumab (LY3074828) in Healthy Participants

Condition: Healthy
Interventions: Drug: Mirikizumab - IV; Drug: Mirikizumab - SC; Drug: Placebo - IV; Drug: Placebo - SC
Sponsor: Eli Lilly and Company
Completed
Methionine Tolerance in Healthy Human Adults

Condition: Healthy
Intervention: Dietary Supplement: methionine
Sponsors: Texas A&M University; International Council on Amino Acid Science
Completed
Phase 1 Safety and Pharmacokinetics Study of Single Ascending Doses of BTA-C585 in Healthy Volunteers

Conditions: Pharmacokinetics; Healthy Volunteers
Interventions: Drug: BTA-C585 oral capsules; Drug: BTA-C585 matching placebo
Sponsor: Biota Pharmaceuticals, Inc.
Completed
Cerebellar tDCS on Motor Learning of Healthy Individuals

Condition: Healthy
Intervention: Device: tDCS
Sponsor: Universidade Federal de Pernambuco
Completed
Pharmacodynamic Study of Cilostazol in Healthy Volunteers

Condition: Healthy
Interventions: Drug: Cilostazol; Drug: Acetylsalicylic acid; Drug: Clopidogrel
Sponsor: Otsuka Pharmaceutical Co., Ltd.
Active, not recruiting
An Intervention to Promote Healthy Behaviors in Homeless Youth

Condition: Substance Use Disorders
Intervention: Behavioral: Intervention to Promote Healthy Behaviors
Sponsors: University of Texas at Austin; Ohio State University
Recruiting
A Study in Healthy Adults to Evaluate the Safety and Immunogenicity of Different Doses of JNJ-63871860

Condition: Healthy
Interventions: Biological: ExPEC4V (4 : 4 : 4 : 4); Biological: ExPEC4V (4 : 4 : 4 : 8); Biological: ExPEC4V (8 : 8 : 8 : 8); Biological: ExPEC4V (8 : 8 : 8 : 16); Biological: ExPEC4V (16 : 16 : 16 : 16); Drug: Placebo
Sponsor: Janssen Research & Development, LLC
Active, not recruiting
The Effects of Antipsychotic Drugs on Brain Metabolism in Healthy Individuals

Condition: Healthy
Intervention: Drug: Olanzapine
Sponsor: Mclean Hospital
Recruiting
A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of MHAB5553A in Healthy Volunteers

Condition: Healthy Volunteer
Interventions: Drug: MHAB5553A; Drug: Matching placebo
Sponsor: Genentech, Inc.
Completed
Phase 1 Study(Additional) of URC102 in Healthy Subjects

Condition: Healthy
Interventions: Drug: Placebo; Drug: URC102
Sponsor: JW Pharmaceutical
Completed
Pharmacokinetic Interaction Between Diltiazem and ACT-541468 in Healthy Subjects

Condition: Healthy Subjects
Interventions: Drug: ACT-541468; Drug: Diltiazem
Sponsor: Idorsia Pharmaceuticals Ltd.
Completed
Comparison of Retinal Oxygenation and Retinal Vessel Diameters in Healthy Subjects and Patients With Diabetic Retinopathy or Retinal Vein Occlusion Between DVA and Oxymap

Conditions: Healthy Subjects; Diabetic Retinopathy; Retinal Vein Occlusion
Interventions: Other: Dynamic Vessel Analyzer; Other: Oxymap T1
Sponsor: Medical University of Vienna
Completed
Human Plasma Fatty Acid Oscillations

Conditions: Nocturnal Eating-Drinking Syndrome; Healthy
Intervention:
Sponsor: University of Pennsylvania
Recruiting
Strong Hearts: Rural CVD Prevention

Conditions: Heart Disease; Cardiovascular Disease; Sedentary Lifestyle; Overweight; Obesity
Interventions: Behavioral: Strong Hearts, Healthy Communities; Behavioral: Strong Hearts, Healthy Women
Sponsors: Cornell University; Montana State University; Tufts University; Bassett Healthcare
Active, not recruiting
Xenon-129 Magnetic Resonance Imaging of Healthy Subjects: Hardware and Software Development and Reproducibility

Condition: Healthy Volunteers
Intervention: Other: Hyperpolarized Xenon MRI
Sponsors: Western University, Canada; London Health Sciences Centre
Recruiting
Study To Evaluate The Safety, Tolerability, And Pharmacokinetics Of Oral Pf-06650833 In Healthy Subjects

Condition: Healthy
Interventions: Drug: PF-06650833; Drug: Placebo
Sponsor: Pfizer
Completed
Healthy Eating and Active Living for Diabetes - Gestational Diabetes Mellitus

Condition: Diabetes Mellitus Gestational Previous Pregnancy
Intervention: Behavioral: Healthy Eating and Active Living for Diabetes - Gestational Diabetes Mellitus
Sponsor: Athabasca University
Completed
Longitudinal 3He Magnetic Resonance Imaging of Healthy Lung

Condition: Healthy
Interventions: Other: Hyperpolarized Helium-3; Device: MRI
Sponsor: Western University, Canada
Recruiting
A Study of Abemaciclib (LY2835219) in Healthy Participants With and Without Food

Condition: Healthy
Intervention: Drug: Abemaciclib
Sponsor: Eli Lilly and Company
Completed
Effect of Gefapixant (MK-7264/AF-219) on Cough Reflex Sensitivity in Healthy and Chronic Cough Participants (MK-7264-014)

Condition: Refractory Chronic Cough
Interventions: Drug: Gefapixant 100 mg; Drug: Placebo
Sponsor: Afferent Pharmaceuticals, Inc.
Completed
Open Label Crossover Study Pharmacokinetics (PK) Study in Healthy Volunteers Receiving Various Forms of Fentanyl

Condition: Healthy
Intervention: Drug: Fentanyl
Sponsor: Depomed
Completed
Single-Ascending Dose Study of BIIB054 in Healthy Participants and Early Parkinson's Disease

Conditions: Parkinson's Disease; Healthy
Interventions: Drug: BIIB054; Drug: Placebo
Sponsor: Biogen
Completed
PaTH Clinical Data Research Network (CDRN) Study of Healthy Lifestyles and Health Care

Condition: Weight
Intervention:
Sponsors: University of Pittsburgh; Temple University; Johns Hopkins University; Penn State University; Geisinger Clinic
Active, not recruiting
Study of PF614 Compared to OxyContin® in Healthy Volunteers

Condition: Healthy
Interventions: Drug: PF614; Drug: Oxycodone extended-release; Drug: Naltrexone Hydrochloride
Sponsors: Ensysce Biosciences; PRA Health Sciences
Completed
Assessment of the Effect of Naltrexone on Lofexidine Single Dose Pharmacokinetics in Healthy Subjects

Condition: Healthy
Intervention: Drug: Lofexidine + Naltrexone
Sponsors: US WorldMeds LLC; National Institute on Drug Abuse (NIDA)
Completed
Study to Evaluate Taste Profile of Different JNJ-53718678 Oral Liquid Formulations in Healthy Participants

Condition: Healthy
Interventions: Drug: Formulation A; Drug: Formulation B; Drug: Formulation C; Drug: Formulation D; Drug: Formulation E; Drug: Formulation F; Drug: Formulation M1; Drug: Formulation M2; Drug: Formulation M3; Drug: Formulation N1; Drug: Formulation N2; Drug: Formulation N3
Sponsor: Janssen Sciences Ireland UC
Completed
A Study to Assess Safety Tolerability and Immunogenicity of Three Prime-boost Regimens of the Candidate Prophylactic Vaccines for Ebola in Healthy Adults

