Welcome to Paid Research Studies




  • Condition:   Middle-ear Barotrauma
    Interventions:   Other: flight/diving simulation;   Other: ET function testing at ambient pressure;   Other: nasal video-endoscopy
    Sponsors:   University of Pittsburgh;   National Institute on Deafness and Other Communication Disorders (NIDCD)
    Recruiting

  • Conditions:   Ear Infection;   Otitis Media
    Intervention:   Device: Solo TympanostomyTube Device
    Sponsor:   AventaMed DAC
    Recruiting

  • Conditions:   Ear Infection;   Otitis Media
    Intervention:   Device: Hummingbird Tympanostomy Tube System (H-TTS)
    Sponsor:   Preceptis Medical, Inc.
    Recruiting

  • Condition:   Otitis Media
    Intervention:   Drug: Ofloxacin otic solution
    Sponsor:   Boston Children’s Hospital
    Not yet recruiting

  • Condition:   Otitis
    Interventions:   Procedure: general practice follow-up;   Procedure: ear-nose-throat (ENT) specialist follow-up
    Sponsors:   Norwegian University of Science and Technology;   St. Olavs Hospital;   Alesund Hospital;   Kristiansund Hospital;   Molde Hospital;   Helse Stavanger HF;   Sykehuset Innlandet HF;   University Hospital of North Norway
    Recruiting

  • Conditions:   Glue Ear;   Tube Disorders Eustachian
    Intervention:   Procedure: Balloon Eustachian Tuboplasty (BET)
    Sponsor:   Medical University of Vienna
    Recruiting

  • Condition:   Prominent Ears
    Intervention:   Device: EARFOLD®
    Sponsor:   Allergan
    Recruiting

  • Condition:   Otitis Media
    Intervention:   Device: PhotoniCare TOMi Scope
    Sponsors:   PhotoniCare, Inc.;   Carle Foundation Hospital;   Children's National Health System;   National Institute on Deafness and Other Communication Disorders (NIDCD)
    Recruiting

  • Conditions:   Otitis Media With Effusion;   Probiotics;   Adenoid Vegetations
    Intervention:   Dietary Supplement: Probactiol Mini
    Sponsor:   University Hospital, Antwerp
    Recruiting

  • Conditions:   Cleft Palate;   Tube Disorders Eustachian;   Velopharyngeal Incompetence Due to Cleft Palate;   Velopharyngeal Insufficiency
    Interventions:   Device: EarPopper;   Device: EMST150
    Sponsors:   Noel Jabbour;   National Institute on Deafness and Other Communication Disorders (NIDCD)
    Not yet recruiting

  • Condition:   Otitis Media
    Interventions:   Behavioral: Video;   Behavioral: Pamphlet
    Sponsor:   Hamilton Health Sciences Corporation
    Recruiting

  • Conditions:   Ear Deformities, Acquired;   Ear; Deformity, Congenital;   Microtia;   Nose Deformity;   Nose Deformities, Acquired;   Nose; Deformity, Congenital;   Nose; Deformity, Congenital, Bent or Squashed;   Nose; Deformity, Syphilitic, Congenital;   Nose; Deformity, Bone (Nose Cartilage);   Nose; Deformity, Septum, Congenital;   Nose; Deformity, Sinus (Wall), Congenital;   Nose; Deformity, Syphilitic, Late (Etiology);   Ear; Deformity, External;   Ear; Deformity, Auricle, Ear, Acquired;   Ear; Deformity, Auricle, Ear (Congenital)
    Intervention:   Device: AuryzoN Family of Devices
    Sponsors:   Reconstrata, LLC;   Johns Hopkins University
    Not yet recruiting

  • Condition:   Eustachian Tube Dysfunction
    Interventions:   Other: ET Stress test;   Other: Sonotubometry;   Other: Forced Response Test (FRT);   Other: Inflation Deflation Test (IDT);   Other: Maneuver Sequence;   Other: 9-Step Test;   Other: Tubomanometry;   Other: Videoendoscopic assessment of ETF;   Other: Pressure chamber ET test
    Sponsors:   University of Pittsburgh;   National Institute on Deafness and Other Communication Disorders (NIDCD)
    Recruiting

  • Condition:   Cerumen Impaction of Both Ears
    Intervention:   Device: Remo-Wax
    Sponsor:   Orion Corporation, Orion Pharma
    Not yet recruiting

  • Conditions:   Otitis Media;   Conductive Hearing Loss
    Intervention:   Behavioral: facilitator
    Sponsors:   Menzies School of Health Research;   The Balnaves Foundation;   The Northern Territory Government;   The Australian Government Department of Health
    Not yet recruiting

  • Conditions:   Pain, Postoperative;   Surgery, Oral
    Interventions:   Other: Licorice;   Other: Sugar water
    Sponsors:   Medical University of Vienna;   The Cleveland Clinic
    Recruiting

  • Condition:   Otitis Media
    Intervention:   Device: Hummingbird Tympanostomy Tube System
    Sponsor:   Preceptis Medical, Inc.
    Recruiting

  • Condition:   Acute Otitis Media
    Interventions:   Drug: OP0201 20mg per day+Amoxicillin-clavulanate;   Drug: Placebo 0mg per day+Amoxicillin-clavulanate
    Sponsor:   Novus Therapeutics, Inc
    Recruiting

  • Condition:   Acute Otitis Media
    Interventions:   Dietary Supplement: Lactobacillus salivarius PS7 during 6 months;   Dietary Supplement: Lactobacillus salivarius PS7 during 3 months;   Dietary Supplement: placebo
    Sponsors:   ProbiSearch SL;   Casen Recordati S.L.
    Recruiting

  • Condition:   Otitis Media With Effusion
    Interventions:   Drug: Fluticasone Nasal;   Drug: Anti Histamine plus Nasal decongestents;   Drug: Steroid Drug
    Sponsor:   Lumbini Medical College
    Not yet recruiting

