Find Research Studies in Michigan for Allergies

Penicillin Allergy in Shfayim Clinic

Condition: Penicillin Allergy
Intervention: Drug: Amoxicillin
Sponsor: Clalit Health Services
Not yet recruiting
Impact of Sleep Extension in Adolescents

Conditions: Insulin Sensitivity; Sleep; Dietary Habits
Intervention: Behavioral: Sleep Extension
Sponsor: University of Colorado, Denver
Recruiting
Citalopram for Reflux Hypersensitivity and Functional Heartburn

Condition: GERD
Intervention: Drug: Citalopram 20mg
Sponsor: Universitaire Ziekenhuizen Leuven
Not yet recruiting
Repeatability and Reproducibility of Skin Test Endpoint Titration

Condition: Allergic Reaction
Intervention: Procedure: Skin test endpoint titration
Sponsor: University of Saskatchewan
Not yet recruiting
Metabolic and Muscular Adaptations During Inactivity in 3 Days of Bed-rest

Conditions: Muscle Atrophy; Insulin Sensitivity
Interventions: Other: Bed Rest; Other: Reconditioning
Sponsor: University of Nottingham
Recruiting
Assessment and Prediction of Cetuximab-Induced Hypersensitivity Reactions Using Cetuximab Specific IgE Detection

Conditions: Tumor Disease Including Colorectal Cancer; Head & Neck Squamous Cell Carcinoma
Intervention:
Sponsor: Yonsei University
Recruiting
Proof of Concept ELectro-Stimulation of Muscles to resolVe Insulin Resistance in NASH

Conditions: NASH - Nonalcoholic Steatohepatitis; Insulin Sensitivity
Intervention: Device: Electro-muscular stimulation using NeuroTrac MyoPlus 2/4
Sponsor: NHS Tayside
Recruiting
Urodynamics and Clinical Factors That Are Associated With Bladder Over-sensitivity

Conditions: Overactive Bladder Syndrome; Bladder Outlet Obstruction; Benign Prostate Enlargement; Stress Incontinence (Female) (Male); Bladder Disease
Intervention: Other: IPSS questionnaire
Sponsor: Assaf-Harofeh Medical Center
Recruiting
Culturally Sensitive Pain Education Program for Turkish Patients

Condition: Chronic Low Back Pain
Interventions: Behavioral: Culturally sensitive pain education; Behavioral: Standard pain education program
Sponsor: Hacettepe University
Not yet recruiting
The Interaction Between NGF-induced Muscle Sensitivity and Acute Exercise-induced Ischemia

Conditions: Muscle Hypersensitivity; Pain Response; Healthy Subjects
Intervention: Drug: NGF/Isotonic saline
Sponsor: Aalborg University
Recruiting
Fluciclovine-PET/CT for Bone Metastases From Prostate Adenocarcinoma

Condition: Prostate Adenocarcinoma
Intervention: Diagnostic Test: F-18 fluciclovine-PET/CT scan
Sponsors: University of Arizona; Blue Earth Diagnostics, Ltd; Banner University Medical Center
Not yet recruiting
Prevention of Allergic Diseases in Infants

Condition: Atopic Diseases
Interventions: Other: Hydrolyzed Formula; Other: Control formula
Sponsor: HiPP GmbH & Co. Vertrieb KG
Not yet recruiting
The Application of Microcurrent in Athletes

Condition: Training Group, Sensitivity
Intervention: Device: Microcurrent
Sponsors: University of Greenwich; Arc Family
Recruiting
Efficacy of the "Milk Ladder" Intervention in the Development of Tolerance and the Recognition of B Cell Epitopes in Babies Who Are Allergic to Cow's Milk Proteins

Condition: IgE-mediated Milk Allergy
Intervention: Other: Milk
Sponsor: Hospital San Carlos, Madrid
Not yet recruiting
A Study to Assess Primarily the Tolerability and Safety of SAR439794 After Repeated Sublingual Daily Administration in Peanut Allergic Adult Patients

Condition: Food Allergy
Interventions: Drug: Glucopyranosyl Lipid A (GLA); Drug: Sublingual Immuno Therapy (SLIT) Peanut Extract (PE); Drug: Placebo for GLA; Drug: Placebo for SLIT PE
Sponsor: Sanofi
Not yet recruiting
Clinical and Economic Outcomes of High Sensitivity Troponin for no ST Elevation Myocardial Infarction in Patients With Chest Pain in Emergency Departments in Italy-An Observational Study

Condition: NSTEMI - Non-ST Segment Elevation MI
Intervention:
Sponsors: Marco Marchetti; Azienda Ospedaliero Universitaria Maggiore della Carita; Azienda Sanitaria Locale ASL 6, Livorno; Azienda Ospedaliera Spedali Civili di Brescia; Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico; Ospedale Civile - Padova; S. Andrea Hospital; Azienda Policlinico Umberto I; San Carlo Public Hospital, Potenza, Italy; Azienda Ospedaliero-Universitaria Consorziale; Policlinico Universitario, Catania; Azienda Ospedaliera Sant'Anna; Ospedale di Cattinara - Azienda Universitaria Integrata -Trieste; Abbott s.r.l.; InformaPRO s.r.l.
Recruiting
Rifaximin on Visceral Hypersensitivity

Conditions: Visceral Hypersensitivity; Irritable Bowel Syndrome
Intervention: Drug: Rifaximin
Sponsors: Cedars-Sinai Medical Center; Valeant Pharmaceuticals International, Inc.
Not yet recruiting
Diagnosis of Cow's Milk Protein Allergy Among Infants and Children in Assuit University Children Hospital

Condition: Cow Milk Allergy
Intervention: Diagnostic Test: skin prick test - specific serum IgE
Sponsor: Assiut University
Not yet recruiting
Two-month Regimens Using Novel Combinations to Augment Treatment Effectiveness for Drug-sensitive Tuberculosis

Condition: Tuberculosis, Pulmonary
Interventions: Drug: Rifampicin; Drug: Isoniazid; Drug: Pyrazinamide; Drug: Ethambutol; Drug: Linezolid; Drug: Clofazimine; Drug: Rifapentine; Drug: Levofloxacin; Drug: Bedaquiline
Sponsors: University College, London; National University Hospital, Singapore; Singapore Clinical Research Institute (SCRI)
Recruiting
Soluble Epoxide Hydrolase Inhibition and Insulin Resistance

Conditions: Diabetes Mellitus; Endocrine System Diseases; Glucose Metabolism Disorders; PreDiabetes; Obesity
Interventions: Drug: GSK2256294; Drug: Placebo oral capsule
Sponsor: Vanderbilt University Medical Center
Not yet recruiting
A Study to Try to Bring Back Radioiodine Sensitivity in Patients With Advanced Thyroid Cancer.

Condition: Papillary Thyroid Cancer
Intervention: Drug: Imatinib Oral Tablet
Sponsors: AHS Cancer Control Alberta; Alberta Cancer Foundation
Not yet recruiting
S-1 Plus Gefitinib Versus Gefitinib Monotherapy in Patients With EGFR-sensitive Mutation Advanced Non-squamous NSCLC

Condition: EGFR-sensitive Mutation-positive Advanced Non-squamous Non-small Cell Lung Cancer Treated With S-1plus Gefitinib Versus Gefitinib Monotherapy
Interventions: Drug: S-1 plus Gefitinib; Drug: Gefitinib
Sponsor: Henan Cancer Hospital
Not yet recruiting
Low Dose Fat-Induced Insulin Resistance

Conditions: Diabetes Mellitus, Type 2; Insulin Resistance; Insulin Sensitivity
Intervention: Drug: Intralipid, 20% Intravenous Emulsion
Sponsor: University of Pennsylvania
Not yet recruiting
Step Down Approach in Children With Cow Milk Allergy

Condition: Allergy Milk
Interventions: Dietary Supplement: extensively hydrolyzed casein formula + LGG; Dietary Supplement: Hypoallergenic formula based on amino-acid based formula
Sponsor: Federico II University
Not yet recruiting
Evaluation of Stress Sensitivity and Hyperemotivity in Epilepsy Compared to and a Group of Healthy Volunteers

Condition: Epilepsy
Intervention: Other: Measure of emotional stressors
Sponsor: University Hospital, Toulouse
Recruiting
Drug Sensitivity Correlation Between Patient-Derived Organoid Model and Clinical Response in NSCLC Patients

Condition: NSCLC
Intervention:
Sponsor: K2 Oncology, Inc.
Recruiting
Effects of the Direct Interaction Between Streptococcus Salivarius 24SMBc and Streptococcus Oralis 89a and the Respiratory Epithelium in Children

Condition: Allergy
Interventions: Combination Product: Streptococcus salivarius 24SMBc + Strept. oralis 89a; Combination Product: fluticasone + mometasone; Other: placebo
Sponsor: Federico II University
Not yet recruiting
A Phase 3 Study of Reproxalap in Subjects With Allergic Conjunctivitis

Condition: Allergic Conjunctivitis
Interventions: Drug: Reproxalap Ophthalmic Solution (0.25%); Drug: Reproxalap Ophthalmic Solution (0.5%); Drug: Vehicle Ophthalmic Solution
Sponsor: Aldeyra Therapeutics, Inc.
Recruiting
Mepolizumab for the Treatment of Chronic Spontaneous Urticaria

Condition: Chronic Spontaneous Urticaria
Intervention: Drug: Nucala
Sponsors: Mayo Clinic; GlaxoSmithKline
Not yet recruiting
Mechanisms of Alcohol Sensitivity in AERD

Conditions: Aspirin-Sensitive Asthma With Nasal Polyps; Samter's Syndrome
Interventions: Dietary Supplement: Water; Dietary Supplement: Red wine; Dietary Supplement: Polyphenolic Compounds
Sponsor: University of Virginia
Not yet recruiting
Clinical Endpoint Bioequivalence Study of Fluticasone Propionate & Salmeterol Xinafoate (100mg/50mg)

Condition: Asthma
Interventions: Drug: Fluticasone/Salmeterol; Drug: Advair Diskus 100/50 Dry Powder Inhaler; Drug: Placebo
Sponsors: West-Ward Pharmaceutical; Pharm-Olam International
Not yet recruiting
Insulin Signaling in Skeletal Muscle

Condition: Insulin Sensitivity
Interventions: Drug: Metformin; Drug: Pioglitazone; Drug: Placebo
Sponsor: Wayne State University
Not yet recruiting
A Single-Center Evaluation of the Relative Efficacy of EM-100 Compared to Zaditor® (Ketotifen Fumarate Ophthalmic Solution 0.035%) and Vehicle

Condition: Allergic Conjunctivitis
Interventions: Drug: EM-100; Drug: Zaditor®; Drug: Vehicle
Sponsors: EyeMax, LLC; Eton Pharmaceuticals, Inc.; ORA, Inc.
Recruiting
Clinical Performance of the Histidine Rich Protein 2 (HRP2) Highly Sensitive Rapid Diagnostic Test (HS-RDT) for Malaria Diagnosis in Pregnant Women in Papua New Guinea

Conditions: Plasmodium Falciparum Malaria; Pregnancy Malaria; Diagnoses Disease
Intervention: Diagnostic Test: HS-RDT
Sponsors: Foundation for Innovative New Diagnostics, Switzerland; Burnet Institute; Papua New Guinea Institute of Medical Research
Not yet recruiting
A Phase II Study of MABp1 in Patients With Moderate to Severe Atopic Dermatitis

Condition: Atopic Dermatitis
Interventions: Drug: MABp1 Monoclonal Antibody 200 mg; Drug: MABp1 Monoclonal Antibody 400 mg
Sponsor: XBiotech, Inc.
Not yet recruiting
Status Asthmaticus on the PICU; Intravenous Salbutamol

Condition: Childhood Asthma With Status Asthmaticus
Interventions: Drug: Salbutamol; Drug: Sodium Chloride 0.9%
Sponsor: Erasmus Medical Center
Recruiting
A Study of AK002 in Patients With Eosinophilic Gastritis With or Without Eosinophilic Gastroenteritis

Condition: Eosinophilic Gastritis
Interventions: Drug: AK002; Other: Placebo
Sponsor: Allakos, Inc.
Not yet recruiting
A Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, Immunogenicity of N-Rephasin® SAL200 in Healthy Male Volunteers

Conditions: Healthy Volunteers; Anti-Bacterial Agents; Methicillin-Resistant Staphylococcus Aureus; Methicillin-Sensitive Staphylococcus Aureus Infection
Interventions: Biological: N-Rephasin® SAL200; Other: INT200-Placebo
Sponsor: Intron Biotechnology, Inc.
Recruiting
An Observational Study of Combination of Pegylated Liposomal Doxorubicin and Trabectedin in Routine Practice in Patients With Recurrent Partial-platinum Sensitive Ovarian Cancer

Condition: Ovarian Cancer
Intervention: Drug: Trabectedin + PLD
Sponsors: Suriya Yessentayeva; Johnson & Johnson
Recruiting
Visual Quality and Contrast Sensitivity Function After Corneal Transplantation

Condition: Keratopathy
Intervention: Procedure: keratoplasty
Sponsor: Zhongshan Ophthalmic Center, Sun Yat-sen University
Recruiting
Accuracy of AOBP in a Chinese Population

Condition: Hypertension
Intervention: Diagnostic Test: WatchBP Office (BP measurement machine)
Sponsor: Chinese University of Hong Kong
Not yet recruiting
Scratch and Sleep Quantification in Atopic Dermatitis

Conditions: Atopic Dermatitis; Pruritus; Sleep Disturbance
Intervention:
Sponsors: University of Rochester; Pfizer
Not yet recruiting
A Study Evaluating Bilastine Ophthalmic Solution 0.6% in the Conjunctival Allergen Challenge (Ora-CAC®) Model

Condition: Allergic Conjunctivitis
Interventions: Drug: Bilastine Ophthalmic Solution 0.6%; Drug: Ketotifen Ophthalmic Solution 0.025% (Zaditen); Drug: Vehicle of Bilastine Ophthalmic Solution
Sponsors: Faes Farma, S.A.; ORA, Inc.
Recruiting
Internet-delivered CBT for Asthma-related Anxiety: Feasibility

Condition: Asthma
Intervention: Behavioral: Internet-CBT for anxiety-related asthma
Sponsor: Karolinska Institutet
Not yet recruiting
Efficacy and Safety Study of BCX7353 as an Oral Treatment for the Prevention of Attacks in HAE

Conditions: Hereditary Angioedema; HAE
Interventions: Drug: BCX7353 capsules; Drug: Placebo oral capsule
Sponsor: BioCryst Pharmaceuticals
Recruiting
Revitalization of Damaged Skin Due to Chronic Skin Diseases

Conditions: Chronic Eczema; Psoriasis; Atopic Dermatitis
Intervention: Combination Product: ACE CSD
Sponsor: Ace Cells Lab Limited
Not yet recruiting
The German Version of the Awareness of Social Inference Test

Condition: Social Cognition
Intervention:
Sponsor: University Hospital, Basel, Switzerland
Recruiting
Minirigid Versus Conventional Rigid Thoracoscopy in Undiagnosed Pleural Effusions

Condition: Pleural Effusion
Interventions: Device: Mini-thoracoscopy; Device: Conventional rigid thoraoscopy
Sponsor: Postgraduate Institute of Medical Education and Research
Recruiting
COPE for Children With Asthma: Intervention for Children With Asthma

Conditions: Childhood Asthma; Childhood Anxiety Disorder; Childhood Depression
Intervention: Behavioral: COPE for Asthma
Sponsors: Ohio State University; American Nurses Foundation; Sigma Theta Tau International/Midwest Nursing Research Society; National Association of Pediatric Nurse Practitioners; Sigma Theta Tau Epsilon Branch
Recruiting
Direct Tumor Microinjection and FDG-PET in Testing Drug Sensitivity in Patients With Relapsed or Refractory Non-Hodgkin Lymphoma, Hodgkin Lymphoma, or Stage IV Breast Cancer

Conditions: Breast Adenocarcinoma; Recurrent Breast Carcinoma; Recurrent Hodgkin Lymphoma; Recurrent Mycosis Fungoides; Recurrent Non-Hodgkin Lymphoma; Recurrent Primary Cutaneous T-Cell Non-Hodgkin Lymphoma; Refractory Hodgkin Lymphoma; Refractory Mycosis Fungoides; Refractory Nodal Marginal Zone Lymphoma; Refractory Non-Hodgkin Lymphoma; Refractory Primary Cutaneous T-Cell Non-Hodgkin Lymphoma; Stage IV Breast Cancer AJCC v6 and v7
Interventions: Drug: Belinostat; Drug: Carfilzomib; Biological: Daratumumab; Drug: Fludeoxyglucose F-18; Drug: Gemcitabine Hydrochloride; Other: Laboratory Biomarker Analysis; Biological: Nivolumab; Biological: Obinutuzumab; Biological: Pembrolizumab; Procedure: Positron Emission Tomography; Biological: Rituximab; Drug: Romidepsin; Other: Saline; Biological: Trastuzumab
Sponsors: Mayo Clinic; National Cancer Institute (NCI)
Recruiting
Systematic and Mechanism-based Approach to Rational Treatment Trials of Blood Cancer

Conditions: Hematologic Diseases; Treatment
Intervention: Diagnostic Test: ex-vivo drug response assay
Sponsors: University Hospital Heidelberg; German Cancer Research Center
Not yet recruiting
An Open-label Study to Evaluate Correct Use and Ease of Use of the ELLIPTA DPI in Pediatric Subjects With Asthma

Condition: Asthma
Interventions: Drug: Placebo DPI; Device: ELLIPTA DPI; Other: Ease of use questionnaires
Sponsor: GlaxoSmithKline
Not yet recruiting
Safety, Tolerability and Pharmacokinetics of PUR1900 (Itraconazole Powder) in Healthy Volunteers and Adults With Asthma

Condition: Asthma
Interventions: Drug: Itraconazole Powder; Drug: Itraconazole 200 mg
Sponsor: Pulmatrix Inc.
Recruiting
Non-Eosinophilic Neutrophilic Asthma

Condition: Neutrophilic Asthma
Intervention: Diagnostic Test: Induced sputum
Sponsors: Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau; Spanish Clinical Research Network - CAIBER
Recruiting
Effects of Home Gluten Immunogenic Peptide Testing on Children With Celiac Disease

Conditions: Celiac Disease; Gluten Sensitivity; Gluten Enteropathy; Gastrointestinal Disease; Digestive System Disease; Diet Modification; Intestinal Disease; Malabsorption Syndromes; Patient Compliance; Diagnostic Self Evaluation; Quality of Life
Intervention: Device: Immunochromatographic lateral flow test
Sponsors: Boston Children’s Hospital; Glutenostics, LLC
Not yet recruiting
A Randomized Study to Establish the Efficacy of Oral Ice Exposure During Oxaliplatin Infusion in Preventing Oral Cold Sensitivity

Condition: GI Patients on Oxaliplatin Containing Regimen
Intervention: Drug: Oxaliplatin
Sponsor: Abramson Cancer Center of the University of Pennsylvania
Recruiting
Study of Magnitude and Prediction of Response to Omalizumab and Mepolizumab in Adult Severe Asthma.

Condition: Severe Asthma
Interventions: Drug: Randomisation to omalizumab; Drug: Randomisation to mepolizumab
Sponsors: Cliniques universitaires Saint-Luc- Université Catholique de Louvain; University Hospital, Ghent; University Hospital of Liege; CHU de Charleroi; Erasme University Hospital; Centre Hospitalier Universitaire Dinant Godinne - UCL Namur; Universitair Ziekenhuis Brussel; Brugmann University Hospital; Grand Hôpital de Charleroi; AZ Delta Roeselare; Centre Hospitalier Universitaire Saint Pierre; Katholieke Universiteit Leuven
Not yet recruiting
Treatment for Affect Dimensions

Conditions: Anhedonia; Depression; Anxiety
Interventions: Behavioral: Positive Affect Treatment; Behavioral: Negative Affect Treatment
Sponsors: University of California, Los Angeles; Southern Methodist University
Recruiting
Serotonin Levels in Atopic Dermatitis Patients

Condition: Dermatologic Disease
Intervention: Diagnostic Test: Serum serotonin level
Sponsor: Assiut University
Not yet recruiting
Effects of Carnitine Supplementation on Liver and Muscle

Conditions: Non-Alcoholic Fatty Liver Disease; Insulin Resistance
Interventions: Dietary Supplement: L-Carnitine tartrate; Dietary Supplement: Meal Replacement Drink; Dietary Supplement: Maltodextrin
Sponsors: University of Nottingham; Nottingham University Hospitals NHS Trust; National Institute for Health Research, United Kingdom
Recruiting
Trial of Rucaparib in Patients With Metastatic Hormone-Sensitive Prostate Cancer Harboring Germline DNA Repair Gene Mutations

Condition: Prostate Cancer Metastatic
Intervention: Drug: Rucaparib
Sponsor: Sidney Kimmel Comprehensive Cancer Center
Not yet recruiting
Influences of Different Temporary Cement on Retention Rate of Temporary Crowns

Conditions: MTA; Calcium Hydroxide; Dental Crown
Interventions: Procedure: Temporary cement based on Calcium Hydroxide; Procedure: MTA temporary cement
Sponsor: Federal University of Uberlandia
Recruiting
Influence of the Composition of Temporary Restorative Material in Vital Teeth

Conditions: MTA; Dental Restoration, Temporary
Interventions: Procedure: Carie removal; Procedure: Relative isolation; Procedure: Manipulation of the temporary material based on Zinc Oxide and Eugenol; Procedure: Manipulation of the temporary material based on Mineral trioxide aggregate; Procedure: Material insertion on the cavity; Procedure: Finishing the temporary direct restoration
Sponsor: Federal University of Uberlandia
Not yet recruiting
Benralizumab for Eosinophilic Gastritis

Condition: Eosinophilic Gastritis or Gastroenteritis
Interventions: Biological: Benralizumab; Biological: Placebo
Sponsors: Children's Hospital Medical Center, Cincinnati; AstraZeneca
Recruiting
Proof of Concept Study to Investigate ANB020 Activity in Adult Patients With Severe Eosinophilic Asthma

Condition: Eosinophilic Asthma
Interventions: Drug: ANB020; Drug: Placebo
Sponsor: AnaptysBio, Inc.
Recruiting
Anti-IgE Monoclonal Antibody Treatment in Patients With Allergic Asthma.

Condition: Asthma, Allergic
Interventions: Drug: CMAB007; Drug: Symbicort; Drug: Seretide; Drug: Ventolin; Drug: placebo
Sponsor: Shanghai Biomabs Pharmaceutical Co., Ltd.
Recruiting
A Long Term Safety Study of BCX7353 in Hereditary Angioedema

Conditions: Hereditary Angioedema; HAE; Prophylaxis
Intervention: Drug: BCX7353
Sponsor: BioCryst Pharmaceuticals
Recruiting
Intestinal Microbiota and Treatment of GD

Condition: Microbiota
Interventions: Drug: Methimazole Pill; Drug: Propylthiouracil Pill
Sponsor: First Affiliated Hospital of Harbin Medical University
Recruiting
The Effects of Primary Pterygium on Contrast Sensitivity Preoperatively and Postoperatively

Condition: Primary Pterygium
Intervention: Procedure: Pterygium surgery
Sponsor: Zhongshan Ophthalmic Center, Sun Yat-sen University
Recruiting
Non-carious Cervical Lesions and Treatments

Condition: Tooth Sensitivity
Interventions: Device: Experimental: • Group LA; Device: Placebo Comparator: • Group LA-P; Other: Experimental: • Group DE; Other: Placebo Comparator: • Group DE-P; Other: Experimental: • Group RGI; Other: Experimental: Group RX
Sponsor: University of Sao Paulo
Recruiting
A Community-based Assessment of Skin Care, Allergies, and Eczema

Conditions: Atopic Dermatitis; Atopic Disorders; Eczema; Atopic Eczema
Intervention: Other: Participant choice of over-the-counter emollients: Vaseline, Vanicream, CeraVe Healing Ointment, CeraVe cream, Cetaphil cream
Sponsors: Oregon Health and Science University; University of Wisconsin, Madison; University of Colorado, Denver; Duke University
Not yet recruiting
Efficacy and Safety of GSP 301 Nasal Spray in Children (Aged 6 to Under 12 Years) With Seasonal Allergic Rhinitis (SAR)

Condition: Seasonal Allergic Rhinitis (SAR)
Interventions: Drug: GSP 301 NS; Drug: GSP 301 Placebo NS
Sponsor: Glenmark Specialty S.A.
Recruiting
A Study of the Efficacy and Safety of Orvepitant in Subjects With Pruritus Associated With Atopic Dermatitis

Conditions: Pruritus; Atopic Dermatitis
Interventions: Drug: Orvepitant; Drug: Placebo
Sponsor: Nerre Therapeutics Ltd.
Not yet recruiting
Salmeterol Xinafoate and Fluticasone Propinate Powder for Inhalation for Asthma

Condition: Asthma
Interventions: Drug: Salmeterol Xinafoate and Fluticasone Propinate Powder; Drug: Seretide
Sponsor: Jiangsu Chia-tai Tianqing Pharmaceutical Co.,Ltd
Recruiting
Comparison on Succinylcholine Onset Time Assessed by Train of Four Stimulation Versus Clinical Judgment During Rapid Sequence Induction of Anesthesia

Conditions: Suxamethonium Sensitivity; Aspiration of Gastric Contents Into Respiratory Tract, Part Unspecified
Intervention:
Sponsor: University Hospital, Caen
Recruiting
Mediterranean Style Diet and Low Glycemic Responses

Condition: Insulin Sensitivity
Intervention: Other: Hi GI
Sponsors: Purdue University; Federico II University; University of Agriculture Science, Uppsala, Sweden
Recruiting
Assessment of BladderLight SurvEILlance

Condition: Bladder Cancer
Intervention: Device: BladderLight®
Sponsors: Cambridge University Hospitals NHS Foundation Trust; Cytosystems Ltd
Not yet recruiting
Efficacy of Topical Coal Tar in Children With Atopic Dermatitis

Condition: Atopic Dermatitis
Interventions: Drug: Topical coal tar; Drug: Topical corticosteroids
Sponsor: Radboud University
Recruiting
The Development of a Screening Assay by LC-MS/MS to Monitor Adherence to Asthma Treatment

Condition: Asthma
Intervention:
Sponsor: Heart of England NHS Trust
Not yet recruiting
High Intensity Interval Training and Skeletal Muscle Insulin Sensitivity

Condition: Obese, Pre-diabetics
Interventions: Behavioral: High-intenstiy interval training; Dietary Supplement: Insulinogenic, carbohydrate-rich drink
Sponsors: Maastricht University; Netherlands Organisation for Scientific Research
Not yet recruiting
Lung-Resident Memory Th2 Cells in Asthma

Condition: Asthma, Allergic
Interventions: Procedure: Bronchoscopy/BAL; Procedure: Airway Brushing; Procedure: Endobronchial Biopsy
Sponsors: Andrew D. Luster, M.D.,Ph.D.; National Institute of Allergy and Infectious Diseases (NIAID)
Not yet recruiting
Oral Challenge in the Pediatric ED

Conditions: Penicillin Allergy; Pediatric Emergency Medicine
Intervention: Drug: Amoxicillin
Sponsor: Medical College of Wisconsin
Recruiting
Eye Drops Study for Myopia Control in Schoolchildren

Conditions: Myopia, Progressive; Atropine Allergy
Intervention: Drug: eye drops
Sponsor: Chang Gung Memorial Hospital
Recruiting
Foster 100/6 mg NEXThaler Versus Foster 100/6mg Pressurized Metered-dose Inhaler (pMDI) in Patients With Controlled Asthma.

Condition: Asthma
Interventions: Drug: Foster 100/6mg NEXThaler; Drug: Foster 100/6mg pMDI
Sponsor: Chiesi Farmaceutici S.p.A.
Recruiting
Health-Smart for Weight Loss at UF Jax Clinics

Condition: Obesity
Intervention: Behavioral: Health Smart for Weight Loss
Sponsors: University of Florida; Patient-Centered Outcomes Research Institute
Not yet recruiting
Effects of Transcutaneous Acupoint Electrical Stimulation on Postoperative HRV and Hs-cTnT of Elderly With CHD

Conditions: Coronary Artery Disease; Anesthesia
Interventions: Procedure: transcutaneous acupoint electrical stimulation; Procedure: sham transcutaneous acupoint electrical stimulation
Sponsor: Hebei Medical University Third Hospital
Recruiting
Role of Endothelial Cells in the Pathogenesis of Chronic Urticaria.

Condition: Chronic Urticaria
Interventions: Procedure: Punch Biopsy; Procedure: Blood sampling
Sponsor: Olivier Michel
Recruiting
Mast Cell Activation Test in Allergic Disease

Conditions: Asthma; Mastocytosis; Mast Cell Activation Syndrome; Food Allergy; Chronic Idiopathic Urticaria; Anaphylaxis; Eczema
Intervention:
Sponsors: Hong Kong Sanatorium & Hospital; Chinese University of Hong Kong; Stanford University
Not yet recruiting
Multicentre Study of Olaparib Maintenance Monotherapy in Platinum Sensitive Relapsed Non gBRCAm Ovarian Cancer Patients

Condition: Non-Germline BRCA Mutated Ovarian Cancer
Intervention: Drug: Olaparib
Sponsors: AstraZeneca; Quintiles, Inc.; Myriad Genetics, Inc.; Covance; Theradex; Parexel
Recruiting
A Study of the Effect of 20 mg Ambroxol Hydrochloride on Acute Cough.