Condition: Healthy
Interventions: Biological: MVA-BN-Filo; Biological: Ad26.ZEBOV; Biological: Placebo
Sponsor: Janssen Vaccines & Prevention B.V.
Completed
Relative Bioavailability of Two Formulations of AKB-6548 and the Food Effect of a New Tablet in Healthy Adult Subjects

Condition: Healthy
Interventions: Drug: AKB-6548 tablet, reference formulation given in the fasted state; Drug: AKB-6548 tablet, test formulation given in the fasted state.; Drug: AKB-6548 tablet, test formulation given in the fed state
Sponsor: Akebia Therapeutics
Completed
VRC 208: Dose, Safety and Immunogenicity of a Recombinant Modified Vaccinia Virus Ankara Ebola Vaccine, VRC-EBOMVA079-00-VP (MVA-EbolaZ), Administered Alone or as a Boost to cAd3-Ebola Vaccines in Healthy Adults

Condition: Healthy Adult Immune Responses to Vaccine
Interventions: Biological: VRC-EBOMVA079-00-VP (MVA-EbolaZ); Biological: VRC-EBOADC069-00-VP (cAd3-EBO)
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Completed
Evaluation of Hypo-Safe Hypoglycaemia Alarm Device - the Pilot 2 Study - Healthy Subjects

Condition: Healthy
Intervention: Device: Hyposafe device
Sponsor: UNEEG Medical A/S
Completed
Safety and Pharmacokinetics of a Single ZMappTM Administration in Healthy Adult Volunteers

Condition: Healthy
Intervention: Drug: ZMAPP
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Withdrawn
Healthy Start to Increase Physical Activity and Improve Healthy Eating in Early Childcare Centres

Condition: Pediatric Obesity
Intervention: Behavioral: Healthy Start
Sponsors: Université de Sherbrooke; University of Saskatchewan
Completed
Ultrasound and Psychobiological Correlates of Female Sexual Function

Condition: Healthy
Intervention: Other: clitoral, transvaginal and transrectal ultrasound
Sponsor: University of Florence
Recruiting
Study in Healthy Volunteers to Evaluate the Efficacy and Safety of CR6261 in an H1N1 Influenza Healthy Human Challenge Model

Condition: H1N1 Influenza Healthy Volunteers
Interventions: Biological: CR6261; Biological: Placebo
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting
A Study to Evaluate the Effect of Increased Stomach pH on Evacetrapib in Healthy Participants

Condition: Healthy
Interventions: Drug: Evacetrapib; Drug: Omeprazole
Sponsor: Eli Lilly and Company
Completed
Delays to Influence Snack Choice

Condition: Food Choice
Interventions: Other: Time delays on delivery of less healthy snacks; Other: 25%/$0.25 discount on healthy snacks; Other: 25%/$0.25 tax on less healthy snacks
Sponsor: Rush University Medical Center
Completed
A Study to Evaluate Pharmacokinetic (PK) and Safety of GSK1265744 in Subjects With Hepatic Impairment and Control Healthy Volunteers

Condition: HIV Infections
Intervention: Drug: GSK1265744 30mg
Sponsors: ViiV Healthcare; GlaxoSmithKline
Completed
Assess the Effect of Zolpidem, Silenor & Placebo on Arousability, Ataxia/Balance & Cognition in Healthy Volunteers

Condition: Healthy
Interventions: Drug: Silenor 6 mg; Drug: zolpidem 10 mg; Drug: Placebo
Sponsors: Pernix Theraputics LLC; Henry Ford Hospital
Completed
The Influence of Histo-blood Group Antigen Polymorphism on the Composition of the Microbiota

Condition: Microbiota Analysis in Healthy Subjects
Intervention: Other: Healthy Adults
Sponsors: University of Florida; National Institute of Allergy and Infectious Diseases (NIAID)
Not yet recruiting
Healthy Families Healthy Forces Study

Conditions: Overweight; Obesity
Interventions: Behavioral: Healthy Weight for Living (HWL); Behavioral: Current Best Practice (CBP)
Sponsors: Tufts University; United States Army Research Institute of Environmental Medicine
Active, not recruiting
Susceptibility to Infections in Ataxia Telangiectasia

Conditions: Ataxia Telangiectasia; Infections; Immunodeficiency; Lung Disease
Interventions: Procedure: Blood collection; Procedure: Lung function measurement; Behavioral: Symptom diary
Sponsors: Johann Wolfgang Goethe University Hospital; CSL Behring
Completed
Our Year of Healthy Living (Formative Research & Intervention)

Condition: Obesity
Intervention: Behavioral: Healthy Me, Healthy We
Sponsors: University of North Carolina, Chapel Hill; National Heart, Lung, and Blood Institute (NHLBI)
Completed
A Study of LY2835219 in Healthy Participants

Condition: Healthy Volunteers
Interventions: Drug: LY2835219; Drug: ¹³C₈-LY2835219
Sponsor: Eli Lilly and Company
Completed
Bioequivalence Trial of Liquid Versus Freeze-Dried Pergoveris® in Pituitary Suppressed Healthy Premenopausal Female Subjects

Condition: Healthy
Interventions: Drug: Liquid pergoveris; Drug: Freeze-dried pergoveris
Sponsor: Merck KGaA
Completed
Study to Evaluate the Effects of Tramadol Hydrochloride on Cardiac Repolarization in Healthy Participants

Condition: Healthy
Interventions: Drug: Tramadol HCl; Drug: Moxifloxacin 400 mg; Drug: Tramadol HCl Placebo; Drug: Moxifloxacin Placebo
Sponsors: Janssen Scientific Affairs, LLC; Valeant Pharmaceuticals International, Inc.; Cipher Pharmaceuticals Inc.
Completed
A Family-Focused Intervention for Asian American Male Smokers

Conditions: Smoking Cessation; Family; Health Behavior
Interventions: Behavioral: Quit Smoking for a Healthy Family; Behavioral: Healthy Living
Sponsors: University of California, San Francisco; University of California, Davis; Chinese Community Health Resource Center; Immigrant Resettlement & Cultural Center; Vietnamese Voluntary Foundation, Inc.; Southeast Asian Community Center
Active, not recruiting
A Study of the Safety, Blood Levels and Biological Effects of GBT440 in Healthy Subjects and Subjects With Sickle Cell Disease

Conditions: Healthy Subjects; Sickle Cell Disease
Interventions: Drug: GBT440; Drug: Placebo
Sponsor: Global Blood Therapeutics
Completed
Relative Bioavailability Trial of L-Praziquantel in Healthy Volunteers

Condition: Healthy
Interventions: Drug: MSC2499550A; Drug: Cysticide
Sponsor: Merck KGaA
Completed
Phase I Study to Assess Safety and Pharmacokinetics of GMI-1271 in Healthy Adult Subjects

Condition: Healthy Volunteers
Interventions: Drug: GMI-1271; Drug: Placebo; Drug: Enoxaparin Sodium (Lovenox®)
Sponsors: GlycoMimetics Incorporated; University of Michigan
Completed
Phase 3 Study to Evaluate the Immunogenicity and Safety of Inactivated Split Influenza Vaccine in Healthy Korea Children

Condition: Healthy
Interventions: Biological: IL-YANG FLU Vaccine Prefilled Syringe INJ.; Biological: VAXIGRIP Prefilled Syringe INJ.
Sponsor: Il-Yang Pharm. Co., Ltd.
Completed
Study of New Tablet Formulations and Suspension Formulation Compared to Current (1B) Formulation of BILR 355 BS in Healthy Male Volunteer Subjects