  • Conditions:   Recurrent Acute Otitis Media;   Acute Otitis Media
    Intervention:   Device: EarPopper
    Sponsor:   Northwell Health
    Recruiting

  • Condition:   Otitis Media
    Intervention:   Device: Ventilation tube treatment
    Sponsors:   Zealand University Hospital;   Government of Greenland, Agency for Health and Prevention;   Copenhagen Trial Unit, Center for Clinical Intervention Research
    Recruiting

  • Condition:   Acute Otitis Media
    Interventions:   Other: Acute Otitis Media Choice Decision Aid;   Other: Usual Care
    Sponsor:   Mayo Clinic
    Recruiting

  • Conditions:   Microtia, Congenital;   Microtia;   Anesthesia, Local;   Anesthesia
    Intervention:   Procedure: Erector Spinae Plane Block
    Sponsor:   Stanford University
    Not yet recruiting

  • Condition:   Acute Otitis Media
    Interventions:   Dietary Supplement: Biokult;   Dietary Supplement: Placebo
    Sponsors:   Probiotics International Ltd.;   Sprim Advanced Life Sciences
    Recruiting

  • Condition:   Vestibular Disorder
    Interventions:   Behavioral: Vestibular Exercise Intervention;   Behavioral: Standard of Care
    Sponsor:   University of Pittsburgh
    Recruiting

  • Condition:   Vestibular Diseases
    Interventions:   Device: Vestibular Rehabilitation/Balance Belt;   Other: Standard Vestibular Rehabilitation
    Sponsor:   Boston Children’s Hospital
    Recruiting

  • Condition:   Hearing Loss
    Interventions:   Other: Current Primary Care Referral Process;   Other: Telemedicine Referral Process
    Sponsors:   Norton Sound Health Corporation;   Duke University;   Johns Hopkins University;   Patient-Centered Outcomes Research Institute
    Recruiting

  • Condition:   Otomycosis
    Interventions:   Drug: 7-Day Miconazole Oil (Miconazole 2%);   Drug: 14-Day Miconazole Oil (Miconazole 2%);   Drug: 14-Day Placebo - Oil Vehicle
    Sponsors:   Hill Dermaceuticals, Inc.;   QST Consultations, Ltd.
    Recruiting

  • Conditions:   Acute Otitis Media;   URTI;   Dental Caries in Children
    Interventions:   Other: Xylitol syrup;   Other: Placebo
    Sponsors:   St. Michael's Hospital, Toronto;   The Hospital for Sick Children
    Recruiting

  • Condition:   Acute Otitis Media
    Intervention:   Other: procedures
    Sponsor:   Rochester General Hospital
    Recruiting

  • Condition:   Hearing Disorders
    Intervention:   Diagnostic Test: Audiometer
    Sponsor:   Assiut University
    Not yet recruiting

  • Conditions:   Hearing Disorders in Children;   Core Stabilization;   Respiratory Muscle Strength;   Respiratory Functions;   Postural Control
    Interventions:   Other: Core Stabilization Exercises;   Other: No Intervention
    Sponsor:   Bezmialem Vakif University
    Recruiting

  • Condition:   Hearing Loss, Sensorineural
    Intervention:   Device: MED-EL SYNCHRONY PIN Cochlear Implant
    Sponsor:   Med-El Corporation
    Not yet recruiting

  • Condition:   Hearing Loss, Bilateral
    Interventions:   Behavioral: Parent-Implemented Communication Intervention (PICT);   Other: No Intervention - Business-as-usual control
    Sponsors:   Northwestern University;   Ann & Robert H Lurie Children's Hospital of Chicago
    Not yet recruiting

  • Conditions:   Hearing Impairment;   Hearing Loss, Sensorineural
    Interventions:   Device: Oticon OpenSound Navigator speech enhancement algorithm;   Device: Oticon omni-directional microphone algorithm
    Sponsors:   Children's Hospital Medical Center, Cincinnati;   Oticon
    Recruiting

  • Condition:   Hearing Loss, Conductive
    Intervention:   Device: Bone Anchored Hearing Surgery
    Sponsor:   Oticon Medical
    Recruiting

  • Conditions:   Cytomegalovirus Congenital;   Hearing Loss;   Neurodevelopmental Disorders;   Immunogenicity;   Neonatal Death;   Stillbirth
    Intervention:  
    Sponsor:   University of Witwatersrand, South Africa
    Recruiting

  • Condition:   Hearing Loss
    Intervention:   Device: Otoacoustic emissions device
    Sponsor:   Assiut University
    Not yet recruiting

  • Condition:   Vestibular Abnormality
    Intervention:  
    Sponsor:   Assiut University
    Not yet recruiting

  • Condition:   Hearing Loss, Sensorineural
    Interventions:   Behavioral: Phonological Awareness;   Behavioral: Working Memory;   Behavioral: Phonological Awareness + Working Memory;   Behavioral: Active Control
    Sponsors:   Florida State University;   Northwestern University
    Recruiting

  • Conditions:   Sensorineural Hearing Loss;   Cytomegalovirus Infection
    Intervention:  
    Sponsor:   National Institute on Deafness and Other Communication Disorders (NIDCD)
    Recruiting

  • Conditions:   Implants, Cochlear;   Child;   Hearing Loss, Bilateral
    Intervention:   Device: Hybrid L24
    Sponsor:   Bruce J Gantz
    Recruiting

  • Conditions:   Hearing Loss;   Language Development;   Social Behavior
    Interventions:   Behavioral: augmentative and alternative communication technology;   Behavioral: Usual Care
    Sponsor:   Children's Hospital Medical Center, Cincinnati
    Recruiting

  • Condition:   Unilateral Hearing Loss
    Intervention:   Device: Hearing aid
    Sponsor:   Massachusetts Eye and Ear Infirmary
    Recruiting

  • Condition:   Auditory Processing Disorder
    Intervention:   Device: Bone-conduction headset
    Sponsor:   Children's Hearing Evaluation and Amplification Resource, Ltd.
    Not yet recruiting

