Acetylcysteine Research Studies

Condition:   Biliary Atresia
Intervention:   Drug: N-Acetyl cysteine
Sponsor:   Baylor College of Medicine
Recruiting

Condition:   Healthy
Intervention:   Drug: OP-101
Sponsor:   Orpheris, Inc.
Recruiting

Condition:   Mild Cognitive Impairment
Intervention:   Dietary Supplement: N- acetylcysteine plus Glycine v Placebo (alanine)
Sponsors:   Baylor College of Medicine;   Nantz National Alzheimer's Center, Methodist Hospital, Houston, TX
Recruiting

Condition:   Acute Respiratory Distress Syndrome
Intervention:   Drug: N-acetyl cysteine
Sponsor:   Palmetto Health
Recruiting

Conditions:   Diabetes Mellitus;   Critical Limb Ischemia;   Lower Limb Amputation Knee;   Peripheral Arterial Disease
Interventions:   Drug: Active Arm N-acetyl cysteine (NAC);   Drug: Placebo Arm
Sponsor:   Washington University School of Medicine
Recruiting

Condition:   Chronic Traumatic Brain Injury
Interventions:   Other: Anti-inflammatory Diet;   Dietary Supplement: N-acetyl Cysteine
Sponsor:   Thomas Jefferson University
Recruiting

Conditions:   Alcohol Drinking;   Control
Interventions:   Drug: N-Acetylcysteine;   Drug: Placebo Oral Capsule
Sponsors:   Medical University of South Carolina;   National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Recruiting

Condition:   Alcohol Use Disorder
Interventions:   Drug: Alcohol;   Drug: Placebos;   Drug: N-acetyl cysteine
Sponsors:   William Stoops;   National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Recruiting

Conditions:   Alcohol Use Disorder;   Bipolar Disorder
Interventions:   Drug: N-Acetylcysteine;   Drug: Gabapentin;   Drug: Placebo Oral Tablet
Sponsors:   Medical University of South Carolina;   National Institutes of Health (NIH);   National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Recruiting

Condition:   Marijuana Abuse
Intervention:   Drug: N-acetyl cysteine
Sponsor:   Wayne State University
Recruiting

Condition:   Alcoholism
Interventions:   Drug: Topiramate and N-Acetyl Cysteine;   Drug: Topiramate and Placebo
Sponsor:   Nassima Ait-Daoud Tiouririne
Recruiting

Condition:   Retinitis Pigmentosa
Intervention:   Drug: N-Acetyl Cysteine (NAC)
Sponsor:   Johns Hopkins University
Recruiting

Condition:   Cannabis Use Disorder
Interventions:   Drug: N-acetyl cysteine;   Drug: Placebo oral capsule
Sponsor:   Medical University of South Carolina
Recruiting

Condition:   Multiple Sclerosis
Intervention:   Dietary Supplement: N-acetyl Cysteine
Sponsor:   Thomas Jefferson University
Recruiting

Condition:   Autism Spectrum Disorder
Interventions:   Drug: N-acetylcysteine;   Drug: Placebo
Sponsor:   Emory University
Not yet recruiting

Condition:   Cocaine Dependence
Interventions:   Dietary Supplement: N-acetylcysteine;   Other: Placebo
Sponsor:   Yale University
Recruiting

Conditions:   Post Traumatic Stress Disorder (PTSD);   Addiction;   Alcohol Abuse
Interventions:   Drug: N-Acetylcysteine (NAC) Treatment;   Behavioral: Cognitive Behavioral Therapy;   Drug: Placebo Oral Capsule
Sponsors:   Medical University of South Carolina;   National Institute on Alcohol Abuse and Alcoholism (NIAAA);   National Institutes of Health (NIH)
Recruiting

Conditions:   Posttraumatic Stress Disorder (PTSD);   Alcohol Use Disorder (AUD);   Substance Use Disorder (SUD)
Interventions:   Drug: N-acetylcysteine;   Drug: Placebo;   Behavioral: Cognitive behavioral therapy
Sponsors:   Medical University of South Carolina;   United States Department of Defense;   Institute for Translational Neuroscience
Recruiting

Condition:   Depression
Intervention:   Drug: N-acetyl cysteine
Sponsor:   University of Cincinnati
Recruiting

Conditions:   Progressive Multiple Sclerosis;   Fatigue
Interventions:   Drug: N-acetyl cysteine;   Drug: Placebo
Sponsor:   University of California, San Francisco
Recruiting

Conditions:   Traumatic Brain Injury (TBI);   Hazardous and Harmful Alcohol Use
Interventions:   Behavioral: Medical Management Counseling;   Drug: N-acetylcysteine;   Drug: Placebo
Sponsors:   University of California, San Francisco;   United States Department of Defense;   Northern California Institute of Research and Education;   San Francisco Veterans Affairs Medical Center;   Institute for Translational Neuroscience
Recruiting