Condition: Healthy
Interventions: Drug: BILR 355 BS /1B, current low dose formulation; Drug: BILR 355 BS /1B, current high dose formulation; Drug: BILR 355 BS - Jet Milled (JM) + Sodium Dodecyl Sulfate (SDS) formulation; Drug: BILR 355 BS - Hammer Milled (HM) + Sodium Dodecyl Sulfate (SDS) formulation; Drug: BILR 355 BS - Suspension low dose; Drug: BILR 355 BS - Suspension high dose; Drug: Ritonavir
Sponsor: Boehringer Ingelheim
Completed
Multiple Rising Dose of BI 1181181 Given Orally in Young Healthy Male and Elderly Healthy Male/Female Volunteers

Condition: Healthy
Interventions: Drug: Matching placebo; Drug: BI 1181181 healthy elderly; Drug: BI 1181181 Healthy young
Sponsor: Boehringer Ingelheim
Terminated
A Study of LY2835219 in Healthy Participants

Condition: Healthy Volunteers
Interventions: Drug: LY2835219; Drug: Rifampin
Sponsor: Eli Lilly and Company
Completed
Investigating the Influence of Omeprazole on the Pharmacokinetics of Oral Semaglutide in Healthy Subjects

Conditions: Diabetes; Healthy
Interventions: Drug: semaglutide; Drug: Omeprazole
Sponsor: Novo Nordisk A/S
Completed
A Study Comparing the Pharmacokinetics and Tolerance of D-Gam® to Rhophylac® in Rh-D-negative Healthy Volunteers.

Condition: Healthy
Interventions: Biological: D-Gam® (human anti-D immunoglobulin); Biological: Rhophylac® (human anti-D immunoglobulin)
Sponsor: Bio Products Laboratory
Completed
A Comparison of the Pharmacokinetics, Safety and Tolerance of Two Formulations of a Liquid IVIg in Healthy Volunteers

Condition: Healthy
Intervention: Biological: Gammaplex® (Human Normal Immunoglobulin)
Sponsor: Bio Products Laboratory
Completed
A Study of LY3079514 in Healthy Participants

Condition: Healthy Volunteers
Interventions: Drug: LY3079514; Drug: Placebo
Sponsor: Eli Lilly and Company
Completed
Food-Effect Study in Healthy Participants

Condition: Healthy
Intervention: Drug: Lasmiditan
Sponsors: Eli Lilly and Company; CoLucid Pharmaceuticals
Completed
Safety, Tolerability, and Immunogenicity of the Ebola Chimpanzee Adenovirus Vector Vaccine (cAd3-EBO), VRC-EBOADC069-00-VP, in Healthy Adults

Condition: Healthy Adult Immune Responses to Vaccine
Interventions: Biological: VRC-EBOADC069-00-VP; Biological: VRC-EBOADC076-00-VP
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Completed
Targeting Pregnancy-related Weight Gain to Reduce Disparities in Obesity

Conditions: Pregnancy; Body Weight Changes; Behavioral; Obesity
Intervention: Behavioral: Healthy Lifestyle Group
Sponsors: Temple University; HRSA/Maternal and Child Health Bureau
Active, not recruiting
A Study of Evacetrapib in Healthy Japanese Participants

Condition: Healthy Volunteers
Intervention: Drug: Evacetrapib
Sponsor: Eli Lilly and Company
Completed
Evaluation of the Safety and Immunogenicity of Autologous Thrombosomes® in Healthy Human Subjects; A Microdose Escalation Study (Cohorts 1 - 4) and Repeat Microdose Immunogenicity Study (Cohort 5)

Condition: Healthy
Interventions: Biological: Thrombosomes; Biological: Placebo
Sponsors: Cellphire, Inc.; Department of Health and Human Services
Completed
Healthy Lifestyles After Stroke

Conditions: Stroke; Apoplexy; Cerebral Stroke; Cerebrovascular Accident; Cerebrovascular Accident, Acute; Cerebrovascular Apoplexy; Cerebrovascular Stroke; CVA; Stroke, Acute; Vascular Accident, Brain
Intervention: Behavioral: Healthy Lifestyle Training Program
Sponsors: University of British Columbia; Canadian Institutes of Health Research (CIHR); Heart and Stroke Foundation of Canada
Recruiting
Hyperpolarized Xenon-129 Lung Magnetic Resonance Imaging: Healthy Adult Volunteer Pilot Study

Condition: Healthy
Intervention:
Sponsor: The Hospital for Sick Children
Recruiting
A Multiple Increasing Dose Safety and Tolerability Study After Inhalation Administration of BIIX 1 XX in Healthy Male Volunteers

Condition: Healthy
Interventions: Drug: BIIX 1 XX - D1; Drug: BIIX 1 XX - D2; Drug: BIIX 1 XX - D3; Drug: Placebo
Sponsor: Boehringer Ingelheim
Terminated
A First in Human Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of a Intravenous (IV) Dose of GSK2831781 in Healthy Volunteers and Patients With Plaque Psoriasis

Condition: Psoriasis
Interventions: Biological: GSK2831781; Biological: Placebo
Sponsors: GlaxoSmithKline; Parexel
Completed
Dietary Methionine and Cysteine Restriction in Healthy Adults

Condition: Healthy
Intervention: Other: Sulfur amino acid restricted diet
Sponsors: Milton S. Hershey Medical Center; Orentreich Foundation for the Advancement of Science, Inc.
Completed
Pharmacokinetics and Safety Study of PT010 in Healthy Subjects

Condition: COPD
Interventions: Drug: PT010; Drug: PT009; Drug: Symbicort Turbohaler
Sponsor: Pearl Therapeutics, Inc.
Completed
Evaluation of [11C]RO6924963, [11C]RO6931643, and [18F]RO6958948 as Tracers for Positron Emission Tomography (PET) Imaging of Tau in Healthy and Alzheimer's Disease (AD) Participants

Condition: Alzheimer's Disease, Healthy Volunteer
Interventions: Drug: [11C]RO6924963; Drug: [11C]RO6931643; Drug: [18F]RO6958948
Sponsor: Hoffmann-La Roche
Completed
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ACT-451840 in Healthy Subjects (Part A)

Condition: Healthy
Interventions: Drug: ACT-451840 10 mg; Drug: ACT-451840 50 mg; Drug: ACT-451840 200 mg; Drug: ACT-451840 500 mg; Drug: ACT-451840 1000 mg; Drug: ACT-451840 (Dose to be determined); Drug: Placebo
Sponsor: Idorsia Pharmaceuticals Ltd.
Completed
A Study To Understand Safety And Plasma Concentrations Of PF-06669571 During And Following The Oral Administration Of Single And Multiple Doses Of PF-06669571 In Healthy Volunteers Under Fasted And Fed Conditions

Condition: Healthy
Intervention: Drug: PF-06669571
Sponsor: Pfizer
Completed
Safety, Pharmacokinetics and Pharmacodynamics of BIBR 1048 MS Capsule in Healthy Male Subjects of Japanese and Caucasian Origin

Condition: Healthy
Interventions: Drug: BIBR 1048 MS low dose; Drug: BIBR 1048 MS medium dose; Drug: BIBR 1048 MS high dose
Sponsor: Boehringer Ingelheim
Completed
Safety, Pharmacokinetics and Pharmacodynamics After Single Rising Oral Doses of BIBR 1048 MS as Capsules in Healthy Subjects of Japanese and Caucasian Origin

Condition: Healthy
Interventions: Drug: BIBR 1048 MS; Drug: Placebo of BIBR 1048 MS
Sponsor: Boehringer Ingelheim
Completed
Relative Bioavailability of Dabigatran and Atorvastatin in Healthy Male and Female Volunteers