  • Condition:   Deafness, Bilateral
    Interventions:   Behavioral: Parent-Child Early Approaches to Raising Language Skills;   Other: Standard Care Speech therapy
    Sponsors:   University of Miami;   National Institute on Deafness and Other Communication Disorders (NIDCD)
    Recruiting

  • Condition:   Cytomegalovirus Infection
    Interventions:   Other: Placebo;   Drug: Valganciclovir
    Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID)
    Recruiting

  • Condition:   Congenital Sensorineural Deafness
    Interventions:   Behavioral: Telemedicine;   Behavioral: In-person ART
    Sponsors:   University of Colorado, Denver;   National Institute on Deafness and Other Communication Disorders (NIDCD);   University of Colorado, Boulder
    Recruiting

  • Conditions:   Neurofibromatosis 2;   Dermatology/Skin - Other
    Intervention:   Other: no intervention
    Sponsor:   Centre Hospitalier Universitaire de Nice
    Recruiting

  • Conditions:   Sensory Disorders;   Autism;   Autism Spectrum Disorder;   Autism With High Cognitive Abilities;   Autistic Behavior;   Hyperacusis
    Interventions:   Behavioral: Exposure therapy;   Behavioral: Psycho-education;   Behavioral: Caregiver education/home program development
    Sponsor:   University of Florida
    Recruiting

  • Conditions:   Auditory Perceptual Disorders;   Stress Disorder
    Intervention:   Behavioral: Listening Project Protocol
    Sponsors:   University of North Carolina, Chapel Hill;   Australian Childhood Foundation
    Recruiting

  • Conditions:   Intraocular Retinoblastoma;   Hearing Loss
    Intervention:   Diagnostic Test: Distortion product otoacoustic emission measurement (DPOAE)
    Sponsor:   Memorial Sloan Kettering Cancer Center
    Recruiting

  • Conditions:   Hearing Loss;   Conductive Hearing Loss;   Atresia
    Intervention:   Device: Bone Achored Hearing surgery
    Sponsors:   Oticon Medical;   Karolinska University Hospital
    Recruiting

  • Conditions:   Unilateral Mixed Conductive and Sensorineural Hearing Loss (Diagnosis);   Sensorineural Hearing Loss, Unilateral With Normal Hearing on the Contralateral Side
    Intervention:   Device: Osseointegrated Steady State Implant
    Sponsor:   Cochlear
    Recruiting

  • Condition:   Hearing Loss
    Interventions:   Other: Current Primary Care Referral Process;   Other: Telemedicine Referral Process
    Sponsors:   Norton Sound Health Corporation;   Duke University;   Johns Hopkins University;   Patient-Centered Outcomes Research Institute
    Recruiting

  • Condition:   Hearing Loss, Bilateral (Causes Other Than Tumors)
    Intervention:   Device: Nucleus ABI541 Auditory Brainstem Implant
    Sponsor:   New York University School of Medicine
    Recruiting

  • Conditions:   Neuroectodermal Tumors, Primitive;   Liver Neoplasms;   Osteosarcoma;   Other Childhood Cancers Using Cisplatin-based Regimens
    Intervention:   Drug: N-Acetylcysteine
    Sponsor:   Children's Hospital Los Angeles
    Recruiting

  • Condition:   Auditory Processing Disorders
    Interventions:   Diagnostic Test: functional MRI;   Diagnostic Test: Automated Cortical Brainstem Auditory Evoked Potential;   Genetic: whole exome sequencing;   Diagnostic Test: Standard Cortical Brainstem Auditory Evoked Potential;   Diagnostic Test: multidisciplinary consultation
    Sponsor:   Assistance Publique - Hôpitaux de Paris
    Not yet recruiting

  • Conditions:   Neurofibromatosis 2;   Vestibular Schwannoma;   Meningioma;   Ependymoma;   Glioma
    Intervention:   Drug: Selumetinib
    Sponsors:   Children's Hospital Medical Center, Cincinnati;   AstraZeneca
    Recruiting

  • Conditions:   Wolfram Syndrome;   Diabetes Mellitus;   Optic Nerve Atrophy;   Ataxia
    Intervention:   Drug: dantrolene sodium
    Sponsors:   Washington University School of Medicine;   National Institutes of Health (NIH)
    Recruiting

  • Conditions:   Auditory Perceptual Disorders;   Stress Disorder
    Intervention:   Behavioral: Listening Project Protocol
    Sponsors:   University of North Carolina, Chapel Hill;   ADD Centre© and Biofeedback Institute of Toronto©
    Recruiting

  • Conditions:   Mucopolysaccharidosis Disorders;   Hurler Syndrome;   Hunter Syndrome;   Maroteaux Lamy Syndrome;   Sly Syndrome;   Alpha-Mannosidosis;   Fucosidosis;   Aspartylglucosaminuria;   Glycoprotein Metabolic Disorders;   Sphingolipidoses;   Recessive Leukodystrophies;   Globoid Cell Leukodystrophy;   Metachromatic Leukodystrophy;   Niemann-Pick B;   Niemann-Pick C Subtype 2;   Sphingomyelin Deficiency;   Peroxisomal Disorders;   Adrenoleukodystrophy With Cerebral Involvement;   Zellweger Syndrome;   Neonatal Adrenoleukodystrophy;   Infantile Refsum Disease;   Acyl-CoA Oxidase Deficiency;   D-Bifunctional Enzyme Deficiency;   Multifunctional Enzyme Deficiency;   Alpha-methylacyl-CoA Racmase Deficiency;   Mitochondrial Neurogastrointestingal Encephalopathy;   Severe Osteopetrosis;   Hereditary Leukoencephalopathy With Axonal Spheroids (HDLS; CSF1R Mutation);   Inherited Metabolic Disorders
    Interventions:   Biological: Stem Cell Transplantation;   Drug: IMD Preparative Regimen;   Drug: Osteopetrosis Only Preparative Regimen;   Drug: Osteopetrosis Haploidentical Only Preparative Regimen;   Drug: cALD SR-A (Standard-Risk, Regimen A);   Drug: cALD SR-B (Standard-Risk, Regimen B);   Drug: cALD HR-D (High-Risk, Regimen C);   Drug: cALD HR-D (High-Risk, Regimen D)
    Sponsor:   Masonic Cancer Center, University of Minnesota
    Recruiting