Condition: Cough
Intervention: Drug: Ambroxol Hydrochloride
Sponsors: Hull and East Yorkshire Hospitals NHS Trust; Sanofi
Not yet recruiting
Inhaler Technique in Elderly Patients: Impact on Disease Exacerbations

Conditions: Asthma; COPD
Intervention: Behavioral: Inhaler technique education
Sponsor: Aveiro-Aradas Family Health Unit
Not yet recruiting
Pain in Autism Spectrum Disorder

Condition: High Functioning Autism Spectrum Disorder
Intervention:
Sponsor: Rambam Health Care Campus
Not yet recruiting
A Study to Assess the Efficacy and Safety of AK002 in Subjects With Antihistamine-Resistant Chronic Urticaria

Condition: Chronic Urticaria
Intervention: Biological: AK002
Sponsor: Allakos, Inc.
Recruiting
Study to Investigate the Efficacy and Safety of QGE031 in Adolescent Patients With Chronic Spontaneous Urticaria (CSU)

Condition: Chronic Spontaneous Urticaria
Interventions: Drug: Ligelizumab; Drug: Placebo
Sponsor: Novartis Pharmaceuticals
Not yet recruiting
Peer-Administered Asthma Self-Management Intervention in Urban Middle Schools

Condition: Asthma
Interventions: Behavioral: ASMAS; Behavioral: Asthma education plus child health
Sponsors: Rhode Island Hospital; University of Puerto Rico
Not yet recruiting
The Relationship Between Salt Restriction and Taste Sensitivity in Patients With Chronic Kidney Disease

Conditions: Renal Insufficiency, Chronic; Chronic Kidney Diseases
Intervention: Other: salt restriction education
Sponsor: Peking University First Hospital
Not yet recruiting
MRI to Assess Fibrosis in Eosinophilic Esophagitis Patients

Condition: Eosinophilic Esophagitis
Intervention: Device: MRI to detect inflammation and fibrosis in subjects with EoE
Sponsor: Mayo Clinic
Recruiting
A Study to Evaluate Changes in Nasal Airflow of Loratadine/Pseudoephedrine Tablet and Fluticasone Propionate Nasal Spray in Subjects Following Allergen Exposure

Condition: Rhinitis, Allergic
Interventions: Drug: loratadine + pseudoephedrine sulfate (BAY818725/Claritin-D); Drug: Placebo tablet; Drug: Fluticasone Propionate; Drug: Placebo spray
Sponsor: Bayer
Recruiting
Apatinib With Pembrolizumab in Previously Treated Advanced Malignancies

Conditions: Advanced Malignancies; Urothelial Carcinoma; MSI-H or dMMR Solid Tumors; Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma
Interventions: Drug: Apatinib; Drug: Pembrolizumab
Sponsors: University of Utah; LSK BioPartners Inc.
Not yet recruiting
A Study of Lebrikizumab in Patients With Moderate-to-Severe Atopic Dermatitis

Condition: Atopic Dermatitis
Interventions: Biological: Lebrikizumab; Drug: Placebos
Sponsor: Dermira, Inc.
Recruiting
The Incidence of Glistenings in the 2017 Intraocular Lenses Made by Alcon and Abbott Medical Optics

Conditions: Cataracts; Visual Acuity Reduced Transiently; Loss of Visual Contrast Sensitivity; Functional Visual Loss
Interventions: Device: Alcon 1 piece SA60AT lens; Device: AMO 1-piece AABOO lens
Sponsors: University of Toronto; Kensington Eye Institute
Recruiting
In-home Use Test of the New Modified Diprobase Formulation to Assess the Safety and Tolerability in Infants and Children Under Physician's Control

Condition: Atopic Dermatitis
Intervention: Device: BAY987534
Sponsor: Bayer
Not yet recruiting
Clinical Study on Chinese Children's Asthma Action Plan

Condition: Asthma in Children
Interventions: Other: asthma action plan management group; Other: conventional management group
Sponsors: Beijing Children's Hospital; Tian Jing Children’s Hospital; Capital Institute of Pediatrics, China; Peking University Third Hospital; Beijing Tsinghua Chang Gung Hospital; Tianjin Medical University Second Hospital; Peking University Bin Hai Hospital; The First Hospital of Qinhuangdao; Tangshan Maternal and Child Health Hospital; Children's Hospital of Hebei Province
Not yet recruiting
Phenotyping Asthma for Bronchial Thermoplasty

Condition: Severe Asthma
Intervention:
Sponsors: Massachusetts General Hospital; National Heart, Lung, and Blood Institute (NHLBI)
Not yet recruiting
High Throughput Drug Sensitivity and Genomics Data in Developing Individualized Treatment in Patients With Relapsed or Refractory Multiple Myeloma or Plasma Cell Leukemia

Conditions: Plasma Cell Leukemia; Recurrent Plasma Cell Myeloma; Refractory Plasma Cell Myeloma
Interventions: Procedure: Biospecimen Collection; Device: High Throughput Screening; Other: Laboratory Biomarker Analysis
Sponsors: University of Washington; National Cancer Institute (NCI)
Recruiting
A Study of Baricitinib (LY3009104) in Adult Participants With Moderate to Severe Atopic Dermatitis

Condition: Atopic Dermatitis
Interventions: Drug: Baricitinib; Drug: Placebo
Sponsors: Eli Lilly and Company; Incyte Corporation
Recruiting
A Phase 1b Study Assessing the PK, PD, Safety & Tolerability of SB414 in Atopic Dermatitis

Condition: Atopic Dermatitis
Interventions: Drug: SB414 2%; Drug: SB414 6%; Drug: Vehicle
Sponsors: Novan, Inc.; Novella Clinical
Recruiting
Efficacy and Safety of Sipjeondaebo-tang on Korean Patients With Cold Hypersensitivity in the Hands and Feet (SDT)

Condition: Cold Hypersensitivity
Interventions: Drug: Sipjeondaebo-tang Granule; Drug: Placebo
Sponsors: Gachon University Gil Oriental Medical Hospital; Kyunghee University Oriental Medical Center; Kyung Hee University Hospital at Gangdong; Semyung University second affiliated oriental medical hospital at Chungju; Sangji University Oriental Medical Hospital
Recruiting
Icotinib as Consolidation Therapy After Chemoradiotherapy in EGFR-Mutant Stage IIIA-IIIB Non-small Cell Lung Cancer

Conditions: EGFR Gene Mutation; Non Small Cell Lung Cancer Stage IIIA; Non Small Cell Lung Cancer Stage IIIB
Intervention: Drug: Icotinib
Sponsor: Betta Pharmaceuticals Co.,Ltd.
Recruiting
Personalized Feedback for Smokers With Elevated Anxiety Sensitivity

Conditions: Anxiety Disorders; Anxiety; Tobacco Dependence; Smoking, Cigarette; Smoking, Tobacco
Interventions: Behavioral: Personalized Feedback Intervention; Behavioral: Smoking Information Control
Sponsors: University of Houston; National Institute on Drug Abuse (NIDA)
Recruiting
A Long-term Study of Baricitinib (LY3009104) With Topical Corticosteroids in Adults With Moderate to Severe Atopic Dermatitis That Are Not Controlled With Cyclosporine or for Those Who Cannot Take Oral Cyclosporine Because it is Not Medically Advisable

Condition: Atopic Dermatitis
Interventions: Drug: Baricitinib; Drug: Placebo; Drug: Topical corticosteroid
Sponsors: Eli Lilly and Company; Incyte Corporation
Not yet recruiting
Study of Adult Patients Receiving DUPIXENT® for Atopic Dermatitis (AD)

Condition: Dermatitis, Atopic
Intervention: Drug: Dupilumab
Sponsors: Regeneron Pharmaceuticals; Sanofi
Not yet recruiting
Small Airway Obstruction in Asthma, COPD, ACOS

Conditions: Asthma; COPD; Asthma-COPD Overlap Syndrome
Intervention: Other: No any intervention
Sponsor: Mahidol University
Recruiting
Allergic Versus Non Allergic Hypersensitivity Drug Reaction (BdDAllergo)

Condition: Allergic Hypersensitivity Drug Reaction Versus Non-allergic Hypersensitivity Drug Reaction Cross Reaction
Intervention:
Sponsor: University Hospital, Grenoble
Recruiting
Ai Chi Method for Children With Asthma

Conditions: Asthma; Child; Respiratory Disease; Hydrotherapy; Respiratory Tract Diseases; Respiratory Hypersensitivity; Respiration Disorders
Interventions: Other: Ai Chi; Other: Asthma education
Sponsor: Universidade Federal do Rio Grande do Norte
Recruiting
A Study of the Pharmacokinetics, Safety and Tolerability of Single Doses of VR647 Inhalation Suspension Administered Using the VR647 Inhalation System in Children With Wheezing, Reactive Airway Disease or Mild Asthma

Conditions: Wheezing; Reactive Airway Disease; Mild Asthma
Interventions: Combination Product: VR647 Inhalation Suspension (budesonide) 1 mg/2 mL delivered by the VR647 Inhalation System; Combination Product: 1 mg/2 mL Pulmicort Respules delivered by a conventional jet nebulizer
Sponsor: Vectura Limited
Recruiting
Study to Evaluate Efficacy and Safety of PF-04965842 With or Without Topical Medications in Subjects Aged 12 Years and Older With Moderate to Severe Atopic Dermatitis

Condition: Dermatitis, Atopic
Interventions: Drug: PF-04965842 100 mg; Drug: PF-04965842 200 mg; Drug: Placebo
Sponsor: Pfizer
Recruiting
Gefitinib Combine Radiotherapy as Therapy for Patients With NSCLC Harbouring Sensitive Mutations of EGFR

Condition: Lung Cancer
Intervention: Drug: Gefitinib
Sponsors: Qilu Pharmaceutical Co., Ltd.; China-Japan Friendship Hospital; Beijing Cancer Hospital; Cancer Institute and Hospital, Chinese Academy of Medical Sciences; Chinese PLA General Hospital
Not yet recruiting
The Effect of Per Oral Immunotherapy in Severe Milk, Peanut and Egg Allergy in Adults

Condition: Food Allergy
Intervention: Dietary Supplement: Oral immunotherapy
Sponsor: Helsinki University Central Hospital
Recruiting
Peak Expiratory Flow Rate for Emergency Department Management of Acute Asthma Exacerbation

Condition: Asthma
Interventions: Other: Peak Expiratory Flow Rate (PEFR); Other: Standard Clinical Judgement
Sponsor: Minneapolis Medical Research Foundation
Recruiting
Early Detection of Cardiomyopathy by Speckle Echo, High Sensitive Troponin and Cardiac Ryanodine Receptors

Condition: Chemotherapy Effect
Intervention: Drug: Chemotherapy, Cancer, Anthracyclines
Sponsor: Assiut University
Not yet recruiting
Sensitization Study of ATx201 in Healthy Volunteers

Condition: Sensitivity, Contact
Interventions: Drug: ATx201; Drug: ATx201 Placebo Gel
Sponsor: AntibioTx A/S
Recruiting
A Clinical Method Development Study to Characterise The Efficacy of a Dentifrice For The Relief Of Dentin Hypersensitivity

Condition: Dentin Sensitivity
Interventions: Drug: Dentifrice containing 5% w/w KNO3 and 0.454% w/w SnF2 (1100 ppm fluoride).; Drug: Dentifrice containing 0.454% w/w SnF2 (1100 ppm fluoride).
Sponsor: GlaxoSmithKline
Not yet recruiting
Telehealth Enhanced Asthma Management

Condition: Asthma
Intervention: Other: Asthma Subspecialty Follow-up Visits
Sponsor: Arkansas Children's Hospital Research Institute
Recruiting
Open-Label Study of RVT-501 Topical Ointment in Pediatric Patients With Atopic Dermatitis

Condition: Atopic Dermatitis
Intervention: Drug: RVT-501 0.5% topical ointment
Sponsor: Dermavant Sciences GmbH
Recruiting
Acupuncture and Cinesiotherapy on Skin Sensitivity of Patients With Breast Cancer Subject to Chemotherapy With Taxans

Condition: Chemotherapy Effect
Interventions: Other: Stiper; Other: acupuncture; Other: Control
Sponsor: Federal University of São Paulo
Recruiting
Specific Oral Tolerance Induction (SOTI) to Children With IgE-mediated Wheat Allergy

Condition: Wheat Allergy
Intervention: Dietary Supplement: Wheat spaghetti
Sponsor: Athens General Children's Hospital "Pan. & Aglaia Kyriakou"
Recruiting
Study to Evaluate the Efficacy and Safety of Tezepelumab in Reducing Oral Corticosteroid Use in Adults With Oral Corticosteroid Dependent Asthma

Condition: Asthma
Interventions: Biological: Tezepelumab; Other: Placebo
Sponsors: AstraZeneca; Amgen
Recruiting
Air Pollution, Asthma and Circadian Clocks

Conditions: Asthma; Healthy
Intervention: Other: Observational
Sponsor: University of Pennsylvania
Recruiting
Perioperative Anaphylaxis in an Egyptian Population.

Conditions: Perioperative/Postoperative Complications; Drug-Induced Anaphylaxis
Intervention:
Sponsor: Assiut University
Recruiting
Anxiety About Casual Exposure to Food Allergens

Condition: Food Allergy
Interventions: Behavioral: Behavioral intervention group; Behavioral: Education
Sponsor: Icahn School of Medicine at Mount Sinai
Recruiting
A Study to Assess the Biological Potency of Peanut Allergen Extract in Adolescent and Adult Peanut Allergic Subjects

Condition: Peanut Allergy
Intervention: Drug: DBV712 IHRP
Sponsor: DBV Technologies
Recruiting
The Effects of Hesperidin on Biochemical Factors and Hepatic Fibrosis in Nonalcoholic Fatty Liver Disease

Condition: Non Alcoholic Steatohepatitis
Interventions: Dietary Supplement: Hesperidin; Other: control
Sponsor: National Nutrition and Food Technology Institute
Recruiting
The Effects of Hesperidin and Flaxseed on Biochemical Factors and Hepatic Fibrosis in Nonalcoholic Fatty Liver Disease

Condition: Non Alcoholic Steatohepatitis
Interventions: Dietary Supplement: hesperidin and flaxseed; Other: control
Sponsor: National Nutrition and Food Technology Institute
Recruiting
Journey of Patients With Vasculitis From First Symptom to Diagnosis

Conditions: Vasculitis; Systemic Vasculitis; Behcet's Disease; CNS Vasculitis; Cryoglobulinemic Vasculitis; Eosinophilic Granulomatous Vasculitis; Temporal Arteritis; Giant Cell Arteritis; Granulomatosis With Polyangiitis; Wegener Granulomatosis; Henoch Schonlein Purpura; IgA Vasculitis; Microscopic Polyangiitis; Polyarteritis Nodosa; Takayasu Arteritis; Urticarial Vasculitis
Intervention: Other: Online Questionnaire
Sponsor: University of Pennsylvania
Recruiting
Atopic Dermatitis: Early Gene Expression Changes as Predictors of Therapeutic Response to Narrow-band UVB Treatment

Condition: Atopic Dermatitis
Intervention: Other: narrow-band UVB
Sponsor: Oslo University Hospital
Recruiting
Toxicity & Pharmacokinetics of 2 & 3-weekly Docetaxel in Metastatic Hormone-Sensitive Prostate Cancer (mHSPC)

Condition: Metastatic Hormone-Sensitive Prostate Cancer
Interventions: Drug: docetaxel 50mg/m2; Drug: docetaxel 75mg/m2
Sponsor: Peng Wang
Not yet recruiting
Clinical Study of UMOD MKCC2 Interaction on Salt-sensitivity in Hypertension

Conditions: Cardiovascular Diseases; Hypertension
Intervention: Drug: Torasemide 5Mg Tablet
Sponsors: NHS Greater Glasgow and Clyde; University of Glasgow; British Heart Foundation
Recruiting
Evaluation of the Right Use of Inhaled Therapeutics

Condition: COPD Asthma
Intervention:
Sponsor: Association Nationale pour les Traitements A Domicile, les Innovations et la Recherche
Not yet recruiting
BE Study of Fluticasone Propionate/Salmeterol Inhalation Powder in Asthma Patients

Condition: Bronchial Asthma
Interventions: Drug: Fluticasone propionate/salmeterol 100/50 µg; Other: Placebo; Drug: Advair Diskus 100/50 Dry Powder Inhaler, 60 ACTUAT
Sponsor: Cipla Ltd.
Not yet recruiting
Repeat Dose Study of GSK3772847 in Participants With Moderate to Severe Asthma With Allergic Fungal Airway Disease (AFAD)

Condition: Asthma
Interventions: Drug: GSK3772847; Drug: Placebo
Sponsor: GlaxoSmithKline
Not yet recruiting
Efficacy and Safety of Fucicort® Lipid Cream Compared to Combination Treatment With Fucidin® Cream Followed by Betamethasone (Lianbang Beisong®) Cream and Fucicort® Lipid Cream Vehicle in Clinically Infected Atopic Dermatitis/Eczema

Condition: Infected Atopic Dermatitis/Eczema
Interventions: Drug: Fucicort® Lipid cream; Drug: Fucidin® cream; Drug: Fucicort® Lipid cream vehicle; Drug: betamethasone (Lianbang Beisong®) cream
Sponsor: LEO Pharma
Not yet recruiting
Study of RVT-501 Topical Ointment in Pediatric Patients With Atopic Dermatitis

Condition: Atopic Dermatitis
Interventions: Drug: RVT-501 0.5% ointment; Drug: Vehicle ointment
Sponsor: Dermavant Sciences GmbH
Recruiting
Effect of Mediterranean Diet During Pregnancy on Gut Microbiota and on the Epigenetics

Condition: Food Allergy
Intervention: Behavioral: mediterranean diet
Sponsor: Federico II University
Recruiting
Conditioned Pain Modulation in Chronic Neck Pain Patients

Condition: Neck Pain
Interventions: Other: Patients with chronic neck pain; Other: Subjects without chronic neck pain
Sponsor: Peking University People's Hospital
Not yet recruiting
Promoting Partnership and Improving Self-Management for Children With Persistent Asthma

Condition: Asthma in Children
Intervention: Other: Nurse-delivered education
Sponsors: University of Rochester; New York State Department of Health
Not yet recruiting
Radium Ra 223 Dichloride, Hormone Therapy and Stereotactic Body Radiation Therapy in Treating Patients With Metastatic Prostate Cancer

Condition: Prostate Adenocarcinoma
Interventions: Drug: Leuprolide Acetate; Drug: Goserelin Acetate; Radiation: Stereotactic Body Radiation Therapy; Radiation: Radium Ra 223 Dichloride; Other: Laboratory Biomarker Analysis
Sponsor: City of Hope Medical Center
Recruiting
Role of Extracellular Matrix in the Development of Airway Remodeling in Asthma

Conditions: Allergic Asthma; Airway Remodelling; Extracellular Matrix Alteration
Interventions: Procedure: Bronchial challenge with allergen; Other: Co-culture formation; Other: Inhibition of Wnt and Smad signaling pathways; Other: Extracellular matrix turnover and deposition assessment; Biological: Dermatophagoides pteronyssinus allergen; Device: Dosimeter ProvoX (Ganshorn); Biological: Eosinophils; Biological: Airway smooth muscle cells; Biological: Fibroblasts
Sponsors: Lithuanian University of Health Sciences; Research Council of Lithuania; University of Groningen
Recruiting
Effect of Dupilumab (Anti-IL4Rα) on the Host-Microbe Interface in Atopic Dermatitis

Condition: Atopic Dermatitis (AD)
Interventions: Drug: Dupilumab; Drug: Placebo
Sponsors: National Institute of Allergy and Infectious Diseases (NIAID); Regeneron Pharmaceuticals; Sanofi; Atopic Dermatitis Research Network
Not yet recruiting
Assessment of Treatment Patterns of Severe Asthmatic Patients Across the Gulf Region - SevEos Study

Condition: Severe Asthma
Intervention:
Sponsor: AstraZeneca
Recruiting
Efficacy of FLUTIFORM ® vs Seretide® in Moderate to Severe Persistent Asthma in Subjects Aged ≥12 Years

Condition: Asthma
Interventions: Drug: Fluticasone/ Formoterol; Drug: fluticasone/ salmeterol
Sponsor: Mundipharma (China) Pharmaceutical Co. Ltd
Recruiting
Evaluation of SAR440340 and as Combination Therapy With Dupilumab in Moderate-to-Severe Asthma Patients

Condition: Asthma
Interventions: Drug: SAR440340/REGN3500; Drug: Dupilumab; Drug: Fluticasone or Fluticasone/salmeterol combination; Drug: Placebo for SAR440340 (REGN3500); Drug: Placebo for dupilumab
Sponsors: Sanofi; Regeneron Pharmaceuticals
Recruiting
Effect of Sublingual Immunotherapy in Patients With Atopic Dermatitis

Conditions: Atopic Dermatitis; Effects of Immunotherapy
Interventions: Drug: Mite extract sublingual immunotherapy (SLIT); Other: Placebo
Sponsors: Casa Espirita Terra de Ismael; Fundação de Amparo à Pesquisa do Estado de São Paulo
Recruiting
Clinical Evaluation for Sarcoma Originated From Bone

Conditions: Sensitivity; Specificity; Histological Response; Survival
Intervention:
Sponsors: Peking University People's Hospital; Xijing Hospital; Second Affiliated Hospital, School of Medicine, Zhejiang University
Not yet recruiting
Pharmacokinetics of Intramuscular Adrenaline in Food--Allergic Teenagers

Condition: Anaphylaxis
Interventions: Combination Product: Epipen 0.3mg; Combination Product: Emerade 300mcg; Combination Product: Emerade 500mcg
Sponsor: Imperial College London
Recruiting
Effects of 5 Weeks Treatment With Dapagliflozin in Type 2 Diabetes Patients on How the Hormone Insulin Acts on Sugar Uptake in Muscles.

Conditions: Diabetes Mellitus, Type 2; Skeletal Muscle Insulin Sensitivity
Intervention: Drug: Dapagliflozin
Sponsor: AstraZeneca
Recruiting
8-Week Atopic Dermatitis (AD) Treatment Study

Condition: Atopic Dermatitis Eczema
Interventions: Drug: Investigational OTC Cream; Drug: 0.05% Desonide; Other: Placebo Cream
Sponsor: Procter and Gamble
Recruiting
CEGIR 7807: Validation of Online Cohort of EGID Patients Enrolled in RDCRN CEGIR Contact Registry

Condition: Eosinophilic Esophagitis
Intervention:
Sponsors: Children's Hospital Medical Center, Cincinnati; National Institute of Allergy and Infectious Diseases (NIAID); National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); Office of Rare Diseases (ORD); National Center for Advancing Translational Science (NCATS)
Not yet recruiting
Trial to Evaluate the Efficacy, Safety and Tolerability of BPaMZ in Drug-Sensitive (DS-TB) Adult Patients and Drug-Resistant (DR-TB) Adult Patients

Conditions: Tuberculosis, Pulmonary; Tuberculosis, Multidrug-Resistant; Tuberculosis, MDR; Tuberculosis; Drug-resistant Tuberculosis; Drug-Resistant Tuberculosis, Extremely
Interventions: Drug: Pretomanid; Drug: Bedaquiline; Drug: Moxifloxacin; Drug: Pyrazinamide; Drug: HRZE; Drug: HR
Sponsor: Global Alliance for TB Drug Development
Not yet recruiting
Role of Montelukast in Asthma and Allergic Rhinitis Patients

Condition: Asthma and Allergic Rhinitis
Intervention: Drug: Montelukast 10mg
Sponsor: Clinision
Not yet recruiting
Topical Application of BMX-010 in Subjects With Atopic Dermatitis and Plaque Psoriasis

Conditions: Psoriasis; Atopic Dermatitis
Interventions: Drug: BMX-010; Drug: Placebo
Sponsor: BioMimetix JV, LLC
Recruiting
Study on High-sensitivity Troponin 0h/1h for Rapid Diagnosis of Non-ST-segment Elevation Myocardial Infarction in the Chinese Population

Condition: Non-ST-segment Elevation Myocardial Infarction
Intervention:
Sponsors: Beijing Anzhen Hospital; Beckman Coulter, Inc.
Recruiting
Impedance Pneumography in Assessment of Asthma Control in Preschool Children

Conditions: Wheezing; Asthma in Children
Intervention:
Sponsors: HUS Skin and Allergy Hospital; Revenio Research; Mehiläinen
Recruiting
Effectiveness of Fluticasone Furoate/ Umeclidinium/ Vilanterol (FF/UMEC/VI) Using the Connected Inhaler System (CIS) as Compared With Fluticasone Proprionate/ Salmeterol (FP/SAL) Plus Tiotropium (TIO) in Inadequately Controlled Asthma

Condition: Asthma
Interventions: Drug: FF/UMEC/VI; Drug: FP/SAL; Drug: Tiotropium; Drug: Albuterol/salbutamol; Device: ELLIPTA DPI; Device: DISKUS DPI; Device: RESPIMAT inhaler; Device: Metered Dose Inhaler; Device: Connected Inhaler System
Sponsor: GlaxoSmithKline
Not yet recruiting
Effectiveness of PR013 Topical Ophthalmic Drops Compared to Vehicle for the Treatment of Allergic Conjunctivitis

Condition: Allergic Conjunctivitis
Interventions: Drug: PR013 (0.045%); Drug: PR013 (0.06%); Drug: Placebo
Sponsor: Realm Therapeutics, Inc.
Recruiting
A Study of AK002 in Patients With Atopic Keratoconjunctivitis, Vernal Keratoconjunctivitis, and Perennial Allergic Conjunctivitis

Conditions: Atopic Keratoconjunctivitis; Vernal Keratoconjunctivitis; Perennial Allergic Conjunctivitis
Intervention: Biological: AK002
Sponsor: Allakos, Inc.
Recruiting
Benjakul Extract and Loratadine for Treatment Allergic Rhinitis Patients

Condition: Allergic Rhinitis
Interventions: Drug: Benjakul Extract; Drug: Loratadine
Sponsor: Thammasat University
Recruiting
hsTnT in Patients Admitted to the ED With Atrial Fibrillation in the Era of NOACs - Heidelberg Registry of Atrial Fibrillation

Condition: Atrial Fibrillation
Intervention:
Sponsor: University Hospital Heidelberg
Recruiting
Efficacy of Family Programs for Improving Child and Family Health and Development

Condition: Behavior, Infant
Interventions: Behavioral: Control; Behavioral: Sensitivity Intervention; Behavioral: Couples' Intervention; Behavioral: Sensitivity and Couples' Intervention
Sponsors: University of Notre Dame; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting
Gait Adaptability: Tracking Locomotor Recovery After Incomplete Spinal Cord Injury

Conditions: Gait Disorders, Neurologic; Gait Disorder, Sensorimotor
Intervention: Behavioral: Standard locomotor therapy
Sponsor: University of Zurich
Recruiting
Biologic Mechanisms for Pain Variation After Physical Activity in Osteoarthritis

Conditions: Osteoarthritis, Knee; Pain; Physical Activity; Mitochondrial Pathology
Intervention: Behavioral: Walking
Sponsors: University of Maryland; National Institute of Nursing Research (NINR)
Not yet recruiting
EARLYEMOLLIENT - Feasibility of Early Emollient Use in Children With Atopic Eczema

Condition: Atopic Dermatitis
Intervention: Other: LIPIKAR BAUME AP+ emollient
Sponsors: University of Schleswig-Holstein; Technische Universität Dresden
Recruiting
Establishing the Collaborative Care Model of Traditional Chinese Medicine and Western Medicine-Pediatric Atopic Dermatitis

Condition: Atopic Dermatitis
Interventions: Other: TCM; Other: Western medicine
Sponsor: China Medical University Hospital
Recruiting
Efficacy and Safety of Lertal® as an add-on to Standard Therapy for Allergic Rhinoconjunctivitis in Pediatrics

Condition: Allergic Rhinoconjunctivitis
Interventions: Dietary Supplement: Lertal® + standard therapy; Other: Placebo + standard therapy
Sponsor: NTC srl
Recruiting
Observational Study of Characteristics, Treatment and Outcomes With Severe Asthma in the United States (CHRONICLE)

Condition: Asthma
Intervention:
Sponsors: AstraZeneca; Parexel; MedImmune LLC
Recruiting
Resistance Training and Cardiometabolic Health

Conditions: Insulin Sensitivity; Endothelial Dysfunction; Blood Pressure
Interventions: Other: High Load/Low Rep Resistance Training; Other: Low Load/High Rep Resistance Training
Sponsor: Arizona State University
Recruiting
Inhaled Steroids for Pediatric Asthma at Pediatric Emergency Medicine Discharge

Conditions: Asthma; Pediatric ALL
Intervention: Drug: budesonide, beclomethasone
Sponsor: New York City Health and Hospitals Corporation
Recruiting
Study of Chronic Rhinosinusitis Symptoms in Asthma Patients Undergoing Treatment With Reslizumab

Conditions: Chronic Rhinosinusitis (Diagnosis); Asthma; Nasal Polyps
Intervention: Drug: Reslizumab
Sponsor: University of Rochester
Recruiting
Study of Efficacy and Safety of Omalizumab in Severe Japanese Cedar Pollinosis Adult and Adolescent Patients

Condition: Seasonal Allergic Rhinitis
Interventions: Drug: Omalizumab; Drug: Placebo
Sponsor: Novartis Pharmaceuticals
Recruiting
Impact of [11C]-Methionine PET/MRI in the Detection of Pituitary Adenomas Secreting ACTH and Causing Cushing's Disease

Condition: Cushing's Disease
Intervention: Other: [11C]-Methionine PET/MRI
Sponsor: Hospices Civils de Lyon
Not yet recruiting
Basophil Activation Test to Diagnose Food Allergy

Conditions: Food Allergy; Food Allergy in Infants; Food Allergy in Children; Food Allergen Sensitisation; Milk Allergy; Egg Allergy; Nut Allergy
Intervention: Diagnostic Test: Oral food challenge
Sponsors: King's College London; Guy's and St Thomas' NHS Foundation Trust
Not yet recruiting
Luteinizing Hormone-releasing Hormone Analogue and Enzalutamide +/- Zoledronic Acid in Prostate Cancer Patients

Conditions: Prostate Cancer; Bone Metastases
Interventions: Drug: Zoledronic Acid; Drug: Enzalutamide
Sponsor: Azienda Ospedaliera Spedali Civili di Brescia
Recruiting
Vitamin D In the Prevention of Viral-induced Asthma in Preschoolers

Condition: Asthma
Interventions: Dietary Supplement: Vitamin D; Dietary Supplement: Placebo
Sponsors: St. Justine's Hospital; Canadian Institutes of Health Research (CIHR); EURO-PHARM International Canada inc.
Not yet recruiting
Impact of Statin Therapy on Muscle Mitochondrial Function and Aerobic Capacity

Condition: Mitochondrial Diseases
Interventions: Drug: Lipitor 20Mg Tablet; Drug: Lipitor 80Mg Tablet; Drug: Placebo Oral Tablet
Sponsors: University of Kansas Medical Center; National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Recruiting
MCT and Capsaicin Provocation Challenge in Diagnosis of Chronic Cough

Conditions: Cough; Cough Variant Asthma; Upper-Airway Cough Syndrome; GERD; Allergic Rhinitis
Intervention: Other: Cough variant asthma treatment
Sponsor: Medical University of Warsaw
Recruiting
Effect of Egg Consumption on Cardiometabolic Health in Prediabetic Subjects.

