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- Conditions: Cataract; Age Related Macular Degeneration; Pseudophakia; Macular Disease; Diabetic Retinopathy; Retinal Disease
Intervention: Diagnostic Test: polarization sensitivity
Sponsors: South Warwickshire NHS Foundation Trust; Aston University
Recruiting - Conditions: Leber Congenital Amaurosis (LCA); Eye Diseases; Eye Diseases, Hereditary; Retinal Diseases
Intervention: Biological: AAV OPTIRPE65
Sponsors: MeiraGTx UK II Ltd; Syne Qua Non Limited
Recruiting - Condition: Open Angle Glaucoma
Interventions: Device: Direct Selective Trabeculoplasty; Device: Selective Trabeculoplasty
Sponsors: Belkin Laser Ltd.; European Commission; Universita degli Studi di Genova; Queen's University, Belfast; Moorfields Eye Hospital NHS Foundation Trust
Recruiting - Condition: Diabetes Mellitus, Type 2
Interventions: Drug: Semaglutide; Drug: Placebo (semaglutide)
Sponsor: Novo Nordisk A/S
Recruiting - Condition: Diabetic Retinopathy
Interventions: Drug: BI 1467335; Drug: Placebo
Sponsor: Boehringer Ingelheim
Recruiting - Conditions: Glaucoma, Suspect; Glaucoma
Interventions: Diagnostic Test: Humphrey Visual Field Test; Diagnostic Test: Optical Coherence Tomography (OCT) Scan; Diagnostic Test: Smart Perimetry - Henson 9000
Sponsors: Manchester University NHS Foundation Trust; University of Manchester; Columbia University
Not yet recruiting - Condition: Ametropia
Interventions: Device: comfilcon A asphere; Device: Spectacles
Sponsor: Coopervision, Inc.
Recruiting - Condition: Ametropia
Interventions: Device: somofilcon A; Device: nelfilcon A
Sponsor: Coopervision, Inc.
Recruiting - Condition: Refractive Errors
Intervention: Device: Spectacles
Sponsors: Queen's University, Belfast; Zhongshan Ophthalmic Center, Sun Yat-sen University; Stanford University; New England College of Optometry; Clearly; Ningxia Medical University
Not yet recruiting - Condition: Aphakia
Intervention: Device: Softec HP1 Intraocular Lens
Sponsor: Lenstec Incorporated
Not yet recruiting - Condition: Keratoconus
Intervention: Procedure: Customised CXL
Sponsor: Moorfields Eye Hospital NHS Foundation Trust
Recruiting - Condition: Glaucoma
Intervention: Drug: Sildenafil 100mg
Sponsor: Imperial College London
Recruiting - Condition: Keratoconus
Intervention: Procedure: Corneal Cross-linking
Sponsor: University of Plymouth
Recruiting - Condition: Glaucoma
Intervention:
Sponsor: Portsmouth Hospitals NHS Trust
Recruiting - Condition: Cataract
Intervention: Device: Binocular-OCT
Sponsor: Moorfields Eye Hospital NHS Foundation Trust
Recruiting - Condition: Glaucoma
Intervention: Other: sodium hyaluronate eyedrops
Sponsor: Imperial College London
Recruiting - Conditions: Myopia; Refractive Errors
Interventions: Procedure: Small incision lenticule extraction; Drug: Tobramycin and dexamethasone; Drug: Ofloxacin; Drug: Proxymetacaine 0.5%; Drug: Oxybuprocaine 0.4%
Sponsor: London Vision Clinic
Recruiting - Condition: Cataract
Intervention: Device: EyeCee One intraocular lens
Sponsor: University of Plymouth
Recruiting - Condition: Corneal Astigmatism
Interventions: Procedure: Trans-epithelial PTK; Device: EpiMaster Application Software
Sponsors: London Vision Clinic; Carl Zeiss Meditec AG; Optana GmbH
Recruiting - Condition: Myopia
Interventions: Device: comfilcon A; Device: somofilcon A; Device: stenfilcon A
Sponsor: Coopervision, Inc.