  • Condition:   Hearing Disorder
    Intervention:  
    Sponsor:   National Institute on Deafness and Other Communication Disorders (NIDCD)
    Recruiting

  • Conditions:   Deafness;   Hearing Loss;   Parenting;   Child Behavior
    Intervention:   Behavioral: Parent Training Intervention
    Sponsors:   Christina Studts;   National Institute on Deafness and Other Communication Disorders (NIDCD)
    Not yet recruiting

  • Condition:   Congenital Hearing Loss
    Intervention:   Behavioral: Navigator Guidance
    Sponsors:   University of Kentucky;   National Institute on Deafness and Other Communication Disorders (NIDCD);   National Institutes of Health (NIH)
    Not yet recruiting

  • Condition:   Congenital Deafness
    Intervention:   Behavioral: Phase duration
    Sponsor:   East Carolina University
    Not yet recruiting

  • Condition:   Conductive Hearing Loss
    Intervention:   Device: Bone conduction device (ADHEAR)
    Sponsor:   Medical University of Vienna
    Recruiting

  • Condition:   Hearing Loss, Cochlear
    Intervention:   Procedure: Electrocochleography
    Sponsor:   Guy's and St Thomas' NHS Foundation Trust
    Recruiting

  • Condition:   Tinnitus
    Intervention:   Other: Physical Therapy
    Sponsor:   VA Office of Research and Development
    Not yet recruiting

  • Conditions:   Bone Conduction Deafness;   Hearing Loss, Conductive
    Intervention:   Device: Adhesive bone conduction hearing aid (ADHEAR - Med El)
    Sponsor:   Dominik Riss
    Recruiting

  • Condition:   Conductive Hearing Loss
    Interventions:   Device: Adhear;   Device: Contact Mini (CM)
    Sponsor:   Dominik Riss
    Recruiting

  • Conditions:   Hearing Loss;   Cochlear Implant
    Intervention:   Other: Electrocochleography
    Sponsor:   Medical College of Wisconsin
    Recruiting

  • Conditions:   Hearing Loss, Conductive;   Hearing Loss, Unilateral
    Interventions:   Device: Adhear Bone Conduction System;   Device: Standard of Care
    Sponsors:   University of Miami;   Med-El Corporation
    Recruiting

  • Conditions:   Hearing Disorder;   Oral Mucosal Disease;   Pharyngeal Neoplasm;   Head and Neck Neoplasms;   Laryngeal Disease
    Intervention:  
    Sponsors:   National Institute on Deafness and Other Communication Disorders (NIDCD);   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
    Recruiting

  • Conditions:   Enlarged Vestibular Aqueduct;   Sensorineural Hearing Loss
    Intervention:  
    Sponsor:   Todd Otteson, MD, MPH, FAAP, FACS
    Recruiting

  • Conditions:   Language Impairment;   Hearing Loss
    Interventions:   Other: E-learning;   Device: Hearing aids fitting
    Sponsor:   Hospices Civils de Lyon
    Recruiting

  • Condition:   Deafness
    Interventions:   Other: Auditory steady-state response ASSR;   Other: Speech-ABR;   Other: Acoustic Change Complex ACC;   Other: P1-N1-P2 complex and Mismatch Negativity MMN
    Sponsor:   Hospices Civils de Lyon
    Recruiting

  • Condition:   Deafness
    Intervention:   Behavioral: Site selection
    Sponsor:   East Carolina University
    Not yet recruiting

  • Condition:   Deafness
    Intervention:   Behavioral: Electrode selection/electrode configuration
    Sponsor:   East Carolina University
    Not yet recruiting

  • Condition:   Deafness
    Intervention:   Behavioral: Auditory training
    Sponsor:   East Carolina University
    Not yet recruiting

  • Condition:   Benign Paroxysmal Positional Vertigo
    Intervention:   Diagnostic Test: Epley maneuver/Barbeque maneuver
    Sponsor:   University of Zurich
    Not yet recruiting

  • Condition:   Hearing Loss
    Intervention:   Device: Cochlear® Hearing Implants
    Sponsor:   Cochlear
    Recruiting

  • Condition:   Benign Paroxysmal Positional Vertigo (BPPV)
    Intervention:   Procedure: Canalith repositioning procedure
    Sponsor:   Chiang Mai University
    Recruiting

  • Conditions:   Angiokeratomas;   Chronic Kidney Disease;   Ocular Abnormalities;   Hearing Loss
    Intervention:  
    Sponsor:   Centogene AG Rostock
    Recruiting

  • Conditions:   Immunodeficiency;   Skeletal Abnormalities;   Deafness;   Mental Retardation;   Gingival Hypertrophy;   Facial Dysmorphism
    Intervention:  
    Sponsor:   Centogene AG Rostock
    Recruiting

  • Conditions:   Nephritis, Hereditary;   Hematuria-Nephropathy-Deafness Syndrome
    Intervention:  
    Sponsor:   Centogene AG Rostock
    Recruiting

  • Condition:   Usher Syndrome, Type 1B
    Intervention:  
    Sponsor:   Fondazione Telethon
    Recruiting

  • Condition:   Wolfram Syndrome
    Interventions:   Drug: Sodium Valproate 200Mg E/C Tablet;   Drug: Sodium Valproate matched placebo
    Sponsor:   University of Birmingham
    Recruiting

  • Conditions:   Smith-Lemli-Opitz Syndrome;   Cone-Rod Dystrophy;   Hearing Loss
    Interventions:   Drug: Antioxidants;   Drug: Cholesterol
    Sponsor:   University of Colorado, Denver
    Recruiting