Condition: PreDiabetes
Interventions: Other: Egg based breakfast foods; Other: Non-egg based breakfast foods
Sponsor: Midwest Center for Metabolic and Cardiovascular Research
Recruiting
Gluten Related Disorders in Barrett's Esophagus

Conditions: Celiac Disease; Barrett Esophagus; Gluten Sensitivity; GERD
Intervention: Other: Gluten free diet
Sponsor: McMaster University
Not yet recruiting
Tralokinumab in Combination With Topical Corticosteroids for Moderate to Severe Atopic Dermatitis - ECZTRA 3 (ECZema TRAlokinumab Trial no. 3)

Condition: Atopic Dermatitis
Interventions: Drug: Tralokinumab; Drug: Placebo
Sponsor: LEO Pharma
Recruiting
BIOmarkers in Severe AsthMa Patients on Omalizumab Treatment

Condition: Severe Asthma
Intervention:
Sponsor: Medical University of Warsaw
Recruiting
A Novel Biologic Therapy for Perennial Allergic Rhinitis

Condition: Allergic Rhinitis
Interventions: Drug: Allergen Immunotherapy Extract; Drug: Allergen Immunotherapy Control
Sponsor: Johns Hopkins University
Recruiting
Disease Trajectories in Atopic Dermatitis and Psoriasis

Conditions: Atopic Dermatitis; Psoriasis
Intervention:
Sponsor: University of Schleswig-Holstein
Recruiting
Effects of SGLT2 Inhibition on Myocardial Insulin Sensitivity

Conditions: Type2 Diabetes Mellitus; Stable Coronary Artery Disease
Interventions: Drug: Dapagliflozin 10Mg Tab; Other: Placebo
Sponsor: Andrea Giaccari
Recruiting
Treatment of Alopecia Areata (AA) With Dupilumab in Patients With and Without Atopic Dermatitis (AD)

Condition: Alopecia Areata
Interventions: Drug: Dupilumab; Drug: Placebos
Sponsor: Icahn School of Medicine at Mount Sinai
Recruiting
Efficacy and Safety of PT001 to Placebo and Open-label Spiriva® Respimat® in Subjects With Persistant Asthma

Condition: Asthma
Interventions: Drug: GP MDI 28.8 μg; Drug: GP MDI 14.4 μg; Drug: GP MDI 7.2 μg; Drug: Placebo MDI; Drug: Spiriva Respimat 2.5 μg
Sponsor: Pearl Therapeutics, Inc.
Recruiting
Therapeutic Control of Aspirin-Exacerbated Respiratory Disease With Ifetroban

Conditions: Nasal Polyps; Asthma, Aspirin-Induced; Aspirin-exacerbated Respiratory Disease; Aspirin-Sensitive Asthma With Nasal Polyps
Interventions: Drug: Ifetroban; Drug: Placebo
Sponsor: Brigham and Women's Hospital
Not yet recruiting
Feasibility Trial in Men With Hormone Sensitive Oligometastatic Prostate Cancer

Condition: Hormone Sensitive Oligometastatic Prostate Cancer
Interventions: Procedure: Radical prostatectomy; Radiation: HDR (19Gy) or SBRT (35-40Gy)
Sponsor: Dr. Patrick Cheung
Recruiting
Anti-cytokine Signatures in Inflammatory Skin Disease

Conditions: Atopic Dermatitis; Psoriasis
Interventions: Drug: Ustekinumab; Drug: Infliximab; Drug: Secukinumab; Drug: Dupilumab
Sponsor: Prof. Dr. Stephan Weidinger
Recruiting
A Study of Crisaborole Ointment 2% in Children Aged 3-24 Months With Mild to Moderate Atopic Dermatitis

Condition: Atopic Dermatitis
Intervention: Drug: Crisaborole ointment 2%
Sponsor: Pfizer
Recruiting
Short Duration 6Fed Sponge For EoE Patients

Condition: Eosinophilic Esophagitis
Interventions: Device: Cytosponge; Other: Diet; Other: EEsAI Pro; Other: Likert Scoring Scale
Sponsor: Mayo Clinic
Not yet recruiting
Acupuncture Treatment for Knee Osteoarthritis With Sensitive Acupoints and Tender Points

Conditions: Acupuncture; Knee Osteoarthritis; Sensitive Acupoints; Tender Points
Intervention: Other: acupuncture
Sponsor: West China Hospital
Not yet recruiting
Efficacy and Safety of PR022 Topical Gel to Treat Mild-to-Moderate Atopic Dermatitis

Condition: Atopic Dermatitis
Intervention: Drug: PR022
Sponsor: Realm Therapeutics, Inc.
Recruiting
Discovery of Sirolimus Sensitive Biomarkers in Blood

Condition: Lymphangioleiomyomatosis
Intervention:
Sponsor: National Heart, Lung, and Blood Institute (NHLBI)
Recruiting
Nebulized Resveratrol Plus Carboxymethyl-β-Glucan for Reducing IL-5 in Children With Allergic Rhinitis

Condition: Allergic Rhinitis
Interventions: Drug: Resveratrol plus Carboxymethyl-β-Glucan; Drug: Placebo
Sponsor: Istituto di Biomedicina e Immunologia Molecolare Alberto Monroy
Recruiting
Study to Evaluate Tezepelumab in Adults & Adolescents With Severe Uncontrolled Asthma

Condition: Asthma
Interventions: Biological: Experimental: Tezepelumab; Other: Placebo
Sponsors: AstraZeneca; Amgen
Recruiting
Diagnostic Tools for Human African Trypanosomiasis Elimination and Clinical Trials: WP2 Passive Case Detection

Conditions: African Trypanosomiases; West African; Trypanosomiasis; Sleeping Sickness; West African; Trypanosoma Brucei Gambiense; Infection
Interventions: Diagnostic Test: Rapid diagnostic test (RDT); Diagnostic Test: Serological and molecular tests on DBS
Sponsors: Institut de Recherche pour le Developpement; Ministry of Public Health, Democratic Republic of the Congo; Ministry of Health, Guinea; Institut National de Sante Publique; Institut National de Recherche Biomédicale; CIRDES; Institute of Tropical Medicine, Belgium; University of Liverpool
Recruiting
Study to Evaluate Efficacy and Safety of PF-04965842 in Subjects Aged 12 Years And Older With Moderate to Severe Atopic Dermatitis

Condition: Dermatitis, Atopic
Interventions: Drug: PF-04965842 100 mg; Drug: PF-04965842 200 mg; Drug: Placebo
Sponsor: Pfizer
Recruiting
Metaplasticity in the Human Motor Cortex Experimental Design and Comparison of Motor Outcome Measure Sensitivity to Change

Condition: Healthy
Intervention: Device: rTMS
Sponsor: University of New Mexico
Recruiting
Sensitivity to Acute Cerebral Ischemia in Migrainers

Conditions: Ischemic Stroke; Migraine; Migraine With Aura
Intervention: Other: questionnaire ef-ID Migraine
Sponsor: University Hospital, Montpellier
Recruiting
A Study to Evaluate Conceptual Saturation of Evaluating Respiratory Symptoms (E-RS) in Subjects With Asthma

Condition: Asthma
Interventions: Other: Telephonic interviews; Other: E-RS: COPD; Other: Supplemental asthma items; Other: Daily diary; Other: Sociodemographic questionnaire; Other: Clinical questionnaire
Sponsors: GlaxoSmithKline; Evidera
Recruiting
Adding a Short Burst of Corticosteroid to the Conventional Treatment of H1 Antihistamines in Emergency Department.

Conditions: Urticaria; Allergy
Interventions: Drug: IV Dexamethasone; Drug: Oral prednisolone
Sponsor: Chulalongkorn University
Recruiting
Safety, Pharmacokinetics and Efficacy of Dupilumab in Patients ≥6 Months to <6 Years With Severe Atopic Dermatitis (Liberty AD PRESCHOOL)

Condition: Dermatitis, Atopic
Interventions: Drug: Dupilumab; Drug: Matching placebo
Sponsors: Regeneron Pharmaceuticals; Sanofi
Recruiting
Study to Investigate the Efficacy and Safety of Dupilumab Administered With Topical Corticosteroids (TCS) in Participants ≥6 to <12 Years With Severe Atopic Dermatitis (AD)

Condition: Dermatitis, Atopic
Interventions: Drug: Dupilumab; Drug: Matching Placebo; Other: Background Treatment: Topical Corticosteroids; Other: Background Treatment: Moisturizers
Sponsors: Regeneron Pharmaceuticals; Sanofi
Recruiting
CEGIR 7808: Use of Unsedated Transnasal Esophagoscopy (TNE) to Monitor Dietary Management of Eosinophilic Esophagitis in Children

Condition: Eosinophilic Esophagitis
Intervention: Other: Transnasal esophagoscopy
Sponsors: Children's Hospital Medical Center, Cincinnati; National Institute of Allergy and Infectious Diseases (NIAID); National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); Office of Rare Diseases (ORD); National Center for Advancing Translational Science (NCATS)
Recruiting
Effectiveness of Bioactiveglass Air Abrasion Versus Fluoride Varnish in Management of Dentin Hypersensitivity

Conditions: Hypersensitivity Dentin; Tooth Hypersensitivity
Interventions: Combination Product: Sylc; Combination Product: fluoride varnish (Bifluorid 10)
Sponsor: Cairo University
Not yet recruiting
Effect of Resistant Starch on Insulin Sensitivity and Beta Cell Function in Subjects With Prediabetes

Condition: Prediabetes
Interventions: Dietary Supplement: Resistant Starch; Dietary Supplement: Placebo
Sponsor: Hospital de Clinicas de Porto Alegre
Not yet recruiting
The Efficacy and Safety of Cettum for Perennial Allergic Rhinitis

Condition: Rhinitis, Allergic
Interventions: Procedure: Cettum; Procedure: Acupuncture
Sponsors: Eun Jung Kim; DongGuk University
Not yet recruiting
Effect of a Synbiotic "Probiotical® " in Asthma

Condition: Asthma
Interventions: Dietary Supplement: Probiotical®; Other: Placebo
Sponsors: University Hospital of Liege; European Union
Recruiting
Safer Food Allergy Management for Adolescents

Conditions: Food Allergy; Adherence, Medication
Interventions: Behavioral: Text Message Only; Behavioral: Text message + Incentive 1; Behavioral: Text message + Incentive 2
Sponsors: University of Pennsylvania; Children's Hospital of Philadelphia
Not yet recruiting
The Effect of Cetirizine on Bronchoconstriction

Conditions: Allergic Rhinitis; Asthma
Interventions: Drug: Cetirizine Hydrochloride 1 MG/ML; Drug: Placebo - Concentrate
Sponsor: New York City Health and Hospitals Corporation
Not yet recruiting
The Role of Ketamine as an Adjuvant Therapy for Children With Acute Status Asthmaticus

Condition: Status Asthmaticus
Intervention: Drug: Ketamine
Sponsor: Augusta University
Not yet recruiting
Study of Efficacy and Safety of Xolair® (Omalizumab) in Chinese Patients With Chronic Spontaneous Urticaria

Condition: Chronic Spontaneous Urticaria
Interventions: Drug: Omalizumab; Drug: Placebo
Sponsor: Novartis Pharmaceuticals
Recruiting
Anti-adhesive Effect and Safety of "Thermo-sensitive Adhesion Barrier (MEDICLORE)"

Conditions: Adhesion; Thyroidectomy
Intervention: Combination Product: MEDICLORE
Sponsors: Seoul National University Hospital; Daewoong Pharmaceutical Co. LTD.
Recruiting
Study of the Efficacy and Tolerance of Light Therapy in Sensitive Skin

Condition: Sensitive Skin
Intervention: Device: LED light
Sponsor: University Hospital, Brest
Not yet recruiting
Home Visits to Optimize Medical and Educational Success Among Sacramento Schoolchildren With Asthma

Conditions: Asthma; Chronic School Absenteeism
Interventions: Behavioral: Home Visit; Behavioral: Standard Care
Sponsor: University of California, Davis
Recruiting
A Study of Baricitinib (LY3009104) in Adults With Moderate to Severe Atopic Dermatitis

Condition: Atopic Dermatitis
Interventions: Drug: Baricitinib; Drug: Placebo
Sponsors: Eli Lilly and Company; Incyte Corporation
Recruiting
Study of Baricitinib (LY3009104) in Adults With Moderate to Severe Atopic Dermatitis

Condition: Atopic Dermatitis
Interventions: Drug: Baricitinib; Drug: Placebo
Sponsors: Eli Lilly and Company; Incyte Corporation
Recruiting
A Study of Long-term Baricitinib (LY3009104) Therapy in Atopic Dermatitis

Condition: Atopic Dermatitis
Interventions: Drug: Baricitinib; Drug: Placebo
Sponsors: Eli Lilly and Company; Incyte Corporation
Recruiting
Toward Self-management in ILD

Conditions: Interstitial Lung Disease; Idiopathic Pulmonary Fibrosis; Connective Tissue Related ILD; Chronic Hypersensitivity Pneumonitis; Fibrotic Lung Disease
Interventions: Behavioral: Focus groups; Behavioral: Semi-structured interviews
Sponsors: Kingston University; St. George's Hospital, London; University College London Hospitals
Recruiting
Changes in Intestinal Permeability 4 Hours After Gluten Challenge

Conditions: Celiac Disease; Wheat Hypersensitivity; Gluten Sensitivity; Gluten Enteropathy; Immune System and Related Disorders; Duodenal Diseases
Interventions: Dietary Supplement: Gluten; Dietary Supplement: Placebo
Sponsor: Mayo Clinic
Recruiting
Postoperative Hypersensitivity and Digital Radiographic Assessment of a Zinc Modified Versus a Conventional Glass Ionomer Cement in Deep Carious Lesion: Randomized Controlled Clinical Trial

Condition: Carious Dentin
Intervention: Procedure: Partial caries removel techniques
Sponsor: Cairo University
Not yet recruiting
The Effect of Benralizumab on Exercise-induced Bronchoconstriction

Condition: Asthma, Exercise-Induced
Intervention: Drug: Benralizumab
Sponsors: Louis-Philippe Boulet; AstraZeneca
Not yet recruiting
Improving Asthma Control Using Internet-based Cognitive-behavioral Treatment for Insomnia

Conditions: Asthma; Insomnia
Interventions: Behavioral: SHUTi; Behavioral: Emmi
Sponsors: University of Pittsburgh; National Heart, Lung, and Blood Institute (NHLBI)
Not yet recruiting
Information and Communication Technology (ICT)- Based Centralized Monitoring System of Asthma Control

Condition: Asthma
Intervention: Device: Feedback using ICT based monitoring system
Sponsors: Yeungnam University Hospital; Ministry of Trade, Industry & Energy, Republic of Korea; Korea Evaluation Institute of Industrial Technology; Daegu Metropolitan City, Korea; ICT Clinical Trial Coordination Center
Recruiting
Effects of Acute Intermittent Hypoxia on Sensory Function in Healthy Adults

Condition: Sensitivity
Intervention: Device: Hypoxicator
Sponsor: University of Florida
Recruiting
Misoprostol for Cervical Priming Before Office Hysteroscopy

Condition: Misoprostol Allergy
Intervention: Procedure: office hysteroscopy
Sponsor: Kasr El Aini Hospital
Recruiting
The Basophil Activation Test as a Diagnostic Tool in Pediatric Food Allergy

Condition: FOOD ALLERGY
Intervention: Diagnostic Test: The basophil activation test (BAT)
Sponsor: Assistance Publique Hopitaux De Marseille
Recruiting
Efficacy of Denosumab on Normal BMD in Women Receiving Adjuvant Aromatase Inhibitors for Early Breast Cancer

Condition: Breast Cancer
Intervention: Drug: Denosumab Injection
Sponsor: Kyoto Prefectural University of Medicine
Recruiting
Exploring Asthma Exacerbations in Mepolizumab Treated Patients

Condition: Asthma Brittle
Intervention:
Sponsors: Queen's University, Belfast; RASP (Refractory Asthma Stratification Programme); Medical Research Council; University of Oxford; University of Leicester; NHS Greater Glasgow and Clyde; Belfast Health and Social Care Trust
Recruiting
Integrative Omics Approach to Allergic Rhinitis

Condition: Allergic Rhinitis
Intervention:
Sponsors: Medical University of Graz; Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Not yet recruiting
Observation of Cough Variant Asthma Treated in Combination of Chanqin Granules.

Condition: Cough Variant Asthma
Intervention: Drug: Chanqin granules
Sponsor: Shanghai University of Traditional Chinese Medicine
Not yet recruiting
Translating an Efficacious Illness Management Intervention for Youth With Asthma

Condition: Asthma in Children
Interventions: Behavioral: Reach for Control; Behavioral: MATCH
Sponsors: Wayne State University; National Heart, Lung, and Blood Institute (NHLBI)
Not yet recruiting
CEGIR 7809: Effect of Elemental Diet on Adult Patients With Eosinophilic Gastroenteritis

Condition: Eosinophilic Gastroenteritis
Intervention: Other: elemental diet therapy
Sponsors: Children's Hospital Medical Center, Cincinnati; National Institute of Allergy and Infectious Diseases (NIAID); National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); Office of Rare Diseases (ORD); National Center for Advancing Translational Science (NCATS)
Recruiting
Macular Hole Surgery With Temporal Inverted Internal Limiting Membrane Flap (MARTIAL)

Condition: Macula Hole
Intervention: Procedure: Macular hole surgery
Sponsor: Central Hospital, Nancy, France
Not yet recruiting
Asparaginase Encapsulated in Erythrocytes for Patients With ALL and Hypersensitivity to PEG-asparaginase

Condition: Acute Lymphoblastic Leukemia
Intervention: Drug: GRASPA
Sponsors: Birgitte Klug Albertsen; ERYtech Pharma
Recruiting
Asthma, Smoking, Emotional Deficits

Conditions: Asthma; Emotional Disorder; Alexithymia
Intervention: Other: Interview and tests of drawing.
Sponsor: Hospices Civils de Lyon
Not yet recruiting
Changes in Esophageal Distensibility With Proton Pump Inhibitors in Patients With Esophageal Eosinophilia: A Pilot Study

Condition: Eosinophilic Esophagitis
Intervention: Diagnostic Test: endoflip
Sponsor: Indiana University
Recruiting
Depression & Insulin Sensitivity in Adolescents

Conditions: Type2 Diabetes; Type 2 Diabetes Mellitus; Insulin Sensitivity; Insulin Resistance; Depression; Adolescent Obesity
Interventions: Behavioral: Cognitive-behavioral therapy group; Behavioral: Health education group
Sponsors: Colorado State University; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD); National Center for Advancing Translational Science (NCATS); Children's Hospital Colorado
Recruiting
Cognitive, Emotional, and Neural Responses to Acute Inflammation

Condition: Healthy
Interventions: Biological: Typhoid Vi Polysaccharide Vaccine; Biological: Placebo
Sponsors: University of California, San Francisco; National Institute of Mental Health (NIMH)
Not yet recruiting
Validation of Progranulin as a Biomarker for Sepsis

Condition: Sepsis
Intervention:
Sponsors: Ludwig-Maximilians - University of Munich; City of Munich
Recruiting
Use of Esophageal String Test to Understand Symptoms, Inflammation, and Function in Eosinophilic Esophagitis

Condition: Eosinophilic Esophagitis
Intervention: Device: Esophageal String Test (EST)
Sponsors: University of Colorado, Denver; Children's Hospital of Philadelphia; Children's Hospital Colorado
Not yet recruiting
Effects of Compression Stockings in Asthma Symptoms at Night

Condition: Asthma
Interventions: Other: Compression Stockings; Other: Control
Sponsor: University Health Network, Toronto
Recruiting
A Study to Measure the Efficacy of a Toothpaste on Dentinal Hypersensitivity

Condition: Dentin Sensitivity
Interventions: Device: CSSP Toothpaste; Device: Fluoride Toothpaste
Sponsors: Unilever R&D; University of Bristol
Recruiting
Predictive Role of New Biomarkers for Hypersensitive Patients to Radiation in Breast Cancer (BIORISE)

Condition: Breast Cancer
Intervention: Biological: Blood sample
Sponsor: Institut du Cancer de Montpellier - Val d'Aurelle
Recruiting
Study to Explore the Pharmacokinetics and Pharmacodynamics of Epinephrine in Healthy Male and Female Subjects With Different Skin to Muscle Depth (STMD)

Condition: Anaphylaxis
Interventions: Device: Part 1; Device: Part 2 Group 1; Drug: Part 2 group 2; Device: Part 2 group 3; Device: Part 2 Group 4
Sponsor: Bausch & Lomb Incorporated
Recruiting
Efficacy of Antihistamine Dosing-up and add-on Treatment With H2-receptor Antagonist

Condition: Chronic Urticaria
Intervention:
Sponsor: Ajou University School of Medicine
Recruiting
Validation of the BREATHE Asthma Intervention Trial

Condition: Asthma
Interventions: Behavioral: BREATHE Intervention; Behavioral: Control Intervention
Sponsor: Columbia University
Recruiting
A Study to Assess Jia Wei Yang He Formula as a Plus Therapy in the Treatment of Persistent Asthma

Condition: Bronchial Asthma
Interventions: Drug: Jia Wei Yang He granule; Drug: Jia Wei Yang He granule Placebo
Sponsors: Shanghai University of Traditional Chinese Medicine; Fudan University
Recruiting
COMPLliancE and qualiTy of lifE in Asthma

Conditions: Asthma; Compliance, Patient; Quality of Life
Intervention:
Sponsor: Elpen Pharmaceutical Co. Inc.
Recruiting
Study to Assess the Efficacy and Safety of CJM112 in Patients With Inadequately Controlled Severe Asthma

Condition: Asthma
Interventions: Drug: CJM112; Other: Placebo to CJM112
Sponsor: Novartis Pharmaceuticals
Recruiting
Tailored PCA Based on Preoperative Pain Sensitivity

Condition: Analgesia, Patient-Controlled
Interventions: Other: Tailored regimen of IV PCA according to pain sensitivity; Other: Regimen of IV PCA without considering pain sensitivity
Sponsor: Seoul National University Hospital
Recruiting
RVA Breathes: A Richmond City Collaboration to Reduce Pediatric Asthma Disparities

Condition: Asthma
Interventions: Behavioral: School; Behavioral: Asthma education; Behavioral: Home environmental remediation; Behavioral: Informational mail
Sponsors: Virginia Commonwealth University; National Heart, Lung, and Blood Institute (NHLBI)
Not yet recruiting
Predictive Value of Drug Sensitivity Testing Tumorspheres From Patients With Metastatic Colorectal Cancer

Condition: Colorectal Cancer Metastatic
Intervention: Drug: Based on sensitivity analysis
Sponsor: Vejle Hospital
Recruiting
Non-invasive Ventilation vs. Standard Therapy for Children Hospitalized With an Acute Exacerbation of Asthma

Conditions: Asthma Acute; Asthma in Children
Interventions: Device: BiPAP; Device: CPAP; Drug: Ipratropium; Drug: Magnesium Sulfate; Drug: Aminophylline; Drug: Standard steroid dose, hourly salbutamol, oxygen as needed
Sponsors: University of British Columbia; Post Graduate Institute of Medical Education and Research, Chandigarh
Not yet recruiting
Hypoallergenicity Evaluation of a New Extensively Hydrolyzed Formula

Condition: Cow Milk Allergy
Interventions: Other: Test extensively hydrolyzed formula; Other: Control extensively hydrolyzed formula
Sponsor: Nestlé
Recruiting
Pilot of Lifestyle and Asthma Intervention

Condition: Asthma
Intervention: Behavioral: Weight loss intervention
Sponsors: Johns Hopkins University; American Lung Association; National Heart, Lung, and Blood Institute (NHLBI); University of Vermont; University of Arizona
Recruiting
REPLACE: Can Exercise Replace Inhaled Corticosteroid Treatment in Asthma? A RCT

Condition: Asthma
Intervention: Behavioral: High Intensity Interval Training
Sponsor: Bispebjerg Hospital
Recruiting
A Trial of Mepolizumab Adjunctive Therapy for the Prevention of Asthma Exacerbations in Urban Children

Condition: Asthma
Interventions: Biological: Mepolizumab; Drug: Placebo
Sponsors: National Institute of Allergy and Infectious Diseases (NIAID); Inner-City Asthma Consortium; GlaxoSmithKline
Recruiting
Immunogenetic Profiling of Dupilumab for the Treatment of Atopic Dermatitis

Conditions: Atopic Dermatitis; Atopic Dermatitis Eczema
Intervention: Drug: Dupilumab
Sponsors: University of California, San Francisco; Regeneron Pharmaceuticals
Not yet recruiting
Natural History of Eosinophilic Esophagitis

Condition: Eosinophilic Esophagitis
Interventions: Diagnostic Test: Barium Esophagram; Device: EsophaCap; Diagnostic Test: Physical Examination and Questionnaires
Sponsor: Mayo Clinic
Recruiting
TRACK: Validation of the Portuguese Version

Conditions: Asthma; Respiratory Disease
Intervention: Other: TRACK questionnaire
Sponsors: Federal University of São Paulo; AstraZeneca
Recruiting
Study to Assess the Safety, Tolerability, and Preliminary Efficacy of B244 in Healthy Volunteers and Subjects With Seasonal Allergic Rhinitis

Conditions: Allergic Rhinitis; Allergic Rhinitis Due to Grass Pollen; Healthy Volunteers
Interventions: Biological: B244 suspension; Biological: Vehicle
Sponsors: AOBiome LLC; Orange County Research Center; Integrium
Recruiting
Changes in Sensitivity, Taste and Smell in Stroke Patients

Conditions: Dysphagia; Stroke
Interventions: Diagnostic Test: FEES (flexible endoscopic evaluation of swallowing); Other: Sensitivity threshold; Diagnostic Test: Taste-/smell-test; Diagnostic Test: Neuropsychological testing
Sponsor: University of Giessen
Recruiting
First Time in Human (FTIH) Study to Evaluate Safety, Tolerability, Immunogenicity, Pharmacokinetics (PK) and Pharmacodynamics (PD) of GSK3511294 Administered Subcutaneously (SC) in Subjects With Mild to Moderate Asthma

Condition: Asthma
Interventions: Drug: GSK3511294; Drug: Placebo; Drug: Salbutamol/albuterol
Sponsor: GlaxoSmithKline
Recruiting
LEAn Body Mass Normalization of OXaliplatin Based Chemotherapy

Condition: Stage III Colon Cancer
Interventions: Drug: Oxaliplatin; Drug: Oxaliplatin LBM
Sponsor: Institut du Cancer de Montpellier - Val d'Aurelle
Recruiting
Short and Mid-term Repeatability of Active Anterior Rhinomanometry (AAR) Measurements in Paediatric Age

Conditions: Rhinitis; Rhinitis, Allergic; Rhinitis, Allergic, Seasonal; Rhinitis, Allergic, Perennial
Intervention:
Sponsor: Istituto di Biomedicina e Immunologia Molecolare Alberto Monroy
Recruiting
Assessment of Cow's Milk-related Symptom Scoring Awareness Tool in Young Turkish Children

Condition: Cow Milk Allergy
Intervention:
Sponsor: Ankara University
Recruiting
Evaluation of Bowel Sensitivity Threshold in IBS Patients Versus in Healthy Controls Using the Novel Rapid Barostat Bag

Conditions: Irritable Bowel Syndrome; Visceral Hypersensitivity
Interventions: Device: Rapid Barostat Bag; Other: IBS severity scoring system questionnaire (IBS-SSS); Other: HAD scale questionnaire
Sponsor: Queen's University
Recruiting
ToAST:Investigating the Effect of Bronchial Thermoplasty on Cough in Patients With Severe Asthma

Condition: Asthma Chronic, Cough
Intervention: Other: Inhaled capsaicin cough challenge
Sponsor: National Health Service, United Kingdom
Recruiting
Effect of Nesiritide Infusion on Insulin Sensitivity in Healthy Obese Insulin Resistant Subjects

Condition: Diabetes
Interventions: Drug: Continous IV infusion of Nesiritide; Drug: Hyperinsulinemic euglycemic clamp; Drug: Placebo
Sponsor: Translational Research Institute for Metabolism and Diabetes, Florida
Recruiting
General Risk Factors and Inflammatory Determinants in Older Patients With Asthma

Conditions: Asthma; Late-Onset Asthma; Childhood Asthma
Interventions: Procedure: Sputum induction; Procedure: Blood sample
Sponsor: Gert Jan Braunstahl / Gerdien Tramper
Recruiting
Pressure Sensitive Mats for Patient Monitoring in the NICU

Conditions: Apnea; Respiration Disorder
Intervention: Device: Pressure sensitive mat
Sponsors: Children's Hospital of Eastern Ontario; NSERC Collaborative Research and Development
Recruiting
A Trial of Androgen Deprivation, Docetaxel, and Enzalutamide for Metastatic Prostate Cancer

Conditions: Prostate Cancer; Prostate Adenocarcinoma
Intervention: Drug: ADT+Docetaxel+Enzalutamide
Sponsors: Earle Burgess; Astellas Pharma Inc; Medivation, Inc.
Recruiting
Pilot Study: Characterization of the Immune Phenotype of Patients Allergic to Wasp Venom or Penicillin

Condition: Allergy
Intervention: Other: Human biological samples
Sponsor: Institut Pasteur
Recruiting
Bispectral Index (BIS) for Classification of Procalcitonin (PCT) Sepsis Grades in Critically Ill Patients With Sepsis

Condition: Sepsis, Severe
Intervention: Other: no intervention
Sponsors: Medical University of Graz; Dalian Medical University
Recruiting
RAPP-children, Rhinitis & Asthma in Patient Perspective: Development and Validation of a Questionnaire for Quality of Life Evaluation in Children With Asthma and Allergic Rhinitis

Conditions: Asthma; Allergic Rhinitis
Intervention:
Sponsor: Istituto di Biomedicina e Immunologia Molecolare Alberto Monroy
Recruiting
Pragmatic RCT of High-dose Oral Montelukast for Moderate and Severe Pediatric Acute Asthma Exacerbations

Conditions: Asthma; Status; Asthma in Children; Asthma Acute; Asthma Attack; Acute Asthma Exacerbation
Intervention: Drug: Montelukast Oral Granules
Sponsor: Vanderbilt University Medical Center
Not yet recruiting
VALIDATION OF THE CHAPTER "ALLERGIES AND HYPERSENSITIVITY" OF THE INTERNATIONAL DISEASE CLASSIFICATION (CIM)

Condition: ALLERGIC OR HYPERSENSITIVITY
Intervention: Other: No intervention: analysis of health data from patients with
Sponsors: University Hospital, Montpellier; AstraZeneca
Recruiting
BRS and Outcomes in Cardiothoracic Surgery

Conditions: Pain, Postoperative; Atrial Fibrillation; Cognitive Dysfunction
Intervention:
Sponsor: Duke University
Recruiting
Protocol Establishment for the Prevention of Lamotrigine-induced Skin Rash in Epilepsy Patients

Condition: Lamotrigine Allergy
Intervention: Drug: Lamotrigine
Sponsor: Seoul National University Hospital
Recruiting
Clinical Characteristics of Asthma and COPD Overlap for Patients With Asthma and COPD in Hong Kong

Conditions: COPD; Asthma
Intervention: Other: No intervention
Sponsor: Chinese University of Hong Kong
Recruiting
DragONE Study: Acquisition and Maintenance of Paediatric Asthma Control: Usual Care vs Innovative Devices

Condition: Asthma
Interventions: Device: DragONE; Device: SmartOne
Sponsor: Istituto di Biomedicina e Immunologia Molecolare Alberto Monroy
Recruiting
Post-marketing Safety Monitoring Program of Fluticasone Propionate (FP) in Chinese Subjects With Asthma Aged 1 to <4 Years

Condition: Asthma
Intervention: Drug: Fluticasone propionate
Sponsor: GlaxoSmithKline
Recruiting
Effect of Empagliflozin Versus Placebo on Brain Insulin Sensitivity in Patients With Prediabetes

Conditions: PreDiabetes; Body Weight
Interventions: Drug: Empagliflozin 25mg; Drug: Placebo Oral Tablet
Sponsor: University Hospital Tuebingen
Recruiting
Post-Marketing Surveillance Study of OTEZLA

Condition: Psoriasis
Intervention:
Sponsor: Celgene
Recruiting
Flu Vaccine Response in Patients on Biologic Therapies

Conditions: Rheumatologic Disorder; Inflammatory Bowel Diseases; Immune Complex Diseases
Intervention: Biological: Influenza vaccine
Sponsors: Stony Brook University; University of North Carolina, Chapel Hill
Recruiting
Development of Diagnostic Pathway for Teicoplanin Allergy

Condition: Hypersensitivity
Intervention: Procedure: Blood test, skin testing and challenge testing.
Sponsor: The Leeds Teaching Hospitals NHS Trust
Recruiting
The Study of Bacteriology and Pathogen Drug Sensitivity of Chronic Dacryocystitis

Conditions: Dacryocystitis; Bacteriology
Intervention: Diagnostic Test: bacterial culture and analysis
Sponsor: Sun Yat-sen University
Recruiting
Carnitine Supplementation in Type 2 Diabetic Patients

Condition: Glucose Intolerance
Intervention: Drug: Carnitene (L-Carnitine or Levocarnitine)
Sponsor: Maastricht University Medical Center
Recruiting
Comparison in Marginal Adaptation Between Conventional and Gull Wing Preparation in Laminates Veneers

Condition: Teeth Sensitivity
Interventions: Procedure: gull wing preparation of laminates veneers; Procedure: conventional preparation of laminates veneers
Sponsor: Cairo University
Not yet recruiting
Methicillin-sensitive and Methicillin-resistant Staphylococcus Aureus (MSSA/MRSA) - Point-of-care-testing (POCT) in Clinical Decision Making

Condition: Staphylococcus Aureus
Intervention: Other: Decolonization by nasal Octinidin treatment and skin washings
Sponsor: Charite University, Berlin, Germany
Recruiting
Study of Nab-paclitaxel in Sensitive and Refractory Relapsed SCLC

Condition: Small Cell Lung Cancer
Intervention: Drug: Nabpaclitaxel
Sponsors: Gruppo Oncologico Italiano di Ricerca Clinica; Temas srl; Clirest s.r.l.; Mipharm S.p.A.; Istituto Toscano Tumori - Centro per il Coordinamento delle Sperimentazioni Cliniche
Recruiting
Safety and Efficacy of FURESTEM-AD Inj. in Patients With Moderate to Severe Chronic Atopic Dermatitis(AD)

Condition: Atopic Dermatitis
Interventions: Biological: FURESTEM-AD Inj.; Other: Placebo
Sponsor: Kang Stem Biotech Co., Ltd.
Recruiting
Softened Water for Eczema Prevention Pilot Trial

Condition: Atopic Eczema
Intervention: Device: Domestic ion-exchange water softener
Sponsors: King's College London; Guy's and St Thomas' NHS Foundation Trust; University of Nottingham; University of Sheffield; Imperial College London; University of Amsterdam; University of Dundee
Recruiting
Role of Thymus-And Activation-Regulated Chemokine (TARC) In Diagnosis Of Allergic Bronchopulmonary Aspergillosis

Condition: Thymus and Activation Regulated Chemokine
Intervention:
Sponsor: Assiut University
Not yet recruiting
physicAl aCtiviTy In minOrity womeN With Asthma Intervention

Condition: Asthma
Interventions: Behavioral: ACTION Intervention; Other: Enhanced usual care
Sponsor: University of Illinois at Chicago
Not yet recruiting
Diagnostic Value of MRI for Allergic Broncho-Pulmonary Aspergilloses

Condition: Allergic Bronchopulmonary Aspergilloses
Interventions: Device: MRI; Device: CT scan (standard reference)
Sponsor: University Hospital, Bordeaux
Not yet recruiting
COmparisoN of High-sensitivity Cardiac TRoponin I and T ASsays Trial

Conditions: Acute Myocardial Infarction; Acute Coronary Syndrome
Intervention: Diagnostic Test: Cardiac troponin testing
Sponsors: Minneapolis Medical Research Foundation; Abbott Diagnostics Division; Hennepin County Medical Center, Minneapolis
Recruiting
Site and Mechanism(s) of Expiratory Airflow Limitation in COPD, Emphysema and Asthma-COPD Overlap

Conditions: COPD, Emphysema, Asthma COPD Overlap; Emphysema
Intervention: Other: As above: diagnosis: COPD, Emphysema, Asthma-COPD Overlap
Sponsor: Gelb, Arthur F., M.D.
Recruiting
Collaborative Self-Management Support in Chronic Conditions - Qualitative Study

Conditions: Asthma; Breast Cancer; Stroke
Intervention: Other: Semi-structured interviews
Sponsor: Hospices Civils de Lyon
Not yet recruiting
Pneumococcal Vaccines in Patients With Asthma

Condition: Asthma
Interventions: Biological: PCV13; Biological: PPSV23
Sponsor: Mayo Clinic
Recruiting
Perceptual-Cognitive Training After a Mild Traumatic Brain Injury: Towards a Sensitive Marker for Recovery

Conditions: Brain Concussion; Post-Concussion Symptoms; Concussion
Interventions: Other: 3D-MOT Neurotracker; Other: Visual Attention Intervention
Sponsors: McGill University Health Center; Merck Sharp & Dohme Corp.
Recruiting
PEARLS Intervention

Condition: Deafness, Bilateral
Interventions: Behavioral: Parent-Child Early Approaches to Raising Language Skills; Other: Standard Care Speech therapy
Sponsors: University of Miami; National Institute on Deafness and Other Communication Disorders (NIDCD)
Recruiting
Pharmacodynamics, Safety, Tolerability, and Pharmacokinetics of Two Orally Inhaled Indacaterol Salts in Adult Subjects With Asthma.