Recruiting - Condition: Cataract
Interventions: Device: T-flex Aspheric Toric IOL; Device: AT TORBI toric IOL
Sponsors: University of Plymouth; BMI Southend Hospital
Recruiting - Condition: Non-syndromic Retinitis Pigmentosa
Intervention: Combination Product: Gene therapy: GS030-DP AND Medical device: GS030-MD
Sponsor: GenSight Biologics
Recruiting - Conditions: Keratoconus; Fuchs Dystrophy; Corneal Disease
Interventions: Procedure: Femtosecond Laser; Procedure: Trephine blade
Sponsor: University of Southampton
Recruiting - Condition: AMD
Interventions: Diagnostic Test: OCT; Diagnostic Test: Visual Acuity
Sponsors: Moorfields Eye Hospital NHS Foundation Trust; National Institute for Health Research, United Kingdom; Newcastle University; Cardiff University; City, University of London; King's College London; Manchester University NHS Foundation Trust; University Hospitals Bristol NHS Foundation Trust; York Teaching Hospitals NHS Foundation Trust; Leeds Teaching Hospital NHS Foundation Trust; Bradford Teaching Hospitals NHS Foundation Trust; University College, London
Not yet recruiting - Condition: Age Related Macular Degeneration
Interventions: Drug: Ranibizumab; Drug: Aflibercept
Sponsors: King's College Hospital NHS Trust; King's College London
Recruiting - Condition: Graves' Disease
Intervention: Drug: K1-70 intramuscular or K1-70 intravenous
Sponsor: AV7 Limited
Recruiting - Condition: Myopia
Interventions: Drug: Atropine Sulfate; Other: Placebo
Sponsor: Belfast Health and Social Care Trust
Recruiting - Condition: Wet Age-related Macular Degeneration
Intervention: Drug: Aflibercept (Eylea, BAY86-5321)
Sponsor: Bayer
Recruiting - Condition: Non-infectious Uveitis
Intervention: Biological: pEYS606
Sponsor: EYEVENSYS S.A.S.
Recruiting - Condition: Ocular Surface Disease
Intervention: Other: Autologous blood applied to dry eye
Sponsors: NHS Lanarkshire; Chief Scientist Office of the Scottish Government; NHS Research Scotland
Recruiting - Conditions: Pseudophakia; Accomodation; Aberration, Corneal Wavefront
Intervention:
Sponsors: Brighton and Sussex University Hospitals NHS Trust; King's College London; European Society of Cataract and Refractive Surgeons
Recruiting - Conditions: Epiretinal Membrane; Retinal Hemorrhage
Intervention: Device: Robot assisted surgery
Sponsor: University of Oxford
Recruiting - Conditions: Dry Age-related Macular Degeneration; Macular Degeneration; Retinal Disease; Eye Diseases; Retinal Degeneration; Geographic Atrophy; Macular Atrophy
Intervention: Biological: GT005
Sponsor: Gyroscope Therapeutics
Recruiting - Condition: Age- Related Macular Degeneration
Intervention: Drug: Minocycline
Sponsor: National Eye Institute (NEI)
Recruiting - Conditions: Leber Congenital Amaurosis 10; Blindness; Leber Congenital Amaurosis; Vision Disorders; Sensation Disorders; Neurologic Manifestations; Eye Diseases; Eye Diseases, Hereditary; Eye Disorders Congenital; Retinal Disease
Interventions: Drug: QR-110; Other: Sham
Sponsor: ProQR Therapeutics
Recruiting - Condition: Vision, Low
Interventions: Device: MED; Other: Buddy
Sponsors: University of Manchester; City, University of London; Schepens Eye Research Institute
Recruiting - Conditions: LGMD2I; LGMDR9; Limb Girdle Muscular Dystrophy; Congenital Muscular Dystrophy; Muscle-Eye-Brain Disease; Walker-Warburg Syndrome; FKRP Gene Mutation
Intervention: Other: Patient Registry
Sponsor: Newcastle University
Recruiting - Conditions: Pseudophakic Cystoid Macular Oedema; Epiretinal Membrane
Intervention: Drug: topical (eye drop) anti-inflammatories
Sponsor: Portsmouth Hospitals NHS Trust
Recruiting - Condition: Atopic Keratoconjunctivitis (AKC)
Interventions: Drug: rVA576; Other: Placebo
Sponsor: AKARI Therapeutics
Recruiting - Condition: Eye Injury Trauma
Intervention: Drug: Triamcinolone Acetonide
Sponsor: Moorfields Eye Hospital NHS Foundation Trust