Condition: Healthy
Interventions: Drug: Dabigatran; Drug: Atorvastatin
Sponsor: Boehringer Ingelheim
Completed
Placebo-controlled Single Dose Study to Evaluate Safety and Pharmacokinetics of GMI-1271 in Healthy Volunteers

Condition: Healthy Adult Subjects
Interventions: Drug: GMI-1271; Drug: Placebo
Sponsor: GlycoMimetics Incorporated
Completed
Turn up the HEAT - Healthy Eating and Activity Time in Summer Day Camps

Condition: Childhood Obesity
Intervention: Behavioral: Healthy Eating and Physical Activity
Sponsor: University of South Carolina
Completed
Study of Evacetrapib (LY2484595) and Warfarin in Healthy Participants

Condition: Healthy Volunteers
Interventions: Drug: Evacetrapib; Drug: Warfarin
Sponsor: Eli Lilly and Company
Completed
A Study of Evacetrapib With Selected Statins in Healthy Chinese Participants

Condition: Healthy Volunteers
Interventions: Drug: Evacetrapib; Drug: Simvastatin; Drug: Atorvastatin
Sponsor: Eli Lilly and Company
Completed
Influence of Dietary Omega-3 Fatty Acids in Various triOMEG Sausages on the HS-Omega-3 Index in Healthy Individuals

Condition: Healthy Volunteers
Interventions: Other: Sausage: Triomeg; Other: Sausage: Control
Sponsors: Clemens von Schacky; Südbayerische Fleischwaren GmbH
Completed
Pharmacokinetic, Safety, Tolerability and Immunogenicity Study of SB5 in Healthy Subjects

Condition: Healthy
Interventions: Biological: SB5; Biological: EU sourced Humira®; Biological: US sourced Humira®
Sponsor: Samsung Bioepis Co., Ltd.
Completed
Evaluation of the Healthy Relationships Plus Program for Youth

Condition: Mental Health Wellness 1
Interventions: Behavioral: Healthy Relationships Plus Program (HRPP); Behavioral: Control Condition (Classroom Activities)
Sponsors: Centre for Addiction and Mental Health; CAMH Foundation
Completed
Fludrocortisone in Healthy Volunteers (AFLUCO4)

Condition: Healthy Volunteers
Interventions: Drug: Fludrocortisone 100 μg; Drug: Fludrocortisone 200 μg; Drug: Fludrocortisone 400 μg; Drug: Placebo
Sponsor: Rennes University Hospital
Completed
Modulation of Visual-Spatial Learning in Healthy Older Adults by tDCS

Condition: Healthy Older Adults
Interventions: Device: tDCS; Behavioral: training
Sponsor: Charite University, Berlin, Germany
Completed
Study Evaluating the Safety, Tolerability, and Pharmacokinetics of Single Doses and Multiple Doses of BIIB059 in Healthy Volunteers and Participants With Systemic Lupus Erythematosus

Conditions: Systemic Lupus Erythematosus; Healthy Volunteers
Interventions: Drug: BIIB059; Drug: Placebo
Sponsor: Biogen
Completed
The Role of Complement Factor H Polymorphism in the Regulation of Choroidal Vascular Tone in Young Healthy Subjects

Condition: Age-Related Macular Degeneration
Intervention: Genetic: the polymerase chain reaction (PCR)
Sponsor: Medical University of Vienna
Recruiting
A Study to Compare the Oral Bioavailability of Single Doses of Two Vapendavir Drug Formulations in Healthy Volunteers

Condition: Healthy
Interventions: Drug: Vapendavir 300 mg tablet; Drug: Vapendavir 132 mg capsules
Sponsor: Biota Pharmaceuticals, Inc.
Completed
Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ACT-389949 in Healthy Subjects

Condition: Healthy Subjects
Interventions: Drug: ACT-389949 40 mg; Drug: ACT-389949 200 mg; Drug: ACT-389949 800 mg; Drug: ACT-389949 (Group C1 dose to be selected); Drug: ACT-389949 (Group C2 dose to be selected); Drug: Placebo
Sponsor: Idorsia Pharmaceuticals Ltd.
Completed
Pharmacokinetics of Sufentanil Sublingual Microtablet 30 mcg and 15 mcg in Healthy Subjects

Condition: Healthy
Interventions: Drug: Treatment Arm A: Sufenta®; Drug: Treatment B: Sufentanil SSM 30 mcg; Drug: Treatment C: SSM 15 mcg; Drug: Treatment D: SSM 30 mcg
Sponsor: AcelRx Pharmaceuticals, Inc.
Completed
Evaluating the Plasma, Epithelial Lining, and Alveolar Macrophage Concentrations of Intravenous Carbavance™ (RPX2014/RPX7009) in Healthy Adult Subjects

Condition: Healthy Subjects
Intervention: Drug: RPX7009 and RPX2014
Sponsor: Rempex Pharmaceuticals (a wholly owned subsidiary of The Medicines Company)
Completed
Sleep, Nutrition and Psychological Functioning in Kindergarten Children

Condition: Prevention Harmful Effects
Interventions: Behavioral: Healthy Sleep intervention; Behavioral: Healthy Nutrition intervention
Sponsors: Tel Aviv University; Israel Science Foundation
Active, not recruiting
A Thorough QTc Evaluation of the Effect of Semaglutide on Cardiac Repolarisation in Healthy Subjects

Conditions: Diabetes; Healthy
Interventions: Drug: semaglutide; Drug: placebo; Drug: moxifloxacin
Sponsor: Novo Nordisk A/S
Completed
A Study of LY2835219 in Healthy Participants

Condition: Healthy Volunteers
Intervention: Drug: LY2835219
Sponsor: Eli Lilly and Company
Completed
An Evaluation of Selected Responsible Fatherhood and Healthy Marriage Programs: Parents and Children Together

Conditions: Responsible Fatherhood; Healthy Marriage
Interventions: Behavioral: Responsible Fatherhood or Healthy Marriage Program; Behavioral: Other services in the community
Sponsors: Mathematica Policy Research, Inc.; Department of Health and Human Services
Active, not recruiting
Echocardiographic Analysis in Healthy Child.

Condition: Healthy Child
Intervention: Other: Echocardiography
Sponsor: University Hospital, Montpellier
Completed
Pharmacokinetics and Safety in Healthy Volunteers

Condition: Healthy
Interventions: Drug: BI 695501; Drug: adalimumab-EU source; Drug: adalimumab-US source
Sponsor: Boehringer Ingelheim
Completed
Effect of Herbs and Spices on Metabolic Regulation and Appetite in Healthy Subjects

Condition: Healthy
Interventions: Dietary Supplement: Spices 1; Dietary Supplement: Spices 2; Dietary Supplement: Spices 3; Dietary Supplement: Herbs 1; Dietary Supplement: Herbs 2; Dietary Supplement: Control drink
Sponsors: Lund University; Anti-Diabetic Food Centre
Completed
Glutamate, Brain Connectivity and Duration of Untreated Psychosis

Conditions: Schizophrenia; Psychosis; Schizoaffective Disorder
Intervention: Drug: Risperidone
Sponsor: University of Alabama at Birmingham
Recruiting
Broccoli Sprout Extracts in Healthy Volunteers: A Pilot Study of Nrf2 Pathway Modulation in Oral Mucosa

Condition: Healthy Subject
Intervention: Drug: Broccoli Sprout Extract (BSE)
Sponsors: Julie E. Bauman, MD, MPH; National Cancer Institute (NCI)
Completed
A Study Exmining the Effect of Multiple Doses of Bitopertin on the Single Dose Pharmacokinetics of Midazolam in Healthy Volunteers.