Condition: Asthma
Interventions: Drug: Indacaterol maleate; Drug: Indacaterol acetate; Drug: Placebo
Sponsor: Novartis Pharmaceuticals
Not yet recruiting
Can Vitamin D Treatment Help Treat Moderate to Severe Atopic Dermatitis in Young Children? The D-Vex Pilot Study

Condition: Atopic Dermatitis
Interventions: Drug: Stoss vitamin D; Drug: Daily vitamin D; Drug: Stoss placebo; Drug: Daily placebo
Sponsor: Murdoch Childrens Research Institute
Recruiting
A Pharmacokinetic Study of INCB018424 Phosphate Cream in Pediatric Subjects With Atopic Dermatitis

Condition: Atopic Dermatitis
Intervention: Drug: INCB018424 phosphate cream
Sponsor: Incyte Corporation
Recruiting
Determinants of Liver Fat Composition

Conditions: Fatty Liver, Nonalcoholic; Insulin Sensitivity
Intervention:
Sponsors: Maastricht University Medical Center; Unilever R&D
Recruiting
Eucrisa for Atopic Dermatitis

Condition: Mild to Moderate Atopic Dermatitis
Intervention: Behavioral: Online Treatment response
Sponsor: Wake Forest University Health Sciences
Recruiting
Safety and Efficacy Study of Fluticasone Furoate/Vilanterol (FF/VI) Fixed Dose Combination (FDC) Compared to FF Alone in Subjects With Asthma

Condition: Asthma
Interventions: Drug: FF/VI via ELLIPTA DPI; Drug: FF via ELLIPTA DPI
Sponsor: GlaxoSmithKline
Recruiting
Lidocaine for Oxaliplatin-induced Neuropathy

Conditions: Neuropathy, Painful; Chemotherapy-induced Peripheral Neuropathy; Colorectal Cancer
Interventions: Drug: Lidocaine Hydrochloride; Drug: Placebo; Drug: FOLFOX regimen
Sponsor: Washington University School of Medicine
Recruiting
The Juice Study: Sensitivity of Skin Carotenoid Status to Detect Change in Intake

Condition: Overweight
Interventions: Other: High dose vegetable juice; Other: Medium dose vegetable juice; Other: Low dose vegetable juice; Other: Control bottled water
Sponsor: USDA Grand Forks Human Nutrition Research Center
Recruiting
Lean Beef Consumption and Insulin Sensitivity in Men and Women With Risk Factors for Diabetes

Conditions: Metabolic Syndrome; PreDiabetes
Interventions: Other: USDA Style Diet; Other: Lean Beef Diet
Sponsors: Midwest Center for Metabolic and Cardiovascular Research; National Cattlemen's Beef Association
Recruiting
Continuation Study With Budesonide Oral Suspension (BOS) for Adolescent and Adult Subjects With Eosinophilic Esophagitis (EoE)

Condition: Eosinophilic Esophagitis (EoE)
Intervention: Drug: Budesonide oral suspension
Sponsor: Shire
Recruiting
A Study to Determine the Clinical Characteristics, Comorbidities, Treatment Status and Exacerbations of Asthma Patients

Condition: Asthma
Intervention: Other: asthmatic exacerbation
Sponsor: Chinese University of Hong Kong
Recruiting
Multi OIT to Test Immune Markers After Minimum Maintenance Dose

Condition: Food Allergy
Interventions: Drug: Omalizumab; Drug: Food Flour Allergens
Sponsors: Kari Christine Nadeau; University of California, Los Angeles
Recruiting
Comparison of Different Desensitizers in Reducing Dentinal Hypersensitivity

Condition: Dentine Hypersensitivity
Interventions: Drug: 5% fluoride varnish; Drug: 8% arginine containing paste; Drug: Self-adhesive resin
Sponsor: Aga Khan University
Recruiting
Clinical Characteristics, Treatment and Prognosis of Chest Tightness Variant Asthma

Conditions: Asthma; Chest Syndrome; Clinical Anxiety; Clinical Depression; Lung Function; Quality of Life; Eosinophilia; Nitric Oxide; Airway Responsiveness; Induced Sputum
Intervention: Drug: Treat patient according to Global Initiative for Asthma (GINA) guideline
Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University
Recruiting
Study of BCX7353 as a Treatment for Attacks of Hereditary Angioedema

Condition: Hereditary Angioedema (HAE)
Interventions: Drug: BCX7353; Drug: Placebo
Sponsor: BioCryst Pharmaceuticals
Recruiting
Phase IIb Study of Evobrutinib in Subjects With Rheumatoid Arthritis

Condition: Rheumatoid Arthritis
Interventions: Drug: Evobrutinib; Drug: Placebo; Drug: Methotrexate
Sponsors: EMD Serono Research & Development Institute, Inc.; Merck KGaA
Recruiting
Study to Determine Safety and Efficacy of B244 in Subjects With Mild to Moderate Atopic Dermatitis

Condition: Atopic Dermatitis Eczema
Interventions: Biological: B244; Biological: Vehicle
Sponsors: AOBiome LLC; Veristat, Inc.
Recruiting
Effect of Isocaloric Ultra Processed Versus Unprocessed Diets on Insulin Sensitivity

Condition: Obesity
Intervention:
Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting
Text Based Mobile Technology and Weight Loss

Condition: Obesity
Interventions: Behavioral: CareMessage™; Behavioral: Control Condition
Sponsor: Washington University School of Medicine
Not yet recruiting
Sensitivity of Basic Taste in Elderly

Condition: Taste Disorders
Intervention:
Sponsors: Hospital Israelita Albert Einstein; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior.
Recruiting
Patterns of Neurocircuitry Activation In Severe Asthma

Condition: Lung Diseases
Interventions: Other: functional Magnetic Resonance Imaging (research grade); Other: Cognitive Function Testing (non-diagnostic); Other: Asthma and Psychological Questionnaires (non-diagnostic)
Sponsors: University of Wisconsin, Madison; National Institutes of Health (NIH); National Heart, Lung, and Blood Institute (NHLBI)
Recruiting
The Effect of Chlorpromazine on Esophageal Sensitivity in Healthy Volunteers.

Condition: Esophageal Reflux
Interventions: Drug: Chlorpromazine; Device: Multimodal stimulation probe; Drug: Placebo - Concentrate
Sponsor: Universitaire Ziekenhuizen Leuven
Not yet recruiting
Molecular Mechanisms of Resistance and Sensitivity to Palbociclib Re-challenge in ER+ mBC

Condition: Metastatic Breast Cancer
Interventions: Drug: Palbociclib; Drug: Endocrine therapy (non IMP)
Sponsor: MedSIR
Recruiting
Clinical Study on Treatment of Chronic Persistent Bronchial Asthma

Condition: Bronchial Asthma
Interventions: Drug: Ke Chuan Liu Wei Granule; Drug: Yang He Ping Chuan Granule; Other: Ke Chuan Liu Wei Granule placebo; Other: Yang He Ping Chuan Granule placebo
Sponsors: Shanghai University of Traditional Chinese Medicine; Longhua Hospital
Not yet recruiting
Intraperitoneal Delivery of Adaptive Natural Killer (NK) Cells (FATE-NK100) With Intraperitoneal Int

Conditions: Epithelial Ovarian Cancer; Fallopian Tube Cancer; Primary Peritoneal Cancer
Interventions: Biological: FATE-NK100; Drug: Interleukin-2
Sponsor: Masonic Cancer Center, University of Minnesota
Recruiting
Novel Behavioral Intervention to Enhance Social Connections in Anxiety and Depression

Conditions: Anxiety Disorders and Symptoms; Depression
Interventions: Behavioral: Social Approach Training (5 sessions); Behavioral: Social Approach Training (10 sessions)
Sponsor: University of California, San Diego
Recruiting
A 12-week, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Assess the Efficacy and Safety of QAW039 When Added to Standard-of-care Asthma Therapy in Patients With Uncontrolled Asthma.

Condition: Asthma
Interventions: Drug: QAW039; Drug: Placebo
Sponsor: Novartis Pharmaceuticals
Not yet recruiting
Mechanisms of Anaphylaxis

Conditions: Anaphylaxis; Allergy; Transfusion Reaction; Febrile Transfusion Reaction
Intervention: Diagnostic Test: Biomarkers (platelet activating factor [PAF], anaphylatoxins) and basophil activation test (BAT)
Sponsor: Haukeland University Hospital
Recruiting
Confirmatory Efficacy Trial of a Gluten-Free Diet in a Subgroup of Persons With Schizophrenia Who Have High Levels of IgG Anti-Gliadin Antibodies (AGA IG)

Conditions: Schizophrenia; Gluten Sensitivity; Schizo Affective Disorder
Interventions: Other: Gluten Flour in Protein Shake; Other: Rice Flour in Protein Shake
Sponsor: University of Maryland
Recruiting
HIRREM in Military Personnel

Condition: Stress Disorders, Post-Traumatic
Intervention: Device: HIRREM
Sponsors: Wake Forest University Health Sciences; Brain State Technologies, LLC
Recruiting
Systematic Screening for Comorbid Psychological Conditions in Cardiac ACSC Patients With Multimorbidity in the ED

Conditions: Depression; Anxiety; Somatoform Disorders; Alcohol Abuse
Intervention:
Sponsors: Charite University, Berlin, Germany; German Federal Ministry of Education and Research
Recruiting
Exercise Testing in Peripheral Artery Disease Patients

Condition: Peripheral Artery Disease
Intervention: Other: Data collected
Sponsor: Rennes University Hospital
Recruiting
Topical Antibiotic Prophylaxis for Eyelids

Conditions: Antibiotic Side Effect; Eyelid; Wound; Eyelid Diseases; Surgical Wound Infection; Surgical Wound, Recent; Surgical Incision; Skin Cancer Face; Antibiotic Allergy; Surgical Site Infection
Interventions: Drug: Topical Anti-Infective Product; Drug: Topical Ointment
Sponsor: University of California, San Francisco
Recruiting
The Clinical Study on Pseudo-allergic Reaction to Anesthetic Drugs During General Anesthesia

Condition: General Anesthetic Drug Allergy
Intervention:
Sponsor: Central South University
Recruiting
Comparison of QoL Between Trabectedin/PLD and Standard Platinum-based Therapy in Patients With Platinum Sensitive Recurrent Ovarian Cancer

Conditions: Quality of Life; Ovarian Cancer; Recurrent Ovarian Carcinoma
Intervention: Other: no intervention - observational study
Sponsor: North Eastern Germany Society of Gynaecologic Oncology
Recruiting
Exploratory Study of Drug Sensitivity Prediction Software (IRCR-DReSS) With Patient-derived Tumor Cells of Metastatic Gastric Cancer

Condition: Stomach Neoplasms
Interventions: Drug: Sunitinib; Drug: Gefitinib; Drug: Imatinib
Sponsor: Samsung Medical Center
Recruiting
Study of Efficacy and Safety of QAW039 When Added to Standard-of-care Asthma Therapy in Patients With Uncontrolled Asthma

Condition: Asthma
Interventions: Drug: QAW039; Drug: Placebo
Sponsor: Novartis Pharmaceuticals
Not yet recruiting
Improvement of Foodallergy Diagnostic in Gastrointestinal Tract

Condition: Food Allergy
Intervention: Diagnostic Test: Cytobrush
Sponsor: University of Erlangen-Nürnberg Medical School
Recruiting
Interrelation Between Bronchial Asthma and Smoking

Condition: Bronchial Asthma
Intervention: Drug: Corticosteroid
Sponsor: Assiut University
Not yet recruiting
Culture-sensitive Emotion Regulation Group Therapy for Traumatized Refugees

Condition: Trauma
Intervention: Behavioral: Skills training of Affect-Regulation - A culture-sensitive approach: STARK
Sponsors: Ludwig-Maximilians - University of Munich; REFUGIO Munich
Recruiting
Inhibition of Anaphylaxis by Ibrutinib

Conditions: Food Allergy; Anaphylaxis Food
Intervention: Drug: Ibrutinib
Sponsors: Ann & Robert H Lurie Children's Hospital of Chicago; Feinberg School of Medicine, Northwestern University
Recruiting
Efficacy and Safety Study of GSK3772847 in Subjects With Moderately Severe Asthma

Condition: Asthma
Interventions: Drug: GSK3772847; Drug: Placebo; Drug: Fluticasone propionate/salmeterol; Drug: Fluticasone propionate
Sponsor: GlaxoSmithKline
Recruiting
Clinical Performance of the HRP2 HS-RDT for Malaria Diagnosis in Pregnant Women

Conditions: Plasmodium Falciparum; Pregnancy Malaria; Diagnoses Disease
Intervention: Diagnostic Test: HS-RDT
Sponsors: Foundation for Innovative New Diagnostics, Switzerland; Universidad de Antioquia
Recruiting
Adiponectin, IL-6 and hsC-RP in Relation to Carotid Intima-media Thickness in B-thalassemia Patients

Condition: Thalassemia
Interventions: Diagnostic Test: Interleukin-6; Diagnostic Test: HsC-RP; Diagnostic Test: Adiponectin level; Diagnostic Test: Carotid intima media thickness
Sponsor: Assiut University
Not yet recruiting
Gene Study for Infantile Onset Diabetes

Condition: Study Genetic Basis of Infantile Onset Diabetes Mellitus
Intervention: Genetic: Human Leucocytic antigen typing and mutation of adenosine triphosphate sensitive K channel gene in diabetic patients diagnosed under the age of one year.
Sponsor: Assiut University
Not yet recruiting
CES1 Carriers in the PAPI Study

Conditions: Heart Diseases; Coronary Disease; Coronary Artery Disease; Cardiovascular Diseases; Myocardial Ischemia; Artery Occlusion; Aspirin Sensitivity; Clopidogrel, Poor Metabolism of; Platelet Dysfunction; Platelet Thrombus
Interventions: Drug: Clopidogrel; Drug: Aspirin
Sponsor: University of Maryland
Not yet recruiting
Nutrition-sensitive Agricultural Interventions for Ethiopia

Conditions: Dietary Modification; Health Behavior
Interventions: Other: ACGG; Behavioral: BCC
Sponsors: Harvard School of Public Health; International Livestock Research Institute; Addis Continental Institute of Public Health; Food, Agriculture and Natural Resources Policy Analysis Network
Recruiting
The Relationship Between Saliva β-endorphins Levels, Cold Pressor Test and Perception of Pain in Oral Surgery Procedures

Conditions: Hyperalgesia; Pain Insensitivity, Congenital
Interventions: Device: Cold pressor test; Other: β-endorphins evaluation in saliva; Other: β-endorphins evaluation in blood plasma
Sponsor: Lithuanian University of Health Sciences
Not yet recruiting
Linking Epidermal Barrier Function With Anti-Oxidant Defense Mechanisms in Atopic Dermatitis

Condition: Atopic Dermatitis
Intervention:
Sponsor: University of Arizona
Recruiting
A Biomarker to Detect Salt Sensitivity

Conditions: Hypertension Uncomplicated; Pre Hypertension
Intervention: Diagnostic Test: High and low salt diets
Sponsor: University of Minnesota - Clinical and Translational Science Institute
Recruiting
Clinical Evaluation of Hylo-Dual Versus Patanol in Children With Seasonal Allergic Conjunctivitis

Conditions: Conjunctivitis, Allergic; Conjunctivitis, Vernal
Interventions: Drug: Hyaluronic acid 0.05% & Ectoine 2.0%; Drug: Olopatadine hydrochloride ophthalmic solution 0.1%
Sponsors: Michael Marchand, MD; Université de Montréal
Recruiting
Insulin Sensitivity During Hyperbaric Oxygen Compared to Hyperbaric Air

Conditions: Diabetes Mellitus, Type II; Insulin Resistance
Interventions: Procedure: HBO; Procedure: Hyperbaric air
Sponsors: University of Adelaide; Royal Adelaide Hospital Research Committee
Not yet recruiting
The Electronic Asthma Management System

Condition: Asthma
Intervention: Other: Electronic Asthma Management System: eAMS
Sponsors: St. Michael's Hospital, Toronto; Ontario Lung Association
Not yet recruiting
Assessment of Asthma Exacerbation in Children by Modified Pulmonary Index Score

Condition: Bronchial Asthma
Intervention:
Sponsor: Assiut University
Not yet recruiting
Efficacy, Safety, and Pharmacokinetics of APT-1011 in Subjects With Eosinophilic Esophagitis (EoE)

Condition: Eosinophilic Esophagitis
Interventions: Drug: APT-1011; Drug: Placebo
Sponsor: Adare Pharmaceuticals, Inc.
Recruiting
Treatment of Chronic Urticarial Unresponsive to H1-antihistamines With an Anti-IL5Ralpha Monoclonal Antibody

Condition: Chronic Idiopathic Urticaria
Interventions: Biological: benralizumab; Biological: placebo
Sponsor: Jonathan A. Bernstein, MD
Recruiting
Exercise Snacks and Glutamine to Improve Glucose Control in Adolescents With Type 1 Diabetes

Conditions: Diabetes Mellitus, Type 1; Autoimmune Diseases; Diabetes Mellitus; Endocrine System Diseases; Glucose Metabolism Disorders; Immune System Diseases; Metabolic Diseases
Interventions: Drug: Glutamine vs. Placebo; Other: Exercise
Sponsor: Nemours Children's Clinic
Recruiting
The Association Between Pre-operative Pain Psychology and Hypersensitivity With Poor Functional Outcome After Knee Replacement.

Condition: Outcome After Total Knee Arthroplasty
Intervention: Procedure: total knee arthroplasty
Sponsors: University of Salford; Stockport NHS Foundation Trust
Not yet recruiting
Specific Use-Result of Spiriva Respimat® in Asthmatics

Condition: Asthma
Intervention: Drug: Spiriva Respimat
Sponsor: Boehringer Ingelheim
Recruiting
ELISA Validation of Hypersensitive Rapid Diagnostic Test Results for Detection of P. Falciparum

Condition: Plasmodium Falciparum
Intervention: Diagnostic Test: ELISA validation
Sponsor: University of Oxford
Not yet recruiting
Investigation of the Role of Pictorial Asthma Action Plans to Promote Self-management in Rural Youth With Asthma

Condition: Asthma
Interventions: Behavioral: Pictorial Asthma Action Plan; Behavioral: Written Asthma Action Plan
Sponsor: West Virginia University
Recruiting
A Long-term Safety Study of Fixed Dose Combination Therapy Fluticasone Furoate/Umeclidinium Bromide/Vilanterol Trifenatate in Japanese Subjects With Asthma

Condition: Asthma
Interventions: Drug: FF/UMEC/VI 100/62.5/25 mcg; Drug: FF/UMEC/VI 200/62.5/25 mcg; Drug: Salbutamol; Other: ACQ-7
Sponsors: GlaxoSmithKline; York Bioanalytical Solution; BI Medical.Inc; SRL Mediserch.Inc; Parexel International Japan; Q2 Solutions
Recruiting
Efficacy and Safety Study of Benralizumab in Patients With Uncontrolled Asthma on Medium to High Dose Inhaled Corticosteroid Plus LABA (MIRACLE)

Condition: Asthma
Interventions: Biological: Benralizumab; Biological: Placebo
Sponsor: AstraZeneca
Recruiting
Icotinib Combined With SBRT for Patients With Metastatic Non-squamous NSCLC With EGFR Mutation

Condition: Lung Cancer Stage IV
Interventions: Drug: Icotinib; Radiation: SBRT
Sponsor: Sichuan Cancer Hospital and Research Institute
Not yet recruiting
Evaluating the Effects of Cleansers on the Skin

Condition: Atopic Dermatitis
Interventions: Other: CeraVe® Eczema Soothing Body Wash; Other: Cetaphil® RestoraDerm® Eczema Calming Body Wash; Other: Dove® Sensitive Skin Body Wash; Other: Eucerin® Skin Calming Body Wash; Other: Aveeno® Skin Relief Body Wash; Other: MooGoo® Milk Wash; Other: Free & Clear Liquid Cleanser
Sponsor: University of Arizona
Recruiting
A Study of the Safety and Effectiveness of Benralizumab to Treat Patients With Severe Uncontrolled Asthma.

Condition: Asthma
Interventions: Drug: Benralizumab (Medi-563); Drug: Placebo
Sponsor: AstraZeneca
Recruiting
Efficacy Of Antenatal Maternal Supplementation With GOS/Inulin Prebiotics On Atopic Dermatitis Prevalence In High-Risk One-Year-Old Children

Condition: Dermatitis, Atopic
Interventions: Dietary Supplement: PREBIOTICS; Other: PLACEBO
Sponsor: Nantes University Hospital
Recruiting
Fat Emulsion in Preventing Hypersensitivity Reactions in Patients With Cancer Receiving Carboplatin or Oxaliplatin

Condition: Advanced Malignant Neoplasm
Interventions: Dietary Supplement: Fat Emulsion; Other: Placebo
Sponsors: Mayo Clinic; National Cancer Institute (NCI)
Recruiting
The Application of Impulse Oscillometry on the Diagnosis of ACOS,Asthma and COPD.

Conditions: Asthma-COPD Overlap Syndrome; Asthma; COPD; Diagnoses Disease
Intervention: Diagnostic Test: Impulse Oscillometry
Sponsor: Shengjing Hospital
Recruiting
Effects of Almonds on Insulin Sensitivity in Prediabetes

Condition: PreDiabetes
Interventions: Other: 1.5 oz of whole, natural almonds; Other: Low-fat, high refined starches/sugars
Sponsors: Midwest Center for Metabolic and Cardiovascular Research; Almond Board of California
Recruiting
Description of the Ability to Learn How to Handle Inhaler Devices in Asthma

Condition: Asthma
Interventions: Device: placebo Diskus®; Device: placebo Ellipta®; Device: Pulmicort® Turbuhaler®
Sponsor: University Hospital, Bordeaux
Not yet recruiting
Phase II Multicenter Study of Durvalumab and Olaparib in Platinum tReated Advanced Triple Negative Breast Cancer (DORA)

Condition: Triple Negative Breast Cancer
Interventions: Drug: Olaparib Oral Product; Drug: Olaparib Oral Product in combination with Durvalumab
Sponsors: Kimberly Blackwell; AstraZeneca
Not yet recruiting
Validation of the French Version of the Pain Sensitivity Questionnaire

Conditions: Scheduled Surgery; Healthy Volunteers
Intervention: Behavioral: Psychophysical exploration
Sponsors: University Hospital, Clermont-Ferrand; Inserm U1107 « Neuro-Dol », Clermont-Ferrand, France; Centre Jean Perrin; Klinikum der Universität München, Deutschland
Recruiting
A Study in Subjects With Moderate Atopic Dermatitis

Conditions: Atopic Dermatitis; Eczema, Atopic
Interventions: Drug: ALX-101 Gel 1.5% and ALX-101 Gel Vehicle; Drug: ALX-101 Gel 5% and ALX-101 Gel Vehicle
Sponsor: Ralexar Therapeutics, Inc.
Recruiting
Quality of Life in Patients With Chronic Urticaria

Condition: Chronic Urticaria
Intervention: Other: Hospital Anxiety and Depression Scale
Sponsor: Assiut University
Not yet recruiting
Precision Allergy: Separate Allergies to Male and Female Dogs

Condition: Allergy; Dander
Interventions: Diagnostic Test: Male dog; Diagnostic Test: Female dog
Sponsor: Copenhagen Studies on Asthma in Childhood
Recruiting
Microbiome Insulin Sensitivity Study

Conditions: Obesity; Insulin Resistance; Type2 Diabetes
Intervention:
Sponsors: University of Colorado, Denver; National Institutes of Health (NIH); Children's Hospital Colorado
Recruiting
BBOT: Bacterial Burden in Ortho Trauma Procedures

Condition: Orthopaedic Trauma Infections
Intervention: Diagnostic Test: Highly Sensitive Assays
Sponsor: University of Maryland
Recruiting
The Effect of Topical Brimonidine Tartrate on Hand-foot Syndrome (HFS) in Cancer Patients

Condition: Hand-foot Syndrome
Intervention: Drug: Brimonidine Tartrate
Sponsor: Heinrich-Heine University, Duesseldorf
Recruiting
Autonomic State, Cardiovascular Control and Outcomes in Coronary Surgery

Conditions: Atrial Fibrillation; Acute Kidney Injury
Intervention:
Sponsor: IRCCS Policlinico S. Donato
Recruiting
Validation of Mesopic and Photopic Contrast Vision Tests With Respect to Nighttime Driving Ability

Conditions: Cataract; Traffic Accident; Vision Disorders; Driving Impaired
Intervention: Diagnostic Test: Slit lamp (LOCS III Score)
Sponsors: Aalen University; DGUV (Deutsche Gesetzliche Unfallversicherung/German Social Accident Insurance Institutions); Study Course Ophthalmic Optics and Optometry, University of Applied Sciences Aalen; Study Course Mechatronics, University of Applied Sciences Aalen; Steinbeis Transferzentrum AWFE, University of Applied Sciences Aalen; Würzburg Institute for Traffic Sciences GmbH
Recruiting
Detection of Viral Particels in Urticaria Patients

Condition: Urticaria Chronic
Intervention:
Sponsor: HaEmek Medical Center, Israel
Recruiting
Study to Compare QVM149 and Free Triple Combination of Salmeterol/Fluticasone + Tiotropium

Condition: Asthma
Interventions: Drug: QVM149; Drug: Salmeterol/fluticasone plus tiotropium
Sponsor: Novartis Pharmaceuticals
Recruiting
High Flow Nasal Cannula in Children With Status Asthmaticus

Condition: Status Asthmaticus
Interventions: Device: HFNC; Device: Standard Oxygen Treatment
Sponsor: Hospices Civils de Lyon
Not yet recruiting
Anti-inflammatory Effect of Nocturnal NIPPV on Acute Asthma

Condition: Asthma Acute
Interventions: Device: NIPPV; Device: CPAP
Sponsor: National Institute of Respiratory Diseases, Mexico
Not yet recruiting
Efficacy and Safety of Ojeok-san on Korean Patients With Cold Hypersensitivity in the Hands and Feet

Condition: Cold Hypersensitivity
Interventions: Drug: Ojeok-San; Drug: Placebo
Sponsors: Chan-Yong Jeon; Kyunghee University Oriental Medical Center; Kyung Hee University Hospital at Gangdong; Semyung University second affiliated oriental medical hospital at Chungju
Recruiting
Evaluation of the Efficacy of an Autologous Microbiome Transplant in Adult Atopic Dermatitis Patients

Condition: Atopic Dermatitis Eczema
Intervention: Biological: Autologous Microbial Transplant
Sponsor: University of California, San Diego
Recruiting
Targeted Microbiome Transplant in Atopic Dermatitis

Condition: Atopic Dermatitis (AD)
Interventions: Biological: TMT Lotion; Drug: Placebo Lotion
Sponsors: National Institute of Allergy and Infectious Diseases (NIAID); Atopic Dermatitis Research Network
Recruiting
Clinical Safety & Efficacy of a New Infant Formula With Specific Medical Purpose Containing Human Milk Oligosaccharides

Condition: Cow's Milk Protein Allergy
Interventions: Other: Test infant formula with HMOs; Other: Control infant formula without HMOs
Sponsor: Nestlé
Recruiting
Efficacy and Safety of GDC-0853 in Participants With Refractory Chronic Spontaneous Urticaria (CSU)

Condition: Urticaria
Interventions: Drug: GDC-0853; Drug: Placebo
Sponsor: Genentech, Inc.
Recruiting
Evaluating Skin Barrier Dysfunction in Infants at High Risk of Atopy

Conditions: Atopic Dermatitis; Eczema; Food Allergy
Interventions: Other: Evaluating atopy in infants; Other: Evaluating TEWL and STS in adults
Sponsor: National Jewish Health
Recruiting
Coronary CT Angiography for Improved Assessment of Suspected Acute Coronary Syndrome

Conditions: Acute Coronary Syndrome; Chest Pain
Intervention: Diagnostic Test: Coronary CT Angiography
Sponsor: Admir Dedic
Recruiting
A Longitudinal Investigation of Skin Barrier Development From Birth and the Validation of Early Predictors of Atopic Eczema Risk: the Skin Testing for Atopic Eczema Risk (STAR) Study

Condition: Atopic Eczema
Intervention: Diagnostic Test: Skin Testing for Atopic eczema
Sponsors: Sheffield Teaching Hospitals NHS Foundation Trust; University of Sheffield
Recruiting
Adipose Tissue Expandability and Type 2 Diabetes

Condition: Type2 Diabetes Mellitus
Intervention:
Sponsor: Charles University, Czech Republic
Recruiting
Periostin-guided Withdrawal of Inhaled Corticosteroids in Patients With Non-eosinophilic Asthma

Condition: Asthma
Intervention: Other: Tapering of ICS treatment
Sponsor: Hvidovre University Hospital
Not yet recruiting
Asthma Origins and Remission Study

Condition: Asthma
Intervention:
Sponsors: University Medical Center Groningen; GlaxoSmithKline
Recruiting
Maximizing Analgesia to Reduce Pain in Knee Osteoarthritis

Condition: Knee Osteoarthritis
Intervention: Drug: Blinded study medication
Sponsor: Johns Hopkins University
Recruiting
A Bronchoprovocation Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of CSJ117 in Adult Subjects With Mild Atopic Asthma

Condition: Asthma
Interventions: Drug: CSJ117; Drug: Placebo Comparator
Sponsor: Novartis Pharmaceuticals
Not yet recruiting
The Role of Food Sensitivity in Psoriasis

Condition: Psoriasis
Intervention: Other: 12-week elimination diet
Sponsor: University of Michigan
Recruiting
Reducing Diagnostic Error to Improve Patient Safety in COPD and Asthma (REDEFINE Study)

Condition: COPD Asthma
Interventions: Device: Spirometry; Drug: Albuterol
Sponsors: University of Illinois at Chicago; Agency for Healthcare Research and Quality (AHRQ)
Recruiting
Prevalence of Severe Asthma in Spanish Hospitals

Condition: Asthma
Interventions: Other: Questionnaire; Other: Software of Big Data
Sponsors: GlaxoSmithKline; Quintiles IMS
Recruiting
Allogeneic Human Cells (hMSC) Via Intravenous Delivery in Patients With Mild Asthma