Recruiting - Conditions: Accidental Fall; Visual Impairment; Fall
Interventions: Other: 5 day falls prevention training; Other: Home exercise programme; Other: Environmental Assessment
Sponsor: Blind Veterans UK
Not yet recruiting - Condition: Macular Degeneration
Intervention: Drug: BI 754132
Sponsor: Boehringer Ingelheim
Recruiting - Condition: Wet Macular Degeneration
Interventions: Drug: Faricimab; Drug: Aflibercept; Drug: Sham Procedure
Sponsor: Hoffmann-La Roche
Recruiting - Conditions: AMD; Diabetic Retinopathy; Retinal Degeneration; Retinal Dystrophies
Intervention: Device: Combined Coaxial Optical Coherence Tomography
Sponsor: Moorfields Eye Hospital NHS Foundation Trust
Recruiting - Condition: Wolfram Syndrome
Interventions: Drug: Sodium Valproate 200Mg E/C Tablet; Drug: Sodium Valproate matched placebo
Sponsor: University of Birmingham
Recruiting - Condition: Achromatopsia
Intervention: Biological: either AAV - CNGB3 or AAV - CNGA3
Sponsors: MeiraGTx UK II Ltd; Syne Qua Non Limited; EMAS Pharma
Recruiting - Conditions: Uveitis; JIA
Interventions: Biological: Adalimumab; Other: Placebo
Sponsors: Nisha Acharya; Children's Hospital of Philadelphia; Children's Hospital Medical Center, Cincinnati; Children's Mercy Hospital Kansas City; National Eye Institute (NEI); Great Ormond Street Hospital for Children NHS Foundation Trust; University Hospitals Bristol NHS Foundation Trust; Alder Hey Children's NHS Foundation Trust; Johns Hopkins University; Children's Hospital Los Angeles; Seattle Children's Hospital; Newcastle-upon-Tyne Hospitals NHS Trust; University Hospital Southampton NHS Foundation Trust; Sheffield Children's NHS Foundation Trust; The Royal Children's Hospital
Not yet recruiting - Condition: Uveitis
Interventions: Biological: Adalimumab (ADA); Drug: Conventional immunosuppression (CON)
Sponsor: JHSPH Center for Clinical Trials
Recruiting - Condition: Uveitis
Interventions: Drug: Baricitinib; Drug: Adalimumab
Sponsor: Eli Lilly and Company
Not yet recruiting - Condition: Noninfectious Uveitis
Interventions: Drug: Filgotinib; Drug: Placebo to match filgotinib; Drug: Prednisone
Sponsor: Gilead Sciences
Recruiting - Condition: Glaucoma, Angle-Closure
Intervention: Device: XEN45
Sponsor: Allergan
Recruiting - Condition: Open Angle Glaucoma and Cataract
Intervention: Drug: Prostaglandins
Sponsor: Emily Woodhouse
Recruiting - Conditions: Dry Age-related Macular Degeneration; Macular Degeneration; Retinal Disease; Retinal Degeneration; Geographic Atrophy; Macular Atrophy
Intervention:
Sponsor: Gyroscope Therapeutics
Recruiting - Condition: Glaucoma
Intervention:
Sponsor: Allergan
Recruiting - Condition: Leber Hereditary Optic Neuropathy
Intervention: Other: Patient-reported outcomes (PROs)
Sponsor: GenSight Biologics
Recruiting - Condition: Amblyopia
Intervention: Diagnostic Test: Visual acuity tests
Sponsor: Anglia Ruskin University
Recruiting - Condition: Myopia
Interventions: Drug: NVK-002 Concentration 1; Drug: NVK-002 Concentration 2; Drug: Placebo
Sponsors: Nevakar, LLC; Syneos Health
Recruiting - Condition: Leber Hereditary Optic Neuropathy (Optic, Atrophy, Hereditary, Leber)
Interventions: Genetic: GS010; Other: Sham Intravitreal Injection
Sponsor: GenSight Biologics
Recruiting - Natural History Study of Patients With Leber Congenital Amaurosis Associated With Mutations in RPE65Condition: Leber Congenital Amaurosis
Intervention:
Sponsor: MeiraGTx UK II Ltd
Recruiting - Condition: Achromatopsia
Intervention: Biological: AAV- CNGA3
Sponsor: MeiraGTx UK II Ltd
Recruiting - Conditions: Hyperopia; Amblyopia; Anisohyperopia
Interventions: Device: Multifocal contact lenses; Device: Single vision contact lenses
Sponsors: Aston University; College of Optometrists