  • Conditions:   Brain Tumor, Recurrent;   Vestibular Schwannoma;   Brainstem Neoplasm;   Brainstem Glioma
    Intervention:   Procedure: Intraoperative Monitoring during resection of brain tumor
    Sponsor:   University Hospital Tuebingen
    Recruiting

  • Conditions:   Acoustic Neuroma;   Labyrinthitis Ossificans;   Profound Hearing Impairment
    Intervention:   Device: MedEl Test Electrode Placer
    Sponsors:   Eric W. Sargent, MD;   Med-El Corporation
    Recruiting

  • Conditions:   Epilepsy; Seizure;   Neuromuscular Diseases;   Brain Malformation;   Intellectual Disability;   Autism Spectrum Disorder;   Hypotonia;   Inborn Errors of Metabolism;   Movement Disorders;   Genetic Disease;   Development Delay;   Chromosome Abnormality;   Hearing Loss;   Dysmorphic Features;   Skeletal Dysplasia;   Congenital Abnormality;   Microcephaly;   Macrocephaly
    Interventions:   Behavioral: Pre-visit prep;   Diagnostic Test: usual care + exome seq
    Sponsors:   University of North Carolina, Chapel Hill;   National Human Genome Research Institute (NHGRI);   East Carolina University;   Mission Health System, Asheville, NC
    Recruiting

  • Condition:   Vestibular Schwannoma
    Intervention:  
    Sponsor:   Haukeland University Hospital
    Recruiting

  • Conditions:   Vestibular Schwannoma;   Acoustic Neuroma;   Neurofibromatosis 2
    Interventions:   Drug: Aspirin;   Drug: Placebo
    Sponsors:   Massachusetts Eye and Ear Infirmary;   United States Department of Defense;   Massachusetts General Hospital
    Recruiting

  • Conditions:   Acute Leukemia;   Adenomatous Polyposis;   Adrenocortical Carcinoma;   AML;   BAP1 Tumor Predisposition Syndrome;   Carney Complex;   Choroid Plexus Carcinoma;   Constitutional Mismatch Repair Deficiency Syndrome;   Diamond-Blackfan Anemia;   DICER1 Syndrome;   Dyskeratosis Congenita;   Emberger Syndrome;   Familial Acute Myeloid Leukemia;   Familial Adenomatous Polyposis;   Fanconi Anemia;   Familial Cancer;   Familial Wilms Tumor;   Familial Neuroblastoma;   GIST;   Hereditary Breast and Ovarian Cancer;   Hereditary Paraganglioma-Pheochromocytoma Syndrome;   Hodgkin Lymphoma;   Juvenile Polyposis;   Li-Fraumeni Syndrome;   Lynch Syndrome;   MDS;   Melanoma Syndrome;   Multiple Endocrine Neoplasia Type 1;   Multiple Endocrine Neoplasia Type 2;   Neuroblastoma;   Neurofibromatosis Type 1;   Neurofibromatosis Type II;   Nevoid Basal Cell Carcinoma Syndrome;   Non Hodgkin Lymphoma;   Noonan Syndrome and Other Rasopathy;   Overgrowth Syndromes;   Pancreatic Cancer;   Peutz-Jeghers Syndrome;   Pheochromocytoma/Paraganglioma;   PTEN Hamartoma Tumor Syndrome;   Retinoblastoma;   Rhabdoid Tumor Predisposition Syndrome;   Rhabdomyosarcoma;   Rothmund-Thomson Syndrome;   Tuberous Sclerosis;   Von Hippel-Lindau Disease
    Intervention:  
    Sponsor:   St. Jude Children's Research Hospital
    Recruiting

  • Conditions:   Wolfram Syndrome;   Diabetes Mellitus;   Optic Nerve Atrophy;   Deafness;   Diabetes Insipidus;   Ataxia
    Intervention:  
    Sponsors:   Washington University School of Medicine;   American Diabetes Association;   National Institutes of Health (NIH)
    Recruiting

  • Conditions:   Sensorineural Hearing Loss;   Hearing Disorder;   Vestibular Disease
    Intervention:  
    Sponsor:   National Institute on Deafness and Other Communication Disorders (NIDCD)
    Recruiting

  • Conditions:   Eye Diseases Hereditary;   Retinal Disease;   Achromatopsia;   Bardet-Biedl Syndrome;   Bassen-Kornzweig Syndrome;   Batten Disease;   Best Disease;   Choroidal Dystrophy;   Choroideremia;   Cone Dystrophy;   Cone-Rod Dystrophy;   Congenital Stationary Night Blindness;   Enhanced S-Cone Syndrome;   Fundus Albipunctatus;   Goldmann-Favre Syndrome;   Gyrate Atrophy;   Juvenile Macular Degeneration;   Kearns-Sayre Syndrome;   Leber Congenital Amaurosis;   Refsum Syndrome;   Retinitis Pigmentosa;   Retinitis Punctata Albescens;   Retinoschisis;   Rod-Cone Dystrophy;   Rod Dystrophy;   Rod Monochromacy;   Stargardt Disease;   Usher Syndrome
    Intervention:  
    Sponsor:   Foundation Fighting Blindness
    Recruiting

  • Conditions:   Neurofibromatosis 1;   Neurofibromatosis 2;   Schwannomatosis
    Intervention:  
    Sponsor:   The Children's Tumor Foundation
    Recruiting