Condition: Asthma
Intervention: Biological: hMSCs
Sponsor: Marilyn Glassberg
Recruiting
Stress and Treatment Response in Puerto Rican Children With Asthma

Condition: Asthma in Children
Intervention: Drug: Inhaled corticosteroid (mometasone)
Sponsors: University of Pittsburgh; National Heart, Lung, and Blood Institute (NHLBI)
Not yet recruiting
Role of Circulating Innate Lymphoid Cells in Allergic Disorders

Conditions: Allergy; Asthma; Urticaria
Intervention:
Sponsor: University of Nebraska
Recruiting
The Effect of Gluten-free Diet in Type 1 Diabetics With Dyspepsia Symptoms

Conditions: Diabetes Mellitus, Type 1; Gastroparesis; Dyspepsia; Gluten Sensitivity
Intervention: Other: Gluten-free diet
Sponsor: McMaster University
Recruiting
Dexamethasone Versus Prednisone for Asthma Treatment in the Pediatric Inpatient Population; a Feasibility Study

Condition: Asthma
Interventions: Drug: Dexamethasone; Drug: Prednisone
Sponsor: Children's Hospital of Eastern Ontario
Not yet recruiting
A Study Evaluating Vitamin D in Allergic Bronchopulmonary Aspergillosis Complicating Asthma

Condition: Allergic Bronchopulmonary Aspergilloses
Interventions: Drug: Glucocorticoids; Drug: Vitamin D
Sponsor: Postgraduate Institute of Medical Education and Research
Not yet recruiting
Sensitivity of Extended Cultures in Diagnosing Urinary Tract Infections

Conditions: Overactive Bladder; Overactive Detrusor; Urgency-Frequency Syndrome; UTI
Intervention: Procedure: Extended Urine Culture
Sponsor: The Cleveland Clinic
Recruiting
Study of HIV-Infected and Uninfected Pregnant Woman/Child Dyads in Gabarone, Botawana

Conditions: HIV; Insulin Sensitivity; Diabetes Mellitus
Interventions: Drug: Zidovudine; Drug: Nevirapine
Sponsors: Icahn School of Medicine at Mount Sinai; National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting
Non-interventional Study to Assess the Tolerability and the Safety Profile of SCIT Therapy With Acarovac® Hausstaubmilbe

Condition: Perennial Allergic Rhinitis
Intervention: Drug: Acarovac
Sponsors: University Hospital of Cologne; Bencard Allergie GmbH
Recruiting
Breathing Exercises in Asthma Targeting Dysfunctional Breathing

Condition: Dysfunctional Breathing in Asthma
Interventions: Other: Breathing Exercises; Other: Usual care
Sponsors: Naestved Hospital; Zealand University Hospital; Hvidovre University Hospital; Aalborg Universitetshospital; Bispebjerg Hospital; TrygFonden, Denmark; Slagelse Hospital; Region Zealand; Association of Danish Physiotherapists
Recruiting
Assess Bronchodilator Effect QVM149 Dosed Either in the Morning or Evening Compared to Placebo in Patients With Asthma

Condition: Asthma
Interventions: Drug: Treatment A: Matching placebo (morning dose) and QVM149 150/50/80 μg (evening dose); Drug: Treatment B: QVM149 150/50/80 μg (morning dose) and matching placebo (evening dose); Drug: Treatment C: Placebo (morning dose) and placebo (evening dose)
Sponsor: Novartis Pharmaceuticals
Recruiting
Role of Immunoglobulin E (IgE) Bearing Cells in Chronic Idiopathic Urticaria (CIU)

Condition: Urticaria Chronic
Intervention: Drug: Omalizumab
Sponsors: Johns Hopkins University; National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting
A Clinical Study to Investigate the Effect of a Partially Hydrolysed Infant Formula With Added Synbiotics on Gut Microbiota Composition and Clinical Effectiveness in Infants at High Risk of Developing Allergy

Condition: Immunity
Interventions: Other: Infant formula with added synbiotics; Other: Standard infant formula
Sponsor: Nutricia Research
Recruiting
Study of REGN3500 and Dupilumab in Patients With Asthma

Condition: Asthma, Allergic
Interventions: Drug: REGN3500; Drug: Dupilumab; Drug: Placebo; Drug: Fluticasone propionate
Sponsors: Regeneron Pharmaceuticals; Sanofi
Recruiting
A Clinical Study to Investigate the Effect of a Partially Hydrolysed Infant Formula With Added Synbiotics on the Development of Allergic Manifestations in Infants at High Risk of Developing Allergy

Condition: Immunity
Interventions: Other: Infant Formula with added synbiotics; Other: Standard Infant formula
Sponsor: Nutricia Research
Not yet recruiting
Sensory-Mechanical Responses to Eucapneic Voluntary Hyperventilation and Hypertonic Saline

Conditions: Asthma; Cough; Cough Variant Asthma
Interventions: Drug: Methacholine (MCh) Challenge Testing; Diagnostic Test: Eucapneic Voluntary Hyperventilation (EVH) and Hypertonic Saline (HS) Challenge Tests
Sponsor: Queen's University
Not yet recruiting
Metabolomics for Biomarker Discovery in Children With EoE

Condition: Eosinophilic Esophagitis
Intervention: Diagnostic Test: Plasma and urine metabolomics
Sponsors: The University of Texas Health Science Center, Houston; Baylor College of Medicine
Recruiting
Research for Specific Proteins of Interest for the Serological Diagnosis of Bird Fancier's Lung

Condition: Avian Hypersensitivity Pneumonitis
Interventions: Other: additional blood sample; Other: respiratory functional exploration
Sponsor: Centre Hospitalier Universitaire de Besancon
Recruiting
Combining Donepezil With Perceptual Learning in Normal and Amblyopic Human The Effect of Donepezil on Perceptual Learning in Adult Amblyopia

Condition: Amblyopia
Interventions: Drug: Donepezil; Behavioral: Single-letter training; Behavioral: Uncrowd training
Sponsor: Dennis Levi
Recruiting
Procalcitonin for Stewardship in Respiratory Infections A Stewardship Project

Condition: LRTI
Intervention: Device: PCT Arm
Sponsor: Johns Hopkins University
Recruiting
Race Adiposity Interactions Regulate Mechanisms Determining Insulin Sensitivity

Conditions: Insulin Sensitivity; Fat; Liver
Intervention:
Sponsor: University of Alabama at Birmingham
Recruiting
Medical and Physiological Benefits of Reduced Sitting

Conditions: Metabolic Syndrome; Physical Activity; Insulin Resistance; Cardiovascular Diseases
Intervention: Behavioral: Reduced sitting
Sponsors: Turku University Hospital; UKK Institute
Recruiting
Is the Current Threshold for Diagnosis of "Abnormality", Including Non ST Elevation Myocardial Infarction, Using Raised Highly Sensitive Troponin Appropriate for a Hospital Population? The CHARIOT Study

Condition: Myocardial Infarction
Intervention:
Sponsor: University Hospital Southampton NHS Foundation Trust
Not yet recruiting
Leukotriene Antagonism in Recruitment of CD49d Expressing Neutrophils in Atopic Subjects

Condition: Nasal Allergy
Interventions: Procedure: Nasal lavage; Procedure: Nasal allergen challenge; Procedure: Epicutaneous skin testing; Procedure: Peripheral blood; Drug: Montelukast 10Mg Tablet; Drug: Placebo Oral Tablet
Sponsors: Mitchell Grayson; National Heart, Lung, and Blood Institute (NHLBI)
Recruiting
Revlimid® Capsules Drug Use-results Surveillance (Relapsed or Refractory ATLL)

Condition: Lymphoma
Intervention: Drug: Revlimid
Sponsor: Celgene
Recruiting
Inflammation and Threat Sensitivity in PTSD

Condition: Posttraumatic Stress Disorder
Interventions: Biological: Typhoid Vi Polysaccharide Vaccine; Biological: Placebo
Sponsors: University of California, San Francisco; National Institute of Mental Health (NIMH)
Not yet recruiting
Assessment of Bronchial Thickness Using MRI in Asthma

Condition: Asthma
Interventions: Diagnostic Test: Magnetic Resonance Imaging (MRI) with Ultrashort Echo Time (UTE); Diagnostic Test: Computed tomography (CT)
Sponsor: University Hospital, Bordeaux
Recruiting
Sleep & Quality of Life Evaluation of Patients With Atopic Dermatitis Based on E-diary on a Smartphone Application and Actigraphy

Condition: Atopic Dermatitis Eczema
Intervention: Other: electronic-Patient Report Outcome and wear of a wristband actigraph
Sponsor: Ad scientiam
Recruiting
Gynaecological Disorders in Not-celiac Wheat Sensitivity

Condition: Non-celiac Wheat Sensitivity
Intervention: Other: Gluten free diet
Sponsor: University of Palermo
Recruiting
Treatment of Atopic Dermatitis by a Full‐Body Blue Light Device

Condition: Dermatitis, Atopic
Intervention: Device: Full Body Blue Light Device
Sponsors: Philips Light and Health; University Hospital Goettingen; Philipps University Marburg Medical Center; University Hospital, Geneva
Recruiting
Impact of Narrowband UVB Phototherapy on Systemic Inflammation in Patients With Atopic Dermatitis

Condition: Atopic Dermatitis
Intervention: Other: Narrow band UVB treatment (NB-UVB)
Sponsor: Rockefeller University
Recruiting
Response to Different Wheat Genotypes in Not-celiac Wheat Sensitivity

Condition: Non-celiac Wheat Sensitivity
Interventions: Dietary Supplement: Wheat flour; Dietary Supplement: Placebo
Sponsor: University of Palermo
Recruiting
Fibromyalgia-like Joint/Muscle Pain and Synovitis in Non-celiac Wheat Sensitivity Patients

Condition: Non-celiac Wheat Sensitivity
Intervention: Other: Gluten free diet
Sponsor: University of Palermo
Not yet recruiting
Red Raspberry Polyphenols on Gut Microbiome

Conditions: Healthy Subjects; Pre-diabetes
Interventions: Dietary Supplement: Raspberry and fructooligosaccharide; Dietary Supplement: Raspberry
Sponsor: Institute for Food Safety and Health, United States
Recruiting
A New Wizard for Insulin Sensitivity Estimation From SAP: a Randomized Controlled Trial in Adolescents With T1D

Condition: Diabetes Mellitus
Intervention: Other: individualized insulin sensitivity index (ISind)
Sponsor: Yale University
Not yet recruiting
Sponge and Eosinophil Peroxidase (EPO) Staining

Condition: Eosinophilic Esophagitis
Intervention: Device: swallowed sponge device
Sponsor: Mayo Clinic
Recruiting
Early Peanut Introduction: Translation to Clinical Practice

Condition: Peanut Allergy
Intervention: Other: Peanut in diet
Sponsors: Johns Hopkins University; National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting
Validation of an Allergic Rhinitis Control Test in Children

Condition: Allergic Rhinitis
Intervention: Other: Self Questionnaire
Sponsor: University Hospital, Montpellier
Recruiting
Effect of Yakult Ingestion on Diet-induced Insulin Resistance in Humans

Conditions: Insulin Sensitivity; Insulin Resistance; Type 2 Diabetes Mellitus
Intervention: Dietary Supplement: Yakult light
Sponsors: Loughborough University; Yakult Honsha Co., LTD
Recruiting
Nivolumab, Ipilimumab and COX2-inhibition in Early Stage Colon Cancer: an Unbiased Approach for Signals of Sensitivity

Condition: Colon Carcinoma
Interventions: Drug: Nivolumab; Drug: Ipilimumab; Drug: Celecoxib 200mg
Sponsors: The Netherlands Cancer Institute; Bristol-Myers Squibb
Recruiting
Lactose Intolerance and Cow's Milk Protein Allergy in Non-celiac Wheat Sensitivity Patients

Condition: Non-celiac Wheat Sensitivity
Interventions: Other: Lactose breath test; Other: DBPC cow's milk protein challenge
Sponsor: University of Palermo
Recruiting
Racial Differences in Vagal Control of Glucose Homeostasis, Chronic Study

Conditions: Insulin Sensitivity; Oxidative Stress
Interventions: Drug: Galantamine; Drug: Placebo
Sponsor: Vanderbilt University Medical Center
Recruiting
Assess Bronchodilator Effect and Safety of Two Doses of QVM149 Compared to a Fixed Dose Combination of Salmeterol/Fluticasone in Patients With Asthma.

Condition: Asthma
Interventions: Drug: QVM149 150/50/80 μg o.d.; Drug: QVM149 150/50/160 μg o.d.; Drug: salmeterol/fluticasone FDC 50/500 μg b.i.d.
Sponsor: Novartis Pharmaceuticals
Recruiting
Determination of the Sensitivity and Specificity of a Smartphone Application to Detect Retinoblastoma

Conditions: Retinoblastoma; Cataracts Infantile; Glaucoma, Congenital; Leucocoria
Interventions: Other: CRADLE; Other: Red reflex testing
Sponsor: St. Jude Children's Research Hospital
Recruiting
EXhaled Hydrogen Peroxide As a Marker of Lung diseasE (EXHALE) Pilot Study.

Conditions: Asthma; Chronic Obstructive Pulmonary Disease
Intervention: Device: The Inflammacheck Device
Sponsors: Portsmouth Hospitals NHS Trust; Asthma UK
Recruiting
Diet Composition and Physical Inactivity on Insulin Sensitivity and β-cell Function

Conditions: Physical Inactivity; Dietary Protein
Intervention: Behavioral: activity level
Sponsors: University of Missouri-Columbia; American Egg Board
Recruiting
TREATgermany: German National Clinical Registry for Patients With Moderate-to-severe Atopic Dermatitis

Condition: Moderate-to-severe Atopic Dermatitis
Intervention: Other: No study intervention
Sponsor: Technische Universität Dresden
Recruiting
Study of Safety of QAW039 in Patients With Asthma Inadequately Controlled on Standard-of-care Asthma Treatment

Condition: Asthma
Interventions: Drug: QAW039 Dose 1; Drug: QAW039 Dose 2; Drug: Placebo
Sponsor: Novartis Pharmaceuticals
Recruiting
C1-inhibitor in Allergic ASThma Patients

Condition: Asthma
Interventions: Drug: C1-inhibitor; Other: Saline; Drug: Antibiotics
Sponsors: T. van der Poll; ZonMw: The Netherlands Organisation for Health Research and Development; Sanquin
Recruiting
Efficacy of Combining Topical Antibiotic/Steroid/Moisturizer Therapy Compared to Active Comparator in Atopic Dermatitis.

Condition: Severe Atopic Dermatitis
Interventions: Other: Polyethylene glycol hexadecyl ether & Betamethasone valerate cream 0.1%; Other: Fusidic acid, polyethylene glycol hexadecyl ether & Betamethasone valerate cream 0.1%
Sponsor: Red Cross War Memorial Childrens Hospital
Not yet recruiting
PALISADE Follow-on Study (ARC004)

Condition: Peanut Allergy
Intervention: Biological: AR101
Sponsor: Aimmune Therapeutics, Inc.
Recruiting
Asthma and Atopic Dermatitis Validation of PROMIS Pediatric Instruments

Conditions: Atopic Dermatitis; Ichthyosis; Psoriasis
Interventions: Other: Itch Questionnaire and Interview; Other: Stigma Questionnaire and Interview; Other: Cognitive Interview and PROMIS Itch Questionnaire
Sponsor: Northwestern University
Recruiting
HAL-MPE1 Safety and Tolerability Study

Condition: Peanut Allergy
Interventions: Biological: HAL-MPE1; Drug: HAL-MPE1 placebo
Sponsor: HAL Allergy
Recruiting
Children-Adult Asthma Cohort Study in China

Condition: Asthma in Children
Intervention:
Sponsors: Beijing Children's Hospital; Shengjing Hospital; Capital Institute of Pediatrics, China; Xinhua Hospital, Shanghai Jiao Tong University School of Medicine; China-Japan Friendship Hospital; Ruijin Hospital; Xiangya Hospital of Central South University; Beijing Chao Yang Hospital
Not yet recruiting
Precise Local Injection of Anti-cancer Drugs Using Presage's CIVO™ Device in Soft Tissue Sarcoma

Condition: Soft Tissue Sarcoma Adult
Interventions: Drug: Multiple drug microinjection; Device: CIVO device
Sponsors: Presage Biosciences; Fred Hutchinson Cancer Research Center; University of Washington; Northwell Health
Recruiting
Magnesium Supplementation in Type II Diabetes

Condition: Effect of Magnesium in Diabetes
Interventions: Dietary Supplement: Magnesium citrate; Dietary Supplement: Placebo
Sponsor: Protina Pharmazeutische GmbH
Recruiting
The RECONSTRUCT Study - Reconstructing Disease Mechanisms in Asthma

Condition: Asthma
Intervention: Drug: Budesonide
Sponsor: Bispebjerg Hospital
Recruiting
Traditional Chinese Medicine on Gut Microbiota and Allergic Diseases

Condition: Allergic Rhinitis
Interventions: Drug: Bu-Zhong-Yi-Qi-Tang; Drug: placebo
Sponsor: Chang Gung Memorial Hospital
Recruiting
Biofeedback for Asthma Comorbid With Anxiety or Depression

Conditions: ASTHMA; ANXIETY
Intervention: Behavioral: heart rate variability biofeedback
Sponsor: Rutgers, The State University of New Jersey
Not yet recruiting
Oral Ifetroban to Treat Aspirin Exacerbated Respiratory Disease (AERD)

Condition: Asthma, Aspirin-Induced
Interventions: Drug: Ifetroban Oral Capsule; Drug: Placebo Oral Capsule
Sponsor: Cumberland Pharmaceuticals
Recruiting
Folate Receptor Alpha Peptide Vaccine With GM-CSF Versus GM-CSF Alone in Patients With Platinum Sensitive Ovarian Cancer

Conditions: Platinum Sensitive Ovarian Cancer; Ovarian Cancer
Interventions: Biological: FRα peptide plus Adjuvant (GM-CSF); Drug: Adjuvant (GM-CSF) Alone
Sponsor: Tapimmune Inc.
Recruiting
Olaparib Tablets as a Treatment for Ovarian Cancer Subjects With Different HRD Tumor Status

Condition: Relapsed Ovarian Cancer, BRCA Mutation, Platinum Sensitivity
Intervention: Drug: OLAPARIB
Sponsor: AstraZeneca
Recruiting
Insulin Sensitivity, Glucose - and Fat Metabolism in Patients With Psoriasis

Conditions: Insulin Sensitivity; Metabolism Disorder
Intervention: Other: Stabile Isotope tracers
Sponsor: University Hospital, Gentofte, Copenhagen
Recruiting
Biomarker for Hereditary Angioedema Disease Type 1

Conditions: Hereditary AngioEdema; Angioedema, Hereditary; Angio-Oedema of Lips; Angio-Oedema of Tongue
Intervention:
Sponsors: University of Rostock; Centogene AG Rostock
Recruiting
High-Sensitivity Cardiac Troponin T to OPtimize Chest Pain Risk Stratification

Conditions: Acute Coronary Syndrome; Chest Pain
Interventions: Procedure: Blood Sample; Behavioral: HEART Score
Sponsors: University of Florida; Roche Diagnostics
Recruiting
Within-day and Between-day Repeatability of the Breath Pattern in Healthy Children and in Children With Asthma

Conditions: Asthma; Healthy
Intervention: Other: Assessment of E-nose measurements
Sponsors: Istituto di Biomedicina e Immunologia Molecolare Alberto Monroy; Campus Bio-Medico University
Recruiting
Inflammatory Back Pain and Gluten Free Diet

Condition: Inflammatory Back Pain
Intervention: Other: Gluten free diet
Sponsor: University of Palermo
Not yet recruiting
Exercise and Insulin Signaling in Human Skeletal Muscle

Conditions: Insulin Sensitivity; Obesity; Sedentary Lifestyle
Intervention: Behavioral: Exercise
Sponsor: Oregon State University
Recruiting
A Study to Improve the FAST Ultrasound Exam

Condition: Hemoperitoneum
Intervention: Procedure: Fast exam
Sponsor: The Guthrie Clinic
Recruiting
Beginning Assessment of Cutaneous Treatment Efficacy of Roseomonas in Atopic Dermatitis

Condition: Atopic Dermatitis
Intervention: Biological: Roseomonas mucosa
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting
Genotype-tailored Treatment of Symptomatic Acid-Reflux in Children With Uncontrolled Asthma

Conditions: Asthma; Gastroesophageal Reflux
Interventions: Drug: commercially available lansoprazole; Drug: matched placebo
Sponsors: Jason Lang, M.D., M.P.H.; Thrasher Research Fund; Nemours Children's Clinic
Recruiting
Response of the Airway in Sinusitis and Asthma

Conditions: Sinusitis; Asthma
Interventions: Drug: Mometasone Nasal; Drug: placebo mometasone
Sponsor: Medical Universtity of Lodz
Recruiting
Evaluating the Safety and Efficacy of Fecal Microbiota Transplant in Peanut Allergic Patients

Condition: Peanut Allergy
Intervention: Biological: Fecal Microbiota Capsule
Sponsor: Rima Rachid
Recruiting
Improving Glucose and Lipid Metabolism Through Caloric Restriction Using Diet or Surgery (CRUDOS)

Conditions: Type2 Diabetes; Weight Loss; Insulin Sensitivity; Metabolism and Nutrition Disorder; Metabolism Disorder, Glucose; Bariatric Surgery Candidate
Interventions: Procedure: Gastric by-pass surgery; Dietary Supplement: Low-caloric diet
Sponsors: Uppsala University; AstraZeneca
Recruiting
Study of Efficacy and Safety of Pirfenidone in Patients With Fibrotic Hypersensitivity Pneumonitis

Condition: Interstitial Lung Disease
Interventions: Drug: Pirfenidone; Other: Placebo controlled
Sponsors: National Jewish Health; Genentech, Inc.
Recruiting
Contribution of Hyperinsulinemia vs. Hyperglycemia to Insulin Resistance in Type 1 Diabetes and Maturity Onset Diabetes of the Young, Type 2 (MODY2)

Conditions: Type 1 Diabetes Mellitus; Maturity-Onset Diabetes of the Young, Type 2; MODY2; Insulin Resistance
Interventions: Drug: Hyperinsulinemic, euglycemic clamp; Drug: 20% dextrose
Sponsor: Vanderbilt University
Recruiting
Dairy Products, Diabetes and Genetics

Conditions: Insulin Sensitivity; Type2 Diabetes
Interventions: Behavioral: Increased dairy product; Behavioral: Dietary counselling
Sponsors: CHU de Quebec-Universite Laval; Canadian Institutes of Health Research (CIHR)
Recruiting
TB Host Directed Therapy

Condition: Tuberculosis
Interventions: Drug: Everolimus 0.5 MG; Drug: Auranofin 6 MG; Drug: Vitamin D3; Drug: CC-11050; Drug: 2HRbZE/4HRb
Sponsor: The Aurum Institute NPC
Recruiting
A Trial of a Botanical Drug Product Containing East Indian Sandalwood Oil (EISO) For Treatment of Atopic Dermatitis

Condition: Atopic Dermatitis
Interventions: Drug: SAN007 Cream; Drug: Placebo
Sponsors: Santalis Pharmaceuticals, Inc.; ClinDatrix, Inc.; Fremantle Dermatology
Not yet recruiting
Assessing the Effects of Intranasal Fluticasone Plus Azelastine on Airway Inflammation in Patients With Asthma and Allergic Rhinitis

Conditions: Asthma, Allergic; Rhinitis,Allergic; Allergy
Interventions: Drug: Azelastine-Fluticasone Nasal; Drug: Placebos
Sponsor: University of Dundee
Recruiting
Patient Empowered Strategy to Reduce Asthma Morbidity in Highly Impacted Populations; PeRson EmPowered Asthma RElief

Condition: Asthma
Intervention: Drug: PARTICS using QVAR
Sponsors: Brigham and Women's Hospital; Patient-Centered Outcomes Research Institute; American Academy of Family Physicians
Recruiting
Mucosal Impedance Balloon in Diagnosis and Treatment of Eosinophilic Esophagitis (EoE)

Conditions: Eosinophilic Esophagitis; Healthy
Intervention: Device: Mucosal Impedance Balloon catheter
Sponsors: Mayo Clinic; Sandhill Scientific
Recruiting
Home Telemonitoring of Resting Spontaneous Breathing in Severe Asthma: a Pilot Study

Condition: Asthma
Intervention: Device: anharmonic morphological analysis of the respiratory signals (AMARS)
Sponsor: University Hospital, Bordeaux
Recruiting
A Study to Monitor the Use of an Amino Acid-Based Infant Formula

Conditions: Cow's Milk Protein Allergy; Eosinophilic Gastrointestinal Disorders; Malabsorption/Maldigestion; Short Bowel Syndrome; Multiple Food Allergies
Intervention: Other: Free amino acid infant formula
Sponsor: Nestlé
Recruiting
Clinical Study, Non Inferiority Between Noex® 50µg Versus Busonid® 50µg in Treatment of Allergic Rhinitis

Condition: Rhinitis, Allergic, Perennial
Interventions: Drug: Budesonid 50mcg (Noex); Drug: Budesonid 50mcg (Busonid)
Sponsor: Eurofarma Laboratorios S.A.
Not yet recruiting
Diet, Insulin Sensitivity, and Postprandial Metabolism

Conditions: Overweight; Obesity; Insulin Resistance
Interventions: Other: Plant-based diet; Other: Control Diet
Sponsors: Physicians Committee for Responsible Medicine; Yale University
Recruiting
Errors in the Use of Turbuhaler and Spiromax Devices Patients With Asthma

Condition: Asthma
Interventions: Device: TURBUHALER®; Device: SPIROMAX®
Sponsor: Fundación Pública Andaluza Progreso y Salud
Recruiting
Study of Fluticasone Propionate Multidose Dry Powder Inhaler Compared With Fluticasone Propionate/Salmeterol Multidose Dry Powder Inhaler

Condition: Asthma
Interventions: Drug: Fp MDPI; Drug: FS MDPI; Drug: Placebo
Sponsor: Teva Branded Pharmaceutical Products, R&D Inc.
Recruiting
Olaparib, Durvalumab, and Tremelimumab in Treating Patients With Recurrent or Refractory Ovarian, Fallopian Tube or Primary Peritoneal Cancer With BRCA1 or BRCA2 Mutation

Conditions: BRCA1 Gene Mutation; BRCA2 Gene Mutation; Ovarian Serous Adenocarcinoma; Recurrent Fallopian Tube Carcinoma; Recurrent Ovarian Carcinoma; Recurrent Primary Peritoneal Carcinoma
Interventions: Biological: Durvalumab; Other: Laboratory Biomarker Analysis; Drug: Olaparib; Biological: Tremelimumab
Sponsors: Roswell Park Cancer Institute; National Cancer Institute (NCI)
Recruiting
Posterior Ligament Complex Assessment Without Magnetic Resonance Image in Thoracolumbar Fractures

Conditions: Spinal Deformity; Spinal Fractures; Spinal Injuries; Kyphosis
Intervention: Other: Retrospective radiological evaluation
Sponsor: AO Clinical Investigation and Documentation
Recruiting
Placebo-Controlled Study to Investigate ANB020 Activity in Adult Patients With Peanut Allergy

Condition: Peanut Allergy
Interventions: Drug: ANB020; Drug: Placebo
Sponsor: AnaptysBio, Inc.
Recruiting
Feeding Behavior and Taste Sensitivity Before and After Liver or Renal Transplantation

Conditions: Cirrhosis; Food Preferences; Taste Disorders; Protein-Energy Malnutrition; Chronic Renal Failure
Intervention:
Sponsor: University of Burgundy
Recruiting
Clinical Study, Non Inferiority Between Noex® 32µg Versus Budecort Aqua® 32µg in Treatment of Alergic Rhinitis

Condition: Rhinitis, Allergic, Perennial
Intervention: Drug: Budesonide
Sponsor: Eurofarma Laboratorios S.A.
Not yet recruiting
Comparison of Albuterol for Status Asthmaticus

Condition: Status Asthmaticus
Intervention: Drug: preservative free albuterol
Sponsors: University of Louisville; Norton Healthcare
Not yet recruiting
Treatment of Idiopathic Angioedema With Xolair as Add-on Therapy

Condition: Idiopathic Angioedema
Interventions: Drug: Omalizumab; Drug: Placebos
Sponsors: University of Wisconsin, Madison; Novartis Pharmaceuticals
Recruiting
VCRC Tissue Repository

Conditions: Aortitis; Cutaneous Vasculitis; Eosinophilic Granulomatosis With Polyangiitis; Giant Cell Arteritis; Granulomatosis With Polyangiitis (Wegener's); Henoch-Schonlein Purpura; IgA Vasculitis; Microscopic Polyangiitis; Polyarteritis Nodosa; Takayasu Arteritis; Churg-Strauss Syndrome
Intervention:
Sponsors: University of Pennsylvania; National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS); National Center for Advancing Translational Science (NCATS); Office of Rare Diseases (ORD)
Recruiting
Efficacy and Safety of the Mometasone Nasal Gel in the Treatment of Persistent Allergic Rhinitis

Condition: Allergic Rhinitis
Interventions: Drug: EMS Mometasone gel; Drug: Mometasone spray nasal
Sponsor: EMS
Not yet recruiting
Efficacy and Safety of the Mometasone Nasal Gel in the Treatment of Persistent Allergic Rhinitis

Condition: Allergic Rhinitis
Interventions: Drug: EMS Mometasone gel; Drug: Mometasone spray nasal
Sponsor: EMS
Not yet recruiting
Expressions of TRPV1 in Airway of Asthmatics

Conditions: Moderate Persistent Asthma; Severe Persistent Asthma; Nodule Solitary Pulmonary; Pulmonary Atelectasis
Intervention: Procedure: Bronchial biopsy
Sponsor: Lu Yuan Lee
Not yet recruiting
Evaluation of Dupilumab in Children With Uncontrolled Asthma

Condition: Asthma
Interventions: Drug: Dupilumab; Other: Placebo; Drug: Asthma Controller Therapies (incl. prednisone/prednisolone); Drug: Asthma Reliever Therapies
Sponsors: Sanofi; Regeneron Pharmaceuticals
Recruiting
Association Between Asthma and Food Allergy

Conditions: Food Allergy Suspected; Food Allergy Proved
Intervention: Other: Pulmonary function test
Sponsor: University Hospital, Montpellier
Recruiting
Brown Fat Activation Study

Conditions: Obese; Metabolic Syndrome
Interventions: Drug: Mirabegron; Drug: Pioglitazone; Drug: Mirabegron and Pioglitazone
Sponsors: Philip Kern; National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting
Clinical Trial Comparing JDP-205 to Diphenhydramine Injection for the Treatment of Acute Urticaria

Condition: Acute Urticaria
Interventions: Drug: Test Drug (JDP-205); Drug: Active Control (Diphenhydramine)
Sponsor: JDP Therapeutics, Inc.
Recruiting
Asthma L-Citrulline Pilot Study

Condition: Asthma
Intervention: Dietary Supplement: L-Citrulline
Sponsor: University of Colorado, Denver
Recruiting
E-B-FAHF-2, Multi OIT and Xolair (Omalizumab) for Food Allergy

Condition: Food Allergy
Interventions: Drug: Chinese Herbal Medication; Drug: Placebo; Drug: Omalizumab; Drug: Multi OIT
Sponsor: Xiu-Min Li
Recruiting
Remifentanil in Adults With OSA

Condition: Apnea, Sleep
Intervention: Drug: Targeted infusion of remifentanil
Sponsor: Washington University School of Medicine
Recruiting
Effect of the Membrane Blue Dual® Dye on the Retinal Sensitivity in Macular Hole Surgery

Condition: Macular Hole Surgery
Intervention:
Sponsor: Fondation Ophtalmologique Adolphe de Rothschild
Recruiting
The Acute Impact of Sit-stand Desks on Post-meal Blood Sugar Levels

Conditions: Insulin Sensitivity; Glucose Tolerance; Sedentary Behaviour; Physical Activity
Interventions: Behavioral: Sit-stand desk; Behavioral: Sitting desk
Sponsor: University of Prince Edward Island
Recruiting
Visual Perception in Preterm Infants

Condition: Pediatrics
Interventions: Behavioral: collection data; Behavioral: IRM
Sponsor: University Hospital, Strasbourg, France
Recruiting
Study on the Treatment of Bronchial Asthma With Traditional Chinese Medicine