Condition: Healthy Volunteer
Interventions: Drug: Midazolam; Drug: bitopertin
Sponsor: Hoffmann-La Roche
Withdrawn
Tryptophan Requirement of Healthy School Age Children

Condition: Healthy
Intervention: Dietary Supplement: tryptophan
Sponsor: The Hospital for Sick Children
Completed
Analysis of 18F-AV-1451 PET Imaging in Cognitively Healthy, MCI and AD Subjects

Condition: Alzheimer's Disease
Interventions: Drug: florbetapir F 18; Drug: 18F-AV-1451
Sponsor: Avid Radiopharmaceuticals
Completed
The Effects of Prazosin on Dopamine in Healthy Humans: A PET Pilot Study

Condition: Healthy
Intervention: Drug: Prazosin Hydrochloride
Sponsors: Centre for Addiction and Mental Health; Ontario Lung Association; Pfizer
Completed
Glucose Metabolism and Quality of Life in Healthy Women

Condition: Healthy
Intervention:
Sponsor: Odense University Hospital
Completed
Study of Safety and Immunogenicity of HIV Vaccines in Healthy Volunteers

Conditions: Healthy Volunteer; HIV Vaccine
Interventions: Biological: Ad4-mgag; Biological: Ad4-EnvC150
Sponsors: National Institute of Allergy and Infectious Diseases (NIAID); PaxVax, Inc.
Active, not recruiting
Study to Evaluate the Pharmacokinetic Profile of Salbutamol Delivered by Unit Dose Dry Powder Inhaler (UD-DPI) Compared to the Diskus and Metered Dose Inhaler (MDI) in Healthy Volunteers.

Condition: Asthma
Interventions: Drug: Salbutamol Sulphate 150mcg UD-DPI Blister(1.6% blend); Drug: Salbutamol Sulphate 200mcg UD-DPI Blister(1.6% blend); Drug: Salbutamol Sulphate 250mcg UD-DPI Blister(1.6% blend); Drug: Salbutamol Sulphate 200mcg UD-DPI Blister(1% blend); Drug: Salbutamol Diskus 200mcg Blister; Drug: Salbutamol MDI 100mcg; Drug: Salbutamol Sulphate UD-DPI Blister (selected from Part A); Drug: Salbutamol Sulphate 250mcg UD-DPI Blister (selected from Part A); Drug: Salbutamol Diskus 200mcg Blister without activated charcoal; Drug: Salbutamol Diskus 200mcg Blister with activated charcoal; Drug: Salbutamol MDI 100mcg without activated charcoal; Drug: Salbutamol MDI 100mcg with activated charcoal
Sponsor: GlaxoSmithKline
Completed
Functional Brain Imaging in Healthy Volunteers to Study Cognitive Functions

Condition: Healthy Volunteers
Intervention:
Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)
Completed
A Study of [14C]-LY3023703 in Healthy Participants

Condition: Healthy Volunteers
Intervention: Drug: [^14C]-LY3023703
Sponsor: Eli Lilly and Company
Terminated
Phase 1 Single and Multiple Dose Study of FPA008 in Healthy Volunteers and Rheumatoid Arthritis Subjects

Conditions: Healthy; Rheumatoid Arthritis
Interventions: Drug: FPA008; Drug: Placebo
Sponsor: Five Prime Therapeutics, Inc.
Terminated
Linaclotide Acetate in Preventing Colorectal Cancer in Healthy Volunteers

Conditions: Colorectal Cancer; Healthy, no Evidence of Disease
Interventions: Drug: linaclotide acetate; Other: placebo; Other: pharmacological study; Other: laboratory biomarker analysis
Sponsors: Mayo Clinic; National Cancer Institute (NCI)
Completed
Phase 1 Study in Healthy Subjects to Evaluate the Effect of IPI-145 on the Pharmacokinetics of Midazolam

Condition: Healthy
Interventions: Drug: IPI-145; Drug: Midazolam
Sponsor: Verastem, Inc.
Completed
A Study of Carbon-14-Labeled LY2835219 ([^14C]-LY2835219) in Healthy Participants

Condition: Healthy Volunteers
Intervention: Drug: [^14C]-LY2835219
Sponsor: Eli Lilly and Company
Completed
Arginine Synthesis in Healthy Adult Humans

Condition: Healthy
Interventions: Other: 2-15N glutamine; Other: 15N2 arginine and 15N proline; Other: 1-13C glutamine
Sponsor: The Hospital for Sick Children
Completed
A Study of RO6870868 in Healthy Volunteers

Condition: Healthy Volunteer
Interventions: Drug: RO6870868; Drug: placebo
Sponsor: Hoffmann-La Roche
Completed
A Study of Evacetrapib and Rifampin in Healthy Participants

Condition: Healthy Volunteers
Interventions: Drug: Evacetrapib; Drug: Rifampin
Sponsor: Eli Lilly and Company
Completed
A Study of Evacetrapib (LY2484595) in Healthy Participants

Condition: Healthy Volunteers
Intervention: Drug: Evacetrapib
Sponsor: Eli Lilly and Company
Completed
A Study of Evacetrapib and Digoxin in Healthy Participants

Condition: Healthy Volunteers
Interventions: Drug: Evacetrapib; Drug: Digoxin
Sponsor: Eli Lilly and Company
Completed
Bone Mineral Content in Healthy Children

Condition: Healthy
Intervention: Device: No intervention
Sponsor: Arkansas Children's Hospital Research Institute
Active, not recruiting
Appraisal of MDCO-157 and Plavix® Pharmacokinetics and Pharmacodynamics in Healthy Volunteers With an Evaluation

Condition: Pharmacokinetics and Pharmacodynamics in Healthy Volunteers
Interventions: Drug: MDCO-157; Drug: PLAVIX
Sponsor: The Medicines Company
Completed
Collection of Saliva and/ or Peripheral Blood From Healthy Volunteers for Research

Conditions: Graft vs Host Disease; Healthy Volunteer; Graft-Versus-Host Disease
Intervention:
Sponsor: National Cancer Institute (NCI)
Completed
Safety and Effect of L. Reuteri on Biomarkers of Inflammation in Healthy Infants With Colic

Conditions: Gastrointestinal; Colic
Interventions: Biological: Lactobacillus reuteri; Biological: Placebo
Sponsor: The University of Texas Health Science Center, Houston
Completed
A Study of LY3084077 in Healthy Participants

Condition: Healthy Volunteers
Interventions: Drug: Placebo; Drug: LY3084077
Sponsor: Eli Lilly and Company
Completed
Study of Food on Evacetrapib (LY2484595) in Healthy Participants

Condition: Healthy Volunteers
Interventions: Drug: Evacetrapib; Other: High-fat Meal
Sponsor: Eli Lilly and Company
Completed
A Validation of a Genomics Based Prognostic in Severe Trauma

Conditions: Trauma; Complications; Multiple Organ Failure
Interventions: Other: Traumatized population; Other: Healthy Volunteers
Sponsors: University of Florida; National Institutes of Health (NIH); National Institute of General Medical Sciences (NIGMS); Massachusetts General Hospital
Active, not recruiting
Healthy Children, Strong Families: American Indian Communities Preventing Obesity

Conditions: Obesity; Overweight
Interventions: Behavioral: Healthy Children, Strong Families; Behavioral: Child Safety
Sponsors: University of Wisconsin, Madison; National Heart, Lung, and Blood Institute (NHLBI)
Completed
Arterial Stiffness in Chronic Kidney Disease

Condition: Chronic Kidney Disease
Intervention:
Sponsor: University of Edinburgh
Completed
A Human Phase I Absolute Bioavailability Study of PRT054021 in Healthy Male Volunteers