  • Conditions:   Rare Disorders;   Undiagnosed Disorders;   Disorders of Unknown Prevalence;   Cornelia De Lange Syndrome;   Prenatal Benign Hypophosphatasia;   Perinatal Lethal Hypophosphatasia;   Odontohypophosphatasia;   Adult Hypophosphatasia;   Childhood-onset Hypophosphatasia;   Infantile Hypophosphatasia;   Hypophosphatasia;   Kabuki Syndrome;   Bohring-Opitz Syndrome;   Narcolepsy Without Cataplexy;   Narcolepsy-cataplexy;   Hypersomnolence Disorder;   Idiopathic Hypersomnia Without Long Sleep Time;   Idiopathic Hypersomnia With Long Sleep Time;   Idiopathic Hypersomnia;   Kleine-Levin Syndrome;   Kawasaki Disease;   Leiomyosarcoma;   Leiomyosarcoma of the Corpus Uteri;   Leiomyosarcoma of the Cervix Uteri;   Leiomyosarcoma of Small Intestine;   Acquired Myasthenia Gravis;   Addison Disease;   Hyperacusis (Hyperacousis);   Juvenile Myasthenia Gravis;   Transient Neonatal Myasthenia Gravis;   Williams Syndrome;   Lyme Disease;   Myasthenia Gravis;   Marinesco Sjogren Syndrome(Marinesco-Sjogren Syndrome);   Isolated Klippel-Feil Syndrome;   Frasier Syndrome;   Denys-Drash Syndrome;   Beckwith-Wiedemann Syndrome;   Emanuel Syndrome;   Isolated Aniridia;   Beckwith-Wiedemann Syndrome Due to Paternal Uniparental Disomy of Chromosome 11;   Beckwith-Wiedemann Syndrome Due to Imprinting Defect of 11p15;   Beckwith-Wiedemann Syndrome Due to 11p15 Translocation/Inversion;   Beckwith-Wiedemann Syndrome Due to 11p15 Microduplication;   Beckwith-Wiedemann Syndrome Due to 11p15 Microdeletion;   Axenfeld-Rieger Syndrome;   Aniridia-intellectual Disability Syndrome;   Aniridia - Renal Agenesis - Psychomotor Retardation;   Aniridia - Ptosis - Intellectual Disability - Familial Obesity;   Aniridia - Cerebellar Ataxia - Intellectual Disability;   Aniridia - Absent Patella;   Aniridia;   Peters Anomaly - Cataract;   Peters Anomaly;   Potocki-Shaffer Syndrome;   Silver-Russell Syndrome Due to Maternal Uniparental Disomy of Chromosome 11;   Silver-Russell Syndrome Due to Imprinting Defect of 11p15;   Silver-Russell Syndrome Due to 11p15 Microduplication;   Syndromic Aniridia;   WAGR Syndrome;   Wolf-Hirschhorn Syndrome;   4p16.3 Microduplication Syndrome;   4p Deletion Syndrome, Non-Wolf-Hirschhorn Syndrome;   Autosomal Recessive Stickler Syndrome;   Stickler Syndrome Type 2;   Stickler Syndrome Type 1;   Stickler Syndrome;   Mucolipidosis Type 4;   X-linked Spinocerebellar Ataxia Type 4;   X-linked Spinocerebellar Ataxia Type 3;   X-linked Intellectual Disability - Ataxia - Apraxia;   X-linked Progressive Cerebellar Ataxia;   X-linked Non Progressive Cerebellar Ataxia;   X-linked Cerebellar Ataxia;   Vitamin B12 Deficiency Ataxia;   Toxic Exposure Ataxia;   Unclassified Autosomal Dominant Spinocerebellar Ataxia;   Thyroid Antibody Ataxia;   Sporadic Adult-onset Ataxia of Unknown Etiology;   Spinocerebellar Ataxia With Oculomotor Anomaly;   Spinocerebellar Ataxia With Epilepsy;   Spinocerebellar Ataxia With Axonal Neuropathy Type 2;   Spinocerebellar Ataxia Type 8;   Spinocerebellar Ataxia Type 7;   Spinocerebellar Ataxia Type 6;   Spinocerebellar Ataxia Type 5;   Spinocerebellar Ataxia Type 4;   Spinocerebellar Ataxia Type 37;   Spinocerebellar Ataxia Type 36;   Spinocerebellar Ataxia Type 35;   Spinocerebellar Ataxia Type 34;   Spinocerebellar Ataxia Type 32;   Spinocerebellar Ataxia Type 31;   Spinocerebellar Ataxia Type 30;   Spinocerebellar Ataxia Type 3;   Spinocerebellar Ataxia Type 29;   Spinocerebellar Ataxia Type 28;   Spinocerebellar Ataxia Type 27;   Spinocerebellar Ataxia Type 26;   Spinocerebellar Ataxia Type 25;   Spinocerebellar Ataxia Type 23;   Spinocerebellar Ataxia Type 22;   Spinocerebellar Ataxia Type 21;   Spinocerebellar Ataxia Type 20;   Spinocerebellar Ataxia Type 2;   Spinocerebellar Ataxia Type 19/22;   Spinocerebellar Ataxia Type 18;   Spinocerebellar Ataxia Type 17;   Spinocerebellar Ataxia Type 16;   Spinocerebellar Ataxia Type 15/16;   Spinocerebellar Ataxia Type 14;   Spinocerebellar Ataxia Type 13;   Spinocerebellar Ataxia Type 12;   Spinocerebellar Ataxia Type 11;   Spinocerebellar Ataxia Type 10;   Spinocerebellar Ataxia Type 1 With Axonal Neuropathy;   Spinocerebellar Ataxia Type 1;   Spinocerebellar Ataxia - Unknown;   Spinocerebellar Ataxia - Dysmorphism;   Non Progressive Epilepsy and/or Ataxia With Myoclonus as a Major Feature;   Spectrin-associated Autosomal Recessive Cerebellar Ataxia;   Spasticity-ataxia-gait Anomalies Syndrome;   Spastic Ataxia With Congenital Miosis;   Spastic Ataxia - Corneal Dystrophy;   Spastic Ataxia;   Rare Hereditary Ataxia;   Rare Ataxia;   Recessive Mitochondrial Ataxia Syndrome;   Progressive Epilepsy and/or Ataxia With Myoclonus as a Major Feature;   Posterior Column Ataxia - Retinitis Pigmentosa;   Post-Stroke Ataxia;   Post-Head Injury Ataxia;   Post Vaccination Ataxia;   Polyneuropathy - Hearing Loss - Ataxia - Retinitis Pigmentosa - Cataract;   Muscular Atrophy - Ataxia - Retinitis Pigmentosa - Diabetes Mellitus;   Non-progressive Cerebellar Ataxia With Intellectual Disability;   Non-hereditary Degenerative Ataxia;   Paroxysmal Dystonic Choreathetosis With Episodic Ataxia and Spasticity;   Olivopontocerebellar Atrophy - Deafness;   NARP Syndrome;   Myoclonus - Cerebellar Ataxia - Deafness;   Multiple System Atrophy, Parkinsonian Type;   Multiple System Atrophy, Cerebellar Type;   Multiple System Atrophy;   Maternally-inherited Leigh Syndrome;   Machado-Joseph Disease Type 3;   Machado-Joseph Disease Type 2;   Machado-Joseph Disease Type 1;   Lethal Ataxia With Deafness and Optic Atrophy;   Leigh Syndrome;   Leukoencephalopathy With Mild Cerebellar Ataxia and White Matter Edema;   Leukoencephalopathy - Ataxia - Hypodontia - Hypomyelination;   Leigh Syndrome With Nephrotic Syndrome;   Leigh Syndrome With Leukodystrophy;   Leigh Syndrome With Cardiomyopathy;   Late-onset Ataxia With Dementia;   Intellectual Disability-hyperkinetic Movement-truncal Ataxia Syndrome;   Infection or Post Infection Ataxia;   Infantile-onset Autosomal Recessive Nonprogressive Cerebellar Ataxia;   Infantile Onset Spinocerebellar Ataxia;   GAD Ataxia;   Hereditary Episodic Ataxia;   Gliadin/Gluten Ataxia;   Friedreich Ataxia;   