Conditions:   Nicotine Dependence;   Smoking
Interventions:   Drug: N-acetylcysteine (NAC);   Other: Placebo
Sponsors:   Medical University of South Carolina;   National Institute on Drug Abuse (NIDA)
Recruiting

Conditions:   Thoracic Surgery;   Atrial Fibrillation in High Risk Patients
Interventions:   Drug: Amiodarone;   Drug: N-Acetylcysteine;   Drug: Placebo
Sponsors:   Memorial Sloan Kettering Cancer Center;   Washington University School of Medicine;   The Cleveland Clinic;   Vanderbilt University School of Medicine
Recruiting

Conditions:   Bipolar Disorder;   Bipolar Depression
Interventions:   Dietary Supplement: N-acetylcysteine;   Drug: Minocycline;   Other: Placebo
Sponsor:   Massachusetts General Hospital
Recruiting

Condition:   Nicotine Dependence, Cigarettes
Interventions:   Drug: Varenicline (VRN);   Drug: N-Acetylcysteine (NAC);   Drug: Placebo
Sponsor:   Medical University of South Carolina
Recruiting

Condition:   Gaucher Disease Type 1
Intervention:   Drug: N-acetylcysteine
Sponsors:   University of Minnesota - Clinical and Translational Science Institute;   Rare Diseases Clinical Research Network;   National Center for Advancing Translational Science (NCATS);   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK);   National Institute of Neurological Disorders and Stroke (NINDS);   Lysosomal Disease Network
Recruiting

Condition:   Bipolar Disorder
Intervention:   Drug: Open-label Treatment with N-Acetylcysteine
Sponsor:   Massachusetts General Hospital
Recruiting

Conditions:   Aging;   Erythrocyte Glutathione Deficiency;   Muscle Weakness
Intervention:   Dietary Supplement: Cysteine (as n-acetylcysteine) and Glycine
Sponsor:   Baylor College of Medicine
Recruiting

Conditions:   Mucopolysaccharidosis Disorders;   Hurler Syndrome;   Hunter Syndrome;   Maroteaux Lamy Syndrome;   Sly Syndrome;   Alpha-Mannosidosis;   Fucosidosis;   Aspartylglucosaminuria;   Glycoprotein Metabolic Disorders;   Sphingolipidoses;   Recessive Leukodystrophies;   Globoid Cell Leukodystrophy;   Metachromatic Leukodystrophy;   Niemann-Pick B;   Niemann-Pick C Subtype 2;   Sphingomyelin Deficiency;   Peroxisomal Disorders;   Adrenoleukodystrophy With Cerebral Involvement;   Zellweger Syndrome;   Neonatal Adrenoleukodystrophy;   Infantile Refsum Disease;   Acyl-CoA Oxidase Deficiency;   D-Bifunctional Enzyme Deficiency;   Multifunctional Enzyme Deficiency;   Alpha-methylacyl-CoA Racmase Deficiency;   Mitochondrial Neurogastrointestingal Encephalopathy;   Severe Osteopetrosis;   Hereditary Leukoencephalopathy With Axonal Spheroids (HDLS; CSF1R Mutation);   Inherited Metabolic Disorders
Interventions:   Biological: Stem Cell Transplantation;   Drug: IMD Preparative Regimen;   Drug: Osteopetrosis Only Preparative Regimen;   Drug: Osteopetrosis Haploidentical Only Preparative Regimen;   Drug: cALD SR-A (Standard-Risk, Regimen A);   Drug: cALD SR-B (Standard-Risk, Regimen B);   Drug: cALD HR-D (High-Risk, Regimen C);   Drug: cALD HR-D (High-Risk, Regimen D)
Sponsor:   Masonic Cancer Center, University of Minnesota
Recruiting

Condition:   Cocaine Dependence
Interventions:   Drug: N-acetyl cysteine;   Drug: riluzole;   Drug: pentoxifylline;   Drug: 13C MRS;   Behavioral: Continued abstinence
Sponsor:   Yale University
Recruiting

Conditions:   Neuroectodermal Tumors, Primitive;   Liver Neoplasms;   Neoplasms, Germ Cell and Embryonal;   Osteosarcoma;   Other Childhood Cancers Using Cisplatin-based Regimens
Intervention:   Drug: N-Acetylcysteine
Sponsor:   Children's Hospital Los Angeles
Recruiting

Condition:   Aging
Intervention:   Dietary Supplement: Glycine, cysteine (as n-acetylcysteine), alanine
Sponsors:   Rajagopal V Sekhar;   National Institute on Aging (NIA)
Recruiting