Condition: Healthy Subjects
Intervention: Drug: Betrixaban
Sponsor: Portola Pharmaceuticals
Completed
Phase 2 Healthy Volunteer Study to Evaluate the Ability of PRT064445 to Reverse the Effects of Several Blood Thinner Drugs on Laboratory Tests (Module 1 of 4)

Condition: Healthy Volunteers
Interventions: Combination Product: PRT064445/Apixaban; Combination Product: Placebo/Apixaban; Drug: Placebo
Sponsor: Portola Pharmaceuticals
Completed
A Study of Evacetrapib in Healthy Female Participants

Condition: Healthy Volunteers
Interventions: Drug: Ortho-Cyclen; Drug: Evacetrapib
Sponsor: Eli Lilly and Company
Completed
Testing the AVI-7100 Flu Drug in Healthy Volunteers

Condition: Influenza
Intervention: Drug: AVI-7100 versus placebo
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Completed
DO-HEALTH / Vitamin D3 - Omega3 - Home Exercise - Healthy Ageing and Longevity Trial

Condition: Improve Healthy Ageing in Seniors; Prevent Disease at Older Age
Interventions: Drug: Vitamin D3; Drug: Omega 3 fatty acids; Procedure: Strength Home Exercise; Procedure: Flexibility Home Exercise
Sponsors: University of Zurich; Recruitment Partners; University of Geneva, Switzerland; University of Basel; University Hospital, Toulouse, France (Prof. Bruno Vellas, MD); Charite University, Berlin, Germany; Medical University Innsbruck; University of Coimbra, Portugal (Prof. José daSilva, MD); Other University Partners; University of Sheffield; University of Manchester, UK (Prof. David Felson, MD MPH); Max Rubner University, Germany (Prof. Bernhard Watzl, PhD); Technische Universität Dresden; Impact Partner; International Osteoporosis Foundation (IOF; Prof. John Kanis, MD); SME Partners; Ferrari Data Solutions GmBH, Switzerland (Stephen M. Ferrari; direct data entry platform); Gut Pictures, Switzerland (Benno Gut; animated exercise video); NOVAMEN, France (Sandrine Rival; logistic management partner); Pharmalys, UK (Marieme Ba; monitoring partner); Industry Partners; DSM Nutritional Products (Dr. Elisabeth Stöcklin PhD, Dr. Manfred Eggersdorfer PhD); Nestlé (Michaela Höhne PhD, Irène Corthesy PhD); Roche Diagnostics; Funding within Framework 7 research program of the European Commission (project 278588); Further collaborators and advisors at website do-health.eu
Completed
A Multiple Dose Study of LY2541546 in Healthy Postmenopausal Women

Condition: Healthy
Interventions: Drug: LY2541546 - SC; Drug: LY2541546 - IV; Drug: Placebo - SC; Drug: Placebo - IV
Sponsor: Eli Lilly and Company
Completed
A Study in Healthy Adults and Adult Subjects With Rheumatoid Arthritis to Evaluate the Safety, Tolerability and Pharmacokinetics After Multiple Doses of ABT-494

Condition: Rheumatoid Arthritis
Interventions: Drug: ABT-494; Drug: Placebo; Drug: Tofacitinib
Sponsor: AbbVie (prior sponsor, Abbott)
Completed
A Study of LY3053102 in Healthy Participants

Condition: Healthy Volunteers
Interventions: Drug: LY3053102; Drug: Placebo
Sponsor: Eli Lilly and Company
Completed
A Study of Evacetrapib in Healthy Participants

Condition: Healthy Volunteers
Interventions: Drug: Evacetrapib; Drug: Gemfibrozil
Sponsor: Eli Lilly and Company
Completed
Efficacy of the Female Athlete Body Project (FAB)

Conditions: Eating Disorders; Female Athlete Triad
Interventions: Behavioral: Healthy Weight; Other: Brochure
Sponsors: Pennington Biomedical Research Center; National Institute of Mental Health (NIMH)
Active, not recruiting
Quercetin PK/PD Study in Healthy Adults and Patients With Hypercoagulable States

Condition: Healthy
Intervention: Drug: isoquercetin or quercetin
Sponsor: Beth Israel Deaconess Medical Center
Active, not recruiting
The Effect of Watching a Television Show on the Liking of Snack Foods

Condition: Measure Grams and Kcals of Snack Foods Consumed in Each Condition
Interventions: Other: Healthy Foods; Other: Unhealthy Snack Foods
Sponsor: The University of Tennessee, Knoxville
Completed
Ascending Single Doses of AMG 334 in Healthy Subjects and Migraine Patients

Condition: Migraine
Intervention: Drug: AMG 334
Sponsor: Amgen
Completed
Oral Nitrite and Nitrate in Healthy Normal Volunteer Adults

Condition: Focus of Study of Healthy Adults
Interventions: Drug: 15Nitrogen(15N)-labeled sodium nitrite; Drug: 15Nitrogen(15N)-labeled sodium nitrate
Sponsor: Gladwin, Mark, MD
Completed
A Randomized, Two-way, Crossover Study to Estimate the Relative Bioavailability of a Controlled-release Formulation of Oxycodone (40 mg) With Sequestered Naltrexone Compared With Immediate-release Oxycodone Tablets (20 mg) in Healthy Volunteers

Condition: Healthy
Interventions: Drug: Oxycodone controlled-release test formulation; Drug: Immediate-release reference drug
Sponsor: Pfizer
Completed
Dating Matters: Strategies to Promote Healthy Teen Relationships

Conditions: Teen Dating Violence; Healthy Dating Relationship Behaviors
Interventions: Behavioral: Dating Matters Comprehensive Approach; Behavioral: Standard of Care Safe Dates Approach
Sponsors: Centers for Disease Control and Prevention; NORC at the University of Chicago; Ogilvy Public Relations; Alameda County Public Health Department; Baltimore City Health Department; Broward County Health Department; Chicago Department of Public Health
Active, not recruiting
Safety and Pharmacokinetics of Single and Multiple Ascending Doses of 3K3A-APC in Healthy Adult Volunteers

Condition: Healthy
Interventions: Biological: 3K3A-APC, diluted in 0.9% sodium chloride in water; Drug: 0.9% NaCl in water
Sponsor: ZZ Biotech, LLC
Completed
A Single Dose Study of LY3023703 in Healthy Participants

Condition: Healthy Volunteers
Interventions: Drug: LY3023703; Drug: Placebo; Drug: Celecoxib
Sponsor: Eli Lilly and Company
Completed
The Effects of the Direct Acting Antiviral Agent Boceprevir on the Pharmacokinetics of Maraviroc in Healthy Volunteers

Condition: Healthy
Interventions: Drug: Maraviroc (5 days); Drug: Maraviroc and boceprevir (14 days)
Sponsors: Centre hospitalier de l'Université de Montréal (CHUM); Université de Montréal; McGill University Health Center; Toronto General Hospital
Completed
New Infant Formula Trial in Healthy Term Subjects on Growth, Body Composition, Tolerance and Safety

Condition: Healthy
Interventions: Other: Test Product; Other: Control Product 1; Other: Control Product 2
Sponsors: Danone Asia Pacific Holdings Pte, Ltd.; Nutricia Research
Active, not recruiting
Healthy Habits, Happy Homes: An Intervention to Improve Household Routines for Obesity Prevention

Condition: Obesity
Interventions: Behavioral: Home-Based Health Coaching; Behavioral: Mailed materials
Sponsors: Harvard Pilgrim Health Care; Centers for Disease Control and Prevention; Harvard School of Public Health
Completed
Safety Study of Mibefradil When Given Four Times a Day in Healthy Volunteers