Fragile X-associated Tremor/Ataxia Syndrome;   Familial Paroxysmal Ataxia;   Exposure to Medications Ataxia;   Episodic Ataxia With Slurred Speech;   Episodic Ataxia Unknown Type;   Episodic Ataxia Type 7;   Episodic Ataxia Type 6;   Episodic Ataxia Type 5;   Episodic Ataxia Type 4;   Episodic Ataxia Type 3;   Episodic Ataxia Type 1;   Epilepsy and/or Ataxia With Myoclonus as Major Feature;   Early-onset Spastic Ataxia-neuropathy Syndrome;   Early-onset Progressive Neurodegeneration - Blindness - Ataxia - Spasticity;   Early-onset Cerebellar Ataxia With Retained Tendon Reflexes;   Early-onset Ataxia With Dementia;   Childhood-onset Autosomal Recessive Slowly Progressive Spinocerebellar Ataxia;   Dilated Cardiomyopathy With Ataxia;   Cataract - Ataxia - Deafness;   Cerebellar Ataxia, Cayman Type;   Cerebellar Ataxia With Peripheral Neuropathy;   Cerebellar Ataxia - Hypogonadism;   Cerebellar Ataxia - Ectodermal Dysplasia;   Cerebellar Ataxia - Areflexia - Pes Cavus - Optic Atrophy - Sensorineural Hearing Loss;   Brain Tumor Ataxia;   Brachydactyly - Nystagmus - Cerebellar Ataxia;   Benign Paroxysmal Tonic Upgaze of Childhood With Ataxia;   Autosomal Recessive Syndromic Cerebellar Ataxia;   Autosomal Recessive Spastic Ataxia With Leukoencephalopathy;   Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay;   Autosomal Recessive Spastic Ataxia - Optic Atrophy - Dysarthria;   Autosomal Recessive Spastic Ataxia;   Autosomal Recessive Metabolic Cerebellar Ataxia;   Autosomal Dominant Spinocerebellar Ataxia Due to Repeat Expansions That do Not Encode Polyglutamine;   Autosomal Recessive Ataxia, Beauce Type;   Autosomal Recessive Ataxia Due to Ubiquinone Deficiency;   Autosomal Recessive Ataxia Due to PEX10 Deficiency;   Autosomal Recessive Degenerative and Progressive Cerebellar Ataxia;   Autosomal Recessive Congenital Cerebellar Ataxia Due to MGLUR1 Deficiency;   Autosomal Recessive Congenital Cerebellar Ataxia Due to GRID2 Deficiency;   Autosomal Recessive Congenital Cerebellar Ataxia;   Autosomal Recessive Cerebellar Ataxia-pyramidal Signs-nystagmus-oculomotor Apraxia Syndrome;   Autosomal Recessive Cerebellar Ataxia-epilepsy-intellectual Disability Syndrome Due to WWOX Deficiency;   Autosomal Recessive Cerebellar Ataxia-epilepsy-intellectual Disability Syndrome Due to TUD Deficiency;   Autosomal Recessive Cerebellar Ataxia-epilepsy-intellectual Disability Syndrome Due to KIAA0226 Deficiency;   Autosomal Recessive Cerebellar Ataxia-epilepsy-intellectual Disability Syndrome;   Autosomal Recessive Cerebellar Ataxia With Late-onset Spasticity;   Autosomal Recessive Cerebellar Ataxia Due to STUB1 Deficiency;   Autosomal Recessive Cerebellar Ataxia Due to a DNA Repair Defect;   Autosomal Recessive Cerebellar Ataxia - Saccadic Intrusion;   Autosomal Recessive Cerebellar Ataxia - Psychomotor Retardation;   Autosomal Recessive Cerebellar Ataxia - Blindness - Deafness;   Autosomal Recessive Cerebellar Ataxia;   Autosomal Dominant Spinocerebellar Ataxia Due to a Polyglutamine Anomaly;   Autosomal Dominant Spinocerebellar Ataxia Due to a Point Mutation;   Autosomal Dominant Spinocerebellar Ataxia Due to a Channelopathy;   Autosomal Dominant Spastic Ataxia Type 1;   Autosomal Dominant Spastic Ataxia;   Autosomal Dominant Optic Atrophy;   Ataxia-telangiectasia Variant;   Ataxia-telangiectasia;   Autosomal Dominant Cerebellar Ataxia, Deafness and Narcolepsy;   Autosomal Dominant Cerebellar Ataxia Type 4;   Autosomal Dominant Cerebellar Ataxia Type 3;   Autosomal Dominant Cerebellar Ataxia Type 2;   Autosomal Dominant Cerebellar Ataxia Type 1;   Autosomal Dominant Cerebellar Ataxia;   Ataxia-telangiectasia-like Disorder;   Ataxia-intellectual Disability-oculomotor Apraxia-cerebellar Cysts Syndrome;   Ataxia-deafness-intellectual Disability Syndrome;   Ataxia With Vitamin E Deficiency;   Ataxia With Dementia;   Ataxia Neuropathy Spectrum;   Ataxia - Tapetoretinal Degeneration;   Ataxia - Photosensitivity - Short Stature;   Ataxia - Pancytopenia;   Ataxia - Oculomotor Apraxia Type 1;   Ataxia - Hypogonadism - Choroidal Dystrophy;   Ataxia - Other;   Ataxia - Genetic Diagnosis - Unknown;   Acquired Ataxia;   Adult-onset Autosomal Recessive Cerebellar Ataxia;   Alcohol Related Ataxia;   Multiple Endocrine Neoplasia;   Multiple Endocrine Neoplasia Type II;   Multiple Endocrine Neoplasia Type 1;   Multiple Endocrine Neoplasia Type 2;   Multiple Endocrine Neoplasia, Type IV;   Multiple Endocrine Neoplasia, Type 3;   Multiple Endocrine Neoplasia (MEN) Syndrome;   Multiple Endocrine Neoplasia Type 2B;   Multiple Endocrine Neoplasia Type 2A;   Atypical Hemolytic Uremic Syndrome;   Atypical HUS;   Wiedemann-Steiner Syndrome;   Breast Implant-Associated Anaplastic Large Cell Lymphoma;   Autoimmune/Inflammatory Syndrome Induced by Adjuvants (ASIA);   Hemophagocytic Lymphohistiocytosis;   Behcet's Disease;   Alagille Syndrome;   Inclusion Body Myopathy With Early-onset Paget Disease and Frontotemporal Dementia (IBMPFD);   Lowe Syndrome;   Pitt Hopkins Syndrome;   1p36 Deletion Syndrome;   Jansen Type Metaphyseal Chondrodysplasia;   Cockayne Syndrome;   Chronic Recurrent Multifocal Osteomyelitis;   CRMO;   Malan Syndrome;   Hereditary Sensory and Autonomic Neuropathy Type Ie
    Intervention:  
    Sponsors:   Sanford Health;   National Ataxia Foundation;   International WAGR Syndrome Association;   4p- Support Group;   ML4 Foundation;   Cornelia de Lange Syndrome Foundation;   Stickler Involved People;   Kawasaki Disease Foundation;   Klippel-Feil Syndrome Alliance;   Klippel-Feil Syndrome Freedom;   Hyperacusis Research Limited;   Hypersomnia Foundation;   Kabuki Syndrome Network;   Kleine-Levin Syndrome Foundation;   Leiomyosarcoma Direct Research Foundation;   Marinesco-Sjogren Syndrome Support Group;   Mucolipidosis Type IV (ML4) Foundation;   People with Narcolepsy 4 People with Narcolepsy (PWN4PWN);   Soft Bones Incorporated;   American Multiple Endocrine Neoplasia Support;   Atypical Hemolytic Uremic Syndrome Foundation;   All Things Kabuki;   Wiedemann-Steiner Syndrome Foundation;   Breast Implant Victim Advocates;   PROS Foundation;   American Behcet's Disease Association
    Recruiting