Condition: Bronchial Asthma
Interventions: Drug: Ke Chuan Liu Wei Mixture; Drug: Chuan Xiong Ping Chuan Mixture; Drug: Xie Wu Capsule; Drug: Dan Ma Jia Tablet; Drug: Zhi Chuan Capsule; Drug: Bu Shen Na Qi Granule; Drug: Ke Chuan Liu Wei Mixture placebo; Drug: Chuan Xiong Ping Chuan Mixture placebo; Drug: Xie Wu Capsule placebo; Drug: Dan Ma Jia Tablet placebo; Drug: Zhi Chuan Capsule placebo; Drug: Bu Shen Na Qi Granule placebo
Sponsor: Shanghai University of Traditional Chinese Medicine
Not yet recruiting
Status Asthmaticus on the Intensive Care Prospective - STATIC PRO

Condition: Childhood Asthma With Status Asthmaticus
Intervention:
Sponsors: Erasmus Medical Center; Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA); Radboud University; Maasstad Hospital; VU University Medical Center; UMC Utrecht; University Medical Center Groningen; Amphia Hospital; Rijnstate Hospital; Tergooi Hospital; Maastricht University Medical Center; Leiden University Medical Center
Recruiting
An Imaging Study Using PET/CT to Characterize the Effect of Intravenous Reslizumab on Airway Inflammation

Condition: Asthma
Interventions: Drug: Reslizumab; Drug: Fludeoxyglucose F 18 (FDG); Drug: Placebo
Sponsor: Teva Branded Pharmaceutical Products, R&D Inc.
Recruiting
Effects of Broccoli Sprout Extract on Allergy Rhinitis

Condition: Rhinitis,Allergic
Interventions: Dietary Supplement: Broccoli Sprout Extract; Drug: fluticasone nasal; Dietary Supplement: brocooli sprout extract placebo; Drug: normal saline nasal spray
Sponsor: VA Office of Research and Development
Recruiting
3D Phase Sensitive Inversion Recuperation MRI to Detect and Characterize Multiple Sclerosis Spinal Cord Lesions

Condition: Multiple Sclerosis
Intervention:
Sponsor: Fondation Ophtalmologique Adolphe de Rothschild
Recruiting
A Randomized Multicenter Study for Isolated Skin Vasculitis

Conditions: Primary Cutaneous Vasculitis; Cutaneous Polyarteritis Nodosa; IgA Vasculitis; Henoch-Schönlein Purpura
Interventions: Drug: Colchicine; Drug: Dapsone; Drug: Azathioprine
Sponsors: University of Pennsylvania; National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS); National Center for Advancing Translational Science (NCATS); Office of Rare Diseases (ORD)
Recruiting
Combination Chemotherapy in Treating Young Patients With Newly Diagnosed High-Risk B Acute Lymphoblastic Leukemia and Ph-Like TKI Sensitive Mutations

Conditions: B Acute Lymphoblastic Leukemia; Central Nervous System Leukemia; Ph-Like Acute Lymphoblastic Leukemia; Testicular Leukemia; Untreated Adult Acute Lymphoblastic Leukemia; Untreated Childhood Acute Lymphoblastic Leukemia
Interventions: Drug: Clofarabine; Drug: Cyclophosphamide; Drug: Cytarabine; Drug: Dasatinib; Drug: Dexamethasone; Drug: Doxorubicin Hydrochloride; Drug: Etoposide; Drug: Hydrocortisone Sodium Succinate; Other: Laboratory Biomarker Analysis; Drug: Leucovorin Calcium; Drug: Mercaptopurine; Drug: Methotrexate; Drug: Pegaspargase; Drug: Prednisone; Radiation: Radiation Therapy; Drug: Thioguanine; Drug: Vincristine Sulfate
Sponsor: National Cancer Institute (NCI)
Recruiting
Effects of Exercise Training Intensity on Fitness and Insulin Sensitivity in African Americans

Conditions: Obesity; Insulin Resistance; Sedentary Lifestyle
Interventions: Behavioral: Moderate intensity exercise training (MOD-INT); Behavioral: High Intensity exercise training (HI-INT)
Sponsor: East Carolina University
Recruiting
Hormone Therapy With or Without Definitive Radiotherapy in Metastatic Prostate Cancer

Condition: Prostate Cancer
Interventions: Radiation: Radiotherapy to the pelvis; Drug: Hormonal therapy (LHRH agonist and/or antiandrogens)
Sponsor: University Hospital "Sestre Milosrdnice"
Recruiting
A Phase III Parallel Group Study, Comparing the Efficacy, Safety and Tolerability of the Fixed Dose Combination (FDC) of Fluticasone Furoate+Umeclidinium Bromide+Vilanterol (FF/UMEC/VI) With the FDC of FF/VI in Subjects With Inadequately Controlled Asthma

Condition: Asthma
Interventions: Drug: FF/UMEC/VI (100/31.25/25) mcg; Drug: FF/UMEC/VI (100/62.5/25) mcg; Drug: FF/UMEC/VI (200/31.25/25) mcg; Drug: FF/UMEC/VI (200/62.5/25) mcg; Drug: FF/VI (100/25) mcg; Drug: FF/VI (200/25) mcg; Drug: Fluticasone/salmeterol (FSC); Drug: Albuterol/salbutamol; Device: ELLIPTA DPI; Device: DISKUS DPI; Device: METERED-DOSE INHALER (MDI)
Sponsor: GlaxoSmithKline
Recruiting
Safety and Efficacy Study of Topically Applied DS107 Cream in Mild to Moderate Atopic Dermatitis Patients

Condition: Atopic Dermatitis
Interventions: Drug: DS107; Other: Vehicle cream
Sponsor: DS Biopharma
Recruiting
Trial on Vascular Inflammation in Atopic Dermatitis

Conditions: Atopic Dermatitis; Vascular Inflammation; Coronary Atherosclerosis
Interventions: Other: FDG-PET Scan; Other: MDCT; Other: biopsy and blood collection
Sponsors: Innovaderm Research Inc.; Montreal Heart Institute; Icahn School of Medicine at Mount Sinai
Recruiting
A Study to Evaluate Safety, Tolerability and Immune Response in Adults Allergic to Peanut After Receiving Intradermal or Intramuscular Administration of ASP0892 (ARA-LAMP-vax), a Single Multivalent Peanut (Ara h1, h2, h3) Lysosomal Associated Membrane Protein DNA Plasmid Vaccine

Condition: Peanut Allergy
Interventions: Drug: ASP0892 Intradermal; Drug: ASP0892 Intramuscular; Drug: Placebo Intradermal; Drug: Placebo Intramuscular
Sponsor: Astellas Pharma Global Development, Inc.
Recruiting
Effects of Low-Level Laser Stimulation With and Without Fear Extinction Training

Conditions: Phobias; Claustrophobia; Social Phobia
Interventions: Behavioral: Extinction Training; Device: Low-Level Laser Therapy; Device: Sham Low-Level Laser Therapy
Sponsor: University of Texas at Austin
Recruiting
Phase I/II Study of CK-101 in NSCLC Patients and Other Advanced Solid Tumors

Conditions: Lung Neoplasms; Carcinoma, Non-Small-Cell Lung; Neoplasms; Lung Diseases; Adenocarcinoma; Advanced Solid Tumors
Intervention: Drug: CK-101
Sponsor: Checkpoint Therapeutics, Inc.
Recruiting
Narrowband Ultraviolet B Versus Narrowband Ultraviolet B Plus Ultraviolet A1 for Atopic Eczema

Condition: Atopic Eczema
Intervention: Radiation: combined ultraviolet phototherapy (NB-UVB + UVA1) vs. NB-UVB monotherapy
Sponsors: University of Dundee; NHS Tayside
Recruiting
Electronic Monitoring of Medication Adherence in Moderate to Severe Asthma Patients

Condition: Asthma
Intervention: Behavioral: Electronic sensor and OW education
Sponsors: Montefiore Medical Center; Stony Wold-Herbert Fund, Inc.
Recruiting
Clinical Response to Rhinovirus Challenge

Conditions: Asthma; Allergic Rhinitis
Intervention: Biological: Rhinovirus (GMP RV16 HRV-16)
Sponsors: University of Virginia; National Institutes of Health (NIH); National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting
The Mammography and Ultrasonography STudy for Breast Cancer Screening Effectiveness

Conditions: Invasive Cancer; Ductal Carcinoma in Situ
Interventions: Device: Ultrasonography; Device: Digital mammography
Sponsors: Soonchunhyang University Hospital; Ministry of Health & Welfare, Korea
Recruiting
Topical NanoDox® for Atopic Dermatitis

Condition: Dermatitis, Atopic
Intervention: Drug: Nanodox 1% (doxycycline monohydrate hydrogel)
Sponsors: University of Florida; Alchem Laboratories, Inc
Recruiting
Influence of Central Nervous Insulin Sensitivity on Insulin Secretion

Condition: Insulin Secretion
Interventions: Drug: intranasal insulin; Drug: Placebo
Sponsor: University Hospital Tuebingen
Recruiting
Structural and Functional Brain Reorganization in Neuropathic Pain. Influences of the Loss of Sensitivity and the Atrophy Cortical on Activations Due to Stimulation Allodynic

Condition: Neuropathic Pain
Interventions: Other: stimulation on painful area (area allodynic); Other: same stimulation on non-painful area; Radiation: MRI scan
Sponsor: Centre Hospitalier Universitaire de Saint Etienne
Recruiting
Atopic Dermatitis in Atopy Predisposed Infants

Condition: Dermatitis, Atopic
Intervention: Other: standardized skin care regimen
Sponsors: HiPP GmbH & Co. Vertrieb KG; Charite University, Berlin, Germany
Recruiting
Sensitivity of PDL-1-analysis From Pleural Effusion in Non-small Cell Lung Cancer

Condition: Lung Neoplasms
Intervention:
Sponsors: Wissenschaftliches Institut Bethanien e.V; Merck Sharp & Dohme Corp.; Institute of Pathology, University Clinic Düsseldorf
Recruiting
Multi-maintenance Olaparib After Disease Recurrence in Participants With Platinum Sensitive BRCAm High Grade Serous Ovarian Cancer

Condition: Ovarian Cancer
Interventions: Drug: Olaparib; Drug: Cediranib; Drug: Platinum-based Chemotherapy
Sponsor: Rozalia Lubiatowska
Recruiting
Study of QMF149 (150/80 µg) Compared With MF Twisthaler® (200 µg) in Patients With Asthma

Condition: Mild Asthma
Interventions: Drug: QMF149 150/80 μg; Drug: MF 200 μg
Sponsor: Novartis Pharmaceuticals
Recruiting
Efficacy and Safety of Indacaterol Acetate Delivered Via the Concept1 Inhalation Device in Children Greater or Equal to 6 and Less Than 12 Years of Age With Asthma

Condition: Asthma
Interventions: Drug: Indacaterol acetate 75 μg; Drug: Indacaterol acetate 150 μg
Sponsor: Novartis Pharmaceuticals
Recruiting
Effects of a Orally Inhaled Fluticasone Furoate on Growth Velocity in Prepubertal, Paediatric Subjects With Asthma Over a Year

Condition: Asthma
Interventions: Drug: Fluticasone furoate; Drug: Placebo; Drug: Montelukast; Drug: Short Acting Beta 2 Agonist
Sponsor: GlaxoSmithKline
Recruiting
Characterization of Adults for Asthma Microbiome Research Studies

Conditions: Asthma; Healthy
Intervention:
Sponsors: University of Michigan; National Institutes of Health (NIH)
Recruiting
Refractory Asthma Stratification Programme (RASP) Bronchoscopy Study

Condition: Persistent Asthma
Intervention: Procedure: Bronchoscopy
Sponsors: University of Leicester; Genentech, Inc.; Queen's University, Belfast; Medical Research Council
Recruiting
EoE Food Desensitization

Condition: Eosinophilic Esophagitis
Intervention: Other: Oral food desensitization
Sponsor: The University of Texas Health Science Center, Houston
Recruiting
Optimizing Vitamin D Status in Children With Wheeze / Asthma (OPTIVIT)

Conditions: Asthmatic Crisis; Wheezing
Intervention: Dietary Supplement: Fultium-D3 drops (Internis)
Sponsor: Queen Mary University of London
Recruiting
Efficiency of Levamisole for Maintaining Remission After the First Flare of Steroid Sensitive Nephrotic Syndrome in Children

Condition: First Manifestation of Steroid Sensitive Nephrotic Syndrome
Interventions: Drug: Levamisole Hydrochloride; Other: Placebo
Sponsor: Assistance Publique - Hôpitaux de Paris
Not yet recruiting
Phase I, Placebo-Controlled, Blinded Pilot Study of Ipratropium in Children Admitted to the ICU With Status Asthmaticus

Condition: Status Asthmaticus
Interventions: Drug: Ipratropium; Drug: 0.9% Sodium Chloride; Drug: Albuterol; Drug: corticosteroids
Sponsor: University Hospitals Cleveland Medical Center
Recruiting
Evaluating the Safety and Feasibility of TLD for the Treatment of Severe Asthma

Condition: Asthma
Intervention: Device: Targeted Lung Denervation (TLD)
Sponsor: Nuvaira, Inc.
Recruiting
The Effects of Prebiotics on Gut Bacterial Parameters, Immune Function & Exercise-Induced Airway Inflammation.

Conditions: Exercised Induced Asthma; Asthma
Interventions: Dietary Supplement: HOST-DM059; Dietary Supplement: Maltodextrin
Sponsors: Nottingham Trent University; University of Reading; Clasado Biosciences; Imperial College London; HOST Therabiomics; The John van Geest Cancer Research Centre
Recruiting
Digital Action Plan for Asthma Attacks

Condition: Asthma
Interventions: Other: Digital action plan for asthma exacerbations + Written action plan; Other: Written action plan
Sponsor: Assistance Publique - Hôpitaux de Paris
Recruiting
Safety and Efficacy of Three Doses of Oral Fluticasone Propionate in Adults With Eosinophilic Esophagitis

Condition: Eosinophilic Esophagitis
Interventions: Drug: EMS Fluticasone 1; Drug: EMS Fluticasone 2; Drug: EMS Fluticasone 3; Other: EMS Placebo Fluticasone
Sponsor: EMS
Not yet recruiting
Asthma Control Test Guided Treatment in Chinese Subjects

Condition: Bronchial Diseases
Interventions: Drug: ACT guided Routine Treatment; Drug: Routine Treatment
Sponsors: GlaxoSmithKline; Macrostat
Recruiting
A Trial of a Botanical Drug Containing East Indian Sandalwood Oil (EISO) For Treatment of Atopic Dermatitis

Conditions: Atopic Dermatitis; Eczema
Interventions: Drug: SAN007 5% cream; Drug: Placebo; Drug: SAN007 10% cream
Sponsors: Santalis Pharmaceuticals, Inc.; ClinDatrix, Inc.; Texas Dermatology and Laser Specialists; Clinical Trials of Texas, Inc; DermResearch, Inc; Progressive Clinical Research
Recruiting
11C or 18F-Choline PET/CT and Whole Body MRI for Staging and Response Prediction in Metastatic Hormono-Sensitive Prostate Cancer Patients Receiving Enzalutamide

Condition: Prostate Cancer Metastatic
Interventions: Drug: Enzalutamide; Procedure: 11C or 18F-Choline PET/CT; Procedure: Whole body MRI; Procedure: Bone scan
Sponsors: The European Uro-Oncology Group; Centre for Human Drug Research, Netherlands
Recruiting
Efficacy and Safety Study of Orally Administered DS107 in Moderate to Severe Atopic Dermatitis Patients

Condition: Atopic Dermatitis
Interventions: Drug: DS107; Drug: Placebo
Sponsor: DS Biopharma
Recruiting
ODM-201 in Addition to Standard ADT and Docetaxel in Metastatic Castration Sensitive Prostate Cancer

Condition: Prostatic Neoplasms
Interventions: Drug: BAY1841788 / darolutamide (ODM-201); Drug: Standard ADT (androgen deprivation therapy); Drug: Docetaxel; Drug: Placebo
Sponsors: Bayer; Orion Corporation, Orion Pharma
Recruiting
Busonid® (Budesonide 200 mcg and 400 mcg) to Treat Asthma Not Controlled or Partially Controlled

Condition: Asthma
Intervention: Drug: Busonid (budesonide 200mcg and 400mcg)
Sponsor: Ache Laboratorios Farmaceuticos S.A.
Not yet recruiting
ARIEL4: A Study of Rucaparib Versus Chemotherapy BRCA Mutant Ovarian, Fallopian Tube, or Primary Peritoneal Cancer Patients

Conditions: Ovarian Cancer; Epithelial Ovarian Cancer; Fallopian Tube Cancer; Peritoneal Cancer
Interventions: Drug: Chemotherapy; Drug: Rucaparib
Sponsors: Clovis Oncology, Inc.; Foundation Medicine
Recruiting
Determination of Specific Biomarkers of Acute Attack of Angioedema Within Pediatric Population

Conditions: Hereditary Angioedema; Healthy Volunteers
Intervention: Other: blood sample
Sponsor: University Hospital, Grenoble
Recruiting
Stress Sensitivity and Reward Responsivity in Depression

Condition: Depressed
Intervention:
Sponsors: Dr. Kate Harkness; University Health Network, Toronto; University of Calgary; Harvard University; McGill University
Recruiting
Predictors of Positive Food Challenge

Condition: Oral Immunotherapy for Food Allergy
Intervention:
Sponsor: Assaf-Harofeh Medical Center
Recruiting
Experimental Autologous Mesenchymal Stem Cell Therapy in Treatment of Chronic Autoimmune Urticaria

Conditions: Urticaria; Autoimmune Diseases; Immune System Diseases; Skin Diseases
Intervention: Biological: Autologous mesenchymal stem cell
Sponsors: Celal Bayar University; The Scientific and Technological Research Council of Turkey; Acıbadem Labcell
Recruiting
Role of Inflammatory Mediators in AERD

Condition: Asthma, Aspirin-Induced
Intervention: Drug: aspirin
Sponsor: Brigham and Women's Hospital
Recruiting
Association of Transcutaneous Pulse CO-oximetry With Inflammatory Lung Diseases

Conditions: Asthma; Allergic Rhinitis; Cystic Fibrosis; Pneumonia
Intervention:
Sponsor: Boston Children’s Hospital
Recruiting
Three-month, Single-center Study to Identify Biomarkers/Response to Xolair Therapy in Chronic Idiopathic Urticaria

Condition: Chronic Idiopathic Urticaria
Intervention: Biological: Xolair
Sponsors: William Henderson; University of Washington
Recruiting
Functional Medicine in Asthma (FAst) Study

Condition: Asthma
Interventions: Behavioral: Lifestyle Factors; Other: Customized use of Dietary Supplements; Other: Currently Accepted Asthma Care Guidelines
Sponsor: The Cleveland Clinic
Recruiting
Insulin Sensitivity and Secretion During Pregnancy and Post Partum in Women With Gestational Diabetes.

Condition: Diabetes, Gestational
Intervention:
Sponsor: University of Aarhus
Recruiting
HLA-Mismatched Unrelated Donor Bone Marrow Transplantation With Post-Transplantation Cyclophosphamide

Conditions: Myelodysplastic Syndrome (MDS); Chronic Lymphocytic Leukemia (CLL); Chemotherapy-sensitive Lymphoma; Acute Lymphoblastic Leukemia (ALL)/T Lymphoblastic Lymphoma; Acute Myelogenous Leukemia (AML); Acute Biphenotypic Leukemia (ABL); Acute Undifferentiated Leukemia (AUL)
Interventions: Drug: Fludarabine; Drug: Cyclophosphamide 14.5 mg/kg/day IV on Days -6, -5; Radiation: Total Body Irradiation (TBI) 200cGy on Day -1; Procedure: Infusion of non-T-cell depleted bone marrow on Day 0; Drug: Busulfan; Drug: Cyclophosphamide 50mg/kg/day IV on Days -2,-1; Drug: Cyclophosphamide 50mg/kg/day IV on Days -5,-4; Radiation: Total Body Irradiation (TBI) 200cGy twice a day on Days -3, -2, -1; Drug: Post-HCT Cyclophosphamide 50mg/kg IV on Day+3, +4; Drug: Sirolimus; Drug: Mycophenolate mofetil; Drug: G-CSF; Drug: Pre-HCT Mesna on Days -6 and -5; Drug: Pre-HCT Mesna on Days -2 and -1; Drug: Pre-HCT Mesna on Days -5 and -4; Drug: Post-HCT Mesna
Sponsors: Center for International Blood and Marrow Transplant Research; National Marrow Donor Program; Resource for Clinical Investigation in Blood and Marrow Transplantation
Recruiting
Personalized Kinase Inhibitor Therapy Combined With Chemotherapy in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia

Condition: Untreated Adult Acute Myeloid Leukemia
Interventions: Drug: Cytarabine; Drug: Dasatinib; Drug: Idarubicin; Other: Laboratory Biomarker Analysis; Drug: Nilotinib; Drug: Ponatinib Hydrochloride; Drug: Sorafenib Tosylate; Drug: Sunitinib Malate
Sponsors: OHSU Knight Cancer Institute; National Cancer Institute (NCI)
Recruiting
The Role of Filaggrin Mutations and Sensitization Pathways in Allergic Rhinitis and Peanut Allergy

Conditions: Allergic Rhinitis; Peanut Allergies
Intervention:
Sponsor: Queen's University
Recruiting
Validation of the Hospital Asthma Severity Score (HASS)

Condition: Asthma
Intervention: Other: Not an interventional study
Sponsor: Boston Children’s Hospital
Recruiting
Study On Fatigue- And Hand-Foot Syndrome-Related Quality Of Life In Patients With Metastatic Renal Cell Carcinoma Receiving A Tyrosine Kinase Inhibitor as First-Line Treatment

Condition: Metastatic Renal Cell Carcinoma
Intervention:
Sponsors: Pfizer; TFS Trial Form Support
Recruiting
SOFEED: Six Food vs. One Food Eosinophilic Esophagitis Diet Study

Conditions: Eosinophilic Gastrointestinal Disorders (EGIDs); Eosinophilic Esophagitis (EoE)
Interventions: Other: elimination diet therapy; Drug: Flovent
Sponsors: Children's Hospital Medical Center, Cincinnati; National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); National Institute of Allergy and Infectious Diseases (NIAID); Office of Rare Diseases (ORD); National Center for Advancing Translational Science (NCATS)
Recruiting
Comparison of Vibrating Mesh Nebulizer Versus Jet Nebulizer in the Pediatric Asthma Patient a Randomized Controlled Trial

Condition: Asthma
Intervention:
Sponsor: University of Texas Southwestern Medical Center
Recruiting
Developing Optimal Parameters for Hyperpolarized Noble Gas and Inert Fluorinated Gas MRI of Lung Disorders

Conditions: Lung Transplant; Lung Resection; Lung Cancer; Asthma; Cystic Fibrosis; Chronic Obstructive Pulmonary Disease; Emphysema; Mesothelioma; Asbestosis; Pulmonary Embolism; Interstitial Lung Disease; Pulmonary Fibrosis; Bronchiectasis; Seasonal Allergies; Cold Virus; Lung Infection; Pulmonary Hypertension; Pulmonary Dysplasia; Obstructive Sleep Apnea
Interventions: Drug: HP 3He; Drug: HP 129Xe; Drug: PFP; Drug: SF6; Device: 129Xe Small and Large Human Lung Coil; Device: 3He Human Lung Coil; Device: PFP and SF6 Human Lung Coil
Sponsors: Thunder Bay Regional Research Institute; Thunder Bay Regional Health Sciences Centre; St. Joseph's Care Group; Lakehead University
Not yet recruiting
Eosinophil β1 Integrin Activation as a Biomarker for Eosinophilic Esophagitis

Condition: Eosinophilic Esophagitis
Intervention: Other: Observation Period
Sponsors: University of Wisconsin, Madison; National Institutes of Health (NIH); National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting
Study of Pregnancy Regulation of Insulin and Glucose

Condition: Gestational Diabetes Mellitus
Intervention: Other: Oral glucose tolerance test
Sponsor: Massachusetts General Hospital
Recruiting
Observational Study of Obstructive Lung Disease (NOVELTY)

Conditions: Asthma; COPD; Chronic Obstructive Pulmonary Disease
Interventions: Procedure: Blood draw; Procedure: Urine; Procedure: Lung function measurements; Procedure: Fractional Exhaled Nitric Oxide (FENO)
Sponsors: AstraZeneca; Parexel
Recruiting
AIRWEIGHS: Investigating Obesity as a Susceptibility Factor for Air Pollution in Childhood Asthma

Condition: Asthma
Interventions: Device: Active Air Purifier; Device: Placebo Air Purifier
Sponsor: Johns Hopkins University
Recruiting
Prescribing Asthma Controller Medication According to Gene Status to Improve Quality of Life in Young People With Asthma

Condition: Asthma
Interventions: Genetic: Personalised medicine (Salmeterol); Genetic: Personalised medicine (Montelukast); Other: Standard care
Sponsor: University of Sussex
Recruiting
Sensitive Troponin I in Out-of-hospital Cardiac Arrest

Conditions: Cardiac Arrest; Acute Coronary Lesion; Stable Obstructive Coronary Disease; Non-obstructive Coronary Disease
Intervention: Other: Blood sample collection
Sponsor: University Medical Centre Ljubljana
Recruiting
Telemedicine Enhanced Asthma Management Through the Emergency Department

Condition: Asthma
Interventions: Other: TEAM-ED; Other: Enhanced Usual Care
Sponsor: University of Rochester
Recruiting
The Role of Endothelium A and EGFR Receptor in Fibrocytes From Asthma With Obstructive Sleep Apnea

Conditions: Asthma; OSA
Intervention: Device: continuous positive airway pressure (CPAP)
Sponsors: Chang Gung Memorial Hospital; Ministry of Science and Technology, Taiwan
Recruiting
GL-ONC1 Oncolytic Immunotherapy in Patients With Recurrent Ovarian Cancer

Conditions: Ovarian Cancer; Peritoneal Carcinomatosis; Fallopian Tube Cancer
Intervention: Biological: GL-ONC1
Sponsor: Genelux Corporation
Recruiting
A Study to Evaluate the Safety and Efficacy of PAC-14028 Cream in Pediatric Atopic Dermatitis

Condition: Atopic Dermatitis
Interventions: Drug: PAC-14028 Cream 0.1%; Drug: PAC-14028 Cream 0.3%; Drug: PAC-14028 Cream 1.0%; Drug: PAC-14028 Cream Vehicle
Sponsor: Amorepacific Corporation
Recruiting
Study Of PF-06817024 In Healthy Subjects, In Patients With Chronic Rhinosinusitis With Nasal Polyps And in Patients With Atopic Dermatitis

Conditions: Healthy; Chronic Rhinosinusitis With Nasal Polyps; Atopic Dermatitis
Interventions: Biological: PF-06817024; Other: Placebo for PF-06817024
Sponsor: Pfizer
Recruiting
The Phthalate-Allergen Immune Response Study

Condition: Allergies
Interventions: Other: Phthalate; Other: Filtered Air; Other: Allergen
Sponsor: University of British Columbia
Recruiting
Biomarkers of Irritant-Induced and Allergic Asthma

Condition: Asthma
Interventions: Drug: Fluticasone propionate HFA 220; Drug: Placebo
Sponsor: New York University School of Medicine
Recruiting
Effect of Gymnema Sylvestre on Patients With Impaired Glucose Tolerance.