Recruiting - Conditions: Mitochondrial Diseases; Mitochondrial Myopathies; Progressive External Ophthalmoplegia; Progressive Ophthalmoplegia; Progressive; Ophthalmoplegia, External; Mitochondria DNA Deletion; MELAS; Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Episodes; Mitochondrial Encephalopathy, Lactic Acidosis and Stroke-Like Episodes (MELAS Syndrome)
Intervention: Dietary Supplement: Nicotinamide Riboside
Sponsors: Cambridge University Hospitals NHS Foundation Trust; University of Cambridge; MRC Mitochondrial Biology Unit
Recruiting - Conditions: Vision Disorders; Reading Disabilities
Interventions: Device: Precision tinted lenses; Device: Non-beneficial tinted lenses
Sponsor: City, University of London
Recruiting - Conditions: Neurofibromatosis Type 1; Plexiform Neurofibroma; Optic Nerve Glioma
Intervention: Drug: Selumetinib
Sponsors: Great Ormond Street Hospital for Children NHS Foundation Trust; AstraZeneca
Not yet recruiting - Condition: X-Linked Retinitis Pigmentosa
Intervention: Genetic: AAV-RPGR
Sponsors: MeiraGTx UK II Ltd; Syne Qua Non Limited; Bionical-Emas Pharma Ltd
Recruiting - Conditions: Open Angle Glaucoma; Ocular Hypertension
Interventions: Drug: Netarsudil/Latanoprost 0.02%/0.005%; Drug: GANFORT®
Sponsor: Aerie Pharmaceuticals
Recruiting - Conditions: Glaucoma, Open-Angle; Ocular Hypertension
Interventions: Drug: Bimatoprost SR; Drug: Sham Bimatoprost SR; Procedure: Selective Laser Trabeculoplasty; Procedure: Sham Selective Laser Trabeculoplasty
Sponsor: Allergan
Recruiting - Conditions: Open-Angle Glaucoma; Ocular Hypertension
Intervention: Drug: Bimatoprost SR
Sponsor: Allergan
Recruiting - Condition: Age Related Macular Degeneration (AMD)
Intervention: Other: No intervention
Sponsors: Frank G. Holz; Bayer; Moorfields Eye Hospital NHS Foundation Trust; Novartis Pharmaceuticals; Association for Innovation and Biomedical Research on Light and Image; City, University of London; European Clinical Research Infrastructure Network; La Fondation Voir et Entendre; Hoffmann-La Roche; Radboud University; University of Sheffield; University College, London; Carl Zeiss Meditec AG; Innovative Medicines Initiative
Recruiting - Condition: Stargardt Disease
Interventions: Drug: Emixustat; Drug: Placebo
Sponsor: Acucela Inc.
Recruiting - Conditions: Stroke; CVA (Cerebrovascular Accident); CVA; Sequelae; Stroke, Ischemic; Stroke Hemorrhagic; Hemianopia; Hemiplegia; Hemiparesis; Aphasia; Cerebral Infarction; Intracerebral Hemorrhage; Anxiety; Depression; Dysphagia; Dysarthria; Hemispatial Neglect; Mild Cognitive Impairment
Intervention:
Sponsor: Aneurin Bevan University Health Board
Recruiting - Condition: Dry Age-related Macular Degeneration
Interventions: Device: Valeda PBM treatment; Device: Valeda Sham treatment
Sponsor: LumiThera, Inc.
Recruiting - Condition: Diabetic Macular Edema
Interventions: Procedure: Diode 577 nm subthreshold micropulse laser; Procedure: Standard threshold laser (532 nm laser)
Sponsors: Belfast Health and Social Care Trust; Northern Ireland Clinical Trials Unit
Recruiting - Condition: Retinopathy of Prematurity (ROP)
Interventions: Drug: Eylea (Aflibercept, BAY86-5321); Procedure: Laser photocoagulation
Sponsor: Bayer
Not yet recruiting - Condition: Diabetic Macular Edema
Interventions: Drug: Aflibercept; Drug: Faricimab; Drug: Sham Procedure
Sponsor: Hoffmann-La Roche
Recruiting - Condition: Choroideremia
Intervention:
Sponsor: NightstaRx Ltd
Recruiting - Condition: X-Linked Retinitis Pigmentosa
Intervention: Biological: AAV8-RPGR
Sponsor: NightstaRx Ltd
Recruiting - Conditions: Health; Hypertension; Chronic Kidney Disease
Intervention:
Sponsor: University of Edinburgh
Recruiting - Condition: Choroideremia
Intervention: Genetic: AAV2-REP1
Sponsor: NightstaRx Ltd
Recruiting - Conditions: Pro-opiomelanocortin (POMC) Deficiency Obesity (Heterozygous or Epigenetic); Leptin Receptor Deficiency Obesity; Bardet-Biedl Syndrome; Alstrom Syndrome; Smith-Magenis Syndrome
Intervention: Drug: Setmelanotide
Sponsor: Rhythm Pharmaceuticals, Inc.