  • Conditions:   Advanced Malignant Neoplasm;   Castleman Disease;   Digestive System Carcinoma;   Erdheim-Chester Disease;   Lip and Oral Cavity Carcinoma;   Lymphangioleiomyomatosis;   Malignant Endocrine Neoplasm;   Malignant Female Reproductive System Neoplasm;   Malignant Male Reproductive System Neoplasm;   Malignant Neoplasm;   Malignant Respiratory Tract Neoplasm;   Malignant Thoracic Neoplasm;   Malignant Urinary System Neoplasm;   Mesothelial Neoplasm;   Metastatic Malignant Neoplasm;   Metastatic Urothelial Carcinoma;   Neurofibromatosis Type 2;   Recurrent Adult Soft Tissue Sarcoma;   Recurrent Breast Carcinoma;   Recurrent Childhood Soft Tissue Sarcoma;   Recurrent Digestive System Carcinoma;   Recurrent Female Reproductive System Carcinoma;   Recurrent Male Reproductive System Carcinoma;   Recurrent Malignant Neoplasm;   Recurrent Pharyngeal Carcinoma;   Recurrent Thyroid Gland Carcinoma;   Refractory Malignant Neoplasm;   Soft Tissue Neoplasm;   Stage III Breast Cancer AJCC v7;   Stage III Pharyngeal Cancer;   Stage IIIA Breast Cancer AJCC v7;   Stage IIIB Breast Cancer AJCC v7;   Stage IIIC Breast Cancer AJCC v7;   Stage IV Breast Cancer AJCC v6 and v7;   Stage IV Pharyngeal Cancer;   Stage IVA Pharyngeal Cancer;   Stage IVB Pharyngeal Cancer;   Stage IVC Pharyngeal Cancer;   Thyroid Gland Neoplasm
    Interventions:   Biological: Bevacizumab;   Biological: Cetuximab;   Other: Laboratory Biomarker Analysis;   Other: Pharmacological Study;   Drug: Temsirolimus;   Drug: Valproic Acid
    Sponsors:   M.D. Anderson Cancer Center;   National Cancer Institute (NCI)
    Recruiting

  • Conditions:   Usher Syndrome;   Retinitis Pigmentosa
    Intervention:   Genetic: SAR421869
    Sponsor:   Sanofi
    Recruiting

  • Conditions:   Spinal Cord Disease;   Intracranial Central Nervous System Disorder;   Neurologic Disorders;   Brain Neoplasms
    Intervention:  
    Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
    Recruiting