Condition: Impaired Glucose Tolerance
Interventions: Drug: Gymnema Sylvestre; Drug: Placebo
Sponsor: University of Guadalajara
Recruiting
The Potential of Carnosine Supplementation in Reducing the Cardiometabolic Risk

Condition: Insulin Sensitivity
Interventions: Dietary Supplement: carnosine; Other: Placebo
Sponsor: Monash University
Recruiting
Improving Asthma Care by Partnering With School Nurses to Bring Asthma Care Into the Inner-City Schools

Condition: Asthma
Interventions: Device: Sensor cap system for inhalers; Other: App for SmartPhone; Behavioral: Motivational interviews; Other: Telehealth clinic visits
Sponsors: Children's Hospital Medical Center, Cincinnati; Verizon Foundation; Luther Foundation
Recruiting
An Extension Study to Evaluate Maintenance of Efficacy and Long-term Treatment Effect of Oral Budesonide Suspension (OBS) in Adults and Adolescents With Eosinophilic Esophagitis (EoE)

Condition: Eosinophilic Esophagitis (EoE)
Interventions: Drug: Oral Budesonide Suspension (OBS); Drug: Placebo
Sponsor: Shire
Recruiting
Gut Permeability Assessment in Celiac and Gluten Sensitive Children

Condition: Celiac Disease
Intervention:
Sponsor: Mayo Clinic
Recruiting
Mitochondrial Function in Circulating Cells and Muscle Tissue

Conditions: Healthy; Obesity; Insulin Sensitivity; Women
Intervention:
Sponsors: University of Arkansas; Arkansas Children's Hospital Research Institute
Recruiting
Behavioral Activation Therapy for Smoking Cessation

Conditions: Cancer Prevention; Tobacco Use Cessation
Interventions: Behavioral: Questionnaires; Behavioral: CO Level Testing; Behavioral: Behavior Activation Treatment (BAT); Behavioral: Standard Cessation (SC); Drug: Nicotine Patch; Behavioral: Cotinine Level Testing; Procedure: Lab Session
Sponsors: M.D. Anderson Cancer Center; National Institute on Drug Abuse (NIDA)
Recruiting
Healthy Caregivers-Healthy Children (HC2) Phase II

Conditions: Pediatric Obesity; Obesity
Interventions: Behavioral: Healthy Caregivers- Healthy Children Toolkit; Behavioral: Safety Curriculum
Sponsor: University of Miami
Recruiting
Personalized Patient Derived Xenograft (pPDX) Modeling to Test Drug Response in Matching Host

Conditions: Colorectal Neoplasms; Colorectal Cancer; Breast Cancer; Breast Neoplasms; Ovarian Cancer; Ovarian Neoplasm
Intervention: Other: Molecular Profiling & In Vivo drug testing in pPDX and organoid cultures
Sponsor: University Health Network, Toronto
Recruiting
Trial Evaluating Maintenance Olaparib in Patients With Platinum-sensitive Advanced Non-small Cell Lung Cancer

Condition: Non Small Cell Lung Cancer
Interventions: Drug: Olaparib; Drug: Placebo
Sponsor: Gustave Roussy, Cancer Campus, Grand Paris
Recruiting
Investigate the Effect of the CREON2000A on Asthma Control in Children With Mild to Moderate Persistent Asthma

Condition: Asthma
Interventions: Device: CREON2000A; Device: Sham
Sponsors: General Innovations and Goods, Inc.; National Institute of Allergy and Infectious Diseases (NIAID); University of Cincinnati; Bernstein Clinical Research Center
Recruiting
Spectacle Tints and Thin-Films for Migraine

Condition: Headache Migraine Chronic
Interventions: Device: Gray tinted spectacle lenses; Device: Thin-Film spectacle lenses
Sponsors: University of Utah; Axon Optics, LLC; Mayo Clinic; Brigham and Women's Hospital; Northwell Health
Recruiting
Childhood Asthma Perception Study

Conditions: Asthma; Childhood Asthma
Interventions: Behavioral: PEF Feedback; Behavioral: Control Feedback
Sponsors: Albert Einstein College of Medicine, Inc.; National Heart, Lung, and Blood Institute (NHLBI)
Recruiting
Intralymphatic Immunotherapy for House Dust Mite, Dog, and Cat Allergy Using Tyrosine S® in Allergic Rhinitis

Condition: Allergic Rhinitis
Interventions: Biological: ILIT with extract of causal allergen; Biological: ILIT with normal saline; Drug: Rescue medication for allergic rhinitis
Sponsors: Gachon University Gil Medical Center; Korea Research Foundation
Recruiting
Pre-operative Carbohydrate Drink to Preserve Peri-operative Insulin Sensitivity

Condition: Laparoscopic Abdominal Surgery
Interventions: Dietary Supplement: simple carbohydrate drink; Dietary Supplement: complex carbohydrate drink
Sponsors: McGill University Health Center; Mitacs; Medtronic - MITG
Recruiting
Dose Finding for the Treatment of Rhinitis/Rhinoconjunctivitis Against Mite Allergy

Conditions: Rhinitis; Rhinoconjunctivitis
Interventions: Biological: MM09 Mannosylated 5.000 subcutaneous; Biological: MM09 Mannosylated 10.000 subcutaneous; Biological: MM09 Mannosylated 30.000 subcutaneous; Biological: MM09 Mannosylated 50.000 subcutaneous; Biological: MM09 Mannosylated 5.000 sublingual; Biological: MM09 Mannosylated 10.000 sublingual; Biological: MM09 Mannosylated 30.000 sublingual; Biological: MM09 Mannosylated 50.000 sublingual; Biological: Subcutaneous placebo; Biological: Sublingual placebo
Sponsor: Inmunotek S.L.
Recruiting
HIRREM Developmental Study

Conditions: Sleep Initiation and Maintenance Disorders; Anxiety; Post-Traumatic Stress Disorder; Hot Flashes; Headache; Traumatic Brain Injury; Post Concussion Symptoms
Intervention: Device: HIRREM
Sponsor: Wake Forest University Health Sciences
Recruiting
Dose Finding for the Treatment of Rhinitis/Rhinoconjunctivitis Against Grass Pollen Allergy

Conditions: Rhinitis; Rhinoconjunctivitis
Interventions: Biological: MG56 Mannosylated 60 subcutaneous; Biological: MG56 Mannosylated 100 subcutaneous; Biological: MG56 Mannosylated 300 subcutaneous; Biological: MG56 Mannosylated 500 subcutaneous; Biological: MG56 Mannosylated 60 sublingual; Biological: MG56 Mannosylated 100 sublingual; Biological: MG56 Mannosylated 300 sublingual; Biological: MG56 Mannosylated 500 sublingual; Biological: Subcutaneous placebo; Biological: Sublingual placebo
Sponsor: Inmunotek S.L.
Recruiting
Accelerated Rule Out of Myocardial Infarction

Condition: Myocardial Infarction
Intervention: Procedure: Accelerated, combined biomarker rule-out strategy for MI
Sponsor: Aarhus University Hospital Skejby
Recruiting
Effects of an Exercise Program for Children With Asthma

Condition: Asthma
Intervention: Other: Exercise program
Sponsor: Universidad Europea de Madrid
Recruiting
Cutaneous Microcirculation and Nervous Sensitivity in Psoriasis

Condition: Psoriasis
Interventions: Other: Acetylcholine iontophoresis; Other: Sodium Nitroprussiate iontophoresis; Other: ppi water iontophoresis; Other: Laser Doppler recording
Sponsor: Hospices Civils de Lyon
Recruiting
Vitamin D to Prevent Severe Asthma Exacerbations (Vit-D-Kids Asthma)

Condition: Asthma
Interventions: Drug: vitamin D3 4000 IU; Drug: Placebo
Sponsors: Juan Celedon, MD; Pharmavite; National Heart, Lung, and Blood Institute (NHLBI)
Recruiting
Docetaxel and PROSTVAC for Metastatic Castration-Sensitive Prostate Cancer

Conditions: Prostate Cancer; Prostate Neoplasms; Neoplasms, Prostatic
Interventions: Biological: PROSTVAC-V; Biological: PROSTVAC-F; Drug: Docetaxel
Sponsor: National Cancer Institute (NCI)
Recruiting
Replacing Refined Carbohydrates With Healthy Fats on Cardio-metabolic Markers

Conditions: Pre-diabetes; Metabolic Syndrome
Interventions: Dietary Supplement: Active; Dietary Supplement: Control
Sponsor: Institute for Food Safety and Health, United States
Recruiting
Trauma-Sensitive Yoga for Female Veterans With PTSD Who Experienced Military Sexual Trauma

Condition: Stress Disorders, Post-traumatic
Interventions: Behavioral: Trauma Sensitive Yoga Intervention; Behavioral: Cognitive Processing Therapy-Cognitive Only
Sponsor: VA Office of Research and Development
Recruiting
Identification of Epidermal Signatures in Patients With Atopic Dermatitis

Condition: Atopic Dermatitis
Interventions: Procedure: Skin Biopsy; Procedure: Skin tape stripping; Procedure: Blood draw
Sponsors: National Jewish Health; MedImmune LLC
Recruiting
Effect of OC459 on the Response to Rhinovirus Challenge in Asthma

Conditions: Asthma; Rhinovirus; Picornaviridae Infections; Common Cold
Interventions: Drug: OC459; Drug: Placebo; Other: Rhinovirus
Sponsors: Imperial College London; Medical Research Council; Atopix Therapeutics, Ltd.
Recruiting
Differential Sensitivity Markers in Youth Drug Abuse Prevention

Condition: Adolescent Substance Use
Interventions: Behavioral: Teen Intervene; Behavioral: Everyday Parenting
Sponsors: University of Minnesota - Clinical and Translational Science Institute; National Institute on Drug Abuse (NIDA); Natalis Counseling Center
Recruiting
Carboplatin and Gemcitabine Hydrochloride With or Without ATR Kinase Inhibitor VX-970 in Treating Patients With Recurrent and Metastatic Ovarian, Primary Peritoneal, or Fallopian Tube Cancer

Conditions: High Grade Ovarian Serous Adenocarcinoma; Ovarian Endometrioid Tumor; Recurrent Fallopian Tube Carcinoma; Recurrent Ovarian Carcinoma; Recurrent Primary Peritoneal Carcinoma; Stage IV Fallopian Tube Cancer AJCC v6 and v7; Stage IV Ovarian Cancer AJCC v6 and v7; Stage IV Primary Peritoneal Cancer AJCC v7
Interventions: Drug: ATR Kinase Inhibitor VX-970; Drug: Carboplatin; Drug: Gemcitabine Hydrochloride; Other: Laboratory Biomarker Analysis; Other: Pharmacological Study
Sponsor: National Cancer Institute (NCI)
Recruiting
Assessment of Immediate Adverse Reactions From Dotarem in Children Under 2 Years of Age

Conditions: Adverse Reaction to Drug; Allergic Reaction to Contrast Media
Intervention: Drug: Gadoteric Acid
Sponsor: St. Louis University
Recruiting
Platinum Rechallenge in Patients With Platinum-sensitive mTNBC

Condition: Metastatic Breast Cancer
Interventions: Drug: Vinorelbine; Drug: DDP
Sponsor: Fudan University
Recruiting
Sensitivity of Pharmacokinetics to Differences in Particle Size Distribution of Suspension-based Nasal Sprays

Condition: Hypersensitivity
Interventions: Drug: Mometasone furoate drug formulation (MFF) 1; Drug: Mometasone furoate drug formulation (MFF) 2
Sponsors: University of Florida; Food and Drug Administration (FDA)
Not yet recruiting
Longitudinal Observational Study in Prematurely Born Preschool Children: Assessment of Lung Function Parameters

Conditions: Asthma; Allergic Rhinitis
Intervention: Other: Lung Function Assessment
Sponsor: Stefania La Grutta, MD
Recruiting
Asthma Exacerbations and Vascular Function

Condition: Asthma
Interventions: Drug: Mannitol; Drug: Methacholine; Drug: Placebo; Other: Rest; Other: Exercise
Sponsor: University of Alberta
Recruiting
Evaluation of the Sensitivity of Endoscopy to Detect Nasopharyngeal Carcinoma (NPC) in an Epstein-Barr Virus (EBV)-Based NPC Screening Project in China

Condition: Nasopharyngeal Cancinoma (NPC)
Intervention:
Sponsor: National Cancer Institute (NCI)
Recruiting
The Topical Application of Vitamin B6 in Palmar-Plantar Erythrodysesthesia

Condition: Palmar-Plantar Erythrodysesthesia
Interventions: Device: Vitamin B6 cream; Device: Placebo Vitamin B6 cream
Sponsors: Cyprus University of Technology; American Medical Center
Recruiting
REGorafenib vsTamoxifen in Patients With Platinum-sensitive OVARian Carcinoma and Isolated Biological Progression

Condition: Ovarian Carcinoma
Interventions: Drug: Tamoxifen; Drug: Regorafenib
Sponsors: ARCAGY/ GINECO GROUP; Bayer
Recruiting
Bronchial Thermoplasty for Severe Asthma With Dynamic Hyperinflation

Conditions: Asthma; Hyperinflation
Intervention: Procedure: Bronchial thermoplasty for treatment of severe asthma
Sponsor: University Hospital, Toulouse
Recruiting
Oxaliplatin Microdosing Assay in Predicting Exposure and Sensitivity to Oxaliplatin-Based Chemotherapy

Condition: Colon Adenocarcinoma
Interventions: Drug: Carbon C 14 Oxaliplatin; Drug: Oxaliplatin
Sponsors: University of California, Davis; National Cancer Institute (NCI)
Recruiting
PIERS and BIS, sFIT:PIGF, Adrenomedullin

Condition: Eclampsia
Intervention:
Sponsor: Medical University of Graz
Recruiting
A Placebo- Controlled Study in Adolescents and Adults With Eosinophilic Esophagitis (EoE) Measuring Histologic Response and Determine if Reduction in Dysphagia is Achieved

Condition: Eosinophilic Esophagitis (EoE)
Interventions: Drug: OBS; Drug: Placebo
Sponsor: Shire
Recruiting
Cytosponge and Dietary Therapy in EoE

Condition: Eosinophilic Esophagitis
Interventions: Device: Cytosponge; Other: Diet; Other: Phone call; Other: EEsAI Pro
Sponsor: Mayo Clinic
Recruiting
Vasculitis Pregnancy Registry

Conditions: Vasculitis; Behcet's Disease; CNS Vasculitis; Cryoglobulinemic Vasculitis; Eosinophilic Granulomatosis With Polyangiitis (EGPA); Churg-Strauss Syndrome (CSS); Granulomatosis With Polyangiitis (GPA); Wegener's Granulomatosis; IgA Vasculitis; Henoch-Schoenlein Purpura (HSP); Microscopic Polyangiitis (MPA); Polyarteritis Nodosa (PAN); Takayasu Arteritis (TAK); Urticarial Vasculitis; Systemic Vasculitis
Intervention: Other: Online questionnaires
Sponsors: University of Pennsylvania; Duke University; University of South Florida
Recruiting
Sanfu Herbal Patch and Sanfu Moxibustion for Persistent Allergic Rhinitis: a Controlled Clinical Trial

Conditions: Patch,Chinese Herb; Moxibustion; Allergic Rhinitis
Interventions: Drug: Sanfu herbal patch; Drug: Sanfu moxibustion; Drug: Sanfu herbal patch and moxibustion
Sponsor: Hubei Provincial Collaborative Innovation Center of Preventive Treatment by Acupuncture and Moxibust
Recruiting
Bathing Additives in Pediatric Atopic Dermatitis

Condition: Dermatitis, Atopic
Intervention: Other: Bathing Additive
Sponsor: Mayo Clinic
Recruiting
Dietary Factors and Disfluency: A Look Into Food Allergies and Other Environmental Triggers Associated With Variations in Severity of Vocal Cord Tension.

Conditions: Vocal Cord Tension; Dysfluency Developmental
Intervention: Other: Food Allergy Testing and Elimination Diet
Sponsor: The R2 Institute
Not yet recruiting
High Throughput Drug Sensitivity Assay and Genomics- Guided Treatment of Patients With Relapsed or Refractory Acute Leukemia

Conditions: Acute Leukemia of Ambiguous Lineage; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Acute Myeloid Leukemia; Recurrent Childhood Acute Lymphoblastic Leukemia; Recurrent Childhood Acute Myeloid Leukemia; Refractory Acute Myeloid Leukemia; Refractory Adult Acute Lymphoblastic Leukemia; Refractory Childhood Acute Lymphoblastic Leukemia
Interventions: Other: Chemosensitivity Assay; Other: Cytology Specimen Collection Procedure; Genetic: Gene Expression Analysis; Genetic: Genetic Variation Analysis; Drug: In Vitro Sensitivity-Directed Chemotherapy
Sponsors: University of Washington; National Cancer Institute (NCI)
Recruiting
Investigation of Cannabinoid Receptor Agonist Dronabinol in Patients With Functional Chest Pain

Condition: Esophageal Diseases
Interventions: Drug: Dronabinol; Drug: Placebo
Sponsor: Temple University
Recruiting
Post-marketing Safety Surveillance of Breviscapine Powder-Injection : a Registry Study

Conditions: Adverse Drug Event; Adverse Drug Reaction; Chinese Medicine; Anaphylactic Reaction
Intervention: Drug: Breviscapine Powder-Injection
Sponsor: Zhong Wang
Recruiting
Preventing Asthma in High Risk Kids

Condition: Asthma
Interventions: Drug: Omalizumab; Drug: Placebo
Sponsor: Wanda Phipatanakul
Not yet recruiting
Study to Compare the Efficacy and Safety of QVM149 With QMF149 in Patients With Asthma

Condition: Asthma
Interventions: Drug: QVM149; Drug: QMF149; Drug: salmeterol/fluticasone
Sponsor: Novartis Pharmaceuticals
Recruiting
Immune Interactions in Severe Asthma

Condition: Asthma
Intervention: Other: 1 year Observational Follow-up
Sponsor: University of Pittsburgh
Recruiting
Implantable Microdevice for In Vivo Drug Sensitivity Testing in Patients With Early Stage, HER2-Positive or Triple Negative Breast Cancer

Condition: Breast Cancer
Interventions: Device: KIBUR MICRODEVICE; Drug: anthracycline and taxane based chemotherapy
Sponsor: Memorial Sloan Kettering Cancer Center
Recruiting
Study of Efficacy and Safety of QAW039 in Patients With Severe Asthma Inadequately Controlled With Standard of Care Asthma Treatment.

Condition: Asthma
Interventions: Drug: QAW039; Drug: Placebo
Sponsor: Novartis Pharmaceuticals
Recruiting
Effect of OC000459 on Eosinophilic Airway Inflammation in Severe Asthma

Condition: Severe Eosinophilic Asthma
Interventions: Drug: OC000459; Drug: Placebo
Sponsor: Atopix Therapeutics, Ltd.
Recruiting
Cessation Versus Continuation of Long-term Mepolizumab in Severe Eosinophilic Asthma Patients

Condition: Asthma
Interventions: Biological: Mepolizumab 100mg; Drug: Placebo
Sponsor: GlaxoSmithKline
Recruiting
Study of Efficacy and Safety of QAW039 in Patients With Severe Asthma Inadequately Controlled With Standard of Care Asthma Treatment.

Condition: Asthma
Interventions: Drug: QAW039; Drug: Placebo
Sponsor: Novartis Pharmaceuticals
Recruiting
Fatty Acid Oxidation Defects and Insulin Sensitivity

Conditions: Very Long-chain Acyl-CoA Dehydrogenase Deficiency; Trifunctional Protein Deficiency; Long-chain 3-hydroxyacyl-CoA Dehydrogenase Deficiency; Medium-chain Acyl-CoA Dehydrogenase Deficiency; Normal Volunteers
Interventions: Drug: Intralipid/Heparin; Drug: Glycerol/Saline; Drug: Hyperinsulinemic euglycemic clamp
Sponsor: Oregon Health and Science University
Recruiting
Natural History and Genetics of Food Allergy and Related Conditions

Conditions: Food Allergy; Loeys-Dietz Syndrome
Intervention:
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting
A Multicenter Randomized 52 Week Treatment Double-blind, Triple Dummy Parallel Group Study to Assess the Efficacy and Safety of QMF149 Compared to Mometasone Furoate in Patients With Asthma

Condition: Asthma
Interventions: Drug: QMF149; Drug: MF 400; Drug: salmeterol /fluticasone
Sponsor: Novartis Pharmaceuticals
Recruiting
The Significance of Blood-tryptase and c-Kit Mutation in Insect Venom Immunotherapy

Conditions: Hypersensitivity, Immediate; Insect Bites and Stings; Mastocytosis
Intervention:
Sponsor: Meir Medical Center
Recruiting
Pilot Study on Traditional Chinese Medicine and Food Allergy

Conditions: Allergy to Fish; Allergy to Shrimp; Allergy to Crab
Interventions: Dietary Supplement: Treatment - Chinese Herbal Formula - X; Dietary Supplement: Placebo
Sponsors: Hong Kong Sanatorium & Hospital; Chinese University of Hong Kong
Recruiting
PRAgmatic Trial in Atopic Dermatitis Testing Long-term Control Effectiveness of New Phototherapy Regimen During Winter Coupled With Oral Vitamin D Supplementation vs. Placebo

Condition: Atopic Dermatitis
Interventions: Drug: Cholecalciferol; Drug: Placebo of cholecalciferol
Sponsor: Rennes University Hospital
Recruiting
The Research of Standard Diagnosis and Treatment for Severe HSP in Children

Condition: Henoch-Schoenlein Purpura
Interventions: Drug: Dexamethasone; Drug: Gamma globulin; Procedure: Hemoperfusion
Sponsor: Nanjing Children's Hospital
Recruiting
Pediatric Arm of DZL All Age Asthma Cohort

Conditions: Asthma; Wheeze; Hypersensitivity; Endophenotype
Intervention:
Sponsors: Klinikum der Universitaet Muenchen; German Federal Ministry of Education and Research; German Center for Lung Research; Comprehensive Pulmonary Center Munich; Airway Research Center North; Biomedical Research in Endstage and Obstructive Lung Disease Hannover; Translational Lung Research Center Heidelberg; Universities of Giessen and Marburg Lung Center
Recruiting
Gradual Egg-tolerance Induction in Hen's Egg Allergic Children

Condition: Egg Hypersensitivity
Intervention: Behavioral: shorter or longer period of specific dietary restrictions
Sponsors: Dominque Bullens; Jessa Hospital; Algemeen Ziekenhuis Maria Middelares; Imelda Hospital, Bonheiden; AZ Sint-Jan AV
Recruiting
Biomoleculars Markers of Sensitivity to Pre- and Post-operative Chemotherapy of Gastric and Cardia Adenocarcinomas: a Pilot Study

Condition: Gastric and Cardia Adenocarcinomas
Intervention: Procedure: Biopsy
Sponsor: University Hospital, Strasbourg, France
Recruiting
The Research of Standard Diagnosis and Treatment for HSPN in Children

Condition: Henoch-Schoenlein Purpura Nephritis
Interventions: Drug: Prednisone; Drug: Cyclophosphamide(CTX); Drug: Mycophenolate mofetil(MMF); Drug: Leflunomide(LEF); Drug: Angiotensin-converting enzyme inhibitor(ACEI); Drug: Methylprednisolone
Sponsor: Nanjing Children's Hospital
Recruiting
The Research of Standard Diagnosis and Treatment for HSPN With Mild Proteinuria in Children

Condition: Henoch-Schoenlein Purpura Nephritis
Interventions: Drug: Prednisone; Drug: ACEI
Sponsor: Nanjing Children's Hospital
Recruiting
Biomarkers, Blood Pressure, BIS: Risk Stratification/Management of Patients at Cardiac Risk in Major Noncardiac Surgery

Conditions: Hypotension; Postoperative Complications; Acute Coronary Syndrome; Heart Failure; Coronary Occlusion; Stroke; Acute Kidney Injury; Renal Insufficiency, Chronic; Death
Interventions: Drug: Liberal blood pressure management; Drug: Tight blood pressure management
Sponsor: Miodrag Filipovic, Prof. Dr. med.
Recruiting
A Study of Olaparib Prior to Surgery and Chemotherapy in Ovarian, Primary Peritoneal, and Fallopian Tube Cancer

Conditions: Ovarian Cancer; Fallopian Tube Cancer; Neoadjuvant Treatment; Debulking Surgical Procedures
Interventions: Drug: Olaparib; Drug: Platinum-based Chemotherapy
Sponsor: University Health Network, Toronto
Recruiting
Cutaneous and Systemic Reactions to Metal Implants

Condition: Dermatitis, Allergic Contact
Intervention: Other: Patch Test
Sponsors: Winthrop University Hospital; Smart Practice
Recruiting
Registry for Asthma Characterization and Recruitment 2

Condition: Asthma
Intervention:
Sponsors: National Institute of Allergy and Infectious Diseases (NIAID); Inner-City Asthma Consortium
Recruiting
To Assess the Efficacy and Safety of Olaparib Maintenance Monotherapy in the Treatment of Ovarian Cancer

Condition: BRCA or HRR+ Mutated Ovarian Cancer Patients
Intervention: Drug: Olaparib
Sponsor: AstraZeneca
Recruiting
Crizotinib (Xalkori) Expanded Access Protocol For The Treatment Of Adult Or Pediatric Patients

Condition: Neoplasm
Intervention: Drug: Crizotinib
Sponsor: Pfizer
Available
Esophageal Motility in Reflux Induced Cough

Condition: Cough
Intervention: Other: Citric Acid
Sponsors: Mayo Clinic; University of Manchester
Recruiting
Polarization Sensitive Optical Coherence Tomography (PS-OCT) for Retinal Imaging

Condition: Healthy
Intervention: Device: Polarization-Sensitive OFDI
Sponsors: Massachusetts General Hospital; Massachusetts Eye and Ear Infirmary
Not yet recruiting
High-Sensitivity Troponin T Plasma Levels in Patients With Aortic Stenosis (Tyrolean Aortic Stenosis Study-2)

Conditions: Aortic Stenosis; Heart Failure; Syncope; Angina Pectoris
Intervention: Procedure: Aortic Valve Intervention (surgical or transcatheter)
Sponsor: Medical University Innsbruck
Recruiting
Efficacy of Pregabalin on Chronic Cough

Condition: Cough
Interventions: Drug: Pregabalin; Drug: Control-Placebo
Sponsor: Ottawa Hospital Research Institute
Recruiting
Olaparib or Cediranib Maleate and Olaparib Compared With Standard Platinum-Based Chemotherapy in Treating Patients With Recurrent Platinum-Sensitive Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

Conditions: BRCA Rearrangement; Deleterious BRCA1 Gene Mutation; Deleterious BRCA2 Gene Mutation; Fallopian Tube Clear Cell Adenocarcinoma; Fallopian Tube Transitional Cell Carcinoma; Ovarian Clear Cell Adenocarcinoma; Ovarian Endometrioid Tumor; Ovarian Seromucinous Carcinoma; Ovarian Serous Tumor; Ovarian Transitional Cell Carcinoma; Recurrent Fallopian Tube Carcinoma; Recurrent Ovarian Carcinoma; Recurrent Primary Peritoneal Carcinoma; Undifferentiated Fallopian Tube Carcinoma; Undifferentiated Ovarian Carcinoma
Interventions: Drug: Carboplatin; Drug: Cediranib Maleate; Drug: Gemcitabine Hydrochloride; Other: Laboratory Biomarker Analysis; Drug: Olaparib; Drug: Paclitaxel; Drug: Pegylated Liposomal Doxorubicin Hydrochloride; Other: Pharmacological Study; Other: Quality-of-Life Assessment
Sponsors: National Cancer Institute (NCI); AstraZeneca
Recruiting
Efficacy and Safety Study of RAGWITEK™ (MK-3641) in Children With Ragweed-Induced Rhinoconjunctivitis With or Without Asthma (MK-3641-008)

Condition: Rhinitis, Allergic, Seasonal
Interventions: Biological: MK-3641; Biological: Placebo; Drug: Self-injectable epinephrine; Drug: Albuterol/Salbutamol; Drug: Loratadine; Drug: Olopatadine; Drug: Mometasone furoate monohydrate
Sponsor: Merck Sharp & Dohme Corp.
Recruiting
Osteoporosis In Non-Celiac Wheat Sensitivity Patients

Condition: Non-celiac Wheat Sensitivity
Intervention:
Sponsor: University of Palermo
Recruiting
Oral Lesions In Non-Celiac Wheat Sensitivity Patients

Condition: Non-celiac Wheat Sensitivity
Intervention:
Sponsor: University of Palermo
Recruiting
Malnutrition In Non-Celiac Wheat Sensitivity Patients

Condition: Non-Celiac Wheat Sensitivity
Intervention:
Sponsor: University of Palermo
Recruiting
Effect of Fasting on the Asthma Inflammasome

Condition: Asthma
Intervention:
Sponsor: National Heart, Lung, and Blood Institute (NHLBI)
Recruiting
Bronchial Thermoplasty in Severe Asthma With Frequent Exacerbations

Condition: Asthma
Intervention: Device: Bronchial thermoplasty with the Alair System
Sponsor: University Hospital, Strasbourg, France
Recruiting
Trial of AccuPAP Device Versus Standard Nebulizer Therapy in Acute Asthma Exacerbation in Children

Condition: Asthma
Interventions: Device: AccuPAP; Drug: Albuterol and Ipratropium Continuous Nebulizer
Sponsor: Vanderbilt University Medical Center
Recruiting
Effect of Levothyroxine on Serum Adiponectin, Insulin Resistance and Cardiovascular Risk in Patients With Hypothyroidism

Condition: Hypothyroidism
Intervention: Drug: Levothyroxine
Sponsor: All India Institute of Medical Sciences, Bhubaneswar
Recruiting
Two Doses of the Intravenous Magnesium Sulfate Versus the Standard Single Dose ,With/ Without the Nebulized Budesonide For the Management of the Severe Asthma Exacerbation in the Emergency Room; A Randomized Controlled Trial.

Condition: Bronchial Asthma
Interventions: Drug: Intravenous magnesium sulfate; Drug: Inhaled budesonide; Drug: normal saline
Sponsor: Hamad Medical Corporation
Recruiting
Fibrostenotic Eosinophilic Esophagitis: Assessment Tools

Condition: Eosinophilic Esophagitis
Intervention:
Sponsor: University of Colorado, Denver
Recruiting
A Randomized Trial of Itraconazole in Acute Stages of Allergic Bronchopulmonary Aspergillosis

Condition: Allergic Bronchopulmonary Aspergillosis
Interventions: Drug: Itraconazole; Drug: Glucocorticoids
Sponsor: Postgraduate Institute of Medical Education and Research
Recruiting
Use of Text Messages to Improve Care For Children Following an ED Visit for Asthma

Condition: Asthma
Interventions: Behavioral: Targeted text messages; Behavioral: General text messages
Sponsors: Children's Hospitals and Clinics of Minnesota; HealthPartners Institute
Recruiting
Screening Protein Markers in Patients With Rheumatoid Arthritis and Hot-dampness and Blood Stasis Syndrome

Condition: Arthritis, Rheumatoid
Intervention:
Sponsors: Guang'anmen Hospital of China Academy of Chinese Medical Sciences; National Natural Science Foundation of China
Recruiting
Food Antigen in Eosinophilic Esophagitis

Condition: Eosinophilic Esophagitis
Intervention: Other: Antigen (wheat base soy sauce) spray
Sponsor: Mayo Clinic
Recruiting
Effectiveness of Prazosin on the Urinary Sodium Excretion Response to Mental Stress

Conditions: Hypertension; Stress, Psychological; Blood Pressure
Interventions: Drug: Prazosin; Drug: Placebo
Sponsors: Augusta University; The University of Texas at Arlington
Recruiting
Multicenter Validation of the Sensitivity of Theranostic ALK Rearrangement Detection by FISH Analysis and Prevalence of Escaping Mutations in Circulating Tumor Cells for the Non-invasive Management of Lung Cancer Patients

Condition: Lung Neoplasms
Intervention: Other: ALK analysis on CTCs detected by ISET
Sponsor: Centre Hospitalier Universitaire de Nice
Recruiting
Effectiveness of Avapro in Obese Normotensive/Hypertensive African Americans

Conditions: Hypertension; Obesity; Stress, Psychological; Blood Pressure
Interventions: Drug: Irbesartan; Other: Placebo
Sponsor: Augusta University
Recruiting
Gut Permeability, Sensitivity and Symptomatology

Conditions: Irritable Bowel Syndrome; Visceral Hypersensitivity
Interventions: Procedure: Gastrointestinal Permeability Test; Procedure: Upper Endoscopy; Procedure: Rectal Barostat and Infusion of Fats
Sponsors: Mayo Clinic; University of Erlangen-Nürnberg; Heidelberg University
Recruiting
Understanding the Relationship Between Inflammation and Insulin Resistance in the Adipose Tissue

Conditions: Obesity; Insulin Resistance
Interventions: Procedure: Fat biopsy during scheduled abdominal surgery; Procedure: Fat Aspiration; Dietary Supplement: Fish Oil Supplement
Sponsor: Mayo Clinic
Recruiting
Airway Temperature

Condition: Asthma
Intervention: Biological: Segmental Bronchoprovocation with Allergen (SBP-Ag)
Sponsors: Lu Yuan Lee; National Institute of Allergy and Infectious Diseases (NIAID)
Not yet recruiting
Vitamin K and Glucose Metabolism in Adults at Risk for Diabetes (Vita-K 'n' Adults Study)

Conditions: Obesity; Insulin Resistance; Insulin Sensitivity; Beta-Cell Dysfunction; Prediabetes
Interventions: Dietary Supplement: Placebo; Dietary Supplement: Low-Dose Vitamin K2 Supplement (menaquinone-7; 90-mcg/d); Dietary Supplement: High-Dose Vitamin K2 Supplement (menaquinone-7; 180-mcg/d)
Sponsors: Augusta University; University of Alabama at Birmingham; Yale University; Tufts University; Nattopharma ASA
Recruiting
Evaluation of Potential Allergenicity of New Wheat Varieties

Conditions: Food Allergy; Wheat Allergy
Intervention:
Sponsors: University of Colorado, Denver; Monsanto Company, LLC
Recruiting
Evaluate the Mediators of Sensitivity and Resistance to Nivolumab Plus Ipilimumab in Patients With Advanced NSCLCs

Condition: Advanced Stage Non-small Cell Lung Cancer
Interventions: Drug: nivolumab; Drug: pilimumab
Sponsors: Memorial Sloan Kettering Cancer Center; Bristol-Myers Squibb
Recruiting
The Effect of Artificial Sweeteners (AFS) on Sweetness Sensitivity, Preference and Brain Response in Adults

Conditions: Impairment of Oral Perception; Insulin Resistance
Interventions: Dietary Supplement: Sucralose; Dietary Supplement: Sucrose; Dietary Supplement: Sucralose + maltodextrin; Dietary Supplement: Sucralose + Sucrose
Sponsor: Yale University
Recruiting
EndoFLIP Use in Upper GI Tract Stenosis

Conditions: Esophageal Stricture; Eosinophilic Esophagitis; Zenkers Diverticulum; Schatzki Ring
Intervention: Device: EndoFLIP
Sponsor: University of Pennsylvania
Recruiting
A Randomized Prospective Clinical Trial of Fel d 1 Peptide Immunotherapy

Conditions: Cat Allergy; Cat Hypersensitivity
Interventions: Drug: Cat-PAD; Drug: Placebo
Sponsors: National Institute of Allergy and Infectious Diseases (NIAID); Circassia Limited
Recruiting
SCar-biopsies After Malignant Colorectal Polypectomy of Uncertain RAdicality

Condition: Colorectal Cancer
Intervention: Procedure: Flexible sigmoidoscopy or colonoscopy
Sponsors: Dr. Frank ter Borg MD PhD; Erasmus Medical Center; The Netherlands Cancer Institute; Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA); UMC Utrecht
Recruiting
Bakery Products for Non-Coeliac Gluten Sensitive Consumers

Condition: Non Coeliac Gluten Sensitivity
Interventions: Other: Normal gluten containing bread; Other: Bread with reduced gliadins content; Other: Bread with reduced ATIs content; Other: Bread with reduced overall protein content
Sponsor: University of Aberdeen
Recruiting
Structure and Function MRI of Asthma

Condition: Asthma
Intervention: Other: Hyperpolarized Noble Gas MRI
Sponsor: Dr. Grace Parraga
Recruiting
Safety and Efficacy Study of Enzalutamide Plus Leuprolide in Patients With Nonmetastatic Prostate Cancer (EMBARK)

Conditions: Hormone Sensitive Prostate Cancer; Prostate Cancer; Cancer of the Prostate
Interventions: Drug: Enzalutamide; Drug: Placebo; Drug: Leuprolide
Sponsors: Pfizer; Astellas Pharma Inc; Medivation, Inc.
Recruiting
Determinism of the Mechanism of Action of Specific Immunotherapy in Hymenoptera Venom Allergy