Condition: Healthy
Interventions: Drug: mibefradil; Other: Placebo
Sponsors: Cavion, Inc.; Celerion; Dana-Farber Cancer Institute; LifeWatch Services, Inc.
Completed
A Comparison of the Safety and Immunogenicity of Various Schedules of Dengue Vaccine in Healthy Adult Volunteers

Condition: Healthy
Interventions: Biological: Takeda's Tetravalent Dengue Vaccine Candidate (TDV); Biological: TDV New Formulation; Drug: Placebo; Drug: New Formulation Placebo
Sponsor: Takeda
Completed
Healthy Home Offerings Via the Mealtime Environment (HOME) Plus

Condition: Obesity
Intervention: Behavioral: HOME Plus intervention
Sponsors: University of Minnesota - Clinical and Translational Science Institute; National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Completed
Healthy4Baby: Preventing Postpartum Weight Retention Among Low-Income, Black Women

Conditions: Pregnancy; Weight Loss; Behavioral; Obesity
Intervention: Behavioral: Healthy Lifestyle Group
Sponsors: Temple University; National Heart, Lung, and Blood Institute (NHLBI)
Completed
A Study of LY3025876 in Healthy Volunteers

Condition: Healthy Volunteers
Interventions: Drug: LY3025876; Drug: Placebo
Sponsor: Eli Lilly and Company
Completed
Screening of Healthy Adults for Genetic Variations That Control Fatty Acid Processing

Condition: Healthy
Intervention:
Sponsors: Wake Forest University Health Sciences; National Center for Complementary and Integrative Health (NCCIH); Office of Dietary Supplements (ODS)
Recruiting
Study to Investigate the Safety and Immunogenicity of a Tetravalent Chimeric Dengue Vaccine in Healthy Volunteers Between the Ages of 1.5 - 45 Years

Condition: Healthy
Interventions: Biological: TDV; Biological: Placebo
Sponsor: Takeda
Completed
Metabolic Effects of Olanzapine in Healthy Males

Condition: Healthy
Interventions: Drug: Olanzapine; Drug: Placebo
Sponsor: State University of New York at Buffalo
Completed
A Cross-Cultural Assessment of the Motivations of Healthy Participants in Phase I Research

Condition: Healthy Volunteer
Intervention:
Sponsor: National Institutes of Health Clinical Center (CC)
Completed
The Efficacy of Claritin in Healthy Subjects

Condition: Healthy
Intervention: Drug: Claritin
Sponsor: University of Chicago
Completed
A Study of LY2484595 in Healthy Subjects

Condition: Healthy Volunteers
Interventions: Drug: LY2484595 Reference Formulation (RF); Drug: LY2484595 spray-dried solid dispersion-propyl gallate (SDSD-PG)
Sponsor: Eli Lilly and Company
Completed
Study of the Pharmacokinetics and Pharmacodynamics of Crystalline PX-866 Tablets and Amorphous PX-866 Capsules in Healthy Volunteers

Condition: Healthy Volunteer
Intervention: Drug: PX-866
Sponsor: Cascadian Therapeutics Inc.
Completed
Study of the Tolerability of Ketorolac Tromethamine Following Intranasal Administration in Healthy Volunteers

Condition: Healthy Volunteers
Intervention: Drug: Ketorolac tromethamine
Sponsor: Egalet Ltd
Completed
A Study in Healthy Male Volunteers to Investigate Different Doses of a New Drug for the Treatment of Metabolic Diseases

Condition: Diabetes Mellitus, Type 2
Interventions: Drug: SRT3025; Drug: Placebo
Sponsor: Sirtris, a GSK Company
Completed
Manganese-Enhanced Magnetic Resonance Imaging in Healthy Volunteers and People With Multiple Sclerosis

Conditions: Multiple Sclerosis; Optic Neuritis
Intervention: Drug: Mangafodipir (Teslascan)
Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting
Investigation of Cortico-Rectal Pathways in Healthy Subjects and Constipated Patients

Conditions: Healthy Volunteers; Constipation
Interventions: Procedure: Cortical Evoked Potentials; Procedure: Transcranial motor evoked potentials; Procedure: Translumbosacral motor evoked potentials
Sponsor: Augusta University
Active, not recruiting
Effects of Systemically Administered Hydrocortisone on the Immune System in Healthy Volunteers

Conditions: Immunosuppression; Healthy; Healthy Subjects
Intervention:
Sponsor: National Heart, Lung, and Blood Institute (NHLBI)
Completed
Healthy Creations: Community Based Lifestyle Intervention Validation

Conditions: Overweight; Obesity
Intervention: Behavioral: Lifestyle Counseling
Sponsor: USDA Grand Forks Human Nutrition Research Center
Completed
A Study of LY3009104(Baricitinib) for Healthy Subjects

Condition: Healthy Volunteer
Interventions: Drug: LY3009104; Drug: Placebo
Sponsor: Eli Lilly and Company
Completed
Lorazepam, Diphenhydramine Hydrochloride, and Haloperidol Gel in Healthy Volunteers

Condition: Healthy
Interventions: Drug: lorazepam; Drug: diphenhydramine hydrochloride; Drug: haloperidol; Other: questionnaire administration; Other: laboratory biomarker analysis
Sponsors: Virginia Commonwealth University; National Cancer Institute (NCI); American Cancer Society, Inc.
Completed
Effects of Rosuvastatin on the Immune System in Healthy Volunteers With Normal Cholesterol

Conditions: Healthy Volunteers; Statins; Immune Modulation
Intervention:
Sponsor: National Heart, Lung, and Blood Institute (NHLBI)
Completed
Cellular and Molecular Characterization of the Immune Response in Healthy NIH Employees atBaseline, and After Immunization With the H1N1 or Seasonal Influenza Vaccines

Condition: Healthy Volunteers
Intervention:
Sponsor: National Heart, Lung, and Blood Institute (NHLBI)
Completed
The Intervention Nurses Start Infants Growing on Healthy Trajectories (INSIGHT) Study

Conditions: Infant; Obesity
Interventions: Behavioral: Child Safety Insights; Behavioral: Parenting Insights
Sponsors: Ian M. Paul, MD; National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Active, not recruiting
Gut Microbiota in the Healthy Population, Inflammatory Bowel Disease Patients, and Their Relatives

Condition: Inflammatory Bowel Disease
Intervention:
Sponsor: Chinese University of Hong Kong
Terminated
Pharmacokinetic Interaction Study of Efavirenz and American Ginseng in Healthy Volunteers

Condition: Healthy Volunteers
Intervention: Drug: American ginseng
Sponsors: Johns Hopkins University; National Center for Complementary and Integrative Health (NCCIH)
Completed
Collection of Bone Marrow From Healthy Volunteers and Patients for the Production of Clinical Bone Marrow Stromal Cell (BMSC) Products

Condition: Bone Marrow Stromal Cells
Intervention:
Sponsor: National Institutes of Health Clinical Center (CC)
Completed
Phase 1 Dosing Study of BAX 513 in Healthy Volunteers

Condition: Healthy Volunteers
Interventions: Other: Fucoidan (extract of Laminaria japonica); Other: Placebo
Sponsor: Baxalta now part of Shire
Completed
The Healthy Elderly Longevity Cohort

Condition: Healthy
Intervention:
Sponsor: Scripps Translational Science Institute
Recruiting
Repeat Dose Study of Controlled-Release Paroxetine Tablets and Immediate-Release Paroxetine Tablets in Healthy Japanese Male Subjects