Recruiting - Conditions: Uveitis; Macular Edema
Interventions: Drug: Dexamethasone intravitreal implant 0.7 mg; Drug: Intravitreal Methotrexate 400 µg; Drug: Intravitreal Ranibizumab 0.5 mg
Sponsors: JHSPH Center for Clinical Trials; National Eye Institute (NEI)
Recruiting - Condition: Diabetic Retinopathy
Interventions: Drug: Fenofibrate 145 mg; Drug: Placebo Oral Tablet
Sponsors: University of Oxford; National Institute for Health Research, United Kingdom; University of Glasgow; University of Aberdeen; University of Dundee; University of Edinburgh; NHS Scotland Diabetic Retinopathy Screening Collaborative
Recruiting - Condition: Retinopathy of Prematurity (ROP)
Interventions: Drug: Eylea (Aflibercept, BAY86-5321); Procedure: Laser photocoagulation
Sponsor: Bayer
Not yet recruiting - Conditions: Guillain-Barré Syndrome; Miller Fisher Syndrome
Intervention:
Sponsor: Erasmus Medical Center
Recruiting - Condition: Diabetic Macular Edema
Interventions: Drug: Brolucizumab; Drug: Aflibercept
Sponsor: Novartis Pharmaceuticals
Recruiting - Condition: Primary Sjogren's Syndrome
Interventions: Biological: VAY736; Other: Placebo
Sponsor: Novartis Pharmaceuticals
Recruiting - Condition: Uveal Melanoma
Interventions: Biological: IMCgp100; Drug: Dacarbazine; Biological: Ipilimumab; Biological: Pembrolizumab
Sponsor: Immunocore Ltd
Recruiting - Conditions: Adenovirus; Anesthesia; Anxiety; Anxiolysis; Autism; Autistic Disorder; Bacterial Meningitis; Bacterial Septicemia; Benzodiazepine; Bipolar Disorder; Bone and Joint Infections; Central Nervous System Infections; Convulsions; Cytomegalovirus Retinitis; Early-onset Schizophrenia Spectrum Disorders; Epilepsy; General Anesthesia; Gynecologic Infections; Herpes Simplex Virus; Infantile Hemangioma; Infection; Inflammation; Inflammatory Conditions; Intra-abdominal Infections; Lower Respiratory Tract Infections; Migraines; Pain; Pneumonia; Schizophrenia; Sedation; Seizures; Skeletal Muscle Spasms; Skin and Skin-structure Infections; Treatment-resistant Schizophrenia; Urinary Tract Infections; Withdrawal; Sepsis; Gram-negative Infection; Bradycardia; Cardiac Arrest; Cardiac Arrhythmia; Staphylococcal Infections; Nosocomial Pneumonia; Neuromuscular Blockade; Methicillin Resistant Staphylococcus Aureus; Endocarditis; Neutropenia; Headache; Fibrinolytic Bleeding; Pulmonary Arterial Hypertension; CMV Retinitis; Hypertension; Chronic Kidney Diseases; Hyperaldosteronism; Hypokalemia; Heart Failure; Hemophilia; Heavy Menstrual Bleeding; Insomnia
Intervention: Drug: The POPS study is collecting PK data on children prescribed the following drugs of interest per standard of care:
Sponsors: Daniel Benjamin; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD); The Emmes Company, LLC
Recruiting - Condition: Central Retinal Vein Occlusion
Interventions: Drug: Brolucizumab 6 mg; Drug: Aflibercept 2 mg; Other: Sham injection
Sponsor: Novartis Pharmaceuticals
Recruiting - Conditions: Opsoclonus Myoclonus Syndrome; Neuroblastoma
Interventions: Drug: Dexamethasone acetate; Drug: dexamethasone and cyclophosphamide; Drug: dexamethasone and rituximab
Sponsor: Institut Curie
Recruiting - Condition: Melanoma, Ocular
Intervention: Combination Product: Melphalan/HDS
Sponsors: Delcath Systems Inc.; IQVIA Biotech
Recruiting
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