Condition: Hymenoptera Allergy
Interventions: Procedure: biological sampling; Biological: Desensitization protocol (Alyostall®)
Sponsor: University Hospital, Rouen
Recruiting
Effectivness and Safety of Acupuncture Combined With Moxibustion for Allergic Rhinitis

Condition: Rhinitis, Allergic, Perennial
Interventions: Other: acupuncture combined moxibustion; Drug: Loratadine
Sponsors: Zhao Hong; China Academy of Chinese Medical Sciences; Beijing Municipal Science & Technology Commission
Recruiting
A Study to Assess the Efficacy and Safety of Farletuzumab (MORAb 003) in Combination With Carboplatin Plus Paclitaxel or Carboplatin Plus Pegylated Liposomal Doxorubicin (PLD) in Subjects With Low CA125 Platinum-Sensitive Ovarian Cancer

Condition: Platinum-Sensitive Ovarian Cancer in First Relapse
Interventions: Drug: Farletuzumab; Drug: Placebo
Sponsors: Morphotek; Eisai Co., Ltd.
Recruiting
NHALES (Natural History of Asthma With Longitudinal Environmental Sampling)

Condition: Asthma
Intervention:
Sponsor: National Institute of Environmental Health Sciences (NIEHS)
Recruiting
Probiotic Supplementation in Breastfed Newborn Infants

Conditions: Atopic Dermatitis; Food Allergies
Interventions: Drug: B. infantis; Drug: Placebo
Sponsor: Emanual Maverakis, MD
Recruiting
Olaparib Treatment in Relapsed Germline Breast Cancer Susceptibility Gene (BRCA) Mutated Ovarian Cancer Patients Who Have Progressed at Least 6 Months After Last Platinum Treatment and Have Received at Least 2 Prior Platinum Treatments

Condition: Relapsed Ovarian Cancer, BRCA Mutation, Platinum Sensitivity
Interventions: Drug: OLAPARIB; Drug: Single agent chemotherapy
Sponsors: AstraZeneca; Myriad Genetic Laboratories, Inc.
Recruiting
RCT of Itraconazole for Fungal Sensitive Chronic Rhinosinusitis With Nasal Polyps

Condition: Chronic Rhinosinusitis
Interventions: Drug: Itraconazole; Drug: Placebo
Sponsor: The University of Texas Health Science Center, Houston
Recruiting
Topical Clobetasol for the Treatment of Toxic Epidermal Necrolysis

Condition: Toxic Epidermal Necrolysis
Interventions: Drug: Clobetasol 0.05% ointment; Drug: Placebo
Sponsor: University of California, Davis
Recruiting
Enzalutamide Versus Standard Androgen Deprivation Therapy for the Treatment Hormone Sensitive Prostate Cancer

Conditions: Adenocarcinoma of the Prostate; Recurrent Prostate Cancer; Stage III Prostate Cancer; Stage IV Prostate Cancer
Interventions: Drug: Enzalutamide; Drug: leuprolide acetate; Drug: goserelin acetate; Drug: histrelin acetate; Drug: triptorelin; Drug: degarelix
Sponsor: University of Colorado, Denver
Recruiting
Study of the Role of Regulator T Cells in the Pathophysiology of Childhood Henoch Schönlein Purpura

Condition: Henoch Schönlein Purpura
Interventions: Biological: Blood samples; Biological: Stool samples
Sponsor: Centre Hospitalier Universitaire de Nīmes
Recruiting
Role of Omalizumab in Reducing the Incidence of Oxaliplatin-induced Hypersensitivity Reaction

Condition: Colon Cancer
Intervention: Drug: Omalizumab
Sponsor: Yale University
Recruiting
Corneal Sensitivity in Patients With Sleep Apnea Syndrome

Condition: Sleep Apnea
Intervention:
Sponsor: University of Texas Southwestern Medical Center
Recruiting
Applying Interactive Mobile Health to Asthma Care in Teens (AIM2ACT)

Condition: Asthma
Interventions: Behavioral: AIM2ACT; Behavioral: Self-guided
Sponsors: University of Florida; The Miriam Hospital; Rhode Island Hospital; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting
School Inner-City Asthma Intervention Study (SICAS-2)

Condition: Asthma
Interventions: Other: integrated pest management; Other: air purifier; Other: No intervention (control)
Sponsors: Boston Children’s Hospital; National Institutes of Health (NIH); National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting
Assessing PA-824 for Tuberculosis (the APT Trial)

Condition: Pulmonary Tuberculosis
Interventions: Drug: PA-824; Drug: Rifampin; Drug: Rifabutin; Drug: Pyrazinamide; Drug: Ethambutol; Drug: Isoniazid
Sponsor: Johns Hopkins University
Recruiting
Asthma Symptom Management Through Mindfulness Training

Condition: Asthma
Interventions: Behavioral: Mindfulness Based Stress Reduction (MBSR); Behavioral: Healthy Living Course (HLC)
Sponsors: University of Massachusetts, Worcester; The Miriam Hospital
Recruiting
Inflammatory Cells From Various Pathologies

Conditions: Atopic Dermatitis; Acne Rosacea; Acne Vulgaris
Intervention:
Sponsor: Innovaderm Research Inc.
Recruiting
Critical Periods After Stroke Study (CPASS)

Conditions: Stroke; Brain Infarction; Brain Ischemia; Cerebral Infarction; Cerebrovascular Disorders
Interventions: Behavioral: Early Intensive upper extremity motor training; Behavioral: Sub-acute intensive upper extremity motor training; Behavioral: Chronic intensive upper extremity motor training; Behavioral: Control
Sponsors: MedStar National Rehabilitation Network; Georgetown University; University of Wisconsin, Madison; The Catholic University of America; Medstar Health Research Institute
Recruiting
Indoor Air Pollution and Children With Asthma: An Intervention Trial

Condition: Asthma
Interventions: Other: NO2 Scrubber; Other: HEPA filter; Other: Control
Sponsors: Yale University; Harvard University; National Institute of Environmental Health Sciences (NIEHS)
Recruiting
Environmental Control as Add-on Therapy in Childhood Asthma

Condition: Asthma
Interventions: Drug: Flovent Diskus; Other: Home Environmental Intervention; Drug: Advair Diskus
Sponsor: Johns Hopkins University
Recruiting
Diagnostic Significance of Positive EmA Antibodies in the Duodenal Culture Medium of Not-Celiac Wheat Sensitivity (NCWS)

Condition: Not-celiac Gluten Sensitivity
Intervention:
Sponsor: University of Palermo
Recruiting
Spirometric Response to Bronchial Thermoplasty in Patients With Severe Asthma

Condition: Asthma
Intervention: Procedure: Bronchial Thermoplasty
Sponsor: University of Oklahoma
Recruiting
Blood Samples for the Study of Peanut, Tree Nut and Other Food Allergies

Conditions: Peanut Allergies; Tree Nut Allergies; Other Food Allergies
Intervention:
Sponsors: University of Colorado, Denver; National Institutes of Health (NIH)
Recruiting
Reduction of Peanut Reactivity and Immune Modulation With Anti-IgE Therapy

Condition: Peanut Allergy
Intervention:
Sponsors: Weill Medical College of Cornell University; Yale University
Recruiting
Endogenous Opioid Mechanisms for Rejection Sensitivity

Condition: Rejection Sensitivity
Intervention:
Sponsors: Stony Brook University; University of Michigan; National Institute of Mental Health (NIMH)
Recruiting
Study of the Inflammation and Airway Changes That Occur After Exposure to Allergen in Asthmatics

Condition: Asthma
Intervention: Biological: Segmental airway allergen challenge
Sponsors: University of California, San Francisco; National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting
A Pilot Study of Zavesca® in Patients With Pompe Disease and Infusion Associated Reaction

Conditions: Pompe Disease; Hypersensitivity Reaction
Intervention: Drug: Zavesca® Prescription
Sponsors: University of Florida; Amicus Therapeutics
Recruiting
Using Spectrally Encoded Confocal Microscopy (SECM) to Image the Esophagus

Condition: Eosinophilic Esophagitis
Intervention: Device: SECM Capsule
Sponsors: Massachusetts General Hospital; National Institutes of Health (NIH); National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting
Comparison of the Sensitivity and Specificity of Acoustic Angiography to the Sensitivity and Specificity of Conventional Ultrasound

Condition: Signs and Symptoms
Intervention: Device: Acoustic Angiography
Sponsors: UNC Lineberger Comprehensive Cancer Center; National Cancer Institute (NCI)
Recruiting
School-based Asthma Care for Teens (SB-ACT)

Condition: Asthma
Interventions: Behavioral: School-Based Asthma Care for Teens (SB-ACT); Behavioral: Directly Observed Therapy; Behavioral: Asthma Education
Sponsors: University of Rochester; National Heart, Lung, and Blood Institute (NHLBI)
Recruiting
Study to Image the Esophagus Using the OFDI Capsule

Conditions: Barrett's Esophagus; Eosinophilic Esophagitis
Intervention: Device: OFDI Capsule
Sponsors: Massachusetts General Hospital; National Institutes of Health (NIH); National Cancer Institute (NCI)
Recruiting
Paleo Versus Healthy ADA Diets for Treatment of Polycystic Ovarian Syndrome (PCOS)

Condition: Polycystic Ovarian Syndrome
Interventions: Other: Paleolithic diet; Other: American Diabetes Association diet
Sponsor: University of California, San Francisco
Recruiting
Caries Prevention Products & Dentinal Hypersensitivity

Condition: Hypersensitivity
Interventions: Device: Sensodyne; Device: Crest Cavity Protection & MI Paste Plus; Device: Clinpro 5000
Sponsor: Tufts University School of Dental Medicine
Recruiting
EmPhAsIS: Empowering Pharmacists in Asthma Management Through Interactive SMS

Condition: Asthma
Interventions: Other: Interactive SMS; Other: Usual care
Sponsors: University of British Columbia; WelTel; College of Pharmacists of British Columbia; Canadian Institutes of Health Research (CIHR)
Recruiting
Blinatumomab and Combination Chemotherapy or Dasatinib, Prednisone, and Blinatumomab in Treating Older Patients With Acute Lymphoblastic Leukemia

Conditions: Acute Lymphoblastic Leukemia; B Acute Lymphoblastic Leukemia; B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1; B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative; Philadelphia Chromosome Positive; Recurrent Adult Acute Lymphoblastic Leukemia; Refractory Adult Acute Lymphoblastic Leukemia; Untreated Adult Acute Lymphoblastic Leukemia
Interventions: Biological: Blinatumomab; Drug: Dasatinib; Other: Laboratory Biomarker Analysis; Drug: Mercaptopurine; Drug: Methotrexate; Drug: Prednisone; Drug: Vincristine Sulfate
Sponsor: National Cancer Institute (NCI)
Recruiting
Mechanism of Microbiome-induced Insulin Resistance in Humans (Aim2)

Condition: Insulin Sensitivity
Interventions: Drug: Maltodextrin; Drug: Synbiotic; Drug: Sevelamer
Sponsors: The University of Texas Health Science Center at San Antonio; American Diabetes Association
Recruiting
Can Vitamin D Supplementation in Infants Prevent Food Allergy in the First Year of Life? The VITALITY Trial

Condition: Food Allergy
Interventions: Drug: Vitamin D; Drug: placebo
Sponsor: Murdoch Childrens Research Institute
Recruiting
Mechanism of Microbiome-induced Insulin Resistance in Humans (Aim 1)

Condition: Insulin Sensitivity
Interventions: Drug: Sevelamer; Drug: Synbiotic; Drug: Maltodextrin
Sponsors: The University of Texas Health Science Center at San Antonio; American Diabetes Association
Recruiting
Nasal Mucus Proteome and Immunotherapy

Condition: Allergic Rhinoconjunctivitis
Intervention: Biological: Immunotherapy
Sponsor: Medical University of Graz
Recruiting
p53 Suppressor Activation in Recurrent High Grade Serous Ovarian Cancer, a Phase Ib/II Study of Systemic Carboplatin Combination Chemotherapy With or Without APR-246

Condition: Platinum Sensitive Recurrent High-grade Serous Ovarian Cancer With Mutated p53
Interventions: Drug: APR-246; Drug: Carboplatin and Pegylated Liposomal Doxorubicin Hydrochloride (PLD)
Sponsor: Aprea Therapeutics AB
Recruiting
Long-Term Safety Evaluation of Dupilumab in Patients With Asthma (LIBERTY ASTHMA TRAVERSE)

Condition: Asthma
Intervention: Drug: dupilumab SAR231893 (REGN668)
Sponsors: Sanofi; Regeneron Pharmaceuticals
Recruiting
Low-dose Methotrexate for Change in Global Initiative for Asthma Step 5 Medications in Chronic Severe Asthma

Condition: Low Dose Methotrexate in Severe Chronic Asthma
Interventions: Drug: Methotrexate; Drug: Placebo
Sponsor: Universita degli Studi di Catania
Not yet recruiting
Characterizing Asthma Sputum Elasticity in the UCSF Severe Asthma Research Program

Condition: Asthma
Intervention:
Sponsor: University of California, San Francisco
Recruiting
Effect of Skipping Breakfast on Metabolic Function

Conditions: Skipping Breakfast; Circadian Rhythms
Interventions: Other: 3 standard meals/day; Other: 2 meals/day (omit breakfast)
Sponsor: Washington University School of Medicine
Recruiting
Value of Sonographic Diagnosis of Toddler's Fracture of the Tibia

Condition: Pediatric Fractures
Intervention:
Sponsor: Universitätsklinikum Hamburg-Eppendorf
Recruiting
Effect of High-intensity Low-volume Training on Insulin Sensitivity in Type 2 Diabetes

Condition: Type 2 Diabetes
Intervention: Other: High intensity interval training
Sponsor: German Diabetes Center
Recruiting
Noninvasive Staging of Liver Fibrosis: MR vs Ultrasound

Conditions: Hepatitis C; Hepatitis B; Nonalcoholic Fatty Liver Disease (NAFLD); Nonalcoholic Steatohepatitis (NASH)
Intervention: Device: Transient elastography, acoustic radiation force impulse, magnetic resonance elastography
Sponsors: Centre hospitalier de l'Université de Montréal (CHUM); Canadian Institutes of Health Research (CIHR); Centre de Recherche du Centre Hospitalier de l'Université de Montréal
Recruiting
Cross Correlation of Pain Hypersensitivity and Clinical Features and Electromyography in Low Back Pain Patients

Condition: Low Back Pain
Intervention:
Sponsor: University of Belgrade
Recruiting
Uncontrolled Lower Respiratory Symptoms in the WTC Survivor Program

Conditions: Lung Diseases; Medication Compliance
Interventions: Drug: Fluticasone propionate 230mcg for 3 Months; Drug: Current Treatment or no treatment; Drug: Salmeterol 21mcg for 3 Months
Sponsors: New York University School of Medicine; National Institute for Occupational Safety and Health (NIOSH/CDC)
Recruiting
Effect of Exercise on Metabolic Health

Condition: Obesity
Intervention: Other: Exercise
Sponsors: University of Michigan; American Diabetes Association
Recruiting
Esophageal String Test in Eosinophilic Esophagitis

Condition: Eosinophilic Esophagitis
Intervention:
Sponsors: University of Colorado, Denver; University of Illinois at Chicago; Northwestern University; OSF St. Francis Medical Center
Recruiting
Azithromycin for Children Hospitalized With Asthma

Condition: Asthma
Interventions: Drug: Azithromycin; Drug: Placebo
Sponsor: Montefiore Medical Center
Recruiting
Vitamin K and Glucose Metabolism in Children at Risk for Diabetes (Vita-K 'n' Kids Study)

Conditions: Obesity; Insulin Resistance; Insulin Sensitivity; Prediabetes; Dyslipidemia; Diabetes
Interventions: Dietary Supplement: Placebo-Control; Dietary Supplement: Low-Dose Vitamin K2 (menaquinone-7; 45 mcg/d); Dietary Supplement: High-Dose Vitamin K2 (menaquinone-7; 90 mcg/d)
Sponsors: Augusta University; University of Alabama at Birmingham; Yale University; Tufts University; Nattopharma ASA
Recruiting
Cesarean Section Study

Conditions: Diarrhea; Atopic Dermatitis
Intervention: Dietary Supplement: Probiotic
Sponsor: Nestlé
Recruiting
Evaluation of Potential Allergenicity of New Soybean Varieties

Condition: Soy Allergy
Intervention: Other: Oral food challenge
Sponsor: University of Colorado, Denver
Recruiting
Study of Carfilzomib With Irinotecan in Irinotecan-Sensitive Malignancies and Small Cell Lung Cancer Patients

Conditions: Small Cell Lung Carcinoma; Non Small Cell Lung Carcinoma; Irinotecan Sensitive Cancers
Interventions: Drug: Carfilzomib; Drug: Irinotecan
Sponsors: Cancer Research and Biostatistics Clinical Trials Consortium; Lucille P. Markey Cancer Center at University of Kentucky; Washington University School of Medicine
Recruiting
Thin Film Spectacle Coatings to Reduce Light Sensitivity and Headaches in Child and Adolescent Patients With Migraine

Conditions: Migraine Disorders; Photophobia
Intervention: Device: Investigational Coating
Sponsors: University of Utah; Primary Children's Hospital
Recruiting
TransMEM Gas Exchange -- Project 1, Aim 2

Conditions: Middle Ear Disease; Nasal Allergy
Interventions: Biological: ragweed; Biological: histamine; Drug: pseudoephedrine; Drug: Oxymetazoline
Sponsors: Cuneyt M. Alper; National Institute on Deafness and Other Communication Disorders (NIDCD)
Recruiting
High-Dose Isoniazid Among Adult Patients With Different Genetic Variants of INH-Resistant Tuberculosis (TB)

Condition: Tuberculosis
Interventions: Drug: Isoniazid; Dietary Supplement: Vitamin B6
Sponsors: AIDS Clinical Trials Group; National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting
Mucosal Impedance and Eosinophilic Esophagitis

Condition: Eosinophilic Esophagitis
Intervention: Device: Mucosal Impedance
Sponsor: Mayo Clinic
Recruiting
Mechanistic Study of Duloxetine Versus Placebo in Breast Cancer Patients With Chronic Pain

Condition: Pain
Intervention: Drug: Duloxetine
Sponsors: University of Utah; American Cancer Society, Inc.
Recruiting
Antibody Treatment for Advanced Celiac Disease

Conditions: Celiac Disease; Celiac Sprue; Gluten Enteropathy; Gluten-Sensitive Enteropathy
Intervention: Biological: Hu-Mik- Beta-1
Sponsors: National Cancer Institute (NCI); Mayo Clinic
Recruiting
Eicosanoid Lipids by Airway Cells During Infection With Human Rhinoviruses

Condition: Asthma
Intervention:
Sponsors: University of Wisconsin, Madison; National Institutes of Health (NIH); National Heart, Lung, and Blood Institute (NHLBI)
Recruiting
Molecular Basis of Food Allergy

Conditions: Food Allergy; Eosinophilic Esophagitis
Intervention:
Sponsors: Children's Hospital of Philadelphia; University of Pennsylvania; National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting
Bio-markers of Not-celiac Wheat Sensitivity

Condition: Not-celiac Wheat Sensitivity
Interventions: Dietary Supplement: wheat flour; Dietary Supplement: Xylose
Sponsor: University of Palermo
Recruiting
Outcomes After Secondary Cytoreductive Surgery With or Without Carboplatin Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Followed by Systemic Combination Chemotherapy for Recurrent Platinum-Sensitive Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

Conditions: Ovarian Cancer; Fallopian Tubes Cancer; Peritoneal Cancer
Interventions: Procedure: Secondary Cytoreductive Surgery; Drug: Carboplatin Hyperthermic Intraperitoneal Chemotherapy (HIPEC); Drug: platinum-based systemic chemotherapy postoperatively
Sponsors: Memorial Sloan Kettering Cancer Center; Mayo Clinic; Baptist Health South Florida; Hartford HealthCare; University of Pittsburgh; University of Chicago
Recruiting
Comparative Study of Pathophysiological Mechanisms and Bronchial Response in Occupational Asthma to Wheat Flour and Quaternary Ammonium Compounds During Standardized Bronchial Provocation Tests

Condition: Occupational Asthma
Intervention: Other: standardized bronchial challenge test (SCL SCL • • GenaSOL ™ GenaSIC ™)
Sponsor: University Hospital, Strasbourg, France
Recruiting
Defining the Skin and Blood Biomarkers of Pediatric Atopic Dermatitis

Conditions: Atopic Dermatitis; Eczema
Intervention:
Sponsors: Northwestern University; Rockefeller University
Recruiting
Longitudinal Observational Study of Severe Asthma

Condition: Asthma
Intervention:
Sponsor: National Heart, Lung, and Blood Institute (NHLBI)
Recruiting
Testing the Effectiveness of Henna on Managing PPE

Condition: Palmar-plantar Erythrodysesthesia (PPE)
Interventions: Drug: Henna; Drug: Placebo
Sponsor: Cyprus University of Technology
Recruiting
Alglucosidase Alfa Pompe Safety Sub-Registry

Condition: Pompe Disease
Intervention: Biological: alglucosidase alfa
Sponsor: Genzyme, a Sanofi Company
Recruiting
Growth and Plasma Amino Acids in Infants With CMPA and Treated With a Newly Innovated Amino Acid Formula

Condition: Cow Milk Allergy
Intervention: Dietary Supplement: Comparison of treatment with different amino acid formulas
Sponsor: Mahidol University
Recruiting
Diagnostic Performance of 18F-FDG-PET and Diffusion-weighted MRI in the Assessment of Stage IB to IIB2 Cervical Squamous-cell Carcinoma Response to Concomitant Radiochemotherapy and Brachytherapy

Condition: Cancer of the Uterine Cervix
Intervention: Device: 18F-FDG-PET
Sponsor: Hospices Civils de Lyon
Recruiting
Understanding and Diagnosing Allergic Disease in Twins

Condition: Allergies
Intervention: Other: No Intervention
Sponsor: Stanford University
Recruiting
Surgery or Chemotherapy in Recurrent Ovarian Cancer (SOC 1 Trial)?

Conditions: Ovarian Epithelial Cancer Recurrent; Fallopian Tube Carcinoma; Primary Peritoneal Carcinoma
Interventions: Procedure: Secondary Cytoreductive Surgery; Drug: Salvage Chemotherapy
Sponsors: Shanghai Gynecologic Oncology Group; Fudan University; Zhejiang Cancer Hospital; Shanghai Zhongshan Hospital; Sun Yat-sen University
Recruiting
Effects of Treatments on Atopic Dermatitis

Condition: Dermatitis, Atopic
Interventions: Drug: Trimethoprim/sulfamethoxazole (TMP/SMZ); Drug: Cephalexin; Drug: Doxycycline; Other: Sodium hypochlorite
Sponsor: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Recruiting
Evaluating the Effects of a Study Medication on Exercise Function in Type 2 Diabetes

Condition: Type 2 Diabetes
Interventions: Drug: Acipimox; Drug: Placebo
Sponsors: University of Colorado, Denver; VA Office of Research and Development; Pfizer
Recruiting
Cytosponge Protocol IRB 11-006429

Condition: Eosinophilic Esophagitis
Intervention: Device: Cytosponge - Brushing
Sponsors: Mayo Clinic; University of Cambridge
Recruiting
An Observational Study to Evaluate The Relationship of Nasal Mucus Properties and Symptoms

Conditions: Acute Rhinosinusitis; Allergic Rhinitis
Intervention:
Sponsor: Virginia Commonwealth University
Recruiting
The Effect of Bariatric Surgery on Insulin Sensitivity and Energy Metabolism

Conditions: Obesity; Diabetes Mellitus, Non-Insulin-Dependent
Intervention: Procedure: surgery
Sponsors: German Diabetes Center; Dep.of General-, Visceral- and Pediatric Surgery, HHU, Duesseldorf; Dep.for Metabolic Diseases, HHU, Duesseldorf
Recruiting
Role of microRNAs in T Cell-Driven Inflammation in Asthma

Condition: Asthma
Intervention: Drug: Budesonide
Sponsors: University of California, San Francisco; National Heart, Lung, and Blood Institute (NHLBI)
Recruiting
Relationship Between Systemic Fatty Acid Availability and Insulin Sensitivity

Condition: Obesity
Intervention:
Sponsors: University of Michigan; National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting
Magnesium Nebulization Utilization in Management of Pediatric Asthma

Condition: Acute Asthma
Interventions: Drug: Magnesium Sulfate Sandoz; Drug: Sodium Chloride , USP PPC
Sponsors: The Hospital for Sick Children; Canadian Institutes of Health Research (CIHR); Alberta Children's Hospital; St. Justine's Hospital; Children's Hospital of Eastern Ontario; Stollery Children's Hospital; The Children's Hospital of Winnipeg; Provincial Health Services Authority
Recruiting
Difference in GC-induced Adrenal Insufficiency in RA Related to Polymorphisms in the Glucocorticoid Receptor Gene

Condition: Rheumatoid Arthritis
Intervention: Diagnostic Test: Synacthen test
Sponsor: Rigshospitalet, Denmark
Recruiting
The Effect of Long-Acting Mesalamine on Post-Infective Irritable Bowel Syndrome- A Pilot Study

Condition: Irritable Bowel Syndrome
Interventions: Drug: Mesalamine; Drug: Placebo
Sponsors: University of Utah; Shire Human Genetic Therapies, Inc.
Recruiting
C1 Inhibitor Registry in the Treatment of Hereditary Angioedema (HAE) Attacks

Condition: Hereditary Angioedema
Intervention: Drug: rhC1INH or pdC1INH
Sponsor: Pharming Technologies B.V.
Recruiting
Motivational Intervention for Asthma

Condition: Asthma
Interventions: Behavioral: Motivational Communication; Behavioral: Control
Sponsors: Hopital du Sacre-Coeur de Montreal; Jewish General Hospital
Recruiting
Genomic Testing for Primary Breast Cancer

Condition: Breast Cancer
Interventions: Procedure: Tumor Biopsy; Other: Breast Cancer Registry
Sponsor: M.D. Anderson Cancer Center
Recruiting
Mechanism(s) of Airflow Limitation During Exacerbation of Asthma

Condition: Asthma
Intervention: Drug: budesonide/formoterol or fluticasone/salmeterol in all asthmatics
Sponsor: Gelb, Arthur F., M.D.
Recruiting
A Prospective Observational Study of Biopredictors of Bronchial Thermoplasty Response in Patients With Severe Refractory Asthma (BTR Study)

Condition: Asthma
Intervention: Device: Alair system
Sponsors: Washington University School of Medicine; The Cleveland Clinic; National Jewish Health; University of Arizona; University of Chicago; Louisiana State University Health Sciences Center in New Orleans; University of Alabama at Birmingham; Creighton University
Recruiting
Natural History of Diseases Associated With Allergic Inflammation: Atopic Dermatitis and Genetic and Congenital Diseases Associated With Atopic Pathways

Condition: Atopic Dermatitis
Intervention:
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting
Collecting and Studying Blood and Tissue Samples From Patients With Locally Recurrent or Metastatic Prostate or Bladder/Urothelial Cancer

Conditions: Healthy Control; Localized Urothelial Carcinoma of the Renal Pelvis and Ureter; Metastatic Malignant Neoplasm in the Bone; Metastatic Malignant Neoplasm in the Soft Tissues; Metastatic Urothelial Carcinoma of the Renal Pelvis and Ureter; Recurrent Bladder Carcinoma; Recurrent Prostate Carcinoma; Recurrent Urothelial Carcinoma of the Renal Pelvis and Ureter; Stage IV Bladder Cancer; Stage IV Bladder Urothelial Carcinoma; Stage IV Prostate Cancer
Interventions: Other: Cytology Specimen Collection Procedure; Other: Laboratory Biomarker Analysis
Sponsors: University of Washington; National Cancer Institute (NCI)
Recruiting
Trial of Aerobic Exercise Training in Stroke Survivors

Conditions: Stroke; Insulin Resistance; Sedentary Lifestyle
Interventions: Behavioral: Aerobic Exercise; Behavioral: Stretching
Sponsors: Baltimore VA Medical Center; National Institute on Aging (NIA)
Recruiting
A Randomized, Double-Blind, Placebo-Controlled Study of Omalizumab for Idiopathic Anaphylaxis

Conditions: Anaphylaxis; Hypotension; Bronchospasm; Angioedema
Interventions: Drug: Epinephrine; Procedure: Bone Marrow Apsiration; Drug: Omalizumab (Xolair)
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting
Pathogenesis of Physical Induced Urticarial Syndromes

Conditions: Autoinflammatory Syndromes; Physical Urticaria
Intervention:
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting
Screening Protocol for Genetic Diseases of Allergic Inflammation

Conditions: Piebaldism; Idiopathic Anaphylaxis; Allergy; Chronic Urticara; Angioedema
Intervention:
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting
Effect of Exendin-(9-39) On Glucose Requirements To Maintain Euglycemia

Condition: Congenital Hyperinsulinism
Interventions: Drug: exendin-(9-39); Other: placebo
Sponsor: Diva De Leon
Recruiting
Normal Blood, Bone Marrow and Buccal Mucosa Protocol

Condition: Normal Volunteer Controls
Intervention:
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting
Cause of Unexplained Anaphylaxis

Condition: Anaphylaxis
Intervention:
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting
Potential Research Study Participant Registry

Conditions: Acne; Actinic Keratosis; Dysplastic Nevi; Eczema; Psoriasis; Skin Cancer; Rosacea; Leg Ulcers; Foot Ulcers; Atopic Dermatitis
Intervention:
Sponsor: University of California, Davis
Recruiting
Studies of Skin Microbes in Healthy People and in People With Skin Conditions

Conditions: Atopic Dermatitis; Eczema; Ichthyosis Vulgaris
Intervention:
Sponsor: National Human Genome Research Institute (NHGRI)
Recruiting
Pilot Study to Identify the Mediators and Inflammatory Cell Surface Receptors Involved in Allergic Airway Inflammation

Condition: Asthma
Intervention: Biological: Bronchoscopy, Segmental Allergen Challenge, and Broncheoalveolar Lavage
Sponsors: Andrew D. Luster, M.D.,Ph.D.; National Institutes of Health (NIH); U.S. Army Medical Research and Materiel Command
Recruiting
Mechanism(s)of Airflow Limitation in Moderate-severe Persistent Asthma

Condition: Asthma
Interventions: Drug: budesonide/formoterol; Drug: fluticasone/salmeterol; Drug: mometasone/formoterol; Drug: Prednisone
Sponsor: Gelb, Arthur F., M.D.
Recruiting
10 Year Registry of Children (Ages 2-17 Years) With Eczema That Have Used Pimecrolimus

Condition: Atopic Dermatitis
Intervention: Drug: Pimecrolimus
Sponsors: Valeant Pharmaceuticals International, Inc.; Clinical Research Computing Unit (University of Pennsylvania)
Recruiting
Bronchoprotection of Salbutamol in Asthma and Chronic Obstructive Pulmonary Disease

Conditions: Asthma; COPD
Intervention: Drug: salbutamol
Sponsor: University of Saskatchewan
Recruiting
Blood, Urine, and Tissue Collection for Cutaneous Lymphoma, Eczema, and Atopic Dermatitis Research

Conditions: Cutaneous T-cell Lymphoma; Sezary Syndrome; Mycosis Fungoides; Eczema; Atopic Dermatitis
Intervention: Other: Blood draw or skin biopsy
Sponsor: University of Pittsburgh
Recruiting
Studies of the Natural History, Pathogenesis, and Outcome of Autoinflammatory Diseases (NOMID / CAPS, DIRA, CANDLE, SAVI, CRMO, Still's Disease, Behcet's Disease, and Other Undifferentiated Autoinflammatory Diseases)

Conditions: Urticaria; Arthropathy; Lymphadenopathy; Nervous System Anomalies
Intervention:
Sponsor: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Recruiting
Activation and Function of Eosinophils in Conditions With Blood or Tissue Eosinophilia

Conditions: Asthma; Eosinophilia; Helminthiasis; Hypersensitivity; Parasitic Disease
Intervention:
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting
Sample Collections From the Airways of Asthmatic Patients

Condition: Asthma
Intervention:
Sponsor: National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

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