Condition: Depressive Disorder
Intervention: Drug: Paroxetine CR and Paroxetine IR
Sponsor: GlaxoSmithKline
Completed
Collection of Blood, Bone Marrow, and Buccal Mucosa Samples From Healthy Volunteers for Center for Human Immunology, Autoimmunity, and Inflammatory Diseases (CHI) Laboratory Research Studies

Condition: Healthy Volunteers
Intervention:
Sponsor: National Heart, Lung, and Blood Institute (NHLBI)
Completed
Investigation of Dietary Absorptive Capacity of Fructans in Healthy Subjects - A Dose Response Study

Condition: Healthy Volunteers
Interventions: Dietary Supplement: Fructan - 7.5; Dietary Supplement: Fructan - 10; Dietary Supplement: Fructan - 12.5; Dietary Supplement: Fructan -- 5 grams
Sponsors: Augusta University; American Gastroenterological Association Foundation
Completed
Single Dose Study of Controlled-Release Paroxetine Tablets in Healthy Japanese Male Subjects

Condition: Depressive Disorder
Interventions: Drug: Paroxetine 12.5 milligrams tablet; Drug: Paroxetine 25 milligrams tablet; Drug: Paroxetine 50 milligrams tablet
Sponsor: GlaxoSmithKline
Completed
An Exploratory Evaluation of Biomarkers in Blister Fluid in Healthy Volunteers and Irradiated Skin

Conditions: Breast Cancer; Healthy Volunteer; Prostate Cancer
Intervention:
Sponsor: National Cancer Institute (NCI)
Completed
Healthy Volunteers Study of the Effects of Olanzapine and Ziprasidone

Conditions: Hyperglycemia; Hyperlipidemia
Interventions: Drug: Olanzapine; Drug: Ziprasidone
Sponsors: Washington University School of Medicine; Pfizer
Completed
Study to Evaluate Whether BLI-489 Can be Safely Tolerated by Healthy Subjects Given Multiple Doses

Condition: Healthy
Interventions: Drug: BLI-489; Drug: placebo
Sponsor: Wyeth is now a wholly owned subsidiary of Pfizer
Completed
Fatigue in Healthy Individuals

Conditions: Healthy Volunteer; Fatigue; Depression
Intervention:
Sponsor: National Institute of Nursing Research (NINR)
Completed
Bioavailability, Pharmacokinetics and Safety Evaluation of Phencynonate Hydrochloride in Healthy Volunteers

Condition: Healthy
Intervention: Drug: Phencynonate hydrochloride
Sponsor: PhytoHealth Corporation
Completed
Study Evaluating Single Doses of BLI-489 in Healthy Japanese Male Subjects

Condition: Healthy
Interventions: Drug: BLI-489; Drug: Placebo
Sponsor: Wyeth is now a wholly owned subsidiary of Pfizer
Completed
Fostering Healthy Futures Efficacy Trial for Preadolescent Youth in Foster Care

Condition: Child Abuse
Interventions: Other: Assessment; Behavioral: Fostering Healthy Futures (FHF)
Sponsors: University of Colorado, Denver; National Institute of Mental Health (NIMH); The Kempe Foundation for the Prevention and Treatment of Child Abuse and Neglect
Active, not recruiting
Technical Development of Interventional Cardiovascular Magnetic Resonance Imaging in Normal Volunteers

Condition: Healthy
Intervention:
Sponsor: National Heart, Lung, and Blood Institute (NHLBI)
Recruiting
Pilot Study of ORG 25935 Modulation of Ketamine-induced Behavioral and Cognitive Effects in Healthy Male Subjects

Condition: Healthy
Interventions: Drug: Ketamine and Org 25935; Drug: Placebo and Ketamine
Sponsors: Yale University; Organon
Active, not recruiting
Seniors Health and Activity Research Program-Pilot

Condition: Cognitive Function
Interventions: Behavioral: Physical Activity Training; Behavioral: Cognitive Training; Behavioral: Healthy Aging Education
Sponsors: Wake Forest University Health Sciences; National Institute on Aging (NIA)
Completed
Food Effects of Single Oral Dose of 600mg TR-701

Condition: Healthy
Intervention: Drug: TR-701 600mg
Sponsor: Trius Therapeutics LLC
Completed
Ethnic Differences in Response to Topical Capsaicin: A Psychophysical Study on Healthy Subjects

Condition: Healthy
Interventions: Drug: Capsaicin; Drug: Placebo moisturizing cream
Sponsor: Wake Forest University
Completed
Studies of Skin Microbes in Healthy People and in People With Skin Conditions

Conditions: Atopic Dermatitis; Eczema; Ichthyosis Vulgaris
Intervention:
Sponsor: National Human Genome Research Institute (NHGRI)
Recruiting
Safety, Pharmacokinetics, and Pharmacodynamics of SD-101 in Healthy Normal Males

Condition: Healthy
Interventions: Drug: SD-101; Drug: placebo
Sponsor: Dynavax Technologies Corporation
Completed
Single Ascending Dose of GAP-134 as a 24-hour IV Infusion in Healthy Japanese Males

Condition: Arrhythmia
Intervention: Drug: GAP-134
Sponsor: Wyeth is now a wholly owned subsidiary of Pfizer
Completed
Epidemiology Controls Using Healthy Participants

Condition: Healthy
Intervention: Behavioral: Questionnaire
Sponsors: M.D. Anderson Cancer Center; National Cancer Institute (NCI); National Institutes of Health (NIH)
Active, not recruiting
Normal Immunological Parameters Among Healthy Volunteers in Kambila, Mali

Condition: Malaria
Intervention:
Sponsors: National Institute of Allergy and Infectious Diseases (NIAID); University of Bamako
Recruiting
Collection of Blood, Bone Marrow, and Buccal Mucosa Samples From Healthy Volunteers

Condition: Healthy
Intervention:
Sponsor: National Heart, Lung, and Blood Institute (NHLBI)
Recruiting
Pharmacokinetic Drug Interactions of AEGR-733 on Lipid-lowering Agents

Condition: Healthy
Interventions: Drug: atorvastatin; Drug: simvastatin; Drug: ezetimibe; Drug: fenofibrate; Drug: dextromethorphan; Drug: Extended Release Niacin
Sponsor: Aegerion Pharmaceuticals, Inc.
Completed
Collection and Distribution of Blood Samples From Healthy Donors for In Vitro Research at the NCI Frederick Cancer Research and Development Center

Condition: Healthy Donors
Intervention:
Sponsor: National Cancer Institute (NCI)
Enrolling by invitation
Study Of PHarmacogenetics in Ethnically Diverse Populations (SOPHIE Study)

Condition: Focus Groups
Intervention:
Sponsor: University of California, San Francisco
Active, not recruiting
Relatively Healthy Male Veterans Observed Over Time to See What Types of Diseases Develop

Condition: Healthy
Intervention:
Sponsor: VA Office of Research and Development
Active, not recruiting
AMD 3100 (Mozobil Plerixafor) to Mobilize Stem Cells for Donation

Condition: Healthy
Intervention: Drug: AMD3100 (Mozobil plerixafor)
Sponsor: National Heart, Lung, and Blood Institute (NHLBI)
Completed
Blood Component Collection From Patients With Rheumatic or Kidney Disease and Healthy Volunteers

Conditions: Rheumatic Diseases; Healthy Volunteers
Intervention:
Sponsor: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Recruiting
Salivary Evaluation in Healthy Volunteers

Conditions: Healthy; Salivary Gland Disease
Intervention:
Sponsor: National Institute of Dental and Craniofacial Research (NIDCR)
Completed

Find Research Studies for Healthy Volunteers in Alberta

Welcome to Paid Research Studies